PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2561443-0	1989	Superoxide--driven oxidation of quercetin and a simple sensitive assay for determination of superoxide dismutase.	Quercetin	32-41	superoxide dismutase 1	Homo sapiens	92-112
2561443-1	1989	Oxidation of quercetin at pH 10 was shown to be a free radical chain reaction involving superoxide and hence inhibitable by superoxide dismutase (SOD) (EC 1.15.1.1).	Quercetin	13-22	superoxide dismutase 1	Homo sapiens	124-144
2561443-1	1989	Oxidation of quercetin at pH 10 was shown to be a free radical chain reaction involving superoxide and hence inhibitable by superoxide dismutase (SOD) (EC 1.15.1.1).	Quercetin	13-22	superoxide dismutase 1	Homo sapiens	146-149
2706741-9	1989	Chlordane- and TPA- stimulated PKC activity was phospholipid-dependent and could be inhibited by quercetin, a known inhibitor of PKC activity.	Quercetin	97-106	protein kinase C, gamma	Rattus norvegicus	31-34
2518221-2	1989	Sulfonic derivatives of quercetin were much weaker inhibitors of soybean lipoxygenase than quercetin itself.	Quercetin	24-33	linoleate 9S-lipoxygenase-4	Glycine max	73-85
2502118-7	1989	The following compounds were evaluated as inhibitors of the 5-lipoxygenase reaction and caused a 50% decrease in product accumulation (IC50) at the indicated concentrations: quercetin, L-651,896, L-656,224, MTPPH and L-651,392 (0.3-0.5 microM); diphenyldisulfide (2-5 microM); phenidone (5-10 microM); AA861 (4-10 microM) and BW755C (4-15 microM).	Quercetin	174-183	arachidonate 5-lipoxygenase	Homo sapiens	60-74
2706741-9	1989	Chlordane- and TPA- stimulated PKC activity was phospholipid-dependent and could be inhibited by quercetin, a known inhibitor of PKC activity.	Quercetin	97-106	protein kinase C, gamma	Rattus norvegicus	129-132
2564319-12	1989	Quercetin, a pkC inhibitor which has been reported to eliminate DDT- or TPA-induced inhibition of intercellular communication, was investigated in an in vivo study that measured promotion of enzyme-altered foci in DEN-treated rat liver.	Quercetin	0-9	protein kinase C, gamma	Rattus norvegicus	13-16
2561443-2	1989	The degree of inhibition of quercetin oxidation was a function of SOD concentration, and fifty percent inhibition was produced by approximately 1.5 ng/ml of pure enzyme.	Quercetin	28-37	superoxide dismutase 1	Homo sapiens	66-69
3218613-6	1988	Increasing substrate concentration (9-144 nmols) relieved the inhibition of HSF-PLA2 activity by quercetin indicating probable interaction with the substrate.	Quercetin	97-106	interleukin 6	Homo sapiens	76-79
2786615-1	1989	Anti-inflammatory potentials of a safe, common dietary component, quercetin, were investigated in suppression of intraocular inflammation induced by retinal S antigen.	Quercetin	66-75	S-antigen visual arrestin	Rattus norvegicus	149-166
3218613-6	1988	Increasing substrate concentration (9-144 nmols) relieved the inhibition of HSF-PLA2 activity by quercetin indicating probable interaction with the substrate.	Quercetin	97-106	phospholipase A2 group IIA	Homo sapiens	80-84
3218613-8	1988	both retinal and quercetin quenched the relative fluorescent intensity of N. m. mossambica PLA2 and in a dose-dependent manner in the same concentration range at which they inhibit in vitro PLA2 activity.	Quercetin	17-26	phospholipase A2 group IIA	Homo sapiens	91-95
3218613-8	1988	both retinal and quercetin quenched the relative fluorescent intensity of N. m. mossambica PLA2 and in a dose-dependent manner in the same concentration range at which they inhibit in vitro PLA2 activity.	Quercetin	17-26	phospholipase A2 group IIA	Homo sapiens	190-194
3164998-2	1988	The phosphotransferase activity of an oncogene product, pp130fps, and a growth factor receptor, insulin receptor, were inhibited by myricetin, a derivative of quercetin.	Quercetin	159-168	insulin receptor	Homo sapiens	96-112
2972256-9	1988	Quercetin did, however, inhibit ATPase activity of plasma membrane, suggesting that this unidentified ATPase may contribute to the formation of ADP and Pi required for lactate production by the intact cell.	Quercetin	0-9	dynein, axonemal, heavy chain 8	Mus musculus	32-38
2972256-9	1988	Quercetin did, however, inhibit ATPase activity of plasma membrane, suggesting that this unidentified ATPase may contribute to the formation of ADP and Pi required for lactate production by the intact cell.	Quercetin	0-9	dynein, axonemal, heavy chain 8	Mus musculus	102-108
3191199-2	1988	Quercetin and rutin were found to inhibit NADPH and CCl4-dependent LPO in rat liver microsomes, however, in the case of CCl4-dependent LPO, rutin had a very poor antioxidant effect.	Quercetin	0-9	C-C motif chemokine ligand 4	Rattus norvegicus	52-56
2836234-0	1988	Human myeloperoxidase activity is inhibited in vitro by quercetin.	Quercetin	56-65	myeloperoxidase	Homo sapiens	6-21
3133109-6	1988	Inhibitors of PKC, such as chlorpromazine, quercetin, and staurosporine inhibited these increases in phosphorylations of p34 and p40 on TPA treatment.	Quercetin	43-52	alpha- and gamma-adaptin binding protein	Mus musculus	121-124
3133109-6	1988	Inhibitors of PKC, such as chlorpromazine, quercetin, and staurosporine inhibited these increases in phosphorylations of p34 and p40 on TPA treatment.	Quercetin	43-52	interleukin 12b	Mus musculus	129-132
2836234-2	1988	Quercetin is an effective inhibitor of human myeloperoxidase (MPO) activity, both with purified enzyme (IC50 = 3.5 microM) and in a system using stimulated human neutrophils.	Quercetin	0-9	myeloperoxidase	Homo sapiens	45-60
2836234-2	1988	Quercetin is an effective inhibitor of human myeloperoxidase (MPO) activity, both with purified enzyme (IC50 = 3.5 microM) and in a system using stimulated human neutrophils.	Quercetin	0-9	myeloperoxidase	Homo sapiens	62-65
2836234-3	1988	Quercetin is significantly more potent than three other related compounds (rutin, rutin sulfate and troxerutin) and than methimazole, a previously-known myeloperoxidase inhibitor.	Quercetin	0-9	myeloperoxidase	Homo sapiens	153-168
2836234-5	1988	Moreover, quercetin is directly able to scavenge hypochlorous acid (HOCl), a chlorinated species generated by the MPO/H2O2/Cl- system.	Quercetin	10-19	myeloperoxidase	Homo sapiens	114-117
3128297-9	1988	Quercetin was the most potent and it inhibited the lipoxygenase in the liposomal suspension by about 42% while the other flavonoids inhibited the enzyme by about 14-23%.	Quercetin	0-9	linoleate 9S-lipoxygenase-4	Glycine max	51-63
2968941-1	1988	Flavonoids (quercetin, rutin) influence ATPase activity and actomyosin superprecipitation.	Quercetin	12-21	dynein axonemal heavy chain 8	Homo sapiens	40-46
2822142-8	1987	(4) Inhibition of protein kinase C activity by drugs reported to inhibit the enzyme (retinoic acid, quercetin) abolishes the stimulation of brain isozyme of creatine kinase activity and of DNA synthesis by PTH.	Quercetin	100-109	parathyroid hormone	Homo sapiens	206-209
2962642-6	1987	For both Ca2+-ATPase proteins, quercetin has an affinity for the E-Ca2 (fully ligated with respect to calcium at the exterior high-affinity calcium binding sites, unligated with respect to ATP) conformational state of the protein that is approximately 10-fold greater than for other conformational states in the hydrolytic cycle.	Quercetin	31-40	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	65-70
3497895-6	1987	These peroxyl radicals cannot be observed directly, but their reactions with the two flavonols, kaempferol and quercetin, acting as radical-scavenging antioxidants, produced strongly absorbing aroxyl radicals (ArO.).	Quercetin	111-120	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	210-213
3499481-1	1987	Quercetin was able to reduce the cytotoxic effect of T-2 mycotoxin on cultured murine thymocytes.	Quercetin	0-9	brachyury 2	Mus musculus	53-56
3036157-3	1987	Contrary to W-7, nicergoline, nicardipine and quercetin, which decreased the fluorescence of the two probes bound to calmodulin, bepridil only decreased 9AC fluorescence but increased the fluorescence intensity at the wavelength of the emission maximum of TNS.	Quercetin	46-55	calmodulin 1	Homo sapiens	117-127
3499481-2	1987	When given to mice immediately before challenge with T-2 mycotoxins, quercetin significantly reduced mortality.	Quercetin	69-78	brachyury 2	Mus musculus	53-56
3106804-2	1987	The inducing activity of quercetin is higher for sfiA than for recA and umuC genes in the absence of S9 mix.	Quercetin	25-34	RAD51 recombinase	Homo sapiens	63-67
3297842-3	1987	Agents that inhibit protein kinase C (polymyxin B, gossypol and quercitin) also inhibited glucose transport that had been stimulated by DOG, TPA, PLC and insulin.	Quercetin	64-73	insulin	Canis lupus familiaris	154-161
3621371-4	1987	Cytosolic epoxide hydrolase activity was induced by chlorinated paraffins, di(2-ethylhexyl)phthalate and clofibrate and depressed by alpha-naphthylisothiocyanate, 3-methylcholanthrene, benzil and quercitin.	Quercetin	196-205	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-27
3106804-1	1987	The induction of recA, umuC and sfiA genes by quercetin was studied in the presence and in the absence of S9 mix.	Quercetin	46-55	RAD51 recombinase	Homo sapiens	17-21
3492267-10	1987	Further in vivo studies showed that a single topical application of tannic acid, quercetin, and myricetin greatly diminished epidermal AHH (53-65%), ethoxycoumarin O-deethylase (30-68%), and ethoxyresorufin O-deethylase (66-97%) activities whereas anthraflavic acid was ineffective in this regard even when repeatedly applied.	Quercetin	81-90	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	135-138
3303039-5	1987	Mouse lung CBR exhibited optimal activity at pH 5.0; a preference for NADPH as coenzyme, although reactive with NADH at an order of magnitude higher concentration; poor activity as an ADH, but was strongly inhibited by 4-methyl pyrazole; and was inhibited by quercitin, dithiothreitol and p-OH-mercuribenzoate, but was insensitive to valproate or sorbinil.	Quercetin	259-268	carbonyl reductase 1	Mus musculus	11-14
3097147-14	1987	Inhibitors of PKC known to have minimal effects on RNA synthesis, quercetin and gossypol, totally inhibited both the elevations of ODC activity and [3H]thymidine incorporation in response to PRL in Nb 2 lymphoma cells.	Quercetin	66-75	prolactin	Rattus norvegicus	191-194
3736343-2	1986	In mucolipidosis II fibroblast cultures, characterized by their preferential secretion of most newly synthesized hydrolases, quercetin and phloretin (200 microM) inhibited beta-hexosaminidase synthesis as well as total culture-associated enzyme activity.	Quercetin	125-134	O-GlcNAcase	Homo sapiens	172-191
3814119-1	1986	Glutathione S-transferase (GST) isoenzymes isolated from human tissues and rat liver are differentially inhibited by quercetin, alizarin, purpurogallin and ellagic acid.	Quercetin	117-126	glutathione S-transferase kappa 1	Homo sapiens	0-25
3814119-1	1986	Glutathione S-transferase (GST) isoenzymes isolated from human tissues and rat liver are differentially inhibited by quercetin, alizarin, purpurogallin and ellagic acid.	Quercetin	117-126	glutathione S-transferase kappa 1	Homo sapiens	27-30
3331657-4	1986	The genotoxicity of quercetin, rutin and commercial red wine has been studied for the induction of: (i) reverse mutation in the Ames assay; (ii) SOS functions in the SOS Chromotest; (iii) sister-chromatid exchanges (SCEs) in human lymphocytes.	Quercetin	20-29	xylosyltransferase 2	Homo sapiens	145-148
3527705-7	1986	Although many properties of YCK-2 and LCK-2, including substrate specificity, inhibition by heparin, polyglutamic acid and quercetin and stimulation by polyamines, are similar; their stability under denaturing and dissociating conditions and their response to polybasic peptides are quite different.	Quercetin	123-132	serine/threonine protein kinase YCK2	Saccharomyces cerevisiae S288C	28-33
3331657-4	1986	The genotoxicity of quercetin, rutin and commercial red wine has been studied for the induction of: (i) reverse mutation in the Ames assay; (ii) SOS functions in the SOS Chromotest; (iii) sister-chromatid exchanges (SCEs) in human lymphocytes.	Quercetin	20-29	xylosyltransferase 2	Homo sapiens	166-169
3331657-5	1986	While in the Ames assay the mutagenicity of quercetin is enhanced by the presence of rat liver microsomal enzymes (S9) or the respective cytosolic fraction (S100), genotoxicity is reduced when the induction of SOS responses is assessed using the SOS Chromotest.	Quercetin	44-53	xylosyltransferase 2	Homo sapiens	210-213
3331657-5	1986	While in the Ames assay the mutagenicity of quercetin is enhanced by the presence of rat liver microsomal enzymes (S9) or the respective cytosolic fraction (S100), genotoxicity is reduced when the induction of SOS responses is assessed using the SOS Chromotest.	Quercetin	44-53	xylosyltransferase 2	Homo sapiens	246-249
3455757-7	1986	Addition of quercetin (0.1 mM) and trans-flupenthixol (0.2 mM), inhibitors of nuclear protein kinase II and calmodulin-dependent kinase, respectively, inhibited the synthesis of vitellogenin mRNA by about 55% without affecting total RNA synthesis.	Quercetin	12-21	calmodulin 2	Gallus gallus	108-118
11538660-5	1986	The nuclear NTPase activity was not inhibited by vanadate, oligomycin, or nitrate, but was inhibited by relatively low concentrations of quercetin and the calmodulin inhibitor, compound 48/80.	Quercetin	137-146	inosine triphosphatase	Homo sapiens	12-18
11538660-5	1986	The nuclear NTPase activity was not inhibited by vanadate, oligomycin, or nitrate, but was inhibited by relatively low concentrations of quercetin and the calmodulin inhibitor, compound 48/80.	Quercetin	137-146	calmodulin 1	Homo sapiens	155-165
3455757-7	1986	Addition of quercetin (0.1 mM) and trans-flupenthixol (0.2 mM), inhibitors of nuclear protein kinase II and calmodulin-dependent kinase, respectively, inhibited the synthesis of vitellogenin mRNA by about 55% without affecting total RNA synthesis.	Quercetin	12-21	vitellogenin 2	Gallus gallus	178-190
2410511-6	1985	IgE-mediated histamine release from monkey intestinal mast cells differed from that observed from rat intestinal mast cells in that release was inhibited not only by quercetin but also by theophylline.	Quercetin	166-175	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
2935488-6	1985	Cellular ATPases, inhibited by quercetin, but not the ouabain-sensitive Na+, K+-ATPase, appeared to participate, whereas the amiloride-sensitive plasma membrane Na+/H+ exchanger and the intracellular levels of cGMP did not seem to influence the system.	Quercetin	31-40	dynein axonemal heavy chain 8	Homo sapiens	9-15
3972457-0	1985	Inhibition of neutrophil phospholipase A2 by p-bromophenylacyl bromide, nordihydroguaiaretic acid, 5,8,11,14-eicosatetraynoic acid and quercetin.	Quercetin	135-144	phospholipase A2 group IB	Homo sapiens	25-41
3864171-0	1985	Inhibitory action of quercetin on xanthine oxidase and xanthine dehydrogenase activity.	Quercetin	21-30	xanthine dehydrogenase	Rattus norvegicus	55-77
3864171-1	1985	Quercetin is an equally good inhibitor of xanthine oxidase (type O, oxygen-reducing enzyme) and xanthine dehydrogenase (type D, NAD+-reducing enzyme) activity of a preparation of the xanthine-oxidizing enzyme partially purified from rat liver.	Quercetin	0-9	xanthine dehydrogenase	Rattus norvegicus	42-118
3839399-7	1985	Three of the four aglycones (quercetin, kaempferol, isoscutellarein, in descending order of potency) were inhibitory to PGDH with ID50 values in the range 130-2100 microM.	Quercetin	29-38	15-hydroxyprostaglandin dehydrogenase	Rattus norvegicus	120-124
2986975-12	1985	Quercetin, a bioflavonoid, acts as a strong inhibitor of p68 protein kinase activity.	Quercetin	0-9	GATA zinc finger domain containing 2B	Homo sapiens	57-60
3925883-0	1985	Inhibition of cytochrome P-450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin.	Quercetin	102-111	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	14-30
3925883-1	1985	The kinetic characteristics and mechanism of flavonoid inhibition of cytochrome P-450-mediated reactions were examined in rat liver microsomes, using the naturally occurring flavonoid, quercetin (3,3",4",5,7-pentahydroxyflavone).	Quercetin	185-194	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	69-85
3925883-1	1985	The kinetic characteristics and mechanism of flavonoid inhibition of cytochrome P-450-mediated reactions were examined in rat liver microsomes, using the naturally occurring flavonoid, quercetin (3,3",4",5,7-pentahydroxyflavone).	Quercetin	196-227	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	69-85
2998008-6	1985	Quercetin, an inhibitor of some protein kinases, inhibited the kinase phosphorylating p50 but not the kinase phosphorylating p37mos and p43.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	86-89
6092041-3	1984	This protein kinase activity is inhibited by the bioflavonoid quercetin at doses that do not inhibit cAMP-dependent protein kinase activity.	Quercetin	62-71	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	5-19
11540853-7	1985	Other flavonoids such as epicatechin, quercetin and naringenin also inhibited calmodulin-promoted phosphodiesterase activity.	Quercetin	38-47	calmodulin1	Zea mays	78-88
6092041-5	1984	By following the physiological cycle of mammary gland development during pregnancy, lactation, and weaning, we found a close correlation between proliferation, expressed as the DNA content per gland, and quercetin-inhibited cytosolic protein kinase activity.	Quercetin	204-213	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	234-248
6092041-12	1984	These results suggest that quercetin-inhibitable protein kinase activity is not merely another estrogenic marker, but represents more general regulatory activity which might be connected to growth processes of breast tissue.	Quercetin	27-36	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	49-63
6327791-4	1984	In contrast, the release of lysosomal beta-glucuronidase from neutrophils stimulated with opsonized zymosan was only inhibited by two flavonoids, quercetin and chalcone, and only at concentrations of 1.5 X 10(-4)M to 2 X 10(-4)M. Quercetin also inhibited the generation of superoxide anion by neutrophils but to a lesser degree than its effect on CL.	Quercetin	146-155	glucuronidase beta	Homo sapiens	38-56
6327791-4	1984	In contrast, the release of lysosomal beta-glucuronidase from neutrophils stimulated with opsonized zymosan was only inhibited by two flavonoids, quercetin and chalcone, and only at concentrations of 1.5 X 10(-4)M to 2 X 10(-4)M. Quercetin also inhibited the generation of superoxide anion by neutrophils but to a lesser degree than its effect on CL.	Quercetin	230-239	glucuronidase beta	Homo sapiens	38-56
6698173-0	1984	Quercetin interacts with calmodulin, a calcium regulatory protein.	Quercetin	0-9	calmodulin 1	Homo sapiens	25-35
6735033-0	1984	Interaction between quercetin and Ca2+-calmodulin complex: possible mechanism for anti-tumor-promoting action of the flavonoid.	Quercetin	20-29	calmodulin 1	Homo sapiens	39-49
6735033-1	1984	Quercetin was found to have similar inhibitory effects on tumor promoter-induced phenomena to those of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist.	Quercetin	0-9	calmodulin 1	Homo sapiens	157-167
6735033-2	1984	Moreover, quercetin was shown to interact directly with the Ca2+-calmodulin complex.	Quercetin	10-19	calmodulin 1	Homo sapiens	65-75
6735033-3	1984	These results suggest that quercetin may act as a calmodulin antagonist, and that its antagonistic effect on calmodulin may be important in its anti-tumor-promoting action in vivo.	Quercetin	27-36	calmodulin 1	Homo sapiens	50-60
6717476-1	1984	The naturally occurring flavonol, quercetin, was investigated concerning its ability to induce SCEs and HGPRT-deficient mutants in V79 Chinese hamster cells, and HGPRT- and TK-deficient mutants in mouse lymphoma L5178Y cells.	Quercetin	34-43	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	104-109
6717476-1	1984	The naturally occurring flavonol, quercetin, was investigated concerning its ability to induce SCEs and HGPRT-deficient mutants in V79 Chinese hamster cells, and HGPRT- and TK-deficient mutants in mouse lymphoma L5178Y cells.	Quercetin	34-43	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	162-167
6698173-1	1984	Quercetin was found to interact with the Ca2+-calmodulin complex, suggesting that it may act as a calmodulin antagonist in vivo to inhibit calmodulin-dependent phenomena caused by biologically active agents, including tumor promoters.	Quercetin	0-9	calmodulin 1	Homo sapiens	46-56
6698173-1	1984	Quercetin was found to interact with the Ca2+-calmodulin complex, suggesting that it may act as a calmodulin antagonist in vivo to inhibit calmodulin-dependent phenomena caused by biologically active agents, including tumor promoters.	Quercetin	0-9	calmodulin 1	Homo sapiens	98-108
6698173-1	1984	Quercetin was found to interact with the Ca2+-calmodulin complex, suggesting that it may act as a calmodulin antagonist in vivo to inhibit calmodulin-dependent phenomena caused by biologically active agents, including tumor promoters.	Quercetin	0-9	calmodulin 1	Homo sapiens	98-108
6409111-2	1983	Quercetin, the major pentahydroxyflavone, was observed to inhibit human lens aldose reductase by 50% at a concentration of 5 X 10(-6) M. The inhibitory activity of its 3-O-glucoside was similar to that of the parent aglycon.	Quercetin	0-9	aldo-keto reductase family 1 member B	Homo sapiens	77-93
6704949-4	1984	Quercetin is also a potent inhibitor of calcium, phospholipid-dependent protein kinase (Ca, PL-PK).	Quercetin	0-9	interleukin-1 receptor-associated kinase 1	Mus musculus	92-97
6135447-6	1983	The Ca+ uptake was inhibited by low concentrations of quercetin, which is known to be an inhibitor of (Ca2+ + Mg2+)-ATPase in many systems.	Quercetin	54-63	carbonic anhydrase 2	Homo sapiens	103-106
6437167-1	1984	Oxygen, oxidizing enzymes such as polyphenol oxidase (tyrosinase) and alkaline pH, irreversibly inactivate the mutagenicity of quercetin in the Ames test.	Quercetin	127-136	tyrosinase	Homo sapiens	54-64
6661236-1	1983	The flavonoid quercetin is a potent inhibitor of calcium- and phospholipid-dependent protein kinase (Ca, PL-PK) activity from mouse brain.	Quercetin	14-23	interleukin-1 receptor-associated kinase 1	Mus musculus	105-110
6311542-1	1983	The phosphotransferase activity of the Rous sarcoma virus src gene product, pp60src, was inhibited both in vitro and in vivo by the bioflavonoid quercetin.	Quercetin	145-154	p60 src	Rous sarcoma virus	58-61
6413085-0	1983	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition.	Quercetin	115-124	ornithine decarboxylase, structural 1	Mus musculus	79-102
6413085-2	1983	TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10-30 mumol/mouse), but it failed to inhibit the stimulation of epidermal DNA synthesis by TPA.	Quercetin	99-108	ornithine decarboxylase, structural 1	Mus musculus	38-61
6413085-2	1983	TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10-30 mumol/mouse), but it failed to inhibit the stimulation of epidermal DNA synthesis by TPA.	Quercetin	99-108	ornithine decarboxylase, structural 1	Mus musculus	63-66
6413085-5	1983	These results suggest that the inhibition of lipoxygenase by quercetin is one of the major actions of the above agent to inhibit tumor promotion and TPA-induced ODC activity.	Quercetin	61-70	ornithine decarboxylase, structural 1	Mus musculus	161-164
6818414-1	1982	Quercetin inhibited in a concentration-dependent manner the release of beta-glucuronidase from human polymorphonuclear leukocytes stimulated with zymosan-activated serum.	Quercetin	0-9	glucuronidase beta	Homo sapiens	71-89
6221726-1	1983	F1-ATPase obtained from mesophilic organisms is inhibited by specific inhibitors, such as aurovertin, efrapeptin, quercetin and several local anesthetics.	Quercetin	114-123	dynein axonemal heavy chain 8	Homo sapiens	3-9
6297578-9	1983	Both Ca2+ transport and Ca2+-ATPase activity were inhibited by the flavonoid quercetin.	Quercetin	77-86	dynein axonemal heavy chain 8	Homo sapiens	29-35
6297578-10	1983	Thus, ram spermatozoa plasma membranes have both a Ca2+ transport activity and a Ca2+-stimulated ATPase activity with similar substrate affinities and specificities and similar sensitivity to quercetin.	Quercetin	192-201	dynein axonemal heavy chain 8	Homo sapiens	97-103
6818414-4	1982	These observations suggest that the zymosan-activated serum stimulus activates phospholipase A2 and that phospholipase A2 is inhibited by quercetin.	Quercetin	138-147	phospholipase A2 group IB	Homo sapiens	105-121
6182778-1	1982	Quercetin and 12 other natural flavonoid aglycones inhibit washed human platelet aggregation and secretion of serotonin induced by ADP, collagen or thrombin.	Quercetin	0-9	coagulation factor II, thrombin	Homo sapiens	148-156
6814912-5	1982	Flavonoids, e.g. quercetin and rutin, inhibit aldose reductase (IC50 = 2 - 5 microM).	Quercetin	17-26	aldo-keto reductase family 1 member B	Homo sapiens	46-62
6284174-0	1982	Selective inhibition of a cyclic nucleotide independent protein kinase (G type casein kinase) by quercetin and related polyphenols.	Quercetin	97-106	PDLIM1 interacting kinase 1 like	Homo sapiens	79-92
7306144-0	1981	Photo-induced covalent labelling of malate dehydrogenase by quercetin.	Quercetin	60-69	malic enzyme 1	Homo sapiens	36-56
6800960-4	1982	Arachidonic acid antagonists, nordihydroguaiaretic acid and quercetin caused dose-dependent inhibition of release induced by C3a plus cytochalasin B, however, lysozyme release induced by C3a in the absence of cytochalasin B was minimally affected.	Quercetin	60-69	complement C3	Homo sapiens	125-128
6800960-4	1982	Arachidonic acid antagonists, nordihydroguaiaretic acid and quercetin caused dose-dependent inhibition of release induced by C3a plus cytochalasin B, however, lysozyme release induced by C3a in the absence of cytochalasin B was minimally affected.	Quercetin	60-69	complement C3	Homo sapiens	187-190
6452897-7	1981	Adenylyl imidodiphosphate and quercetin, two compounds which partially mimic the inhibitory effect of IF1 on ATPase activity of F1, markedly prevented the binding of (14C)MABI-IF1 to F1; on the other hand, aurovertin, a specific ligand of the beta subunit of F1, did not affect the interaction between (14C)MABI-IF1 and F1.	Quercetin	30-39	ATP synthase inhibitory factor subunit 1	Homo sapiens	102-105
6268437-1	1981	A highly significant enhancement of the hydrosmotic actions both of vasopressin and of exogenous cAMP was seen in the presence of quercetin.	Quercetin	130-139	arginine vasopressin	Homo sapiens	68-79
6452897-7	1981	Adenylyl imidodiphosphate and quercetin, two compounds which partially mimic the inhibitory effect of IF1 on ATPase activity of F1, markedly prevented the binding of (14C)MABI-IF1 to F1; on the other hand, aurovertin, a specific ligand of the beta subunit of F1, did not affect the interaction between (14C)MABI-IF1 and F1.	Quercetin	30-39	ATP synthase inhibitory factor subunit 1	Homo sapiens	176-179
6452897-7	1981	Adenylyl imidodiphosphate and quercetin, two compounds which partially mimic the inhibitory effect of IF1 on ATPase activity of F1, markedly prevented the binding of (14C)MABI-IF1 to F1; on the other hand, aurovertin, a specific ligand of the beta subunit of F1, did not affect the interaction between (14C)MABI-IF1 and F1.	Quercetin	30-39	ATP synthase inhibitory factor subunit 1	Homo sapiens	176-179
418268-1	1978	The possible effects of Quercetine, a potent inhibitor of aldose-reductase, on cataract formation and vascular permeability were investigated in streptozotocine-diabetic rats.	Quercetin	24-34	aldo-keto reductase family 1 member B1	Rattus norvegicus	58-74
7448777-4	1981	Quercetin, morin, and kaempferol inhibited cytochrome c (P-450) reductase in human liver microsomes whereas flavone and 7,8-benzoflavone had no effect.	Quercetin	0-9	cytochrome c, somatic	Homo sapiens	43-55
7448777-5	1981	These results suggest that the inhibitory effects of quercetin, morin, and kaempferol on monooxygenase activity may be caused at least in part by an inhibition in the reduction of cytochrome P-450.	Quercetin	53-62	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	180-196
33070227-14	2021	We conclude that quercetin inhibited the growth, migration, and invasion and induced apoptosis of PCCs by antagonizing SHH and TGF-beta/Smad signaling pathways.	Quercetin	17-26	sonic hedgehog	Mus musculus	119-122
19400030-0	1974	Effects of quercetin and F1 inhibitor on mitochondrial ATPase and energy-linked reactions in submitochondrial particles.	Quercetin	11-20	ATP synthase F1 subunit epsilon	Homo sapiens	41-61
19400030-1	1974	Quercetin (3,3",4",5,7-pentahydroxyflavone) shares certain properties with the mitochondrial ATPase inhibitor protein.	Quercetin	0-9	ATP synthase F1 subunit epsilon	Homo sapiens	79-99
33892270-4	2021	Moreover, they revealed potent inhibitory activities against 15-LOX enzyme compared to reference quercetin (IC50 = 1.81-3.60 vs. 3.34 muM).	Quercetin	97-106	arachidonate 15-lipoxygenase	Mus musculus	61-67
33581257-10	2021	Through molecular docking, it was found that the four hub targets (TP53, IL6, VEGFA, and AKT1) binds luteolin and quercetin more tightly.	Quercetin	114-123	tumor protein p53	Rattus norvegicus	67-71
33581257-10	2021	Through molecular docking, it was found that the four hub targets (TP53, IL6, VEGFA, and AKT1) binds luteolin and quercetin more tightly.	Quercetin	114-123	interleukin 6	Rattus norvegicus	73-76
33581257-10	2021	Through molecular docking, it was found that the four hub targets (TP53, IL6, VEGFA, and AKT1) binds luteolin and quercetin more tightly.	Quercetin	114-123	vascular endothelial growth factor A	Rattus norvegicus	78-83
33581257-10	2021	Through molecular docking, it was found that the four hub targets (TP53, IL6, VEGFA, and AKT1) binds luteolin and quercetin more tightly.	Quercetin	114-123	AKT serine/threonine kinase 1	Rattus norvegicus	89-93
14194606-0	1964	QUERCETIN INHIBITION OF SPECIFIC HISTIDINE DECARBOXYLASE.	Quercetin	0-9	histidine decarboxylase	Homo sapiens	33-56
33070227-0	2021	Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-beta/Smad signaling pathways.	Quercetin	0-9	sonic hedgehog	Mus musculus	84-87
33070227-0	2021	Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-beta/Smad signaling pathways.	Quercetin	0-9	transforming growth factor alpha	Mus musculus	92-100
33070227-3	2021	Here, we report that the dietary bioflavonoid quercetin has therapeutic potential for PDA by targeting sonic hedgehog (SHH) signaling.	Quercetin	46-55	sonic hedgehog	Mus musculus	103-117
33070227-3	2021	Here, we report that the dietary bioflavonoid quercetin has therapeutic potential for PDA by targeting sonic hedgehog (SHH) signaling.	Quercetin	46-55	sonic hedgehog	Mus musculus	119-122
33070227-14	2021	We conclude that quercetin inhibited the growth, migration, and invasion and induced apoptosis of PCCs by antagonizing SHH and TGF-beta/Smad signaling pathways.	Quercetin	17-26	transforming growth factor alpha	Mus musculus	127-135
33070227-7	2021	In addition, quercetin suppressed epithelial-mesenchymal transition (EMT) by reducing TGF-beta1 level, which resulted in inhibition of PCC migration and invasion.	Quercetin	13-22	transforming growth factor, beta 1	Mus musculus	86-95
33070227-10	2021	Mechanically, quercetin exerts its therapeutic effects on PDA by decreasing SHH activity.	Quercetin	14-23	sonic hedgehog	Mus musculus	76-79
33070227-11	2021	Interestingly, quercetin-induced SHH inactivation is mainly dependent on Gli2, but not Gli1.	Quercetin	15-24	sonic hedgehog	Mus musculus	33-36
33070227-11	2021	Interestingly, quercetin-induced SHH inactivation is mainly dependent on Gli2, but not Gli1.	Quercetin	15-24	GLI-Kruppel family member GLI2	Mus musculus	73-77
33070227-12	2021	Enhance SHH activity by recombinant Shh protein abolished the quercetin-mediated inhibition of PCC proliferation, migration, and invasion.	Quercetin	62-71	sonic hedgehog	Mus musculus	8-11
33070227-12	2021	Enhance SHH activity by recombinant Shh protein abolished the quercetin-mediated inhibition of PCC proliferation, migration, and invasion.	Quercetin	62-71	sonic hedgehog	Mus musculus	36-39
33831503-0	2021	The flavonoid quercetin reduces cell migration and increases NIS and E-cadherin mRNA in the human thyroid cancer cell line BCPAP.	Quercetin	14-23	solute carrier family 5 member 5	Homo sapiens	61-64
33070227-13	2021	Furthermore, Shh activated TGF-beta1/Smad2/3 signaling and promoted EMT by inducing the expression of Zeb2 and Snail1 that eventually resulted in a partial reversal of quercetin-mediated inhibition of PCC migration and invasion.	Quercetin	168-177	sonic hedgehog	Mus musculus	13-16
33070227-13	2021	Furthermore, Shh activated TGF-beta1/Smad2/3 signaling and promoted EMT by inducing the expression of Zeb2 and Snail1 that eventually resulted in a partial reversal of quercetin-mediated inhibition of PCC migration and invasion.	Quercetin	168-177	zinc finger E-box binding homeobox 2	Mus musculus	102-106
33070227-13	2021	Furthermore, Shh activated TGF-beta1/Smad2/3 signaling and promoted EMT by inducing the expression of Zeb2 and Snail1 that eventually resulted in a partial reversal of quercetin-mediated inhibition of PCC migration and invasion.	Quercetin	168-177	snail family zinc finger 1	Mus musculus	111-117
33016666-3	2021	Molecular docking studies have highlighted that quercetin, a natural polyphenol belonging to the flavonol class, inhibits 3CLpro, PLpro and S proteins.	Quercetin	48-57	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	130-135
33016666-9	2021	Taking also into considerations its anti-inflammatory and thrombin-inhibitory actions, a bioavailable form of quercetin, like Quercetin Phytosome , should be considered a possible candidate to clinically face COVID-19.	Quercetin	110-119	coagulation factor II, thrombin	Homo sapiens	58-66
32787531-5	2021	From the experiment, Epigallocatechin gallate was found to be the best ligand to inhibit CDK-2, Daidzein showed the best inhibitory activities towards the Human topoisomerase IIalpha, and Quercetin was predicted to be the best agent against VEGFR-2.	Quercetin	188-197	cyclin dependent kinase 2	Homo sapiens	89-94
32787531-5	2021	From the experiment, Epigallocatechin gallate was found to be the best ligand to inhibit CDK-2, Daidzein showed the best inhibitory activities towards the Human topoisomerase IIalpha, and Quercetin was predicted to be the best agent against VEGFR-2.	Quercetin	188-197	kinase insert domain receptor	Homo sapiens	241-248
33831503-0	2021	The flavonoid quercetin reduces cell migration and increases NIS and E-cadherin mRNA in the human thyroid cancer cell line BCPAP.	Quercetin	14-23	cadherin 1	Homo sapiens	69-79
33831503-9	2021	Additionally, quercetin increased NIS expression and function.	Quercetin	14-23	solute carrier family 5 member 5	Homo sapiens	34-37
33993958-11	2021	Quercetin normalized the increased levels of acetylcholinesterase and ammonia.	Quercetin	0-9	acetylcholinesterase	Rattus norvegicus	45-65
33993958-13	2021	Also, quercetin increased superoxide dismutase, catalase and glutathione peroxidase activities, and reduced nitrite and peroxynitrite levels in brains of rats.	Quercetin	6-15	catalase	Rattus norvegicus	48-56
33993958-14	2021	These findings further provide evidence of the ameliorative potential of quercetin against endosulfan-induced neurotoxicity via attenuation of neurochemical, ATPase changes, and inhibition of acetylcholinesterase activity, ammonia release and oxidative/nitrosative stress in rat brains.	Quercetin	73-82	acetylcholinesterase	Rattus norvegicus	192-212
34040433-0	2021	Quercetin Alleviates Neuropathic Pain in the Rat CCI Model by Mediating AMPK/MAPK Pathway.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	72-76
34058750-7	2021	The analysis indicated that quercetin could inhibit cytokines release, alleviate excessive immune responses and eliminate inflammation, through NF-kappaB, IL-17 and Toll-like receptor signaling pathway.	Quercetin	28-37	nuclear factor kappa B subunit 1	Homo sapiens	144-153
34058750-7	2021	The analysis indicated that quercetin could inhibit cytokines release, alleviate excessive immune responses and eliminate inflammation, through NF-kappaB, IL-17 and Toll-like receptor signaling pathway.	Quercetin	28-37	interleukin 17A	Homo sapiens	155-160
34052411-6	2021	Quercetin and salbutamol pretreatment considerably restored the expressions of Nrf-2, HO-1, and surfactant proteins to normal by attenuating the increase in oxidative stress, inflammation, and extravasations of plasma proteins in the animals under hypoxia.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-84
34052411-6	2021	Quercetin and salbutamol pretreatment considerably restored the expressions of Nrf-2, HO-1, and surfactant proteins to normal by attenuating the increase in oxidative stress, inflammation, and extravasations of plasma proteins in the animals under hypoxia.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	86-90
34051305-0	2021	The synergistic protection of EGCG and quercetin against streptozotocin (STZ)-induced NIT-1 pancreatic beta cell damage via upregulation of BCL-2 expression by miR-16-5p.	Quercetin	39-48	B cell leukemia/lymphoma 2	Mus musculus	140-145
34051305-4	2021	At the molecular level, the EGCG-quercetin combination upregulated BCL-2 expression and caused a greater reduction in miR-16-5p level than EGCG alone or quercetin alone.	Quercetin	33-42	B cell leukemia/lymphoma 2	Mus musculus	67-72
34051305-6	2021	These findings suggest that EGCG and quercetin exert synergistic anti-diabetes effect, possibly via decreasing the expression of miR-16-5p that targets directly BCL-2.	Quercetin	37-46	B cell leukemia/lymphoma 2	Mus musculus	161-166
34023442-0	2021	Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis.	Quercetin	0-9	sirtuin 1	Mus musculus	19-24
34023442-14	2021	RESULTS: Que treatment decreased the clinical score and left ankle thickness of CIA mice, attenuated the synovial inflammation and hyperplasia and bone/cartilage destruction in ankle joints, and decreased the secretion of IL-6, TNF-alpha, IL-1beta, IL-8, IL-13, and IL-17.	Quercetin	9-12	interleukin 6	Mus musculus	222-226
34023442-14	2021	RESULTS: Que treatment decreased the clinical score and left ankle thickness of CIA mice, attenuated the synovial inflammation and hyperplasia and bone/cartilage destruction in ankle joints, and decreased the secretion of IL-6, TNF-alpha, IL-1beta, IL-8, IL-13, and IL-17.	Quercetin	9-12	tumor necrosis factor	Mus musculus	228-237
34023442-14	2021	RESULTS: Que treatment decreased the clinical score and left ankle thickness of CIA mice, attenuated the synovial inflammation and hyperplasia and bone/cartilage destruction in ankle joints, and decreased the secretion of IL-6, TNF-alpha, IL-1beta, IL-8, IL-13, and IL-17.	Quercetin	9-12	interleukin 1 alpha	Mus musculus	239-247
34023442-14	2021	RESULTS: Que treatment decreased the clinical score and left ankle thickness of CIA mice, attenuated the synovial inflammation and hyperplasia and bone/cartilage destruction in ankle joints, and decreased the secretion of IL-6, TNF-alpha, IL-1beta, IL-8, IL-13, and IL-17.	Quercetin	9-12	chemokine (C-X-C motif) ligand 15	Mus musculus	249-253
34023442-14	2021	RESULTS: Que treatment decreased the clinical score and left ankle thickness of CIA mice, attenuated the synovial inflammation and hyperplasia and bone/cartilage destruction in ankle joints, and decreased the secretion of IL-6, TNF-alpha, IL-1beta, IL-8, IL-13, and IL-17.	Quercetin	9-12	interleukin 13	Mus musculus	255-260
34023442-14	2021	RESULTS: Que treatment decreased the clinical score and left ankle thickness of CIA mice, attenuated the synovial inflammation and hyperplasia and bone/cartilage destruction in ankle joints, and decreased the secretion of IL-6, TNF-alpha, IL-1beta, IL-8, IL-13, and IL-17.	Quercetin	9-12	interleukin 17A	Mus musculus	266-271
34019932-5	2021	The aim was to examine the effect of Corinthian currant polar phenolic extract and specific polar phenols resveratrol, quercetin, kaempferol and epigallocatechin gallate on AD-related functions of apoE4 forms.	Quercetin	119-128	apolipoprotein E	Homo sapiens	197-202
34019932-7	2021	Furthermore, resveratrol, quercetin, kaempferol and epigallocatechin gallate prevented redox status changes induced by Abeta42 uptake in SK-N-SH cells treated with lipid-free apoE4[L28P] or apoE4-165.	Quercetin	26-35	apolipoprotein E	Homo sapiens	175-180
34019932-7	2021	Furthermore, resveratrol, quercetin, kaempferol and epigallocatechin gallate prevented redox status changes induced by Abeta42 uptake in SK-N-SH cells treated with lipid-free apoE4[L28P] or apoE4-165.	Quercetin	26-35	apolipoprotein E	Homo sapiens	190-195
34040433-14	2021	Quercetin alleviates neuralgia in CCI rats by activating AMPK pathway and inhibiting MAPK pathway and its downstream targets, p-38, p-ERK, and p-JNK.	Quercetin	0-9	Eph receptor B1	Rattus norvegicus	134-137
34040433-14	2021	Quercetin alleviates neuralgia in CCI rats by activating AMPK pathway and inhibiting MAPK pathway and its downstream targets, p-38, p-ERK, and p-JNK.	Quercetin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	145-148
34028050-2	2021	Herein, screening and identifying of alpha-glucosidase inhibitors from hawthorn berry were conducted, and the results showed polyphenols mainly containing quercetin (74.58%) and hyperioside (9.58%) were responsible for its bioactivity.	Quercetin	155-164	sucrase isomaltase (alpha-glucosidase)	Mus musculus	37-54
33745981-0	2021	Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/ BDNF signaling pathway.	Quercetin	0-9	forkhead box G1	Mus musculus	137-142
33745981-0	2021	Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/ BDNF signaling pathway.	Quercetin	0-9	cAMP responsive element binding protein 1	Mus musculus	143-147
33745981-0	2021	Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/ BDNF signaling pathway.	Quercetin	0-9	brain derived neurotrophic factor	Mus musculus	149-153
33745981-3	2021	In this study, we explored whether quercetin plays an anti-depressant role via regulation of FoxG1 signaling in mice and revealed the potential mechanisms.	Quercetin	35-44	forkhead box G1	Mus musculus	93-98
33745981-7	2021	Furthermore, FoxG1-siRNA was employed and then stimulated with quercetin to further investigate the mechanism by which FoxG1 participates in the antidepressant effects of quercetin.	Quercetin	63-72	forkhead box G1	Mus musculus	13-18
33745981-7	2021	Furthermore, FoxG1-siRNA was employed and then stimulated with quercetin to further investigate the mechanism by which FoxG1 participates in the antidepressant effects of quercetin.	Quercetin	171-180	forkhead box G1	Mus musculus	119-124
33745981-8	2021	Our results indicate that chronic quercetin treatment dramatically increased the number of doublecortin (DCX)-positive and BrdU/NeuN-double positive cells.	Quercetin	34-43	doublecortin	Mus musculus	105-108
33745981-8	2021	Our results indicate that chronic quercetin treatment dramatically increased the number of doublecortin (DCX)-positive and BrdU/NeuN-double positive cells.	Quercetin	34-43	RNA binding protein, fox-1 homolog (C. elegans) 3	Mus musculus	128-132
33745981-9	2021	Besides, the expression levels of FoxG1, p-CREB and Brain-derived neurotrophic factor (BDNF) were also enhanced by quercetin in the DG.	Quercetin	115-124	forkhead box G1	Mus musculus	34-39
33745981-9	2021	Besides, the expression levels of FoxG1, p-CREB and Brain-derived neurotrophic factor (BDNF) were also enhanced by quercetin in the DG.	Quercetin	115-124	cAMP responsive element binding protein 1	Mus musculus	43-47
33745981-9	2021	Besides, the expression levels of FoxG1, p-CREB and Brain-derived neurotrophic factor (BDNF) were also enhanced by quercetin in the DG.	Quercetin	115-124	brain derived neurotrophic factor	Mus musculus	52-85
33745981-9	2021	Besides, the expression levels of FoxG1, p-CREB and Brain-derived neurotrophic factor (BDNF) were also enhanced by quercetin in the DG.	Quercetin	115-124	brain derived neurotrophic factor	Mus musculus	87-91
33745981-11	2021	Our results thus far suggest that quercetin might exert antidepressant effects via promotion of AHN by FoxG1/CREB/ BDNF signaling pathway.	Quercetin	34-43	forkhead box G1	Homo sapiens	103-108
33745981-11	2021	Our results thus far suggest that quercetin might exert antidepressant effects via promotion of AHN by FoxG1/CREB/ BDNF signaling pathway.	Quercetin	34-43	cAMP responsive element binding protein 1	Homo sapiens	109-113
33745981-11	2021	Our results thus far suggest that quercetin might exert antidepressant effects via promotion of AHN by FoxG1/CREB/ BDNF signaling pathway.	Quercetin	34-43	brain derived neurotrophic factor	Homo sapiens	115-119
34040433-12	2021	In addition, the analgesic effect of que was abolished when the AMPK inhibitor was added.	Quercetin	37-40	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	64-68
34040433-14	2021	Quercetin alleviates neuralgia in CCI rats by activating AMPK pathway and inhibiting MAPK pathway and its downstream targets, p-38, p-ERK, and p-JNK.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	57-61
34001136-2	2021	EXPERIMENTAL: DESIGN: We bioengineered neuron-targeting exosomes (Exo) conjugated to a monoclonal antibody against GAP43 (mAb GAP43) to promote the targeted delivery of quercetin (Que) to ischemic neurons with high GAP43 expression and investigated the ability of Exo to treat cerebral ischemia by scavenging reactive oxygen species (ROS).	Quercetin	169-178	growth associated protein 43	Rattus norvegicus	115-120
34001136-2	2021	EXPERIMENTAL: DESIGN: We bioengineered neuron-targeting exosomes (Exo) conjugated to a monoclonal antibody against GAP43 (mAb GAP43) to promote the targeted delivery of quercetin (Que) to ischemic neurons with high GAP43 expression and investigated the ability of Exo to treat cerebral ischemia by scavenging reactive oxygen species (ROS).	Quercetin	169-178	growth associated protein 43	Rattus norvegicus	126-131
34001136-2	2021	EXPERIMENTAL: DESIGN: We bioengineered neuron-targeting exosomes (Exo) conjugated to a monoclonal antibody against GAP43 (mAb GAP43) to promote the targeted delivery of quercetin (Que) to ischemic neurons with high GAP43 expression and investigated the ability of Exo to treat cerebral ischemia by scavenging reactive oxygen species (ROS).	Quercetin	169-178	growth associated protein 43	Rattus norvegicus	126-131
34001136-2	2021	EXPERIMENTAL: DESIGN: We bioengineered neuron-targeting exosomes (Exo) conjugated to a monoclonal antibody against GAP43 (mAb GAP43) to promote the targeted delivery of quercetin (Que) to ischemic neurons with high GAP43 expression and investigated the ability of Exo to treat cerebral ischemia by scavenging reactive oxygen species (ROS).	Quercetin	180-183	growth associated protein 43	Rattus norvegicus	115-120
34001136-2	2021	EXPERIMENTAL: DESIGN: We bioengineered neuron-targeting exosomes (Exo) conjugated to a monoclonal antibody against GAP43 (mAb GAP43) to promote the targeted delivery of quercetin (Que) to ischemic neurons with high GAP43 expression and investigated the ability of Exo to treat cerebral ischemia by scavenging reactive oxygen species (ROS).	Quercetin	180-183	growth associated protein 43	Rattus norvegicus	126-131
34001136-2	2021	EXPERIMENTAL: DESIGN: We bioengineered neuron-targeting exosomes (Exo) conjugated to a monoclonal antibody against GAP43 (mAb GAP43) to promote the targeted delivery of quercetin (Que) to ischemic neurons with high GAP43 expression and investigated the ability of Exo to treat cerebral ischemia by scavenging reactive oxygen species (ROS).	Quercetin	180-183	growth associated protein 43	Rattus norvegicus	126-131
34055010-11	2021	Further verification based on molecular docking results showed that NOS3 had the good binding ability with quercetin and luteolin.	Quercetin	107-116	nitric oxide synthase 3	Rattus norvegicus	68-72
33993191-13	2021	Exposure of T2D and IGT-derived MSCs to the anti-inflammatory flavonoid quercetin reduced TNFalpha levels and was paralleled by a significant decrease of the secretion of inflammatory cytokines.	Quercetin	72-81	tumor necrosis factor	Homo sapiens	90-98
33737009-1	2021	Earlier we have shown that certain flavonoids (e.g., quercetin) are high-affinity reducing cosubstrates for cyclooxygenase (COX) 1 and 2.	Quercetin	53-62	prostaglandin-endoperoxide synthase 1	Homo sapiens	108-136
33737009-6	2021	Further experimental studies confirm that galangin can inhibit, both in vitro and in vivo, quercetin-mediated activation of the peroxidase activity of the COX-1/2 enzymes.	Quercetin	91-100	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	155-162
34026648-11	2021	It mediates MDR mainly through the action of quercetin and diosgenin on the PI3K/AKT signaling pathway.	Quercetin	45-54	AKT serine/threonine kinase 1	Homo sapiens	81-84
34027151-0	2021	Quercetin upregulates CREM gene expression in cyanide-induced endocrine dysfunction.	Quercetin	0-9	cAMP responsive element modulator	Rattus norvegicus	22-26
34025416-10	2021	By recognizing the five compounds related to the ESR1 and IGF1, which are Quercetin, kaempferol, Luteolin, Apigenin, and Emodin.	Quercetin	74-83	estrogen receptor 1	Homo sapiens	49-53
34025416-10	2021	By recognizing the five compounds related to the ESR1 and IGF1, which are Quercetin, kaempferol, Luteolin, Apigenin, and Emodin.	Quercetin	74-83	insulin like growth factor 1	Homo sapiens	58-62
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	Quercetin	49-58	vascular endothelial growth factor A	Homo sapiens	152-157
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	Quercetin	49-58	interleukin 6	Homo sapiens	159-162
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	Quercetin	49-58	tumor necrosis factor	Homo sapiens	164-167
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	Quercetin	49-58	AKT serine/threonine kinase 1	Homo sapiens	169-173
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	Quercetin	49-58	tumor protein p53	Homo sapiens	179-183
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	Quercetin	49-58	tumor necrosis factor	Homo sapiens	204-207
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	Quercetin	42-51	vascular endothelial growth factor A	Homo sapiens	142-147
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	Quercetin	42-51	interleukin 6	Homo sapiens	149-152
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	Quercetin	42-51	tumor necrosis factor	Homo sapiens	154-157
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	Quercetin	42-51	AKT serine/threonine kinase 1	Homo sapiens	159-163
34027151-13	2021	Significant down-regulation of CREM gene and reduction in serum level of follicle stimulating hormone (FSH), Luteinizing hormone (LH), testosterone, glutathione peroxidase (GPx) and zinc in cyanide-treated groups, whereas administration of quercetin concomitantly with cyanide exposure or post-treated significantly reversed the alterations.	Quercetin	240-249	cAMP responsive element modulator	Rattus norvegicus	31-35
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	Quercetin	42-51	tumor protein p53	Homo sapiens	169-173
33682294-6	2021	Daidzein/quercetin and isorhamnetin/formononetin had the highest binding affinity for HER2 and PD-L1, with Kd values of 3.7 mumol/L and 490, 667, and 355 nmol/L, respectively.	Quercetin	9-18	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-90
33682294-9	2021	Enzyme activity assays showed that quercetin could inhibit the activity of HER2 with an IC50 of 570.07 nmol/L.	Quercetin	35-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	75-79
33951501-6	2021	In the piglet model, quercetin partially overrode the reduction of HIF-1alpha mRNA levels in the cortex induced by asphyxia.	Quercetin	21-30	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	67-77
33951501-7	2021	Quercetin administration also reduced increased level of HO-1 mRNA in asphyctic piglets.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	57-61
33951501-8	2021	These results suggest that quercetin neuroprotection might be involved in the regulation of HIF-1alpha, HO-1 and their targets.	Quercetin	27-36	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	92-102
33951501-8	2021	These results suggest that quercetin neuroprotection might be involved in the regulation of HIF-1alpha, HO-1 and their targets.	Quercetin	27-36	heme oxygenase 1	Rattus norvegicus	104-108
33682294-6	2021	Daidzein/quercetin and isorhamnetin/formononetin had the highest binding affinity for HER2 and PD-L1, with Kd values of 3.7 mumol/L and 490, 667, and 355 nmol/L, respectively.	Quercetin	9-18	CD274 molecule	Homo sapiens	95-100
33682294-7	2021	Molecular dynamics simulation studies based on the docking complex structures as the initial conformation yielded the binding free energy between daidzein/quercetin with HER2 and isorhamnetin/formononetin with PD-L1, calculated by molecular mechanics Poisson-Boltzmann surface area, of -26.55, -14.18, -19.41, and -11.86 kcal/mol, respectively, and were consistent with the MST results.	Quercetin	155-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	170-174
33709560-0	2021	Quercetin induces pro-apoptotic autophagy via SIRT1/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro.	Quercetin	0-9	sirtuin 1	Homo sapiens	46-51
33742251-5	2021	Firing rates of motor units recruited at 30-50% of the maximal voluntary contraction torque (MVC) were increased from PRE to POST only with quercetin (9.0 +- 2.3 to 10.5 +- 2.0 pps, p = 0.034).	Quercetin	140-149	solute carrier family 35 member G1	Homo sapiens	125-129
33158717-10	2021	Quercetin, wogonin, and polydatin bind directly to the main protease (Mpro) of SARS-CoV-2.	Quercetin	0-9	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	70-74
34012318-0	2021	Quercetin prevents myocardial infarction adverse remodeling in rats by attenuating TGF-beta1/Smad3 signaling: Different mechanisms of action.	Quercetin	0-9	transforming growth factor, beta 1	Rattus norvegicus	83-92
34012318-0	2021	Quercetin prevents myocardial infarction adverse remodeling in rats by attenuating TGF-beta1/Smad3 signaling: Different mechanisms of action.	Quercetin	0-9	SMAD family member 3	Rattus norvegicus	93-98
33191068-12	2021	In addition, the SPR experiments revealed that the quercetin and isoquercitrin were combined with SARS-CoV-2 Spike protein rather than Angiotensin-converting enzyme 2, while astragaloside IV and rutin were combined with ACE2 rather than SARS-CoV-2 Spike protein.	Quercetin	51-60	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	109-114
33191068-12	2021	In addition, the SPR experiments revealed that the quercetin and isoquercitrin were combined with SARS-CoV-2 Spike protein rather than Angiotensin-converting enzyme 2, while astragaloside IV and rutin were combined with ACE2 rather than SARS-CoV-2 Spike protein.	Quercetin	51-60	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	248-253
33709560-0	2021	Quercetin induces pro-apoptotic autophagy via SIRT1/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	52-56
33709560-9	2021	Moreover, quercetin also promoted the expression of LC3-II and beclin 1 and suppressed the expression of p62.	Quercetin	10-19	beclin 1	Homo sapiens	63-71
33709560-9	2021	Moreover, quercetin also promoted the expression of LC3-II and beclin 1 and suppressed the expression of p62.	Quercetin	10-19	nucleoporin 62	Homo sapiens	105-108
33709560-10	2021	The mRNA levels of LC3-II, beclin 1, Atg5, Atg7, and Atg12 were upregulated by quercetin treatment.	Quercetin	79-88	beclin 1	Homo sapiens	27-35
33709560-10	2021	The mRNA levels of LC3-II, beclin 1, Atg5, Atg7, and Atg12 were upregulated by quercetin treatment.	Quercetin	79-88	autophagy related 5	Homo sapiens	37-41
33709560-10	2021	The mRNA levels of LC3-II, beclin 1, Atg5, Atg7, and Atg12 were upregulated by quercetin treatment.	Quercetin	79-88	autophagy related 7	Homo sapiens	43-47
33709560-10	2021	The mRNA levels of LC3-II, beclin 1, Atg5, Atg7, and Atg12 were upregulated by quercetin treatment.	Quercetin	79-88	autophagy related 12	Homo sapiens	53-58
33709560-12	2021	In addition, quercetin dose-dependently elevated the levels of SIRT1 protein and the pAMPK-AMPK ratio.	Quercetin	13-22	sirtuin 1	Homo sapiens	63-68
33709560-13	2021	Quercetin-induced autophagy was attenuated by SIRT1 inhibitor EX527 and SirT1 knockdown by small interfering RNA (siRNA).	Quercetin	0-9	sirtuin 1	Homo sapiens	46-51
33709560-13	2021	Quercetin-induced autophagy was attenuated by SIRT1 inhibitor EX527 and SirT1 knockdown by small interfering RNA (siRNA).	Quercetin	0-9	sirtuin 1	Homo sapiens	72-77
33709560-14	2021	CONCLUSIONS: Quercetin-induced autophagy contributes to apoptosis in A549 and H1299 lung cancer cells, which involved the SIRT1/AMPK signaling pathway.	Quercetin	13-22	sirtuin 1	Homo sapiens	122-127
33709560-14	2021	CONCLUSIONS: Quercetin-induced autophagy contributes to apoptosis in A549 and H1299 lung cancer cells, which involved the SIRT1/AMPK signaling pathway.	Quercetin	13-22	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	128-132
33996881-9	2021	Moreover, this study finds dietary quercetin could modulate MSG-induced gut microbiota dysbiosis, alleviate hypothalamic damage and down-regulate liver RetSat expression, thus ameliorating abdominal obesity.	Quercetin	35-44	retinol saturase (all trans retinol 13,14 reductase)	Mus musculus	152-158
33909098-0	2021	Correction to: Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-alpha and translocating PKC-delta.	Quercetin	69-78	protein kinase C, alpha	Mus musculus	128-137
33908633-0	2021	Quercetin Relieves D-Amphetamine induced Manic-like Behavior through Activating TREK-1 Potassium Channels in Mice.	Quercetin	0-9	potassium channel, subfamily K, member 2	Mus musculus	80-86
33909098-0	2021	Correction to: Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-alpha and translocating PKC-delta.	Quercetin	69-78	protein kinase C, delta	Mus musculus	156-165
33908633-9	2021	Spadin, a TREK-1 potassium channel (a two-pore-domain background potassium channel) inhibitor, could block the effect of quercetin on the membrane resistance and neuronal firing.	Quercetin	121-130	potassium channel, subfamily K, member 2	Mus musculus	10-16
33908633-11	2021	Moreover, the effect of quercetin on TREK-1 channel could be mimicked by GF109203X, a protein kinase C inhibitor.	Quercetin	24-33	potassium channel, subfamily K, member 2	Mus musculus	37-43
33908633-13	2021	CONCLUSION AND IMPLICATIONS: Our results demonstrated that TREK-1 channel is a novel target on quercetin treatment through PKC-dependent manner, which could contribute to both the neuroprotection and anti-manic-like effects.	Quercetin	95-104	potassium channel, subfamily K, member 2	Mus musculus	59-65
33962176-13	2021	The decreased protein levels of VEGF-A, MMP9, and MMP2 were observed at the 10 mug/mL quercetin group.	Quercetin	86-95	vascular endothelial growth factor A	Homo sapiens	32-38
33962176-13	2021	The decreased protein levels of VEGF-A, MMP9, and MMP2 were observed at the 10 mug/mL quercetin group.	Quercetin	86-95	matrix metallopeptidase 9	Homo sapiens	40-44
33962176-13	2021	The decreased protein levels of VEGF-A, MMP9, and MMP2 were observed at the 10 mug/mL quercetin group.	Quercetin	86-95	matrix metallopeptidase 2	Homo sapiens	50-54
33962176-14	2021	CONCLUSION: Quercetin suppressed the invasion and angiogenesis of esophageal cancer cells, and the effects were associated with the decreased expression of VEGF-A, MMP2, and MMP9.	Quercetin	12-21	vascular endothelial growth factor A	Homo sapiens	156-162
33962176-14	2021	CONCLUSION: Quercetin suppressed the invasion and angiogenesis of esophageal cancer cells, and the effects were associated with the decreased expression of VEGF-A, MMP2, and MMP9.	Quercetin	12-21	matrix metallopeptidase 2	Homo sapiens	164-168
33962176-14	2021	CONCLUSION: Quercetin suppressed the invasion and angiogenesis of esophageal cancer cells, and the effects were associated with the decreased expression of VEGF-A, MMP2, and MMP9.	Quercetin	12-21	matrix metallopeptidase 9	Homo sapiens	174-178
33878030-4	2021	In vitro, we found that quercetin (20 muM) treatment improved mitochondrial quality control, reduced oxidative stress, increased the levels of the mitophagy markers PINK1 and Parkin and decreased alpha-synuclein protein expression in 6-OHDA-treated PC12 cells.	Quercetin	24-33	PTEN induced kinase 1	Rattus norvegicus	165-170
33968984-9	2021	Molecular docking results suggest that each bioactive compounds (quercetin, wogonin, luteolin, naringenin, and kaempferol) is capable to bind with STAT3, PTGS2, JUN, VEGFA, EGFR, and ALOX5.	Quercetin	65-74	signal transducer and activator of transcription 3	Homo sapiens	147-152
33968984-9	2021	Molecular docking results suggest that each bioactive compounds (quercetin, wogonin, luteolin, naringenin, and kaempferol) is capable to bind with STAT3, PTGS2, JUN, VEGFA, EGFR, and ALOX5.	Quercetin	65-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	154-159
33968984-9	2021	Molecular docking results suggest that each bioactive compounds (quercetin, wogonin, luteolin, naringenin, and kaempferol) is capable to bind with STAT3, PTGS2, JUN, VEGFA, EGFR, and ALOX5.	Quercetin	65-74	vascular endothelial growth factor A	Homo sapiens	166-171
33968984-9	2021	Molecular docking results suggest that each bioactive compounds (quercetin, wogonin, luteolin, naringenin, and kaempferol) is capable to bind with STAT3, PTGS2, JUN, VEGFA, EGFR, and ALOX5.	Quercetin	65-74	epidermal growth factor receptor	Homo sapiens	173-177
33968984-9	2021	Molecular docking results suggest that each bioactive compounds (quercetin, wogonin, luteolin, naringenin, and kaempferol) is capable to bind with STAT3, PTGS2, JUN, VEGFA, EGFR, and ALOX5.	Quercetin	65-74	arachidonate 5-lipoxygenase	Homo sapiens	183-188
33946222-13	2021	This was supported by the micromolar/submicromolar affinity of quercetin towards proto-oncogene serine/threonine-protein kinase (PIM-1) and hematopoietic cell kinase (HCK), both involved in breast cancer.	Quercetin	63-72	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	129-134
33946222-13	2021	This was supported by the micromolar/submicromolar affinity of quercetin towards proto-oncogene serine/threonine-protein kinase (PIM-1) and hematopoietic cell kinase (HCK), both involved in breast cancer.	Quercetin	63-72	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	140-165
33946222-13	2021	This was supported by the micromolar/submicromolar affinity of quercetin towards proto-oncogene serine/threonine-protein kinase (PIM-1) and hematopoietic cell kinase (HCK), both involved in breast cancer.	Quercetin	63-72	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	167-170
33892727-0	2021	Quercetin prevents primordial follicle loss via suppression of PI3K/Akt/Foxo3a pathway activation in cyclophosphamide-treated mice.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	68-71
33892727-0	2021	Quercetin prevents primordial follicle loss via suppression of PI3K/Akt/Foxo3a pathway activation in cyclophosphamide-treated mice.	Quercetin	0-9	forkhead box O3	Mus musculus	72-78
33892727-11	2021	Analysis of the PI3K/Akt/Foxo3a pathway showed that quercetin decreased the phosphorylation of proteins that stimulate follicle activation in cyclophosphamide-induced ovaries.	Quercetin	52-61	thymoma viral proto-oncogene 1	Mus musculus	21-24
33892727-11	2021	Analysis of the PI3K/Akt/Foxo3a pathway showed that quercetin decreased the phosphorylation of proteins that stimulate follicle activation in cyclophosphamide-induced ovaries.	Quercetin	52-61	forkhead box O3	Mus musculus	25-31
33892727-12	2021	Furthermore, quercetin prevented cyclophosphamide-induced apoptosis in early growing follicles and early antral follicles, maintained anti-Mullerian hormone levels secreted by these follicles, and preserved the quiescence of the primordial follicle pool, as determined by intranuclear Foxo3a staining.	Quercetin	13-22	forkhead box O3	Mus musculus	285-291
33892727-13	2021	CONCLUSIONS: Quercetin attenuates cyclophosphamide-induced follicle loss by preventing the phosphorylation of PI3K/Akt/Foxo3a pathway members and maintaining the anti-Mullerian hormone level through reduced apoptosis in growing follicles.	Quercetin	13-22	thymoma viral proto-oncogene 1	Mus musculus	115-118
33892727-13	2021	CONCLUSIONS: Quercetin attenuates cyclophosphamide-induced follicle loss by preventing the phosphorylation of PI3K/Akt/Foxo3a pathway members and maintaining the anti-Mullerian hormone level through reduced apoptosis in growing follicles.	Quercetin	13-22	forkhead box O3	Mus musculus	119-125
33878030-4	2021	In vitro, we found that quercetin (20 muM) treatment improved mitochondrial quality control, reduced oxidative stress, increased the levels of the mitophagy markers PINK1 and Parkin and decreased alpha-synuclein protein expression in 6-OHDA-treated PC12 cells.	Quercetin	24-33	synuclein alpha	Rattus norvegicus	196-211
33878030-5	2021	Moreover, our in vivo findings demonstrated that administration of quercetin also relieved 6-OHDA-induced progressive PD-like motor behaviors, mitigated neuronal death and reduced mitochondrial damage and alpha-synuclein accumulation in PD rats.	Quercetin	67-76	synuclein alpha	Rattus norvegicus	205-220
33878030-6	2021	Furthermore, the neuroprotective effect of quercetin was suppressed by knockdown of either Pink1 or Parkin.	Quercetin	43-52	PTEN induced kinase 1	Rattus norvegicus	91-96
33577840-4	2021	Quercetin treatment at 50 muM and 75 muM concentration inhibit human metastatic ovarian cancer PA-1 cell survival and proliferation via inactivating PI3k/Akt, Ras/Raf pathways and EGFR expression.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	154-157
33923988-0	2021	Novel Quercetin Derivative of 3,7-Dioleylquercetin Shows Less Toxicity and Highly Potent Tyrosinase Inhibition Activity.	Quercetin	6-15	tyrosinase	Danio rerio	89-99
33923988-1	2021	Quercetin is a well-known plant flavonol and antioxidant; however, there has been some debate regarding the efficacy and safety of native quercetin as a skin-whitening agent via tyrosinase inhibition.	Quercetin	138-147	tyrosinase	Danio rerio	178-188
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	Quercetin	30-39	Janus kinase 2	Homo sapiens	203-208
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	Quercetin	30-39	signal transducer and activator of transcription 3	Homo sapiens	209-215
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	Quercetin	30-39	cyclin D1	Homo sapiens	263-272
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	Quercetin	30-39	BCL2 apoptosis regulator	Homo sapiens	277-282
33920726-12	2021	It is noteworthy to mention that quercetin acts as both SIRT6 activator and inhibitor depending on its concentration used.	Quercetin	33-42	sirtuin 6	Homo sapiens	56-61
33577840-6	2021	Quercetin also decreases the secretion of gelatinase enzyme, proteolytic activity of MMP-2/-9, and both MMPs gene expression in metastatic ovarian cancer PA-1 cells.	Quercetin	0-9	matrix metallopeptidase 2	Homo sapiens	85-93
33577840-6	2021	Quercetin also decreases the secretion of gelatinase enzyme, proteolytic activity of MMP-2/-9, and both MMPs gene expression in metastatic ovarian cancer PA-1 cells.	Quercetin	0-9	matrix metallopeptidase 2	Homo sapiens	104-108
33577840-8	2021	Treatment of quercetin with PA-1 cells also downregulates the tight junctional molecules such as Claudin-4 and Claudin-11 while upregulates the expression of occludin.	Quercetin	13-22	claudin 4	Homo sapiens	97-106
33577840-4	2021	Quercetin treatment at 50 muM and 75 muM concentration inhibit human metastatic ovarian cancer PA-1 cell survival and proliferation via inactivating PI3k/Akt, Ras/Raf pathways and EGFR expression.	Quercetin	0-9	epidermal growth factor receptor	Homo sapiens	180-184
33847382-4	2021	In this study, we observed that seabuckthorn and its flavonoid compounds quercetin and isorhamnetin were shown strong retention to ACE2 overexpression HEK293 (ACE2h ) cells by CMC analysis.	Quercetin	73-82	angiotensin converting enzyme 2	Homo sapiens	131-135
33577840-8	2021	Treatment of quercetin with PA-1 cells also downregulates the tight junctional molecules such as Claudin-4 and Claudin-11 while upregulates the expression of occludin.	Quercetin	13-22	claudin 11	Homo sapiens	111-121
33577840-8	2021	Treatment of quercetin with PA-1 cells also downregulates the tight junctional molecules such as Claudin-4 and Claudin-11 while upregulates the expression of occludin.	Quercetin	13-22	occludin	Homo sapiens	158-166
33919990-5	2021	Our in vitro results indicated that quercetin protected human retinal pigment epithelium (ARPE-19) cells from NaIO3-induced apoptosis by inhibiting reactive oxygen species production and loss of mitochondrial membrane potential as detected by Annexin V-FITC/PI flow cytometry.	Quercetin	36-45	annexin A5	Homo sapiens	243-252
33919990-7	2021	Quercetin downregulated the protein expressions of Bax, cleaved caspase-3, and cleaved PARP and upregulated the expression of Bcl-2 through reduced PI3K and pAKT expressions.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54
33919990-7	2021	Quercetin downregulated the protein expressions of Bax, cleaved caspase-3, and cleaved PARP and upregulated the expression of Bcl-2 through reduced PI3K and pAKT expressions.	Quercetin	0-9	caspase 3	Homo sapiens	64-73
33919990-7	2021	Quercetin downregulated the protein expressions of Bax, cleaved caspase-3, and cleaved PARP and upregulated the expression of Bcl-2 through reduced PI3K and pAKT expressions.	Quercetin	0-9	collagen type XI alpha 2 chain	Homo sapiens	87-91
33919990-7	2021	Quercetin downregulated the protein expressions of Bax, cleaved caspase-3, and cleaved PARP and upregulated the expression of Bcl-2 through reduced PI3K and pAKT expressions.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	126-131
33919990-9	2021	Taken together, these results demonstrate that quercetin could protect retinal pigment epithelium and the retina from NaIO3-induced cell apoptosis via reactive oxygen species-mediated mitochondrial dysfunction, involving the PI3K/AKT signaling pathway.	Quercetin	47-56	AKT serine/threonine kinase 1	Homo sapiens	230-233
33918053-0	2021	Effect of Quercetin on ABCC6 Transporter: Implication in HepG2 Migration.	Quercetin	10-19	ATP binding cassette subfamily C member 6	Homo sapiens	23-28
33862555-7	2021	We detected the expression of IL-8 after treatment of quercetin using qRT-PCR and evaluated its anti-itching effect in BALB/c mice.	Quercetin	54-63	chemokine (C-X-C motif) ligand 15	Mus musculus	30-34
33862555-12	2021	Moreover, the selective TRPV1 blocker capsazepine significantly suppressed the quercetin-mediated inhibition of histamine-induced [Ca2+]i elevation, whereas the TRPV4 blocker GSK2193874 had no effect.	Quercetin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
33862555-13	2021	Last, quercetin decreased histamine and H4 agonist-induced IL-8 expression in keratinocyte and inhibited the scratching behavior-induced compound 48/80 in BALB/c mice.	Quercetin	6-15	chemokine (C-X-C motif) ligand 15	Mus musculus	59-63
33862555-15	2021	These data suggest that quercetin could decrease histamine 4 receptor-induced calcium influx through the TRPV1 channel and could provide a molecular mechanism of quercetin in anti-itching, anti-inflammatory, and unpleasant sensations.	Quercetin	24-33	transient receptor potential cation channel subfamily V member 1	Homo sapiens	105-110
33862555-15	2021	These data suggest that quercetin could decrease histamine 4 receptor-induced calcium influx through the TRPV1 channel and could provide a molecular mechanism of quercetin in anti-itching, anti-inflammatory, and unpleasant sensations.	Quercetin	162-171	transient receptor potential cation channel subfamily V member 1	Homo sapiens	105-110
33918053-3	2021	Quercetin has been also reported to modulate the activity of some members of the multidrug-resistance transporters family, such as P-gp, ABCC1, ABCC2, and ABCG2, and the activity of ecto-5"-nucleotidase (NT5E/CD73), a key regulator in some tumor processes such as invasion, migration, and metastasis.	Quercetin	0-9	phosphoglycolate phosphatase	Homo sapiens	131-135
33918053-3	2021	Quercetin has been also reported to modulate the activity of some members of the multidrug-resistance transporters family, such as P-gp, ABCC1, ABCC2, and ABCG2, and the activity of ecto-5"-nucleotidase (NT5E/CD73), a key regulator in some tumor processes such as invasion, migration, and metastasis.	Quercetin	0-9	ATP binding cassette subfamily C member 1	Homo sapiens	137-142
33918053-3	2021	Quercetin has been also reported to modulate the activity of some members of the multidrug-resistance transporters family, such as P-gp, ABCC1, ABCC2, and ABCG2, and the activity of ecto-5"-nucleotidase (NT5E/CD73), a key regulator in some tumor processes such as invasion, migration, and metastasis.	Quercetin	0-9	ATP binding cassette subfamily C member 2	Homo sapiens	144-149
33918053-3	2021	Quercetin has been also reported to modulate the activity of some members of the multidrug-resistance transporters family, such as P-gp, ABCC1, ABCC2, and ABCG2, and the activity of ecto-5"-nucleotidase (NT5E/CD73), a key regulator in some tumor processes such as invasion, migration, and metastasis.	Quercetin	0-9	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	155-160
33918053-3	2021	Quercetin has been also reported to modulate the activity of some members of the multidrug-resistance transporters family, such as P-gp, ABCC1, ABCC2, and ABCG2, and the activity of ecto-5"-nucleotidase (NT5E/CD73), a key regulator in some tumor processes such as invasion, migration, and metastasis.	Quercetin	0-9	5'-nucleotidase ecto	Homo sapiens	182-202
33918053-3	2021	Quercetin has been also reported to modulate the activity of some members of the multidrug-resistance transporters family, such as P-gp, ABCC1, ABCC2, and ABCG2, and the activity of ecto-5"-nucleotidase (NT5E/CD73), a key regulator in some tumor processes such as invasion, migration, and metastasis.	Quercetin	0-9	5'-nucleotidase ecto	Homo sapiens	204-208
33918053-4	2021	In this study, we investigated the effect of Quercetin on ABCC6 expression in HepG2 cells.	Quercetin	45-54	ATP binding cassette subfamily C member 6	Homo sapiens	58-63
33918053-10	2021	We propose that ABCC6 expression may be controlled by the AKT pathway as part of an adaptative response to oxidative stress, which can be mitigated by the use of Quercetin-like flavonoids.	Quercetin	162-171	ATP binding cassette subfamily C member 6	Homo sapiens	16-21
33918053-10	2021	We propose that ABCC6 expression may be controlled by the AKT pathway as part of an adaptative response to oxidative stress, which can be mitigated by the use of Quercetin-like flavonoids.	Quercetin	162-171	AKT serine/threonine kinase 1	Homo sapiens	58-61
33398654-0	2021	The Alleviative Effects of Quercetin on Cadmium-Induced Necroptosis via Inhibition ROS/iNOS/NF-kappaB Pathway in the Chicken Brain.	Quercetin	27-36	nitric oxide synthase 2	Gallus gallus	87-91
33918248-0	2021	Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves.	Quercetin	44-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	130-134
33918248-0	2021	Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves.	Quercetin	44-53	heme oxygenase 1	Mus musculus	139-143
33918248-8	2021	These findings suggest that isoquercitrin and quercetin are the active principles representing the protective effects of DMLE, and these effects were mediated by the Nrf2/HO-1 pathway.	Quercetin	46-55	nuclear factor, erythroid derived 2, like 2	Mus musculus	166-170
33918248-8	2021	These findings suggest that isoquercitrin and quercetin are the active principles representing the protective effects of DMLE, and these effects were mediated by the Nrf2/HO-1 pathway.	Quercetin	46-55	heme oxygenase 1	Mus musculus	171-175
33021114-6	2021	Quercetin and crocin increased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the liver and decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the kidneys.	Quercetin	0-9	annexin A3	Rattus norvegicus	58-61
33021114-7	2021	Moreover, quercetin and crocin inhibited the excessive proliferation of RMCs induced by high-glucose (HG) conditions, decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels, and decreased TGF-beta1 expression.	Quercetin	10-19	annexin A3	Rattus norvegicus	155-158
33021114-6	2021	Quercetin and crocin increased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the liver and decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the kidneys.	Quercetin	0-9	autophagy related 5	Rattus norvegicus	63-67
33021114-7	2021	Moreover, quercetin and crocin inhibited the excessive proliferation of RMCs induced by high-glucose (HG) conditions, decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels, and decreased TGF-beta1 expression.	Quercetin	10-19	autophagy related 5	Rattus norvegicus	160-164
33021114-6	2021	Quercetin and crocin increased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the liver and decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the kidneys.	Quercetin	0-9	beclin 1	Rattus norvegicus	69-77
33021114-7	2021	Moreover, quercetin and crocin inhibited the excessive proliferation of RMCs induced by high-glucose (HG) conditions, decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels, and decreased TGF-beta1 expression.	Quercetin	10-19	beclin 1	Rattus norvegicus	166-174
33021114-7	2021	Moreover, quercetin and crocin inhibited the excessive proliferation of RMCs induced by high-glucose (HG) conditions, decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels, and decreased TGF-beta1 expression.	Quercetin	10-19	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	181-185
33021114-6	2021	Quercetin and crocin increased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the liver and decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the kidneys.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	84-88
33021114-7	2021	Moreover, quercetin and crocin inhibited the excessive proliferation of RMCs induced by high-glucose (HG) conditions, decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels, and decreased TGF-beta1 expression.	Quercetin	10-19	transforming growth factor, beta 1	Rattus norvegicus	209-218
33021114-6	2021	Quercetin and crocin increased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the liver and decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the kidneys.	Quercetin	0-9	annexin A3	Rattus norvegicus	151-154
33021114-9	2021	These results suggest that combined administration of quercetin and crocin can more significantly reduce blood glucose/lipid levels and improve renal fibrosis than administration of either compound alone and that AMPK-dependent autophagy might be involved in this process.	Quercetin	54-63	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	213-217
33021114-6	2021	Quercetin and crocin increased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the liver and decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the kidneys.	Quercetin	0-9	autophagy related 5	Rattus norvegicus	156-160
33021114-6	2021	Quercetin and crocin increased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the liver and decreased autophagy-related protein (LC3, Atg5, Beclin-1 and p-AMPK) levels in the kidneys.	Quercetin	0-9	beclin 1	Rattus norvegicus	162-170
33051781-0	2021	Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1.	Quercetin	0-9	microRNA 216b	Mus musculus	75-83
33550031-9	2021	Moreover, quercetin attenuated the expression of inflammatory mediators including toll-like receptor-4 (TLR-4), TLR-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and high mobility group box 1 (HMGB1) in vitro and in vivo.	Quercetin	10-19	toll-like receptor 4	Mus musculus	104-109
33051781-0	2021	Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1.	Quercetin	0-9	mitogen-activated protein kinase kinase 6	Mus musculus	97-103
33051781-0	2021	Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1.	Quercetin	0-9	nuclear paraspeckle assembly transcript 1 (non-protein coding)	Mus musculus	108-113
33550031-9	2021	Moreover, quercetin attenuated the expression of inflammatory mediators including toll-like receptor-4 (TLR-4), TLR-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and high mobility group box 1 (HMGB1) in vitro and in vivo.	Quercetin	10-19	toll-like receptor 2	Mus musculus	112-117
33550031-9	2021	Moreover, quercetin attenuated the expression of inflammatory mediators including toll-like receptor-4 (TLR-4), TLR-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and high mobility group box 1 (HMGB1) in vitro and in vivo.	Quercetin	10-19	interleukin 1 alpha	Mus musculus	138-146
33550031-9	2021	Moreover, quercetin attenuated the expression of inflammatory mediators including toll-like receptor-4 (TLR-4), TLR-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and high mobility group box 1 (HMGB1) in vitro and in vivo.	Quercetin	10-19	tumor necrosis factor	Mus musculus	178-187
33550031-9	2021	Moreover, quercetin attenuated the expression of inflammatory mediators including toll-like receptor-4 (TLR-4), TLR-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and high mobility group box 1 (HMGB1) in vitro and in vivo.	Quercetin	10-19	high mobility group box 1	Mus musculus	220-225
33537804-0	2021	Quercetin reverses TNF-alpha induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF-kappaB/NLRP3 inflammasome pathway.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	19-28
33537804-0	2021	Quercetin reverses TNF-alpha induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF-kappaB/NLRP3 inflammasome pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	115-124
33537804-0	2021	Quercetin reverses TNF-alpha induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF-kappaB/NLRP3 inflammasome pathway.	Quercetin	0-9	NLR family pyrin domain containing 3	Homo sapiens	125-130
33550031-10	2021	CONCLUSIONS: Our study demonstrated that quercetin treatment can ameliorate A. fumigatus keratitis by inhibiting the growth of A. fumigatus, decreasing neutrophil recruitment and infiltration, and downregulating the productions of TLR-4, TLR-2, TNF-alpha, IL-1beta and HMGB1, indicating quercetin is likely to become a potential therapeutic agent in FK treatment.	Quercetin	41-50	toll-like receptor 4	Mus musculus	231-236
33550031-10	2021	CONCLUSIONS: Our study demonstrated that quercetin treatment can ameliorate A. fumigatus keratitis by inhibiting the growth of A. fumigatus, decreasing neutrophil recruitment and infiltration, and downregulating the productions of TLR-4, TLR-2, TNF-alpha, IL-1beta and HMGB1, indicating quercetin is likely to become a potential therapeutic agent in FK treatment.	Quercetin	41-50	toll-like receptor 2	Mus musculus	238-243
33550031-10	2021	CONCLUSIONS: Our study demonstrated that quercetin treatment can ameliorate A. fumigatus keratitis by inhibiting the growth of A. fumigatus, decreasing neutrophil recruitment and infiltration, and downregulating the productions of TLR-4, TLR-2, TNF-alpha, IL-1beta and HMGB1, indicating quercetin is likely to become a potential therapeutic agent in FK treatment.	Quercetin	41-50	tumor necrosis factor	Mus musculus	245-254
33550031-10	2021	CONCLUSIONS: Our study demonstrated that quercetin treatment can ameliorate A. fumigatus keratitis by inhibiting the growth of A. fumigatus, decreasing neutrophil recruitment and infiltration, and downregulating the productions of TLR-4, TLR-2, TNF-alpha, IL-1beta and HMGB1, indicating quercetin is likely to become a potential therapeutic agent in FK treatment.	Quercetin	41-50	interleukin 1 alpha	Mus musculus	256-264
33550031-10	2021	CONCLUSIONS: Our study demonstrated that quercetin treatment can ameliorate A. fumigatus keratitis by inhibiting the growth of A. fumigatus, decreasing neutrophil recruitment and infiltration, and downregulating the productions of TLR-4, TLR-2, TNF-alpha, IL-1beta and HMGB1, indicating quercetin is likely to become a potential therapeutic agent in FK treatment.	Quercetin	41-50	high mobility group box 1	Mus musculus	269-274
33216421-7	2021	TNF-alpha levels significantly decreased in the quercetin group (p = .009); this was not, however, significant compared to the placebo group.	Quercetin	48-57	tumor necrosis factor	Homo sapiens	0-9
33625428-5	2021	Different spectroscopic measurements demonstrated that trilobatin could change the microenvironments and conformation of tyrosinase and molecular docking determined the binding site of quercetin on tyrosinase.	Quercetin	185-194	tyrosinase	Homo sapiens	121-131
33350534-8	2021	Quercetin pretreatment ameliorates DMH-induced proliferation, activities of detoxifying enzymes, and putative early markers (mucin depletion and goblet cell disintegration) in colonic tissue.	Quercetin	0-9	solute carrier family 13 member 2	Rattus norvegicus	125-130
33860002-0	2021	Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases.	Quercetin	25-34	renin binding protein	Homo sapiens	75-78
33860002-9	2021	A growing body of evidence suggests quercetin could lower the risk of IHD by mitigating endothelial dysfunction and its risk factors, such as hypertension, atherosclerosis, accumulation of senescent endothelial cells, and endothelial-mesenchymal transition (EndoMT).	Quercetin	36-45	mannosidase endo-alpha	Homo sapiens	258-264
33860002-11	2021	We will then present the scientific evidence to quercetin"s anti-atherosclerotic, anti-hypertensive, senolytic, and anti-EndoMT effects.	Quercetin	48-57	mannosidase endo-alpha	Homo sapiens	121-127
33859776-0	2021	Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress.	Quercetin	0-9	sirtuin 1	Homo sapiens	72-77
33859776-0	2021	Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress.	Quercetin	0-9	transmembrane BAX inhibitor motif containing 6	Homo sapiens	78-84
33859776-8	2021	Quercetin pretreatment inhibited H/R-mediated overproduction of reactive oxygen species and damage caused by oxidative stress, increased mitophagy, regulated mRNA and protein expression of transmembrane BAX inhibitor-1 motif-containing 6 (TMBIM6), regulated endoplasmic reticulum stress, and improved the vulnerability of human cardiomyocytes to H/R.	Quercetin	0-9	transmembrane BAX inhibitor motif containing 6	Homo sapiens	189-237
33859776-8	2021	Quercetin pretreatment inhibited H/R-mediated overproduction of reactive oxygen species and damage caused by oxidative stress, increased mitophagy, regulated mRNA and protein expression of transmembrane BAX inhibitor-1 motif-containing 6 (TMBIM6), regulated endoplasmic reticulum stress, and improved the vulnerability of human cardiomyocytes to H/R.	Quercetin	0-9	transmembrane BAX inhibitor motif containing 6	Homo sapiens	239-245
33859776-9	2021	Furthermore, transfection with short interfering RNA against silent information regulator protein 1 (SIRT1) counteracted the protective effects of quercetin on cardiomyocytes.	Quercetin	147-156	sirtuin 1	Homo sapiens	61-99
33859776-9	2021	Furthermore, transfection with short interfering RNA against silent information regulator protein 1 (SIRT1) counteracted the protective effects of quercetin on cardiomyocytes.	Quercetin	147-156	sirtuin 1	Homo sapiens	101-106
33859776-10	2021	Thus, quercetin was predicted to regulate mitophagy and endoplasmic reticulum stress through SIRT1/TMBIM6 and inhibit H/R-induced oxidative stress damage.	Quercetin	6-15	sirtuin 1	Homo sapiens	93-98
33859776-10	2021	Thus, quercetin was predicted to regulate mitophagy and endoplasmic reticulum stress through SIRT1/TMBIM6 and inhibit H/R-induced oxidative stress damage.	Quercetin	6-15	transmembrane BAX inhibitor motif containing 6	Homo sapiens	99-105
33186701-0	2021	Quercetin Mitigates Ethanol-Induced Hepatic Steatosis in Zebrafish via P2X7R-mediated PI3K/ Keap1/Nrf2 Signaling Pathway.	Quercetin	0-9	kelch-like ECH-associated protein 1a	Danio rerio	92-97
33186701-0	2021	Quercetin Mitigates Ethanol-Induced Hepatic Steatosis in Zebrafish via P2X7R-mediated PI3K/ Keap1/Nrf2 Signaling Pathway.	Quercetin	0-9	nfe2 like bZIP transcription factor 2a	Danio rerio	98-102
33186701-8	2021	Additionally, quercetin significantly reduced the MDA content and suppressed the ethanol-induced reduction of hepatic oxidative stress biomarkers GSH, CAT and SOD and significantly down-regulated the expression of P2X7R, and up-regulated the expression of phosphatidylinositol 3-kinase (PI3K), Kelch like ECH associated protein1 (Keap1), Nuclear Factor E2 related factor 2 (Nrf2).	Quercetin	14-23	catalase	Danio rerio	151-162
33186701-8	2021	Additionally, quercetin significantly reduced the MDA content and suppressed the ethanol-induced reduction of hepatic oxidative stress biomarkers GSH, CAT and SOD and significantly down-regulated the expression of P2X7R, and up-regulated the expression of phosphatidylinositol 3-kinase (PI3K), Kelch like ECH associated protein1 (Keap1), Nuclear Factor E2 related factor 2 (Nrf2).	Quercetin	14-23	kelch-like ECH-associated protein 1a	Danio rerio	294-328
33186701-8	2021	Additionally, quercetin significantly reduced the MDA content and suppressed the ethanol-induced reduction of hepatic oxidative stress biomarkers GSH, CAT and SOD and significantly down-regulated the expression of P2X7R, and up-regulated the expression of phosphatidylinositol 3-kinase (PI3K), Kelch like ECH associated protein1 (Keap1), Nuclear Factor E2 related factor 2 (Nrf2).	Quercetin	14-23	kelch-like ECH-associated protein 1a	Danio rerio	330-335
33186701-8	2021	Additionally, quercetin significantly reduced the MDA content and suppressed the ethanol-induced reduction of hepatic oxidative stress biomarkers GSH, CAT and SOD and significantly down-regulated the expression of P2X7R, and up-regulated the expression of phosphatidylinositol 3-kinase (PI3K), Kelch like ECH associated protein1 (Keap1), Nuclear Factor E2 related factor 2 (Nrf2).	Quercetin	14-23	nfe2 like bZIP transcription factor 2a	Danio rerio	374-378
33186701-10	2021	CONCLUSION: Quercetin exhibited hepatoprotective capacity in zebrafish model, via regulating P2X7R-mediated PI3K/Keap1/Nrf2 oxidative stress signaling pathway.	Quercetin	12-21	kelch-like ECH-associated protein 1a	Danio rerio	113-118
33186701-10	2021	CONCLUSION: Quercetin exhibited hepatoprotective capacity in zebrafish model, via regulating P2X7R-mediated PI3K/Keap1/Nrf2 oxidative stress signaling pathway.	Quercetin	12-21	nfe2 like bZIP transcription factor 2a	Danio rerio	119-123
33667291-0	2021	Quercetin regulates skeletal muscle fiber type switching via adiponectin signaling.	Quercetin	0-9	adiponectin, C1Q and collagen domain containing	Mus musculus	61-72
33667291-3	2021	By contrast, quercetin decreased lactate dehydrogenase (LDH) activity, fast MyHC protein expression, fast-twitch fiber percentage, and MyHC IIb mRNA expression.	Quercetin	13-22	myosin, heavy polypeptide 4, skeletal muscle	Mus musculus	135-143
33667291-4	2021	Furthermore, quercetin significantly increased serum adiponectin (AdipoQ) concentration, and the expression levels of AdipoQ and AdipoR1.	Quercetin	13-22	adiponectin, C1Q and collagen domain containing	Mus musculus	53-64
33667291-4	2021	Furthermore, quercetin significantly increased serum adiponectin (AdipoQ) concentration, and the expression levels of AdipoQ and AdipoR1.	Quercetin	13-22	adiponectin, C1Q and collagen domain containing	Mus musculus	66-72
33667291-4	2021	Furthermore, quercetin significantly increased serum adiponectin (AdipoQ) concentration, and the expression levels of AdipoQ and AdipoR1.	Quercetin	13-22	adiponectin, C1Q and collagen domain containing	Mus musculus	118-124
33350534-0	2021	Quercetin ameliorates reactive oxygen species generation, inflammation, mucus depletion, goblet disintegration, and tumor multiplicity in colon cancer: Probable role of adenomatous polyposis coli, beta-catenin.	Quercetin	0-9	APC regulator of WNT signaling pathway	Rattus norvegicus	169-195
33350534-0	2021	Quercetin ameliorates reactive oxygen species generation, inflammation, mucus depletion, goblet disintegration, and tumor multiplicity in colon cancer: Probable role of adenomatous polyposis coli, beta-catenin.	Quercetin	0-9	catenin beta 1	Rattus norvegicus	197-209
33350534-3	2021	Our study was designed to investigate the effect of quercetin on DMH-mediated colon cancer by targeting adenomatous polyposis coli (APC) and beta-catenin in Wistar rats.	Quercetin	52-61	APC regulator of WNT signaling pathway	Rattus norvegicus	104-130
33350534-3	2021	Our study was designed to investigate the effect of quercetin on DMH-mediated colon cancer by targeting adenomatous polyposis coli (APC) and beta-catenin in Wistar rats.	Quercetin	52-61	catenin beta 1	Rattus norvegicus	141-153
33824873-12	2021	And molecular docking results showed that Quercetin combined well with MAPK3, IL-6, and TP53.	Quercetin	42-51	mitogen activated protein kinase 3	Rattus norvegicus	71-76
33824873-12	2021	And molecular docking results showed that Quercetin combined well with MAPK3, IL-6, and TP53.	Quercetin	42-51	interleukin 6	Rattus norvegicus	78-82
33667291-4	2021	Furthermore, quercetin significantly increased serum adiponectin (AdipoQ) concentration, and the expression levels of AdipoQ and AdipoR1.	Quercetin	13-22	adiponectin receptor 1	Mus musculus	129-136
33667291-5	2021	However, inhibition of adiponectin signaling by AdipoR1 siRNA significantly attenuated the effects of quercetin on muscle fiber type-related gene expression, the percentages of slow MyHC-positive and fast MyHC-positive fibers, and metabolic enzyme activity in C2C12 myotubes.	Quercetin	102-111	adiponectin, C1Q and collagen domain containing	Mus musculus	23-34
33625428-5	2021	Different spectroscopic measurements demonstrated that trilobatin could change the microenvironments and conformation of tyrosinase and molecular docking determined the binding site of quercetin on tyrosinase.	Quercetin	185-194	tyrosinase	Homo sapiens	198-208
33667291-5	2021	However, inhibition of adiponectin signaling by AdipoR1 siRNA significantly attenuated the effects of quercetin on muscle fiber type-related gene expression, the percentages of slow MyHC-positive and fast MyHC-positive fibers, and metabolic enzyme activity in C2C12 myotubes.	Quercetin	102-111	adiponectin receptor 1	Mus musculus	48-55
33667291-6	2021	Together, our data indicated that quercetin could promote skeletal fiber switching from glycolytic type II to oxidative type I through AdipoQ signaling.	Quercetin	34-43	adiponectin, C1Q and collagen domain containing	Mus musculus	135-141
33824873-12	2021	And molecular docking results showed that Quercetin combined well with MAPK3, IL-6, and TP53.	Quercetin	42-51	tumor protein p53	Rattus norvegicus	88-92
33824873-13	2021	An in vitro experiment indicated that XCHD and Quercetin inhibited the IL-6, TNF-alpha, and IL-1beta levels and MAPK3 and TP53.	Quercetin	47-56	interleukin 6	Rattus norvegicus	71-75
33733926-3	2021	Additionally, GLUT4, AKT2 and AMPK were docked with catechin, epicatechin, kaempferol, metformin, quercetin and ursolic acid reportedly present in Potentilla fulgens.	Quercetin	98-107	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	14-19
33824873-13	2021	An in vitro experiment indicated that XCHD and Quercetin inhibited the IL-6, TNF-alpha, and IL-1beta levels and MAPK3 and TP53.	Quercetin	47-56	tumor necrosis factor	Rattus norvegicus	77-86
33824873-13	2021	An in vitro experiment indicated that XCHD and Quercetin inhibited the IL-6, TNF-alpha, and IL-1beta levels and MAPK3 and TP53.	Quercetin	47-56	interleukin 1 alpha	Rattus norvegicus	92-100
33824873-13	2021	An in vitro experiment indicated that XCHD and Quercetin inhibited the IL-6, TNF-alpha, and IL-1beta levels and MAPK3 and TP53.	Quercetin	47-56	mitogen activated protein kinase 3	Rattus norvegicus	112-117
33824873-13	2021	An in vitro experiment indicated that XCHD and Quercetin inhibited the IL-6, TNF-alpha, and IL-1beta levels and MAPK3 and TP53.	Quercetin	47-56	tumor protein p53	Rattus norvegicus	122-126
33824873-14	2021	Conclusion: This study illustrated that XCHD and Quercetin contained in XD played an important role in the treatment of acute pancreatitis by acting on the key genes of MPAK3, IL-6, and TP53 which were associated with inflammation and apoptosis.	Quercetin	49-58	interleukin 6	Rattus norvegicus	176-180
33824873-14	2021	Conclusion: This study illustrated that XCHD and Quercetin contained in XD played an important role in the treatment of acute pancreatitis by acting on the key genes of MPAK3, IL-6, and TP53 which were associated with inflammation and apoptosis.	Quercetin	49-58	tumor protein p53	Rattus norvegicus	186-190
33464047-0	2021	Generation of a Bovine Serum Albumin-Diligand Complex for the Protection of Bioactive Quercetin and Suppression of Heme Toxicity.	Quercetin	86-95	albumin	Homo sapiens	23-36
33733575-0	2021	Quercetin prevents cadmium chloride-induced hepatic steatosis and fibrosis by downregulating the transcription of miR-21.	Quercetin	0-9	microRNA 21	Rattus norvegicus	114-120
33733575-1	2021	This study investigated if cadmium chloride (CdCl2 )-induced hepatic steatosis and fibrosis and the protective effect of quercetin (QUR) are mediated modulating the activity of miR-21, a known hepatic lipogenic and fibrotic miRNA.	Quercetin	121-130	microRNA 21	Rattus norvegicus	177-183
33347603-0	2021	Quercetin Induces p53-independent Cancer Cell Death via TFEB-mediated Lysosome Activation and ROS-dependent Ferroptosis.	Quercetin	0-9	tumor protein p53	Homo sapiens	18-21
33715179-8	2021	Eventually, the established method has been applied to screen potential alpha-glucosidase inhibitors from an extract of Lycium barbarum and the peak area of rutin, taxifolin, quercetin and chlorogenic acid in L. barbarum samples changed before and after the enzymatic reaction, confirming that these four compounds had potential inhibitory activities, which was consistent with the literature data.	Quercetin	175-184	sucrase-isomaltase	Homo sapiens	72-89
33737832-9	2021	The combination of quercetin and sitagliptin was more effective than each treatment alone in restoring the level of troponin, LDH, CKP, CRP, Cholesterol, LDL, TG, atherogenic index of plasma and significantly increased TAOC compared to DOX treated group.	Quercetin	19-28	C-reactive protein	Rattus norvegicus	136-139
33748166-0	2021	Quercetin Antagonizes Glucose Fluctuation Induced Renal Injury by Inhibiting Aerobic Glycolysis via HIF-1alpha/miR-210/ISCU/FeS Pathway.	Quercetin	0-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	100-110
33748166-0	2021	Quercetin Antagonizes Glucose Fluctuation Induced Renal Injury by Inhibiting Aerobic Glycolysis via HIF-1alpha/miR-210/ISCU/FeS Pathway.	Quercetin	0-9	microRNA 210	Mus musculus	111-118
33748166-0	2021	Quercetin Antagonizes Glucose Fluctuation Induced Renal Injury by Inhibiting Aerobic Glycolysis via HIF-1alpha/miR-210/ISCU/FeS Pathway.	Quercetin	0-9	iron-sulfur cluster assembly enzyme	Mus musculus	119-123
33748166-6	2021	This study aims to evaluate levels of aerobic glycolysis and repressive effect of quercetin via HIF-1alpha/miR210/ISCU/FeS axis in a cell model of GF.	Quercetin	82-91	hypoxia inducible factor 1, alpha subunit	Mus musculus	96-106
33748166-6	2021	This study aims to evaluate levels of aerobic glycolysis and repressive effect of quercetin via HIF-1alpha/miR210/ISCU/FeS axis in a cell model of GF.	Quercetin	82-91	microRNA 210	Mus musculus	107-113
33748166-6	2021	This study aims to evaluate levels of aerobic glycolysis and repressive effect of quercetin via HIF-1alpha/miR210/ISCU/FeS axis in a cell model of GF.	Quercetin	82-91	iron-sulfur cluster assembly enzyme	Mus musculus	114-118
33748166-15	2021	The mRNA expression and protein contents of HIF-1alpha were increased after GF exposure, and these could be alleviated by quercetin treatment.	Quercetin	122-131	hypoxia inducible factor 1, alpha subunit	Mus musculus	44-54
33748166-16	2021	Knockdown of ISCU by siRNA and Up-regulating of miR-210 by mimic could weaken the effects of quercetin that maintained protein levels of ISCU1/2, improved cell viability, relieved inflammation injury, decreased apoptosis, and reduced aerobic glycolysis switch in MCs.	Quercetin	93-102	iron-sulfur cluster assembly enzyme	Mus musculus	13-17
33748166-16	2021	Knockdown of ISCU by siRNA and Up-regulating of miR-210 by mimic could weaken the effects of quercetin that maintained protein levels of ISCU1/2, improved cell viability, relieved inflammation injury, decreased apoptosis, and reduced aerobic glycolysis switch in MCs.	Quercetin	93-102	microRNA 210	Mus musculus	48-55
33748166-16	2021	Knockdown of ISCU by siRNA and Up-regulating of miR-210 by mimic could weaken the effects of quercetin that maintained protein levels of ISCU1/2, improved cell viability, relieved inflammation injury, decreased apoptosis, and reduced aerobic glycolysis switch in MCs.	Quercetin	93-102	iron-sulfur cluster assembly enzyme	Mus musculus	137-144
33748166-17	2021	Conclusion: Quercetin antagonizes GF-induced renal injury by suppressing aerobic glycolysis via HIF-1alpha/miR-210/ISCU/FeS pathway in MCs cell model.	Quercetin	12-21	hypoxia inducible factor 1, alpha subunit	Mus musculus	96-106
33748166-17	2021	Conclusion: Quercetin antagonizes GF-induced renal injury by suppressing aerobic glycolysis via HIF-1alpha/miR-210/ISCU/FeS pathway in MCs cell model.	Quercetin	12-21	microRNA 210	Mus musculus	107-114
33748166-17	2021	Conclusion: Quercetin antagonizes GF-induced renal injury by suppressing aerobic glycolysis via HIF-1alpha/miR-210/ISCU/FeS pathway in MCs cell model.	Quercetin	12-21	iron-sulfur cluster assembly enzyme	Mus musculus	115-119
33658276-6	2021	As a proof of principle, we performed a pilot screen with a small compound library of kinase inhibitors and identified quercetin as a PilB inhibitor in vitro Using Myxococcus xanthus as a model bacterium, we found quercetin to reduce its T4P-dependent motility and T4P assembly in vivo.	Quercetin	119-128	methionine sulfoxide reductase B2	Homo sapiens	134-138
33658276-6	2021	As a proof of principle, we performed a pilot screen with a small compound library of kinase inhibitors and identified quercetin as a PilB inhibitor in vitro Using Myxococcus xanthus as a model bacterium, we found quercetin to reduce its T4P-dependent motility and T4P assembly in vivo.	Quercetin	214-223	methionine sulfoxide reductase B2	Homo sapiens	134-138
33439051-0	2021	Quercetin ameliorates the hepatic apoptosis of fetal rats induced by in utero exposure to fenitrothion via the transcriptional regulation of paraoxonase-1 and apoptosis-related genes.	Quercetin	0-9	paraoxonase 1	Rattus norvegicus	141-154
33439051-7	2021	CONCLUSIONS: Dietary supplements with quercetin can be used to reduce the risk from organophosphorus exposure probably through paraoxonase-1 up-regulation and enhancement of the cellular antioxidant system.	Quercetin	38-47	paraoxonase 1	Rattus norvegicus	127-140
33686878-0	2021	Quercetin suppresses cell survival and invasion in oral squamous cell carcinoma via the miR-1254/CD36 cascade in vitro.	Quercetin	0-9	microRNA 1254-1	Homo sapiens	88-96
33686878-4	2021	RESULTS: Quercetin significantly suppressed the proliferation and invasion of CAL-27 cells in a dose-dependent manner, while up-regulating miR-1254 and down-regulating CD36.	Quercetin	9-18	microRNA 1254-1	Homo sapiens	139-147
33686878-5	2021	The overexpression of miR-1254 also considerably down-regulated CD36 and enhanced the ability of quercetin to inhibit CAL-27 cell survival and invasion.	Quercetin	97-106	microRNA 1254-1	Homo sapiens	22-30
33686878-6	2021	Conversely, the inhibition of miR-1254 significantly up-regulated CD36 and antagonized the inhibitory effects of quercetin.	Quercetin	113-122	microRNA 1254-1	Homo sapiens	30-38
33686878-7	2021	CONCLUSION: Our study suggests that quercetin might suppress the progression of OSCC by activating the miR-1254/CD36 signaling pathway, indicating its potential as a treatment against OSCC.	Quercetin	36-45	microRNA 1254-1	Homo sapiens	103-111
33746703-0	2021	Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1alpha Pathway in vivo and in vitro.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	110-114
33746703-0	2021	Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1alpha Pathway in vivo and in vitro.	Quercetin	0-9	PPARG coactivator 1 alpha	Rattus norvegicus	115-125
33746703-2	2021	The present study investigated the neuroprotective potential of quercetin, a natural AMPK activator.	Quercetin	64-73	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	85-89
33746703-8	2021	The expressions of myelin basic protein and myelin protein zero were also increased by quercetin.	Quercetin	87-96	myelin basic protein	Rattus norvegicus	19-39
33746703-11	2021	Quercetin treatment promoted the expressions of phosphorylated AMPK, PGC-1alpha, SIRT1, NRF1, and TFAM under hyperglycemic state in vivo and in vitro.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	63-67
33746703-11	2021	Quercetin treatment promoted the expressions of phosphorylated AMPK, PGC-1alpha, SIRT1, NRF1, and TFAM under hyperglycemic state in vivo and in vitro.	Quercetin	0-9	PPARG coactivator 1 alpha	Rattus norvegicus	69-79
33746703-11	2021	Quercetin treatment promoted the expressions of phosphorylated AMPK, PGC-1alpha, SIRT1, NRF1, and TFAM under hyperglycemic state in vivo and in vitro.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	81-86
33746703-11	2021	Quercetin treatment promoted the expressions of phosphorylated AMPK, PGC-1alpha, SIRT1, NRF1, and TFAM under hyperglycemic state in vivo and in vitro.	Quercetin	0-9	nuclear respiratory factor 1	Rattus norvegicus	88-92
33746703-11	2021	Quercetin treatment promoted the expressions of phosphorylated AMPK, PGC-1alpha, SIRT1, NRF1, and TFAM under hyperglycemic state in vivo and in vitro.	Quercetin	0-9	transcription factor A, mitochondrial	Rattus norvegicus	98-102
33746703-12	2021	This study revealed that the neuroprotective effect of quercetin was mainly related to mitochondrial protection by activation of the AMPK/PGC-1alpha pathway for the first time and proved quercetin as a potential therapeutic agent in the management of diabetic neuropathy.	Quercetin	55-64	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	133-137
33746703-12	2021	This study revealed that the neuroprotective effect of quercetin was mainly related to mitochondrial protection by activation of the AMPK/PGC-1alpha pathway for the first time and proved quercetin as a potential therapeutic agent in the management of diabetic neuropathy.	Quercetin	55-64	PPARG coactivator 1 alpha	Rattus norvegicus	138-148
33746703-12	2021	This study revealed that the neuroprotective effect of quercetin was mainly related to mitochondrial protection by activation of the AMPK/PGC-1alpha pathway for the first time and proved quercetin as a potential therapeutic agent in the management of diabetic neuropathy.	Quercetin	187-196	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	133-137
33746703-12	2021	This study revealed that the neuroprotective effect of quercetin was mainly related to mitochondrial protection by activation of the AMPK/PGC-1alpha pathway for the first time and proved quercetin as a potential therapeutic agent in the management of diabetic neuropathy.	Quercetin	187-196	PPARG coactivator 1 alpha	Rattus norvegicus	138-148
33849106-11	2021	The results of molecular docking further illustrated the roles that the compounds with quercetin and beta-sitosterol play in the treatment of CHD through their interference with AKT1 and MAPK1 target proteins.	Quercetin	87-96	AKT serine/threonine kinase 1	Homo sapiens	178-182
33849106-11	2021	The results of molecular docking further illustrated the roles that the compounds with quercetin and beta-sitosterol play in the treatment of CHD through their interference with AKT1 and MAPK1 target proteins.	Quercetin	87-96	mitogen-activated protein kinase 1	Homo sapiens	187-192
33347603-0	2021	Quercetin Induces p53-independent Cancer Cell Death via TFEB-mediated Lysosome Activation and ROS-dependent Ferroptosis.	Quercetin	0-9	transcription factor EB	Homo sapiens	56-60
33347603-5	2021	KEY RESULTS: Quercetin is able to promote p53-independent cell death in various cancer cell lines.	Quercetin	13-22	tumor protein p53	Homo sapiens	42-45
33347603-7	2021	In contrast, both lysosome inhibitors and TFEB knockdown can prevent Quercetin-induced cell death, suggesting the involvement of lysosome.	Quercetin	69-78	transcription factor EB	Homo sapiens	42-46
33347603-8	2021	Next, Quercetin is found to induce lysosomal activation sequentially through TFEB nuclear translocation and transcriptional activation of lysosomal genes.	Quercetin	6-15	transcription factor EB	Homo sapiens	77-81
33347603-12	2021	CONCLUSION AND IMPLICATIONS: In summary, our study demonstrates that Quercetin induces TFEB-mediated lysosome activation and then promotes ferritin degradation, which consequently leads to ferroptosis and Bid-involved apoptosis.	Quercetin	69-78	transcription factor EB	Homo sapiens	87-91
33347603-12	2021	CONCLUSION AND IMPLICATIONS: In summary, our study demonstrates that Quercetin induces TFEB-mediated lysosome activation and then promotes ferritin degradation, which consequently leads to ferroptosis and Bid-involved apoptosis.	Quercetin	69-78	BH3 interacting domain death agonist	Homo sapiens	205-208
31711686-0	2021	Corrigendum to "Effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in broiler chickens".	Quercetin	39-48	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	95-102
32131700-6	2021	Static quenching of fluorescence due to HGD-quercetin complex formation at ground state was confirmed by finding excited state life time of Trp residues.	Quercetin	44-53	homogentisate 1,2-dioxygenase	Homo sapiens	40-43
32131700-8	2021	Hydrogen bonding and/or van der Waals interactions were involved between HGD and quercetin.	Quercetin	81-90	homogentisate 1,2-dioxygenase	Homo sapiens	73-76
32141392-0	2021	A study on the effects of inhibition mechanism of curcumin, quercetin, and resveratrol on human glutathione reductase through in vitro and in silico approaches.	Quercetin	60-69	glutathione-disulfide reductase	Homo sapiens	96-117
33481349-7	2021	Co-treatment with quercetin reduces pyruvate concentrations compared to TNFalpha-only treated controls.	Quercetin	18-27	tumor necrosis factor	Homo sapiens	72-80
33034398-5	2021	Quercetin inhibits 3CLpro and PLpro with a docking binding energy corresponding to -6.25 and -4.62 kcal/mol, respectively.	Quercetin	0-9	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	30-35
33034398-7	2021	On the basis of the clinical COVID-19 manifestations, the multifaceted aspect of quercetin as both antiinflammatory and thrombin-inhibitory actions, should be taken into consideration.	Quercetin	81-90	coagulation factor II, thrombin	Homo sapiens	120-128
33141412-7	2021	Surprisingly, our results demonstrated that the treatment in which we applied the combination of quercetin and metformin significantly reversed these changes and had a pronounced effect on the endometrial implant size and gene expression levels of mTOR and autophagy markers in ectopic endometrium.	Quercetin	97-106	mechanistic target of rapamycin kinase	Homo sapiens	248-252
32131700-0	2021	Elucidation of molecular interactions between human gammaD-crystallin and quercetin, an inhibitor against tryptophan oxidation.	Quercetin	74-83	crystallin gamma D	Homo sapiens	52-69
33520683-8	2021	Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.	Quercetin	12-21	angiotensin converting enzyme 2	Homo sapiens	203-207
33520683-8	2021	Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.	Quercetin	12-21	helicase for meiosis 1	Homo sapiens	241-249
33520683-8	2021	Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.	Quercetin	12-21	angiotensin I converting enzyme	Homo sapiens	203-206
33522827-2	2021	To develop an efficacious and safe nanotherapy against inflammatory bowel diseases (IBD), we designed a novel pH/ROS dual-responsive prodrug micelle GC-B-Que as an inflammatory-targeted drug, which was comprised by active quercetin (Que) covalently linked to biocompatible glycol chitosan (GC) by aryl boronic ester as a responsive linker.	Quercetin	222-231	natriuretic peptide receptor 2	Mus musculus	149-153
33522827-2	2021	To develop an efficacious and safe nanotherapy against inflammatory bowel diseases (IBD), we designed a novel pH/ROS dual-responsive prodrug micelle GC-B-Que as an inflammatory-targeted drug, which was comprised by active quercetin (Que) covalently linked to biocompatible glycol chitosan (GC) by aryl boronic ester as a responsive linker.	Quercetin	154-157	natriuretic peptide receptor 2	Mus musculus	149-153
33522827-7	2021	Further in vivo activities and biodistribution experiments found that the GC-B-Que micelles tended to accumulate in intestinal inflammation sites and showed better therapeutic efficacy than the free drugs (quercetin and mesalazine) in a colitis mice model.	Quercetin	206-215	natriuretic peptide receptor 2	Mus musculus	74-78
33242601-0	2021	Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-kappaB axis.	Quercetin	16-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-83
33285592-5	2021	Quercetin derivatives 5, 11,: and 13: with a hydroxyl group at C-4" inhibited the production of IL-2, GM-CSF, and TNF-alpha.	Quercetin	0-9	interleukin 2	Homo sapiens	96-100
33285592-5	2021	Quercetin derivatives 5, 11,: and 13: with a hydroxyl group at C-4" inhibited the production of IL-2, GM-CSF, and TNF-alpha.	Quercetin	0-9	colony stimulating factor 2	Homo sapiens	102-108
33285592-5	2021	Quercetin derivatives 5, 11,: and 13: with a hydroxyl group at C-4" inhibited the production of IL-2, GM-CSF, and TNF-alpha.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	114-123
33680916-9	2020	Furthermore, combining these results with those of cell viability assays, we proposed that ZINC000085537017 and quercetin were potential drugs for COL1A1 based on virtual screening and the TCMSP database, respectively.	Quercetin	112-121	collagen type I alpha 1 chain	Homo sapiens	147-153
33785094-0	2021	Quercetin Nanoparticle Ameliorates Lipopolysaccharide-Triggered Renal Inflammatory Impairment by Regulation of Sirt1/NF-KB Pathway.	Quercetin	0-9	sirtuin 1	Mus musculus	111-116
33668818-0	2021	Indol-3-Carbinol and Quercetin Ameliorate Chronic DSS-Induced Colitis in C57BL/6 Mice by AhR-Mediated Anti-Inflammatory Mechanisms.	Quercetin	21-30	aryl-hydrocarbon receptor	Mus musculus	89-92
33785094-9	2021	Moreover, the results from mice model and cell model showed that quercetin could diminish IkappaBalpha and p65 phosphorylation after LPS treatment.	Quercetin	65-74	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	90-102
33785094-9	2021	Moreover, the results from mice model and cell model showed that quercetin could diminish IkappaBalpha and p65 phosphorylation after LPS treatment.	Quercetin	65-74	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	107-110
33785094-10	2021	The most significant observation of this study was that quercetin elevated the expression of Sirt1.	Quercetin	56-65	sirtuin 1	Mus musculus	93-98
33785094-11	2021	Transfection of Sirt1 specific shRNA mitigated the suppression of quercetin on cell apoptosis, inflammation and of NF-kappaB activation triggered by LPS.	Quercetin	66-75	sirtuin 1	Mus musculus	16-21
33785094-11	2021	Transfection of Sirt1 specific shRNA mitigated the suppression of quercetin on cell apoptosis, inflammation and of NF-kappaB activation triggered by LPS.	Quercetin	66-75	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
33785094-12	2021	Therefore, these sequels indicate that quercetin protects against sepsis-associated AKI by upregulation Sirt1 expression through quenching NF-kappaB activation and may be an encouraging therapeutic agent for patients with sepsis-associated AKI.	Quercetin	39-48	sirtuin 1	Homo sapiens	104-109
33785094-12	2021	Therefore, these sequels indicate that quercetin protects against sepsis-associated AKI by upregulation Sirt1 expression through quenching NF-kappaB activation and may be an encouraging therapeutic agent for patients with sepsis-associated AKI.	Quercetin	39-48	nuclear factor kappa B subunit 1	Homo sapiens	139-148
33632310-0	2021	Quercetin attenuates the reduction of parvalbumin in middle cerebral artery occlusion animal model.	Quercetin	0-9	parvalbumin	Rattus norvegicus	38-49
33632310-5	2021	We investigated whether quercetin can regulate parvalbumin expression in cerebral ischemia and glutamate toxicity-induced neuronal cell death.	Quercetin	24-33	parvalbumin	Rattus norvegicus	47-58
33632310-9	2021	Moreover, quercetin prevented MCAO-induced a decrease in parvalbumin expression.	Quercetin	10-19	parvalbumin	Rattus norvegicus	57-68
33632310-10	2021	CONCLUSIONS: These findings suggest that quercetin exerts a neuroprotective effect through regulation of parvalbumin expression.	Quercetin	41-50	parvalbumin	Rattus norvegicus	105-116
33617360-0	2021	Quercetin Modulates Nrf2 and NF-kappaB/TLR-4 Pathways to Protect against Isoniazid and Rifampicin Induced Hepatotoxicity in vivo.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	20-24
33617360-0	2021	Quercetin Modulates Nrf2 and NF-kappaB/TLR-4 Pathways to Protect against Isoniazid and Rifampicin Induced Hepatotoxicity in vivo.	Quercetin	0-9	toll-like receptor 4	Rattus norvegicus	39-44
33617360-10	2021	Quercetin attenuated anti-TB drug induced oxidative stress by increasing NRF2 activation and expression, boosting endogenous antioxidant levels.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	73-77
33617360-11	2021	Additionally, quercetin blocked inflammatory mediators HMGB-1 and IFN-gamma, inhibiting activation of the NF-kappaB/TLR-4 axis.	Quercetin	14-23	high mobility group box 1	Rattus norvegicus	55-61
33617360-11	2021	Additionally, quercetin blocked inflammatory mediators HMGB-1 and IFN-gamma, inhibiting activation of the NF-kappaB/TLR-4 axis.	Quercetin	14-23	interferon gamma	Rattus norvegicus	66-75
33617360-11	2021	Additionally, quercetin blocked inflammatory mediators HMGB-1 and IFN-gamma, inhibiting activation of the NF-kappaB/TLR-4 axis.	Quercetin	14-23	toll-like receptor 4	Rattus norvegicus	116-121
33617360-12	2021	Quercetin protects against anti-TB liver injury by activating NRF2 and blocking NF-kappaB/TLR-4.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-66
33617360-12	2021	Quercetin protects against anti-TB liver injury by activating NRF2 and blocking NF-kappaB/TLR-4.	Quercetin	0-9	toll-like receptor 4	Rattus norvegicus	90-95
33681287-9	2020	We show that these variants are sensitive to known inhibitors phloretin and quercetin, demonstrating the potential of our expression systems to significantly accelerate the discovery of compounds that modulate the hexose transport activity of GLUT2 and GLUT3.	Quercetin	76-85	solute carrier family 2 member 2	Homo sapiens	243-248
33681287-9	2020	We show that these variants are sensitive to known inhibitors phloretin and quercetin, demonstrating the potential of our expression systems to significantly accelerate the discovery of compounds that modulate the hexose transport activity of GLUT2 and GLUT3.	Quercetin	76-85	solute carrier family 2 member 3	Homo sapiens	253-258
33628636-15	2021	In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC.	Quercetin	13-22	cyclin B1	Homo sapiens	92-97
33596716-4	2022	This review discusses reports of modulation of the Wnt/beta-Catenin signaling pathway by dietary polyphenols (resveratrol, avenanthramides, epigallocatechinin, curcumin, quercetin, silibinin, genistein and mangiferin) specifically focusing on CRC, and proposes a model as to how this modulation occurs.	Quercetin	170-179	catenin beta 1	Homo sapiens	55-67
33628636-15	2021	In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC.	Quercetin	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	81-84
33628636-15	2021	In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC.	Quercetin	13-22	cyclin dependent kinase 1	Homo sapiens	86-90
33628636-15	2021	In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC.	Quercetin	13-22	serpin family E member 1	Homo sapiens	99-107
33628636-15	2021	In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC.	Quercetin	13-22	checkpoint kinase 2	Homo sapiens	109-114
33628636-15	2021	In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC.	Quercetin	13-22	insulin like growth factor binding protein 3	Homo sapiens	120-126
33628636-15	2021	In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC.	Quercetin	13-22	tumor protein p53	Homo sapiens	135-138
33659046-9	2021	Quercetin treatment restore both, miR15a/16 and Bcl-2, to normal levels.	Quercetin	0-9	B cell leukemia/lymphoma 2	Mus musculus	48-53
33623367-14	2021	Quercetin might enhance the antitumor effect of cisplatin via inhibiting proliferation, migration and invasion and elevating apoptosis through weakening MMP2, ezrin, METTL3 and P-Gp expression of cancer cells.	Quercetin	0-9	matrix metallopeptidase 2	Homo sapiens	153-157
33659046-11	2021	However, after quercetin treatment, even radioresistant B-1 cells are not able to expand or disseminate in vivo, and the levels of miR15a/16 and Bcl-2 are also normalized.	Quercetin	15-24	B cell leukemia/lymphoma 2	Mus musculus	145-150
33623367-14	2021	Quercetin might enhance the antitumor effect of cisplatin via inhibiting proliferation, migration and invasion and elevating apoptosis through weakening MMP2, ezrin, METTL3 and P-Gp expression of cancer cells.	Quercetin	0-9	ezrin	Homo sapiens	159-164
33732149-0	2020	Corrigendum: Quercetin Induces Apoptosis Via Downregulation of VEGF/Akt Signaling Pathway in Acute Myeloid Leukemia Cells.	Quercetin	13-22	vascular endothelial growth factor A	Homo sapiens	63-67
33623367-14	2021	Quercetin might enhance the antitumor effect of cisplatin via inhibiting proliferation, migration and invasion and elevating apoptosis through weakening MMP2, ezrin, METTL3 and P-Gp expression of cancer cells.	Quercetin	0-9	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	166-172
33623367-14	2021	Quercetin might enhance the antitumor effect of cisplatin via inhibiting proliferation, migration and invasion and elevating apoptosis through weakening MMP2, ezrin, METTL3 and P-Gp expression of cancer cells.	Quercetin	0-9	phosphoglycolate phosphatase	Homo sapiens	177-181
33065239-0	2021	Quercetin regulates ERalpha mediated differentiation of BMSCs through circular RNA.	Quercetin	0-9	estrogen receptor 1	Homo sapiens	20-27
33345858-3	2021	Amongst these, Tamarixetin, a naturally occurring flavonoid derivative of Quercetin, demonstrated significant dose-dependent inhibition of MMP-9 expression.	Quercetin	74-83	matrix metallopeptidase 9	Homo sapiens	139-144
33732149-0	2020	Corrigendum: Quercetin Induces Apoptosis Via Downregulation of VEGF/Akt Signaling Pathway in Acute Myeloid Leukemia Cells.	Quercetin	13-22	AKT serine/threonine kinase 1	Homo sapiens	68-71
33017787-0	2021	Influence of antioxidant flavonoids quercetin and rutin on the in-vitro binding of neratinib to human serum albumin.	Quercetin	36-45	albumin	Homo sapiens	102-115
33017787-1	2021	This study was designed to examine the interaction of neratinib (NRB) with human serum albumin (HSA) in presence of flavonoids quercetin and rutin.	Quercetin	127-136	albumin	Homo sapiens	81-94
33017787-1	2021	This study was designed to examine the interaction of neratinib (NRB) with human serum albumin (HSA) in presence of flavonoids quercetin and rutin.	Quercetin	127-136	albumin	Homo sapiens	96-99
33017787-2	2021	Both quercetin and rutin can compete with NRB to bind to HSA and displace NRB from its binding site.	Quercetin	5-14	albumin	Homo sapiens	57-60
33557218-11	2021	Quercetin, a component of honey, can improve vasodilation by enhancing nitric oxide production via endothelial nitric oxide synthase and stimulate calcium-activated potassium channels.	Quercetin	0-9	nitric oxide synthase 3	Homo sapiens	99-132
33017787-7	2021	Interaction of NRB with HSA in presence of quercetin and rutin resulted in changes in the binding constants of HSA-NRB suggesting some impact on the binding of NRB in the presence of flavonoids.	Quercetin	43-52	albumin	Homo sapiens	24-27
33017787-7	2021	Interaction of NRB with HSA in presence of quercetin and rutin resulted in changes in the binding constants of HSA-NRB suggesting some impact on the binding of NRB in the presence of flavonoids.	Quercetin	43-52	albumin	Homo sapiens	111-114
33454441-8	2021	In addition, molecular docking revealed that both berberine and quercetin could bond with NOS2 and PPARalpha, respectively.	Quercetin	64-73	nitric oxide synthase 2	Homo sapiens	90-94
33457176-4	2021	Present study deals with in silico allosteric inhibition analysis of quercetin, against SARS-CoV-2-Mpro.	Quercetin	69-78	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	99-103
33457176-5	2021	Molecular docking of quercetin with Mpro revealed consistent binding of quercetin at a site other than active site in multiple runs, with the highest binding energy of - 8.31 kcal/mol, forming 6 H-bonds with residues Gln127, Cys128, Lys137, Asp289 and Glu290.	Quercetin	21-30	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	36-40
33457176-5	2021	Molecular docking of quercetin with Mpro revealed consistent binding of quercetin at a site other than active site in multiple runs, with the highest binding energy of - 8.31 kcal/mol, forming 6 H-bonds with residues Gln127, Cys128, Lys137, Asp289 and Glu290.	Quercetin	72-81	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	36-40
33457176-6	2021	Molecular dynamic simulation of 50 ns revealed high stability of Mpro-quercetin complex with RMSD values ranging from 0.1 to 0.25 nm.	Quercetin	70-79	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	65-69
33457176-7	2021	Moreover, native-Mpro and Mpro-quercetin complex conformations extracted at different time points from simulation trajectories were subjected to active site-specific docking with modelled substrate peptide (AVLQSGFR) by ZDOCK server.	Quercetin	31-40	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	26-30
33457176-9	2021	While substrate peptide remained intact when docked with Mpro-quercetin complex, also the binding energy of peptide reduced from 785 to 86 from 1 to 50 ns as quercetin induced alterations in the active site cavity reducing its affinity for the substrate.	Quercetin	62-71	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	57-61
33457176-9	2021	While substrate peptide remained intact when docked with Mpro-quercetin complex, also the binding energy of peptide reduced from 785 to 86 from 1 to 50 ns as quercetin induced alterations in the active site cavity reducing its affinity for the substrate.	Quercetin	158-167	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	57-61
33457176-11	2021	Hence, quercetin displayed effective allosteric inhibition potential against SARS-CoV-2 Mpro, and can be developed into an efficient treatment for COVID-19.	Quercetin	7-16	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	88-92
33634119-0	2021	Effect of Quercetin on Lipids Metabolism Through Modulating the Gut Microbial and AMPK/PPAR Signaling Pathway in Broilers.	Quercetin	10-19	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	82-86
33634119-0	2021	Effect of Quercetin on Lipids Metabolism Through Modulating the Gut Microbial and AMPK/PPAR Signaling Pathway in Broilers.	Quercetin	10-19	peroxisome proliferator activated receptor alpha	Homo sapiens	87-91
33634119-4	2021	In conclusion, quercetin improved lipid metabolism by modulating gut microbial and AMPK/PPAR signaling pathway in broilers.	Quercetin	15-24	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	83-87
33634119-4	2021	In conclusion, quercetin improved lipid metabolism by modulating gut microbial and AMPK/PPAR signaling pathway in broilers.	Quercetin	15-24	peroxisome proliferator activated receptor alpha	Homo sapiens	88-92
33623529-14	2021	The docking results indicated the strong binding activity between quercetin and AKT1.	Quercetin	66-75	AKT serine/threonine kinase 1	Homo sapiens	80-84
33564233-14	2021	Results: Quercetin significantly activated the JAK2/STAT3 pathway in vivo and in vitro, and MSNs intensified the activation.	Quercetin	9-18	Janus kinase 2	Rattus norvegicus	47-51
33564233-14	2021	Results: Quercetin significantly activated the JAK2/STAT3 pathway in vivo and in vitro, and MSNs intensified the activation.	Quercetin	9-18	signal transducer and activator of transcription 3	Rattus norvegicus	52-57
33564233-16	2021	Conclusion: Q-MSNs can significantly enhance the activation effect of quercetin on JAK2/STAT3 pathway, thus enhancing its protection on the heart of MIRI rats.	Quercetin	70-79	Janus kinase 2	Rattus norvegicus	83-87
33564233-16	2021	Conclusion: Q-MSNs can significantly enhance the activation effect of quercetin on JAK2/STAT3 pathway, thus enhancing its protection on the heart of MIRI rats.	Quercetin	70-79	signal transducer and activator of transcription 3	Rattus norvegicus	88-93
33359405-8	2021	Molecular docking indicated that cyanidin-3-glucoside (-9.2 kcal/mol) and quercetin (-9.6 kcal/mol) had the highest affinities for the Nrf2 binding site in the Keap1 protein, suggesting a possible competition with this transcription factor.	Quercetin	74-83	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
33359405-8	2021	Molecular docking indicated that cyanidin-3-glucoside (-9.2 kcal/mol) and quercetin (-9.6 kcal/mol) had the highest affinities for the Nrf2 binding site in the Keap1 protein, suggesting a possible competition with this transcription factor.	Quercetin	74-83	kelch like ECH associated protein 1	Homo sapiens	160-165
33454441-8	2021	In addition, molecular docking revealed that both berberine and quercetin could bond with NOS2 and PPARalpha, respectively.	Quercetin	64-73	peroxisome proliferator activated receptor alpha	Homo sapiens	99-108
33130188-6	2021	Quercetin supplementation increased genes and proteins in beta3-adrenergic receptor (ADRB3), p38 mitogen-activated protein kinase (MAPK), and AMP-activated protein kinase (AMPK) pathways in HFD-fed mice, which were suppressed by an AMPK inhibitor or an ADRB3 antagonist.	Quercetin	0-9	adrenergic receptor, beta 3	Mus musculus	85-90
33130188-6	2021	Quercetin supplementation increased genes and proteins in beta3-adrenergic receptor (ADRB3), p38 mitogen-activated protein kinase (MAPK), and AMP-activated protein kinase (AMPK) pathways in HFD-fed mice, which were suppressed by an AMPK inhibitor or an ADRB3 antagonist.	Quercetin	0-9	adrenergic receptor, beta 3	Mus musculus	253-258
33130188-6	2021	Quercetin supplementation increased genes and proteins in beta3-adrenergic receptor (ADRB3), p38 mitogen-activated protein kinase (MAPK), and AMP-activated protein kinase (AMPK) pathways in HFD-fed mice, which were suppressed by an AMPK inhibitor or an ADRB3 antagonist.	Quercetin	0-9	adrenergic receptor, beta 3	Mus musculus	58-83
32725694-0	2021	Effect of quercetin on the amiloride-bovine serum albumin interaction using spectroscopic methods, molecular docking and chemometric approaches.	Quercetin	10-19	albumin	Homo sapiens	44-57
33280258-7	2021	Capsaicin and quercetin alone and combination with gemcitabine decreased the expression of ABCC2 and DCK and TKs, in T24-GCB cells.	Quercetin	14-23	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	91-96
33280258-7	2021	Capsaicin and quercetin alone and combination with gemcitabine decreased the expression of ABCC2 and DCK and TKs, in T24-GCB cells.	Quercetin	14-23	deoxycytidine kinase	Mus musculus	101-104
32725694-1	2021	The effect of quercetin flavonoid (QUE), on the binding interaction of antihypertensive drug, amiloride (AMI) with bovine serum albumin (BSA) was investigated in this work.	Quercetin	35-38	albumin	Homo sapiens	122-135
33246157-0	2021	Quercetin exerts antidepressant and cardioprotective effects in estrogen receptor alpha-deficient female mice via BDNF-AKT/ERK1/2 signaling.	Quercetin	0-9	estrogen receptor 1 (alpha)	Mus musculus	64-87
33246157-0	2021	Quercetin exerts antidepressant and cardioprotective effects in estrogen receptor alpha-deficient female mice via BDNF-AKT/ERK1/2 signaling.	Quercetin	0-9	brain derived neurotrophic factor	Mus musculus	114-118
33246157-0	2021	Quercetin exerts antidepressant and cardioprotective effects in estrogen receptor alpha-deficient female mice via BDNF-AKT/ERK1/2 signaling.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	119-122
33246157-0	2021	Quercetin exerts antidepressant and cardioprotective effects in estrogen receptor alpha-deficient female mice via BDNF-AKT/ERK1/2 signaling.	Quercetin	0-9	mitogen-activated protein kinase 3	Mus musculus	123-129
33246157-4	2021	These findings suggested that ERalpha might be involved in the regulation of BDNF activity, thereby regulating depression-like and cardiovascular responses in female mice, and QUE exerted significant antidepressant and cardioprotective effects, at least in part, through BDNF-TrkB-AKT/ERK1/2 to effectively inhibit ERalpha-/--induced hippocampal and cardiac dysfunction.	Quercetin	176-179	brain derived neurotrophic factor	Mus musculus	271-275
33246157-4	2021	These findings suggested that ERalpha might be involved in the regulation of BDNF activity, thereby regulating depression-like and cardiovascular responses in female mice, and QUE exerted significant antidepressant and cardioprotective effects, at least in part, through BDNF-TrkB-AKT/ERK1/2 to effectively inhibit ERalpha-/--induced hippocampal and cardiac dysfunction.	Quercetin	176-179	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	276-280
33246157-4	2021	These findings suggested that ERalpha might be involved in the regulation of BDNF activity, thereby regulating depression-like and cardiovascular responses in female mice, and QUE exerted significant antidepressant and cardioprotective effects, at least in part, through BDNF-TrkB-AKT/ERK1/2 to effectively inhibit ERalpha-/--induced hippocampal and cardiac dysfunction.	Quercetin	176-179	thymoma viral proto-oncogene 1	Mus musculus	281-284
33246157-4	2021	These findings suggested that ERalpha might be involved in the regulation of BDNF activity, thereby regulating depression-like and cardiovascular responses in female mice, and QUE exerted significant antidepressant and cardioprotective effects, at least in part, through BDNF-TrkB-AKT/ERK1/2 to effectively inhibit ERalpha-/--induced hippocampal and cardiac dysfunction.	Quercetin	176-179	mitogen-activated protein kinase 3	Mus musculus	285-291
33246157-4	2021	These findings suggested that ERalpha might be involved in the regulation of BDNF activity, thereby regulating depression-like and cardiovascular responses in female mice, and QUE exerted significant antidepressant and cardioprotective effects, at least in part, through BDNF-TrkB-AKT/ERK1/2 to effectively inhibit ERalpha-/--induced hippocampal and cardiac dysfunction.	Quercetin	176-179	estrogen receptor 1 (alpha)	Mus musculus	315-322
32920133-13	2021	We found that Nrf2 promotes a cell antioxidant response and is a key common target in the response to treatment with isoliquiritigenin (ISL), pterostilbene (PTE) and quercetin (QUE), the highly absorbed active ingredients in the formula.	Quercetin	166-175	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
33278444-9	2021	Moreover, quercetin-glycyrrhizin nanogels were more effective in down-regulating the inflammation-related gene expression of tumor necrosis factor-alpha, interleukin-6, inducible nitric oxide synthase and monocyte chemotactic protein-1.	Quercetin	10-19	tumor necrosis factor	Homo sapiens	125-152
33278444-9	2021	Moreover, quercetin-glycyrrhizin nanogels were more effective in down-regulating the inflammation-related gene expression of tumor necrosis factor-alpha, interleukin-6, inducible nitric oxide synthase and monocyte chemotactic protein-1.	Quercetin	10-19	interleukin 6	Homo sapiens	154-167
33278444-9	2021	Moreover, quercetin-glycyrrhizin nanogels were more effective in down-regulating the inflammation-related gene expression of tumor necrosis factor-alpha, interleukin-6, inducible nitric oxide synthase and monocyte chemotactic protein-1.	Quercetin	10-19	C-C motif chemokine ligand 2	Homo sapiens	205-235
32920133-13	2021	We found that Nrf2 promotes a cell antioxidant response and is a key common target in the response to treatment with isoliquiritigenin (ISL), pterostilbene (PTE) and quercetin (QUE), the highly absorbed active ingredients in the formula.	Quercetin	177-180	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
33530513-0	2021	Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	52-95
33573178-6	2021	Although RSV and Q increased pgc1alpha expression, they did not significantly change either glucose oxidation or beta-oxidation.	Quercetin	17-18	PPARG coactivator 1 alpha	Homo sapiens	29-38
33509217-8	2021	Quercetin suppresses the NLRP3 inflammasome by affecting these regulators.	Quercetin	0-9	NLR family pyrin domain containing 3	Homo sapiens	25-30
33513822-0	2021	Caged Dexamethasone/Quercetin Nanoparticles, Formed of the Morphogenetic Active Inorganic Polyphosphate, are Strong Inducers of MUC5AC.	Quercetin	20-29	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	128-134
33146673-7	2021	RESULTS: The network pharmacology research showed that TCM could decrease IL-6 using several compounds, such as quercetin, ursolic acid, luteolin, and rutin.	Quercetin	112-121	interleukin 6	Homo sapiens	74-78
33146673-11	2021	Quercetin, ursolic acid, luteolin, and rutin could inhibit COVID-19 by downregulating IL-6.	Quercetin	0-9	interleukin 6	Homo sapiens	86-90
33514009-1	2021	In this study, the amino acid arginine (ARG) and P-glycoprotein (P-gp) inhibitors verapamil hydrochloride (VER), piperine (PIP) and quercetin (QRT) were used as co-formers for co-amorphous mixtures of a Biopharmaceutics classification system (BCS) class IV drug, furosemide (FUR).	Quercetin	132-141	ATP binding cassette subfamily B member 1	Homo sapiens	49-63
33514009-1	2021	In this study, the amino acid arginine (ARG) and P-glycoprotein (P-gp) inhibitors verapamil hydrochloride (VER), piperine (PIP) and quercetin (QRT) were used as co-formers for co-amorphous mixtures of a Biopharmaceutics classification system (BCS) class IV drug, furosemide (FUR).	Quercetin	132-141	ATP binding cassette subfamily B member 1	Homo sapiens	65-69
33530513-5	2021	Further study indicated that the protective effect of quercetin was associated with elevated protein abundance of nuclear factor erythroid 2-related factor 2 (Nrf2) and increased intracellular glutathione (GSH) content.	Quercetin	54-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-157
33530513-5	2021	Further study indicated that the protective effect of quercetin was associated with elevated protein abundance of nuclear factor erythroid 2-related factor 2 (Nrf2) and increased intracellular glutathione (GSH) content.	Quercetin	54-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	159-163
33530513-6	2021	Interestingly, the beneficial effects of quercetin on diquat-induced oxidative damage were abolished by all-trans-retinoic acid (Atra), a specific inhibitor of Nrf2, indicating a Nrf2-dependent regulation manner.	Quercetin	41-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	160-164
33530513-6	2021	Interestingly, the beneficial effects of quercetin on diquat-induced oxidative damage were abolished by all-trans-retinoic acid (Atra), a specific inhibitor of Nrf2, indicating a Nrf2-dependent regulation manner.	Quercetin	41-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	179-183
33530513-7	2021	The results show that quercetin attenuates diquat-induced cell injury by promoting protein abundance of Nrf2 and regulating GSH-related redox homeostasis in enterocytes.	Quercetin	22-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
33469482-0	2021	Effects of quercetin on diabetic retinopathy and its association with NLRP3 inflammasome and autophagy.	Quercetin	11-20	NLR family pyrin domain containing 3	Homo sapiens	70-75
33338087-0	2021	Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	66-71
33338087-5	2021	It indicated that the intervention of quercetin could increase the expression of sirtuin1 and prevent neuroinflammation, which was evident from the decrease in the protein levels of the astrocyte marker (GFAP) and inflammatory factors (cleaved-caspase 1, IL-1beta and IL-18).	Quercetin	38-47	sirtuin 1	Mus musculus	81-89
33338087-5	2021	It indicated that the intervention of quercetin could increase the expression of sirtuin1 and prevent neuroinflammation, which was evident from the decrease in the protein levels of the astrocyte marker (GFAP) and inflammatory factors (cleaved-caspase 1, IL-1beta and IL-18).	Quercetin	38-47	glial fibrillary acidic protein	Mus musculus	204-208
33338087-5	2021	It indicated that the intervention of quercetin could increase the expression of sirtuin1 and prevent neuroinflammation, which was evident from the decrease in the protein levels of the astrocyte marker (GFAP) and inflammatory factors (cleaved-caspase 1, IL-1beta and IL-18).	Quercetin	38-47	interleukin 1 alpha	Mus musculus	255-263
33338087-5	2021	It indicated that the intervention of quercetin could increase the expression of sirtuin1 and prevent neuroinflammation, which was evident from the decrease in the protein levels of the astrocyte marker (GFAP) and inflammatory factors (cleaved-caspase 1, IL-1beta and IL-18).	Quercetin	38-47	interleukin 18	Mus musculus	268-273
33338087-7	2021	Current data indicated that quercetin might improve neuroinflammation in aging mice by regulating the Sirtuin1/NLRP3 pathway.	Quercetin	28-37	sirtuin 1	Mus musculus	102-110
33338087-7	2021	Current data indicated that quercetin might improve neuroinflammation in aging mice by regulating the Sirtuin1/NLRP3 pathway.	Quercetin	28-37	NLR family, pyrin domain containing 3	Mus musculus	111-116
33469482-1	2021	AIM: To investigate the effects of quercetin on diabetic retinopathy (DR) and its association with nucleotide-binding oligomerization domain-like receptors 3 (NLRP3) inflammasome and autophagy using retinal endothelial cell as an experimental model.	Quercetin	35-44	NLR family pyrin domain containing 3	Homo sapiens	159-164
33469482-7	2021	Quercetin inhibited angiogenesis of HRMECs as well as the expressions of NLRP3, ASC, Caspase-1, IL-1beta, IL-18, LC3, Beclin-1, and autophagy of HRMECs under a HG condition.	Quercetin	0-9	NLR family pyrin domain containing 3	Homo sapiens	73-78
33469482-7	2021	Quercetin inhibited angiogenesis of HRMECs as well as the expressions of NLRP3, ASC, Caspase-1, IL-1beta, IL-18, LC3, Beclin-1, and autophagy of HRMECs under a HG condition.	Quercetin	0-9	PYD and CARD domain containing	Homo sapiens	80-83
33469482-7	2021	Quercetin inhibited angiogenesis of HRMECs as well as the expressions of NLRP3, ASC, Caspase-1, IL-1beta, IL-18, LC3, Beclin-1, and autophagy of HRMECs under a HG condition.	Quercetin	0-9	caspase 1	Homo sapiens	85-94
33469482-7	2021	Quercetin inhibited angiogenesis of HRMECs as well as the expressions of NLRP3, ASC, Caspase-1, IL-1beta, IL-18, LC3, Beclin-1, and autophagy of HRMECs under a HG condition.	Quercetin	0-9	interleukin 1 alpha	Homo sapiens	96-104
33469482-7	2021	Quercetin inhibited angiogenesis of HRMECs as well as the expressions of NLRP3, ASC, Caspase-1, IL-1beta, IL-18, LC3, Beclin-1, and autophagy of HRMECs under a HG condition.	Quercetin	0-9	interleukin 18	Homo sapiens	106-111
33469482-7	2021	Quercetin inhibited angiogenesis of HRMECs as well as the expressions of NLRP3, ASC, Caspase-1, IL-1beta, IL-18, LC3, Beclin-1, and autophagy of HRMECs under a HG condition.	Quercetin	0-9	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	113-116
33469482-7	2021	Quercetin inhibited angiogenesis of HRMECs as well as the expressions of NLRP3, ASC, Caspase-1, IL-1beta, IL-18, LC3, Beclin-1, and autophagy of HRMECs under a HG condition.	Quercetin	0-9	beclin 1	Homo sapiens	118-126
33469482-8	2021	The inhibitory effects of quercetin on angiogenesis, NLRP3 inflammasome and autophagy increased with the increase of its concentration.	Quercetin	26-35	NLR family pyrin domain containing 3	Homo sapiens	53-58
33395297-0	2021	Quercetin Attenuated Myeloperoxidase-Dependent HOCl Generation and Endothelial Dysfunction in Diabetic Vasculature.	Quercetin	0-9	myeloperoxidase	Mus musculus	21-36
33396069-0	2021	Quercetin alleviates Cadmium-induced autophagy inhibition via TFEB-dependent lysosomal restoration in primary proximal tubular cells.	Quercetin	0-9	transcription factor EB	Rattus norvegicus	62-66
33444408-6	2021	Quercetin may also serve as SARS-CoV-2 inhibitor by binding with the active sites of SARS-CoV-2 main protease 3CL and ACE2, therefore suppressing the functions of the proteins to cut the viral life cycle.	Quercetin	0-9	angiotensin converting enzyme 2	Homo sapiens	118-122
33395297-3	2021	Herein, we investigated the therapeutic mechanism for quercetin on MPO-mediated HOCl generation and endothelial dysfunction in diabetic vasculature.	Quercetin	54-63	myeloperoxidase	Mus musculus	67-70
33395297-5	2021	Furthermore, quercetin effectively inhibited MPO/high glucose-mediated HOCl generation and cytotoxicity to vascular endothelial cells.	Quercetin	13-22	myeloperoxidase	Mus musculus	45-48
33395297-6	2021	The inhibitive effect on MPO activity was related to the fact that quercetin reduced high glucose-induced H2O2 generation in endothelial cells and directly acted as a competitive substrate for MPO, thus limiting MPO/H2O2-dependent HOCl production.	Quercetin	67-76	myeloperoxidase	Mus musculus	25-28
33395297-6	2021	The inhibitive effect on MPO activity was related to the fact that quercetin reduced high glucose-induced H2O2 generation in endothelial cells and directly acted as a competitive substrate for MPO, thus limiting MPO/H2O2-dependent HOCl production.	Quercetin	67-76	myeloperoxidase	Mus musculus	193-196
33395297-6	2021	The inhibitive effect on MPO activity was related to the fact that quercetin reduced high glucose-induced H2O2 generation in endothelial cells and directly acted as a competitive substrate for MPO, thus limiting MPO/H2O2-dependent HOCl production.	Quercetin	67-76	myeloperoxidase	Mus musculus	193-196
33395297-9	2021	Therefore, it was demonstrated herein that quercetin inhibited endothelial injury in diabetic vasculature via suppression of MPO/high glucose-dependent HOCl formation.	Quercetin	43-52	myeloperoxidase	Mus musculus	125-128
33437022-9	2021	Collectively, these results suggest that SWTX decreases I/R injury, and the PI3K/Akt/FoxO3a pathway takes part in protection during this process, gallogen (G3) and quercetin (G8) of GZ, methyleugenol (R2) and macelignan (R7) of RDK, santol (T1) of TX are responsible at least in part for SWTX"s cardioprotection effect.	Quercetin	164-173	forkhead box O3	Rattus norvegicus	85-91
33421256-0	2021	Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling pathway.	Quercetin	0-9	sirtuin 1	Mus musculus	140-145
33437022-8	2021	In vitro, blocking Akt and p-FoxO3a activation with the PI3K inhibitor LY294002 effectively suppressed the protective effects of several active monomers (including quercetin, macelignan,methyleugenol and Santol) of SWTX against H2O2-induced injury.	Quercetin	164-173	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
33421256-8	2021	Quercetin treatment (2 and 5 muM) induced significant upregulation of antioxidant enzymes, SOD1 and SOD2, in mBMSCs.	Quercetin	0-9	superoxide dismutase 1, soluble	Mus musculus	91-95
33421256-8	2021	Quercetin treatment (2 and 5 muM) induced significant upregulation of antioxidant enzymes, SOD1 and SOD2, in mBMSCs.	Quercetin	0-9	superoxide dismutase 2, mitochondrial	Mus musculus	100-104
33421256-10	2021	Quercetin treatment enhanced the phosphorylation of AMPK protein and upregulated the expression of SIRT1, thus activating the AMPK/SIRT1 signaling pathway in mBMSCs.	Quercetin	0-9	sirtuin 1	Mus musculus	99-104
33421256-10	2021	Quercetin treatment enhanced the phosphorylation of AMPK protein and upregulated the expression of SIRT1, thus activating the AMPK/SIRT1 signaling pathway in mBMSCs.	Quercetin	0-9	sirtuin 1	Mus musculus	131-136
33421256-11	2021	Quercetin promoted osteogenic differentiation and antioxidant responses of mBMSCs by activating the AMPK/SIRT1 signaling pathway.	Quercetin	0-9	sirtuin 1	Mus musculus	105-110
33397267-6	2021	RESULTS: Quercetin combined with vincristine showed an effect similar to verapamil (an ABCB1 inhibitor), and the docking showed that bind to ABCB1 in a similar region.	Quercetin	9-18	ATP binding cassette subfamily B member 1	Homo sapiens	141-146
33490128-7	2020	Quercetin supplementation also inhibited the activities of caspases-9 and-3, and the expression of p53 and Bax mRNAs.	Quercetin	0-9	caspase 9	Mus musculus	59-75
33490128-7	2020	Quercetin supplementation also inhibited the activities of caspases-9 and-3, and the expression of p53 and Bax mRNAs.	Quercetin	0-9	transformation related protein 53, pseudogene	Mus musculus	99-102
33490128-7	2020	Quercetin supplementation also inhibited the activities of caspases-9 and-3, and the expression of p53 and Bax mRNAs.	Quercetin	0-9	BCL2-associated X protein	Mus musculus	107-110
33490128-8	2020	Furthermore, quercetin supplementation markedly activated the expression of Nrf2 and HO-1 mRNAs, but inhibited the expression of NF-kappaB, IL-1beta, IL-6, and TNF-alpha mRNAs.	Quercetin	13-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-80
33490128-8	2020	Furthermore, quercetin supplementation markedly activated the expression of Nrf2 and HO-1 mRNAs, but inhibited the expression of NF-kappaB, IL-1beta, IL-6, and TNF-alpha mRNAs.	Quercetin	13-22	heme oxygenase 1	Mus musculus	85-89
33490128-8	2020	Furthermore, quercetin supplementation markedly activated the expression of Nrf2 and HO-1 mRNAs, but inhibited the expression of NF-kappaB, IL-1beta, IL-6, and TNF-alpha mRNAs.	Quercetin	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	129-138
33490128-8	2020	Furthermore, quercetin supplementation markedly activated the expression of Nrf2 and HO-1 mRNAs, but inhibited the expression of NF-kappaB, IL-1beta, IL-6, and TNF-alpha mRNAs.	Quercetin	13-22	interleukin 1 alpha	Mus musculus	140-148
33490128-8	2020	Furthermore, quercetin supplementation markedly activated the expression of Nrf2 and HO-1 mRNAs, but inhibited the expression of NF-kappaB, IL-1beta, IL-6, and TNF-alpha mRNAs.	Quercetin	13-22	interleukin 6	Mus musculus	150-154
33490128-8	2020	Furthermore, quercetin supplementation markedly activated the expression of Nrf2 and HO-1 mRNAs, but inhibited the expression of NF-kappaB, IL-1beta, IL-6, and TNF-alpha mRNAs.	Quercetin	13-22	tumor necrosis factor	Mus musculus	160-169
33490128-9	2020	In conclusion, our results revealed that quercetin supplementation could inhibit CuSO4-induced nephrotoxicity in mice via the inhibition of mitochondrial apoptotic and NF-kappaB pathways and the activation of Nrf2/HO-1 pathway.	Quercetin	41-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	168-177
33490128-9	2020	In conclusion, our results revealed that quercetin supplementation could inhibit CuSO4-induced nephrotoxicity in mice via the inhibition of mitochondrial apoptotic and NF-kappaB pathways and the activation of Nrf2/HO-1 pathway.	Quercetin	41-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	209-213
33490128-9	2020	In conclusion, our results revealed that quercetin supplementation could inhibit CuSO4-induced nephrotoxicity in mice via the inhibition of mitochondrial apoptotic and NF-kappaB pathways and the activation of Nrf2/HO-1 pathway.	Quercetin	41-50	heme oxygenase 1	Mus musculus	214-218
33395480-6	2021	The limits of detection for quercetin and luteolin range from 0.51 to 1.32 ng mL-1 in serum and from 0.23 to 1.05 ng mL-1 in urine, the recoveries are between 95.20 and 103.73% with the RSD less than 5.77%.	Quercetin	28-37	L1 cell adhesion molecule	Mus musculus	78-82
33397267-7	2021	The quercetin also was capable of to alter ABCB1 gene expression.	Quercetin	4-13	ATP binding cassette subfamily B member 1	Homo sapiens	43-48
33657989-0	2021	Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway.	Quercetin	0-9	AXL receptor tyrosine kinase	Homo sapiens	65-68
33657989-0	2021	Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway.	Quercetin	0-9	interleukin 6	Homo sapiens	69-73
33657989-0	2021	Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	74-79
33657989-5	2021	However, the effect of quercetin on Axl has never been reported.	Quercetin	23-32	AXL receptor tyrosine kinase	Homo sapiens	36-39
33657989-8	2021	Quercetin also decreased IL-6 release and phosphorylation of STAT3 in GBM cells.	Quercetin	0-9	interleukin 6	Homo sapiens	25-29
33657989-8	2021	Quercetin also decreased IL-6 release and phosphorylation of STAT3 in GBM cells.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	61-66
33657989-9	2021	In addition, gene expression, protein expression, and half-life of synthesized Axl protein were all suppressed by quercetin.	Quercetin	114-123	AXL receptor tyrosine kinase	Homo sapiens	79-82
33657989-10	2021	By applying shRNA for knockdown of Axl, we could confirm that the role of Axl was crucial in the apoptotic effect of quercetin on GBM cells.	Quercetin	117-126	AXL receptor tyrosine kinase	Homo sapiens	35-38
33657989-10	2021	By applying shRNA for knockdown of Axl, we could confirm that the role of Axl was crucial in the apoptotic effect of quercetin on GBM cells.	Quercetin	117-126	AXL receptor tyrosine kinase	Homo sapiens	74-77
33657989-11	2021	In conclusion, we suggest quercetin as a potential anticancer agent, which may improve cancer microenvironment of GBM via the Axl/IL-6/STAT3 pathway.	Quercetin	26-35	AXL receptor tyrosine kinase	Homo sapiens	126-129
33657989-11	2021	In conclusion, we suggest quercetin as a potential anticancer agent, which may improve cancer microenvironment of GBM via the Axl/IL-6/STAT3 pathway.	Quercetin	26-35	interleukin 6	Homo sapiens	130-134
33657989-11	2021	In conclusion, we suggest quercetin as a potential anticancer agent, which may improve cancer microenvironment of GBM via the Axl/IL-6/STAT3 pathway.	Quercetin	26-35	signal transducer and activator of transcription 3	Homo sapiens	135-140
32598250-10	2021	Meanwhile, for MurA and serine protease, compound 4 is the highest of bonding energy with values of -8.7 and -6.4 Kcal/mol before quercetin (MurA, -8.9 Kcal/mol) and taxifolin (serine protease, -6.6 Kcal/mol).	Quercetin	130-139	coagulation factor II, thrombin	Homo sapiens	24-39
33507682-9	2021	Quercetin-treatment decreased the sharp increase in RNA expression of BAX and MPO in both cisplatin-toxicated testes and after MNU carcinogenesis induction.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Rattus norvegicus	70-73
33507682-9	2021	Quercetin-treatment decreased the sharp increase in RNA expression of BAX and MPO in both cisplatin-toxicated testes and after MNU carcinogenesis induction.	Quercetin	0-9	myeloperoxidase	Rattus norvegicus	78-81
33507682-10	2021	In addition, the testicular levels of testosterone and SOD increased in parallel with depletion of MDA, IL-6, AFP and caspase-3 levels in MNU and/or cisplatin-treatment after -quercetin-treatment.	Quercetin	176-185	alpha-fetoprotein	Rattus norvegicus	110-113
33507682-10	2021	In addition, the testicular levels of testosterone and SOD increased in parallel with depletion of MDA, IL-6, AFP and caspase-3 levels in MNU and/or cisplatin-treatment after -quercetin-treatment.	Quercetin	176-185	caspase 3	Rattus norvegicus	118-127
32598250-10	2021	Meanwhile, for MurA and serine protease, compound 4 is the highest of bonding energy with values of -8.7 and -6.4 Kcal/mol before quercetin (MurA, -8.9 Kcal/mol) and taxifolin (serine protease, -6.6 Kcal/mol).	Quercetin	130-139	kallikrein related peptidase 7	Homo sapiens	177-196
33276066-0	2021	Pretreatment of IEC-6 cells with quercetin and myricetin resists the indomethacin-induced barrier dysfunction via attenuating the calcium-mediated JNK/Src activation.	Quercetin	33-42	mitogen-activated protein kinase 8	Rattus norvegicus	147-150
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Quercetin	75-84	angiotensin converting enzyme 2	Homo sapiens	197-202
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Quercetin	75-84	angiotensin converting enzyme 2	Homo sapiens	249-254
33276066-0	2021	Pretreatment of IEC-6 cells with quercetin and myricetin resists the indomethacin-induced barrier dysfunction via attenuating the calcium-mediated JNK/Src activation.	Quercetin	33-42	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	151-154
33091574-3	2021	METHODS: Inhibition of adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP) and xanthine oxidoreductase (XOR) activity by quercetin and metabolites was determined by HPLC.	Quercetin	134-143	purine nucleoside phosphorylase	Homo sapiens	50-81
33091574-3	2021	METHODS: Inhibition of adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP) and xanthine oxidoreductase (XOR) activity by quercetin and metabolites was determined by HPLC.	Quercetin	134-143	adenosine deaminase	Homo sapiens	23-42
33091574-3	2021	METHODS: Inhibition of adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP) and xanthine oxidoreductase (XOR) activity by quercetin and metabolites was determined by HPLC.	Quercetin	134-143	xanthine dehydrogenase	Homo sapiens	92-115
33091574-3	2021	METHODS: Inhibition of adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP) and xanthine oxidoreductase (XOR) activity by quercetin and metabolites was determined by HPLC.	Quercetin	134-143	adenosine deaminase	Homo sapiens	44-47
33091574-3	2021	METHODS: Inhibition of adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP) and xanthine oxidoreductase (XOR) activity by quercetin and metabolites was determined by HPLC.	Quercetin	134-143	xanthine dehydrogenase	Homo sapiens	117-120
33091574-5	2021	RESULTS: In human plasma, no inhibition of PNP activity was observed, and only quercetin weakly inhibited ADA.	Quercetin	79-88	adenosine deaminase	Homo sapiens	106-109
33091574-8	2021	CONCLUSIONS: We propose that the main mechanism by which quercetin, as quercetin-3"-sulfate, lowers uric acid in vivo is through inhibition of XOR, and not ADA nor PNP.	Quercetin	57-66	xanthine dehydrogenase	Bos taurus	143-146
33745380-7	2021	Pharmacological inhibition of PI3K or JNK, using thalidomide, quercetin, or SP600125, attenuated the development of morphine tolerance in mice with SNL as measured by thermal paw withdrawal.	Quercetin	62-71	mitogen-activated protein kinase 8	Mus musculus	38-41
32485264-12	2021	BLG facilitated quercetin-dependent AhR-activation and, downstream AhR, lung Cyp1A1 expression.	Quercetin	16-25	beta-lactoglobulin	Bos taurus	0-3
32485264-12	2021	BLG facilitated quercetin-dependent AhR-activation and, downstream AhR, lung Cyp1A1 expression.	Quercetin	16-25	aryl hydrocarbon receptor	Homo sapiens	36-39
33039581-0	2021	Diet-Induced Obesity in Genetically Diverse Collaborative Cross Mouse Founder Strains Reveals Diverse Phenotype Response and Amelioration by Quercetin Treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ and WSB/EiJ Mice.	Quercetin	141-150	calpastatin	Mus musculus	186-190
33039581-11	2021	For female mice, quercetin blunted weight gain (relative to the high-fat phase) in CAST/PhJ, PWK/EiJ and WSB/EiJ mice compared to C57.	Quercetin	17-26	calpastatin	Mus musculus	83-87
32757775-9	2021	Factor VIII expressions decreased in quercetin groups compared to control tumor tissue (p < 0.05).	Quercetin	37-46	coagulation factor VIII	Mus musculus	0-11
33759122-8	2021	Furthermore, herein is described the docking process of calf thymus DNA with three metal complexes, as a potential metallo-therapeutics as also the docking process of the plant flavonoid quercetin to the antiapoptotic protein BcL-xL.	Quercetin	187-196	BCL2 like 1	Bos taurus	226-232
32329631-3	2021	The aim of this study was to determine the effect of quercetin (Q) on triggering the programed death of human promyelocytic leukemia sensitive cells HL60 as well as multidrug resistant HL60/VINC cells overexpressing P-glycoprotein and HL60/MX2 cells characterized by the presence of mutated alpha isoform of topoisomerase II and the absence of beta isoform of this enzyme.	Quercetin	53-62	ATP binding cassette subfamily B member 1	Homo sapiens	216-230
33154094-9	2021	The molecular events associated with the protective effect of quercetin and myricetin were related to the elevated expression of photoreceptor-specific proteins, rhodopsin and cone opsins, decreased expression of the specific inflammatory markers, and the shift of the equilibrium between BAX/BCL-2 towards an anti-apoptotic profile.	Quercetin	62-71	rhodopsin	Mus musculus	162-171
33154094-9	2021	The molecular events associated with the protective effect of quercetin and myricetin were related to the elevated expression of photoreceptor-specific proteins, rhodopsin and cone opsins, decreased expression of the specific inflammatory markers, and the shift of the equilibrium between BAX/BCL-2 towards an anti-apoptotic profile.	Quercetin	62-71	BCL2-associated X protein	Mus musculus	289-292
33154094-9	2021	The molecular events associated with the protective effect of quercetin and myricetin were related to the elevated expression of photoreceptor-specific proteins, rhodopsin and cone opsins, decreased expression of the specific inflammatory markers, and the shift of the equilibrium between BAX/BCL-2 towards an anti-apoptotic profile.	Quercetin	62-71	B cell leukemia/lymphoma 2	Mus musculus	293-298
32329631-3	2021	The aim of this study was to determine the effect of quercetin (Q) on triggering the programed death of human promyelocytic leukemia sensitive cells HL60 as well as multidrug resistant HL60/VINC cells overexpressing P-glycoprotein and HL60/MX2 cells characterized by the presence of mutated alpha isoform of topoisomerase II and the absence of beta isoform of this enzyme.	Quercetin	64-65	ATP binding cassette subfamily B member 1	Homo sapiens	216-230
32329631-7	2021	The present study also indicated that Q used at IC90 triggers predominantly programed cell death of sensitive HL60 cells and their MDR counterparts by induction of apoptosis occurring with the involvement of caspase-3 and caspase-8 as well as by lysosome membrane permeabilization-dependent mechanisms.	Quercetin	38-39	caspase 3	Homo sapiens	208-217
32329631-7	2021	The present study also indicated that Q used at IC90 triggers predominantly programed cell death of sensitive HL60 cells and their MDR counterparts by induction of apoptosis occurring with the involvement of caspase-3 and caspase-8 as well as by lysosome membrane permeabilization-dependent mechanisms.	Quercetin	38-39	caspase 8	Homo sapiens	222-231
32420759-11	2021	Combination of quercetin and curcumin was effective on genes that were particularly related to p53, NF-kappaB and TGF-alpha pathways.	Quercetin	15-24	tumor protein p53	Homo sapiens	95-98
32420759-11	2021	Combination of quercetin and curcumin was effective on genes that were particularly related to p53, NF-kappaB and TGF-alpha pathways.	Quercetin	15-24	nuclear factor kappa B subunit 1	Homo sapiens	100-109
32420759-11	2021	Combination of quercetin and curcumin was effective on genes that were particularly related to p53, NF-kappaB and TGF-alpha pathways.	Quercetin	15-24	transforming growth factor alpha	Homo sapiens	114-123
33612499-0	2021	Protective effects of quercetin on traumatic brain injury induced inflammation and oxidative stress in cortex through activating Nrf2/HO-1 pathway.	Quercetin	22-31	NFE2 like bZIP transcription factor 2	Rattus norvegicus	129-133
33612499-0	2021	Protective effects of quercetin on traumatic brain injury induced inflammation and oxidative stress in cortex through activating Nrf2/HO-1 pathway.	Quercetin	22-31	heme oxygenase 1	Rattus norvegicus	134-138
33612499-17	2021	Quercetin treatment activated the cortical Nrf2/HO-1 pathway in TBI rats.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	43-47
33612499-17	2021	Quercetin treatment activated the cortical Nrf2/HO-1 pathway in TBI rats.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	48-52
33612499-18	2021	CONCLUSIONS: Quercetin ameliorated the TBI-induced neuroinflammation and oxidative stress in the cortex through activating the Nrf2/HO-1 pathway.	Quercetin	13-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	127-131
33612499-18	2021	CONCLUSIONS: Quercetin ameliorated the TBI-induced neuroinflammation and oxidative stress in the cortex through activating the Nrf2/HO-1 pathway.	Quercetin	13-22	heme oxygenase 1	Rattus norvegicus	132-136
33839683-7	2021	Instead, two tt7 mutant alleles, with defects in a branchpoint enzyme blocking quercetin biosynthesis, formed reduced numbers of lateral roots and tt7-2 had elevated levels of kaempferol.	Quercetin	79-88	Cytochrome P450 superfamily protein	Arabidopsis thaliana	13-16
33456481-12	2020	Quercetin was hypothesized to be the key bioactive ingredient in JDNW Formula and has a good binding affinity to AMPK based on molecular docking verification.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	113-117
33174591-0	2020	Paper Withdrawn: Quercetin attenuates high glucose-induced injury in human retinal pigment epithelial cell line ARPE-19 by up-regulation of miR-29b.	Quercetin	17-26	microRNA 29b-1	Homo sapiens	140-147
33008592-5	2020	Among all tested flavonoids, quercetin was the most potent inhibitor for HCN channels with an IC50 value of 27.32 +- 1.19 muM for HCN2.	Quercetin	29-38	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	130-134
33426081-6	2020	Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways.	Quercetin	84-93	AKT serine/threonine kinase 1	Homo sapiens	181-184
33426081-6	2020	Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways.	Quercetin	84-93	tumor necrosis factor	Homo sapiens	186-189
33426081-6	2020	Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways.	Quercetin	84-93	hypoxia inducible factor 1 subunit alpha	Homo sapiens	197-202
33426081-6	2020	Results: The active components of ZR-CR-shogaol, daucosterol, ginkgetin, berberine, quercetin, chlorogenic acid, and vanillic acid-exhibited antitumor activities via the MAPK, PI3K-AKT, TNF, FOXO, HIF-1, and VEGF signaling pathways.	Quercetin	84-93	vascular endothelial growth factor A	Homo sapiens	208-212
33426081-7	2020	Molecular docking and SPR analyses suggested direct binding of berberine with AKT1 and TP53; quercetin with EGFR and VEGF165; and ginkgetin, isoginkgetin, and daucosterol with VEGF165 with weak affinities.	Quercetin	93-102	epidermal growth factor receptor	Homo sapiens	108-112
33334302-7	2021	Quercetin can also demonstrate therapeutic effects via affecting molecular pathways such as NF- B, PI3K/Akt and so on.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	104-107
33334302-8	2021	METHODS: In the present review, we demonstrate that quercetin administration is beneficial in ameliorating I/R injury via reducing ROS levels, inhibition of inflammation, and affecting molecular pathways such as TLR4/NF- B, MAPK and so on.	Quercetin	52-61	toll like receptor 4	Homo sapiens	212-216
33334302-10	2021	Apoptotic cell death is inhibited by quercetin via down-regulation of Bax, and caspases, and upregulation of Bcl-2.	Quercetin	37-46	BCL2 associated X, apoptosis regulator	Homo sapiens	70-73
33334302-10	2021	Apoptotic cell death is inhibited by quercetin via down-regulation of Bax, and caspases, and upregulation of Bcl-2.	Quercetin	37-46	BCL2 apoptosis regulator	Homo sapiens	109-114
33363176-0	2020	Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	87-92
33325451-2	2020	Network pharmacology was utilized to assess the hepatoprotective effects of quercetin (Que)-containing AR, and to validate the anti-liver injury effects of Que in a mouse model of liver injury.	Quercetin	76-85	ferredoxin reductase	Mus musculus	103-105
33325451-2	2020	Network pharmacology was utilized to assess the hepatoprotective effects of quercetin (Que)-containing AR, and to validate the anti-liver injury effects of Que in a mouse model of liver injury.	Quercetin	87-90	ferredoxin reductase	Mus musculus	103-105
33122058-0	2020	Multi-spectroscopic investigation, molecular docking and molecular dynamic simulation of competitive interactions between flavonoids (quercetin and rutin) and sorafenib for binding to human serum albumin.	Quercetin	134-143	albumin	Homo sapiens	190-203
33122058-2	2020	The aim of this study was to evaluate anticancer drug sorafenib displacement from the binding site on human serum albumin by commonly used plant flavonoids quercetin and rutin.	Quercetin	156-165	albumin	Homo sapiens	108-121
32829158-5	2020	The detection limit (LOD) and the quantitation limit (LOQ) values for quercetin were calculated as 0.07 mug mL-1 and 0.24 mug mL-1, respectively.	Quercetin	70-79	L1 cell adhesion molecule	Mus musculus	108-112
32829158-5	2020	The detection limit (LOD) and the quantitation limit (LOQ) values for quercetin were calculated as 0.07 mug mL-1 and 0.24 mug mL-1, respectively.	Quercetin	70-79	L1 cell adhesion molecule	Mus musculus	126-130
33381536-11	2020	The spermatozoa leaked AST was markedly lower at 5.0, 10 (P < 0.001) and 20 muM (P < 0.05) of quercetin.	Quercetin	94-103	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	23-26
33305630-8	2020	The mRNA expressions of vascular endothelial growth factor, transforming growth factor-beta1, and interluekin-10 were markedly upregulated in healing tissues of quercetin-treated groups.	Quercetin	161-170	transforming growth factor, beta 1	Rattus norvegicus	60-92
33305630-9	2020	Tumor necrosis factor-alpha mRNA expression and protein levels were lowered by quercetin treatment.	Quercetin	79-88	tumor necrosis factor	Rattus norvegicus	0-27
33305630-10	2020	Quercetin-treated groups also showed increased activities of SOD (superoxide dismutase) and catalase, and levels of total thiols in wound tissues on day 7.	Quercetin	0-9	catalase	Rattus norvegicus	92-100
33306006-0	2020	Quercetin acts as a P-gp modulator via impeding signal transduction from nucleotide-binding domain to transmembrane domain.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	20-24
33306006-6	2020	Among them, quercetin has revealed a great potential to modulate P-gp activity.	Quercetin	12-21	ATP binding cassette subfamily B member 1	Homo sapiens	65-69
33306006-8	2020	In the present work, we showed that quercetin binds in the interacting region between the transmembrane domain and nucleotide-binding domain out of the three plausible binding sites of P-gp and restrict the conformational change from inward- to outward-facing conformation of P-gp.	Quercetin	36-45	ATP binding cassette subfamily B member 1	Homo sapiens	185-189
33306006-8	2020	In the present work, we showed that quercetin binds in the interacting region between the transmembrane domain and nucleotide-binding domain out of the three plausible binding sites of P-gp and restrict the conformational change from inward- to outward-facing conformation of P-gp.	Quercetin	36-45	ATP binding cassette subfamily B member 1	Homo sapiens	276-280
33306006-11	2020	Our work reveals the mechanistic understanding of quercetin induced modulation of P-gp and indicates its importance in cancer treatment.	Quercetin	50-59	ATP binding cassette subfamily B member 1	Homo sapiens	82-86
33363176-3	2020	Quercetin, a natural flavonoid possessing a specific effect of autophagy stimulation and SIRT1 activation, showed some protective effect on a series of degenerative diseases.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	89-94
33362534-0	2020	Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor/Akt Signaling Pathway in Acute Myeloid Leukemia Cells.	Quercetin	0-9	vascular endothelial growth factor A	Homo sapiens	50-84
33363176-4	2020	Based on previous studies, we hypothesized that quercetin might have therapeutic effects on IDD by inhibiting the apoptosis of NP cells and dyshomeostasis of ECM via the SIRT1-autophagy pathway.	Quercetin	48-57	sirtuin 1	Rattus norvegicus	170-175
33362534-0	2020	Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor/Akt Signaling Pathway in Acute Myeloid Leukemia Cells.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	85-88
33363176-6	2020	We also found that quercetin promoted the expression of SIRT1 and autophagy in NP cells in a dose-dependent manner.	Quercetin	19-28	sirtuin 1	Rattus norvegicus	56-61
33362534-5	2020	Second, we found that quercetin-induced apoptosis depends on the decrease of mitochondria membrane potential (MMP) and Bcl-2 proteins.	Quercetin	22-31	BCL2 apoptosis regulator	Homo sapiens	119-124
33363176-8	2020	Moreover, SIRT1 enzymatic activity inhibitor EX-527, suppressed quercetin-induced autophagy and the protective effect on NP cells, indicating that quercetin protected NP cells against apoptosis and prevented ECM degeneration via SIRT1-autophagy pathway.	Quercetin	64-73	sirtuin 1	Rattus norvegicus	10-15
33362534-6	2020	With quantitative chemical proteomics, we observed the downregulation of VEGFR2 and PI3K/Akt signaling in quercetin-treated cells.	Quercetin	106-115	kinase insert domain receptor	Homo sapiens	73-79
33362534-6	2020	With quantitative chemical proteomics, we observed the downregulation of VEGFR2 and PI3K/Akt signaling in quercetin-treated cells.	Quercetin	106-115	AKT serine/threonine kinase 1	Homo sapiens	89-92
33362534-7	2020	Consistently, cell studies also identified that VEGFR2 and PI3K/Akt signaling pathways are involved in the action of quercetin on mitochondria and Bcl-2 proteins.	Quercetin	117-126	kinase insert domain receptor	Homo sapiens	48-54
33362534-7	2020	Consistently, cell studies also identified that VEGFR2 and PI3K/Akt signaling pathways are involved in the action of quercetin on mitochondria and Bcl-2 proteins.	Quercetin	117-126	AKT serine/threonine kinase 1	Homo sapiens	64-67
33362534-7	2020	Consistently, cell studies also identified that VEGFR2 and PI3K/Akt signaling pathways are involved in the action of quercetin on mitochondria and Bcl-2 proteins.	Quercetin	117-126	BCL2 apoptosis regulator	Homo sapiens	147-152
33362534-8	2020	The decrease of MMP and cell death could be rescued when PI3K/Akt signaling is activated, suggesting that VEGFR2 and PI3K/Akt exert as upstream regulators for quercetin effect on apoptosis induction in AML cells.	Quercetin	159-168	AKT serine/threonine kinase 1	Homo sapiens	62-65
33363176-8	2020	Moreover, SIRT1 enzymatic activity inhibitor EX-527, suppressed quercetin-induced autophagy and the protective effect on NP cells, indicating that quercetin protected NP cells against apoptosis and prevented ECM degeneration via SIRT1-autophagy pathway.	Quercetin	64-73	sirtuin 1	Rattus norvegicus	229-234
33362534-8	2020	The decrease of MMP and cell death could be rescued when PI3K/Akt signaling is activated, suggesting that VEGFR2 and PI3K/Akt exert as upstream regulators for quercetin effect on apoptosis induction in AML cells.	Quercetin	159-168	kinase insert domain receptor	Homo sapiens	106-112
33362534-8	2020	The decrease of MMP and cell death could be rescued when PI3K/Akt signaling is activated, suggesting that VEGFR2 and PI3K/Akt exert as upstream regulators for quercetin effect on apoptosis induction in AML cells.	Quercetin	159-168	AKT serine/threonine kinase 1	Homo sapiens	122-125
33363176-8	2020	Moreover, SIRT1 enzymatic activity inhibitor EX-527, suppressed quercetin-induced autophagy and the protective effect on NP cells, indicating that quercetin protected NP cells against apoptosis and prevented ECM degeneration via SIRT1-autophagy pathway.	Quercetin	147-156	sirtuin 1	Rattus norvegicus	10-15
33362534-9	2020	In conclusion, our findings from this study provide convincing evidence that quercetin induces cell death via downregulation of VEGF/Akt signaling pathways and mitochondria-mediated apoptosis in AML cells.	Quercetin	77-86	vascular endothelial growth factor A	Homo sapiens	128-132
33362534-9	2020	In conclusion, our findings from this study provide convincing evidence that quercetin induces cell death via downregulation of VEGF/Akt signaling pathways and mitochondria-mediated apoptosis in AML cells.	Quercetin	77-86	AKT serine/threonine kinase 1	Homo sapiens	133-136
33363176-8	2020	Moreover, SIRT1 enzymatic activity inhibitor EX-527, suppressed quercetin-induced autophagy and the protective effect on NP cells, indicating that quercetin protected NP cells against apoptosis and prevented ECM degeneration via SIRT1-autophagy pathway.	Quercetin	147-156	sirtuin 1	Rattus norvegicus	229-234
33363176-10	2020	Taken together, our results suggest that quercetin prevents IDD by promoting SIRT1-dependent autophagy, indicating one novel and effective therapeutic method for IDD.	Quercetin	41-50	sirtuin 1	Rattus norvegicus	77-82
33292691-3	2020	There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm.	Quercetin	101-110	NFE2 like bZIP transcription factor 2	Homo sapiens	15-19
33140889-12	2020	Six active compounds of LQC can enter the active pocket of Akt1, namely beta-carotene, kaempferol, luteolin, naringenin, quercetin and wogonin, thereby exerting potential therapeutic effects in COVID-19.	Quercetin	121-130	AKT serine/threonine kinase 1	Homo sapiens	59-63
33425996-10	2020	Accordingly, we found the effective compound of XFZYD (quercetin) decreased intracellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expressions and pro-inflammatory cytokines in HUVECs treated with lipopolysaccharide (LPS), and reduced the adhesion function of HUVECs with monocytes.	Quercetin	55-64	intercellular adhesion molecule 1	Homo sapiens	76-109
33425996-10	2020	Accordingly, we found the effective compound of XFZYD (quercetin) decreased intracellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expressions and pro-inflammatory cytokines in HUVECs treated with lipopolysaccharide (LPS), and reduced the adhesion function of HUVECs with monocytes.	Quercetin	55-64	intercellular adhesion molecule 1	Homo sapiens	111-117
33425996-10	2020	Accordingly, we found the effective compound of XFZYD (quercetin) decreased intracellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expressions and pro-inflammatory cytokines in HUVECs treated with lipopolysaccharide (LPS), and reduced the adhesion function of HUVECs with monocytes.	Quercetin	55-64	vascular cell adhesion molecule 1	Homo sapiens	123-156
33425996-10	2020	Accordingly, we found the effective compound of XFZYD (quercetin) decreased intracellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expressions and pro-inflammatory cytokines in HUVECs treated with lipopolysaccharide (LPS), and reduced the adhesion function of HUVECs with monocytes.	Quercetin	55-64	vascular cell adhesion molecule 1	Homo sapiens	158-164
33142229-0	2020	Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators.	Quercetin	64-73	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	108-114
33142229-3	2020	Therefore, several quercetin hybrid derivatives were designed and synthesized to produce a more selective KCa1.1 channel stimulator, then assessed both in silico and in vitro.	Quercetin	19-28	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	106-112
33142229-6	2020	The lipoyl derivatives 1F and 3F, though showing pharmacological and electrophysiological features similar to those of quercetin, seemed to be more effective as KCa1.1 channel stimulators as compared to the parent compound.	Quercetin	119-128	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	161-167
33142229-7	2020	The strategy pursued demonstrated how different chemical substituents on the quercetin core can change/invert its effect on CaV1.2 channels or enhance its KCa1.1 channel stimulatory activity, thus opening new avenues for the synthesis of efficacious vasorelaxant quercetin hybrids.	Quercetin	77-86	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	124-130
33142229-7	2020	The strategy pursued demonstrated how different chemical substituents on the quercetin core can change/invert its effect on CaV1.2 channels or enhance its KCa1.1 channel stimulatory activity, thus opening new avenues for the synthesis of efficacious vasorelaxant quercetin hybrids.	Quercetin	77-86	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	155-161
33425996-11	2020	The inhibitor of the predicted target protein (PTGS2) could further reduce the expressions of VCAM-1, ICAM-1, and TNF-alpha induced by LPS, and inhibit the adhesion function of HUVECs with monocytes, while PTGS2 agonists partially counteracted the protective effect of quercetin.	Quercetin	269-278	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
33425996-11	2020	The inhibitor of the predicted target protein (PTGS2) could further reduce the expressions of VCAM-1, ICAM-1, and TNF-alpha induced by LPS, and inhibit the adhesion function of HUVECs with monocytes, while PTGS2 agonists partially counteracted the protective effect of quercetin.	Quercetin	269-278	intercellular adhesion molecule 1	Homo sapiens	102-108
33425996-11	2020	The inhibitor of the predicted target protein (PTGS2) could further reduce the expressions of VCAM-1, ICAM-1, and TNF-alpha induced by LPS, and inhibit the adhesion function of HUVECs with monocytes, while PTGS2 agonists partially counteracted the protective effect of quercetin.	Quercetin	269-278	prostaglandin-endoperoxide synthase 2	Homo sapiens	206-211
33425996-13	2020	The effective component quercetin was verified to protect endothelial cells by reducing endothelial inflammatory response and impeding the attachment of monocytes against the predicted therapeutic target PTGS2.	Quercetin	24-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	204-209
33200005-11	2020	Therefore, quercetin may have promising potential in ameliorating atherosclerotic pathophysiology in the rat carotid artery by inhibiting oxidative stress and inflammatory responses mechanistically by modulating the AMPK/SIRT1/NF-kappaB signaling pathway.	Quercetin	11-20	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	216-220
32232643-2	2020	The aim of this study was to investigate the effect of lead acetate and quercetin on tight (claudin 11 and occludin) and gap junctional (connexin 43) proteins and the integrity of the blood-testis barrier status.	Quercetin	72-81	claudin 11	Mus musculus	92-102
32232643-2	2020	The aim of this study was to investigate the effect of lead acetate and quercetin on tight (claudin 11 and occludin) and gap junctional (connexin 43) proteins and the integrity of the blood-testis barrier status.	Quercetin	72-81	occludin	Mus musculus	107-115
33200005-0	2020	Quercetin modulates AMPK/SIRT1/NF-kappaB signaling to inhibit inflammatory/oxidative stress responses in diabetic high fat diet-induced atherosclerosis in the rat carotid artery.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	20-24
33357723-5	2020	The results showed that quercetin significantly up-regulated the expression of chondrogenesis genes and stimulated the secretion of GAG (glycosaminoglycan) through activating the ERK, P38 and AKT signalling pathways in a dose-dependent manner.	Quercetin	24-33	Eph receptor B1	Rattus norvegicus	179-182
33357723-5	2020	The results showed that quercetin significantly up-regulated the expression of chondrogenesis genes and stimulated the secretion of GAG (glycosaminoglycan) through activating the ERK, P38 and AKT signalling pathways in a dose-dependent manner.	Quercetin	24-33	mitogen activated protein kinase 14	Rattus norvegicus	184-187
33357723-5	2020	The results showed that quercetin significantly up-regulated the expression of chondrogenesis genes and stimulated the secretion of GAG (glycosaminoglycan) through activating the ERK, P38 and AKT signalling pathways in a dose-dependent manner.	Quercetin	24-33	AKT serine/threonine kinase 1	Rattus norvegicus	192-195
33520015-11	2020	Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol.	Quercetin	133-142	tumor necrosis factor	Homo sapiens	27-30
33520015-11	2020	Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol.	Quercetin	133-142	interleukin 10	Homo sapiens	32-37
33520015-11	2020	Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol.	Quercetin	133-142	interleukin 2	Homo sapiens	39-43
33520015-11	2020	Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol.	Quercetin	133-142	interleukin 6	Homo sapiens	45-49
33520015-11	2020	Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol.	Quercetin	133-142	signal transducer and activator of transcription 1	Homo sapiens	51-56
33520015-11	2020	Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol.	Quercetin	133-142	C-C motif chemokine ligand 2	Homo sapiens	61-65
33200005-0	2020	Quercetin modulates AMPK/SIRT1/NF-kappaB signaling to inhibit inflammatory/oxidative stress responses in diabetic high fat diet-induced atherosclerosis in the rat carotid artery.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	25-30
33200005-8	2020	Additionally, the inflammatory response was suppressed by quercetin administration, as indicated by the reduced NF-kappaB and IL-1beta levels, and increased IL-10 levels.	Quercetin	58-67	interleukin 1 alpha	Rattus norvegicus	126-134
33200005-8	2020	Additionally, the inflammatory response was suppressed by quercetin administration, as indicated by the reduced NF-kappaB and IL-1beta levels, and increased IL-10 levels.	Quercetin	58-67	interleukin 10	Rattus norvegicus	157-162
33200005-11	2020	Therefore, quercetin may have promising potential in ameliorating atherosclerotic pathophysiology in the rat carotid artery by inhibiting oxidative stress and inflammatory responses mechanistically by modulating the AMPK/SIRT1/NF-kappaB signaling pathway.	Quercetin	11-20	sirtuin 1	Rattus norvegicus	221-226
33200005-9	2020	Furthermore, SIRT1 expression was revealed to be significantly increased in response to quercetin treatment compared with non-treated HFD rats.	Quercetin	88-97	sirtuin 1	Rattus norvegicus	13-18
33200005-10	2020	However, these effects of quercetin were abolished or reversed by the administration of compound-C (0.2 mg/kg), a specific AMPK blocker, in HFD rats.	Quercetin	26-35	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	123-127
32944799-0	2020	Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation.	Quercetin	0-9	toll-like receptor 4	Mus musculus	113-117
32944799-8	2020	Second, quercetin inhibited OGD-induced expression of inflammatory factors in BV2 cells and suppressed TLR4/MyD88/NF-kappaB signaling.	Quercetin	8-17	toll-like receptor 4	Mus musculus	103-107
32944799-8	2020	Second, quercetin inhibited OGD-induced expression of inflammatory factors in BV2 cells and suppressed TLR4/MyD88/NF-kappaB signaling.	Quercetin	8-17	myeloid differentiation primary response gene 88	Mus musculus	108-113
32944799-8	2020	Second, quercetin inhibited OGD-induced expression of inflammatory factors in BV2 cells and suppressed TLR4/MyD88/NF-kappaB signaling.	Quercetin	8-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	114-123
32944799-10	2020	CONCLUSION: These results suggest that the neuroprotective effect of quercetin in HIBI mice is partially due to the inhibition of oxidative stress and TLR4-mediated inflammatory responses in activated microglia.	Quercetin	69-78	toll-like receptor 4	Mus musculus	151-155
33901998-1	2020	This study tested if the protective effect of quercetin (QUR) against experimentally-induced acute myocardial infarction (AMI) in rats involves modulating the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway.	Quercetin	46-55	Janus kinase 2	Rattus norvegicus	226-230
33901998-0	2020	Quercetin protects against experimentally-induced myocardial infarction in rats by an antioxidant potential and concomitant activation of signal transducer and activator of transcription 3.	Quercetin	0-9	signal transducer and activator of transcription 3	Rattus norvegicus	138-188
33901998-1	2020	This study tested if the protective effect of quercetin (QUR) against experimentally-induced acute myocardial infarction (AMI) in rats involves modulating the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway.	Quercetin	46-55	Janus kinase 2	Rattus norvegicus	159-173
33901998-1	2020	This study tested if the protective effect of quercetin (QUR) against experimentally-induced acute myocardial infarction (AMI) in rats involves modulating the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway.	Quercetin	46-55	signal transducer and activator of transcription 3	Rattus norvegicus	174-224
33901998-1	2020	This study tested if the protective effect of quercetin (QUR) against experimentally-induced acute myocardial infarction (AMI) in rats involves modulating the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway.	Quercetin	46-55	signal transducer and activator of transcription 3	Rattus norvegicus	231-236
33038355-0	2020	Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-kappaB, ATF-6 pathways and activating Nrf2, Akt pathways.	Quercetin	0-9	caspase 3	Rattus norvegicus	111-120
32813234-0	2020	Quercetin Ameliorates CFA-Induced Chronic Inflammatory Hyperalgesia via Modulation of ROS-Mediated ERK1/2 Signaling and Inhibition of Spinal Glial Activation In Vivo.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	99-105
32813234-12	2020	All the molecular modulators of hyperalgesia were brought towards normal after quercetin treatment showing its anti-hyperalgesic activity, indicating that repeated quercetin treatment is able to alleviate chronic inflammatory hyperalgesia by attenuating TNF-alpha-TNFR1-ERK1/2 signaling pathway via modulation of ROS and by suppression of central sensitization via inhibition of spinal glial activation.	Quercetin	79-88	tumor necrosis factor	Homo sapiens	254-263
32813234-12	2020	All the molecular modulators of hyperalgesia were brought towards normal after quercetin treatment showing its anti-hyperalgesic activity, indicating that repeated quercetin treatment is able to alleviate chronic inflammatory hyperalgesia by attenuating TNF-alpha-TNFR1-ERK1/2 signaling pathway via modulation of ROS and by suppression of central sensitization via inhibition of spinal glial activation.	Quercetin	164-173	tumor necrosis factor	Homo sapiens	254-263
32813234-12	2020	All the molecular modulators of hyperalgesia were brought towards normal after quercetin treatment showing its anti-hyperalgesic activity, indicating that repeated quercetin treatment is able to alleviate chronic inflammatory hyperalgesia by attenuating TNF-alpha-TNFR1-ERK1/2 signaling pathway via modulation of ROS and by suppression of central sensitization via inhibition of spinal glial activation.	Quercetin	164-173	TNF receptor superfamily member 1A	Homo sapiens	264-269
32813234-12	2020	All the molecular modulators of hyperalgesia were brought towards normal after quercetin treatment showing its anti-hyperalgesic activity, indicating that repeated quercetin treatment is able to alleviate chronic inflammatory hyperalgesia by attenuating TNF-alpha-TNFR1-ERK1/2 signaling pathway via modulation of ROS and by suppression of central sensitization via inhibition of spinal glial activation.	Quercetin	164-173	mitogen-activated protein kinase 3	Homo sapiens	270-276
33038355-0	2020	Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-kappaB, ATF-6 pathways and activating Nrf2, Akt pathways.	Quercetin	0-9	activating transcription factor 6	Rattus norvegicus	133-138
33038355-0	2020	Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-kappaB, ATF-6 pathways and activating Nrf2, Akt pathways.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	163-167
33038355-0	2020	Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-kappaB, ATF-6 pathways and activating Nrf2, Akt pathways.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	169-172
33038355-7	2020	However, quercetin was determined to relieve oxidative stress, oxidative DNA damage, neuronal cell damage, inflammation, ER stress, and apoptosis caused by vincristine and enable Akt activation.	Quercetin	9-18	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
33260381-3	2020	Morin, quercetin, and fucoxanthin inhibited the enzyme activity of CYP1A2 and CYP3A4 in a dose-dependent manner.	Quercetin	7-16	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	67-73
33260381-3	2020	Morin, quercetin, and fucoxanthin inhibited the enzyme activity of CYP1A2 and CYP3A4 in a dose-dependent manner.	Quercetin	7-16	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	78-84
33260381-4	2020	The IC50 values of morin, quercetin, and fucoxanthin were 41.8, 22.5, and 30.3 muM for CYP1A2 and 86.6, 16.1, and 24.4 muM for CYP3A4, respectively.	Quercetin	26-35	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	87-93
33260381-4	2020	The IC50 values of morin, quercetin, and fucoxanthin were 41.8, 22.5, and 30.3 muM for CYP1A2 and 86.6, 16.1, and 24.4 muM for CYP3A4, respectively.	Quercetin	26-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	127-133
32768503-7	2020	Cyanidin may inhibit RNA polymerase function and, Quercetin is found to block interaction sites on the viral spike.	Quercetin	50-59	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	109-114
33179911-0	2020	Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity.	Quercetin	0-9	angiotensin converting enzyme 2	Homo sapiens	56-87
33179911-0	2020	Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity.	Quercetin	0-9	angiotensin converting enzyme 2	Homo sapiens	89-93
33213346-0	2021	Cholinesterase Inhibitory Potential of Quercetin towards Alzheimer"s Disease - A Promising Natural Molecule or Fashion of the Day?	Quercetin	39-48	butyrylcholinesterase	Homo sapiens	0-14
33213346-6	2021	However, there is no review published so far summarizing the effect of quercetin on the cholinesterase (ChE) enzymes related to the cholinergic hypothesis, which is one of the pathological mechanisms of Alzheimer"s disease (AD).	Quercetin	71-80	butyrylcholinesterase	Homo sapiens	88-102
33213346-6	2021	However, there is no review published so far summarizing the effect of quercetin on the cholinesterase (ChE) enzymes related to the cholinergic hypothesis, which is one of the pathological mechanisms of Alzheimer"s disease (AD).	Quercetin	71-80	butyrylcholinesterase	Homo sapiens	104-107
33213346-8	2021	Although the number of studies on the ChE inhibitory effect of quercetin is limited, it deserves to be discussed in a review article.	Quercetin	63-72	butyrylcholinesterase	Homo sapiens	38-41
33213346-9	2021	With this sensitivity, the neuroprotective effect of quercetin against AD through ChE inhibition was scrutinized in the current review study.	Quercetin	53-62	butyrylcholinesterase	Homo sapiens	82-85
33177495-8	2020	Further, this study demonstrates that quercetin reduces ROS via SIRT3-mediated acetylation of SOD2"s K68 residue.	Quercetin	38-47	sirtuin 3	Homo sapiens	64-69
33177495-8	2020	Further, this study demonstrates that quercetin reduces ROS via SIRT3-mediated acetylation of SOD2"s K68 residue.	Quercetin	38-47	superoxide dismutase 2	Homo sapiens	94-98
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	Quercetin	81-90	prostaglandin-endoperoxide synthase 1	Homo sapiens	213-218
33204288-12	2020	Molecular docking showed that quercetin, kaempferol, baicalein, and wogonin have good binding activity with IL6, VEGFA, EGFR, and NFKBIA targets.	Quercetin	30-39	interleukin 6	Homo sapiens	108-111
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	Quercetin	81-90	estrogen receptor 1	Homo sapiens	220-224
33204288-12	2020	Molecular docking showed that quercetin, kaempferol, baicalein, and wogonin have good binding activity with IL6, VEGFA, EGFR, and NFKBIA targets.	Quercetin	30-39	vascular endothelial growth factor A	Homo sapiens	113-118
33204288-12	2020	Molecular docking showed that quercetin, kaempferol, baicalein, and wogonin have good binding activity with IL6, VEGFA, EGFR, and NFKBIA targets.	Quercetin	30-39	epidermal growth factor receptor	Homo sapiens	120-124
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	Quercetin	81-90	progesterone receptor	Homo sapiens	230-233
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	Quercetin	81-90	cholinergic receptor muscarinic 3	Homo sapiens	235-240
33204288-12	2020	Molecular docking showed that quercetin, kaempferol, baicalein, and wogonin have good binding activity with IL6, VEGFA, EGFR, and NFKBIA targets.	Quercetin	30-39	NFKB inhibitor alpha	Homo sapiens	130-136
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	Quercetin	81-90	peroxisome proliferator activated receptor gamma	Homo sapiens	242-247
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	Quercetin	81-90	cholinergic receptor muscarinic 2	Homo sapiens	249-254
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	Quercetin	81-90	BCL2 apoptosis regulator	Homo sapiens	256-260
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	Quercetin	81-90	caspase 3	Homo sapiens	262-267
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	Quercetin	81-90	RELA proto-oncogene, NF-kB subunit	Homo sapiens	273-277
32585423-0	2020	Quercetin induces apoptosis in meningioma cells through the miR-197/IGFBP5 cascade.	Quercetin	0-9	microRNA 197	Homo sapiens	60-67
32934346-0	2020	Quercetin prevents bone loss in hindlimb suspension mice via stanniocalcin 1-mediated inhibition of osteoclastogenesis.	Quercetin	0-9	stanniocalcin 1	Mus musculus	61-76
32934346-7	2020	Treatment with Quer (1, 2, 5 muM) dose-dependently inhibited RANKL-induced osteoclastogenesis through promoting the expression of antioxidant hormone stanniocalcin 1 (STC1) and decreasing ROS generation; knockdown of STC1 blocked the inhibitory effect of Quer on ROS generation.	Quercetin	15-19	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	61-66
32934346-7	2020	Treatment with Quer (1, 2, 5 muM) dose-dependently inhibited RANKL-induced osteoclastogenesis through promoting the expression of antioxidant hormone stanniocalcin 1 (STC1) and decreasing ROS generation; knockdown of STC1 blocked the inhibitory effect of Quer on ROS generation.	Quercetin	15-19	stanniocalcin 1	Mus musculus	150-165
32934346-7	2020	Treatment with Quer (1, 2, 5 muM) dose-dependently inhibited RANKL-induced osteoclastogenesis through promoting the expression of antioxidant hormone stanniocalcin 1 (STC1) and decreasing ROS generation; knockdown of STC1 blocked the inhibitory effect of Quer on ROS generation.	Quercetin	15-19	stanniocalcin 1	Mus musculus	167-171
32934346-7	2020	Treatment with Quer (1, 2, 5 muM) dose-dependently inhibited RANKL-induced osteoclastogenesis through promoting the expression of antioxidant hormone stanniocalcin 1 (STC1) and decreasing ROS generation; knockdown of STC1 blocked the inhibitory effect of Quer on ROS generation.	Quercetin	15-19	stanniocalcin 1	Mus musculus	217-221
32986435-4	2020	Quercetin-Methyl-beta-Cyclodextrin (Que-Me-beta-CD) inclusion complexes were prepared, characterized and compared with the Que-HP-beta-CD complex using biophysical and computational methods (phase solubility, fluorescence and NMR Spectroscopy, Differential Scanning Calorimetry-DSC, Molecular Dynamics simulations-MDS), as candidates for preparation of nose-to-brain Quercetin"s delivery systems.	Quercetin	0-9	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	43-50
32986435-9	2020	Overall, water-solubility of lyophilized Que-Me-beta-CD and Que-HP-beta-CD products was approximately 7-40 times and 14-50 times as higher as for pure Quercetin at pH 1.2-6.8.	Quercetin	151-160	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	48-55
32986435-9	2020	Overall, water-solubility of lyophilized Que-Me-beta-CD and Que-HP-beta-CD products was approximately 7-40 times and 14-50 times as higher as for pure Quercetin at pH 1.2-6.8.	Quercetin	151-160	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	67-74
32530119-0	2020	Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor-positive breast cancer therapy: An in vitro study.	Quercetin	0-9	estrogen receptor 1	Homo sapiens	82-99
32530119-3	2020	As results, quercetin showed contrasting dose-response to cellular behaviors dependent on the ROS-regulated p53 signaling pathways.	Quercetin	12-21	tumor protein p53	Homo sapiens	108-111
32530119-6	2020	The real-time quantitative polymerase chain reaction analysis further implied that quercetin exerted its dual roles in tamoxifen-induced antiproliferative effects by regulated the gene expression involved in cell metastasis, cycle, and apoptosis through the ER pathways.	Quercetin	83-92	estrogen receptor 1	Homo sapiens	258-260
32530119-7	2020	Our present study provides a considerable support to the combination of quercetin and tamoxifen on human ER-positive breast carcinoma management.	Quercetin	72-81	estrogen receptor 1	Homo sapiens	105-107
32585423-0	2020	Quercetin induces apoptosis in meningioma cells through the miR-197/IGFBP5 cascade.	Quercetin	0-9	insulin like growth factor binding protein 5	Homo sapiens	68-74
32585423-7	2020	Quercetin treatment also decreases Bcl-2 and increases Bax protein expression, and increases miR-197 mRNA while reducing IGFBP5 mRNA expression.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	35-40
32585423-7	2020	Quercetin treatment also decreases Bcl-2 and increases Bax protein expression, and increases miR-197 mRNA while reducing IGFBP5 mRNA expression.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	55-58
32585423-7	2020	Quercetin treatment also decreases Bcl-2 and increases Bax protein expression, and increases miR-197 mRNA while reducing IGFBP5 mRNA expression.	Quercetin	0-9	microRNA 197	Homo sapiens	93-100
32585423-7	2020	Quercetin treatment also decreases Bcl-2 and increases Bax protein expression, and increases miR-197 mRNA while reducing IGFBP5 mRNA expression.	Quercetin	0-9	insulin like growth factor binding protein 5	Homo sapiens	121-127
32585423-9	2020	Quercetin may reduce meningioma cell proliferation and increase apoptosis by activating the miR-197/IGFBP5 cascade and regulating Bcl-2/Bax.	Quercetin	0-9	microRNA 197	Homo sapiens	92-99
32585423-9	2020	Quercetin may reduce meningioma cell proliferation and increase apoptosis by activating the miR-197/IGFBP5 cascade and regulating Bcl-2/Bax.	Quercetin	0-9	insulin like growth factor binding protein 5	Homo sapiens	100-106
32585423-9	2020	Quercetin may reduce meningioma cell proliferation and increase apoptosis by activating the miR-197/IGFBP5 cascade and regulating Bcl-2/Bax.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	130-135
32585423-9	2020	Quercetin may reduce meningioma cell proliferation and increase apoptosis by activating the miR-197/IGFBP5 cascade and regulating Bcl-2/Bax.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	136-139
33192517-3	2020	Treatment with flavonoids (naringenin, quercetin, and naringin) plus Balsamin for 48 h reduced HepG2 and MCF-7 cell viability, increased the activation of caspase-3 and -8, and induced apoptosis through up-regulation of pro-apoptotic genes and down-regulation of anti-apoptotic genes.	Quercetin	39-48	caspase 3	Homo sapiens	155-171
32919954-5	2020	Therapeutic relevance of PFKP was further evaluated using PFKP siRNA and Quercetin.	Quercetin	73-82	phosphofructokinase, platelet	Homo sapiens	25-29
32919954-7	2020	In MDA-MB-231 cells, quercetin treatment impaired PFKP-LDHA signaling axis thereby inhibiting aerobic glycolysis mediated increased migration of cancer cells.	Quercetin	21-30	phosphofructokinase, platelet	Homo sapiens	50-54
32919954-7	2020	In MDA-MB-231 cells, quercetin treatment impaired PFKP-LDHA signaling axis thereby inhibiting aerobic glycolysis mediated increased migration of cancer cells.	Quercetin	21-30	lactate dehydrogenase A	Homo sapiens	55-59
32898874-7	2020	However, an inhibitory effect of the identified quercetin-3-O-rhamnoside and its aglycone, quercetin, on the release of IL-8 and IL-6 could not be demonstrated.	Quercetin	48-57	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
32898874-7	2020	However, an inhibitory effect of the identified quercetin-3-O-rhamnoside and its aglycone, quercetin, on the release of IL-8 and IL-6 could not be demonstrated.	Quercetin	48-57	interleukin 6	Homo sapiens	129-133
33126698-7	2020	The presence of quercetin in adipo-induced hBM-MSC culture inhibited the adipogenic differentiation depicted as suppressed lipid accumulation and expression of adipogenesis markers such as PPARgamma, SREBP1c and C/EBPalpha.	Quercetin	16-25	peroxisome proliferator activated receptor gamma	Homo sapiens	189-198
33126698-7	2020	The presence of quercetin in adipo-induced hBM-MSC culture inhibited the adipogenic differentiation depicted as suppressed lipid accumulation and expression of adipogenesis markers such as PPARgamma, SREBP1c and C/EBPalpha.	Quercetin	16-25	sterol regulatory element binding transcription factor 1	Homo sapiens	200-207
33126698-7	2020	The presence of quercetin in adipo-induced hBM-MSC culture inhibited the adipogenic differentiation depicted as suppressed lipid accumulation and expression of adipogenesis markers such as PPARgamma, SREBP1c and C/EBPalpha.	Quercetin	16-25	CCAAT enhancer binding protein alpha	Homo sapiens	212-222
32338078-1	2020	Quercetin (QU) and rosmarinic acid (RA) were loaded in phosphatidic acid-liposomes (QU/RA-PA-liposomes) with surface apolipoprotein E (ApoE) using a process of thin-film hydration, followed by covalent crosslinking to activate biological pathways for penetrating the blood-brain barrier (BBB) and redeeming the neuronal apoptosis from attack of beta-amyloid1-42 (Abeta1-42) and neurofibrillary tangles.	Quercetin	0-9	apolipoprotein E	Rattus norvegicus	117-133
32338078-1	2020	Quercetin (QU) and rosmarinic acid (RA) were loaded in phosphatidic acid-liposomes (QU/RA-PA-liposomes) with surface apolipoprotein E (ApoE) using a process of thin-film hydration, followed by covalent crosslinking to activate biological pathways for penetrating the blood-brain barrier (BBB) and redeeming the neuronal apoptosis from attack of beta-amyloid1-42 (Abeta1-42) and neurofibrillary tangles.	Quercetin	0-9	apolipoprotein E	Rattus norvegicus	135-139
33218414-12	2020	Besides, the level of inactive beta-catenin protein level in the uterus of diabetic mice was higher than normal group; treatment with quercetin reduced the level of inactive beta-catenin protein as compared to diabetic mice.	Quercetin	134-143	catenin (cadherin associated protein), beta 1	Mus musculus	31-43
33218414-12	2020	Besides, the level of inactive beta-catenin protein level in the uterus of diabetic mice was higher than normal group; treatment with quercetin reduced the level of inactive beta-catenin protein as compared to diabetic mice.	Quercetin	134-143	catenin (cadherin associated protein), beta 1	Mus musculus	174-186
33142980-4	2020	A molecular docking study indicated that quercetin might bind the active site and binding pocket of PEDV 3C-like protease (3CLpro).	Quercetin	41-50	pedv 3c-like protease	None	100-121
33194005-9	2020	The present study provided the preliminary preclinical evidence that oral administration of Q or its derivatives was capable of improving bone pathology, bone-related parameters under imageology and bone maximum load, increasing serum osteocalcin, alkaline phosphatase, and estradiol, and reducing serum c-terminal cross-linked telopeptide of type I collagen (P < 0.05).	Quercetin	92-93	bone gamma-carboxyglutamate protein	Homo sapiens	235-246
33192484-9	2020	Moreover, MAPK1 and CYCS were markedly increased, but MAPT, PIK3R1, CASP8, and DAPK1 were markedly decreased after quercetin treatment in these HT-22 cells.	Quercetin	115-124	microtubule associated protein tau	Homo sapiens	54-58
32840291-0	2020	Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/beta-catenin/c-Myc/cyclin A2 signaling pathway.	Quercetin	0-9	estrogen receptor 1	Homo sapiens	71-88
32840291-0	2020	Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/beta-catenin/c-Myc/cyclin A2 signaling pathway.	Quercetin	0-9	catenin beta 1	Homo sapiens	89-101
32840291-0	2020	Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/beta-catenin/c-Myc/cyclin A2 signaling pathway.	Quercetin	0-9	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
32840291-0	2020	Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/beta-catenin/c-Myc/cyclin A2 signaling pathway.	Quercetin	0-9	cyclin A2	Homo sapiens	108-117
32840291-6	2020	Mechanistic studies showed that quercetin significantly upregulated the expressions of beta-catenin, c-Myc, and <protein-id="890;898">cyclins A2 and E1.	Quercetin	32-41	catenin beta 1	Homo sapiens	87-99
32840291-6	2020	Mechanistic studies showed that quercetin significantly upregulated the expressions of beta-catenin, c-Myc, and <protein-id="890;898">cyclins A2 and E1.	Quercetin	32-41	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	101-106
32840291-7	2020	Inhibitor</protein-id> for beta-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation.	Quercetin	73-82	catenin beta 1	Homo sapiens	27-39
32840291-7	2020	Inhibitor</protein-id> for beta-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation.	Quercetin	73-82	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	43-48
32840291-8	2020	The beta-catenin inhibitor XAV-939 suppressed quercetin-induced expressions of beta-catenin, c-Myc, and cyclins A2 and E1.	Quercetin	46-55	catenin beta 1	Homo sapiens	4-16
32840291-8	2020	The beta-catenin inhibitor XAV-939 suppressed quercetin-induced expressions of beta-catenin, c-Myc, and cyclins A2 and E1.	Quercetin	46-55	catenin beta 1	Homo sapiens	79-91
32840291-8	2020	The beta-catenin inhibitor XAV-939 suppressed quercetin-induced expressions of beta-catenin, c-Myc, and cyclins A2 and E1.	Quercetin	46-55	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	93-98
32840291-8	2020	The beta-catenin inhibitor XAV-939 suppressed quercetin-induced expressions of beta-catenin, c-Myc, and cyclins A2 and E1.	Quercetin	46-55	cyclin A2	Homo sapiens	104-121
32840291-9	2020	The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin.	Quercetin	82-91	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	4-9
32840291-9	2020	The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin.	Quercetin	82-91	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	59-64
32840291-9	2020	The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin.	Quercetin	82-91	cyclin A2	Homo sapiens	69-78
32840291-10	2020	Pretreatment of EpSCs with estrogen receptor (ER) antagonist ICI182780, but not the G protein-coupled ER1 antagonist G15, reversed quercetin-induced cell proliferation and upregulation of beta-catenin, c-Myc, and cyclin A2.	Quercetin	131-140	estrogen receptor 1	Homo sapiens	27-44
32840291-10	2020	Pretreatment of EpSCs with estrogen receptor (ER) antagonist ICI182780, but not the G protein-coupled ER1 antagonist G15, reversed quercetin-induced cell proliferation and upregulation of beta-catenin, c-Myc, and cyclin A2.	Quercetin	131-140	estrogen receptor 1	Homo sapiens	46-48
32840291-11	2020	Collectively, these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation of beta-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.	Quercetin	42-51	estrogen receptor 1	Homo sapiens	88-90
32840291-11	2020	Collectively, these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation of beta-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.	Quercetin	42-51	catenin beta 1	Homo sapiens	114-126
32840291-11	2020	Collectively, these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation of beta-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.	Quercetin	42-51	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	127-132
32840291-11	2020	Collectively, these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation of beta-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.	Quercetin	42-51	cyclin A2	Homo sapiens	133-141
32840291-11	2020	Collectively, these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation of beta-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.	Quercetin	42-51	cyclin E1	Homo sapiens	195-204
32840291-11	2020	Collectively, these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation of beta-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.	Quercetin	214-223	estrogen receptor 1	Homo sapiens	88-90
33192484-9	2020	Moreover, MAPK1 and CYCS were markedly increased, but MAPT, PIK3R1, CASP8, and DAPK1 were markedly decreased after quercetin treatment in these HT-22 cells.	Quercetin	115-124	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	60-66
33192484-9	2020	Moreover, MAPK1 and CYCS were markedly increased, but MAPT, PIK3R1, CASP8, and DAPK1 were markedly decreased after quercetin treatment in these HT-22 cells.	Quercetin	115-124	caspase 8	Mus musculus	68-73
33192484-9	2020	Moreover, MAPK1 and CYCS were markedly increased, but MAPT, PIK3R1, CASP8, and DAPK1 were markedly decreased after quercetin treatment in these HT-22 cells.	Quercetin	115-124	death associated protein kinase 1	Mus musculus	79-84
33192484-10	2020	Altogether, MAPT, PIK3R1, CASP8, DAPK1, MAPK1, and CYCS are all the biomarkers for AD diagnosis and the targets of quercetin treatment, and our findings may provide valuable biomarkers for AD diagnosis and treatment.	Quercetin	115-124	microtubule associated protein tau	Homo sapiens	12-16
33192484-10	2020	Altogether, MAPT, PIK3R1, CASP8, DAPK1, MAPK1, and CYCS are all the biomarkers for AD diagnosis and the targets of quercetin treatment, and our findings may provide valuable biomarkers for AD diagnosis and treatment.	Quercetin	115-124	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	18-24
33192484-10	2020	Altogether, MAPT, PIK3R1, CASP8, DAPK1, MAPK1, and CYCS are all the biomarkers for AD diagnosis and the targets of quercetin treatment, and our findings may provide valuable biomarkers for AD diagnosis and treatment.	Quercetin	115-124	caspase 8	Mus musculus	26-31
33192484-10	2020	Altogether, MAPT, PIK3R1, CASP8, DAPK1, MAPK1, and CYCS are all the biomarkers for AD diagnosis and the targets of quercetin treatment, and our findings may provide valuable biomarkers for AD diagnosis and treatment.	Quercetin	115-124	death associated protein kinase 1	Mus musculus	33-38
33192484-10	2020	Altogether, MAPT, PIK3R1, CASP8, DAPK1, MAPK1, and CYCS are all the biomarkers for AD diagnosis and the targets of quercetin treatment, and our findings may provide valuable biomarkers for AD diagnosis and treatment.	Quercetin	115-124	mitogen-activated protein kinase 1	Mus musculus	40-45
33192484-10	2020	Altogether, MAPT, PIK3R1, CASP8, DAPK1, MAPK1, and CYCS are all the biomarkers for AD diagnosis and the targets of quercetin treatment, and our findings may provide valuable biomarkers for AD diagnosis and treatment.	Quercetin	115-124	cytochrome c, somatic	Mus musculus	51-55
32822714-8	2020	Curcumin, quercetin, and atorvastatin treatment lead to down-regulation of miR-21 and TGFbeta1 and up-regulation of miR-122 in the BDL groups.	Quercetin	10-19	microRNA 21	Rattus norvegicus	75-81
32822714-0	2020	Effect of Atorvastatin, Curcumin, and Quercetin on miR-21 and miR-122 and their correlation with TGFbeta1 expression in experimental liver fibrosis.	Quercetin	38-47	microRNA 21	Rattus norvegicus	51-57
32822714-0	2020	Effect of Atorvastatin, Curcumin, and Quercetin on miR-21 and miR-122 and their correlation with TGFbeta1 expression in experimental liver fibrosis.	Quercetin	38-47	microRNA 122	Rattus norvegicus	62-69
32822714-8	2020	Curcumin, quercetin, and atorvastatin treatment lead to down-regulation of miR-21 and TGFbeta1 and up-regulation of miR-122 in the BDL groups.	Quercetin	10-19	transforming growth factor, beta 1	Rattus norvegicus	86-94
32822714-0	2020	Effect of Atorvastatin, Curcumin, and Quercetin on miR-21 and miR-122 and their correlation with TGFbeta1 expression in experimental liver fibrosis.	Quercetin	38-47	transforming growth factor, beta 1	Rattus norvegicus	97-105
32822714-4	2020	In the present study, we investigate the effects of curcumin, quercetin, and atorvastatin on the expression levels of miR-21 and miR-122 and evaluated their correlation with TGFbeta1 expression in bile duct ligation (BDL)-induced fibrotic rats.	Quercetin	62-71	microRNA 21	Rattus norvegicus	118-124
32822714-4	2020	In the present study, we investigate the effects of curcumin, quercetin, and atorvastatin on the expression levels of miR-21 and miR-122 and evaluated their correlation with TGFbeta1 expression in bile duct ligation (BDL)-induced fibrotic rats.	Quercetin	62-71	microRNA 122	Rattus norvegicus	129-136
32822714-8	2020	Curcumin, quercetin, and atorvastatin treatment lead to down-regulation of miR-21 and TGFbeta1 and up-regulation of miR-122 in the BDL groups.	Quercetin	10-19	microRNA 122	Rattus norvegicus	116-123
33066597-10	2020	Furthermore, downregulation of SIRT1 and SIRT6 by BLU9931 contributed to senescence induction, priming these cells for quercetin-induced death, a process termed senolysis.	Quercetin	119-128	sirtuin 1	Homo sapiens	31-36
33066597-10	2020	Furthermore, downregulation of SIRT1 and SIRT6 by BLU9931 contributed to senescence induction, priming these cells for quercetin-induced death, a process termed senolysis.	Quercetin	119-128	sirtuin 6	Homo sapiens	41-46
33052979-0	2020	Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1alpha and MDR1.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-164
33052979-0	2020	Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1alpha and MDR1.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	169-173
33052979-9	2020	In addition, our results indicated that the combination of anti-cancer drugs and quercetin down-regulated the expression of HIF-1alpha and increased the expression levels of the regulator of apoptosis p53.	Quercetin	81-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-134
33052979-9	2020	In addition, our results indicated that the combination of anti-cancer drugs and quercetin down-regulated the expression of HIF-1alpha and increased the expression levels of the regulator of apoptosis p53.	Quercetin	81-90	tumor protein p53	Homo sapiens	201-204
33052979-10	2020	Moreover, we observed that quercetin could inhibit the efflux activity of MDR1.	Quercetin	27-36	ATP binding cassette subfamily B member 1	Homo sapiens	74-78
33050575-4	2020	Luteolin, apigenin, quercetin, myricetin, rutin, naringenin, epicatechin, and genistein activate the Nrf2/ARE pathway in both normal and cancer cells.	Quercetin	20-29	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
32886481-8	2020	LC-MS analysis identified gallic acid, kaempferol 3-glucoside, kaempferol-3-O-beta-rutinoside, and quercetin which were subsequently shown to be strong alpha-Syn fibrillation inhibitors.	Quercetin	99-108	synuclein alpha	Homo sapiens	152-161
33134711-0	2020	Inhibiting CDK6 Activity by Quercetin Is an Attractive Strategy for Cancer Therapy.	Quercetin	28-37	cyclin dependent kinase 6	Homo sapiens	11-15
33134711-2	2020	We performed in silico and in vitro screening of different natural compounds and found that quercetin has a high binding affinity for the CDK6 and inhibits its activity with an IC50 = 5.89 muM.	Quercetin	92-101	cyclin dependent kinase 6	Homo sapiens	138-142
33134711-3	2020	Molecular docking and a 200 ns whole atom simulation of the CDK6-quercetin complex provide insights into the binding mechanism and stability of the complex.	Quercetin	65-74	cyclin dependent kinase 6	Homo sapiens	60-64
33134711-4	2020	Binding parameters ascertained by fluorescence and isothermal titration calorimetry studies revealed a binding constant in the range of 107 M-1 of quercetin to the CDK6.	Quercetin	147-156	cyclin dependent kinase 6	Homo sapiens	164-168
33134711-5	2020	Thermodynamic parameters associated with the formation of the CDK6-quercetin complex suggested an electrostatic interaction-driven process.	Quercetin	67-76	cyclin dependent kinase 6	Homo sapiens	62-66
33134711-6	2020	The cell-based protein expression studies in the breast (MCF-7) and lung (A549) cancer cells revealed that the treatment of quercetin decreases the expression of CDK6.	Quercetin	124-133	cyclin dependent kinase 6	Homo sapiens	162-166
33134711-8	2020	Moreover, quercetin induces apoptosis, by decreasing the production of reactive oxygen species and CDK6 expression.	Quercetin	10-19	cyclin dependent kinase 6	Homo sapiens	99-103
33134711-9	2020	Both in silico and in vitro studies highlight the significance of quercetin for the development of anticancer leads in terms of CDK6 inhibitors.	Quercetin	66-75	cyclin dependent kinase 6	Homo sapiens	128-132
33050645-5	2020	However, higher CAT and SOD activities, lower IL-17A and IL-22 levels, increased ZO-1 and occludin expressions, and lower Bacteroides abundance were found in the quercetin groups.	Quercetin	162-171	catalase	Mus musculus	16-19
33050645-5	2020	However, higher CAT and SOD activities, lower IL-17A and IL-22 levels, increased ZO-1 and occludin expressions, and lower Bacteroides abundance were found in the quercetin groups.	Quercetin	162-171	interleukin 17A	Mus musculus	46-52
33050645-5	2020	However, higher CAT and SOD activities, lower IL-17A and IL-22 levels, increased ZO-1 and occludin expressions, and lower Bacteroides abundance were found in the quercetin groups.	Quercetin	162-171	interleukin 22	Mus musculus	57-62
33050645-5	2020	However, higher CAT and SOD activities, lower IL-17A and IL-22 levels, increased ZO-1 and occludin expressions, and lower Bacteroides abundance were found in the quercetin groups.	Quercetin	162-171	tight junction protein 1	Mus musculus	81-85
33050645-5	2020	However, higher CAT and SOD activities, lower IL-17A and IL-22 levels, increased ZO-1 and occludin expressions, and lower Bacteroides abundance were found in the quercetin groups.	Quercetin	162-171	occludin	Mus musculus	90-98
32822152-4	2020	We explore the effectiveness of the polyphenols Epigallocatechin-3-gallate, Oleuropein aglycone, and quercetin on their ability to inhibit aggregation of amyloid-beta, tau, alpha-synuclein, and mitigate other pathological features for AD and PD.	Quercetin	101-110	synuclein alpha	Homo sapiens	173-188
33163337-5	2020	During the last decade, several products, including naturally occurring dietary agents as well as a wide variety of products from plant sources, including curcumin, quercetin, berberin, and ginsenosides, have been identified as potent modulators of the Wnt/beta-catenin signaling and have gained interest as promising candidates for the development of chemopreventive or therapeutic drugs for cancer.	Quercetin	165-174	catenin beta 1	Homo sapiens	257-269
33066828-0	2020	Quercetin regulates fibrogenic responses of endometrial stromal cell by upregulating miR-145 and inhibiting the TGF-beta1/Smad2/Smad3 pathway.	Quercetin	0-9	microRNA 145	Homo sapiens	85-92
33066828-0	2020	Quercetin regulates fibrogenic responses of endometrial stromal cell by upregulating miR-145 and inhibiting the TGF-beta1/Smad2/Smad3 pathway.	Quercetin	0-9	transforming growth factor beta 1	Homo sapiens	112-121
33066828-0	2020	Quercetin regulates fibrogenic responses of endometrial stromal cell by upregulating miR-145 and inhibiting the TGF-beta1/Smad2/Smad3 pathway.	Quercetin	0-9	SMAD family member 2	Homo sapiens	122-127
33066828-0	2020	Quercetin regulates fibrogenic responses of endometrial stromal cell by upregulating miR-145 and inhibiting the TGF-beta1/Smad2/Smad3 pathway.	Quercetin	0-9	SMAD family member 3	Homo sapiens	128-133
33066828-1	2020	OBJECTIVES: Aim of this study is to explore whether quercetin can inhibit the enlarged fibrogenic responses of endometrial stromal cells by increasing the level of microRNA-145 (miR-145) and mediating the TGFbeta1/Smad2/Smad3 signaling pathway, and to discuss the mechanism of signal transduction, further to provide experimental basis for revealing the pathophysiological mechanism and seeking new strategies for effective prevention and treatment of endometrial fibrosis.	Quercetin	52-61	microRNA 145	Homo sapiens	164-176
33066828-1	2020	OBJECTIVES: Aim of this study is to explore whether quercetin can inhibit the enlarged fibrogenic responses of endometrial stromal cells by increasing the level of microRNA-145 (miR-145) and mediating the TGFbeta1/Smad2/Smad3 signaling pathway, and to discuss the mechanism of signal transduction, further to provide experimental basis for revealing the pathophysiological mechanism and seeking new strategies for effective prevention and treatment of endometrial fibrosis.	Quercetin	52-61	microRNA 145	Homo sapiens	178-185
33066828-1	2020	OBJECTIVES: Aim of this study is to explore whether quercetin can inhibit the enlarged fibrogenic responses of endometrial stromal cells by increasing the level of microRNA-145 (miR-145) and mediating the TGFbeta1/Smad2/Smad3 signaling pathway, and to discuss the mechanism of signal transduction, further to provide experimental basis for revealing the pathophysiological mechanism and seeking new strategies for effective prevention and treatment of endometrial fibrosis.	Quercetin	52-61	transforming growth factor beta 1	Homo sapiens	205-213
33066828-1	2020	OBJECTIVES: Aim of this study is to explore whether quercetin can inhibit the enlarged fibrogenic responses of endometrial stromal cells by increasing the level of microRNA-145 (miR-145) and mediating the TGFbeta1/Smad2/Smad3 signaling pathway, and to discuss the mechanism of signal transduction, further to provide experimental basis for revealing the pathophysiological mechanism and seeking new strategies for effective prevention and treatment of endometrial fibrosis.	Quercetin	52-61	SMAD family member 2	Homo sapiens	214-219
33066828-1	2020	OBJECTIVES: Aim of this study is to explore whether quercetin can inhibit the enlarged fibrogenic responses of endometrial stromal cells by increasing the level of microRNA-145 (miR-145) and mediating the TGFbeta1/Smad2/Smad3 signaling pathway, and to discuss the mechanism of signal transduction, further to provide experimental basis for revealing the pathophysiological mechanism and seeking new strategies for effective prevention and treatment of endometrial fibrosis.	Quercetin	52-61	SMAD family member 3	Homo sapiens	220-225
33066828-9	2020	Furthermore, quercetin regulates cell fibrogenic responses of endometrial stromal cells via miR-145/TGF-beta1/Smad2/Smad3 pathway.	Quercetin	13-22	microRNA 145	Homo sapiens	92-99
33066828-9	2020	Furthermore, quercetin regulates cell fibrogenic responses of endometrial stromal cells via miR-145/TGF-beta1/Smad2/Smad3 pathway.	Quercetin	13-22	transforming growth factor beta 1	Homo sapiens	100-109
32798720-3	2020	QE-PEG-Ag2S was easily prepared via self-assembly of hydrophobic Ag2S NDs, amphiphilic pH-responsive PEG5k-PAE10k polymer, and an HSP70 inhibitor quercetin (QE).	Quercetin	146-155	angiotensin II receptor type 1	Homo sapiens	7-11
32798720-3	2020	QE-PEG-Ag2S was easily prepared via self-assembly of hydrophobic Ag2S NDs, amphiphilic pH-responsive PEG5k-PAE10k polymer, and an HSP70 inhibitor quercetin (QE).	Quercetin	0-2	angiotensin II receptor type 1	Homo sapiens	7-11
33066828-9	2020	Furthermore, quercetin regulates cell fibrogenic responses of endometrial stromal cells via miR-145/TGF-beta1/Smad2/Smad3 pathway.	Quercetin	13-22	SMAD family member 2	Homo sapiens	110-115
32563119-8	2020	Strikingly, resveratrol and quercetin at their realistic nanomolar concentrations acted additively in the mixture to abolish human AhR activation induced by various TCDD concentrations.	Quercetin	28-37	aryl hydrocarbon receptor	Homo sapiens	131-134
33066828-9	2020	Furthermore, quercetin regulates cell fibrogenic responses of endometrial stromal cells via miR-145/TGF-beta1/Smad2/Smad3 pathway.	Quercetin	13-22	SMAD family member 3	Homo sapiens	116-121
33066828-10	2020	CONCLUSIONS: These findings indicated that quercetin have a significant anti-fibrotic effect and could upregulate miR-145 and inhibit activation of TGF-beta1/Smad2/Smad3 pathway to regulate TGF-beta1 induced fibrogenic responses of endometrial stromal cells, which may serve as a potential therapeutic agent for endometrial fibrosis.	Quercetin	43-52	microRNA 145	Homo sapiens	114-121
33066828-10	2020	CONCLUSIONS: These findings indicated that quercetin have a significant anti-fibrotic effect and could upregulate miR-145 and inhibit activation of TGF-beta1/Smad2/Smad3 pathway to regulate TGF-beta1 induced fibrogenic responses of endometrial stromal cells, which may serve as a potential therapeutic agent for endometrial fibrosis.	Quercetin	43-52	transforming growth factor beta 1	Homo sapiens	148-157
33066828-10	2020	CONCLUSIONS: These findings indicated that quercetin have a significant anti-fibrotic effect and could upregulate miR-145 and inhibit activation of TGF-beta1/Smad2/Smad3 pathway to regulate TGF-beta1 induced fibrogenic responses of endometrial stromal cells, which may serve as a potential therapeutic agent for endometrial fibrosis.	Quercetin	43-52	SMAD family member 2	Homo sapiens	158-163
33066828-10	2020	CONCLUSIONS: These findings indicated that quercetin have a significant anti-fibrotic effect and could upregulate miR-145 and inhibit activation of TGF-beta1/Smad2/Smad3 pathway to regulate TGF-beta1 induced fibrogenic responses of endometrial stromal cells, which may serve as a potential therapeutic agent for endometrial fibrosis.	Quercetin	43-52	SMAD family member 3	Homo sapiens	164-169
33066828-10	2020	CONCLUSIONS: These findings indicated that quercetin have a significant anti-fibrotic effect and could upregulate miR-145 and inhibit activation of TGF-beta1/Smad2/Smad3 pathway to regulate TGF-beta1 induced fibrogenic responses of endometrial stromal cells, which may serve as a potential therapeutic agent for endometrial fibrosis.	Quercetin	43-52	transforming growth factor beta 1	Homo sapiens	190-199
32323384-0	2020	Quercetin supports bovine preimplantation embryo development under oxidative stress condition via activation of the Nrf2 signaling pathway.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Bos taurus	116-120
32329368-0	2020	Quercetin protects human oral keratinocytes from lipopolysaccharide-induced injury by downregulating microRNA-22.	Quercetin	0-9	microRNA 22	Homo sapiens	101-112
32329368-7	2020	Quercetin treatment led to significantly higher levels of p-PI3K, p-AKT, p-JAK1, and p-STAT3.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	68-71
32329368-7	2020	Quercetin treatment led to significantly higher levels of p-PI3K, p-AKT, p-JAK1, and p-STAT3.	Quercetin	0-9	Janus kinase 1	Homo sapiens	75-79
32329368-7	2020	Quercetin treatment led to significantly higher levels of p-PI3K, p-AKT, p-JAK1, and p-STAT3.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	87-92
32622308-8	2020	Quercetin supplementation to OVX mice for 4 weeks was able to ameliorate cognitive impairment by restoring HAT/HDAC homeostasis through ERK activation and reversing alterations in neuroplasticity markers in cortex and hippocampus of OVX mice.	Quercetin	0-9	mitogen-activated protein kinase 1	Mus musculus	136-139
32323384-8	2020	Moreover, quercetin supplementation induced mRNA and protein of Nrf2 with subsequent increase in the expression of downstream antioxidants namely: NQO1, PRDX1, CAT, and SOD1 antioxidants.	Quercetin	10-19	catalase	Bos taurus	160-163
32323384-8	2020	Moreover, quercetin supplementation induced mRNA and protein of Nrf2 with subsequent increase in the expression of downstream antioxidants namely: NQO1, PRDX1, CAT, and SOD1 antioxidants.	Quercetin	10-19	superoxide dismutase [Cu-Zn]	Bos taurus	169-173
32323384-9	2020	In conclusion, quercetin protects preimplantation embryos against oxidative stress and improves embryo viability through modulation of the Nrf2 signaling pathway.	Quercetin	15-24	NFE2 like bZIP transcription factor 2	Bos taurus	139-143
32329368-8	2020	These effects of quercetin were enhanced when miR-22 was knocked down and partly reversed when miR-22 was overexpressed.	Quercetin	17-26	microRNA 22	Homo sapiens	46-52
32329368-8	2020	These effects of quercetin were enhanced when miR-22 was knocked down and partly reversed when miR-22 was overexpressed.	Quercetin	17-26	microRNA 22	Homo sapiens	95-101
32329368-9	2020	CONCLUSION: Quercetin can mitigate LPS-induced injury in HOKs by downregulating miR-22, thereby activating PI3K/AKT and JAK1/STAT3 cascades.	Quercetin	12-21	microRNA 22	Homo sapiens	80-86
32329368-9	2020	CONCLUSION: Quercetin can mitigate LPS-induced injury in HOKs by downregulating miR-22, thereby activating PI3K/AKT and JAK1/STAT3 cascades.	Quercetin	12-21	AKT serine/threonine kinase 1	Homo sapiens	112-115
32329368-9	2020	CONCLUSION: Quercetin can mitigate LPS-induced injury in HOKs by downregulating miR-22, thereby activating PI3K/AKT and JAK1/STAT3 cascades.	Quercetin	12-21	Janus kinase 1	Homo sapiens	120-124
32329368-9	2020	CONCLUSION: Quercetin can mitigate LPS-induced injury in HOKs by downregulating miR-22, thereby activating PI3K/AKT and JAK1/STAT3 cascades.	Quercetin	12-21	signal transducer and activator of transcription 3	Homo sapiens	125-130
32988526-7	2020	In addition, quercetin (800 ppm) alleviated the decreased mRNA expression of mucin 2 (MUC2), which contributed to the intestinal chemical barrier (P = 0.039).	Quercetin	13-22	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	77-84
32988526-7	2020	In addition, quercetin (800 ppm) alleviated the decreased mRNA expression of mucin 2 (MUC2), which contributed to the intestinal chemical barrier (P = 0.039).	Quercetin	13-22	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	86-90
32988526-9	2020	In summary, these results indicated that quercetin ameliorated the oxidized oil-induced oxidative stress by upregulating the transcription of Nrf2 and its downstream genes to restore redox balance and reinforced the intestinal barrier via higher expression and secretion of MUC2 and facilitating the growth of Lactobacillus in the cecum.	Quercetin	41-50	nuclear factor, erythroid 2 like 2	Gallus gallus	142-146
32988526-9	2020	In summary, these results indicated that quercetin ameliorated the oxidized oil-induced oxidative stress by upregulating the transcription of Nrf2 and its downstream genes to restore redox balance and reinforced the intestinal barrier via higher expression and secretion of MUC2 and facilitating the growth of Lactobacillus in the cecum.	Quercetin	41-50	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	274-278
32323384-8	2020	Moreover, quercetin supplementation induced mRNA and protein of Nrf2 with subsequent increase in the expression of downstream antioxidants namely: NQO1, PRDX1, CAT, and SOD1 antioxidants.	Quercetin	10-19	NFE2 like bZIP transcription factor 2	Bos taurus	64-68
32323384-8	2020	Moreover, quercetin supplementation induced mRNA and protein of Nrf2 with subsequent increase in the expression of downstream antioxidants namely: NQO1, PRDX1, CAT, and SOD1 antioxidants.	Quercetin	10-19	NAD(P)H quinone dehydrogenase 1	Bos taurus	147-151
32323384-8	2020	Moreover, quercetin supplementation induced mRNA and protein of Nrf2 with subsequent increase in the expression of downstream antioxidants namely: NQO1, PRDX1, CAT, and SOD1 antioxidants.	Quercetin	10-19	peroxiredoxin 1	Bos taurus	153-158
33007902-9	2020	Elastin degradation was ameliorated in the quercetin-treated mice compared to that in the mice without quercetin treatment (degradation score 2.9 +- 0.3 vs 2.2 +- 0.2).	Quercetin	43-52	elastin	Mus musculus	0-7
32880455-0	2020	Quercetin Inhibited Endothelial Dysfunction and Atherosclerosis in Apolipoprotein E-Deficient Mice: Critical Roles for NADPH Oxidase and Heme Oxygenase-1.	Quercetin	0-9	apolipoprotein E	Mus musculus	67-83
32880455-0	2020	Quercetin Inhibited Endothelial Dysfunction and Atherosclerosis in Apolipoprotein E-Deficient Mice: Critical Roles for NADPH Oxidase and Heme Oxygenase-1.	Quercetin	0-9	heme oxygenase 1	Mus musculus	137-153
32880455-3	2020	Dietary quercetin treatment significantly suppressed endothelial dysfunction and aortic atherosclerosis in HFD-fed ApoE-/- mice (P < 0.05, all cases).	Quercetin	8-17	apolipoprotein E	Mus musculus	115-119
32880455-4	2020	Mechanistic studies demonstrated that dietary quercetin significantly attenuated p47phox expression and inhibited NADPH oxidase-derived oxidative stress in the aortas of HFD-fed ApoE-/- mice, while the expression and activity of antioxidant enzyme heme oxygenase-1 (HO-1) was enhanced after quercetin treatment (P < 0.05, all cases).	Quercetin	46-55	neutrophil cytosolic factor 1	Mus musculus	81-88
32880455-4	2020	Mechanistic studies demonstrated that dietary quercetin significantly attenuated p47phox expression and inhibited NADPH oxidase-derived oxidative stress in the aortas of HFD-fed ApoE-/- mice, while the expression and activity of antioxidant enzyme heme oxygenase-1 (HO-1) was enhanced after quercetin treatment (P < 0.05, all cases).	Quercetin	46-55	apolipoprotein E	Mus musculus	178-182
32880455-4	2020	Mechanistic studies demonstrated that dietary quercetin significantly attenuated p47phox expression and inhibited NADPH oxidase-derived oxidative stress in the aortas of HFD-fed ApoE-/- mice, while the expression and activity of antioxidant enzyme heme oxygenase-1 (HO-1) was enhanced after quercetin treatment (P < 0.05, all cases).	Quercetin	46-55	heme oxygenase 1	Mus musculus	248-264
32880455-4	2020	Mechanistic studies demonstrated that dietary quercetin significantly attenuated p47phox expression and inhibited NADPH oxidase-derived oxidative stress in the aortas of HFD-fed ApoE-/- mice, while the expression and activity of antioxidant enzyme heme oxygenase-1 (HO-1) was enhanced after quercetin treatment (P < 0.05, all cases).	Quercetin	46-55	heme oxygenase 1	Mus musculus	266-270
32880455-5	2020	In vitro, it was found that quercetin significantly attenuated NADPH oxidase-derived O2 - formation (75 +- 5.6% for quercetin versus 100 +- 6.0% for the control group, P < 0.01) in endothelial cells through induction of HO-1.	Quercetin	28-37	heme oxygenase 1	Mus musculus	220-224
32880455-6	2020	In addition, the favorable effects of quercetin on oxidant (i.e., H2O2)-induced endothelial dysfunction could be eliminated by tin protoporphyrin IX (an HO-1 inhibitor) or HO-1-specific siRNA.	Quercetin	38-47	heme oxygenase 1	Mus musculus	153-157
32880455-6	2020	In addition, the favorable effects of quercetin on oxidant (i.e., H2O2)-induced endothelial dysfunction could be eliminated by tin protoporphyrin IX (an HO-1 inhibitor) or HO-1-specific siRNA.	Quercetin	38-47	heme oxygenase 1	Mus musculus	172-176
32880455-7	2020	Our results demonstrated the critical roles of NADPH oxidase and HO-1 for the indirect antioxidant properties of quercetin in vascular diseases.	Quercetin	113-122	heme oxygenase 1	Mus musculus	65-69
32994439-0	2020	Quercetin-conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) increases Nrf2 expression via miR-27a mediation to prevent memory dysfunction in diabetic rats.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	85-89
32994439-0	2020	Quercetin-conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) increases Nrf2 expression via miR-27a mediation to prevent memory dysfunction in diabetic rats.	Quercetin	0-9	microRNA 27a	Rattus norvegicus	105-112
32994439-3	2020	The study aimed to evaluate the effects of quercetin (QC) and quercetin-conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) on Nrf2-controlled antioxidant genes through the redox-sensitive miR-27a.	Quercetin	43-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144
32994439-3	2020	The study aimed to evaluate the effects of quercetin (QC) and quercetin-conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) on Nrf2-controlled antioxidant genes through the redox-sensitive miR-27a.	Quercetin	62-71	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144
32994439-3	2020	The study aimed to evaluate the effects of quercetin (QC) and quercetin-conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) on Nrf2-controlled antioxidant genes through the redox-sensitive miR-27a.	Quercetin	62-71	microRNA 27a	Rattus norvegicus	202-209
33007902-9	2020	Elastin degradation was ameliorated in the quercetin-treated mice compared to that in the mice without quercetin treatment (degradation score 2.9 +- 0.3 vs 2.2 +- 0.2).	Quercetin	103-112	elastin	Mus musculus	0-7
33007902-10	2020	Furthermore, quercetin suppressed the expression of vascular cell adhesion molecule-1, macrophage infiltration, and pro-matrix metalloproteinase-9 activity.	Quercetin	13-22	vascular cell adhesion molecule 1	Mus musculus	52-85
32957369-0	2020	Quercetin inhibits TNF-alpha induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	19-28
32966478-10	2020	Biological pathway analysis showed that tumor necrosis factor (TNF), cytokine, and NF-kappaB signaling pathways were involved in the anti-inflammatory mechanisms of quercetin.	Quercetin	165-174	tumor necrosis factor	Mus musculus	40-61
32966478-10	2020	Biological pathway analysis showed that tumor necrosis factor (TNF), cytokine, and NF-kappaB signaling pathways were involved in the anti-inflammatory mechanisms of quercetin.	Quercetin	165-174	tumor necrosis factor	Mus musculus	63-66
32966478-10	2020	Biological pathway analysis showed that tumor necrosis factor (TNF), cytokine, and NF-kappaB signaling pathways were involved in the anti-inflammatory mechanisms of quercetin.	Quercetin	165-174	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	83-92
32966478-11	2020	Immunohistochemical staining further showed that quercetin reduced the activation of NF-kappaB, the expression of interleukin-1beta and TNF-alpha, and the infiltration of granulocytes in retinal tissues.	Quercetin	49-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
32966478-11	2020	Immunohistochemical staining further showed that quercetin reduced the activation of NF-kappaB, the expression of interleukin-1beta and TNF-alpha, and the infiltration of granulocytes in retinal tissues.	Quercetin	49-58	interleukin 1 beta	Mus musculus	114-131
32966478-11	2020	Immunohistochemical staining further showed that quercetin reduced the activation of NF-kappaB, the expression of interleukin-1beta and TNF-alpha, and the infiltration of granulocytes in retinal tissues.	Quercetin	49-58	tumor necrosis factor	Mus musculus	136-145
33061289-5	2020	Western blot analysis was employed to explore the effects of quercetin on the expression of MMP-2, MMP-9, Ezrin and Fascin proteins in cells.	Quercetin	61-70	matrix metallopeptidase 2	Homo sapiens	92-97
33061289-5	2020	Western blot analysis was employed to explore the effects of quercetin on the expression of MMP-2, MMP-9, Ezrin and Fascin proteins in cells.	Quercetin	61-70	matrix metallopeptidase 9	Homo sapiens	99-104
33061289-5	2020	Western blot analysis was employed to explore the effects of quercetin on the expression of MMP-2, MMP-9, Ezrin and Fascin proteins in cells.	Quercetin	61-70	ezrin	Homo sapiens	106-111
33061289-5	2020	Western blot analysis was employed to explore the effects of quercetin on the expression of MMP-2, MMP-9, Ezrin and Fascin proteins in cells.	Quercetin	61-70	fascin actin-bundling protein 1	Homo sapiens	116-122
33061289-10	2020	Finally, Western blot analysis demonstrated that invasion- and migration-related proteins (MMP-2, MMP-9, Erzin, and Fascin) were significantly downregulated with the quercetin concentration increasing.	Quercetin	166-175	matrix metallopeptidase 2	Homo sapiens	91-96
33061289-10	2020	Finally, Western blot analysis demonstrated that invasion- and migration-related proteins (MMP-2, MMP-9, Erzin, and Fascin) were significantly downregulated with the quercetin concentration increasing.	Quercetin	166-175	matrix metallopeptidase 9	Homo sapiens	98-103
33061289-10	2020	Finally, Western blot analysis demonstrated that invasion- and migration-related proteins (MMP-2, MMP-9, Erzin, and Fascin) were significantly downregulated with the quercetin concentration increasing.	Quercetin	166-175	fascin actin-bundling protein 1	Homo sapiens	116-122
32840549-4	2020	Furthermore, quercetin influenced global DNA methylation by upregulating DNA methyltransferase 1 (DNMT1) in both mRNA and protein expressions in a tissue specific manner.	Quercetin	13-22	DNA methyltransferase 1	Sus scrofa	73-96
32840549-4	2020	Furthermore, quercetin influenced global DNA methylation by upregulating DNA methyltransferase 1 (DNMT1) in both mRNA and protein expressions in a tissue specific manner.	Quercetin	13-22	DNA methyltransferase 1	Sus scrofa	98-103
32954977-0	2022	Probing intermolecular interactions and binding stability of kaempferol, quercetin and resveratrol derivatives with PPAR-gamma: docking, molecular dynamics and MM/GBSA approach to reveal potent PPAR- gamma agonist against cancer.	Quercetin	73-82	peroxisome proliferator activated receptor gamma	Homo sapiens	116-126
32954977-0	2022	Probing intermolecular interactions and binding stability of kaempferol, quercetin and resveratrol derivatives with PPAR-gamma: docking, molecular dynamics and MM/GBSA approach to reveal potent PPAR- gamma agonist against cancer.	Quercetin	73-82	peroxisome proliferator activated receptor gamma	Homo sapiens	194-205
32954977-2	2022	Herein, we examined a conformational analysis of 8708 derivatives of Kaempferol, Quercetin, and Resveratrol, the prime activators of PPAR-gamma molecular target by employing molecular docking and dynamic simulation pipeline to screen out potential agonists.	Quercetin	81-90	peroxisome proliferator activated receptor gamma	Homo sapiens	133-143
33014279-10	2020	Serum leptin and adiponectin contents were significantly increased by 0.04% and 0.06% dietary quercetin supplementation, compared with the control (P < 0.01).	Quercetin	94-103	leptin	Gallus gallus	6-12
32957369-0	2020	Quercetin inhibits TNF-alpha induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro.	Quercetin	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-104
32957369-2	2020	OBJECTIVE: The aim of this study was to investigate the mechanisms of how quercetin inhibits tumor necrosis factor alpha (TNF-alpha) induced human umbilical vein endothelial cells (HUVECs) apoptosis and inflammation.	Quercetin	74-83	tumor necrosis factor	Homo sapiens	93-120
33014279-10	2020	Serum leptin and adiponectin contents were significantly increased by 0.04% and 0.06% dietary quercetin supplementation, compared with the control (P < 0.01).	Quercetin	94-103	adiponectin, C1Q and collagen domain containing	Gallus gallus	17-28
32957369-2	2020	OBJECTIVE: The aim of this study was to investigate the mechanisms of how quercetin inhibits tumor necrosis factor alpha (TNF-alpha) induced human umbilical vein endothelial cells (HUVECs) apoptosis and inflammation.	Quercetin	74-83	tumor necrosis factor	Homo sapiens	122-131
32957369-6	2020	TNF-alpha induced elevated apoptosis rates and upregulation of VCAM-1, ICAM-1, and E-selectin were meaningfully reduced in HUVECs by pretreatment with quercetin.	Quercetin	151-160	tumor necrosis factor	Homo sapiens	0-9
32957369-6	2020	TNF-alpha induced elevated apoptosis rates and upregulation of VCAM-1, ICAM-1, and E-selectin were meaningfully reduced in HUVECs by pretreatment with quercetin.	Quercetin	151-160	vascular cell adhesion molecule 1	Homo sapiens	63-69
32957369-6	2020	TNF-alpha induced elevated apoptosis rates and upregulation of VCAM-1, ICAM-1, and E-selectin were meaningfully reduced in HUVECs by pretreatment with quercetin.	Quercetin	151-160	intercellular adhesion molecule 1	Homo sapiens	71-77
32957369-6	2020	TNF-alpha induced elevated apoptosis rates and upregulation of VCAM-1, ICAM-1, and E-selectin were meaningfully reduced in HUVECs by pretreatment with quercetin.	Quercetin	151-160	selectin E	Homo sapiens	83-93
32957369-7	2020	In addition, quercetin also inhibited the activation of AP-1and NF-kappaB.	Quercetin	13-22	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	56-60
32957369-7	2020	In addition, quercetin also inhibited the activation of AP-1and NF-kappaB.	Quercetin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	64-73
32957369-8	2020	CONCLUSION: Results indicate that quercetin could suppress TNF-alpha induced apoptosis and inflammation by blocking NF-kappaB and AP-1 signaling pathway in HUVECs, which might be one of the underlying mechanisms in treatment of coronary heart disease.	Quercetin	34-43	tumor necrosis factor	Homo sapiens	59-68
32957369-8	2020	CONCLUSION: Results indicate that quercetin could suppress TNF-alpha induced apoptosis and inflammation by blocking NF-kappaB and AP-1 signaling pathway in HUVECs, which might be one of the underlying mechanisms in treatment of coronary heart disease.	Quercetin	34-43	nuclear factor kappa B subunit 1	Homo sapiens	116-125
32957369-8	2020	CONCLUSION: Results indicate that quercetin could suppress TNF-alpha induced apoptosis and inflammation by blocking NF-kappaB and AP-1 signaling pathway in HUVECs, which might be one of the underlying mechanisms in treatment of coronary heart disease.	Quercetin	34-43	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-134
32924610-1	2021	To assess the effect of sequential treatment with Vitamin C (VC) and Quercetin (Q) on Nrf2-related oxidative stress in PC3 and DU145 cells, viability was measured by MTT assay.	Quercetin	69-78	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
32957884-5	2021	Previous studies have shown that quercetin reduces the entry of the virus into the cell by blocking the ACE2 receptor, as well as reducing the level of interleukin-6 in SARS and MERS patients.	Quercetin	33-42	angiotensin converting enzyme 2	Homo sapiens	104-108
32957884-5	2021	Previous studies have shown that quercetin reduces the entry of the virus into the cell by blocking the ACE2 receptor, as well as reducing the level of interleukin-6 in SARS and MERS patients.	Quercetin	33-42	interleukin 6	Homo sapiens	152-165
32702447-0	2020	Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis.	Quercetin	0-9	sirtuin 1	Homo sapiens	102-107
32702447-0	2020	Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis.	Quercetin	0-9	PTEN induced kinase 1	Homo sapiens	108-113
32702447-5	2020	We found that quercetin attenuated RTEC senescence induced by angiotensin II (AngII) in vitro and unilateral ureteral obstruction in vivo.	Quercetin	14-23	angiotensinogen	Homo sapiens	62-76
32702447-5	2020	We found that quercetin attenuated RTEC senescence induced by angiotensin II (AngII) in vitro and unilateral ureteral obstruction in vivo.	Quercetin	14-23	angiotensinogen	Homo sapiens	78-83
32702447-8	2020	Furthermore, quercetin enhanced mitophagy in AngII-treated RTECs, which was markedly reduced by treatment with mitophagy-specific inhibitors.	Quercetin	13-22	angiotensinogen	Homo sapiens	45-50
32702447-9	2020	Sirtuin-1 (SIRT1) was involved in quercetin-mediated PTEN-induced kinase 1 (PINK1)/Parkin-associated mitophagy activation.	Quercetin	34-43	sirtuin 1	Homo sapiens	0-9
32702447-9	2020	Sirtuin-1 (SIRT1) was involved in quercetin-mediated PTEN-induced kinase 1 (PINK1)/Parkin-associated mitophagy activation.	Quercetin	34-43	sirtuin 1	Homo sapiens	11-16
32702447-9	2020	Sirtuin-1 (SIRT1) was involved in quercetin-mediated PTEN-induced kinase 1 (PINK1)/Parkin-associated mitophagy activation.	Quercetin	34-43	PTEN induced kinase 1	Homo sapiens	53-74
32702447-9	2020	Sirtuin-1 (SIRT1) was involved in quercetin-mediated PTEN-induced kinase 1 (PINK1)/Parkin-associated mitophagy activation.	Quercetin	34-43	PTEN induced kinase 1	Homo sapiens	76-81
32702447-10	2020	Pharmacological antagonism of SIRT1 in AngII-treated RTECs blocked the effects of quercetin on mitophagy and cellular senescence.	Quercetin	82-91	sirtuin 1	Homo sapiens	30-35
32702447-10	2020	Pharmacological antagonism of SIRT1 in AngII-treated RTECs blocked the effects of quercetin on mitophagy and cellular senescence.	Quercetin	82-91	angiotensinogen	Homo sapiens	39-44
32702447-12	2020	Collectively, the antifibrotic effect of quercetin involved inhibition of RTEC senescence, possibly through activation of SIRT1/PINK1/Parkin-mediated mitophagy.	Quercetin	41-50	sirtuin 1	Homo sapiens	122-127
32702447-12	2020	Collectively, the antifibrotic effect of quercetin involved inhibition of RTEC senescence, possibly through activation of SIRT1/PINK1/Parkin-mediated mitophagy.	Quercetin	41-50	PTEN induced kinase 1	Homo sapiens	128-133
32899435-5	2020	Quercetin was shown to inhibit RANKL-mediated osteoclastogenesis, osteoblast apoptosis, oxidative stress and inflammatory response while promoting osteogenesis, angiogenesis, antioxidant expression, adipocyte apoptosis and osteoclast apoptosis.	Quercetin	0-9	TNF superfamily member 11	Homo sapiens	31-36
32932805-5	2020	Quercetin significantly decreased the hepatic and plasmatic levels of inflammatory cytokines IL-1beta, IL-6, TNF-alpha, inducible nitric oxide synthase, cyclooxygenase-2 and intercellular adhesion molecule-1-provoked by over-exercise.	Quercetin	0-9	interleukin 1 alpha	Mus musculus	93-101
32932805-5	2020	Quercetin significantly decreased the hepatic and plasmatic levels of inflammatory cytokines IL-1beta, IL-6, TNF-alpha, inducible nitric oxide synthase, cyclooxygenase-2 and intercellular adhesion molecule-1-provoked by over-exercise.	Quercetin	0-9	interleukin 6	Mus musculus	103-107
32932805-5	2020	Quercetin significantly decreased the hepatic and plasmatic levels of inflammatory cytokines IL-1beta, IL-6, TNF-alpha, inducible nitric oxide synthase, cyclooxygenase-2 and intercellular adhesion molecule-1-provoked by over-exercise.	Quercetin	0-9	tumor necrosis factor	Mus musculus	109-118
32900356-11	2021	In different doses of quercetin groups (2 mumol/L, 4 mumol/L and 8 mumol/L), the phosphorylation of mTOR and Akt were decreased and AQP1 in membrane was changed compared with high glucose group (P<0.01).	Quercetin	22-31	mechanistic target of rapamycin kinase	Homo sapiens	100-104
32900356-11	2021	In different doses of quercetin groups (2 mumol/L, 4 mumol/L and 8 mumol/L), the phosphorylation of mTOR and Akt were decreased and AQP1 in membrane was changed compared with high glucose group (P<0.01).	Quercetin	22-31	AKT serine/threonine kinase 1	Homo sapiens	109-112
32900356-11	2021	In different doses of quercetin groups (2 mumol/L, 4 mumol/L and 8 mumol/L), the phosphorylation of mTOR and Akt were decreased and AQP1 in membrane was changed compared with high glucose group (P<0.01).	Quercetin	22-31	aquaporin 1 (Colton blood group)	Homo sapiens	132-136
32900356-12	2021	CONCLUSION: Quercetin significantly decreased the AQP1 elevation and prevented the change of AQP1 location through inhibiting the activation of the PI3K/Akt/mTOR signaling in high-glucose-cultured SRA01/04 cells, which might have the preventable and inhibitory effects on the early development of diabetic cataract.	Quercetin	12-21	aquaporin 1 (Colton blood group)	Homo sapiens	50-54
32900356-12	2021	CONCLUSION: Quercetin significantly decreased the AQP1 elevation and prevented the change of AQP1 location through inhibiting the activation of the PI3K/Akt/mTOR signaling in high-glucose-cultured SRA01/04 cells, which might have the preventable and inhibitory effects on the early development of diabetic cataract.	Quercetin	12-21	aquaporin 1 (Colton blood group)	Homo sapiens	93-97
32900356-12	2021	CONCLUSION: Quercetin significantly decreased the AQP1 elevation and prevented the change of AQP1 location through inhibiting the activation of the PI3K/Akt/mTOR signaling in high-glucose-cultured SRA01/04 cells, which might have the preventable and inhibitory effects on the early development of diabetic cataract.	Quercetin	12-21	AKT serine/threonine kinase 1	Homo sapiens	153-156
32900356-12	2021	CONCLUSION: Quercetin significantly decreased the AQP1 elevation and prevented the change of AQP1 location through inhibiting the activation of the PI3K/Akt/mTOR signaling in high-glucose-cultured SRA01/04 cells, which might have the preventable and inhibitory effects on the early development of diabetic cataract.	Quercetin	12-21	mechanistic target of rapamycin kinase	Homo sapiens	157-161
32553736-0	2020	Quercetin attenuates diabetic neuropathic pain by inhibiting mTOR/p70S6K pathway-mediated changes of synaptic morphology and synaptic protein levels in spinal dorsal horn of db/db mice.	Quercetin	0-9	mechanistic target of rapamycin kinase	Mus musculus	61-65
32553736-0	2020	Quercetin attenuates diabetic neuropathic pain by inhibiting mTOR/p70S6K pathway-mediated changes of synaptic morphology and synaptic protein levels in spinal dorsal horn of db/db mice.	Quercetin	0-9	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	66-72
32553736-7	2020	Meanwhile, the up-regulated expressions of synaptic plasticity-associated proteins postsynaptic density protein 95 (PSD-95) and synaptophysin in spinal dorsal horn of db/db mice were decreased by quercetin treatment.	Quercetin	196-205	discs large MAGUK scaffold protein 4	Mus musculus	83-114
32553736-7	2020	Meanwhile, the up-regulated expressions of synaptic plasticity-associated proteins postsynaptic density protein 95 (PSD-95) and synaptophysin in spinal dorsal horn of db/db mice were decreased by quercetin treatment.	Quercetin	196-205	discs large MAGUK scaffold protein 4	Mus musculus	116-122
32553736-7	2020	Meanwhile, the up-regulated expressions of synaptic plasticity-associated proteins postsynaptic density protein 95 (PSD-95) and synaptophysin in spinal dorsal horn of db/db mice were decreased by quercetin treatment.	Quercetin	196-205	synaptophysin	Mus musculus	128-141
32553736-8	2020	In addition, quercetin treatment reduced the phosphorylated levels of mammalian target of rapamycin (mTOR) and p70 ribosomal S6 kinase (p70S6K) in spinal dorsal horn of db/db mice.	Quercetin	13-22	mechanistic target of rapamycin kinase	Homo sapiens	70-99
32553736-8	2020	In addition, quercetin treatment reduced the phosphorylated levels of mammalian target of rapamycin (mTOR) and p70 ribosomal S6 kinase (p70S6K) in spinal dorsal horn of db/db mice.	Quercetin	13-22	mechanistic target of rapamycin kinase	Homo sapiens	101-105
32553736-8	2020	In addition, quercetin treatment reduced the phosphorylated levels of mammalian target of rapamycin (mTOR) and p70 ribosomal S6 kinase (p70S6K) in spinal dorsal horn of db/db mice.	Quercetin	13-22	ribosomal protein S6 kinase B1	Homo sapiens	111-134
32553736-8	2020	In addition, quercetin treatment reduced the phosphorylated levels of mammalian target of rapamycin (mTOR) and p70 ribosomal S6 kinase (p70S6K) in spinal dorsal horn of db/db mice.	Quercetin	13-22	ribosomal protein S6 kinase B1	Homo sapiens	136-142
32553736-9	2020	These results demonstrate that quercetin may alleviate diabetic neuropathic pain by inhibiting mTOR/p70S6K pathway-mediated changes of synaptic morphology and synaptic protein levels in spinal dorsal horn neurons of db/db mice.	Quercetin	31-40	mechanistic target of rapamycin kinase	Mus musculus	95-99
32553736-9	2020	These results demonstrate that quercetin may alleviate diabetic neuropathic pain by inhibiting mTOR/p70S6K pathway-mediated changes of synaptic morphology and synaptic protein levels in spinal dorsal horn neurons of db/db mice.	Quercetin	31-40	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	100-106
32932805-5	2020	Quercetin significantly decreased the hepatic and plasmatic levels of inflammatory cytokines IL-1beta, IL-6, TNF-alpha, inducible nitric oxide synthase, cyclooxygenase-2 and intercellular adhesion molecule-1-provoked by over-exercise.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	120-151
32932805-5	2020	Quercetin significantly decreased the hepatic and plasmatic levels of inflammatory cytokines IL-1beta, IL-6, TNF-alpha, inducible nitric oxide synthase, cyclooxygenase-2 and intercellular adhesion molecule-1-provoked by over-exercise.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	153-169
32932805-5	2020	Quercetin significantly decreased the hepatic and plasmatic levels of inflammatory cytokines IL-1beta, IL-6, TNF-alpha, inducible nitric oxide synthase, cyclooxygenase-2 and intercellular adhesion molecule-1-provoked by over-exercise.	Quercetin	0-9	intercellular adhesion molecule 1	Mus musculus	174-207
32932805-6	2020	Furthermore, diminished activation and nuclear translocation of NF-kappaB were found after quercetin treatment through inhibiting IKKalpha and Ikappabalpha phosphorylation of intensive running mice.	Quercetin	91-100	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	64-73
32932805-6	2020	Furthermore, diminished activation and nuclear translocation of NF-kappaB were found after quercetin treatment through inhibiting IKKalpha and Ikappabalpha phosphorylation of intensive running mice.	Quercetin	91-100	conserved helix-loop-helix ubiquitous kinase	Mus musculus	130-138
32932805-6	2020	Furthermore, diminished activation and nuclear translocation of NF-kappaB were found after quercetin treatment through inhibiting IKKalpha and Ikappabalpha phosphorylation of intensive running mice.	Quercetin	91-100	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	143-155
32900356-0	2021	Quercetin inhibits AQP1 translocation in high-glucose-cultured SRA01/04 cells through PI3K/Akt/mTOR Pathway.	Quercetin	0-9	aquaporin 1 (Colton blood group)	Homo sapiens	19-23
32900356-0	2021	Quercetin inhibits AQP1 translocation in high-glucose-cultured SRA01/04 cells through PI3K/Akt/mTOR Pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	91-94
32900356-0	2021	Quercetin inhibits AQP1 translocation in high-glucose-cultured SRA01/04 cells through PI3K/Akt/mTOR Pathway.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	95-99
32900356-1	2021	OBJECTIVE: To investigate the quercetin"s effects on Aquaporin 1 (AQP1) translocation in condition of high glucose and try to clarify the underlying mechanisms and provide new ideas for the treatment of diabetic cataract (DC).	Quercetin	30-39	aquaporin 1 (Colton blood group)	Homo sapiens	53-64
32900356-1	2021	OBJECTIVE: To investigate the quercetin"s effects on Aquaporin 1 (AQP1) translocation in condition of high glucose and try to clarify the underlying mechanisms and provide new ideas for the treatment of diabetic cataract (DC).	Quercetin	30-39	aquaporin 1 (Colton blood group)	Homo sapiens	66-70
32900356-7	2021	The effect of quercetin on the expression of AQP1 and PI3K/Akt/mTOR signaling was detected.	Quercetin	14-23	aquaporin 1 (Colton blood group)	Homo sapiens	45-49
32900356-7	2021	The effect of quercetin on the expression of AQP1 and PI3K/Akt/mTOR signaling was detected.	Quercetin	14-23	AKT serine/threonine kinase 1	Homo sapiens	59-62
32900356-7	2021	The effect of quercetin on the expression of AQP1 and PI3K/Akt/mTOR signaling was detected.	Quercetin	14-23	mechanistic target of rapamycin kinase	Homo sapiens	63-67
32906729-11	2020	The flavonoids fisetin and quercetin were active in restoring ERK phosphorylation, as well as sensitivity to platinum compounds.	Quercetin	27-36	mitogen-activated protein kinase 1	Homo sapiens	62-65
32892319-8	2021	The enzyme activity of GST was significantly less in Cr-treated animals of both generations and this effect was significantly reversed on cotreatment with quercetin.	Quercetin	155-164	hematopoietic prostaglandin D synthase	Mus musculus	23-26
32892319-10	2021	However, catalase activity did not show significant decrease with Cr but cotreatment with quercetin resulted in significant decrease compared with control and this effect was not matched by its gene expression.	Quercetin	90-99	catalase	Mus musculus	9-17
32881908-0	2020	Quercetin enhances motility in aged and heat-stressed Caenorhabditis elegans nematodes by modulating both HSF-1 activity, and insulin-like and p38-MAPK signalling.	Quercetin	0-9	Heat shock transcription factor hsf-1	Caenorhabditis elegans	106-111
32881908-4	2020	In particular, the transcription factors DAF-16 and SKN-1 were found to mediate the observed quercetin-induced effects, consistent with their previously demonstrated roles as regulators of aging.	Quercetin	93-102	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	41-47
32881908-4	2020	In particular, the transcription factors DAF-16 and SKN-1 were found to mediate the observed quercetin-induced effects, consistent with their previously demonstrated roles as regulators of aging.	Quercetin	93-102	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	52-57
32881908-5	2020	Furthermore, we demonstrated, for the first time, that quercetin induced heat-stress tolerance in C. elegans by modulating HSF-1 expression and/or activity.	Quercetin	55-64	Heat shock transcription factor hsf-1	Caenorhabditis elegans	123-128
32474374-1	2020	Considering the antioxidant, neuroprotective, inflammatory and nitric oxide modulatory actions of quercetin, the aim of this study was to test the effect of quercetin administration in drinking water (40 mg/day/rat) on neuronal nitric oxide synthase (nNOS), vasoactive intestinal peptide (VIP), overall population of myenteric neurons (HuC/D) and nitric oxide (NO) levels in the jejunal samples from diabetic rats.	Quercetin	157-166	nitric oxide synthase 1	Rattus norvegicus	219-249
32474374-7	2020	In conclusion, the results showed that quercetin supplementation increased the bioavailability of NO in the jejunum in euglycemic and mitigate the effects of diabetes on nNOS-IR neurons and VIP-IR varicosities in the myenteric plexus of diabetic rats.	Quercetin	39-48	nitric oxide synthase 1	Rattus norvegicus	170-174
32474374-7	2020	In conclusion, the results showed that quercetin supplementation increased the bioavailability of NO in the jejunum in euglycemic and mitigate the effects of diabetes on nNOS-IR neurons and VIP-IR varicosities in the myenteric plexus of diabetic rats.	Quercetin	39-48	vasoactive intestinal peptide	Rattus norvegicus	190-193
32681548-4	2020	We showed that combination of exercise training and Quercetin supplementation resulted in the significant improvement in depressive-live behaviors and decrease in tumor incidence through modulation of BDNF/ TrKbeta /beta-catenin axis in the prefrontal cortex.	Quercetin	52-61	brain-derived neurotrophic factor	Rattus norvegicus	201-205
32739480-4	2020	All compounds were determined as promising AR inhibitors with the Ki values in the range of 0.018 +- 0.005 muM-3.746 +- 1.321 muM compared to the quercetin (Ki = 7.025 +- 1.780 muM).	Quercetin	146-155	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	43-45
32681548-4	2020	We showed that combination of exercise training and Quercetin supplementation resulted in the significant improvement in depressive-live behaviors and decrease in tumor incidence through modulation of BDNF/ TrKbeta /beta-catenin axis in the prefrontal cortex.	Quercetin	52-61	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	207-214
32681548-4	2020	We showed that combination of exercise training and Quercetin supplementation resulted in the significant improvement in depressive-live behaviors and decrease in tumor incidence through modulation of BDNF/ TrKbeta /beta-catenin axis in the prefrontal cortex.	Quercetin	52-61	catenin beta 1	Rattus norvegicus	216-228
32681548-14	2020	Taken together, our results showed that quercetin and exercise training exerts potent anti-tumor and anti-depressive effects through suppressing inflammation and upregulation of BDNF/ TrKbeta /beta-catenin axis in the prefrontal cortex.	Quercetin	40-49	brain-derived neurotrophic factor	Rattus norvegicus	178-182
32681548-14	2020	Taken together, our results showed that quercetin and exercise training exerts potent anti-tumor and anti-depressive effects through suppressing inflammation and upregulation of BDNF/ TrKbeta /beta-catenin axis in the prefrontal cortex.	Quercetin	40-49	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	184-191
32681548-14	2020	Taken together, our results showed that quercetin and exercise training exerts potent anti-tumor and anti-depressive effects through suppressing inflammation and upregulation of BDNF/ TrKbeta /beta-catenin axis in the prefrontal cortex.	Quercetin	40-49	catenin beta 1	Rattus norvegicus	193-205
32599520-4	2020	Oral pretreatment using quercetin has alleviated cerebral I/R-induced neurological deficits, brain infarction, blood-brain barrier disruption, oxidative stress, TNF-alpha and IL-1beta mRNA expression, along with apoptotic caspase 3 activity.	Quercetin	24-33	tumor necrosis factor	Rattus norvegicus	161-170
32599520-4	2020	Oral pretreatment using quercetin has alleviated cerebral I/R-induced neurological deficits, brain infarction, blood-brain barrier disruption, oxidative stress, TNF-alpha and IL-1beta mRNA expression, along with apoptotic caspase 3 activity.	Quercetin	24-33	interleukin 1 alpha	Rattus norvegicus	175-183
32599520-4	2020	Oral pretreatment using quercetin has alleviated cerebral I/R-induced neurological deficits, brain infarction, blood-brain barrier disruption, oxidative stress, TNF-alpha and IL-1beta mRNA expression, along with apoptotic caspase 3 activity.	Quercetin	24-33	caspase 3	Rattus norvegicus	222-231
32599520-7	2020	Quercetin alleviated the changes in ERK/Akt phosphorylation and protein phosphatase activities.	Quercetin	0-9	Eph receptor B1	Rattus norvegicus	36-39
32599520-7	2020	Quercetin alleviated the changes in ERK/Akt phosphorylation and protein phosphatase activities.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
32599520-9	2020	Taken together, our results demonstrate that quercetin alleviated the increment of protein tyrosine and serine/threonine phosphatase activity, along with the reduction of ERK and Akt phosphorylation, which may play pivotal roles in the expansion of brain injury after cerebral I/R.	Quercetin	45-54	Eph receptor B1	Rattus norvegicus	171-174
32599520-9	2020	Taken together, our results demonstrate that quercetin alleviated the increment of protein tyrosine and serine/threonine phosphatase activity, along with the reduction of ERK and Akt phosphorylation, which may play pivotal roles in the expansion of brain injury after cerebral I/R.	Quercetin	45-54	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
32830144-6	2020	In HepG2 cells, paeonol, quercetin, beta-sitosterol, and gallic acid play a defensive role against H2O2-induced oxidative stress through activating Nrf2/Keap1 pathway, indicating that these monomers have anti-oxidative properties.	Quercetin	25-34	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
33041510-0	2020	Quercetin induced NUPR1-dependent autophagic cell death by disturbing reactive oxygen species homeostasis in osteosarcoma cells.	Quercetin	0-9	nuclear protein 1, transcriptional regulator	Homo sapiens	18-23
33041510-5	2020	In this study, we exposed MG-63 cells to different concentrations of quercetin (50, 100 and 200 microM) for 24 h. Here, we show that quercetin increased autophagic flux in the MG-63 cells, as evidenced by the upregulation of LC3B-II/LC3B-I and downregulation of P62/SQSTM1.	Quercetin	69-78	microtubule associated protein 1 light chain 3 beta	Homo sapiens	225-229
33041510-5	2020	In this study, we exposed MG-63 cells to different concentrations of quercetin (50, 100 and 200 microM) for 24 h. Here, we show that quercetin increased autophagic flux in the MG-63 cells, as evidenced by the upregulation of LC3B-II/LC3B-I and downregulation of P62/SQSTM1.	Quercetin	69-78	sequestosome 1	Homo sapiens	262-265
33041510-5	2020	In this study, we exposed MG-63 cells to different concentrations of quercetin (50, 100 and 200 microM) for 24 h. Here, we show that quercetin increased autophagic flux in the MG-63 cells, as evidenced by the upregulation of LC3B-II/LC3B-I and downregulation of P62/SQSTM1.	Quercetin	69-78	sequestosome 1	Homo sapiens	266-272
33041510-5	2020	In this study, we exposed MG-63 cells to different concentrations of quercetin (50, 100 and 200 microM) for 24 h. Here, we show that quercetin increased autophagic flux in the MG-63 cells, as evidenced by the upregulation of LC3B-II/LC3B-I and downregulation of P62/SQSTM1.	Quercetin	133-142	microtubule associated protein 1 light chain 3 beta	Homo sapiens	225-229
33041510-5	2020	In this study, we exposed MG-63 cells to different concentrations of quercetin (50, 100 and 200 microM) for 24 h. Here, we show that quercetin increased autophagic flux in the MG-63 cells, as evidenced by the upregulation of LC3B-II/LC3B-I and downregulation of P62/SQSTM1.	Quercetin	133-142	sequestosome 1	Homo sapiens	262-265
33041510-5	2020	In this study, we exposed MG-63 cells to different concentrations of quercetin (50, 100 and 200 microM) for 24 h. Here, we show that quercetin increased autophagic flux in the MG-63 cells, as evidenced by the upregulation of LC3B-II/LC3B-I and downregulation of P62/SQSTM1.	Quercetin	133-142	sequestosome 1	Homo sapiens	266-272
33041510-6	2020	Moreover, the autophagy inhibitor Bafilomycin A1 or genetic blocking autophagy with ATG5 knockdown decreased quercetin-induced cell death, indicating quercetin triggered autophagic cell death in MG-63 cells.	Quercetin	109-118	autophagy related 5	Homo sapiens	84-88
33041510-6	2020	Moreover, the autophagy inhibitor Bafilomycin A1 or genetic blocking autophagy with ATG5 knockdown decreased quercetin-induced cell death, indicating quercetin triggered autophagic cell death in MG-63 cells.	Quercetin	150-159	autophagy related 5	Homo sapiens	84-88
33041510-7	2020	Specifically, quercetin increased NUPR1 expression and activated of NUPR1 reporter activity, which contributed to the expression of autophagy-related genes and subsequent initiated autophagic cell death in osteosarcoma cells.	Quercetin	14-23	nuclear protein 1, transcriptional regulator	Homo sapiens	34-39
33041510-7	2020	Specifically, quercetin increased NUPR1 expression and activated of NUPR1 reporter activity, which contributed to the expression of autophagy-related genes and subsequent initiated autophagic cell death in osteosarcoma cells.	Quercetin	14-23	nuclear protein 1, transcriptional regulator	Homo sapiens	68-73
33041510-9	2020	Finally, NAC also abolished quercetin-induced autophagic cell death in vivo.	Quercetin	28-37	X-linked Kx blood group	Homo sapiens	9-12
32394448-3	2020	Therefore, in this work, we have evaluated the protective effect of quercetin under non restriction (NR) and CR conditions on the sensitivity of Saccharomyces cerevisiae mutant strains (sod1 , sod2 , cta1 , ctt1 , tsa1  and glr1 ) deficient in antioxidant defence systems (superoxide dismutase, catalase, thioredoxin peroxidase and glutathione reductase) against H2 O2 -induced oxidative stress.	Quercetin	68-77	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	186-190
32394448-3	2020	Therefore, in this work, we have evaluated the protective effect of quercetin under non restriction (NR) and CR conditions on the sensitivity of Saccharomyces cerevisiae mutant strains (sod1 , sod2 , cta1 , ctt1 , tsa1  and glr1 ) deficient in antioxidant defence systems (superoxide dismutase, catalase, thioredoxin peroxidase and glutathione reductase) against H2 O2 -induced oxidative stress.	Quercetin	68-77	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	193-197
33041510-10	2020	Taken together, these data demonstrate that quercetin induces osteosarcoma cell death via inducing excessive autophagy, which is mediated through the ROS-NUPR1 pathway.	Quercetin	44-53	nuclear protein 1, transcriptional regulator	Homo sapiens	154-159
32394448-3	2020	Therefore, in this work, we have evaluated the protective effect of quercetin under non restriction (NR) and CR conditions on the sensitivity of Saccharomyces cerevisiae mutant strains (sod1 , sod2 , cta1 , ctt1 , tsa1  and glr1 ) deficient in antioxidant defence systems (superoxide dismutase, catalase, thioredoxin peroxidase and glutathione reductase) against H2 O2 -induced oxidative stress.	Quercetin	68-77	catalase T	Saccharomyces cerevisiae S288C	207-211
32830144-6	2020	In HepG2 cells, paeonol, quercetin, beta-sitosterol, and gallic acid play a defensive role against H2O2-induced oxidative stress through activating Nrf2/Keap1 pathway, indicating that these monomers have anti-oxidative properties.	Quercetin	25-34	kelch like ECH associated protein 1	Homo sapiens	153-158
32388479-2	2020	Quercetin and certain other planar flavones/flavonols can inhibit CK2 in high nanomolar concentrations; this may explain quercetin"s ability to slow the proliferation of RNA viruses in cell cultures and in mice.	Quercetin	0-9	casein kinase 2, alpha prime polypeptide	Mus musculus	66-69
32994029-0	2020	LHRH-conjugated, PEGylated, poly-lactide-co-glycolide nanocapsules for targeted delivery of combinational chemotherapeutic drugs Docetaxel and Quercetin for prostate cancer.	Quercetin	143-152	gonadotropin releasing hormone 1	Homo sapiens	0-4
32388479-2	2020	Quercetin and certain other planar flavones/flavonols can inhibit CK2 in high nanomolar concentrations; this may explain quercetin"s ability to slow the proliferation of RNA viruses in cell cultures and in mice.	Quercetin	121-130	casein kinase 2, alpha prime polypeptide	Mus musculus	66-69
32388479-4	2020	Quercetin and enzymatically-modified isoquercitrin (EMIQ - a food additive/nutraceutical that upon oral administration achieves far higher plasma concentrations of quercetin than quercetin per se) also have exerted a range of vascular-protective effects clinically and in rodents - improving endothelial function, warding off atherosclerosis, lowering blood pressure, decreasing C-reactive protein, aiding glycemic control, stabilizing platelets - that might also, at least in part, reflect CK2 inhibition.	Quercetin	0-9	C-reactive protein	Homo sapiens	379-397
32388479-4	2020	Quercetin and enzymatically-modified isoquercitrin (EMIQ - a food additive/nutraceutical that upon oral administration achieves far higher plasma concentrations of quercetin than quercetin per se) also have exerted a range of vascular-protective effects clinically and in rodents - improving endothelial function, warding off atherosclerosis, lowering blood pressure, decreasing C-reactive protein, aiding glycemic control, stabilizing platelets - that might also, at least in part, reflect CK2 inhibition.	Quercetin	0-9	casein kinase 2, alpha prime polypeptide	Mus musculus	491-494
32736726-0	2020	Masking quercetin: A simple strategy for selective detection of rutin by combination of bovine serum albumin and fluorescent silicon nanoparticles.	Quercetin	8-17	albumin	Homo sapiens	95-108
32705181-5	2020	Based on the finding that QUE inhibited the phosphorylation of ERK protein expression in LPS-induced RAW264.7 cells, it was confirmed that inhibition of inflammatory responses by QUE was mediated via the ERK pathway.	Quercetin	26-29	mitogen-activated protein kinase 1	Mus musculus	63-66
32705181-5	2020	Based on the finding that QUE inhibited the phosphorylation of ERK protein expression in LPS-induced RAW264.7 cells, it was confirmed that inhibition of inflammatory responses by QUE was mediated via the ERK pathway.	Quercetin	26-29	mitogen-activated protein kinase 1	Mus musculus	204-207
32922227-0	2020	Manipulation of Quercetin and Melatonin in the Down-Regulation of HIF-1alpha, HSP-70 and VEGF Pathways in Rat"s Kidneys Induced by Hypoxic Stress.	Quercetin	16-25	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	66-76
32922227-0	2020	Manipulation of Quercetin and Melatonin in the Down-Regulation of HIF-1alpha, HSP-70 and VEGF Pathways in Rat"s Kidneys Induced by Hypoxic Stress.	Quercetin	16-25	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	78-84
32922227-0	2020	Manipulation of Quercetin and Melatonin in the Down-Regulation of HIF-1alpha, HSP-70 and VEGF Pathways in Rat"s Kidneys Induced by Hypoxic Stress.	Quercetin	16-25	vascular endothelial growth factor A	Rattus norvegicus	89-93
32908632-7	2020	The network analysis showed that the QX1 active components quercetin, formononetin, kaempferol, taxifolin, cryptotanshinone, and tanshinone IIA had a good binding activity with screened targets.	Quercetin	59-68	ATPase, class II, type 9A	Mus musculus	140-143
32908926-0	2020	Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1alpha/VEGF Signaling-Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	24-40
32817626-0	2020	Quercetin negatively regulates IL-1beta production in Pseudomonas aeruginosa-infected human macrophages through the inhibition of MAPK/NLRP3 inflammasome pathways.	Quercetin	0-9	NLR family pyrin domain containing 3	Homo sapiens	135-140
32908926-0	2020	Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1alpha/VEGF Signaling-Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm.	Quercetin	0-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	56-66
32908926-8	2020	Accordingly, quercetin decreased the expression of proangiogenic mediators, including VEGF-A, intercellular adhesion molecule-1, vascular cell adhesion molecule 1, and vascular endothelial cadherin.	Quercetin	13-22	vascular endothelial growth factor A	Mus musculus	86-92
32908926-8	2020	Accordingly, quercetin decreased the expression of proangiogenic mediators, including VEGF-A, intercellular adhesion molecule-1, vascular cell adhesion molecule 1, and vascular endothelial cadherin.	Quercetin	13-22	intercellular adhesion molecule 1	Mus musculus	94-127
32908926-8	2020	Accordingly, quercetin decreased the expression of proangiogenic mediators, including VEGF-A, intercellular adhesion molecule-1, vascular cell adhesion molecule 1, and vascular endothelial cadherin.	Quercetin	13-22	vascular cell adhesion molecule 1	Mus musculus	129-162
32908926-8	2020	Accordingly, quercetin decreased the expression of proangiogenic mediators, including VEGF-A, intercellular adhesion molecule-1, vascular cell adhesion molecule 1, and vascular endothelial cadherin.	Quercetin	13-22	cadherin 5	Mus musculus	168-197
32908926-9	2020	Quercetin treatment also inhibited the expression of COX-2 and hypoxia-inducible factor 1alpha (HIF-1alpha).	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	53-58
32908926-9	2020	Quercetin treatment also inhibited the expression of COX-2 and hypoxia-inducible factor 1alpha (HIF-1alpha).	Quercetin	0-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	63-94
32908926-9	2020	Quercetin treatment also inhibited the expression of COX-2 and hypoxia-inducible factor 1alpha (HIF-1alpha).	Quercetin	0-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	96-106
32908926-10	2020	It was also found that quercetin-3-glucuronide, a major quercetin metabolite, downregulated the expression of COX-2, HIF-1alpha, VEGF-A, and matrix metalloproteinase activities in aortic vascular smooth muscle cells isolated from AAA mice.	Quercetin	23-32	prostaglandin-endoperoxide synthase 2	Mus musculus	110-115
32908926-10	2020	It was also found that quercetin-3-glucuronide, a major quercetin metabolite, downregulated the expression of COX-2, HIF-1alpha, VEGF-A, and matrix metalloproteinase activities in aortic vascular smooth muscle cells isolated from AAA mice.	Quercetin	23-32	hypoxia inducible factor 1, alpha subunit	Mus musculus	117-127
32908926-10	2020	It was also found that quercetin-3-glucuronide, a major quercetin metabolite, downregulated the expression of COX-2, HIF-1alpha, VEGF-A, and matrix metalloproteinase activities in aortic vascular smooth muscle cells isolated from AAA mice.	Quercetin	23-32	vascular endothelial growth factor A	Mus musculus	129-135
32908926-11	2020	Conclusion: Quercetin attenuates neovascularization during AAA growth, and this effect is mediated via the inhibition of COX-2, which decreases HIF-1alpha/VEGF signaling-related angiogenesis.	Quercetin	12-21	prostaglandin-endoperoxide synthase 2	Mus musculus	121-126
32908926-11	2020	Conclusion: Quercetin attenuates neovascularization during AAA growth, and this effect is mediated via the inhibition of COX-2, which decreases HIF-1alpha/VEGF signaling-related angiogenesis.	Quercetin	12-21	hypoxia inducible factor 1, alpha subunit	Mus musculus	144-154
32908926-11	2020	Conclusion: Quercetin attenuates neovascularization during AAA growth, and this effect is mediated via the inhibition of COX-2, which decreases HIF-1alpha/VEGF signaling-related angiogenesis.	Quercetin	12-21	vascular endothelial growth factor A	Mus musculus	155-159
32816149-0	2020	Exploring conformational changes of PPAR-Gamma complexed with novel kaempferol, quercetin, and resveratrol derivatives to understand binding mode assessment: a small-molecule checkmate to cancer therapy.	Quercetin	80-89	peroxisome proliferator activated receptor gamma	Homo sapiens	36-46
32816149-4	2020	The molecular docking experiment performed by FlexX elucidated the efficacy of derivatives; Kem204, Qur8, and Res183 of kaempferol, quercetin, and resveratrol respectively to be more effective against PPAR-gamma as compared with other derivatives.	Quercetin	132-141	peroxisome proliferator activated receptor gamma	Homo sapiens	201-211
32817626-9	2020	Moreover, quercetin reduced the NLRP3 expression and inhibited the P. aeruginosa-mediated cleavage of caspase-1 as well as mature IL-1beta.	Quercetin	10-19	NLR family pyrin domain containing 3	Homo sapiens	32-37
32817626-10	2020	These results thus indicated that quercetin inhibition of P. aeruginosa-induced IL-1beta production is mediated by suppressing the initial priming step and by inhibiting the NLRP3 inflammasome activation.	Quercetin	34-43	NLR family pyrin domain containing 3	Homo sapiens	174-179
32807146-8	2020	Mechanistically, quercetin could inhibit the mRNA and protein expression level of SREBP2 and HMGCR with or without LDL treatment.	Quercetin	17-26	sterol regulatory element binding transcription factor 2	Rattus norvegicus	82-88
32807146-8	2020	Mechanistically, quercetin could inhibit the mRNA and protein expression level of SREBP2 and HMGCR with or without LDL treatment.	Quercetin	17-26	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	93-98
32807146-9	2020	In addition, quercetin could also reduce the LXRbeta while induced SR-BI mRNA expression.	Quercetin	13-22	scavenger receptor class B, member 1	Rattus norvegicus	67-72
32761338-0	2020	Combination of Quercetin, Hirudin and Cinnamaldehyde Promotes Schwann Cell Differentiation and Myelination against High Glucose by Inhibiting ERK Signaling Pathway.	Quercetin	15-24	mitogen-activated protein kinase 1	Homo sapiens	142-145
32407724-8	2020	We observed quercetin nanoparticles (0.03%) treatment caused marked reduction in the tumor necrosis factor-alpha, whereas expressions of interleukin 10, vascular endothelial growth factor and transforming growth factor beta1 was increased significantly with treatment.	Quercetin	12-21	tumor necrosis factor	Rattus norvegicus	85-112
32758232-0	2020	Quercetin attenuates reduced uterine perfusion pressure -induced hypertension in pregnant rats through regulation of endothelin-1 and endothelin-1 type A receptor.	Quercetin	0-9	endothelin 1	Rattus norvegicus	117-129
32758232-0	2020	Quercetin attenuates reduced uterine perfusion pressure -induced hypertension in pregnant rats through regulation of endothelin-1 and endothelin-1 type A receptor.	Quercetin	0-9	endothelin receptor type A	Rattus norvegicus	134-162
32758232-9	2020	RESULTS: In RUPP induced rats, quercetin treatment decreased SBP and DBP, fetal resorptions percentage, plasma ET-1 and sFlt-1 concentrations, ET-1 and ETAR levels, but increased fetal body weight and VEGF expression.	Quercetin	31-40	endothelin 1	Rattus norvegicus	111-115
32758232-9	2020	RESULTS: In RUPP induced rats, quercetin treatment decreased SBP and DBP, fetal resorptions percentage, plasma ET-1 and sFlt-1 concentrations, ET-1 and ETAR levels, but increased fetal body weight and VEGF expression.	Quercetin	31-40	endothelin 1	Rattus norvegicus	143-147
32758232-9	2020	RESULTS: In RUPP induced rats, quercetin treatment decreased SBP and DBP, fetal resorptions percentage, plasma ET-1 and sFlt-1 concentrations, ET-1 and ETAR levels, but increased fetal body weight and VEGF expression.	Quercetin	31-40	endothelin receptor type A	Rattus norvegicus	152-156
32758232-9	2020	RESULTS: In RUPP induced rats, quercetin treatment decreased SBP and DBP, fetal resorptions percentage, plasma ET-1 and sFlt-1 concentrations, ET-1 and ETAR levels, but increased fetal body weight and VEGF expression.	Quercetin	31-40	vascular endothelial growth factor A	Rattus norvegicus	201-205
32758232-11	2020	CONCLUSION: Quercetin attenuates RUPP induced hypertension in pregnant rats through the regulation of ET-1 and ETAR.	Quercetin	12-21	endothelin 1	Rattus norvegicus	102-106
32758232-11	2020	CONCLUSION: Quercetin attenuates RUPP induced hypertension in pregnant rats through the regulation of ET-1 and ETAR.	Quercetin	12-21	endothelin receptor type A	Rattus norvegicus	111-115
32748838-10	2020	Based on PCR array, we identified decreased levels of EGFR, EGR3, and IL6, and increased levels of IGFBP7 and NKX3.1, overall supporting anti-PCa effects of quercetin-resveratrol.	Quercetin	157-166	epidermal growth factor receptor	Mus musculus	54-58
32748838-10	2020	Based on PCR array, we identified decreased levels of EGFR, EGR3, and IL6, and increased levels of IGFBP7 and NKX3.1, overall supporting anti-PCa effects of quercetin-resveratrol.	Quercetin	157-166	early growth response 3	Mus musculus	60-64
32748838-10	2020	Based on PCR array, we identified decreased levels of EGFR, EGR3, and IL6, and increased levels of IGFBP7 and NKX3.1, overall supporting anti-PCa effects of quercetin-resveratrol.	Quercetin	157-166	interleukin 6	Mus musculus	70-73
32748838-10	2020	Based on PCR array, we identified decreased levels of EGFR, EGR3, and IL6, and increased levels of IGFBP7 and NKX3.1, overall supporting anti-PCa effects of quercetin-resveratrol.	Quercetin	157-166	insulin-like growth factor binding protein 7	Mus musculus	99-105
32748838-10	2020	Based on PCR array, we identified decreased levels of EGFR, EGR3, and IL6, and increased levels of IGFBP7 and NKX3.1, overall supporting anti-PCa effects of quercetin-resveratrol.	Quercetin	157-166	NK3 homeobox 1	Mus musculus	110-116
32799543-9	2020	Quercetin-induced apoptosis was confirmed by flow cytometry analysis of Annexin V+ cells.	Quercetin	0-9	annexin A5	Mus musculus	72-81
32593613-2	2020	In silico modelling has identified several natural products including quercetin as potential highly effective disruptors of the initial infection process involving binding to the interface between the SARS-CoV-2 (Covid-19) Viral Spike Protein and the epithelial cell Angiotensin Converting Enzyme-2 (ACE2) protein.	Quercetin	70-79	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	229-234
32593613-2	2020	In silico modelling has identified several natural products including quercetin as potential highly effective disruptors of the initial infection process involving binding to the interface between the SARS-CoV-2 (Covid-19) Viral Spike Protein and the epithelial cell Angiotensin Converting Enzyme-2 (ACE2) protein.	Quercetin	70-79	angiotensin converting enzyme 2	Homo sapiens	267-298
32593613-2	2020	In silico modelling has identified several natural products including quercetin as potential highly effective disruptors of the initial infection process involving binding to the interface between the SARS-CoV-2 (Covid-19) Viral Spike Protein and the epithelial cell Angiotensin Converting Enzyme-2 (ACE2) protein.	Quercetin	70-79	angiotensin converting enzyme 2	Homo sapiens	300-304
32422185-2	2020	The natural flavonoid Quercetin (Que) has been reported to be able to inhibit P-gp-mediated MDR in various cancer cells.	Quercetin	22-31	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
32422185-2	2020	The natural flavonoid Quercetin (Que) has been reported to be able to inhibit P-gp-mediated MDR in various cancer cells.	Quercetin	22-25	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
32422185-5	2020	Our present results showed that 33 muM of Que significantly improved the cytotoxicity of doxorubicin (Dox) to P-gp-overexpressed SW620/Ad300 cells by proliferation and apoptpsis assay.	Quercetin	42-45	ATP binding cassette subfamily B member 1	Homo sapiens	110-114
32422185-6	2020	Further mechanism studies demonstrated that Que inhibited the ATP-driven transport activity of P-gp, which in turn increased the intracellular accumulation of Dox.	Quercetin	44-47	ATP binding cassette subfamily B member 1	Homo sapiens	95-99
32785199-0	2020	Indomethacin Increases Quercetin Affinity for Human Serum Albumin: A Combined Experimental and Computational Study and Its Broader Implications.	Quercetin	23-32	albumin	Homo sapiens	58-65
32848804-8	2020	This review will examine compounds of natural origin recently found to upregulate SIRT1 activity, such as polyphenolic products in fruits, vegetables, and plants including resveratrol, fisetin, quercetin, and curcumin.	Quercetin	194-203	sirtuin 1	Homo sapiens	82-87
33728016-12	2020	Using annexin-V/FITC staining technique, the quercetin/doxorubicin combination showed a significantly lower percent of apoptotic cells compared to doxorubicin alone treated cells.	Quercetin	45-54	annexin A5	Homo sapiens	6-15
32748838-0	2020	Quercetin-Resveratrol Combination for Prostate Cancer Management in TRAMP Mice.	Quercetin	0-9	tumor necrosis factor receptor superfamily, member 25	Mus musculus	68-73
32748838-3	2020	Here, we determined the effects of grape antioxidants quercetin and/or resveratrol (60 and 600 mg/kg, respectively, in diet) against PCa in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP)-model in prevention and intervention settings.	Quercetin	54-63	tumor necrosis factor receptor superfamily, member 25	Mus musculus	185-190
32748838-6	2020	Utilizing PCa PCR array analysis with prevention tumor tissues, we identified that quercetin-resveratrol modulates genes involved in promoter methylation, cell cycle, apoptosis, fatty acid metabolism, transcription factors, androgen response, PI3K/AKT and PTEN signaling.	Quercetin	83-92	thymoma viral proto-oncogene 1	Mus musculus	248-251
32748838-6	2020	Utilizing PCa PCR array analysis with prevention tumor tissues, we identified that quercetin-resveratrol modulates genes involved in promoter methylation, cell cycle, apoptosis, fatty acid metabolism, transcription factors, androgen response, PI3K/AKT and PTEN signaling.	Quercetin	83-92	phosphatase and tensin homolog	Mus musculus	256-260
32761308-5	2020	Quercetin significantly reduced J-point elevation, heart rate, reactive oxygen species, serum levels of myocardial enzymes, superoxide dismutase, catalase, glutathione, glutathione peroxidase, glutathione S-transferase and improved heart pathologic morphology.	Quercetin	0-9	catalase	Rattus norvegicus	146-154
32761308-5	2020	Quercetin significantly reduced J-point elevation, heart rate, reactive oxygen species, serum levels of myocardial enzymes, superoxide dismutase, catalase, glutathione, glutathione peroxidase, glutathione S-transferase and improved heart pathologic morphology.	Quercetin	0-9	hematopoietic prostaglandin D synthase	Rattus norvegicus	193-218
32761338-9	2020	RESULTS: Co-treatment with Q, C, H and their combination promoted Schwann cell differentiation, increased CNTF secretion, up-regulated the protein and mRNA expressions of myelin, and increased the number and length of the myelin segments (P<0.01 or P<0.05).	Quercetin	27-28	ciliary neurotrophic factor	Homo sapiens	106-110
32643448-12	2020	The results of molecular docking showed that baicalein and quercetin were the top two compounds of HSBDF, which had high affinity with ACE2.	Quercetin	59-68	angiotensin converting enzyme 2	Homo sapiens	135-139
32643448-13	2020	CONCLUSION: Baicalein and quercetin in HSBDF may regulate multiple signaling pathways through ACE2, which might play a therapeutic role on COVID-19.	Quercetin	26-35	angiotensin converting enzyme 2	Homo sapiens	94-98
32742328-6	2020	It was noted that quercetin attenuated the KA-induced seizure score and proinflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and activation of nuclear factor kappaB (NF-kappaB) in mice.	Quercetin	18-27	tumor necrosis factor	Mus musculus	119-146
32527528-7	2020	In addition, cleavages of Cas 3 and PARP were obtained in cells treated with Q.	Quercetin	77-78	poly (ADP-ribose) polymerase family, member 1	Mus musculus	36-40
32742328-6	2020	It was noted that quercetin attenuated the KA-induced seizure score and proinflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and activation of nuclear factor kappaB (NF-kappaB) in mice.	Quercetin	18-27	tumor necrosis factor	Mus musculus	148-157
32742328-6	2020	It was noted that quercetin attenuated the KA-induced seizure score and proinflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and activation of nuclear factor kappaB (NF-kappaB) in mice.	Quercetin	18-27	interleukin 1 beta	Mus musculus	163-180
32742328-6	2020	It was noted that quercetin attenuated the KA-induced seizure score and proinflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and activation of nuclear factor kappaB (NF-kappaB) in mice.	Quercetin	18-27	interleukin 1 alpha	Mus musculus	182-190
32742328-6	2020	It was noted that quercetin attenuated the KA-induced seizure score and proinflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and activation of nuclear factor kappaB (NF-kappaB) in mice.	Quercetin	18-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	234-243
32742328-7	2020	Quercetin attenuated KA-induced proinflammatory cytokine (TNF-alpha and IL-1beta) release from microglia cells, as well as activation of NF-kappaB and ionized calcium binding adapter molecule 1 in microglia cells.	Quercetin	0-9	tumor necrosis factor	Mus musculus	58-67
32742328-7	2020	Quercetin attenuated KA-induced proinflammatory cytokine (TNF-alpha and IL-1beta) release from microglia cells, as well as activation of NF-kappaB and ionized calcium binding adapter molecule 1 in microglia cells.	Quercetin	0-9	interleukin 1 alpha	Mus musculus	72-80
32742328-7	2020	Quercetin attenuated KA-induced proinflammatory cytokine (TNF-alpha and IL-1beta) release from microglia cells, as well as activation of NF-kappaB and ionized calcium binding adapter molecule 1 in microglia cells.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	137-146
32742328-7	2020	Quercetin attenuated KA-induced proinflammatory cytokine (TNF-alpha and IL-1beta) release from microglia cells, as well as activation of NF-kappaB and ionized calcium binding adapter molecule 1 in microglia cells.	Quercetin	0-9	allograft inflammatory factor 1	Mus musculus	151-193
32742328-8	2020	Therefore, quercetin inhibited KA-induced epilepsy by microglia cell inactivation and the production of NF-kappaB, TNF-alpha and IL-1beta.	Quercetin	11-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	104-113
32742328-8	2020	Therefore, quercetin inhibited KA-induced epilepsy by microglia cell inactivation and the production of NF-kappaB, TNF-alpha and IL-1beta.	Quercetin	11-20	tumor necrosis factor	Mus musculus	115-124
32742328-8	2020	Therefore, quercetin inhibited KA-induced epilepsy by microglia cell inactivation and the production of NF-kappaB, TNF-alpha and IL-1beta.	Quercetin	11-20	interleukin 1 alpha	Mus musculus	129-137
32492628-0	2020	Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway.	Quercetin	0-9	NLR family, pyrin domain containing 3	Rattus norvegicus	21-26
32397768-6	2020	Cell proliferation, expression of IL-2, calcium mobilization, apoptosis, cell cycle, and phosphorylation of extracellular signal-regulated kinase (ERK) were investigated.Results: Quercetin induced HO-1, and this induction of HO-1 was implicated in the suppression of IL-2 production.	Quercetin	179-188	heme oxygenase 1	Mus musculus	197-201
32397768-6	2020	Cell proliferation, expression of IL-2, calcium mobilization, apoptosis, cell cycle, and phosphorylation of extracellular signal-regulated kinase (ERK) were investigated.Results: Quercetin induced HO-1, and this induction of HO-1 was implicated in the suppression of IL-2 production.	Quercetin	179-188	interleukin 2	Mus musculus	267-271
32397768-7	2020	Furthermore, the induction of HO-1 by quercetin suppressed the influx of calcium ions, a known trigger of IL-2 production.	Quercetin	38-47	heme oxygenase 1	Mus musculus	30-34
32397768-7	2020	Furthermore, the induction of HO-1 by quercetin suppressed the influx of calcium ions, a known trigger of IL-2 production.	Quercetin	38-47	interleukin 2	Mus musculus	106-110
32397768-8	2020	Additionally, quercetin suppressed T cell proliferation through promotion of cell cycle arrest via HO-1 induction, but quercetin did not induce apoptosis.	Quercetin	14-23	heme oxygenase 1	Mus musculus	99-103
32397768-9	2020	To investigate the role of the signal transduction pathway in quercetin"s effect on cell proliferation, we evaluated the phosphorylation of ERK in T cells.	Quercetin	62-71	mitogen-activated protein kinase 1	Mus musculus	140-143
32397768-10	2020	Quercetin suppressed the A23187-mediated stimulation of ERK, an effect that was mediated through HO-1.	Quercetin	0-9	mitogen-activated protein kinase 1	Mus musculus	56-59
32397768-10	2020	Quercetin suppressed the A23187-mediated stimulation of ERK, an effect that was mediated through HO-1.	Quercetin	0-9	heme oxygenase 1	Mus musculus	97-101
32397768-11	2020	These results suggested that HO-1 is involved in the suppressive effects of quercetin on T cell activation and proliferation.Conclusion: Our findings indicate that the quercetin may be a promising candidate for inducing HO-1 in T cells, thereby facilitating immunosuppressive effects.	Quercetin	76-85	heme oxygenase 1	Mus musculus	29-33
32397768-11	2020	These results suggested that HO-1 is involved in the suppressive effects of quercetin on T cell activation and proliferation.Conclusion: Our findings indicate that the quercetin may be a promising candidate for inducing HO-1 in T cells, thereby facilitating immunosuppressive effects.	Quercetin	76-85	heme oxygenase 1	Mus musculus	220-224
32397768-11	2020	These results suggested that HO-1 is involved in the suppressive effects of quercetin on T cell activation and proliferation.Conclusion: Our findings indicate that the quercetin may be a promising candidate for inducing HO-1 in T cells, thereby facilitating immunosuppressive effects.	Quercetin	168-177	heme oxygenase 1	Mus musculus	29-33
32397768-11	2020	These results suggested that HO-1 is involved in the suppressive effects of quercetin on T cell activation and proliferation.Conclusion: Our findings indicate that the quercetin may be a promising candidate for inducing HO-1 in T cells, thereby facilitating immunosuppressive effects.	Quercetin	168-177	heme oxygenase 1	Mus musculus	220-224
32397768-0	2020	Involvement of heme oxygenase-1 in suppression of T cell activation by quercetin.	Quercetin	71-80	heme oxygenase 1	Mus musculus	15-31
32397768-3	2020	Quercetin, a flavonoid found in fruits and vegetables, has been demonstrated to exhibit cytoprotective effects through the induction of heme oxygenase (HO) -1, an enzyme involved in heme catabolism.	Quercetin	0-9	heme oxygenase 1	Mus musculus	136-158
32397768-4	2020	We hypothesized that quercetin induces HO-1 in T cells and suppresses T cell function via HO-1.	Quercetin	21-30	heme oxygenase 1	Mus musculus	39-43
32397768-4	2020	We hypothesized that quercetin induces HO-1 in T cells and suppresses T cell function via HO-1.	Quercetin	21-30	heme oxygenase 1	Mus musculus	90-94
32397768-5	2020	In the present study, we showed that quercetin suppressed the A23187-mediated expression of interleukin (IL) -2 in T cells.Methods: Mouse splenocytes, enriched T cells, and EL4 cells, a mouse T cell line, were treated with quercetin, and then stimulated with A23187, a calcium ionophore, concanavalin A, or anti-CD3epsilon and anti-CD28 antibodies.	Quercetin	37-46	interleukin 2	Mus musculus	92-111
32397768-5	2020	In the present study, we showed that quercetin suppressed the A23187-mediated expression of interleukin (IL) -2 in T cells.Methods: Mouse splenocytes, enriched T cells, and EL4 cells, a mouse T cell line, were treated with quercetin, and then stimulated with A23187, a calcium ionophore, concanavalin A, or anti-CD3epsilon and anti-CD28 antibodies.	Quercetin	37-46	CD3 antigen, epsilon polypeptide	Mus musculus	312-322
32397768-5	2020	In the present study, we showed that quercetin suppressed the A23187-mediated expression of interleukin (IL) -2 in T cells.Methods: Mouse splenocytes, enriched T cells, and EL4 cells, a mouse T cell line, were treated with quercetin, and then stimulated with A23187, a calcium ionophore, concanavalin A, or anti-CD3epsilon and anti-CD28 antibodies.	Quercetin	37-46	CD28 antigen	Mus musculus	332-336
32492628-0	2020	Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	116-121
32492628-8	2020	Meanwhile, Que significantly inhibited the level of tumor suppressor P53, Bax, cleaved-cas3 expressionl and increased Bcl-2 expression to reduce apoptosis in vivo and in vitro.	Quercetin	11-14	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	69-72
32492628-8	2020	Meanwhile, Que significantly inhibited the level of tumor suppressor P53, Bax, cleaved-cas3 expressionl and increased Bcl-2 expression to reduce apoptosis in vivo and in vitro.	Quercetin	11-14	BCL2 associated X, apoptosis regulator	Rattus norvegicus	74-77
32492628-8	2020	Meanwhile, Que significantly inhibited the level of tumor suppressor P53, Bax, cleaved-cas3 expressionl and increased Bcl-2 expression to reduce apoptosis in vivo and in vitro.	Quercetin	11-14	BCL2, apoptosis regulator	Rattus norvegicus	118-123
32492628-10	2020	In short, our findings showed that Que exhibited protective effects against INH-induced liver damage via inhibiting the activation of NLRP3 inflammasome and apoptosis in a SIRT-dependent manner.	Quercetin	35-38	NLR family, pyrin domain containing 3	Rattus norvegicus	134-139
33214336-10	2020	Quercetin administration diminished the exudate and degree of inflammation in lamina propria of nasal and sinusal areas, parallel with the decreased secretion of TNF-alpha (40.2% reduction after the low dose of LPS, and 35.4% reduction after the high dose of LPS) and IL-6 (21.4% reduction after the low dose of LPS and 35.8% reduction after the high dose of LPS).	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	162-171
33214336-10	2020	Quercetin administration diminished the exudate and degree of inflammation in lamina propria of nasal and sinusal areas, parallel with the decreased secretion of TNF-alpha (40.2% reduction after the low dose of LPS, and 35.4% reduction after the high dose of LPS) and IL-6 (21.4% reduction after the low dose of LPS and 35.8% reduction after the high dose of LPS).	Quercetin	0-9	interleukin 6	Rattus norvegicus	268-272
33214336-11	2020	In lungs, quercetin reduced TNF-alpha (43.3%) and IL-6 levels (24.5%), and in the brain, the protective effect was noticed only on TNF-alpha (46.5%).	Quercetin	10-19	tumor necrosis factor	Rattus norvegicus	28-37
33214336-11	2020	In lungs, quercetin reduced TNF-alpha (43.3%) and IL-6 levels (24.5%), and in the brain, the protective effect was noticed only on TNF-alpha (46.5%).	Quercetin	10-19	interleukin 6	Rattus norvegicus	50-54
32798404-9	2020	CONCLUSION: Quercetin mediates anti-myeloma effects through inducing apoptosis, cell cycle arrest and down-regulating ERK and AKT pathways in human myeloma cells.	Quercetin	12-21	mitogen-activated protein kinase 1	Homo sapiens	118-121
32588871-0	2020	Quercetin protects ARPE-19 cells against photic stress mediated by the products of rhodopsin photobleaching.	Quercetin	0-9	rhodopsin	Homo sapiens	83-92
32588871-9	2020	Cytotoxicity measurements and MMP analyses confirmed that supplementation with quercetin protected ARPE-19 cells against photic stress mediated by rhodopsin-rich POS.	Quercetin	79-88	rhodopsin	Homo sapiens	147-156
32798404-9	2020	CONCLUSION: Quercetin mediates anti-myeloma effects through inducing apoptosis, cell cycle arrest and down-regulating ERK and AKT pathways in human myeloma cells.	Quercetin	12-21	AKT serine/threonine kinase 1	Homo sapiens	126-129
32751563-7	2020	Results: Treatment of cells with quercetin at more than 5.0 muM inhibited the production of IL-5 and IL-13 from CD4+ T cells induced by IL-4 stimulation through the suppression of transcription factor activation and cytokine mRNA expression.	Quercetin	33-42	interleukin 5	Homo sapiens	92-96
32751996-0	2020	Inhibitory Effects of Quercetin and Its Main Methyl, Sulfate, and Glucuronic Acid Conjugates on Cytochrome P450 Enzymes, and on OATP, BCRP and MRP2 Transporters.	Quercetin	22-31	BCR pseudogene 1	Homo sapiens	134-138
32751996-0	2020	Inhibitory Effects of Quercetin and Its Main Methyl, Sulfate, and Glucuronic Acid Conjugates on Cytochrome P450 Enzymes, and on OATP, BCRP and MRP2 Transporters.	Quercetin	22-31	ATP binding cassette subfamily C member 2	Homo sapiens	143-147
32751996-6	2020	Quercetin and its metabolites (quercetin-3"-sulfate, quercetin-3-glucuronide, isorhamnetin, and isorhamnetin-3-glucuronide) showed weak inhibitory effects on CYP2C19 and 3A4, while they did not affect CYP2D6 activity.	Quercetin	0-9	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	158-165
32751996-6	2020	Quercetin and its metabolites (quercetin-3"-sulfate, quercetin-3-glucuronide, isorhamnetin, and isorhamnetin-3-glucuronide) showed weak inhibitory effects on CYP2C19 and 3A4, while they did not affect CYP2D6 activity.	Quercetin	0-9	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	201-207
32751563-7	2020	Results: Treatment of cells with quercetin at more than 5.0 muM inhibited the production of IL-5 and IL-13 from CD4+ T cells induced by IL-4 stimulation through the suppression of transcription factor activation and cytokine mRNA expression.	Quercetin	33-42	interleukin 13	Homo sapiens	101-106
32751563-7	2020	Results: Treatment of cells with quercetin at more than 5.0 muM inhibited the production of IL-5 and IL-13 from CD4+ T cells induced by IL-4 stimulation through the suppression of transcription factor activation and cytokine mRNA expression.	Quercetin	33-42	CD4 molecule	Homo sapiens	112-115
32751563-7	2020	Results: Treatment of cells with quercetin at more than 5.0 muM inhibited the production of IL-5 and IL-13 from CD4+ T cells induced by IL-4 stimulation through the suppression of transcription factor activation and cytokine mRNA expression.	Quercetin	33-42	interleukin 4	Homo sapiens	136-140
32751563-8	2020	On the other hand, quercetin at more than 5.0 muM abrogated the inhibitory action of IL-4 on INF-gamma production from CD4+ T cells in vitro.	Quercetin	19-28	interleukin 4	Homo sapiens	85-89
32751563-8	2020	On the other hand, quercetin at more than 5.0 muM abrogated the inhibitory action of IL-4 on INF-gamma production from CD4+ T cells in vitro.	Quercetin	19-28	CD4 molecule	Homo sapiens	119-122
32766279-10	2020	Further, evaluation of the function of Hsp70 using siRNA and quercetin, an inhibitor of Hsp70, showed that Hsp70 was necessary for the infection of echovirus type 9.	Quercetin	61-70	heat shock protein family A (Hsp70) member 4	Homo sapiens	88-93
32751373-4	2020	In this work, we have used mass-spectrometry-based lipidomics to characterize the changes in the phospholipidome of proinflammatory human-macrophage-like cells (THP-1-derived and LPS+IFN-gamma-stimulated) incubated with non-cytotoxic concentrations of three flavonoids: quercetin, naringin and naringenin.	Quercetin	270-279	GLI family zinc finger 2	Homo sapiens	161-166
32698689-7	2021	Further, our molecular dynamics (MD) simulation and energy landscape studies with fisetin, quercetin, and kamferol revealed that these molecules bind with the hACE2-S complex with low binding free energy.	Quercetin	91-100	angiotensin converting enzyme 2	Homo sapiens	159-164
32766279-10	2020	Further, evaluation of the function of Hsp70 using siRNA and quercetin, an inhibitor of Hsp70, showed that Hsp70 was necessary for the infection of echovirus type 9.	Quercetin	61-70	heat shock protein family A (Hsp70) member 4	Homo sapiens	88-93
32724490-4	2020	Molecular docking and fluorescence binding studies showed that EA and quercetin bind to the CaMKIV with a considerable affinity in comparison to other compounds.	Quercetin	70-79	calcium/calmodulin dependent protein kinase IV	Homo sapiens	92-98
32709024-7	2020	Quercetin can protect against dexamethasone-induced muscle atrophy by regulating the Bax/Bcl-2 ratio at the protein level and abnormal DeltaPsim, which leads to the suppression of apoptosis.	Quercetin	0-9	BCL2-associated X protein	Mus musculus	85-88
32709024-7	2020	Quercetin can protect against dexamethasone-induced muscle atrophy by regulating the Bax/Bcl-2 ratio at the protein level and abnormal DeltaPsim, which leads to the suppression of apoptosis.	Quercetin	0-9	B cell leukemia/lymphoma 2	Mus musculus	89-94
32724490-5	2020	Enzyme inhibition assay revealed that both EA and quercetin inhibit CaMKIV activity with their IC50 values in the micromolar range.	Quercetin	50-59	calcium/calmodulin dependent protein kinase IV	Homo sapiens	68-74
32724490-7	2020	Both EA and quercetin bind to the catalytically important residues of active site pocket of CaMKIV forming enough stabilizing interactions presumably inhibiting enzyme activity.	Quercetin	12-21	calcium/calmodulin dependent protein kinase IV	Homo sapiens	92-98
32220623-0	2020	Quercetin attenuated oxidative DNA damage through NRF2 signaling pathway in rats with DMH induced colon carcinogenesis.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	50-54
32220623-8	2020	In addition, quercetin also modulated NRF2/Keap1 signaling and its targets, detoxifying enzymes in DMH + Quercetin groups.	Quercetin	13-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-42
32220623-8	2020	In addition, quercetin also modulated NRF2/Keap1 signaling and its targets, detoxifying enzymes in DMH + Quercetin groups.	Quercetin	13-22	Kelch-like ECH-associated protein 1	Rattus norvegicus	43-48
32220623-8	2020	In addition, quercetin also modulated NRF2/Keap1 signaling and its targets, detoxifying enzymes in DMH + Quercetin groups.	Quercetin	105-114	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-42
32220623-8	2020	In addition, quercetin also modulated NRF2/Keap1 signaling and its targets, detoxifying enzymes in DMH + Quercetin groups.	Quercetin	105-114	Kelch-like ECH-associated protein 1	Rattus norvegicus	43-48
32220623-9	2020	Our finding demonstrated that quercetin supplementation effectively reversed DMH-mediated oxidative stress and DNA damage through targeting NRF2/Keap1 signaling pathway.	Quercetin	30-39	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144
32220623-9	2020	Our finding demonstrated that quercetin supplementation effectively reversed DMH-mediated oxidative stress and DNA damage through targeting NRF2/Keap1 signaling pathway.	Quercetin	30-39	Kelch-like ECH-associated protein 1	Rattus norvegicus	145-150
32549610-4	2020	and red wines added with increasing amounts of Q showed that, above 3 mgL-1 of Q, a deposit can be detected and, the time necessary for its formation depends on the medium.	Quercetin	47-48	LLGL scribble cell polarity complex component 1	Homo sapiens	70-75
32764874-11	2020	Molecular docking suggested that quercetin, baicalein, and wogonin combined well with AKT1 and JUN.	Quercetin	33-42	AKT serine/threonine kinase 1	Homo sapiens	86-90
32764874-12	2020	The in vitro experiment showed that quercetin, the most important ingredient of ZJW, could induce apoptosis of HCT116 cells through PI3K-Akt signaling pathway.	Quercetin	36-45	AKT serine/threonine kinase 1	Homo sapiens	137-140
32733640-0	2020	PI3K/Akt and ERK1/2 Signalling Are Involved in Quercetin-Mediated Neuroprotection against Copper-Induced Injury.	Quercetin	47-56	AKT serine/threonine kinase 1	Homo sapiens	5-8
32733640-0	2020	PI3K/Akt and ERK1/2 Signalling Are Involved in Quercetin-Mediated Neuroprotection against Copper-Induced Injury.	Quercetin	47-56	mitogen-activated protein kinase 3	Homo sapiens	13-19
32733640-4	2020	In moderately injured P19 neuronal cells, concomitant treatment with 150 muM quercetin improved viability by preventing ROS formation, caspase-3 activation, and chromatin condensation.	Quercetin	77-86	cyclin dependent kinase inhibitor 2D	Homo sapiens	22-25
32733640-4	2020	In moderately injured P19 neuronal cells, concomitant treatment with 150 muM quercetin improved viability by preventing ROS formation, caspase-3 activation, and chromatin condensation.	Quercetin	77-86	caspase 3	Homo sapiens	135-144
32733640-5	2020	Western blot analysis revealed that quercetin reduced copper-induced increase in p53 upregulated modulator of apoptosis (PUMA) expression and promoted upregulation of nucleoside diphosphate kinase NME1.	Quercetin	36-45	tumor protein p53	Homo sapiens	81-84
32733640-5	2020	Western blot analysis revealed that quercetin reduced copper-induced increase in p53 upregulated modulator of apoptosis (PUMA) expression and promoted upregulation of nucleoside diphosphate kinase NME1.	Quercetin	36-45	BCL2 binding component 3	Homo sapiens	121-125
32733640-5	2020	Western blot analysis revealed that quercetin reduced copper-induced increase in p53 upregulated modulator of apoptosis (PUMA) expression and promoted upregulation of nucleoside diphosphate kinase NME1.	Quercetin	36-45	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	197-201
32733640-7	2020	UO126 and wortmannin, inhibitors of ERK1/2 and PI3K/Akt signalling pathways, respectively, prevented neuroprotective effects of quercetin.	Quercetin	128-137	mitogen-activated protein kinase 3	Homo sapiens	36-42
32733640-7	2020	UO126 and wortmannin, inhibitors of ERK1/2 and PI3K/Akt signalling pathways, respectively, prevented neuroprotective effects of quercetin.	Quercetin	128-137	AKT serine/threonine kinase 1	Homo sapiens	52-55
32078205-0	2020	Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-66
32078205-9	2020	The liver oxidative stress markers in LT4-induced hyperthyroidism Nrf2 knockout rats were determined to evaluate the role of Nrf2 on quercetin induced protective effects.	Quercetin	133-142	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-129
32078205-12	2020	Furthermore, the loss function of Nrf2 diminished these effects resulting from the quercetin application, indicating the inhibitory effects caused by the quercetin may be involved in Nrf2 signaling pathway.	Quercetin	83-92	NFE2 like bZIP transcription factor 2	Rattus norvegicus	34-38
32078205-12	2020	Furthermore, the loss function of Nrf2 diminished these effects resulting from the quercetin application, indicating the inhibitory effects caused by the quercetin may be involved in Nrf2 signaling pathway.	Quercetin	83-92	NFE2 like bZIP transcription factor 2	Rattus norvegicus	183-187
32078205-12	2020	Furthermore, the loss function of Nrf2 diminished these effects resulting from the quercetin application, indicating the inhibitory effects caused by the quercetin may be involved in Nrf2 signaling pathway.	Quercetin	154-163	NFE2 like bZIP transcription factor 2	Rattus norvegicus	34-38
32078205-12	2020	Furthermore, the loss function of Nrf2 diminished these effects resulting from the quercetin application, indicating the inhibitory effects caused by the quercetin may be involved in Nrf2 signaling pathway.	Quercetin	154-163	NFE2 like bZIP transcription factor 2	Rattus norvegicus	183-187
32078205-13	2020	These results indicate that quercetin could be used to protect against experimental hyperthyroidism-induced liver damage via Nrf2 signaling pathway.	Quercetin	28-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-129
32115260-6	2020	Furthermore, treatment of LPS-DCs with quercetin resulted in a reduced production of the pro-inflammatory cytokine IL-12p70 and in an increased expression of the immunoregulatory molecules disabled adaptor protein (Dab) 2, immunoglobulin-like transcript (ILT)-3, ILT4, ILT5 as well as ectonucleotidases CD39 and CD73, thereby inducing a tolerogenic phenotype in quercetin-treated maturing DCs.	Quercetin	39-48	DAB adaptor protein 2	Homo sapiens	215-221
32115260-6	2020	Furthermore, treatment of LPS-DCs with quercetin resulted in a reduced production of the pro-inflammatory cytokine IL-12p70 and in an increased expression of the immunoregulatory molecules disabled adaptor protein (Dab) 2, immunoglobulin-like transcript (ILT)-3, ILT4, ILT5 as well as ectonucleotidases CD39 and CD73, thereby inducing a tolerogenic phenotype in quercetin-treated maturing DCs.	Quercetin	39-48	leukocyte immunoglobulin like receptor B4	Homo sapiens	223-261
32115260-6	2020	Furthermore, treatment of LPS-DCs with quercetin resulted in a reduced production of the pro-inflammatory cytokine IL-12p70 and in an increased expression of the immunoregulatory molecules disabled adaptor protein (Dab) 2, immunoglobulin-like transcript (ILT)-3, ILT4, ILT5 as well as ectonucleotidases CD39 and CD73, thereby inducing a tolerogenic phenotype in quercetin-treated maturing DCs.	Quercetin	39-48	leukocyte immunoglobulin like receptor B2	Homo sapiens	263-267
32115260-6	2020	Furthermore, treatment of LPS-DCs with quercetin resulted in a reduced production of the pro-inflammatory cytokine IL-12p70 and in an increased expression of the immunoregulatory molecules disabled adaptor protein (Dab) 2, immunoglobulin-like transcript (ILT)-3, ILT4, ILT5 as well as ectonucleotidases CD39 and CD73, thereby inducing a tolerogenic phenotype in quercetin-treated maturing DCs.	Quercetin	39-48	leukocyte immunoglobulin like receptor A6	Homo sapiens	269-273
32115260-6	2020	Furthermore, treatment of LPS-DCs with quercetin resulted in a reduced production of the pro-inflammatory cytokine IL-12p70 and in an increased expression of the immunoregulatory molecules disabled adaptor protein (Dab) 2, immunoglobulin-like transcript (ILT)-3, ILT4, ILT5 as well as ectonucleotidases CD39 and CD73, thereby inducing a tolerogenic phenotype in quercetin-treated maturing DCs.	Quercetin	39-48	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	303-307
32115260-6	2020	Furthermore, treatment of LPS-DCs with quercetin resulted in a reduced production of the pro-inflammatory cytokine IL-12p70 and in an increased expression of the immunoregulatory molecules disabled adaptor protein (Dab) 2, immunoglobulin-like transcript (ILT)-3, ILT4, ILT5 as well as ectonucleotidases CD39 and CD73, thereby inducing a tolerogenic phenotype in quercetin-treated maturing DCs.	Quercetin	39-48	5'-nucleotidase ecto	Homo sapiens	312-316
32660602-0	2020	Perillyle alcohol and Quercetin ameliorate monocrotaline-induced pulmonary artery hypertension in rats through PARP1-mediated miR-204 down-regulation and its downstream pathway.	Quercetin	22-31	poly (ADP-ribose) polymerase 1	Rattus norvegicus	111-116
32660602-0	2020	Perillyle alcohol and Quercetin ameliorate monocrotaline-induced pulmonary artery hypertension in rats through PARP1-mediated miR-204 down-regulation and its downstream pathway.	Quercetin	22-31	microRNA 204	Rattus norvegicus	126-133
32559841-6	2020	RESULTS: Quercetin not only reversed the decreased mechanical withdraw thresholds and intraepidermal nerve fiber densities in DPN rats, but also improved neurological morphology of sciatic nerves, accompanied with up-regulated percentage of paranodes at paranodal junctions, and down-regulated amyloid precursor protein and ionized calcium-binding adaptor molecule 1 in DPN rats.	Quercetin	9-18	amyloid beta precursor protein	Rattus norvegicus	294-319
33102196-9	2020	Docking tests confirmed that quercetin, chlorogenic acid, epicatechin, and catechins depicted HMGR inhibition.	Quercetin	29-38	3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like	Malus domestica	94-98
33102196-10	2020	Quercetin could bind to HMGR at a similar location to amino acid residues as simvastatin.	Quercetin	0-9	3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like	Malus domestica	24-28
32549610-4	2020	and red wines added with increasing amounts of Q showed that, above 3 mgL-1 of Q, a deposit can be detected and, the time necessary for its formation depends on the medium.	Quercetin	79-80	LLGL scribble cell polarity complex component 1	Homo sapiens	70-75
32097726-8	2020	IC50 values were determined to be 0.018 and 0.029 mM for potato PPO with curcumin and quercetin inhibitors with catechol as a substrate, respectively.	Quercetin	86-95	catechol oxidase B, chloroplastic	Solanum tuberosum	64-67
32832891-8	2020	Results: At 4 and at 24 hours, curcumin and quercetin have shown protective systemic effects, decreasing significantly the oxidative stress (malondialdehyde level) and stimulating significantly the antioxidant protection (ceruloplasmin and glutathione levels) compared to the group that received only carrageenan.	Quercetin	44-53	ceruloplasmin	Rattus norvegicus	222-235
32638319-8	2020	Quercetin effectively suppressed the expression of Hsp27, Hsp70 and Hsp90.	Quercetin	0-9	heat shock protein family B (small) member 1	Homo sapiens	51-56
32638319-8	2020	Quercetin effectively suppressed the expression of Hsp27, Hsp70 and Hsp90.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	58-63
32638319-8	2020	Quercetin effectively suppressed the expression of Hsp27, Hsp70 and Hsp90.	Quercetin	0-9	heat shock protein 90 alpha family class A member 1	Homo sapiens	68-73
32638319-10	2020	Although an increase in NF-kappaB levels is observed in the cells exposed to quercetin, the net result is the anticancer effect in case of Hsp depletion and apoptosis induction.	Quercetin	77-86	nuclear factor kappa B subunit 1	Homo sapiens	24-33
31791158-8	2020	Quercetin predominantly repressed cell viability, migration, VEGF expression and facilitated apoptosis in HMEC-1 cells.	Quercetin	0-9	vascular endothelial growth factor A	Homo sapiens	61-65
31791158-9	2020	Additionally, suppression of miR-216a was discovered in HMEC-1 cells after quercetin stimulation, meanwhile miR-216a overexpression annulled the functions of quercetin in HMEC-1 cells.	Quercetin	75-84	microRNA 216a	Homo sapiens	29-37
31791158-9	2020	Additionally, suppression of miR-216a was discovered in HMEC-1 cells after quercetin stimulation, meanwhile miR-216a overexpression annulled the functions of quercetin in HMEC-1 cells.	Quercetin	158-167	microRNA 216a	Homo sapiens	108-116
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	9-18	AKT serine/threonine kinase 1	Homo sapiens	36-39
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	9-18	microRNA 216a	Homo sapiens	80-88
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	9-18	Janus kinase 2	Homo sapiens	240-244
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	9-18	signal transducer and activator of transcription 3	Homo sapiens	245-250
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	9-18	AKT serine/threonine kinase 1	Homo sapiens	260-263
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	9-18	microRNA 216a	Homo sapiens	291-299
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	149-158	AKT serine/threonine kinase 1	Homo sapiens	36-39
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	149-158	microRNA 216a	Homo sapiens	80-88
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	149-158	Janus kinase 2	Homo sapiens	240-244
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	149-158	signal transducer and activator of transcription 3	Homo sapiens	245-250
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	149-158	AKT serine/threonine kinase 1	Homo sapiens	260-263
31791158-10	2020	Besides, quercetin deactivated PI3K/AKT and JAK/STAT pathways through adjusting miR-216a.Conclusion: The above-mentioned consequences exhibited that quercetin suppressed HMEC-1 cell viability, migration and tube-formation through hindering JAK2/STAT3 and PI3K/AKT pathway via declination of miR-216a.	Quercetin	149-158	microRNA 216a	Homo sapiens	291-299
32097726-0	2020	A new insight into purification of polyphenol oxidase and inhibition effect of curcumin and quercetin on potato polyphenol oxidase.	Quercetin	92-101	catechol oxidase B, chloroplastic	Solanum tuberosum	112-130
32597315-7	2021	Phenformin, quercetin, and ritonavir all demonstrated prospective binding affinities for COVID-19 PLpro over 50 ns MD simulations, with binding energy values of -56.6, -40.9, and -37.6 kcal/mol, respectively.	Quercetin	12-21	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	98-103
32366711-6	2020	The mechanism of action of the most active compound, Quercetin, showing an IC50 value of 7.4 muM, was characterized to significantly restore the IFN-I signaling cascade, blocked by VP24, by directly interfering with the VP24 binding to karyopherin-alpha and thus restoring P-STAT1 nuclear transport and IFN genes transcription.	Quercetin	53-62	signal transducer and activator of transcription 1	Homo sapiens	275-280
32605155-2	2020	The digest of ABS contained quercetin and kaempferol derivates, while kaempferol and apigenin derivates were dominant in MBS.	Quercetin	28-37	DEAD-box helicase 41	Homo sapiens	14-17
32655759-6	2020	Furthermore, the three treatments enhanced the mRNA expression of GLUT-4 and the insulin receptor beta-subunit, but only quercetin produced a significant increase in the expression of adiponectin in adipose tissue of diabetic rats.	Quercetin	121-130	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	184-195
32555682-0	2020	Quercetin treatment reduces the severity of renal dysplasia in a beta-catenin dependent manner.	Quercetin	0-9	catenin beta 1	Homo sapiens	65-77
32660180-13	2020	Conclusion: CO/HO-1 metabolite mediates the protective effect of quercetin on alcoholic oxidative damage of hepatocytes, which may be related to the inhibition of CYP2E1 activity.	Quercetin	65-74	heme oxygenase 1	Rattus norvegicus	15-19
32660180-13	2020	Conclusion: CO/HO-1 metabolite mediates the protective effect of quercetin on alcoholic oxidative damage of hepatocytes, which may be related to the inhibition of CYP2E1 activity.	Quercetin	65-74	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	163-169
32660180-0	2020	[Study on the role and possible mechanism of hemeoxygenase-1/carbon monoxide system in protection of quercetin against ethanol-induced hepatocytes oxidative injury].	Quercetin	101-110	heme oxygenase 1	Rattus norvegicus	45-60
32660180-1	2020	Objective: To study the protective effect and potential mechanism of heme oxygenase (HO-1)/carbon monoxide (CO)-mediated quercetin on alcoholic oxidative damage of primary rat hepatocytes.	Quercetin	121-130	heme oxygenase 1	Rattus norvegicus	85-89
32660180-5	2020	The alone or combined effects of quercetin, CORM-2, hemoglobin and zinc protoporphyrin IX exposed to ethanol were detected by the activity of CYP2E1 in liver microsomes.	Quercetin	33-42	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	142-148
32660180-11	2020	Quercetin or CORM-2 had inhibited CYP2E1 activity, while hemoglobin or protoporphyrin IX had eliminated quercetin inhibitory effect and had increased the CYP2E1 activity.	Quercetin	0-9	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	34-40
32555682-3	2020	Quercetin, a naturally occurring flavonoid, reduces nuclear beta-catenin levels and reduces beta-catenin transcriptional activity.	Quercetin	0-9	catenin beta 1	Homo sapiens	60-72
32555682-3	2020	Quercetin, a naturally occurring flavonoid, reduces nuclear beta-catenin levels and reduces beta-catenin transcriptional activity.	Quercetin	0-9	catenin beta 1	Homo sapiens	92-104
32555682-4	2020	In this study, we utilized wild type and dysplastic mouse kidney organ explants to determine if quercetin reduces beta-catenin activity during kidney development and whether it improves the severity of renal dysplasia.	Quercetin	96-105	catenin (cadherin associated protein), beta 1	Mus musculus	114-126
32555682-6	2020	In wild type embryonic kidneys, quercetin reduced nuclear beta-catenin expression and decreased expression of beta-catenin target genes Pax2, Six2, and Gdnf, which are essential for kidney development.	Quercetin	32-41	catenin (cadherin associated protein), beta 1	Mus musculus	58-70
32555682-6	2020	In wild type embryonic kidneys, quercetin reduced nuclear beta-catenin expression and decreased expression of beta-catenin target genes Pax2, Six2, and Gdnf, which are essential for kidney development.	Quercetin	32-41	catenin (cadherin associated protein), beta 1	Mus musculus	110-122
32555682-6	2020	In wild type embryonic kidneys, quercetin reduced nuclear beta-catenin expression and decreased expression of beta-catenin target genes Pax2, Six2, and Gdnf, which are essential for kidney development.	Quercetin	32-41	paired box 2	Homo sapiens	136-140
32555682-6	2020	In wild type embryonic kidneys, quercetin reduced nuclear beta-catenin expression and decreased expression of beta-catenin target genes Pax2, Six2, and Gdnf, which are essential for kidney development.	Quercetin	32-41	SIX homeobox 2	Homo sapiens	142-146
32555682-6	2020	In wild type embryonic kidneys, quercetin reduced nuclear beta-catenin expression and decreased expression of beta-catenin target genes Pax2, Six2, and Gdnf, which are essential for kidney development.	Quercetin	32-41	glial cell derived neurotrophic factor	Homo sapiens	152-156
32555682-9	2020	Quercetin treatment also resulted in reduced nuclear beta-catenin and reduced Pax2 expression.	Quercetin	0-9	catenin beta 1	Homo sapiens	53-65
32555682-9	2020	Quercetin treatment also resulted in reduced nuclear beta-catenin and reduced Pax2 expression.	Quercetin	0-9	paired box 2	Homo sapiens	78-82
32555682-12	2020	Taken together, these data demonstrate that quercetin treatment reduces nuclear beta-catenin and this is associated with improved epithelial organization of developing nephrons, resulting in increased developing nephrons and a partial rescue of renal dysplasia.	Quercetin	44-53	catenin beta 1	Homo sapiens	80-92
32276170-5	2020	Before exposure to AgNPs, free quercetin-treated diet significantly upregulated Keap1, Nrf2, Cat, SOD, GPx, and GST genes in the liver tissue when compared with the control diet, whereas Qu-Chi.NPs downregulated their transcription to the lowest levels.	Quercetin	31-40	kelch-like ECH-associated protein 1a	Danio rerio	80-85
32536965-14	2020	Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2).	Quercetin	119-128	interleukin 6	Homo sapiens	210-213
32536965-14	2020	Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2).	Quercetin	119-128	interleukin 1 beta	Homo sapiens	215-219
32536965-14	2020	Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2).	Quercetin	119-128	C-C motif chemokine ligand 2	Homo sapiens	221-225
32276170-5	2020	Before exposure to AgNPs, free quercetin-treated diet significantly upregulated Keap1, Nrf2, Cat, SOD, GPx, and GST genes in the liver tissue when compared with the control diet, whereas Qu-Chi.NPs downregulated their transcription to the lowest levels.	Quercetin	31-40	nfe2 like bZIP transcription factor 2a	Danio rerio	87-91
32276170-5	2020	Before exposure to AgNPs, free quercetin-treated diet significantly upregulated Keap1, Nrf2, Cat, SOD, GPx, and GST genes in the liver tissue when compared with the control diet, whereas Qu-Chi.NPs downregulated their transcription to the lowest levels.	Quercetin	31-40	catalase	Danio rerio	93-96
32276170-9	2020	The quercetin treatments, especially Qu-Chi.NPs, significantly reduced the transcription of Nrf2, Cat, SOD, GPx, and GST genes, yet enhanced Keap1 expression.	Quercetin	4-13	nfe2 like bZIP transcription factor 2a	Danio rerio	92-96
32276170-9	2020	The quercetin treatments, especially Qu-Chi.NPs, significantly reduced the transcription of Nrf2, Cat, SOD, GPx, and GST genes, yet enhanced Keap1 expression.	Quercetin	4-13	catalase	Danio rerio	98-101
32276170-9	2020	The quercetin treatments, especially Qu-Chi.NPs, significantly reduced the transcription of Nrf2, Cat, SOD, GPx, and GST genes, yet enhanced Keap1 expression.	Quercetin	4-13	kelch-like ECH-associated protein 1a	Danio rerio	141-146
32344103-0	2020	MicroRNA-based regulatory mechanisms underlying the synergistic antioxidant action of quercetin and catechin in H2O2-stimulated HepG2 cells: Roles of BACH1 in Nrf2-dependent pathways.	Quercetin	86-95	NFE2 like bZIP transcription factor 2	Homo sapiens	159-163
32267561-2	2020	We previously demonstrated that quercetin transiently preserved respiratory function in dystrophin-deficient mice.	Quercetin	32-41	dystrophin, muscular dystrophy	Mus musculus	88-98
32344103-3	2020	It was confirmed that BACH1 serves as an essential and direct negative regulator of the Keap1-Nrf2 signaling pathway and the antioxidant synergism between quercetin and catechin.	Quercetin	155-164	BTB domain and CNC homolog 1	Homo sapiens	22-27
32344103-3	2020	It was confirmed that BACH1 serves as an essential and direct negative regulator of the Keap1-Nrf2 signaling pathway and the antioxidant synergism between quercetin and catechin.	Quercetin	155-164	kelch like ECH associated protein 1	Homo sapiens	88-93
32344103-3	2020	It was confirmed that BACH1 serves as an essential and direct negative regulator of the Keap1-Nrf2 signaling pathway and the antioxidant synergism between quercetin and catechin.	Quercetin	155-164	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
32344103-4	2020	BACH1 promoted reactive oxygen species (ROS) accumulation while inhibiting cell growth, which could be reversed by the synergistic action of let-7a-5p and miR-25-3p in the co-presence of quercetin and catechin.	Quercetin	187-196	BTB domain and CNC homolog 1	Homo sapiens	0-5
32253952-5	2020	Protein and mRNA expression of nuclear orphan receptors and cytochrome P450 enzymes were measured by Western Blotting and qPCR, respectively.Results: Que significantly reduced circulating ALT, AST, ALP, and ameliorated LPS-induced histological alterations.	Quercetin	150-153	glutamic pyruvic transaminase, soluble	Mus musculus	188-191
32216502-0	2020	Quercetin suppresses migration and invasion by targeting miR-146a/GATA6 axis in fibroblast-like synoviocytes of rheumatoid arthritis.	Quercetin	0-9	microRNA 146a	Homo sapiens	57-65
32216502-13	2020	In addition, specific anti-miR-146a inhibitor abolished quercetin-mediated suppression of migration and invasion of FLSs.Conclusion: Our study suggested that quercetin suppresses the migration and invasion of FLSs via regulating the miR-146a/GATA6 axis.	Quercetin	158-167	microRNA 146a	Homo sapiens	233-241
32216502-13	2020	In addition, specific anti-miR-146a inhibitor abolished quercetin-mediated suppression of migration and invasion of FLSs.Conclusion: Our study suggested that quercetin suppresses the migration and invasion of FLSs via regulating the miR-146a/GATA6 axis.	Quercetin	158-167	GATA binding protein 6	Homo sapiens	242-247
32216502-0	2020	Quercetin suppresses migration and invasion by targeting miR-146a/GATA6 axis in fibroblast-like synoviocytes of rheumatoid arthritis.	Quercetin	0-9	GATA binding protein 6	Homo sapiens	66-71
32216502-8	2020	The correlation between miR-146a and GATA6 was validated using luciferase reporter assay.Results: Transwell assay revealed that the migration and invasion of FLSs were significantly inhibited after quercetin treatment, which was also proved by decreased expression of F-actin.	Quercetin	198-207	microRNA 146a	Homo sapiens	24-32
32216502-8	2020	The correlation between miR-146a and GATA6 was validated using luciferase reporter assay.Results: Transwell assay revealed that the migration and invasion of FLSs were significantly inhibited after quercetin treatment, which was also proved by decreased expression of F-actin.	Quercetin	198-207	GATA binding protein 6	Homo sapiens	37-42
32216502-10	2020	Quercetin treatment elevated the RNA level of miR-146a, but suppressed the expression of GATA6 in FLSs.	Quercetin	0-9	microRNA 146a	Homo sapiens	46-54
32216502-10	2020	Quercetin treatment elevated the RNA level of miR-146a, but suppressed the expression of GATA6 in FLSs.	Quercetin	0-9	GATA binding protein 6	Homo sapiens	89-94
32216502-13	2020	In addition, specific anti-miR-146a inhibitor abolished quercetin-mediated suppression of migration and invasion of FLSs.Conclusion: Our study suggested that quercetin suppresses the migration and invasion of FLSs via regulating the miR-146a/GATA6 axis.	Quercetin	56-65	microRNA 146a	Homo sapiens	27-35
32216502-13	2020	In addition, specific anti-miR-146a inhibitor abolished quercetin-mediated suppression of migration and invasion of FLSs.Conclusion: Our study suggested that quercetin suppresses the migration and invasion of FLSs via regulating the miR-146a/GATA6 axis.	Quercetin	56-65	microRNA 146a	Homo sapiens	233-241
32253952-5	2020	Protein and mRNA expression of nuclear orphan receptors and cytochrome P450 enzymes were measured by Western Blotting and qPCR, respectively.Results: Que significantly reduced circulating ALT, AST, ALP, and ameliorated LPS-induced histological alterations.	Quercetin	150-153	transmembrane protease, serine 11d	Mus musculus	193-196
32216502-13	2020	In addition, specific anti-miR-146a inhibitor abolished quercetin-mediated suppression of migration and invasion of FLSs.Conclusion: Our study suggested that quercetin suppresses the migration and invasion of FLSs via regulating the miR-146a/GATA6 axis.	Quercetin	56-65	GATA binding protein 6	Homo sapiens	242-247
32216502-13	2020	In addition, specific anti-miR-146a inhibitor abolished quercetin-mediated suppression of migration and invasion of FLSs.Conclusion: Our study suggested that quercetin suppresses the migration and invasion of FLSs via regulating the miR-146a/GATA6 axis.	Quercetin	158-167	microRNA 146a	Homo sapiens	27-35
32253952-5	2020	Protein and mRNA expression of nuclear orphan receptors and cytochrome P450 enzymes were measured by Western Blotting and qPCR, respectively.Results: Que significantly reduced circulating ALT, AST, ALP, and ameliorated LPS-induced histological alterations.	Quercetin	150-153	alopecia, recessive	Mus musculus	198-201
32253952-7	2020	Furthermore, Que carried out the hepatoprotective effect via regulation of the expression of nuclear orphan receptors (CAR, PXR) and cytochrome P450 enzymes (CYP1A2, CYP2E1, CYP2D22, CYP3A11).Conclusions: Our findings suggested that Que pretreatment could ameliorate LPS-induced liver injury.	Quercetin	13-16	nuclear receptor subfamily 1, group I, member 3	Mus musculus	119-122
32253952-7	2020	Furthermore, Que carried out the hepatoprotective effect via regulation of the expression of nuclear orphan receptors (CAR, PXR) and cytochrome P450 enzymes (CYP1A2, CYP2E1, CYP2D22, CYP3A11).Conclusions: Our findings suggested that Que pretreatment could ameliorate LPS-induced liver injury.	Quercetin	13-16	nuclear receptor subfamily 1, group I, member 2	Mus musculus	124-127
32253952-7	2020	Furthermore, Que carried out the hepatoprotective effect via regulation of the expression of nuclear orphan receptors (CAR, PXR) and cytochrome P450 enzymes (CYP1A2, CYP2E1, CYP2D22, CYP3A11).Conclusions: Our findings suggested that Que pretreatment could ameliorate LPS-induced liver injury.	Quercetin	13-16	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	158-164
32253952-7	2020	Furthermore, Que carried out the hepatoprotective effect via regulation of the expression of nuclear orphan receptors (CAR, PXR) and cytochrome P450 enzymes (CYP1A2, CYP2E1, CYP2D22, CYP3A11).Conclusions: Our findings suggested that Que pretreatment could ameliorate LPS-induced liver injury.	Quercetin	13-16	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	166-172
32253952-7	2020	Furthermore, Que carried out the hepatoprotective effect via regulation of the expression of nuclear orphan receptors (CAR, PXR) and cytochrome P450 enzymes (CYP1A2, CYP2E1, CYP2D22, CYP3A11).Conclusions: Our findings suggested that Que pretreatment could ameliorate LPS-induced liver injury.	Quercetin	13-16	cytochrome P450, family 2, subfamily d, polypeptide 22	Mus musculus	174-181
32253952-7	2020	Furthermore, Que carried out the hepatoprotective effect via regulation of the expression of nuclear orphan receptors (CAR, PXR) and cytochrome P450 enzymes (CYP1A2, CYP2E1, CYP2D22, CYP3A11).Conclusions: Our findings suggested that Que pretreatment could ameliorate LPS-induced liver injury.	Quercetin	13-16	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	183-190
32179074-5	2020	Thus, the nasogastric administration of quercetin attenuated the tracheal stenosis of the rabbit tracheal stenosis model, in addition to effectively reversing an increase in pro-fibrotic factors (VEGF, IL-6, TGF-beta, COL-1, and COL-3) and fibrotic signaling mediators (mTOR and AKT), as well as downregulating ATG5 of the rabbit tracheal stenosis model.	Quercetin	40-49	autophagy protein 5	Oryctolagus cuniculus	311-315
32279813-4	2020	In vitro and in vivo studies have demonstrated the therapeutic effect of Quercetin, a ubiquitous flavonoid widely distributed in plants, on neuropathy, by modulating the expression of NRF-2-dependent antioxidant responsive elements.	Quercetin	73-82	NFE2 like bZIP transcription factor 2	Rattus norvegicus	184-189
32179074-6	2020	SIGNIFICANCE: Quercetin exhibits anti-fibrotic activity by inhibiting pro-fibrotic factors and AKT/mTOR signaling pathway, in addition to activating autophagy activity.	Quercetin	14-23	AKT serine/threonine kinase 1	Homo sapiens	95-98
32179074-0	2020	Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-beta/AKT/mTOR signaling pathway.	Quercetin	26-35	protransforming growth factor alpha	Oryctolagus cuniculus	80-88
32179074-0	2020	Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-beta/AKT/mTOR signaling pathway.	Quercetin	26-35	AKT serine/threonine kinase 1	Homo sapiens	89-92
32179074-6	2020	SIGNIFICANCE: Quercetin exhibits anti-fibrotic activity by inhibiting pro-fibrotic factors and AKT/mTOR signaling pathway, in addition to activating autophagy activity.	Quercetin	14-23	serine/threonine-protein kinase mTOR	Oryctolagus cuniculus	99-103
32179074-0	2020	Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-beta/AKT/mTOR signaling pathway.	Quercetin	26-35	serine/threonine-protein kinase mTOR	Oryctolagus cuniculus	93-97
32179074-3	2020	KEY FINDINGS: Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells.	Quercetin	33-42	interleukin 6	Homo sapiens	120-124
32179074-3	2020	KEY FINDINGS: Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells.	Quercetin	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	126-130
32179074-3	2020	KEY FINDINGS: Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells.	Quercetin	33-42	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	146-149
32179074-3	2020	KEY FINDINGS: Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells.	Quercetin	33-42	mechanistic target of rapamycin kinase	Homo sapiens	185-189
32492961-0	2020	Quercetin Inhibits Lef1 and Resensitizes Docetaxel-Resistant Breast Cancer Cells.	Quercetin	0-9	lymphoid enhancer binding factor 1	Homo sapiens	19-23
32179074-3	2020	KEY FINDINGS: Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells.	Quercetin	33-42	AKT serine/threonine kinase 1	Homo sapiens	194-197
32179074-3	2020	KEY FINDINGS: Pre-treatment with quercetin significantly reversed the LPS-induced upregulation of pro-fibrotic factors (IL-6, IL-8, COL-1, COL-3, LC3) and fibrotic signaling mediators (mTOR and AKT), and it induced the downregulation of ATG5 in the WI-38 cells.	Quercetin	33-42	autophagy related 5	Homo sapiens	237-241
32179074-5	2020	Thus, the nasogastric administration of quercetin attenuated the tracheal stenosis of the rabbit tracheal stenosis model, in addition to effectively reversing an increase in pro-fibrotic factors (VEGF, IL-6, TGF-beta, COL-1, and COL-3) and fibrotic signaling mediators (mTOR and AKT), as well as downregulating ATG5 of the rabbit tracheal stenosis model.	Quercetin	40-49	vascular endothelial growth factor A	Oryctolagus cuniculus	196-200
32179074-5	2020	Thus, the nasogastric administration of quercetin attenuated the tracheal stenosis of the rabbit tracheal stenosis model, in addition to effectively reversing an increase in pro-fibrotic factors (VEGF, IL-6, TGF-beta, COL-1, and COL-3) and fibrotic signaling mediators (mTOR and AKT), as well as downregulating ATG5 of the rabbit tracheal stenosis model.	Quercetin	40-49	interleukin-6	Oryctolagus cuniculus	202-206
32179074-5	2020	Thus, the nasogastric administration of quercetin attenuated the tracheal stenosis of the rabbit tracheal stenosis model, in addition to effectively reversing an increase in pro-fibrotic factors (VEGF, IL-6, TGF-beta, COL-1, and COL-3) and fibrotic signaling mediators (mTOR and AKT), as well as downregulating ATG5 of the rabbit tracheal stenosis model.	Quercetin	40-49	protransforming growth factor alpha	Oryctolagus cuniculus	208-216
32179074-5	2020	Thus, the nasogastric administration of quercetin attenuated the tracheal stenosis of the rabbit tracheal stenosis model, in addition to effectively reversing an increase in pro-fibrotic factors (VEGF, IL-6, TGF-beta, COL-1, and COL-3) and fibrotic signaling mediators (mTOR and AKT), as well as downregulating ATG5 of the rabbit tracheal stenosis model.	Quercetin	40-49	serine/threonine-protein kinase mTOR	Oryctolagus cuniculus	270-274
32179074-5	2020	Thus, the nasogastric administration of quercetin attenuated the tracheal stenosis of the rabbit tracheal stenosis model, in addition to effectively reversing an increase in pro-fibrotic factors (VEGF, IL-6, TGF-beta, COL-1, and COL-3) and fibrotic signaling mediators (mTOR and AKT), as well as downregulating ATG5 of the rabbit tracheal stenosis model.	Quercetin	40-49	AKT serine/threonine kinase 1	Homo sapiens	279-282
32350998-0	2020	The Ability of Quercetin and Ferulic Acid to Lower Stored Fat is Dependent on the Metabolic Background of Human Adipocytes.	Quercetin	15-24	FAT atypical cadherin 1	Homo sapiens	58-61
32350998-5	2020	RESULTS: In the "lipid storage state", a longer-term treatment (3 doses over 72 h) with low concentrations of quercetin and ferulic acid together significantly lowered stored lipid content, modified lipid composition and modulated genes related to lipid metabolism with a strong implication of PPARalpha/RXRalpha involvement.	Quercetin	110-119	peroxisome proliferator activated receptor alpha	Homo sapiens	294-303
32350998-5	2020	RESULTS: In the "lipid storage state", a longer-term treatment (3 doses over 72 h) with low concentrations of quercetin and ferulic acid together significantly lowered stored lipid content, modified lipid composition and modulated genes related to lipid metabolism with a strong implication of PPARalpha/RXRalpha involvement.	Quercetin	110-119	retinoid X receptor alpha	Homo sapiens	304-312
32492961-7	2020	Here, we confirmed that Lef1 inhibition, especially on treatment with the small molecule quercetin, decreased the expression of Lef1 and resensitized cells to docetaxel.	Quercetin	89-98	lymphoid enhancer binding factor 1	Homo sapiens	24-28
32492961-7	2020	Here, we confirmed that Lef1 inhibition, especially on treatment with the small molecule quercetin, decreased the expression of Lef1 and resensitized cells to docetaxel.	Quercetin	89-98	lymphoid enhancer binding factor 1	Homo sapiens	128-132
32200044-0	2020	Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer"s disease.	Quercetin	0-9	transferrin	Homo sapiens	50-61
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	Quercetin	54-63	angiotensin converting enzyme 2	Homo sapiens	161-165
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	Quercetin	54-63	angiotensin converting enzyme 2	Homo sapiens	210-214
32200044-1	2020	Quercetin was encapsulated in lipid nanoparticles (SLN and NLC) to take advantage of its neuroprotective properties in Alzheimer"s disease.	Quercetin	0-9	sarcolipin	Homo sapiens	51-54
32456069-8	2020	As rutin (quercetin-3-O-rutinose) was abundantly present in EAE and free quercetin was able to induce defensive antioxidant enzymes in an Nrf2-dependent manner, our findings suggested that quercetin derived from rutin via the intestinal microflora played a significant role in the protection of the mouse hippocampus from scopolamine-induced damage through BDNF-mediated Nrf2 activation, thereby dampening cognitive decline.	Quercetin	73-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142
32509050-9	2020	The IL-8 level was suppressed more significantly by quercetin metabolites in the perfusion co-culture, as compared to static culture.	Quercetin	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
32456069-8	2020	As rutin (quercetin-3-O-rutinose) was abundantly present in EAE and free quercetin was able to induce defensive antioxidant enzymes in an Nrf2-dependent manner, our findings suggested that quercetin derived from rutin via the intestinal microflora played a significant role in the protection of the mouse hippocampus from scopolamine-induced damage through BDNF-mediated Nrf2 activation, thereby dampening cognitive decline.	Quercetin	73-82	brain derived neurotrophic factor	Mus musculus	357-361
32456069-8	2020	As rutin (quercetin-3-O-rutinose) was abundantly present in EAE and free quercetin was able to induce defensive antioxidant enzymes in an Nrf2-dependent manner, our findings suggested that quercetin derived from rutin via the intestinal microflora played a significant role in the protection of the mouse hippocampus from scopolamine-induced damage through BDNF-mediated Nrf2 activation, thereby dampening cognitive decline.	Quercetin	73-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	371-375
31972553-2	2020	Polyphenols, including curcumin, procyanidin and quercetin etc., have showed great calcification inhibition potential in crosslinking collagen and elastin scaffolds.	Quercetin	49-58	elastin	Bos taurus	147-154
32455780-5	2020	Oral supplementation with quercetin increased glutathione peroxidase (GSH) levels, superoxidedismutase (SOD) activity and catalase (CAT) in the brain, and it reduced lipid peroxidation in AFB1-treated mice.	Quercetin	26-35	catalase	Mus musculus	122-130
32455780-5	2020	Oral supplementation with quercetin increased glutathione peroxidase (GSH) levels, superoxidedismutase (SOD) activity and catalase (CAT) in the brain, and it reduced lipid peroxidation in AFB1-treated mice.	Quercetin	26-35	catalase	Mus musculus	132-135
32142880-5	2020	In this study, we investigated the cytotoxicity and prooxidant profile of synthetic conjugate of two electrophilic compounds, quercetin and 1,4-naphthoquinone, 4"-O-(2-chloro-1,4-naphthoquinone-3-yloxy) quercetin (CHNQ), and its attenuation of inflammatory responses and modulation of Nrf2 pathway in BV-2 microglial cells.	Quercetin	126-135	nuclear factor, erythroid derived 2, like 2	Mus musculus	285-289
32430735-10	2020	In contrast, Bet v 1 and hazelnut Cor a 1 showed very similar binding behavior towards other flavonoids such as quercetin, genistein, apigenin, daidzein, and resveratrol.	Quercetin	112-121	delta/notch like EGF repeat containing	Homo sapiens	13-16
32410385-7	2020	Simultaneously, the expressions of StAR and P450scc were increased when treated with Que +H2 O2 , compared with the group treated with only H2 O2 (P < .05).	Quercetin	85-88	steroidogenic acute regulatory protein	Homo sapiens	35-39
32410385-7	2020	Simultaneously, the expressions of StAR and P450scc were increased when treated with Que +H2 O2 , compared with the group treated with only H2 O2 (P < .05).	Quercetin	85-88	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	44-51
32509200-0	2020	Quercetin stimulates osteogenic differentiation of bone marrow stromal cells through miRNA-206/connexin 43 pathway.	Quercetin	0-9	microRNA 206	Homo sapiens	85-94
32509200-0	2020	Quercetin stimulates osteogenic differentiation of bone marrow stromal cells through miRNA-206/connexin 43 pathway.	Quercetin	0-9	gap junction protein alpha 1	Homo sapiens	95-106
32509200-7	2020	We observed quercetin significantly elevated bone mineralization and the mRNA expression levels of osteoblast-specific genes including Runt-related transcription factor 2 (Runx2), Osterix (OSX), osteocalcin (OCN), and osteopontin (OPN).	Quercetin	12-21	RUNX family transcription factor 2	Homo sapiens	135-170
32509200-7	2020	We observed quercetin significantly elevated bone mineralization and the mRNA expression levels of osteoblast-specific genes including Runt-related transcription factor 2 (Runx2), Osterix (OSX), osteocalcin (OCN), and osteopontin (OPN).	Quercetin	12-21	RUNX family transcription factor 2	Homo sapiens	172-177
32509200-7	2020	We observed quercetin significantly elevated bone mineralization and the mRNA expression levels of osteoblast-specific genes including Runt-related transcription factor 2 (Runx2), Osterix (OSX), osteocalcin (OCN), and osteopontin (OPN).	Quercetin	12-21	Sp7 transcription factor	Homo sapiens	180-187
32509200-7	2020	We observed quercetin significantly elevated bone mineralization and the mRNA expression levels of osteoblast-specific genes including Runt-related transcription factor 2 (Runx2), Osterix (OSX), osteocalcin (OCN), and osteopontin (OPN).	Quercetin	12-21	Sp7 transcription factor	Homo sapiens	189-192
32509200-7	2020	We observed quercetin significantly elevated bone mineralization and the mRNA expression levels of osteoblast-specific genes including Runt-related transcription factor 2 (Runx2), Osterix (OSX), osteocalcin (OCN), and osteopontin (OPN).	Quercetin	12-21	bone gamma-carboxyglutamate protein	Homo sapiens	195-206
32509200-7	2020	We observed quercetin significantly elevated bone mineralization and the mRNA expression levels of osteoblast-specific genes including Runt-related transcription factor 2 (Runx2), Osterix (OSX), osteocalcin (OCN), and osteopontin (OPN).	Quercetin	12-21	bone gamma-carboxyglutamate protein	Homo sapiens	208-211
32509200-7	2020	We observed quercetin significantly elevated bone mineralization and the mRNA expression levels of osteoblast-specific genes including Runt-related transcription factor 2 (Runx2), Osterix (OSX), osteocalcin (OCN), and osteopontin (OPN).	Quercetin	12-21	secreted phosphoprotein 1	Homo sapiens	218-229
32509200-7	2020	We observed quercetin significantly elevated bone mineralization and the mRNA expression levels of osteoblast-specific genes including Runt-related transcription factor 2 (Runx2), Osterix (OSX), osteocalcin (OCN), and osteopontin (OPN).	Quercetin	12-21	secreted phosphoprotein 1	Homo sapiens	231-234
32509200-9	2020	In the presence of agomir of miR-206, effects of quercetin on mineralization, alkaline phosphatase activity and osteoblast-specific genes expression were suppressed.	Quercetin	49-58	microRNA 206	Homo sapiens	29-36
32509200-9	2020	In the presence of agomir of miR-206, effects of quercetin on mineralization, alkaline phosphatase activity and osteoblast-specific genes expression were suppressed.	Quercetin	49-58	alkaline phosphatase, placental	Homo sapiens	78-98
32509200-10	2020	Most of all, Cx43 protein level was also blocked while overexpression of miR-206 against quercetin effects.	Quercetin	89-98	microRNA 206	Homo sapiens	73-80
32509200-12	2020	The osteogenic effect of quercetin is partly modulated through miR-206/Cx43 pathway.	Quercetin	25-34	microRNA 206	Homo sapiens	63-70
32509200-12	2020	The osteogenic effect of quercetin is partly modulated through miR-206/Cx43 pathway.	Quercetin	25-34	gap junction protein alpha 1	Homo sapiens	71-75
32670552-7	2020	The comparative molecular docking analyses of CYP450 monooxygenase (CYP15A1, CYP6BR1, CYP6BK2, CYP6BK3) family were performed with quercetin, paraoxon and tetraethyl pyrophosphate which revealed considerable molecular interactions, predicting the inhibition of CYP450 isoenzyme by all three ligands.	Quercetin	131-140	cytochrome P450 15A1	Tribolium castaneum	68-75
32670552-7	2020	The comparative molecular docking analyses of CYP450 monooxygenase (CYP15A1, CYP6BR1, CYP6BK2, CYP6BK3) family were performed with quercetin, paraoxon and tetraethyl pyrophosphate which revealed considerable molecular interactions, predicting the inhibition of CYP450 isoenzyme by all three ligands.	Quercetin	131-140	cytochrome P450 6a2	Tribolium castaneum	77-84
32670552-7	2020	The comparative molecular docking analyses of CYP450 monooxygenase (CYP15A1, CYP6BR1, CYP6BK2, CYP6BK3) family were performed with quercetin, paraoxon and tetraethyl pyrophosphate which revealed considerable molecular interactions, predicting the inhibition of CYP450 isoenzyme by all three ligands.	Quercetin	131-140	probable cytochrome P450 6a14	Tribolium castaneum	86-93
32670552-7	2020	The comparative molecular docking analyses of CYP450 monooxygenase (CYP15A1, CYP6BR1, CYP6BK2, CYP6BK3) family were performed with quercetin, paraoxon and tetraethyl pyrophosphate which revealed considerable molecular interactions, predicting the inhibition of CYP450 isoenzyme by all three ligands.	Quercetin	131-140	probable cytochrome P450 6a13	Tribolium castaneum	95-102
32431618-0	2020	Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis via Inhibition of HMGB1.	Quercetin	0-9	galanin and GMAP prepropeptide	Homo sapiens	23-27
32431618-0	2020	Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis via Inhibition of HMGB1.	Quercetin	0-9	high mobility group box 1	Homo sapiens	130-135
32431618-4	2020	Quercetin (Que), as an antioxidant, is a potential phytochemical with hepatocyte protection and is also considered to be an inhibitor of HMGB1.	Quercetin	0-9	high mobility group box 1	Homo sapiens	137-142
31804760-0	2020	Quercetin alleviates lipopolysaccharide-induced inflammatory responses by up-regulation miR-124 in human renal tubular epithelial cell line HK-2.	Quercetin	0-9	hexokinase 2	Homo sapiens	140-144
32431618-4	2020	Quercetin (Que), as an antioxidant, is a potential phytochemical with hepatocyte protection and is also considered to be an inhibitor of HMGB1.	Quercetin	0-3	high mobility group box 1	Homo sapiens	137-142
32431618-6	2020	The present study explored whether the hepatoprotective effect of Que antagonizes HMGB1, and subsequent molecular signaling events.	Quercetin	66-69	high mobility group box 1	Homo sapiens	82-87
32431618-10	2020	When co-treated with Que, the expression of HMGB1 was decreased significantly, the expression of proteins in the corresponding signal pathway were further reduced, and the production of ROS and apoptosis were further suppressed.	Quercetin	21-24	high mobility group box 1	Homo sapiens	44-49
32431618-12	2020	Taken together, these results indicate that Que significantly improves d-GaLN-induced cellular damage by inhibiting oxidative stress and mitochondrial apoptosis via inhibiting HMGB1.	Quercetin	44-47	galanin and GMAP prepropeptide	Homo sapiens	73-77
32431618-12	2020	Taken together, these results indicate that Que significantly improves d-GaLN-induced cellular damage by inhibiting oxidative stress and mitochondrial apoptosis via inhibiting HMGB1.	Quercetin	44-47	high mobility group box 1	Homo sapiens	176-181
32454852-6	2020	HPLC analysis revealed AVEE contained quercetin, a possible activator of the Nrf2/HO-1 pathway.	Quercetin	38-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
32454852-6	2020	HPLC analysis revealed AVEE contained quercetin, a possible activator of the Nrf2/HO-1 pathway.	Quercetin	38-47	heme oxygenase 1	Mus musculus	82-86
31804760-4	2020	HK-2 cells were preprocessed by Quercetin and then irritated with lipopolysaccharide (LPS).	Quercetin	32-41	hexokinase 2	Homo sapiens	0-4
31804760-12	2020	Meanwhile, Quercetin attenuated LPS-stimulated apoptosis, production of IL-6, and TNF-alpha in experimental cells.	Quercetin	11-20	interleukin 6	Homo sapiens	72-76
31804760-12	2020	Meanwhile, Quercetin attenuated LPS-stimulated apoptosis, production of IL-6, and TNF-alpha in experimental cells.	Quercetin	11-20	tumor necrosis factor	Homo sapiens	82-91
31804760-13	2020	Subsequently, MyD88 and miR-124 expression was elevated by LPS and alleviated by Quercetin.	Quercetin	81-90	MYD88 innate immune signal transduction adaptor	Homo sapiens	14-19
32007919-0	2020	Quercetin promotes the survival of granulocytic myeloid-derived suppressor cells via the ESR2/STAT3 signaling pathway.	Quercetin	0-9	estrogen receptor 2	Homo sapiens	89-93
32007919-0	2020	Quercetin promotes the survival of granulocytic myeloid-derived suppressor cells via the ESR2/STAT3 signaling pathway.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	94-99
31804760-15	2020	Our data demonstrated that Quercetin reduced apoptosis and inflammation stimulated by LPS in HK-2 cells.	Quercetin	27-36	hexokinase 2	Homo sapiens	93-97
32357811-3	2020	In thecase of MAO-B the rhamnetin, quercetin, piperine, eugenol,and umbelliferone exhibited highest dock score -10.57, -9.938, -9.445, - 8.757and 7.821respectively.	Quercetin	35-44	monoamine oxidase B	Homo sapiens	14-19
32066042-6	2020	Quercetin upregulated IFN-alpha and IFN-beta expression through activating RIG-I promoter in B16 cells.	Quercetin	0-9	interferon alpha	Mus musculus	22-31
32066042-6	2020	Quercetin upregulated IFN-alpha and IFN-beta expression through activating RIG-I promoter in B16 cells.	Quercetin	0-9	interferon alpha	Mus musculus	36-44
32066042-6	2020	Quercetin upregulated IFN-alpha and IFN-beta expression through activating RIG-I promoter in B16 cells.	Quercetin	0-9	DEAD/H box helicase 58	Mus musculus	75-80
32066042-9	2020	Our study provided novel insights regarding biological and anti-proliferative activities of quercetin against melanoma, and we identified RIG-I as a potential target in anti-tumor therapies.	Quercetin	92-101	DEAD/H box helicase 58	Mus musculus	138-143
32357811-4	2020	In the case of MAO-A umbelliferone, curcumin, caffeic acid, quercetin possessed dock score -8.001, -7.941, -7.357, -6.658 respectively.	Quercetin	60-69	monoamine oxidase A	Homo sapiens	15-20
32391533-7	2020	Finally, in vitro evaluation of the components of BSO demonstrated that the anti-adipogenic activity of quercetin was significantly potentiated by the combination with both LA and GLA through the down-regulation of different adipogenesis-key genes in 3T3-L1 cells.	Quercetin	104-113	galactosidase, alpha	Mus musculus	180-183
32266013-7	2020	Compared with the model group, rats pretreated with fisetin, quercetin and aspirin showed significant prolongation of clotting time, prothrombin time, thrombin time and activated partial thromboplastin time.	Quercetin	61-70	coagulation factor II	Rattus norvegicus	136-144
32247463-6	2020	Caco-2 cell viability was not affected up to 21 x 10-3 mg mL-1 of riboflavin and 16 x 10-3 mg mL-1 quercetin on beta-Lg micro- and nanostructures.	Quercetin	99-108	L1 cell adhesion molecule	Mus musculus	94-98
32363357-7	2020	Quercetin added apically to the endothelial cells upregulated HO-1 and downregulated PDK4 both in monoculture and in co-culture, but the total PDK4 levels were higher in the presence of HepG2 cells.	Quercetin	0-9	heme oxygenase 1	Homo sapiens	62-66
32363357-7	2020	Quercetin added apically to the endothelial cells upregulated HO-1 and downregulated PDK4 both in monoculture and in co-culture, but the total PDK4 levels were higher in the presence of HepG2 cells.	Quercetin	0-9	pyruvate dehydrogenase kinase 4	Homo sapiens	85-89
32363357-7	2020	Quercetin added apically to the endothelial cells upregulated HO-1 and downregulated PDK4 both in monoculture and in co-culture, but the total PDK4 levels were higher in the presence of HepG2 cells.	Quercetin	0-9	pyruvate dehydrogenase kinase 4	Homo sapiens	143-147
32027086-0	2020	Quercetin radiosensitizes non-small cell lung cancer cells through the regulation of miR-16-5p/WEE1 axis.	Quercetin	0-9	WEE1 G2 checkpoint kinase	Homo sapiens	95-99
32061704-1	2020	The biophysical aspects of the binding interaction between a phytoestrogen (quercetin, QT) and bone morphogenetic protein - 2 (BMP - 2) was analyzed by various spectroscopic, calorimetric and molecular docking techniques.	Quercetin	76-85	bone morphogenetic protein 2	Homo sapiens	95-125
32061704-1	2020	The biophysical aspects of the binding interaction between a phytoestrogen (quercetin, QT) and bone morphogenetic protein - 2 (BMP - 2) was analyzed by various spectroscopic, calorimetric and molecular docking techniques.	Quercetin	76-85	bone morphogenetic protein 2	Homo sapiens	127-134
32061704-9	2020	All these investigations confirmed a significant effect on the structure and conformation of BMP - 2 in presence of quercetin which might serve as a potential therapeutic for the treatment of osteoporosis in postmenopausal women.	Quercetin	116-125	bone morphogenetic protein 2	Homo sapiens	93-100
32027086-9	2020	Furthermore, quercetin treatment increased the expression of miR-16-5p and decreased the expression of WEE1.	Quercetin	13-22	WEE1 G2 checkpoint kinase	Homo sapiens	103-107
32027086-10	2020	The function of quercetin was reversed by miR-16-5p inhibitors or the transfection of WEE1 overexpressing plasmids.	Quercetin	16-25	WEE1 G2 checkpoint kinase	Homo sapiens	86-90
32027086-11	2020	CONCLUSION: In conclusion, quercetin enhanced the radiosensitivity of NSCLC cells via modulating the expression of miR-16-5p and WEE1.	Quercetin	27-36	WEE1 G2 checkpoint kinase	Homo sapiens	129-133
31960917-0	2020	Quercetin attenuates high glucose induced injury in human retinal pigment epithelial cell line ARPE-19 by up-regulation of miR-29b.	Quercetin	0-9	microRNA 29b-1	Homo sapiens	123-130
31960917-5	2020	The association between quercetin and miR-29b expression as well as the downstream pathways was studied by qRT-PCR and western blot.	Quercetin	24-33	microRNA 29b-1	Homo sapiens	38-45
32145471-9	2020	Q and quercetin 3-glucoronide prevented TNFalpha-mediated downregulation of adipogenesis during 3T3-L1 pre-adipocytes early differentiation.	Quercetin	0-1	tumor necrosis factor	Rattus norvegicus	40-48
31960917-6	2020	Pre-treating ARPE-19 cells with quercetin clearly attenuated high glucose-induced viability loss, apoptosis, MCP-1 and IL-6 overproduction, and ROS generation.	Quercetin	32-41	C-C motif chemokine ligand 2	Homo sapiens	109-114
31960917-6	2020	Pre-treating ARPE-19 cells with quercetin clearly attenuated high glucose-induced viability loss, apoptosis, MCP-1 and IL-6 overproduction, and ROS generation.	Quercetin	32-41	interleukin 6	Homo sapiens	119-123
31960917-7	2020	Quercetin down-regulated p53, Bax and cleaved-caspase-3 expression, while up-regulated CyclinD1, CDK4 and Bcl-2.	Quercetin	0-9	tumor protein p53	Homo sapiens	25-28
31960917-7	2020	Quercetin down-regulated p53, Bax and cleaved-caspase-3 expression, while up-regulated CyclinD1, CDK4 and Bcl-2.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	30-33
31960917-7	2020	Quercetin down-regulated p53, Bax and cleaved-caspase-3 expression, while up-regulated CyclinD1, CDK4 and Bcl-2.	Quercetin	0-9	cyclin D1	Homo sapiens	87-95
31960917-7	2020	Quercetin down-regulated p53, Bax and cleaved-caspase-3 expression, while up-regulated CyclinD1, CDK4 and Bcl-2.	Quercetin	0-9	cyclin dependent kinase 4	Homo sapiens	97-101
31960917-7	2020	Quercetin down-regulated p53, Bax and cleaved-caspase-3 expression, while up-regulated CyclinD1, CDK4 and Bcl-2.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	106-111
31960917-9	2020	Moreover, the protective action of quercetin towards ARPE-19 cells was attenuated when miR-29b was suppressed.	Quercetin	35-44	microRNA 29b-1	Homo sapiens	87-94
31960917-10	2020	Also, quercetin promoted PTEN/AKT pathway while inhibited NF-kappaB pathway via a miR-29b-dependent way.	Quercetin	6-15	phosphatase and tensin homolog	Homo sapiens	25-29
31960917-10	2020	Also, quercetin promoted PTEN/AKT pathway while inhibited NF-kappaB pathway via a miR-29b-dependent way.	Quercetin	6-15	AKT serine/threonine kinase 1	Homo sapiens	30-33
31960917-10	2020	Also, quercetin promoted PTEN/AKT pathway while inhibited NF-kappaB pathway via a miR-29b-dependent way.	Quercetin	6-15	microRNA 29b-1	Homo sapiens	82-89
31960917-12	2020	The protective action of quercetin may due to its regulation on miR-29b expression as well as PTEN/AKT and NF-kappaB pathways.	Quercetin	25-34	microRNA 29b-1	Homo sapiens	64-71
31960917-12	2020	The protective action of quercetin may due to its regulation on miR-29b expression as well as PTEN/AKT and NF-kappaB pathways.	Quercetin	25-34	phosphatase and tensin homolog	Homo sapiens	94-98
31960917-12	2020	The protective action of quercetin may due to its regulation on miR-29b expression as well as PTEN/AKT and NF-kappaB pathways.	Quercetin	25-34	AKT serine/threonine kinase 1	Homo sapiens	99-102
32088935-12	2020	Expression of the Caspase3 gene increased dramatically in the collected blastocysts from diabetic mice and reduced following quercetin treatment.	Quercetin	125-134	caspase 3	Mus musculus	18-26
32088935-13	2020	Besides, the inactive beta-catenin protein level in the blastocysts of diabetic mice was higher than that in normal mice, while treatment with quercetin decreased the level of inactive beta-catenin protein in the blastocyst of diabetic mice.	Quercetin	143-152	catenin (cadherin associated protein), beta 1	Mus musculus	22-34
32088935-13	2020	Besides, the inactive beta-catenin protein level in the blastocysts of diabetic mice was higher than that in normal mice, while treatment with quercetin decreased the level of inactive beta-catenin protein in the blastocyst of diabetic mice.	Quercetin	143-152	catenin (cadherin associated protein), beta 1	Mus musculus	185-197
32566207-12	2020	In addition, aucubin, quercetin, and kaempferol ameliorated VEGF-induced retinal vascular leakage.	Quercetin	22-31	vascular endothelial growth factor A	Mus musculus	60-64
31836917-0	2020	Resveratrol and quercetin attenuate depressive-like behavior and restore impaired contractility of vas deferens in chronic stress-exposed rats: involvement of oxidative stress and inflammation.	Quercetin	16-25	arginine vasopressin	Rattus norvegicus	99-102
31836917-2	2020	The aim of this study was to determine whether resveratrol (RS) or quercetin (QE) has protective effects on vas deferens (VD) contractility in the unpredictable chronic mild stress (UCMS) rat model of depression.	Quercetin	67-76	arginine vasopressin	Rattus norvegicus	108-111
31836917-2	2020	The aim of this study was to determine whether resveratrol (RS) or quercetin (QE) has protective effects on vas deferens (VD) contractility in the unpredictable chronic mild stress (UCMS) rat model of depression.	Quercetin	78-80	arginine vasopressin	Rattus norvegicus	108-111
32349726-9	2020	Upon bleomycin treatment, quercetin-fed mice displayed reduced expression of collagen (COL1A2) and fibronectin (FN1) and a tendency of reduced inflammatory lesions (2.8 +- 0.7 versus 1.9 +- 0.8).	Quercetin	26-35	collagen, type I, alpha 2	Mus musculus	77-93
32349726-4	2020	Quercetin is a dietary antioxidant with strong redox modulating capacities that is suggested to exert part of its antioxidative effects via activation of the redox-sensitive transcription factor Nrf2 that regulates endogenous antioxidant levels.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	195-199
32349726-5	2020	Therefore, the aim of the present study was to investigate if the dietary antioxidant quercetin can exert anti-fibrotic effects in a mouse model of bleomycin-induced pulmonary fibrogenesis through Nrf2-dependent restoration of redox imbalance.	Quercetin	86-95	nuclear factor, erythroid derived 2, like 2	Mus musculus	197-201
32349726-9	2020	Upon bleomycin treatment, quercetin-fed mice displayed reduced expression of collagen (COL1A2) and fibronectin (FN1) and a tendency of reduced inflammatory lesions (2.8 +- 0.7 versus 1.9 +- 0.8).	Quercetin	26-35	fibronectin 1	Mus musculus	99-110
32349726-9	2020	Upon bleomycin treatment, quercetin-fed mice displayed reduced expression of collagen (COL1A2) and fibronectin (FN1) and a tendency of reduced inflammatory lesions (2.8 +- 0.7 versus 1.9 +- 0.8).	Quercetin	26-35	fibronectin 1	Mus musculus	112-115
32349726-12	2020	CONCLUSION: Quercetin exerts anti-fibrogenic and anti-inflammatory effects on bleomycin-induced pulmonary damage in mice possibly through modulation of the redox balance by inducing Nrf2.	Quercetin	12-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	182-186
32357395-0	2020	Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats.	Quercetin	0-9	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	25-57
32419805-6	2020	QUER administration significantly reduced inflammatory markers such as interleukin-6, interleukin-1beta, cyclooxygenase-2, and nuclear factor-kappaB levels in the brain.	Quercetin	0-4	interleukin 6	Rattus norvegicus	71-84
32419805-6	2020	QUER administration significantly reduced inflammatory markers such as interleukin-6, interleukin-1beta, cyclooxygenase-2, and nuclear factor-kappaB levels in the brain.	Quercetin	0-4	interleukin 1 beta	Rattus norvegicus	86-103
32419805-6	2020	QUER administration significantly reduced inflammatory markers such as interleukin-6, interleukin-1beta, cyclooxygenase-2, and nuclear factor-kappaB levels in the brain.	Quercetin	0-4	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	105-121
32420373-11	2020	Quercetin could increase the survival rate and proliferation rate of PC12 cells; reduce the levels of LDH, AChE, MDA, and HO-1 protein; and increase the levels of SOD, GSH-Px, CAT, T-AOC, sirtuin1, and Nrf2 protein.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	122-126
32420373-11	2020	Quercetin could increase the survival rate and proliferation rate of PC12 cells; reduce the levels of LDH, AChE, MDA, and HO-1 protein; and increase the levels of SOD, GSH-Px, CAT, T-AOC, sirtuin1, and Nrf2 protein.	Quercetin	0-9	catalase	Rattus norvegicus	176-179
32420373-11	2020	Quercetin could increase the survival rate and proliferation rate of PC12 cells; reduce the levels of LDH, AChE, MDA, and HO-1 protein; and increase the levels of SOD, GSH-Px, CAT, T-AOC, sirtuin1, and Nrf2 protein.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	188-196
32420373-11	2020	Quercetin could increase the survival rate and proliferation rate of PC12 cells; reduce the levels of LDH, AChE, MDA, and HO-1 protein; and increase the levels of SOD, GSH-Px, CAT, T-AOC, sirtuin1, and Nrf2 protein.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	202-206
32420373-12	2020	Conclusion: Quercetin can increase the survival rate of PC12 injured by Abeta 25-35, promote cell proliferation, and antagonize the toxicity of Abeta; it also has certain neuroprotective effects.	Quercetin	12-21	amyloid beta precursor protein	Rattus norvegicus	72-77
32410992-7	2020	Quercetin administration decreased lipid deposition in arterial lumina, serum sIcam-1, and IL-6 and Vcam-1 in aorta, while increased the density of Sirt1 in aorta of ApoE-/- mice.	Quercetin	0-9	interleukin 6	Mus musculus	91-95
32410992-7	2020	Quercetin administration decreased lipid deposition in arterial lumina, serum sIcam-1, and IL-6 and Vcam-1 in aorta, while increased the density of Sirt1 in aorta of ApoE-/- mice.	Quercetin	0-9	vascular cell adhesion molecule 1	Mus musculus	100-106
32410992-7	2020	Quercetin administration decreased lipid deposition in arterial lumina, serum sIcam-1, and IL-6 and Vcam-1 in aorta, while increased the density of Sirt1 in aorta of ApoE-/- mice.	Quercetin	0-9	sirtuin 1	Mus musculus	148-153
32410992-7	2020	Quercetin administration decreased lipid deposition in arterial lumina, serum sIcam-1, and IL-6 and Vcam-1 in aorta, while increased the density of Sirt1 in aorta of ApoE-/- mice.	Quercetin	0-9	apolipoprotein E	Mus musculus	166-170
32410992-11	2020	GO and KEGG analysis indicated nitrogen metabolism, ECM-receptor interaction, complement, and coagulation cascades, p53 and mTOR signaling pathway were involved in the pharmacological mechanisms of quercetin against ox-LDL.	Quercetin	198-207	transformation related protein 53, pseudogene	Mus musculus	116-119
32410992-11	2020	GO and KEGG analysis indicated nitrogen metabolism, ECM-receptor interaction, complement, and coagulation cascades, p53 and mTOR signaling pathway were involved in the pharmacological mechanisms of quercetin against ox-LDL.	Quercetin	198-207	mechanistic target of rapamycin kinase	Mus musculus	124-128
32420373-0	2020	Effect of Quercetin on PC12 Alzheimer"s Disease Cell Model Induced by Abeta 25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.	Quercetin	10-19	sirtuin 1	Rattus norvegicus	109-117
32420373-0	2020	Effect of Quercetin on PC12 Alzheimer"s Disease Cell Model Induced by Abeta 25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.	Quercetin	10-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	118-122
32420373-0	2020	Effect of Quercetin on PC12 Alzheimer"s Disease Cell Model Induced by Abeta 25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.	Quercetin	10-19	heme oxygenase 1	Rattus norvegicus	123-127
32420373-11	2020	Quercetin could increase the survival rate and proliferation rate of PC12 cells; reduce the levels of LDH, AChE, MDA, and HO-1 protein; and increase the levels of SOD, GSH-Px, CAT, T-AOC, sirtuin1, and Nrf2 protein.	Quercetin	0-9	acetylcholinesterase	Rattus norvegicus	107-111
32357395-1	2020	The potential inhibitory effect of quercetin, a major plant flavonol, on breast cancer resistance protein (BCRP) activity was investigated in this study.	Quercetin	35-44	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	73-105
32357395-1	2020	The potential inhibitory effect of quercetin, a major plant flavonol, on breast cancer resistance protein (BCRP) activity was investigated in this study.	Quercetin	35-44	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	107-111
32357395-2	2020	The presence of quercetin significantly increased the cellular accumulation and associated cytotoxicity of the BCRP substrate mitoxantrone in human cervical cancer cells (HeLa cells) in a concentration-dependent manner.	Quercetin	16-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	111-115
32357395-3	2020	The transcellular efflux of prazosin, a stereotypical BCRP substrate, was also significantly reduced in the presence of quercetin in a bidirectional transport assay using human BCRP-overexpressing cells; further kinetic analysis revealed IC50 and Ki values of 4.22 and 3.91 muM, respectively.	Quercetin	120-129	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	54-58
32357395-3	2020	The transcellular efflux of prazosin, a stereotypical BCRP substrate, was also significantly reduced in the presence of quercetin in a bidirectional transport assay using human BCRP-overexpressing cells; further kinetic analysis revealed IC50 and Ki values of 4.22 and 3.91 muM, respectively.	Quercetin	120-129	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	177-181
32357395-5	2020	Collectively, these results provide evidence that quercetin acts as an in vivo as well as in vitro inhibitor of BCRP.	Quercetin	50-59	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	112-116
31981747-11	2020	The in vitro studies showed that quercetin and ursolic acid, the active components of XJR, could effectively inhibit the proliferation of breast cancer cells, and the combination of the two components could significantly decrease the mitochondrial membrane potential and suppress the activation of PI3K-Akt signaling pathway, thus inducing apoptosis of cancer cells.	Quercetin	33-42	AKT serine/threonine kinase 1	Homo sapiens	303-306
32390844-6	2020	These effects may be related to the effect of quercetin on functional molecules in hUCMSCs, including nitric oxide (NO), indoleamine 2,3-dioxygenase (IDO), interleukin 6 (IL-6) and Toll-like receptor-3 (TLR-3) and the Akt/IkappaB pathways.	Quercetin	46-55	toll like receptor 3	Homo sapiens	181-208
32390844-6	2020	These effects may be related to the effect of quercetin on functional molecules in hUCMSCs, including nitric oxide (NO), indoleamine 2,3-dioxygenase (IDO), interleukin 6 (IL-6) and Toll-like receptor-3 (TLR-3) and the Akt/IkappaB pathways.	Quercetin	46-55	AKT serine/threonine kinase 1	Homo sapiens	218-221
32390844-0	2020	Quercetin Combined With Human Umbilical Cord Mesenchymal Stem Cells Regulated Tumour Necrosis Factor-alpha/Interferon-gamma-Stimulated Peripheral Blood Mononuclear Cells via Activation of Toll-Like Receptor 3 Signalling.	Quercetin	0-9	interferon gamma	Homo sapiens	107-123
32390844-0	2020	Quercetin Combined With Human Umbilical Cord Mesenchymal Stem Cells Regulated Tumour Necrosis Factor-alpha/Interferon-gamma-Stimulated Peripheral Blood Mononuclear Cells via Activation of Toll-Like Receptor 3 Signalling.	Quercetin	0-9	toll like receptor 3	Homo sapiens	188-208
32390844-7	2020	These results suggest that quercetin effectively promoted the immunoregulatory effect of hUCMSCs by inhibiting the Akt/IkappaB pathway, activating the Toll-like receptor-3 pathway, and regulating downstream cytokines.	Quercetin	27-36	AKT serine/threonine kinase 1	Homo sapiens	115-118
32390844-7	2020	These results suggest that quercetin effectively promoted the immunoregulatory effect of hUCMSCs by inhibiting the Akt/IkappaB pathway, activating the Toll-like receptor-3 pathway, and regulating downstream cytokines.	Quercetin	27-36	toll like receptor 3	Homo sapiens	151-171
32337383-0	2020	Modulation of Nrf2 by quercetin in doxorubicin-treated rats.	Quercetin	22-31	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
32312941-0	2020	Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mfice.	Quercetin	0-9	sirtuin 1	Mus musculus	54-59
32312941-4	2020	In this study, we used db/db mice to investigate whether quercetin could activate SIRT1 and inhibit ER pathways to improve DE.	Quercetin	57-66	sirtuin 1	Mus musculus	82-87
32312941-7	2020	Western blot analysis and Nissl staining showed that quercetin can improve the expression of nerve and synapse-associated proteins (PSD93, PSD95, NGF and BDNF) and inhibit neurodegeneration.	Quercetin	53-62	discs large MAGUK scaffold protein 2	Mus musculus	132-137
32312941-7	2020	Western blot analysis and Nissl staining showed that quercetin can improve the expression of nerve and synapse-associated proteins (PSD93, PSD95, NGF and BDNF) and inhibit neurodegeneration.	Quercetin	53-62	discs large MAGUK scaffold protein 4	Mus musculus	139-144
32312941-7	2020	Western blot analysis and Nissl staining showed that quercetin can improve the expression of nerve and synapse-associated proteins (PSD93, PSD95, NGF and BDNF) and inhibit neurodegeneration.	Quercetin	53-62	nerve growth factor	Mus musculus	146-149
32312941-7	2020	Western blot analysis and Nissl staining showed that quercetin can improve the expression of nerve and synapse-associated proteins (PSD93, PSD95, NGF and BDNF) and inhibit neurodegeneration.	Quercetin	53-62	brain derived neurotrophic factor	Mus musculus	154-158
32312941-8	2020	Meanwhile, quercetin up-regulates SIRT1 protein expression and inhibits the expression of ER signaling pathway-related proteins (PERK, IRE-1alpha, ATF6, eIF2alpha, BIP and PDI).	Quercetin	11-20	sirtuin 1	Mus musculus	34-39
32312941-8	2020	Meanwhile, quercetin up-regulates SIRT1 protein expression and inhibits the expression of ER signaling pathway-related proteins (PERK, IRE-1alpha, ATF6, eIF2alpha, BIP and PDI).	Quercetin	11-20	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	129-133
32312941-8	2020	Meanwhile, quercetin up-regulates SIRT1 protein expression and inhibits the expression of ER signaling pathway-related proteins (PERK, IRE-1alpha, ATF6, eIF2alpha, BIP and PDI).	Quercetin	11-20	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	135-145
32312941-8	2020	Meanwhile, quercetin up-regulates SIRT1 protein expression and inhibits the expression of ER signaling pathway-related proteins (PERK, IRE-1alpha, ATF6, eIF2alpha, BIP and PDI).	Quercetin	11-20	activating transcription factor 6	Mus musculus	147-151
32184034-12	2020	Our findings suggest that quercetin up-regulates IRGs, IFNalpha, and down-regulates TGFbeta mRNA expressions which may contribute to further reducing number of viremic pigs and HP-PRRSV viremia which were conferred by PRRSV-1 MLV vaccine.	Quercetin	26-35	interferon-alpha-14	Sus scrofa	55-63
32184034-12	2020	Our findings suggest that quercetin up-regulates IRGs, IFNalpha, and down-regulates TGFbeta mRNA expressions which may contribute to further reducing number of viremic pigs and HP-PRRSV viremia which were conferred by PRRSV-1 MLV vaccine.	Quercetin	26-35	transforming growth factor alpha	Sus scrofa	84-91
32337383-10	2020	Quercetin increased Nrf2 mRNA expression and reduced histological abnormalities compared to the DOXO control group.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	20-24
32312941-8	2020	Meanwhile, quercetin up-regulates SIRT1 protein expression and inhibits the expression of ER signaling pathway-related proteins (PERK, IRE-1alpha, ATF6, eIF2alpha, BIP and PDI).	Quercetin	11-20	eukaryotic translation initiation factor 2A	Mus musculus	153-162
32312941-8	2020	Meanwhile, quercetin up-regulates SIRT1 protein expression and inhibits the expression of ER signaling pathway-related proteins (PERK, IRE-1alpha, ATF6, eIF2alpha, BIP and PDI).	Quercetin	11-20	heat shock protein 5	Mus musculus	164-167
32337383-11	2020	In conclusion, quercetin protected against DOXO- induced cardiomyopathy, by increasing expression of NRF2, and thereby increasing antioxidant defense and restoring biochemical and histological abnormalities.	Quercetin	15-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-105
32308802-10	2020	Moreover, inhibition of Hsp70 by quercetin enhanced I/R-induced myocardial injury, while SB203580 pretreatment reversed the harmful effects caused by quercetin.	Quercetin	33-42	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	24-29
32312941-8	2020	Meanwhile, quercetin up-regulates SIRT1 protein expression and inhibits the expression of ER signaling pathway-related proteins (PERK, IRE-1alpha, ATF6, eIF2alpha, BIP and PDI).	Quercetin	11-20	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	172-175
32312941-10	2020	In conclusion, current experimental results indicated that SIRT1/ER stress is a promising mechanism involved in quercetin-treated diabetic encephalopathy.	Quercetin	112-121	sirtuin 1	Mus musculus	59-64
32208672-0	2020	Quercetin and baicalein act as a potent anti-amyloidogenic and fibril destabilizing agents for SOD1 fibrils.	Quercetin	0-9	superoxide dismutase 1	Homo sapiens	95-99
32208672-3	2020	Herein, we demonstrate the potential of two naturally occurring flavonoids (quercetin and baicalein) to inhibit fibrillation of wild type SOD1 with the aid of series of biophysical techniques.	Quercetin	76-85	superoxide dismutase 1	Homo sapiens	138-142
32208672-7	2020	Docking of these flavonoids with non- native monomer, non-native trimer and oligomer derived from 11 residues segment of SOD1 indicate that both quercetin and baicalein can bind to these species and thus, can arrest the elongation of fibrils by blocking the fibrillar core regions on the intermediate species formed during aggregation of SOD1.	Quercetin	145-154	superoxide dismutase 1	Homo sapiens	121-125
32208672-7	2020	Docking of these flavonoids with non- native monomer, non-native trimer and oligomer derived from 11 residues segment of SOD1 indicate that both quercetin and baicalein can bind to these species and thus, can arrest the elongation of fibrils by blocking the fibrillar core regions on the intermediate species formed during aggregation of SOD1.	Quercetin	145-154	superoxide dismutase 1	Homo sapiens	338-342
32351394-0	2020	Corrigendum: Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC.	Quercetin	13-22	brain-derived neurotrophic factor	Rattus norvegicus	94-98
32351394-0	2020	Corrigendum: Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC.	Quercetin	13-22	copine 6	Rattus norvegicus	120-128
32351394-0	2020	Corrigendum: Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC.	Quercetin	13-22	triggering receptor expressed on myeloid cells 1	Rattus norvegicus	133-140
32159961-2	2020	This work presents a combination strategy of pretreatment of MDA-MB-231/MDR1 cells with quercetin (QU) followed by doxorubicin (DOX) to overcome MDR, which can be delivered by mixed micelles composed of the reduction-sensitive hyaluronic acid-based conjugate and d-alpha-tocopheryl poly(ethylene glycol) 1000 succinate.	Quercetin	88-97	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	72-75
32309744-10	2020	Also, quercetin increased expression of the glutamate-cysteine ligase catalytic subunit (GCLC), the first rate-limiting enzyme of glutathione synthesis, and increased intracellular GSH concentration under H2O2 treatment.	Quercetin	6-15	glutamate-cysteine ligase catalytic subunit	Homo sapiens	44-87
32309744-10	2020	Also, quercetin increased expression of the glutamate-cysteine ligase catalytic subunit (GCLC), the first rate-limiting enzyme of glutathione synthesis, and increased intracellular GSH concentration under H2O2 treatment.	Quercetin	6-15	glutamate-cysteine ligase catalytic subunit	Homo sapiens	89-93
32309744-12	2020	These results indicated that quercetin can improve cell proliferation and increase intracellular GSH concentrations by upregulating transcription of GCLC to eliminate excessive reactive oxygen species (ROS).	Quercetin	29-38	glutamate-cysteine ligase catalytic subunit	Homo sapiens	149-153
32309744-13	2020	Increased extracellular H2O2 concentration induced by quercetin under oxidative stress was related to the inhibition of AQP3 and upregulation of NOX1/2, which may contribute to the observed protective effects of quercetin.	Quercetin	54-63	aquaporin 3 (Gill blood group)	Homo sapiens	120-124
32309744-13	2020	Increased extracellular H2O2 concentration induced by quercetin under oxidative stress was related to the inhibition of AQP3 and upregulation of NOX1/2, which may contribute to the observed protective effects of quercetin.	Quercetin	54-63	NADPH oxidase 1	Homo sapiens	145-151
32309744-13	2020	Increased extracellular H2O2 concentration induced by quercetin under oxidative stress was related to the inhibition of AQP3 and upregulation of NOX1/2, which may contribute to the observed protective effects of quercetin.	Quercetin	212-221	aquaporin 3 (Gill blood group)	Homo sapiens	120-124
32309744-13	2020	Increased extracellular H2O2 concentration induced by quercetin under oxidative stress was related to the inhibition of AQP3 and upregulation of NOX1/2, which may contribute to the observed protective effects of quercetin.	Quercetin	212-221	NADPH oxidase 1	Homo sapiens	145-151
32241517-0	2020	Quercetin improves immune function in Arbor Acre broilers through activation of NF-kappaB signaling pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	80-89
32182051-0	2020	Changes in Allergenicity of Ovalbumin in Vitro and in Vivo on Conjugation with Quercetin.	Quercetin	79-88	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	28-37
32065675-8	2020	This might be associated with that quercetin reduced cathepsin B, tau phosphorylation, and neuroinflammation, and elevated alpha-diversity index (ACE, Chao1, and Shannon index), and reduced phylum Verrucomicrobia of gut microbiota.	Quercetin	35-44	cathepsin B	Mus musculus	53-64
31853730-3	2020	Quercetin coordination complexes with the metal ions Cu+2, Zn+2, Ni+2, Co+2, and Fe+2 were synthesized to investigate their potential use against Alzheimer"s disease, by evaluating the inhibition of acetylcholinesterase in vitro and in silico, as well as the antioxidant activity, toxicity, and anxiolytic action in the zebrafish (Danio rerio) model.	Quercetin	0-9	acetylcholinesterase	Danio rerio	199-219
32276890-4	2020	Quercetin also reduced mRNA and protein levels of fibronectin in myometrial cells (P < 0.05) and fibronectin protein in leiomyoma cells (P < 0.05).	Quercetin	0-9	fibronectin 1	Homo sapiens	50-61
32032576-0	2020	Quercetin suppresses the migration of hepatocellular carcinoma cells stimulated by hepatocyte growth factor or transforming growth factor-alpha: Attenuation of AKT signaling pathway.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	111-143
32032576-0	2020	Quercetin suppresses the migration of hepatocellular carcinoma cells stimulated by hepatocyte growth factor or transforming growth factor-alpha: Attenuation of AKT signaling pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	160-163
32032576-5	2020	In this study, we investigated whether quercetin affects the HGF- or TGF-alpha induced migration of HuH7 cells.	Quercetin	39-48	hepatocyte growth factor	Homo sapiens	61-65
32032576-5	2020	In this study, we investigated whether quercetin affects the HGF- or TGF-alpha induced migration of HuH7 cells.	Quercetin	39-48	transforming growth factor alpha	Homo sapiens	69-78
32032576-6	2020	Quercetin significantly suppressed both HGF- and TGF-alpha-induced migration of HuH7 cells in a dose-dependent manner.	Quercetin	0-9	hepatocyte growth factor	Homo sapiens	40-43
32032576-6	2020	Quercetin significantly suppressed both HGF- and TGF-alpha-induced migration of HuH7 cells in a dose-dependent manner.	Quercetin	0-9	transforming growth factor alpha	Homo sapiens	49-58
32032576-10	2020	On the contrary, quercetin and myricetin inhibited the growth factors-induced phosphorylation of AKT.	Quercetin	17-26	AKT serine/threonine kinase 1	Homo sapiens	97-100
32032576-11	2020	Our results strongly suggest that quercetin suppresses the growth factor-induced migration of HCC cells by inhibiting the signaling pathway of AKT but not p38 MAPK.	Quercetin	34-43	AKT serine/threonine kinase 1	Homo sapiens	143-146
31897859-4	2020	TNF-alpha and IL-8 mRNA expressions significantly decreased as the levels of quercetin increased up to 1 mug/L and increased thereafter (P < 0.05).	Quercetin	77-86	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	0-9
31897859-4	2020	TNF-alpha and IL-8 mRNA expressions significantly decreased as the levels of quercetin increased up to 1 mug/L and increased thereafter (P < 0.05).	Quercetin	77-86	chemokine (C-X-C motif) ligand 8a	Danio rerio	14-18
31897859-5	2020	1 and 10 mug/L quercetin groups showed significantly lower TNF-alpha and IL-8 mRNA levels than the quercetin-free group.	Quercetin	15-24	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	59-68
31897859-5	2020	1 and 10 mug/L quercetin groups showed significantly lower TNF-alpha and IL-8 mRNA levels than the quercetin-free group.	Quercetin	15-24	chemokine (C-X-C motif) ligand 8a	Danio rerio	73-77
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-86
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	87-90
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	91-95
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	jun proto-oncogene	Mus musculus	98-102
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	jun proto-oncogene	Mus musculus	103-108
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	prostaglandin-endoperoxide synthase 2	Mus musculus	115-131
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	prostaglandin-endoperoxide synthase 2	Mus musculus	132-137
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	interleukin 6	Mus musculus	144-157
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	interleukin 6	Mus musculus	158-161
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	230-233
32157554-9	2020	Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level.	Quercetin	14-23	jun proto-oncogene	Mus musculus	238-243
32157554-10	2020	Based on these observations, we concluded that quercetin exerts inhibitory effect on LPS-induced experimental mice preterm labor and increases offspring survival through a mechanism involving NF-kappaB/AP-1 pathway.	Quercetin	47-56	jun proto-oncogene	Mus musculus	202-206
32489059-7	2020	Molecular docking prediction showed that luteolin, quercetin and catalpol had a strong binding activity with Akt1; luteolin had strong binding activity but quercetin and catalpol had a certain binding activity with TNFalpha.	Quercetin	51-60	AKT serine/threonine kinase 1	Homo sapiens	109-113
32489059-7	2020	Molecular docking prediction showed that luteolin, quercetin and catalpol had a strong binding activity with Akt1; luteolin had strong binding activity but quercetin and catalpol had a certain binding activity with TNFalpha.	Quercetin	51-60	tumor necrosis factor	Homo sapiens	215-223
32225128-0	2020	Quercetin Inhibits the Proliferation and Metastasis of Human Non-Small Cell Lung Cancer Cell Line: The Key Role of Src-Mediated Fibroblast Growth Factor-Inducible 14 (Fn14)/ Nuclear Factor kappa B (NF-kappaB) pathway.	Quercetin	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-118
32225128-0	2020	Quercetin Inhibits the Proliferation and Metastasis of Human Non-Small Cell Lung Cancer Cell Line: The Key Role of Src-Mediated Fibroblast Growth Factor-Inducible 14 (Fn14)/ Nuclear Factor kappa B (NF-kappaB) pathway.	Quercetin	0-9	TNF receptor superfamily member 12A	Homo sapiens	167-171
32225128-0	2020	Quercetin Inhibits the Proliferation and Metastasis of Human Non-Small Cell Lung Cancer Cell Line: The Key Role of Src-Mediated Fibroblast Growth Factor-Inducible 14 (Fn14)/ Nuclear Factor kappa B (NF-kappaB) pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	174-196
32225128-0	2020	Quercetin Inhibits the Proliferation and Metastasis of Human Non-Small Cell Lung Cancer Cell Line: The Key Role of Src-Mediated Fibroblast Growth Factor-Inducible 14 (Fn14)/ Nuclear Factor kappa B (NF-kappaB) pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	198-207
32225128-3	2020	In the current study, the interaction between Que and Src signaling in NSCLC cells was explored to explain the anti-NSCLC function of Que.	Quercetin	46-49	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	54-57
32214800-10	2020	Especially, 12 out of 16 key active ingredients, including validated quercetin, were well docked to IL-6 proteins.	Quercetin	69-78	interleukin 6	Rattus norvegicus	100-104
31836515-10	2020	Among the main phenolic compounds of EETg, quercitrin, quercetin and catechin showed the highest binding affinity in silico to MPO.	Quercetin	55-64	myeloperoxidase	Homo sapiens	127-130
31982469-0	2020	Quercetin Reduces Ischemic Brain Injury by Preventing Ischemia-induced Decreases in the Neuronal Calcium Sensor Protein Hippocalcin.	Quercetin	0-9	hippocalcin	Rattus norvegicus	120-131
31964531-0	2020	Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway.	Quercetin	0-9	notch receptor 1	Homo sapiens	88-95
31964531-3	2020	In this study, we demonstrated that quercetin-IR combination treatment exhibited more dramatic anti-cancer effect than either quercetin or IR treatment alone via targeting colon cancer stem cells (CSCs) and inhibiting the Notch-1 signaling.	Quercetin	36-45	notch receptor 1	Homo sapiens	222-229
31964531-7	2020	In conclusion, our results indicated that the combination of quercetin (20 muM) and IR (5Gy) might be a promising therapeutic strategy for colon cancer treatment by targeting colon cancer stem-like cells and inhibiting the Notch-1 signaling.	Quercetin	61-70	notch receptor 1	Homo sapiens	223-230
31982469-5	2020	We studied modulation of hippocalcin expression by quercetin treatment in cerebral ischemic injury and glutamate-induced neuronal cell damage.	Quercetin	51-60	hippocalcin	Rattus norvegicus	25-36
32210615-0	2020	Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1.	Quercetin	0-9	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	138-144
31982469-15	2020	Quercetin treatment attenuated the increase of caspase-3.	Quercetin	0-9	caspase 3	Rattus norvegicus	47-56
31982469-16	2020	Taken together, these results suggest that quercetin exerts a preventative effect through attenuation of intracellular calcium overload and restoration of down-regulated hippocalcin expression during ischemic injury.	Quercetin	43-52	hippocalcin	Rattus norvegicus	170-181
32160160-0	2020	Quercetin modulates granulosa cell mRNA androgen receptor gene expression in dehydroepiandrosterone-induced polycystic ovary in Wistar rats via metabolic and hormonal pathways.	Quercetin	0-9	androgen receptor	Rattus norvegicus	40-57
32164219-1	2020	The purpose of this study was to evaluate the effect of chronic quercetin treatment on mitochondrial biogenesis, endurance exercise performance and activation levels of AMP-activated protein kinase (AMPK) in rat skeletal muscle.	Quercetin	64-73	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	169-197
32164219-1	2020	The purpose of this study was to evaluate the effect of chronic quercetin treatment on mitochondrial biogenesis, endurance exercise performance and activation levels of AMP-activated protein kinase (AMPK) in rat skeletal muscle.	Quercetin	64-73	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	199-203
32164219-6	2020	On the other hand, the AMPK phosphorylation level immediately after exercise was significantly lower in quercetin-treated muscles, suggesting that quercetin treatment might provide a disadvantage to muscle adaptation when administered with exercise training.	Quercetin	104-113	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	23-27
32164219-6	2020	On the other hand, the AMPK phosphorylation level immediately after exercise was significantly lower in quercetin-treated muscles, suggesting that quercetin treatment might provide a disadvantage to muscle adaptation when administered with exercise training.	Quercetin	147-156	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	23-27
32210615-6	2020	Previous data showed that quercetin promoted the apoptosis of fibroblast-like synoviocytes by upregulating MALAT1 in rheumatoid arthritis.	Quercetin	26-35	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	107-113
32210615-9	2020	A series of in vitro and in vivo functional experiments were carried out to elucidate the role of MALAT1 in quercetin treatment against PC.	Quercetin	108-117	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	98-104
32210615-11	2020	Results: We showed for the first time that MALAT1 expression was significantly downregulated in quercetin-treated PC cells in a dose- and time-dependent manner.	Quercetin	96-105	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	43-49
32210615-13	2020	Moreover, quercetin suppressed EMT process, promoted apoptosis and deactivated PI3K/Akt signaling pathway during the progression of PC.	Quercetin	10-19	AKT serine/threonine kinase 1	Homo sapiens	84-87
32210615-14	2020	MALAT1 overexpression in PC cells resulted in the resistance against quercetin treatment.	Quercetin	69-78	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-6
32210615-15	2020	Conclusion: Our study illustrated, for the first time, that MALAT1 played an important role in quercetin treatment against PC by inhibiting EMT process and promoting apoptosis, providing a new molecular basis for the application of quercetin in PC treatment.	Quercetin	95-104	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-66
32210615-15	2020	Conclusion: Our study illustrated, for the first time, that MALAT1 played an important role in quercetin treatment against PC by inhibiting EMT process and promoting apoptosis, providing a new molecular basis for the application of quercetin in PC treatment.	Quercetin	232-241	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	60-66
31545905-7	2020	In MCF-7 cells, the following changes were observed: an increase of omega6 linoleic acid in the cells incubated with somatostatin + quercetin and quercetin and a decrease of omega3 acids in the cells incubated with somatostatin + curcumin compared to somatostatin and significant increases of monounsaturated fatty acid (MUFA), mono-trans arachidonic acid levels and docosapentaenoic acid for the cells incubated with somatostatin + quercetin compared to the control cells.	Quercetin	132-141	somatostatin	Homo sapiens	117-129
31545905-8	2020	In MDA-MB231 cells, incubations with curcumin, quercetin, and somatostatin + quercetin induced the most significant membrane remodeling with the increase of stearic acid, diminution of omega6 linoleic, arachidonic acids, and omega3 (docosapentaenoic and docosahexaenoic acids).	Quercetin	77-86	somatostatin	Homo sapiens	62-74
30706126-7	2020	The rescue of survival due to quercetin in glucose-exposed nematodes was completely prevented under RNAi versus ubql-1 or dnc-1.	Quercetin	30-39	Ubiquilin	Caenorhabditis elegans	112-118
31545905-10	2020	In MCF-7 cells, separate or combined incubations with somatostatin and quercetin, significantly decreased EGFR and incubation with curcumin decreased MAPK signaling.	Quercetin	71-80	epidermal growth factor receptor	Homo sapiens	106-110
31545905-12	2020	Incubation with curcumin and quercetin decreased the EGFR levels.	Quercetin	29-38	epidermal growth factor receptor	Homo sapiens	53-57
30706126-7	2020	The rescue of survival due to quercetin in glucose-exposed nematodes was completely prevented under RNAi versus ubql-1 or dnc-1.	Quercetin	30-39	Dynactin domain-containing protein;Dynactin subunit 1	Caenorhabditis elegans	122-127
31894470-0	2020	Revealing the Mechanism of EGCG, Genistein, Rutin, Quercetin, and Silibinin Against hIAPP Aggregation via Computational Simulations.	Quercetin	51-60	islet amyloid polypeptide	Homo sapiens	84-89
30706126-9	2020	Finally, the knockdown of ubql-1 and dnc-1 blocked the increase of proteasomal activity achieved by quercetin in glucose-treated nematodes.	Quercetin	100-109	Ubiquilin	Caenorhabditis elegans	26-32
30706126-9	2020	Finally, the knockdown of ubql-1 and dnc-1 blocked the increase of proteasomal activity achieved by quercetin in glucose-treated nematodes.	Quercetin	100-109	Dynactin domain-containing protein;Dynactin subunit 1	Caenorhabditis elegans	37-42
31894470-5	2020	We show that these flavonoids can disaggregate Chain A and Chain B of hIAPP to reduce the extended conformation by binding with two regions of hIAPP, Leu12-Ala13-Asn14 and Asn31-Val32-Gly33-Ser34-Asn35, with the inhibitory ability of Genistein > Rutin > Quercetin > EGCG > Silibinin.	Quercetin	254-263	islet amyloid polypeptide	Homo sapiens	70-75
32053272-0	2020	Quercetin inhibits macrophage polarization through the p-38alpha/beta signalling pathway and regulates OPG/RANKL balance in a mouse skull model.	Quercetin	0-9	mitogen-activated protein kinase 14	Mus musculus	55-64
30963942-9	2020	An experimental validation was carried out against the activated forms of Fyn, Lyn and Src kinases, the top three proteins which showed high preference for quercetin.	Quercetin	156-165	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	87-90
32000299-0	2020	Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice.	Quercetin	0-9	sirtuin 1	Mus musculus	55-60
32000299-0	2020	Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	61-66
32000299-4	2020	In this study, we used the db/db mice (diabetic model) to discover whether quercetin could improve DE through the Sirtuin1/NLRP3 (NOD-, LRR- and pyrin domain-containing 3) pathway.	Quercetin	75-84	sirtuin 1	Mus musculus	114-122
30963942-6	2020	To get a deeper insight into the binding of quercetin with the SFK, a combined molecular dynamics and binding free energy calculations were performed.	Quercetin	44-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	63-66
30963942-7	2020	The binding of quercetin disrupted the intra-molecular contacts making the SFK compact except Src kinase.	Quercetin	15-24	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	75-78
30963942-7	2020	The binding of quercetin disrupted the intra-molecular contacts making the SFK compact except Src kinase.	Quercetin	15-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	94-97
30963942-9	2020	An experimental validation was carried out against the activated forms of Fyn, Lyn and Src kinases, the top three proteins which showed high preference for quercetin.	Quercetin	156-165	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
30963942-9	2020	An experimental validation was carried out against the activated forms of Fyn, Lyn and Src kinases, the top three proteins which showed high preference for quercetin.	Quercetin	156-165	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
32000299-4	2020	In this study, we used the db/db mice (diabetic model) to discover whether quercetin could improve DE through the Sirtuin1/NLRP3 (NOD-, LRR- and pyrin domain-containing 3) pathway.	Quercetin	75-84	NLR family, pyrin domain containing 3	Mus musculus	123-128
32053272-0	2020	Quercetin inhibits macrophage polarization through the p-38alpha/beta signalling pathway and regulates OPG/RANKL balance in a mouse skull model.	Quercetin	0-9	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	103-106
32000299-7	2020	Besides, Western blot analysis also showed that quercetin increased the protein expressions of nerve- and synapse-related protein, including postsynapticdensity 93 (PSD93), postsynapticdensity 95 (PSD95), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the brain of db/db mice.	Quercetin	48-57	brain derived neurotrophic factor	Mus musculus	205-238
32000299-7	2020	Besides, Western blot analysis also showed that quercetin increased the protein expressions of nerve- and synapse-related protein, including postsynapticdensity 93 (PSD93), postsynapticdensity 95 (PSD95), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the brain of db/db mice.	Quercetin	48-57	brain derived neurotrophic factor	Mus musculus	240-244
32000299-8	2020	Quercetin also increased the protein expression of SIRT1 and decreased the expression of NLRP3 inflammation-related proteins, including NLRP3, the adaptor protein ASC and cleaved Caspase-1, the pro-inflammatory cytokines IL-1beta and IL-18.	Quercetin	0-9	sirtuin 1	Mus musculus	51-56
32000299-8	2020	Quercetin also increased the protein expression of SIRT1 and decreased the expression of NLRP3 inflammation-related proteins, including NLRP3, the adaptor protein ASC and cleaved Caspase-1, the pro-inflammatory cytokines IL-1beta and IL-18.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	89-94
32000299-8	2020	Quercetin also increased the protein expression of SIRT1 and decreased the expression of NLRP3 inflammation-related proteins, including NLRP3, the adaptor protein ASC and cleaved Caspase-1, the pro-inflammatory cytokines IL-1beta and IL-18.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	136-141
32000299-8	2020	Quercetin also increased the protein expression of SIRT1 and decreased the expression of NLRP3 inflammation-related proteins, including NLRP3, the adaptor protein ASC and cleaved Caspase-1, the pro-inflammatory cytokines IL-1beta and IL-18.	Quercetin	0-9	PYD and CARD domain containing	Mus musculus	163-166
32000299-8	2020	Quercetin also increased the protein expression of SIRT1 and decreased the expression of NLRP3 inflammation-related proteins, including NLRP3, the adaptor protein ASC and cleaved Caspase-1, the pro-inflammatory cytokines IL-1beta and IL-18.	Quercetin	0-9	interleukin 1 alpha	Mus musculus	221-229
32053272-0	2020	Quercetin inhibits macrophage polarization through the p-38alpha/beta signalling pathway and regulates OPG/RANKL balance in a mouse skull model.	Quercetin	0-9	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	107-112
32000299-8	2020	Quercetin also increased the protein expression of SIRT1 and decreased the expression of NLRP3 inflammation-related proteins, including NLRP3, the adaptor protein ASC and cleaved Caspase-1, the pro-inflammatory cytokines IL-1beta and IL-18.	Quercetin	0-9	interleukin 18	Mus musculus	234-239
32110995-0	2020	Quercetin Protects Against Lipopolysaccharide-Induced Intestinal Oxidative Stress in Broiler Chickens through Activation of Nrf2 Pathway.	Quercetin	0-9	nuclear factor, erythroid 2 like 2	Gallus gallus	124-128
32000299-9	2020	In conclusion, the present results indicate that the SIRT1/NLRP3 pathway may be a crucial mechanism for the neuroprotective effect of quercetin against DE.	Quercetin	134-143	sirtuin 1	Mus musculus	53-58
32000299-9	2020	In conclusion, the present results indicate that the SIRT1/NLRP3 pathway may be a crucial mechanism for the neuroprotective effect of quercetin against DE.	Quercetin	134-143	NLR family, pyrin domain containing 3	Mus musculus	59-64
32121354-5	2020	The protective effect of quercetin and its mixture may be attributed to its down-regulation of HUS-1, CEP-1, EGL-1 and CED-13.	Quercetin	25-34	Checkpoint protein	Caenorhabditis elegans	95-100
32121354-5	2020	The protective effect of quercetin and its mixture may be attributed to its down-regulation of HUS-1, CEP-1, EGL-1 and CED-13.	Quercetin	25-34	Transcription factor cep-1	Caenorhabditis elegans	102-107
32121354-5	2020	The protective effect of quercetin and its mixture may be attributed to its down-regulation of HUS-1, CEP-1, EGL-1 and CED-13.	Quercetin	25-34	Programmed cell death activator egl-1	Caenorhabditis elegans	109-114
32121354-5	2020	The protective effect of quercetin and its mixture may be attributed to its down-regulation of HUS-1, CEP-1, EGL-1 and CED-13.	Quercetin	25-34	Uncharacterized protein	Caenorhabditis elegans	119-125
31982837-16	2020	Quercetin having anti-cancer activity induce the apoptosis through regulating miR-16, 26b, 34a, let-7g, 125a and miR-605 and reduce the miRNA expression like miR-146a/b, 503 and 194 which are involved in metastasis.	Quercetin	0-9	glycerophosphodiester phosphodiesterase 1	Homo sapiens	78-84
31982837-16	2020	Quercetin having anti-cancer activity induce the apoptosis through regulating miR-16, 26b, 34a, let-7g, 125a and miR-605 and reduce the miRNA expression like miR-146a/b, 503 and 194 which are involved in metastasis.	Quercetin	0-9	microRNA let-7g	Homo sapiens	96-102
31982837-16	2020	Quercetin having anti-cancer activity induce the apoptosis through regulating miR-16, 26b, 34a, let-7g, 125a and miR-605 and reduce the miRNA expression like miR-146a/b, 503 and 194 which are involved in metastasis.	Quercetin	0-9	microRNA 605	Homo sapiens	113-120
31982837-16	2020	Quercetin having anti-cancer activity induce the apoptosis through regulating miR-16, 26b, 34a, let-7g, 125a and miR-605 and reduce the miRNA expression like miR-146a/b, 503 and 194 which are involved in metastasis.	Quercetin	0-9	microRNA 146a	Homo sapiens	158-168
31967793-0	2020	Correction to Quercetin-Modified Metal-Organic Frameworks for Dual Sensitization of Radiotherapy in Tumor Tissues by Inhibiting the Carbonic Anhydrase IX.	Quercetin	14-23	carbonic anhydrase 9	Homo sapiens	132-153
32110995-4	2020	Quercetin significantly inhibited LPS-induced jejunal oxidative stress, including downregulated reactive oxygen species (ROS), malondialdehyde (MDA), and 8-hydroxy-2"-deoxyguanosine (8-OHdG) levels, and it upregulated superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels.	Quercetin	0-9	superoxide dismutase 2, mitochondrial	Gallus gallus	240-243
32110995-5	2020	Quercetin relieved LPS-induced jejunal mitochondria damage and upregulated mitochondrial DNA copy number-related gene expression, including cytochrome c oxidase subunit 1 (COX1), ATP synthase F0 subunit 6 (ATP6), and NADH dehydrogenase subunit 1 (ND1).	Quercetin	0-9	COX1	Gallus gallus	172-176
32110995-5	2020	Quercetin relieved LPS-induced jejunal mitochondria damage and upregulated mitochondrial DNA copy number-related gene expression, including cytochrome c oxidase subunit 1 (COX1), ATP synthase F0 subunit 6 (ATP6), and NADH dehydrogenase subunit 1 (ND1).	Quercetin	0-9	ATP6	Gallus gallus	179-204
32110995-5	2020	Quercetin relieved LPS-induced jejunal mitochondria damage and upregulated mitochondrial DNA copy number-related gene expression, including cytochrome c oxidase subunit 1 (COX1), ATP synthase F0 subunit 6 (ATP6), and NADH dehydrogenase subunit 1 (ND1).	Quercetin	0-9	ATP6	Gallus gallus	206-210
32110995-5	2020	Quercetin relieved LPS-induced jejunal mitochondria damage and upregulated mitochondrial DNA copy number-related gene expression, including cytochrome c oxidase subunit 1 (COX1), ATP synthase F0 subunit 6 (ATP6), and NADH dehydrogenase subunit 1 (ND1).	Quercetin	0-9	ND1	Gallus gallus	217-245
32110995-5	2020	Quercetin relieved LPS-induced jejunal mitochondria damage and upregulated mitochondrial DNA copy number-related gene expression, including cytochrome c oxidase subunit 1 (COX1), ATP synthase F0 subunit 6 (ATP6), and NADH dehydrogenase subunit 1 (ND1).	Quercetin	0-9	ND1	Gallus gallus	247-250
32110995-6	2020	Quercetin attenuated the LPS-induced inhibition of Nrf2 activation, translocation, and downstream gene expression, including heme oxygenase-1 (HO-1), NAD (P) H dehydrogenase quinone 1 (NQO1), and manganese superoxide dismutase (SOD2).	Quercetin	0-9	nuclear factor, erythroid 2 like 2	Gallus gallus	51-55
32110995-6	2020	Quercetin attenuated the LPS-induced inhibition of Nrf2 activation, translocation, and downstream gene expression, including heme oxygenase-1 (HO-1), NAD (P) H dehydrogenase quinone 1 (NQO1), and manganese superoxide dismutase (SOD2).	Quercetin	0-9	heme oxygenase 1	Gallus gallus	125-141
32110995-6	2020	Quercetin attenuated the LPS-induced inhibition of Nrf2 activation, translocation, and downstream gene expression, including heme oxygenase-1 (HO-1), NAD (P) H dehydrogenase quinone 1 (NQO1), and manganese superoxide dismutase (SOD2).	Quercetin	0-9	NAD(P)H quinone dehydrogenase 1	Gallus gallus	150-183
32110995-6	2020	Quercetin attenuated the LPS-induced inhibition of Nrf2 activation, translocation, and downstream gene expression, including heme oxygenase-1 (HO-1), NAD (P) H dehydrogenase quinone 1 (NQO1), and manganese superoxide dismutase (SOD2).	Quercetin	0-9	NAD(P)H quinone dehydrogenase 1	Gallus gallus	185-189
32110995-6	2020	Quercetin attenuated the LPS-induced inhibition of Nrf2 activation, translocation, and downstream gene expression, including heme oxygenase-1 (HO-1), NAD (P) H dehydrogenase quinone 1 (NQO1), and manganese superoxide dismutase (SOD2).	Quercetin	0-9	superoxide dismutase 2, mitochondrial	Gallus gallus	228-232
32110995-7	2020	Additionally, quercetin attenuated the LPS-inhibition of c-Jun N-terminal kinase (JNK), Extracellular Regulated protein Kinases (ERK), and p38MAPK (p38) phosphorylation in the MAPK pathway.	Quercetin	14-23	adapter molecule crk	Gallus gallus	139-146
32110995-7	2020	Additionally, quercetin attenuated the LPS-inhibition of c-Jun N-terminal kinase (JNK), Extracellular Regulated protein Kinases (ERK), and p38MAPK (p38) phosphorylation in the MAPK pathway.	Quercetin	14-23	adapter molecule crk	Gallus gallus	139-142
32110995-8	2020	Thus, quercetin attenuated LPS-induced oxidative stress in the intestines of broiler chickens via the MAPK/Nrf2 signaling pathway.	Quercetin	6-15	nuclear factor, erythroid 2 like 2	Gallus gallus	107-111
31669938-8	2020	Immunofluorescence results showed that treatment with quercetin (Qc), catechin (Cat) and capsaicin (Cap) induced the translocation of Nrf2 into the nucleus, at the same level as did H2O2 treatment, thus mimicking the action of the endogenous cell response to peroxidation.	Quercetin	54-63	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
32085461-7	2020	We also evaluated, by using Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR), the expression of Higd2a gene in healthy bone marrow-liver-spleen tissues of mice after quercetin (50 mg/kg) treatment.	Quercetin	198-207	HIG1 domain family, member 2A	Mus musculus	128-134
32085461-13	2020	In addition, it was observed that quercetin modulated the expression of Higd2a gene in mice.	Quercetin	34-43	HIG1 domain family, member 2A	Mus musculus	72-78
31669938-8	2020	Immunofluorescence results showed that treatment with quercetin (Qc), catechin (Cat) and capsaicin (Cap) induced the translocation of Nrf2 into the nucleus, at the same level as did H2O2 treatment, thus mimicking the action of the endogenous cell response to peroxidation.	Quercetin	65-67	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
31144159-9	2020	After quercetin intervention, the areas of AS plaques and the expressions of PCSK9, TNF-alpha and IL-6 were significantly reduced (all P&lt;0.01), while the expressions of ABCA1 and LXR-alpha were increased significantly (all P&lt;0.01).	Quercetin	6-15	proprotein convertase subtilisin/kexin type 9	Mus musculus	77-82
32174789-0	2020	Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways.	Quercetin	0-9	androgen receptor	Homo sapiens	63-80
32174789-0	2020	Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	90-93
31870832-0	2020	Quercetin protects the vascular endothelium against iron overload damages via ROS/ADMA/DDAHII/eNOS/NO pathway.	Quercetin	0-9	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	87-93
31870832-3	2020	Therefore, we aimed to explore the protective mechanism of Que on iron overload induced HUVECs injury focused on ROS/ADMA/DDAHII/eNOS/NO pathway.	Quercetin	59-62	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	122-128
31870832-5	2020	After addition of pAD/DDAHII-shRNA, the effects of Que mentioned above were reversed.	Quercetin	51-54	peptidyl arginine deiminase 4	Homo sapiens	18-21
31870832-5	2020	After addition of pAD/DDAHII-shRNA, the effects of Que mentioned above were reversed.	Quercetin	51-54	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	22-28
31870832-9	2020	These results illustrated that Que could attenuate iron overload induced HUVECs mitochondrial dysfunction via ROS/ADMA/DDAHII/eNOS/NO pathway.	Quercetin	31-34	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	119-125
32059743-10	2020	With nanoliposomal quercetin treatment, the serum levels of GPT, GOT and DBIL were significantly better than treated with pure quercetin.	Quercetin	19-28	glutamic--pyruvic transaminase	Rattus norvegicus	60-63
32050534-3	2020	To investigate whether quercetin also inhibits transforming growth factor beta1 (TGF-beta1)-induced epithelial-mesenchymal transition (EMT) in human keratinocyte cells, HaCaT cells were treated with TGF-beta1.	Quercetin	23-32	transforming growth factor beta 1	Homo sapiens	47-79
32050534-3	2020	To investigate whether quercetin also inhibits transforming growth factor beta1 (TGF-beta1)-induced epithelial-mesenchymal transition (EMT) in human keratinocyte cells, HaCaT cells were treated with TGF-beta1.	Quercetin	23-32	transforming growth factor beta 1	Homo sapiens	81-90
32050534-6	2020	Additionally, quercetin suppresses cell migration through EMT and matrix metalloproteinase (MMP) in OSCC cells and decreases TGF-beta1-induced EMT in HaCaT cells.	Quercetin	14-23	transforming growth factor beta 1	Homo sapiens	125-134
31144159-0	2020	Effect of Quercetin on Atherosclerosis Based on Expressions of ABCA1, LXR-alpha and PCSK9 in ApoE-/- Mice.	Quercetin	10-19	nuclear receptor subfamily 1, group H, member 3	Mus musculus	70-79
31144159-0	2020	Effect of Quercetin on Atherosclerosis Based on Expressions of ABCA1, LXR-alpha and PCSK9 in ApoE-/- Mice.	Quercetin	10-19	proprotein convertase subtilisin/kexin type 9	Mus musculus	84-89
31144159-1	2020	OBJECTIVE: To investigate the effect of quercetin on ATP binding cassette transporter A1 (ABCA1), liver X receptor (LXR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) expressions in apoE-knockout (ApoE-/-) mice.	Quercetin	40-49	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	53-88
31144159-1	2020	OBJECTIVE: To investigate the effect of quercetin on ATP binding cassette transporter A1 (ABCA1), liver X receptor (LXR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) expressions in apoE-knockout (ApoE-/-) mice.	Quercetin	40-49	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	90-95
31144159-9	2020	After quercetin intervention, the areas of AS plaques and the expressions of PCSK9, TNF-alpha and IL-6 were significantly reduced (all P&lt;0.01), while the expressions of ABCA1 and LXR-alpha were increased significantly (all P&lt;0.01).	Quercetin	6-15	tumor necrosis factor	Mus musculus	84-93
31144159-9	2020	After quercetin intervention, the areas of AS plaques and the expressions of PCSK9, TNF-alpha and IL-6 were significantly reduced (all P&lt;0.01), while the expressions of ABCA1 and LXR-alpha were increased significantly (all P&lt;0.01).	Quercetin	6-15	interleukin 6	Mus musculus	98-102
31144159-9	2020	After quercetin intervention, the areas of AS plaques and the expressions of PCSK9, TNF-alpha and IL-6 were significantly reduced (all P&lt;0.01), while the expressions of ABCA1 and LXR-alpha were increased significantly (all P&lt;0.01).	Quercetin	6-15	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	172-177
31144159-9	2020	After quercetin intervention, the areas of AS plaques and the expressions of PCSK9, TNF-alpha and IL-6 were significantly reduced (all P&lt;0.01), while the expressions of ABCA1 and LXR-alpha were increased significantly (all P&lt;0.01).	Quercetin	6-15	nuclear receptor subfamily 1, group H, member 3	Mus musculus	182-191
31144159-10	2020	CONCLUSION: Quercetin effectively interfered with AS development by regulating the expressions of ABCA1, LXR- alpha and PCSK9 in ApoE-/- mice.	Quercetin	12-21	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	98-103
31144159-10	2020	CONCLUSION: Quercetin effectively interfered with AS development by regulating the expressions of ABCA1, LXR- alpha and PCSK9 in ApoE-/- mice.	Quercetin	12-21	nuclear receptor subfamily 1, group H, member 3	Mus musculus	105-115
31144159-10	2020	CONCLUSION: Quercetin effectively interfered with AS development by regulating the expressions of ABCA1, LXR- alpha and PCSK9 in ApoE-/- mice.	Quercetin	12-21	proprotein convertase subtilisin/kexin type 9	Mus musculus	120-125
31144159-10	2020	CONCLUSION: Quercetin effectively interfered with AS development by regulating the expressions of ABCA1, LXR- alpha and PCSK9 in ApoE-/- mice.	Quercetin	12-21	apolipoprotein E	Mus musculus	129-133
32957814-5	2020	Quercetin treatment increased the expressions of IL-10, VEGF, TGF-beta1, CD31, alpha-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-alpha.	Quercetin	0-9	interleukin 10	Rattus norvegicus	49-54
32957814-5	2020	Quercetin treatment increased the expressions of IL-10, VEGF, TGF-beta1, CD31, alpha-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-alpha.	Quercetin	0-9	vascular endothelial growth factor A	Rattus norvegicus	56-60
32957814-5	2020	Quercetin treatment increased the expressions of IL-10, VEGF, TGF-beta1, CD31, alpha-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-alpha.	Quercetin	0-9	transforming growth factor, beta 1	Rattus norvegicus	62-71
32957814-5	2020	Quercetin treatment increased the expressions of IL-10, VEGF, TGF-beta1, CD31, alpha-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-alpha.	Quercetin	0-9	platelet and endothelial cell adhesion molecule 1	Rattus norvegicus	73-77
32957814-5	2020	Quercetin treatment increased the expressions of IL-10, VEGF, TGF-beta1, CD31, alpha-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-alpha.	Quercetin	0-9	proliferating cell nuclear antigen	Rattus norvegicus	90-94
32957814-5	2020	Quercetin treatment increased the expressions of IL-10, VEGF, TGF-beta1, CD31, alpha-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-alpha.	Quercetin	0-9	growth associated protein 43	Rattus norvegicus	100-106
32957814-5	2020	Quercetin treatment increased the expressions of IL-10, VEGF, TGF-beta1, CD31, alpha-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-alpha.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	141-150
31192773-4	2020	Our hypotheses were that exposure of cancer and kidney cells to genistein, kaempferol, and quercetin can increase PTEN and decrease lipid peroxides in PBMCs levels respectively to better cope with oxidative stress.	Quercetin	91-100	phosphatase and tensin homolog	Homo sapiens	114-118
31606511-9	2020	Immunohistochemistry tests showed more CD206-positive cells and less iNOS-positive cells in quercetin-treated groups.	Quercetin	92-101	inositol-3-phosphate synthase 1	Homo sapiens	69-73
31832781-0	2020	Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity.	Quercetin	57-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32
31832781-1	2020	In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2"-bipyiridine) ligands.	Quercetin	88-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
31876980-0	2020	Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase.	Quercetin	0-9	catalase	Rattus norvegicus	245-253
31876980-0	2020	Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase.	Quercetin	215-224	catalase	Rattus norvegicus	245-253
31876980-3	2020	The altered activities of glucose-6-phosphatase and hexokinase in diabetic rats were significantly improved upon quercetin treatment.	Quercetin	113-122	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	26-47
31876980-7	2020	Molecular docking of quercetin showed a high affinity for hexokinase and CAT with a binding energy of -7.82 and -9.83 kcal/mol, respectively, more elevated than the standard drugs.	Quercetin	21-30	catalase	Rattus norvegicus	73-76
31773385-6	2020	Quercetin and caffeic acid in old fibroblast cells showed higher clock gene expression than resveratrol, quercetin increased Sirt1 expression, and caffeic acid increased Sirt6 expression indicating the possibility of an anti-aging effect.	Quercetin	0-9	sirtuin 6	Homo sapiens	170-175
31863770-5	2020	LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid.	Quercetin	8-11	microRNA 339	Mus musculus	147-154
31863770-5	2020	LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid.	Quercetin	8-11	microRNA 383	Mus musculus	156-163
31863770-5	2020	LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid.	Quercetin	8-11	microRNA 146b	Mus musculus	168-176
31863770-5	2020	LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid.	Quercetin	8-11	microRNA 200a	Mus musculus	219-227
31863770-5	2020	LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid.	Quercetin	8-11	nuclear factor, erythroid derived 2, like 2	Mus musculus	228-232
31863770-8	2020	SIGNIFICANCE: Our data indicated that amelioration of hepatic steatosis by LF, CR, Que and Ex resulted in many shared, but also many differential changes in the miR-dependent TH production and action.	Quercetin	83-86	microRNA 297b	Mus musculus	161-164
31773385-6	2020	Quercetin and caffeic acid in old fibroblast cells showed higher clock gene expression than resveratrol, quercetin increased Sirt1 expression, and caffeic acid increased Sirt6 expression indicating the possibility of an anti-aging effect.	Quercetin	105-114	sirtuin 1	Homo sapiens	125-130
31773385-7	2020	Also, quercetin and caffeic acid showed higher clock-controlled gene (Sirt1 and NR1D1) expression than resveratrol in young fibroblast cells.	Quercetin	6-15	sirtuin 1	Homo sapiens	70-75
31773385-7	2020	Also, quercetin and caffeic acid showed higher clock-controlled gene (Sirt1 and NR1D1) expression than resveratrol in young fibroblast cells.	Quercetin	6-15	nuclear receptor subfamily 1 group D member 1	Homo sapiens	80-85
32524112-15	2020	CONCLUSIONS: Rapid maxillary expansion can enlarge the middle palatal suture of rats during growth and development, quercetin can promote the expression of BMP-2 in the middle palatal suture of rats during rapid maxillary expansion, make bone deposition and calcification, and accelerate new bone formation.	Quercetin	116-125	bone morphogenetic protein 2	Rattus norvegicus	156-161
31860939-5	2020	This may be since quercetin 1) increased miR-219, miR-15a, and miR-132 expression, inhibited p-ERK1/2, and tau phosphorylation; and 2) improved gut microbiota richness and diversity, inhibited phylum Tenericutes and Proteobacteria, and elevated butyric acid from cecum.	Quercetin	18-27	microRNA 15a	Mus musculus	50-57
31860939-5	2020	This may be since quercetin 1) increased miR-219, miR-15a, and miR-132 expression, inhibited p-ERK1/2, and tau phosphorylation; and 2) improved gut microbiota richness and diversity, inhibited phylum Tenericutes and Proteobacteria, and elevated butyric acid from cecum.	Quercetin	18-27	microRNA 132	Mus musculus	63-70
31860939-5	2020	This may be since quercetin 1) increased miR-219, miR-15a, and miR-132 expression, inhibited p-ERK1/2, and tau phosphorylation; and 2) improved gut microbiota richness and diversity, inhibited phylum Tenericutes and Proteobacteria, and elevated butyric acid from cecum.	Quercetin	18-27	mitogen-activated protein kinase 3	Mus musculus	95-101
31661670-8	2020	Treatment with quercetin increased the adiponectin level and expression of adipoR1 and nesfatin-1 and decreased both the expression of aromatase and the oestradiol level.	Quercetin	15-24	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	39-50
31661670-8	2020	Treatment with quercetin increased the adiponectin level and expression of adipoR1 and nesfatin-1 and decreased both the expression of aromatase and the oestradiol level.	Quercetin	15-24	adiponectin receptor 1	Rattus norvegicus	75-82
31661670-8	2020	Treatment with quercetin increased the adiponectin level and expression of adipoR1 and nesfatin-1 and decreased both the expression of aromatase and the oestradiol level.	Quercetin	15-24	nucleobindin 2	Rattus norvegicus	87-97
31689533-0	2020	Efficacy of Quercetin as a potent sensitizer of beta2-AR in combating the impairment of fluid clearance in lungs of rats under hypoxia.	Quercetin	12-21	adenosine A2a receptor	Rattus norvegicus	48-56
31689533-2	2020	The present study correlates the prophylactic potential of quercetin and salbutamol in ameliorating fluid clearing capacity of lungs by re-sensitizing beta2-AR signaling under hypoxia.	Quercetin	59-68	adenosine A2a receptor	Rattus norvegicus	151-159
31689533-5	2020	RESULTS: Quercetin and salbutamol pre-treatment significantly up-regulated the expressions of beta2-AR, GPR-1, GPR-10, GCSalpha, cAMP content, and down-regulated GRK-2, beta-arrestin, ROS, NFkappaB (p < 0.001), thus, enhancing alveolar fluid clearance (AFC).	Quercetin	9-18	adenosine A2a receptor	Rattus norvegicus	94-102
31689533-5	2020	RESULTS: Quercetin and salbutamol pre-treatment significantly up-regulated the expressions of beta2-AR, GPR-1, GPR-10, GCSalpha, cAMP content, and down-regulated GRK-2, beta-arrestin, ROS, NFkappaB (p < 0.001), thus, enhancing alveolar fluid clearance (AFC).	Quercetin	9-18	chemerin chemokine-like receptor 2	Rattus norvegicus	104-109
31689533-5	2020	RESULTS: Quercetin and salbutamol pre-treatment significantly up-regulated the expressions of beta2-AR, GPR-1, GPR-10, GCSalpha, cAMP content, and down-regulated GRK-2, beta-arrestin, ROS, NFkappaB (p < 0.001), thus, enhancing alveolar fluid clearance (AFC).	Quercetin	9-18	prolactin releasing hormone receptor	Rattus norvegicus	111-117
31689533-5	2020	RESULTS: Quercetin and salbutamol pre-treatment significantly up-regulated the expressions of beta2-AR, GPR-1, GPR-10, GCSalpha, cAMP content, and down-regulated GRK-2, beta-arrestin, ROS, NFkappaB (p < 0.001), thus, enhancing alveolar fluid clearance (AFC).	Quercetin	9-18	G protein-coupled receptor kinase 2	Rattus norvegicus	162-167
31689533-6	2020	SPR and insilico findings revealed a higher binding affinity of beta2-AR with quercetin over salbutamol.	Quercetin	78-87	adenosine A2a receptor	Rattus norvegicus	64-72
31689533-7	2020	CONCLUSION: Results indicated quercetin to be a better prophylactic that augmented AFC in rats exposed to hypoxia by attenuating inflammation and stimulating beta2-AR.	Quercetin	30-39	adenosine A2a receptor	Rattus norvegicus	158-166
32029167-11	2020	Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-alpha, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-kappaBp65), and interferon-gamma (IFN-gamma) mRNA (P < 0.05), and expression of NF-kappaB inhibitor-alpha (IkappaB-alpha) mRNA were significantly decreased (P < 0.05).	Quercetin	34-43	lipopolysaccharide induced TNF factor	Gallus gallus	98-107
32029167-11	2020	Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-alpha, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-kappaBp65), and interferon-gamma (IFN-gamma) mRNA (P < 0.05), and expression of NF-kappaB inhibitor-alpha (IkappaB-alpha) mRNA were significantly decreased (P < 0.05).	Quercetin	34-43	TNF receptor associated factor 2	Gallus gallus	109-141
32029167-11	2020	Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-alpha, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-kappaBp65), and interferon-gamma (IFN-gamma) mRNA (P < 0.05), and expression of NF-kappaB inhibitor-alpha (IkappaB-alpha) mRNA were significantly decreased (P < 0.05).	Quercetin	34-43	TNF receptor associated factor 2	Gallus gallus	143-149
32029167-11	2020	Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-alpha, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-kappaBp65), and interferon-gamma (IFN-gamma) mRNA (P < 0.05), and expression of NF-kappaB inhibitor-alpha (IkappaB-alpha) mRNA were significantly decreased (P < 0.05).	Quercetin	34-43	TNF receptor superfamily member 1B	Gallus gallus	152-186
32029167-11	2020	Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-alpha, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-kappaBp65), and interferon-gamma (IFN-gamma) mRNA (P < 0.05), and expression of NF-kappaB inhibitor-alpha (IkappaB-alpha) mRNA were significantly decreased (P < 0.05).	Quercetin	34-43	TNF receptor superfamily member 1B	Gallus gallus	188-196
32029167-11	2020	Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-alpha, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-kappaBp65), and interferon-gamma (IFN-gamma) mRNA (P < 0.05), and expression of NF-kappaB inhibitor-alpha (IkappaB-alpha) mRNA were significantly decreased (P < 0.05).	Quercetin	34-43	interferon gamma	Gallus gallus	254-270
32029167-11	2020	Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-alpha, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-kappaBp65), and interferon-gamma (IFN-gamma) mRNA (P < 0.05), and expression of NF-kappaB inhibitor-alpha (IkappaB-alpha) mRNA were significantly decreased (P < 0.05).	Quercetin	34-43	interferon gamma	Gallus gallus	272-281
32029167-11	2020	Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-alpha, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-kappaBp65), and interferon-gamma (IFN-gamma) mRNA (P < 0.05), and expression of NF-kappaB inhibitor-alpha (IkappaB-alpha) mRNA were significantly decreased (P < 0.05).	Quercetin	34-43	NFKB inhibitor alpha	Gallus gallus	318-343
32029167-11	2020	Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-alpha, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-kappaBp65), and interferon-gamma (IFN-gamma) mRNA (P < 0.05), and expression of NF-kappaB inhibitor-alpha (IkappaB-alpha) mRNA were significantly decreased (P < 0.05).	Quercetin	34-43	NFKB inhibitor alpha	Gallus gallus	345-358
32029167-12	2020	Thus, quercetin improved immune function via NF-kappaB signaling pathway triggered by TNF-alpha.	Quercetin	6-15	lipopolysaccharide induced TNF factor	Gallus gallus	86-95
31874239-0	2020	Quercetin attenuates decrease of thioredoxin expression following focal cerebral ischemia and glutamate-induced neuronal cell damage.	Quercetin	0-9	thioredoxin 1	Rattus norvegicus	33-44
31585131-8	2020	Against the background of the identified changes quercetin exerted significant effects on the lipid and nitrogen metabolism indices such as HDL cholesterol, AsAT/AlAT activities ratio, urea level as well as body and fat mass that were different in Z and W rats.	Quercetin	49-58	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	157-161
32023875-0	2020	Quercetin and Coumarin Inhibit Dipeptidyl Peptidase-IV and Exhibits Antioxidant Properties: In Silico, In Vitro, Ex Vivo.	Quercetin	0-9	dipeptidyl peptidase 4	Homo sapiens	31-54
32023875-2	2020	The present study was designed to evaluate the inhibitory activity of quercetin and coumarin on dipeptidyl peptidase-IV (DPP-IV) and their antioxidant potential.	Quercetin	70-79	dipeptidyl peptidase 4	Homo sapiens	96-119
32023875-2	2020	The present study was designed to evaluate the inhibitory activity of quercetin and coumarin on dipeptidyl peptidase-IV (DPP-IV) and their antioxidant potential.	Quercetin	70-79	dipeptidyl peptidase 4	Homo sapiens	121-127
32023875-4	2020	Furthermore, in silico studies such as the drug-likeliness and docking efficiency of quercetin and coumarin to the DPP-IV protein were performed; the ex vivo antiperoxidative potential of quercetin and coumarin were also evaluated.	Quercetin	85-94	dipeptidyl peptidase 4	Homo sapiens	115-121
32023875-4	2020	Furthermore, in silico studies such as the drug-likeliness and docking efficiency of quercetin and coumarin to the DPP-IV protein were performed; the ex vivo antiperoxidative potential of quercetin and coumarin were also evaluated.	Quercetin	188-197	dipeptidyl peptidase 4	Homo sapiens	115-121
32023875-5	2020	The results of the present study showed that the DPP-IV inhibitory potential of quercetin was slightly higher than that of sitagliptin.	Quercetin	80-89	dipeptidyl peptidase 4	Homo sapiens	49-55
32023875-6	2020	Virtual docking revealed the tight binding of quercetin with DPP-IV protein.	Quercetin	46-55	dipeptidyl peptidase 4	Homo sapiens	61-67
32012739-0	2020	Analysis of Binding Interactions of Ramipril and Quercetin on Human Serum Albumin: A Novel Method in Affinity Evaluation.	Quercetin	49-58	albumin	Homo sapiens	68-81
32012739-1	2020	The aim of this study was to analyze the binding interactions between a common antihypertensive drug (ramipril, R) and the widely distributed plant flavonoid quercetin (Q), in the presence of human serum albumin (HSA).	Quercetin	158-167	albumin	Homo sapiens	198-211
32158203-14	2020	In particular, hsa04750 (inflammatory mediator regulation of TRP channels)-C00469 (ethanol) and hsa04152 (AMPK signaling pathway)-C00389 (quercetin) pairs were found in the metabolite network.	Quercetin	138-147	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	106-110
31874239-15	2020	Our findings suggest that quercetin mediates its neuroprotective function by regulation of thioredoxin expression and maintenance of interaction between ASK1 and thioredoxin.	Quercetin	26-35	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	153-157
31874239-15	2020	Our findings suggest that quercetin mediates its neuroprotective function by regulation of thioredoxin expression and maintenance of interaction between ASK1 and thioredoxin.	Quercetin	26-35	thioredoxin 1	Rattus norvegicus	162-173
31874239-4	2020	This study investigated whether quercetin regulates thioredoxin expression in focal cerebral ischemia and glutamate-induced neuronal cell death.	Quercetin	32-41	thioredoxin 1	Rattus norvegicus	52-63
31874239-8	2020	We observed the change of thioredoxin expression in MCAO animals with quercetin using proteomic approach, reverse-transcription PCR, and Western blot analyses.	Quercetin	70-79	thioredoxin 1	Rattus norvegicus	26-37
31874239-10	2020	Moreover, quercetin treatment alleviated the decrease in the number of thioredoxin-positive cells in cerebral cortex of MCAO animals.	Quercetin	10-19	thioredoxin 1	Rattus norvegicus	71-82
31874239-11	2020	Furthermore, immunoprecipitation analysis demonstrated that interaction of apoptosis signal-regulating kinase 1 (ASK1) and thioredoxin was decreased in MCAO animals with vehicle, while quercetin prevented MCAO-induced decrease in these binding.	Quercetin	185-194	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	113-117
31874239-12	2020	In addition, quercetin also alleviated the reduction of cell viability and the decrease in thioredoxin expression in glutamate-treated hippocampal cell line and primary cultures of cortical neurons.	Quercetin	13-22	thioredoxin 1	Rattus norvegicus	91-102
31874239-13	2020	However in thioredoxin-silenced cortical neuron, anti-apoptotic effect of quercetin was decreased.	Quercetin	74-83	thioredoxin 1	Rattus norvegicus	11-22
31874239-14	2020	Thus, changes of thioredoxin expression by quercetin may contribute to the neuroprotective effect of quercetin in focal cerebral ischemia.	Quercetin	43-52	thioredoxin 1	Rattus norvegicus	17-28
31874239-14	2020	Thus, changes of thioredoxin expression by quercetin may contribute to the neuroprotective effect of quercetin in focal cerebral ischemia.	Quercetin	101-110	thioredoxin 1	Rattus norvegicus	17-28
31874239-15	2020	Our findings suggest that quercetin mediates its neuroprotective function by regulation of thioredoxin expression and maintenance of interaction between ASK1 and thioredoxin.	Quercetin	26-35	thioredoxin 1	Rattus norvegicus	91-102
32667589-6	2020	Results Quercetin significantly increased hydroxyproline, superoxide dismutase, catalase levels, histopathological healing score, bursting pressure values and decreased malondialdehyde level in early period.	Quercetin	8-17	catalase	Rattus norvegicus	80-88
31929529-6	2020	A total of thirteen compounds were identified in HECA, mainly quercetin, kaempferol and glucoside derivatives of both, besides catechin and epicatechin known as wound healing agents.	Quercetin	62-71	hdc homolog, cell cycle regulator	Mus musculus	49-53
31880932-1	2020	4G-alpha-Glucopyranosylrutin (monoglucosylrutin, MGR) is a flavonol glycoside with quercetin as an aglycone, is pale yellow in color, and engages in both copigmentation and anticopigmentation.	Quercetin	83-92	MGR6	Homo sapiens	49-52
32009956-0	2019	Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC.	Quercetin	0-9	brain-derived neurotrophic factor	Rattus norvegicus	81-85
32009956-0	2019	Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC.	Quercetin	0-9	copine 6	Rattus norvegicus	107-115
32009956-0	2019	Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC.	Quercetin	0-9	triggering receptor expressed on myeloid cells 1	Rattus norvegicus	120-127
32009956-8	2019	The results suggested that quercetin could alleviate LPS-induced depression-like behaviors and impairment of learning and memory in rats, the mechanism of which might be involved with regulating the BDNF-related imbalance expression of Copine 6 and TREM1/2 in the hippocampus and the PFC.	Quercetin	27-36	brain-derived neurotrophic factor	Rattus norvegicus	199-203
32009956-8	2019	The results suggested that quercetin could alleviate LPS-induced depression-like behaviors and impairment of learning and memory in rats, the mechanism of which might be involved with regulating the BDNF-related imbalance expression of Copine 6 and TREM1/2 in the hippocampus and the PFC.	Quercetin	27-36	copine 6	Rattus norvegicus	236-244
32009956-8	2019	The results suggested that quercetin could alleviate LPS-induced depression-like behaviors and impairment of learning and memory in rats, the mechanism of which might be involved with regulating the BDNF-related imbalance expression of Copine 6 and TREM1/2 in the hippocampus and the PFC.	Quercetin	27-36	triggering receptor expressed on myeloid cells 1	Rattus norvegicus	249-256
31941501-8	2020	Besides, the CMC of amphiphilic polymers, the quercetin (QC) feeding ratio and polarity of solvents determined the QC loading ratio maximized reaching 29.2% certified by UV spectrum, together with the corresponding size and stability changes by DLS and Zeta potential, and thermodynamic changes by TGA and DSC.	Quercetin	115-117	T-box transcription factor 1	Homo sapiens	298-301
32025234-7	2020	Network analysis showed PTGS2, ESR1, and NOS2 to be the three key targets, and beta-sitosterol, quercetin, and berberine were the three major active ingredients; among them one of the major active ingredients, quercetin, was discriminated by TLC.	Quercetin	210-219	prostaglandin-endoperoxide synthase 2	Homo sapiens	24-29
32025234-7	2020	Network analysis showed PTGS2, ESR1, and NOS2 to be the three key targets, and beta-sitosterol, quercetin, and berberine were the three major active ingredients; among them one of the major active ingredients, quercetin, was discriminated by TLC.	Quercetin	210-219	estrogen receptor 1	Homo sapiens	31-35
32025234-7	2020	Network analysis showed PTGS2, ESR1, and NOS2 to be the three key targets, and beta-sitosterol, quercetin, and berberine were the three major active ingredients; among them one of the major active ingredients, quercetin, was discriminated by TLC.	Quercetin	210-219	nitric oxide synthase 2	Homo sapiens	41-45
32685032-0	2020	Quercetin and Isoquercitrin Inhibiting Hepatic Gluconeogenesis Through LKB1-AMPKalpha Pathway.	Quercetin	0-9	serine/threonine kinase 11	Mus musculus	71-75
33200026-0	2020	Chinese herbal compounds against SARS-CoV-2: puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor.	Quercetin	58-67	vitronectin	Homo sapiens	96-105
32685032-9	2020	The effects of quercetin and isoquercitrin on LKB1 and AMPKalpha were similar to those of metformin.	Quercetin	15-24	serine/threonine kinase 11	Mus musculus	46-50
32685032-10	2020	Conclusions: Quercetin and isoquercitrin inhibit gluconeogenesis in hepatocytes, which may be related to the LKB1 upregulation and phosphorylation of AMPKalpha.	Quercetin	13-22	serine/threonine kinase 11	Mus musculus	109-113
32086110-8	2020	Although these phytochemicals did not modify telencephalic interleukin 6 production, quercetin augmented 2.51 fold interleukin 6 in the diencephalon, whereas 5 caffeoylquinic acid decreased it 0.43 fold.	Quercetin	85-94	interleukin 6	Mus musculus	115-128
32468451-8	2020	In silico molecular docking studies have also shown that quercetin could be an ideal potential drug target for aromatic L-amino acid decarboxylase and human catechol-O-methyltransferase.	Quercetin	57-66	dopa decarboxylase	Homo sapiens	111-146
32468451-8	2020	In silico molecular docking studies have also shown that quercetin could be an ideal potential drug target for aromatic L-amino acid decarboxylase and human catechol-O-methyltransferase.	Quercetin	57-66	catechol-O-methyltransferase	Homo sapiens	157-185
33200026-0	2020	Chinese herbal compounds against SARS-CoV-2: puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor.	Quercetin	58-67	angiotensin converting enzyme 2	Homo sapiens	109-113
33200026-4	2020	Molecular docking analysis showed that puerarin and quercetin exhibit good binding affinity to ACE2, which was validated by surface plasmon resonance (SPR) assay.	Quercetin	52-61	angiotensin converting enzyme 2	Homo sapiens	95-99
33200026-5	2020	Furthermore, SPR-based competition assay revealed that puerarin and quercetin could significantly affect the binding of viral S-protein to ACE2 receptor.	Quercetin	68-77	vitronectin	Homo sapiens	126-135
33200026-5	2020	Furthermore, SPR-based competition assay revealed that puerarin and quercetin could significantly affect the binding of viral S-protein to ACE2 receptor.	Quercetin	68-77	angiotensin converting enzyme 2	Homo sapiens	139-143
33200026-6	2020	Notably, quercetin could also bind to the RBD domain of S-protein, suggesting not only a receptor blocking, but also a virus neutralizing effect of quercetin on SARS-CoV-2.	Quercetin	9-18	vitronectin	Homo sapiens	56-65
33200026-6	2020	Notably, quercetin could also bind to the RBD domain of S-protein, suggesting not only a receptor blocking, but also a virus neutralizing effect of quercetin on SARS-CoV-2.	Quercetin	148-157	vitronectin	Homo sapiens	56-65
31672514-0	2020	Quercetin as a Lyn kinase inhibitor inhibits IgE-mediated allergic conjunctivitis.	Quercetin	0-9	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
32640958-1	2020	OBJECTIVE: Quercetin was parcelled by beta-cyclodextrin (beta-CD) to prepare the sustained-release complex, and the effect of beta-CD-quercetin complex on the growth of ethanol-injuried hepatocytes was studied.	Quercetin	134-143	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	126-133
32640958-7	2020	CONCLUSION: Quercetin sustained-release complex could be prepared with beta-CD, and they might be used to treat alcoholic liver injury.	Quercetin	12-21	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	71-78
32735523-7	2020	We have also performed Western Blot analysis by pre-treating the cells with quercetin, a known ATM upregulator by causing DNA double-strand breaks.	Quercetin	76-85	ATM serine/threonine kinase	Homo sapiens	95-98
30968779-9	2020	CONCLUSION: Quercetin has strong binding affinity towards CD4, CD8 and CD28, CD45 receptors and protects the thymocytes and splenocytes against DLM-induced apoptotic signaling pathways.	Quercetin	12-21	CD4 molecule	Homo sapiens	58-61
30968779-9	2020	CONCLUSION: Quercetin has strong binding affinity towards CD4, CD8 and CD28, CD45 receptors and protects the thymocytes and splenocytes against DLM-induced apoptotic signaling pathways.	Quercetin	12-21	CD8a molecule	Homo sapiens	63-66
31672514-9	2020	Quercetin (200 muM) and Lyn inhibitors (Bafetinib, 10 muM) inhibit the activity of Lyn kinase, and quercetin can reduce the activation of Lyn kinase by Lyn agonist (Tolimidone, 10 muM).	Quercetin	0-9	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	83-86
31672514-9	2020	Quercetin (200 muM) and Lyn inhibitors (Bafetinib, 10 muM) inhibit the activity of Lyn kinase, and quercetin can reduce the activation of Lyn kinase by Lyn agonist (Tolimidone, 10 muM).	Quercetin	0-9	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	83-86
31672514-9	2020	Quercetin (200 muM) and Lyn inhibitors (Bafetinib, 10 muM) inhibit the activity of Lyn kinase, and quercetin can reduce the activation of Lyn kinase by Lyn agonist (Tolimidone, 10 muM).	Quercetin	0-9	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	83-86
31672514-10	2020	These data can be preliminarily determined that quercetin can inhibit allergic conjunctivitis as a Lyn kinase inhibitor.	Quercetin	48-57	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	99-102
31672514-11	2020	CONCLUSIONS AND IMPLICATIONS: This study illustrated the use of quercetin for the treatment of allergic conjunctivitis, which might act through its ability to inhibit Lyn/PLCgamma/IP3R-Ca2+, Lyn/ERK1/2, and Lyn/NF-kappaB signaling.	Quercetin	64-73	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	167-170
31672514-11	2020	CONCLUSIONS AND IMPLICATIONS: This study illustrated the use of quercetin for the treatment of allergic conjunctivitis, which might act through its ability to inhibit Lyn/PLCgamma/IP3R-Ca2+, Lyn/ERK1/2, and Lyn/NF-kappaB signaling.	Quercetin	64-73	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	180-184
31672514-4	2020	KEY RESULTS: Quercetin inhibited the ovalbumin (OVA) induced expression of IgE, HA, IL-4, TNF-alpha and substance-P in the peripheral blood of AC mouse models.	Quercetin	13-22	interleukin 4	Mus musculus	84-88
31672514-11	2020	CONCLUSIONS AND IMPLICATIONS: This study illustrated the use of quercetin for the treatment of allergic conjunctivitis, which might act through its ability to inhibit Lyn/PLCgamma/IP3R-Ca2+, Lyn/ERK1/2, and Lyn/NF-kappaB signaling.	Quercetin	64-73	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	191-194
31672514-11	2020	CONCLUSIONS AND IMPLICATIONS: This study illustrated the use of quercetin for the treatment of allergic conjunctivitis, which might act through its ability to inhibit Lyn/PLCgamma/IP3R-Ca2+, Lyn/ERK1/2, and Lyn/NF-kappaB signaling.	Quercetin	64-73	mitogen-activated protein kinase 3	Homo sapiens	195-201
31672514-4	2020	KEY RESULTS: Quercetin inhibited the ovalbumin (OVA) induced expression of IgE, HA, IL-4, TNF-alpha and substance-P in the peripheral blood of AC mouse models.	Quercetin	13-22	tumor necrosis factor	Mus musculus	90-99
31672514-11	2020	CONCLUSIONS AND IMPLICATIONS: This study illustrated the use of quercetin for the treatment of allergic conjunctivitis, which might act through its ability to inhibit Lyn/PLCgamma/IP3R-Ca2+, Lyn/ERK1/2, and Lyn/NF-kappaB signaling.	Quercetin	64-73	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	191-194
31672514-11	2020	CONCLUSIONS AND IMPLICATIONS: This study illustrated the use of quercetin for the treatment of allergic conjunctivitis, which might act through its ability to inhibit Lyn/PLCgamma/IP3R-Ca2+, Lyn/ERK1/2, and Lyn/NF-kappaB signaling.	Quercetin	64-73	nuclear factor kappa B subunit 1	Homo sapiens	211-220
31672514-5	2020	Quercetin also attenuated OVA induced MC degranulation, eosinophil number, substance P concentrations, and mRNA IL-4/TNF-alpha expression in the conjunctival tissue of AC models.	Quercetin	0-9	tachykinin precursor 1	Homo sapiens	75-86
31672514-12	2020	The inhibition of Lyn likely represents a major mechanism by which quercetin dampens the inflammatory response in AC disease models.	Quercetin	67-76	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-21
31672514-5	2020	Quercetin also attenuated OVA induced MC degranulation, eosinophil number, substance P concentrations, and mRNA IL-4/TNF-alpha expression in the conjunctival tissue of AC models.	Quercetin	0-9	interleukin 4	Homo sapiens	112-116
31672514-5	2020	Quercetin also attenuated OVA induced MC degranulation, eosinophil number, substance P concentrations, and mRNA IL-4/TNF-alpha expression in the conjunctival tissue of AC models.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	117-126
31672514-7	2020	Quercetin also inhibited DNP-HSA/IgE induced Lyn/PLCgamma/IP3R-Ca2+ activation, Lyn/ERK1/2 signaling, and Lyn/NF-kappaB activation in LAD2 cells, all of which promote inflammation.	Quercetin	0-9	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
31672514-7	2020	Quercetin also inhibited DNP-HSA/IgE induced Lyn/PLCgamma/IP3R-Ca2+ activation, Lyn/ERK1/2 signaling, and Lyn/NF-kappaB activation in LAD2 cells, all of which promote inflammation.	Quercetin	0-9	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	58-62
31672514-7	2020	Quercetin also inhibited DNP-HSA/IgE induced Lyn/PLCgamma/IP3R-Ca2+ activation, Lyn/ERK1/2 signaling, and Lyn/NF-kappaB activation in LAD2 cells, all of which promote inflammation.	Quercetin	0-9	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
31672514-7	2020	Quercetin also inhibited DNP-HSA/IgE induced Lyn/PLCgamma/IP3R-Ca2+ activation, Lyn/ERK1/2 signaling, and Lyn/NF-kappaB activation in LAD2 cells, all of which promote inflammation.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	84-90
31672514-7	2020	Quercetin also inhibited DNP-HSA/IgE induced Lyn/PLCgamma/IP3R-Ca2+ activation, Lyn/ERK1/2 signaling, and Lyn/NF-kappaB activation in LAD2 cells, all of which promote inflammation.	Quercetin	0-9	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
31672514-7	2020	Quercetin also inhibited DNP-HSA/IgE induced Lyn/PLCgamma/IP3R-Ca2+ activation, Lyn/ERK1/2 signaling, and Lyn/NF-kappaB activation in LAD2 cells, all of which promote inflammation.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	110-119
31672514-8	2020	When added alone, quercetin had no effect on PLCgamma1 phosphorylation or expression, but potently inhibited Lyn and phosphorylation-Lyn.	Quercetin	18-27	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	109-112
31672514-8	2020	When added alone, quercetin had no effect on PLCgamma1 phosphorylation or expression, but potently inhibited Lyn and phosphorylation-Lyn.	Quercetin	18-27	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	133-136
31672514-9	2020	Quercetin (200 muM) and Lyn inhibitors (Bafetinib, 10 muM) inhibit the activity of Lyn kinase, and quercetin can reduce the activation of Lyn kinase by Lyn agonist (Tolimidone, 10 muM).	Quercetin	0-9	latexin	Homo sapiens	15-18
31629796-0	2020	Quercetin a major biomarker of Psidium guajava L. inhibits SepA protease activity of Shigella flexneri in treatment of infectious diarrhoea.	Quercetin	0-9	SepA	Shigella flexneri	59-63
32863301-9	2020	Moreover, polyphenols such as cyanidin-3-glucoside chloride and quercetin enhanced the SVCT1 gene expression in Caco-2 cells.	Quercetin	64-73	solute carrier family 23 member 1	Homo sapiens	87-92
31629796-8	2020	Molecular docking studies on crystal structure of Secreted Extracellular Protein A (SepA) from Shigella flexneri with biomarker quercetin was also performed.	Quercetin	128-137	SepA	Shigella flexneri	84-88
31629796-12	2020	Docking simulation studies revealed the role of quercetin in inactivating the protease activity of SepA, a protein secreted by Shigella, which disrupts epithelial barrier integrity during infection and also manages its signal production.	Quercetin	48-57	SepA	Shigella flexneri	99-103
31944087-15	2020	CONCLUSION: The FLS, an enzyme which plays an important role in producing quercetin, was detected in B. rotunda rhizome planted in Indonesia.	Quercetin	74-83	flavonol synthase 1	Arabidopsis thaliana	16-19
31673888-15	2020	However, tissue MDA, PC, and CL levels decreased in the EQ group compared to group E. GSH level, GP, GR, SOD, and CAT activity were significantly increased by quercetin (P < 0.05-P < 0.001).	Quercetin	159-168	glutathione-disulfide reductase	Rattus norvegicus	101-103
31673888-15	2020	However, tissue MDA, PC, and CL levels decreased in the EQ group compared to group E. GSH level, GP, GR, SOD, and CAT activity were significantly increased by quercetin (P < 0.05-P < 0.001).	Quercetin	159-168	catalase	Rattus norvegicus	114-117
31673888-17	2020	The TNFalpha, IL-1beta, and IL-6 levels and NF-kappaB activation significantly decreased in group EQ compared to group E. In conclusion, quercetin has a protective effect against maternal alcohol-induced oxidative and inflammatory damage in the liver and lymphoid tissues of newborn rats.	Quercetin	137-146	tumor necrosis factor	Rattus norvegicus	4-12
31673888-17	2020	The TNFalpha, IL-1beta, and IL-6 levels and NF-kappaB activation significantly decreased in group EQ compared to group E. In conclusion, quercetin has a protective effect against maternal alcohol-induced oxidative and inflammatory damage in the liver and lymphoid tissues of newborn rats.	Quercetin	137-146	interleukin 1 alpha	Rattus norvegicus	14-22
31673888-17	2020	The TNFalpha, IL-1beta, and IL-6 levels and NF-kappaB activation significantly decreased in group EQ compared to group E. In conclusion, quercetin has a protective effect against maternal alcohol-induced oxidative and inflammatory damage in the liver and lymphoid tissues of newborn rats.	Quercetin	137-146	interleukin 6	Rattus norvegicus	28-32
31595775-2	2020	The aim of this study was to investigate the effect of resveratrol and quercetin on epithelial-mesenchymal transition (EMT) of CD133+ and CD133- pancreatic cancer cells.	Quercetin	71-80	prominin 1	Homo sapiens	127-132
31595775-2	2020	The aim of this study was to investigate the effect of resveratrol and quercetin on epithelial-mesenchymal transition (EMT) of CD133+ and CD133- pancreatic cancer cells.	Quercetin	71-80	prominin 1	Homo sapiens	138-143
31595775-8	2020	ACTA-2, IL-1beta, and N-cadherin immunoreactivities were significantly decreased, whereas TNF-alpha and vimentin immunoreactivities significantly increased in quercetin-treated CD133+ cells.	Quercetin	159-168	actin alpha 2, smooth muscle	Homo sapiens	0-6
31595775-8	2020	ACTA-2, IL-1beta, and N-cadherin immunoreactivities were significantly decreased, whereas TNF-alpha and vimentin immunoreactivities significantly increased in quercetin-treated CD133+ cells.	Quercetin	159-168	interleukin 1 beta	Homo sapiens	8-16
31595775-8	2020	ACTA-2, IL-1beta, and N-cadherin immunoreactivities were significantly decreased, whereas TNF-alpha and vimentin immunoreactivities significantly increased in quercetin-treated CD133+ cells.	Quercetin	159-168	cadherin 2	Homo sapiens	22-32
31595775-8	2020	ACTA-2, IL-1beta, and N-cadherin immunoreactivities were significantly decreased, whereas TNF-alpha and vimentin immunoreactivities significantly increased in quercetin-treated CD133+ cells.	Quercetin	159-168	tumor necrosis factor	Homo sapiens	90-99
31595775-8	2020	ACTA-2, IL-1beta, and N-cadherin immunoreactivities were significantly decreased, whereas TNF-alpha and vimentin immunoreactivities significantly increased in quercetin-treated CD133+ cells.	Quercetin	159-168	vimentin	Homo sapiens	104-112
31595775-8	2020	ACTA-2, IL-1beta, and N-cadherin immunoreactivities were significantly decreased, whereas TNF-alpha and vimentin immunoreactivities significantly increased in quercetin-treated CD133+ cells.	Quercetin	159-168	prominin 1	Homo sapiens	177-182
31595775-10	2020	The reduction in N-cadherin and ACTA-2 immunoreactivities was higher than the increase in vimentin immunoreactivity, quercetin could prevent EMT to a greater extent than resveratrol in pancreatic cancer stem cells because of the reduced expression of N-cadherin.	Quercetin	117-126	cadherin 2	Homo sapiens	251-261
31497913-0	2020	Quercetin protects against cisplatin-induced acute kidney injury by inhibiting Mincle/Syk/NF-kappaB signaling maintained macrophage inflammation.	Quercetin	0-9	C-type lectin domain family 4 member E	Homo sapiens	79-85
31609578-2	2019	Pirin proteins typically function as nuclear transcription regulators, but two Pirin orthologs, YhhW (from Escherichia coli) and hPirin (from humans) were revealed to possess enzymatic activity of degrading quercetin.	Quercetin	207-216	pirin	Homo sapiens	0-5
31497913-0	2020	Quercetin protects against cisplatin-induced acute kidney injury by inhibiting Mincle/Syk/NF-kappaB signaling maintained macrophage inflammation.	Quercetin	0-9	spleen associated tyrosine kinase	Homo sapiens	86-89
31497913-0	2020	Quercetin protects against cisplatin-induced acute kidney injury by inhibiting Mincle/Syk/NF-kappaB signaling maintained macrophage inflammation.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	90-99
31497913-4	2020	In this study, we try to explore whether quercetin protects against AKI by inhibiting macrophage inflammation via regulation of Mincle/Syk/NF-kappaB signaling.	Quercetin	41-50	C-type lectin domain family 4 member E	Homo sapiens	128-134
31497913-4	2020	In this study, we try to explore whether quercetin protects against AKI by inhibiting macrophage inflammation via regulation of Mincle/Syk/NF-kappaB signaling.	Quercetin	41-50	spleen associated tyrosine kinase	Homo sapiens	135-138
31497913-4	2020	In this study, we try to explore whether quercetin protects against AKI by inhibiting macrophage inflammation via regulation of Mincle/Syk/NF-kappaB signaling.	Quercetin	41-50	nuclear factor kappa B subunit 1	Homo sapiens	139-148
31497913-5	2020	The results demonstrated that quercetin can significantly inhibit expression and secretion of IL-1beta, IL-6, and TNF-alpha in LPS-induced bone marrow-derived macrophages (BMDMs) and reduce activity of Mincle/Syk/NF-kappaB signaling in vitro.	Quercetin	30-39	interleukin 1 beta	Homo sapiens	94-102
31497913-5	2020	The results demonstrated that quercetin can significantly inhibit expression and secretion of IL-1beta, IL-6, and TNF-alpha in LPS-induced bone marrow-derived macrophages (BMDMs) and reduce activity of Mincle/Syk/NF-kappaB signaling in vitro.	Quercetin	30-39	interleukin 6	Homo sapiens	104-108
31497913-5	2020	The results demonstrated that quercetin can significantly inhibit expression and secretion of IL-1beta, IL-6, and TNF-alpha in LPS-induced bone marrow-derived macrophages (BMDMs) and reduce activity of Mincle/Syk/NF-kappaB signaling in vitro.	Quercetin	30-39	tumor necrosis factor	Homo sapiens	114-123
31497913-5	2020	The results demonstrated that quercetin can significantly inhibit expression and secretion of IL-1beta, IL-6, and TNF-alpha in LPS-induced bone marrow-derived macrophages (BMDMs) and reduce activity of Mincle/Syk/NF-kappaB signaling in vitro.	Quercetin	30-39	C-type lectin domain family 4 member E	Homo sapiens	202-208
31497913-5	2020	The results demonstrated that quercetin can significantly inhibit expression and secretion of IL-1beta, IL-6, and TNF-alpha in LPS-induced bone marrow-derived macrophages (BMDMs) and reduce activity of Mincle/Syk/NF-kappaB signaling in vitro.	Quercetin	30-39	spleen associated tyrosine kinase	Homo sapiens	209-212
31497913-5	2020	The results demonstrated that quercetin can significantly inhibit expression and secretion of IL-1beta, IL-6, and TNF-alpha in LPS-induced bone marrow-derived macrophages (BMDMs) and reduce activity of Mincle/Syk/NF-kappaB signaling in vitro.	Quercetin	30-39	nuclear factor kappa B subunit 1	Homo sapiens	213-222
31497913-6	2020	We also found that quercetin can strongly reduce the concentration of serum creatinine, BUN, IL-1beta, IL-6, and TNF-alpha in cisplatin-induced AKI model.	Quercetin	19-28	interleukin 1 beta	Homo sapiens	93-101
31497913-6	2020	We also found that quercetin can strongly reduce the concentration of serum creatinine, BUN, IL-1beta, IL-6, and TNF-alpha in cisplatin-induced AKI model.	Quercetin	19-28	interleukin 6	Homo sapiens	103-107
31497913-6	2020	We also found that quercetin can strongly reduce the concentration of serum creatinine, BUN, IL-1beta, IL-6, and TNF-alpha in cisplatin-induced AKI model.	Quercetin	19-28	tumor necrosis factor	Homo sapiens	113-122
31622846-0	2020	AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts.	Quercetin	51-60	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	0-4
31497913-7	2020	Furthermore, quercetin down-regulated protein levels of Mincle, phosphorylated Syk and NF-kappaB in kidney macrophages of AKI, as well as inhibited M1, up-regulated M2 macrophage activity.	Quercetin	13-22	C-type lectin domain family 4 member E	Homo sapiens	56-62
31497913-7	2020	Furthermore, quercetin down-regulated protein levels of Mincle, phosphorylated Syk and NF-kappaB in kidney macrophages of AKI, as well as inhibited M1, up-regulated M2 macrophage activity.	Quercetin	13-22	spleen associated tyrosine kinase	Homo sapiens	79-82
31497913-7	2020	Furthermore, quercetin down-regulated protein levels of Mincle, phosphorylated Syk and NF-kappaB in kidney macrophages of AKI, as well as inhibited M1, up-regulated M2 macrophage activity.	Quercetin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	87-96
31497913-8	2020	Notably, the down-regulation of LPS-induced inflammation by quercetin was reversed after adding TDB (an agonist of Mincle) in BMDMs, suggesting that quercetin suppresses macrophage inflammation may mainly through inhibiting Mincle and its downstream signaling.	Quercetin	60-69	C-type lectin domain family 4 member E	Homo sapiens	224-230
31497913-8	2020	Notably, the down-regulation of LPS-induced inflammation by quercetin was reversed after adding TDB (an agonist of Mincle) in BMDMs, suggesting that quercetin suppresses macrophage inflammation may mainly through inhibiting Mincle and its downstream signaling.	Quercetin	149-158	C-type lectin domain family 4 member E	Homo sapiens	115-121
31497913-8	2020	Notably, the down-regulation of LPS-induced inflammation by quercetin was reversed after adding TDB (an agonist of Mincle) in BMDMs, suggesting that quercetin suppresses macrophage inflammation may mainly through inhibiting Mincle and its downstream signaling.	Quercetin	149-158	C-type lectin domain family 4 member E	Homo sapiens	224-230
31609578-2	2019	Pirin proteins typically function as nuclear transcription regulators, but two Pirin orthologs, YhhW (from Escherichia coli) and hPirin (from humans) were revealed to possess enzymatic activity of degrading quercetin.	Quercetin	207-216	pirin	Homo sapiens	79-84
31609578-2	2019	Pirin proteins typically function as nuclear transcription regulators, but two Pirin orthologs, YhhW (from Escherichia coli) and hPirin (from humans) were revealed to possess enzymatic activity of degrading quercetin.	Quercetin	207-216	pirin	Homo sapiens	129-135
31610186-5	2019	Quercetin caused further increase in LPS-induced IL-6 and IL-8 levels.	Quercetin	0-9	interleukin 6	Homo sapiens	49-53
31844103-0	2019	Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.	Quercetin	67-76	sirtuin 6	Homo sapiens	54-63
31844103-4	2019	To understand Sirt6 modulation by quercetin-based compounds, we analysed their binding and activity effects on Sirt6 and other Sirtuin isoforms and solved crystal structures of compound complexes with Sirt6 and Sirt2.	Quercetin	34-43	sirtuin 6	Homo sapiens	14-19
31844103-4	2019	To understand Sirt6 modulation by quercetin-based compounds, we analysed their binding and activity effects on Sirt6 and other Sirtuin isoforms and solved crystal structures of compound complexes with Sirt6 and Sirt2.	Quercetin	34-43	sirtuin 6	Homo sapiens	111-116
31844103-4	2019	To understand Sirt6 modulation by quercetin-based compounds, we analysed their binding and activity effects on Sirt6 and other Sirtuin isoforms and solved crystal structures of compound complexes with Sirt6 and Sirt2.	Quercetin	34-43	sirtuin 6	Homo sapiens	111-116
31844103-4	2019	To understand Sirt6 modulation by quercetin-based compounds, we analysed their binding and activity effects on Sirt6 and other Sirtuin isoforms and solved crystal structures of compound complexes with Sirt6 and Sirt2.	Quercetin	34-43	sirtuin 2	Homo sapiens	211-216
31844103-5	2019	We find that quercetin activates Sirt6 via the isoform-specific binding site for pyrrolo[1,2-a]quinoxalines.	Quercetin	13-22	sirtuin 6	Homo sapiens	33-38
31610186-5	2019	Quercetin caused further increase in LPS-induced IL-6 and IL-8 levels.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
31844103-8	2019	Furthermore, we find that quercetin derivatives that inhibit rather than activate Sirt6 exploit the same general Sirt6 binding site as the activators, identifying it as a versatile allosteric site for Sirt6 modulation.	Quercetin	26-35	sirtuin 6	Homo sapiens	82-87
31122072-7	2019	The expression levels of Keap1/Nrf2/ARE in RPE cells were measured by western blot after pretreatment of Quercetin followed by CSE treatment.	Quercetin	105-114	kelch like ECH associated protein 1	Homo sapiens	25-30
31844103-8	2019	Furthermore, we find that quercetin derivatives that inhibit rather than activate Sirt6 exploit the same general Sirt6 binding site as the activators, identifying it as a versatile allosteric site for Sirt6 modulation.	Quercetin	26-35	sirtuin 6	Homo sapiens	113-118
31844103-8	2019	Furthermore, we find that quercetin derivatives that inhibit rather than activate Sirt6 exploit the same general Sirt6 binding site as the activators, identifying it as a versatile allosteric site for Sirt6 modulation.	Quercetin	26-35	sirtuin 6	Homo sapiens	113-118
31844103-9	2019	Our results thus provide a structural basis for Sirtuin effects of quercetin-related compounds and helpful insights for Sirt6-targeted drug development.	Quercetin	67-76	sirtuin 6	Homo sapiens	120-125
31697283-4	2019	Under the optimal conditions, the decreased fluorescence of Ni-CNFWs showed a good linear relationship with the concentration of Qut ranging from 0.5 to 300.0 muM, and the limit of detection was 0.137 muM (3sigma/k).	Quercetin	129-132	latexin	Homo sapiens	159-162
31697283-4	2019	Under the optimal conditions, the decreased fluorescence of Ni-CNFWs showed a good linear relationship with the concentration of Qut ranging from 0.5 to 300.0 muM, and the limit of detection was 0.137 muM (3sigma/k).	Quercetin	129-132	latexin	Homo sapiens	201-204
31781748-0	2019	Quercetin improves endothelial insulin sensitivity in obese mice by inhibiting Drp1 phosphorylation at serine 616 and mitochondrial fragmentation.	Quercetin	0-9	dynamin 1-like	Mus musculus	79-83
31781748-5	2019	In addition, western blot analysis showed that quercetin treatment suppressed the levels of dynamin-related protein 1 (Drp1) and phosphorylation at serine 616 in endothelial cells of obese mice.	Quercetin	47-56	dynamin 1-like	Mus musculus	92-117
31781748-5	2019	In addition, western blot analysis showed that quercetin treatment suppressed the levels of dynamin-related protein 1 (Drp1) and phosphorylation at serine 616 in endothelial cells of obese mice.	Quercetin	47-56	dynamin 1-like	Mus musculus	119-123
31781748-6	2019	Mechanistically, quercetin specifically suppressed Drp1 phosphorylation at serine 616, whereas it showed little effects on the Drp1 level and its phosphorylation at serine 637 in cultured endothelial cells under oxidative stress.	Quercetin	17-26	dynamin 1-like	Mus musculus	51-55
31781748-7	2019	Furthermore, our results also showed that quercetin suppressed Drp1 phosphorylation at serine 616 by inhibiting PKCdelta as revealed by western blot analysis.	Quercetin	42-51	dynamin 1-like	Mus musculus	63-67
31781748-7	2019	Furthermore, our results also showed that quercetin suppressed Drp1 phosphorylation at serine 616 by inhibiting PKCdelta as revealed by western blot analysis.	Quercetin	42-51	protein kinase C, delta	Mus musculus	112-120
31781748-8	2019	Knockdown of PKCdelta with siRNA alleviated the protective effects of quercetin on endothelial-mitochondrial dynamics and insulin sensitivity.	Quercetin	70-79	protein kinase C, delta	Mus musculus	13-21
31781748-9	2019	These results suggest that chronic oral treatment with quercetin exerts endothelial protective effects through inhibition of PKCdelta and the resultant mitochondrial fragmentation.	Quercetin	55-64	protein kinase C, delta	Mus musculus	125-133
31822735-4	2019	Fluorescence binding and isothermal titration calorimetric measurements suggested that quercetin and capsaicin bind to SphK1 with an excellent affinity, and significantly inhibits its activity with an admirable IC50 values.	Quercetin	87-96	sphingosine kinase 1	Homo sapiens	119-124
31822735-7	2019	Quercetin forms a stable complex with SphK1 without inducing any significant conformational changes in the protein structure.	Quercetin	0-9	sphingosine kinase 1	Homo sapiens	38-43
31822735-8	2019	In conclusion, we infer that quercetin and capsaicin provide a chemical scaffold to develop potent and selective inhibitors of SphK1 after required modifications for the clinical management of cancer.	Quercetin	29-38	sphingosine kinase 1	Homo sapiens	127-132
31816893-0	2019	Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells.	Quercetin	0-9	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	70-74
31816893-1	2019	OBJECTIVE: To investigate the process by which quercetin suppresses atherosclerosis by upregulating MST1-mediated autophagy in RAW264.7 macrophages.	Quercetin	47-56	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	100-104
31816893-10	2019	Furthermore, the expression of LC3-II/I and Beclin1 were increased, which was consistent with the ability of quercetin to promote autophagy.	Quercetin	109-118	beclin 1, autophagy related	Mus musculus	44-51
31816893-11	2019	Ox-LDL also increased the expression of MST1, and this increase was blocked by quercetin, which provided a potential mechanism by which quercetin may protect foam cells against age-related detrimental effects.	Quercetin	79-88	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	40-44
31816893-11	2019	Ox-LDL also increased the expression of MST1, and this increase was blocked by quercetin, which provided a potential mechanism by which quercetin may protect foam cells against age-related detrimental effects.	Quercetin	136-145	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	40-44
31307244-0	2019	Quercetin supports cell viability and inhibits apoptosis in cardiocytes by down-regulating miR-199a.	Quercetin	0-9	microRNA 199a-2	Rattus norvegicus	91-99
31307244-9	2019	We found quercetin mitigated hypoxia-caused viability reduction and apoptosis with restoring apoptosis-associated protein and rescuing phosphorylation of AMPK.	Quercetin	9-18	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	154-158
31307244-10	2019	Quercetin flattened hypoxia-evoked overexpression of miR-199a.	Quercetin	0-9	microRNA 199a-2	Rattus norvegicus	53-61
31307244-11	2019	miR-199a abrogated the protective effects of quercetin against hypoxia-elicited damages.	Quercetin	45-54	microRNA 199a-2	Rattus norvegicus	0-8
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	322-331	microRNA 199a-2	Rattus norvegicus	109-117
31122072-7	2019	The expression levels of Keap1/Nrf2/ARE in RPE cells were measured by western blot after pretreatment of Quercetin followed by CSE treatment.	Quercetin	105-114	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
31307244-12	2019	Quercetin elevated sirt1 which was repressed by hypoxia, while this effect was slight in miR-199a-overexpressed cells.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	19-24
31307244-14	2019	Further, quercetin facilitated the phosphorylation of AMPK by up-regulating sirt1.	Quercetin	9-18	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	54-58
31122072-10	2019	Furthermore, Quercetin exerts protective effects via activation Keap1/Nrf2/ARE pathway in CSE treated RPE cells.	Quercetin	13-22	kelch like ECH associated protein 1	Homo sapiens	64-69
31307244-14	2019	Further, quercetin facilitated the phosphorylation of AMPK by up-regulating sirt1.	Quercetin	9-18	sirtuin 1	Rattus norvegicus	76-81
31122072-10	2019	Furthermore, Quercetin exerts protective effects via activation Keap1/Nrf2/ARE pathway in CSE treated RPE cells.	Quercetin	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
31307244-15	2019	Collectively, quercetin participated in repressing miR-199a which negatively modulated sirt1.	Quercetin	14-23	microRNA 199a-2	Rattus norvegicus	51-59
31307244-15	2019	Collectively, quercetin participated in repressing miR-199a which negatively modulated sirt1.	Quercetin	14-23	sirtuin 1	Rattus norvegicus	87-92
31070087-3	2019	The present study aimed to use uridine diphosphate glycosyltransferase 88A1 (UGT88A1) from Arabidopsis thaliana to achieve the enzymatic synthesis of quercetin-4"-O-glucoside from quercetin.	Quercetin	150-159	UDP-glucosyl transferase 88A1	Arabidopsis thaliana	77-84
31307244-16	2019	Mechanically, through activating AMPK, quercetin protected cardiomyocytes cells against hypoxia-caused insults.	Quercetin	39-48	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	33-37
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	11-20	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	74-78
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	11-20	microRNA 199a-2	Rattus norvegicus	109-117
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	11-20	sirtuin 1	Rattus norvegicus	205-210
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	11-20	microRNA 199a-2	Rattus norvegicus	231-239
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	11-20	microRNA 199a-2	Rattus norvegicus	231-239
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	11-20	sirtuin 1	Rattus norvegicus	278-283
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	11-20	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	285-289
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	136-145	microRNA 199a-2	Rattus norvegicus	109-117
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	136-145	sirtuin 1	Rattus norvegicus	205-210
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	136-145	microRNA 199a-2	Rattus norvegicus	231-239
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	136-145	microRNA 199a-2	Rattus norvegicus	231-239
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	136-145	sirtuin 1	Rattus norvegicus	278-283
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	136-145	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	285-289
31307244-17	2019	Highlights Quercetin ameliorates hypoxia-evoked apoptosis and blockage of AMPK phosphorylation; The elevated miR-199a level is eased by quercetin, which might be a protective mechanism; Quercetin restores sirt1 level by repressing miR-199a expression; By mediating miR-199a and sirt1, AMPK phosphorylation is fortified by quercetin.	Quercetin	186-195	microRNA 199a-2	Rattus norvegicus	109-117
31070087-6	2019	One mutant, V18R, of UGT88A1 was obtained by site-directed mutation and showed a greater affinity (Km 0.20 mM) and twice the enzyme activity (552.3 mU/mg) towards quercetin compared with the wild-type enzyme (0.36 mM and 227.6 mU/mg, respectively).	Quercetin	163-172	UDP-glucosyl transferase 88A1	Arabidopsis thaliana	21-28
31070087-7	2019	The possible reason could be attributed to the distance change between the 18th amino-acid residue of UGT88A1 and the substrate quercetin, as deduced by molecular simulation.	Quercetin	128-137	UDP-glucosyl transferase 88A1	Arabidopsis thaliana	102-109
31378931-10	2019	Furthermore, docking simulations showed that catalpol efficiently oriented itself in the active site of SIRT1, indicating a higher total binding affinity score than that of other SIRT1 activators, such as resveratrol, SRT2104, and quercetin.	Quercetin	231-240	sirtuin 1	Mus musculus	104-109
29945484-0	2019	Quercetin inhibits LPS-induced macrophage migration by suppressing the iNOS/FAK/paxillin pathway and modulating the cytoskeleton.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	71-75
29945484-0	2019	Quercetin inhibits LPS-induced macrophage migration by suppressing the iNOS/FAK/paxillin pathway and modulating the cytoskeleton.	Quercetin	0-9	PTK2 protein tyrosine kinase 2	Mus musculus	76-79
29945484-0	2019	Quercetin inhibits LPS-induced macrophage migration by suppressing the iNOS/FAK/paxillin pathway and modulating the cytoskeleton.	Quercetin	0-9	paxillin	Mus musculus	80-88
29945484-3	2019	Quercetin significantly attenuated LPS-induced inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) production in RAW264.7 cells without affecting their viability.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	47-78
29945484-3	2019	Quercetin significantly attenuated LPS-induced inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) production in RAW264.7 cells without affecting their viability.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	80-84
29945484-7	2019	Moreover, quercetin inhibited the LPS-induced expression of p-FAK, p-paxillin, FAK, and paxillin as well as the cytoskeletal adapter proteins vinculin and Tensin-2.	Quercetin	10-19	PTK2 protein tyrosine kinase 2	Mus musculus	62-65
29945484-7	2019	Moreover, quercetin inhibited the LPS-induced expression of p-FAK, p-paxillin, FAK, and paxillin as well as the cytoskeletal adapter proteins vinculin and Tensin-2.	Quercetin	10-19	paxillin	Mus musculus	69-77
29945484-7	2019	Moreover, quercetin inhibited the LPS-induced expression of p-FAK, p-paxillin, FAK, and paxillin as well as the cytoskeletal adapter proteins vinculin and Tensin-2.	Quercetin	10-19	PTK2 protein tyrosine kinase 2	Mus musculus	79-82
29945484-7	2019	Moreover, quercetin inhibited the LPS-induced expression of p-FAK, p-paxillin, FAK, and paxillin as well as the cytoskeletal adapter proteins vinculin and Tensin-2.	Quercetin	10-19	paxillin	Mus musculus	88-96
29945484-7	2019	Moreover, quercetin inhibited the LPS-induced expression of p-FAK, p-paxillin, FAK, and paxillin as well as the cytoskeletal adapter proteins vinculin and Tensin-2.	Quercetin	10-19	vinculin	Mus musculus	142-150
29945484-7	2019	Moreover, quercetin inhibited the LPS-induced expression of p-FAK, p-paxillin, FAK, and paxillin as well as the cytoskeletal adapter proteins vinculin and Tensin-2.	Quercetin	10-19	tensin 2	Mus musculus	155-163
29945484-8	2019	Therefore, quercetin suppresses LPS-induced migration by inhibiting NO production, disrupting the F-actin cytoskeleton, and suppressing the FAK-paxillin pathway.	Quercetin	11-20	PTK2 protein tyrosine kinase 2	Mus musculus	140-143
29945484-8	2019	Therefore, quercetin suppresses LPS-induced migration by inhibiting NO production, disrupting the F-actin cytoskeleton, and suppressing the FAK-paxillin pathway.	Quercetin	11-20	paxillin	Mus musculus	144-152
31550528-6	2019	In vitro, quercetin remarkably suppressed the expression of matrix degrading proteases and inflammatory mediators, meantime promoted the production of cartilage anabolic factors in interleukin-1beta-induced (IL-1beta) rat chondrocytes.	Quercetin	10-19	interleukin 1 beta	Rattus norvegicus	181-198
31134338-7	2019	RESULTS: Quercetin significantly improved the immunohistochemical markers, mainly caspase and GFAP.	Quercetin	9-18	glial fibrillary acidic protein	Rattus norvegicus	94-98
32038944-14	2019	Results: Quercetin treatment for 12 weeks significantly reduced the levels of TC (P<0.001), TG (P<0.05), HDL (P<0.001), LDL (P<0.001), TNF-alpha (P<0.001) and IL-6 (P<0.001) compared with the model group.	Quercetin	9-18	tumor necrosis factor	Mus musculus	135-144
32038944-14	2019	Results: Quercetin treatment for 12 weeks significantly reduced the levels of TC (P<0.001), TG (P<0.05), HDL (P<0.001), LDL (P<0.001), TNF-alpha (P<0.001) and IL-6 (P<0.001) compared with the model group.	Quercetin	9-18	interleukin 6	Mus musculus	159-163
31550528-6	2019	In vitro, quercetin remarkably suppressed the expression of matrix degrading proteases and inflammatory mediators, meantime promoted the production of cartilage anabolic factors in interleukin-1beta-induced (IL-1beta) rat chondrocytes.	Quercetin	10-19	interleukin 1 alpha	Rattus norvegicus	208-216
31550528-7	2019	In addition, quercetin exhibited anti-apoptotic effects by decreasing intracellular reactive oxygen species (ROS), restoring mitochondrial membrane potential (MMP) and inhibiting the Caspase-3 pathway in apoptotic rat chondrocytes.	Quercetin	13-22	caspase 3	Rattus norvegicus	183-192
31550528-8	2019	Moreover, quercetin induced M2 polarization of macrophages and upregulated the expression of transforming growth factor beta (TGF-beta) and insulin-like growth factor (IGF), which in turn created a pro-chondrogenic microenvironment for chondrocytes and promoted the synthesis of glycosaminoglycan (GAG) in chondrocytes.	Quercetin	10-19	transforming growth factor alpha	Rattus norvegicus	126-134
31550528-8	2019	Moreover, quercetin induced M2 polarization of macrophages and upregulated the expression of transforming growth factor beta (TGF-beta) and insulin-like growth factor (IGF), which in turn created a pro-chondrogenic microenvironment for chondrocytes and promoted the synthesis of glycosaminoglycan (GAG) in chondrocytes.	Quercetin	10-19	insulin-like growth factor 1	Rattus norvegicus	140-172
31542428-5	2019	The effect of Que on the enzyme activities of acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS), the two enzymes of this pathway, was investigated directly in situ in permeabilized C6 cells.	Quercetin	14-17	acetyl-CoA carboxylase alpha	Homo sapiens	72-76
31542428-11	2019	Que also reduced the nuclear content of ChREBP, a glucose-induced transcription factor involved in the regulation of lipogenic genes.	Quercetin	0-3	MLX interacting protein like	Homo sapiens	40-46
31542428-5	2019	The effect of Que on the enzyme activities of acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS), the two enzymes of this pathway, was investigated directly in situ in permeabilized C6 cells.	Quercetin	14-17	fatty acid synthase	Homo sapiens	82-101
31542428-5	2019	The effect of Que on the enzyme activities of acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS), the two enzymes of this pathway, was investigated directly in situ in permeabilized C6 cells.	Quercetin	14-17	fatty acid synthase	Homo sapiens	103-106
31542428-6	2019	An inhibitory effect on ACC1 was observed after 4 h of 25 muM Que treatment, while FAS activity was not affected.	Quercetin	62-65	acetyl-CoA carboxylase alpha	Homo sapiens	24-28
31542428-9	2019	Expression studies demonstrated that Que acts at transcriptional level, by reducing the mRNA abundance and protein amount of ACC1 and HMGCR.	Quercetin	37-40	acetyl-CoA carboxylase alpha	Homo sapiens	125-129
31542428-9	2019	Expression studies demonstrated that Que acts at transcriptional level, by reducing the mRNA abundance and protein amount of ACC1 and HMGCR.	Quercetin	37-40	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	134-139
31542428-10	2019	Deepening the molecular mechanism, we found that Que decreased the expression of SREBP-1 and SREBP-2, transcriptional factors representing the main regulators of de novo fatty acid and cholesterol synthesis, respectively.	Quercetin	49-52	sterol regulatory element binding transcription factor 1	Homo sapiens	81-88
31542428-10	2019	Deepening the molecular mechanism, we found that Que decreased the expression of SREBP-1 and SREBP-2, transcriptional factors representing the main regulators of de novo fatty acid and cholesterol synthesis, respectively.	Quercetin	49-52	sterol regulatory element binding transcription factor 2	Homo sapiens	93-100
31290710-8	2019	IL-4 levels were decreased by Aroclor 1254 and tended to increase back to normal when quercetin was used.	Quercetin	86-95	interleukin 4	Rattus norvegicus	0-4
31509634-3	2019	This study examined the hypothesis that the oral administration of quercetin to low-density lipoprotein receptor-null (Ldlr-/- ) mice would improve gut health by altering the gut microbiota and controlling the levels of atherogenic lipid metabolites and proinflammatory mediators in the intestine and serum.	Quercetin	67-76	low density lipoprotein receptor	Mus musculus	80-112
31509634-3	2019	This study examined the hypothesis that the oral administration of quercetin to low-density lipoprotein receptor-null (Ldlr-/- ) mice would improve gut health by altering the gut microbiota and controlling the levels of atherogenic lipid metabolites and proinflammatory mediators in the intestine and serum.	Quercetin	67-76	low density lipoprotein receptor	Mus musculus	119-123
31509634-6	2019	Reduced malondialdehyde and increased interleukin 6 levels further indicated the protective effect of quercetin against immune/inflammatory responses and oxidative stress.	Quercetin	102-111	interleukin 6	Mus musculus	38-51
31812985-11	2019	In contrast, we found that Fkbp5 expression is exclusively modulated by quercetin.	Quercetin	72-81	FKBP prolyl isomerase 5	Homo sapiens	27-32
31290710-9	2019	The results indicated that quercetin imparted a protective effect against Aroclor 1254-induced toxicity in pregnant rats, in part, by modulating levels of important pro-inflammatory cytokines and reducing induced CYP1A1 and CYP2B1 expression.	Quercetin	27-36	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	213-219
31290710-9	2019	The results indicated that quercetin imparted a protective effect against Aroclor 1254-induced toxicity in pregnant rats, in part, by modulating levels of important pro-inflammatory cytokines and reducing induced CYP1A1 and CYP2B1 expression.	Quercetin	27-36	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	224-230
31593704-1	2019	AIMS: To investigate the effect of 7-O-geranylquercetin (GQ), a derivative of quercetin (Q), on reversing drug resistance in breast cancer MCF-7/ADR cells and reveal the mechanisms related to P-glycoprotein (P-gp).	Quercetin	46-55	ATP binding cassette subfamily B member 1	Homo sapiens	192-206
31393601-5	2019	RESULTS: Epicatechin gallate (ECG), epigallocatechin gallate (EGCG), quercetin (QUER), and myricetin (MYR) caused a significant decrease in plasmin activity by 60, 86, 65, and 90%, respectively.	Quercetin	69-78	plasminogen	Homo sapiens	140-147
31393601-5	2019	RESULTS: Epicatechin gallate (ECG), epigallocatechin gallate (EGCG), quercetin (QUER), and myricetin (MYR) caused a significant decrease in plasmin activity by 60, 86, 65, and 90%, respectively.	Quercetin	80-84	plasminogen	Homo sapiens	140-147
31593704-11	2019	Molecular modeling showed that GQ matched with P-gp better than Q.	Quercetin	32-33	ATP binding cassette subfamily B member 1	Homo sapiens	47-51
31775265-6	2019	The results showed that the improvement of the oxidative stress resistance of C. elegans induced by quercetin could be explained, at least in part, by the modulation of the insulin signaling pathway, involving genes age-1, akt-1, akt-2, daf-18, sgk-1, daf-2, and skn-1.	Quercetin	100-109	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	216-221
31452288-6	2019	Additionally, quercetin restored superoxide dismutase, catalase, and glutathione content in livers.	Quercetin	14-23	catalase	Mus musculus	55-63
31452288-7	2019	Not only that, quercetin markedly attenuated T2DM-induced production of interleukin 1 beta, interleukin 6, and TNF-alpha.	Quercetin	15-24	interleukin 1 beta	Mus musculus	72-90
31452288-7	2019	Not only that, quercetin markedly attenuated T2DM-induced production of interleukin 1 beta, interleukin 6, and TNF-alpha.	Quercetin	15-24	interleukin 6	Mus musculus	92-105
31452288-7	2019	Not only that, quercetin markedly attenuated T2DM-induced production of interleukin 1 beta, interleukin 6, and TNF-alpha.	Quercetin	15-24	tumor necrosis factor	Mus musculus	111-120
31775265-6	2019	The results showed that the improvement of the oxidative stress resistance of C. elegans induced by quercetin could be explained, at least in part, by the modulation of the insulin signaling pathway, involving genes age-1, akt-1, akt-2, daf-18, sgk-1, daf-2, and skn-1.	Quercetin	100-109	Serine/threonine-protein kinase akt-1	Caenorhabditis elegans	223-228
31775265-6	2019	The results showed that the improvement of the oxidative stress resistance of C. elegans induced by quercetin could be explained, at least in part, by the modulation of the insulin signaling pathway, involving genes age-1, akt-1, akt-2, daf-18, sgk-1, daf-2, and skn-1.	Quercetin	100-109	Serine/threonine-protein kinase akt-2	Caenorhabditis elegans	230-235
31775265-6	2019	The results showed that the improvement of the oxidative stress resistance of C. elegans induced by quercetin could be explained, at least in part, by the modulation of the insulin signaling pathway, involving genes age-1, akt-1, akt-2, daf-18, sgk-1, daf-2, and skn-1.	Quercetin	100-109	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18	Caenorhabditis elegans	237-243
31775265-6	2019	The results showed that the improvement of the oxidative stress resistance of C. elegans induced by quercetin could be explained, at least in part, by the modulation of the insulin signaling pathway, involving genes age-1, akt-1, akt-2, daf-18, sgk-1, daf-2, and skn-1.	Quercetin	100-109	Serine/threonine-protein kinase sgk-1	Caenorhabditis elegans	245-250
31775265-6	2019	The results showed that the improvement of the oxidative stress resistance of C. elegans induced by quercetin could be explained, at least in part, by the modulation of the insulin signaling pathway, involving genes age-1, akt-1, akt-2, daf-18, sgk-1, daf-2, and skn-1.	Quercetin	100-109	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	252-257
31775265-6	2019	The results showed that the improvement of the oxidative stress resistance of C. elegans induced by quercetin could be explained, at least in part, by the modulation of the insulin signaling pathway, involving genes age-1, akt-1, akt-2, daf-18, sgk-1, daf-2, and skn-1.	Quercetin	100-109	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	263-268
31775265-8	2019	Moreover, quercetin was also able to increase expression of hsp-16.2 in aged worms.	Quercetin	10-19	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	60-68
31644887-6	2019	In addition, the activation of ERK/Nrf2 signaling pathway was critical to the upregulation of HMOX1 induced by quercetin.	Quercetin	111-120	mitogen-activated protein kinase 1	Homo sapiens	31-34
31827551-8	2019	The active compounds of acacetin, kaempferol, luteolin, and quercetin showed a good binding affinity towards TNF (C-score >= 4).	Quercetin	60-69	tumor necrosis factor-like	Rattus norvegicus	109-112
31754803-10	2019	After embedding of quercetin-copper(II) complex as intercalator and electron donor, the concentrations of Pb(II) were determined by the changes of photocurrents.	Quercetin	19-28	submaxillary gland androgen regulated protein 3B	Homo sapiens	106-112
31644887-6	2019	In addition, the activation of ERK/Nrf2 signaling pathway was critical to the upregulation of HMOX1 induced by quercetin.	Quercetin	111-120	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
31644887-0	2019	Quercetin, but not rutin, attenuated hydrogen peroxide-induced cell damage via heme oxygenase-1 induction in endothelial cells.	Quercetin	0-9	heme oxygenase 1	Homo sapiens	79-95
31644887-5	2019	It was found that quercetin upregulated HMOX1 expression to protect endothelial cells against oxidative stress, and the protective effects of quercetin on H2O2-induced endothelial cell damage (such as loss of cell viability and reduction of nitric oxide) could be abolished by the specific small-interfering RNA against HMOX1 expression or HMOX1 activity inhibitor.	Quercetin	18-27	heme oxygenase 1	Homo sapiens	40-45
31644887-6	2019	In addition, the activation of ERK/Nrf2 signaling pathway was critical to the upregulation of HMOX1 induced by quercetin.	Quercetin	111-120	heme oxygenase 1	Homo sapiens	94-99
31644887-5	2019	It was found that quercetin upregulated HMOX1 expression to protect endothelial cells against oxidative stress, and the protective effects of quercetin on H2O2-induced endothelial cell damage (such as loss of cell viability and reduction of nitric oxide) could be abolished by the specific small-interfering RNA against HMOX1 expression or HMOX1 activity inhibitor.	Quercetin	18-27	heme oxygenase 1	Homo sapiens	320-325
31644887-5	2019	It was found that quercetin upregulated HMOX1 expression to protect endothelial cells against oxidative stress, and the protective effects of quercetin on H2O2-induced endothelial cell damage (such as loss of cell viability and reduction of nitric oxide) could be abolished by the specific small-interfering RNA against HMOX1 expression or HMOX1 activity inhibitor.	Quercetin	18-27	heme oxygenase 1	Homo sapiens	320-325
31731716-0	2019	Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling.	Quercetin	32-41	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	Danio rerio	116-119
31731716-0	2019	Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling.	Quercetin	32-41	signal transducer and activator of transcription 3 (acute-phase response factor)	Danio rerio	120-125
31644887-8	2019	Therefore, quercetin could attenuate oxidative stress-induced endothelial cell damage at least partly through ERK/Nrf2/HMOX1 pathway.	Quercetin	11-20	mitogen-activated protein kinase 1	Homo sapiens	110-113
31731716-4	2019	In this study, we found that S100A7 was highly expressed in cancer cells and could be reduced by luteolin (Lu) and quercetin (Qu) through Src/Stat3 signaling.	Quercetin	115-124	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	Danio rerio	138-141
31731716-4	2019	In this study, we found that S100A7 was highly expressed in cancer cells and could be reduced by luteolin (Lu) and quercetin (Qu) through Src/Stat3 signaling.	Quercetin	115-124	signal transducer and activator of transcription 3 (acute-phase response factor)	Danio rerio	142-147
31644887-8	2019	Therefore, quercetin could attenuate oxidative stress-induced endothelial cell damage at least partly through ERK/Nrf2/HMOX1 pathway.	Quercetin	11-20	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
31731716-4	2019	In this study, we found that S100A7 was highly expressed in cancer cells and could be reduced by luteolin (Lu) and quercetin (Qu) through Src/Stat3 signaling.	Quercetin	126-128	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	Danio rerio	138-141
31644887-8	2019	Therefore, quercetin could attenuate oxidative stress-induced endothelial cell damage at least partly through ERK/Nrf2/HMOX1 pathway.	Quercetin	11-20	heme oxygenase 1	Homo sapiens	119-124
31731716-4	2019	In this study, we found that S100A7 was highly expressed in cancer cells and could be reduced by luteolin (Lu) and quercetin (Qu) through Src/Stat3 signaling.	Quercetin	126-128	signal transducer and activator of transcription 3 (acute-phase response factor)	Danio rerio	142-147
31731716-6	2019	Flavonoids Lu and Qu reduce protein levels of p-Src, p-Stat3 and S100A7 in A431-III cells.	Quercetin	18-20	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	Danio rerio	48-51
31777425-7	2019	Plasma quercetin concentration was significantly higher in the HF3 group than in the HF1 group.	Quercetin	7-16	granzyme A	Mus musculus	85-88
31731716-6	2019	Flavonoids Lu and Qu reduce protein levels of p-Src, p-Stat3 and S100A7 in A431-III cells.	Quercetin	18-20	signal transducer and activator of transcription 3 (acute-phase response factor)	Danio rerio	55-60
31731716-13	2019	These results suggest that Lu and Qu may inhibit Src/Stat3/S100A7 signaling to reduce tumorigenesis of cancer cells.	Quercetin	34-36	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	Danio rerio	49-52
31731716-13	2019	These results suggest that Lu and Qu may inhibit Src/Stat3/S100A7 signaling to reduce tumorigenesis of cancer cells.	Quercetin	34-36	signal transducer and activator of transcription 3 (acute-phase response factor)	Danio rerio	53-58
31827702-7	2019	Cotreatment with the autophagy inhibitor (3-methyladenine, LY294002, or chloroquine) resulted in a significant enhancement of quercetin-induced BAK activation and subsequently the mitochondrial damage-mediated apoptosis pathway by augmenting the downregulation of BAG3 and MCL-1 levels in J/Neo cells.	Quercetin	126-135	BAG cochaperone 3	Homo sapiens	264-268
31827702-7	2019	Cotreatment with the autophagy inhibitor (3-methyladenine, LY294002, or chloroquine) resulted in a significant enhancement of quercetin-induced BAK activation and subsequently the mitochondrial damage-mediated apoptosis pathway by augmenting the downregulation of BAG3 and MCL-1 levels in J/Neo cells.	Quercetin	126-135	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	273-278
31699098-13	2019	Further, we revealed that quercetin could suppress macrophages/microglia polarized to M1 phenotype through inhibition of STAT1 and NF-kappaB pathway in vivo and in vitro, which contributes to the decreased necroptosis of OLs.	Quercetin	26-35	signal transducer and activator of transcription 1	Rattus norvegicus	121-126
31781321-0	2019	A Solid Dispersion of Quercetin Shows Enhanced Nrf2 Activation and Protective Effects against Oxidative Injury in a Mouse Model of Dry Age-Related Macular Degeneration.	Quercetin	22-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	47-51
31781321-0	2019	A Solid Dispersion of Quercetin Shows Enhanced Nrf2 Activation and Protective Effects against Oxidative Injury in a Mouse Model of Dry Age-Related Macular Degeneration.	Quercetin	22-31	renin binding protein	Mus musculus	135-138
32104488-0	2019	Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models.	Quercetin	72-81	ATP binding cassette subfamily C member 2	Rattus norvegicus	18-22
32104488-3	2019	In this study, we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2 (MRP2), another major efflux transporter.	Quercetin	96-105	ATP binding cassette subfamily C member 2	Rattus norvegicus	118-159
32104488-3	2019	In this study, we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2 (MRP2), another major efflux transporter.	Quercetin	96-105	ATP binding cassette subfamily C member 2	Rattus norvegicus	161-165
32104488-4	2019	MRP2-transfected MDCKII cells and LS174T cells were used to evaluate the potential inhibition and induction of MRP2 by quercetin in vitro.	Quercetin	119-128	ATP binding cassette subfamily C member 2	Homo sapiens	111-115
32104488-6	2019	Mrp2-mediated interaction potential was also evaluated by the pharmacokinetic study of phenolsulfonphthalein in rats after single or multiple doses of quercetin.	Quercetin	151-160	ATP binding cassette subfamily C member 2	Rattus norvegicus	0-4
32104488-8	2019	Quercetin inhibited the function of MRP2 at 10 microM and induced the mRNA expression of MRP2 at 50 microM in vitro.	Quercetin	0-9	ATP binding cassette subfamily C member 2	Rattus norvegicus	36-40
32104488-8	2019	Quercetin inhibited the function of MRP2 at 10 microM and induced the mRNA expression of MRP2 at 50 microM in vitro.	Quercetin	0-9	ATP binding cassette subfamily C member 2	Rattus norvegicus	89-93
32104488-9	2019	Additionally, at 100 mg/kg, quercetin markedly increased Mrp2 expression in the small intestine of rats.	Quercetin	28-37	ATP binding cassette subfamily C member 2	Rattus norvegicus	57-61
32104488-12	2019	The results suggested that although quercetin modulates the function and expression of MRP2 in vitro, it may have a low potential of Mrp2-mediated interaction and present negligible safety concerns related to the interaction.	Quercetin	36-45	ATP binding cassette subfamily C member 2	Rattus norvegicus	87-91
32104488-12	2019	The results suggested that although quercetin modulates the function and expression of MRP2 in vitro, it may have a low potential of Mrp2-mediated interaction and present negligible safety concerns related to the interaction.	Quercetin	36-45	ATP binding cassette subfamily C member 2	Rattus norvegicus	133-137
31827702-1	2019	A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL).	Quercetin	24-33	ATM serine/threonine kinase	Homo sapiens	76-79
31827702-1	2019	A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL).	Quercetin	24-33	choline kinase alpha	Homo sapiens	80-83
31827702-1	2019	A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL).	Quercetin	24-33	tumor protein p53	Homo sapiens	84-87
31827702-1	2019	A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL).	Quercetin	24-33	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	172-176
31827702-1	2019	A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL).	Quercetin	24-33	BCL2 like 1	Homo sapiens	249-255
31827702-4	2019	Both cytosolic and mitochondrial ROS levels were elevated in quercetin-treated J/Neo cells; however, the ROS elevations were almost completely abrogated in J/BCL-XL cells, suggesting the ROS elevations were downstream of BCL-XL-sensitive mitochondrial damage and dysfunction.	Quercetin	61-70	BCL2 like 1	Homo sapiens	158-164
31827702-4	2019	Both cytosolic and mitochondrial ROS levels were elevated in quercetin-treated J/Neo cells; however, the ROS elevations were almost completely abrogated in J/BCL-XL cells, suggesting the ROS elevations were downstream of BCL-XL-sensitive mitochondrial damage and dysfunction.	Quercetin	61-70	BCL2 like 1	Homo sapiens	221-227
31827702-5	2019	Wild-type A3, FADD-deficient I2.1, and caspase-8-deficient I9.2 Jurkat clones exhibited similar susceptibilities to the cytotoxicity of quercetin, excluding an involvement of extrinsic pathway in triggering the apoptosis.	Quercetin	136-145	caspase 8	Homo sapiens	39-48
31378953-5	2019	Moreover, the quercetins significantly induced detoxifying enzymes via the nuclear accumulation of the NF-E2-related factor 2 (Nrf2) and induction of antioxidant response element (ARE) gene.	Quercetin	14-24	NFE2 like bZIP transcription factor 2	Homo sapiens	103-125
31378953-5	2019	Moreover, the quercetins significantly induced detoxifying enzymes via the nuclear accumulation of the NF-E2-related factor 2 (Nrf2) and induction of antioxidant response element (ARE) gene.	Quercetin	14-24	NFE2 like bZIP transcription factor 2	Homo sapiens	127-131
31378953-9	2019	In the present study, quercetin and its glycosides was shown to alleviate oxidative stress, glutathione depletion, and pro-inflammatory cytokines in alcohol-induced HepG2 cells via the Nrf2/ARE antioxidant pathway.	Quercetin	22-31	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
31356770-3	2019	Quercetin is an abundant dietary flavonoid that selectively clears inhibiting PI3K/AKT and p53/p21/serpines and inducing apoptosis.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	83-86
31548332-9	2019	Pretreatment with quercetin, which increases SIRT-1 expression, normalized RV-induced IFN levels in COPD airway epithelial cells.	Quercetin	18-27	sirtuin 1	Homo sapiens	45-51
31548332-10	2019	Inhibition of SIRT-1 in quercetin-pretreated COPD cells abolished the normalizing effects of quercetin on RV-induced IFN expression in these cells, confirming that quercetin exerts its effect via SIRT-1.	Quercetin	24-33	sirtuin 1	Homo sapiens	14-20
31548332-10	2019	Inhibition of SIRT-1 in quercetin-pretreated COPD cells abolished the normalizing effects of quercetin on RV-induced IFN expression in these cells, confirming that quercetin exerts its effect via SIRT-1.	Quercetin	24-33	sirtuin 1	Homo sapiens	196-202
31548332-10	2019	Inhibition of SIRT-1 in quercetin-pretreated COPD cells abolished the normalizing effects of quercetin on RV-induced IFN expression in these cells, confirming that quercetin exerts its effect via SIRT-1.	Quercetin	93-102	sirtuin 1	Homo sapiens	14-20
31548332-10	2019	Inhibition of SIRT-1 in quercetin-pretreated COPD cells abolished the normalizing effects of quercetin on RV-induced IFN expression in these cells, confirming that quercetin exerts its effect via SIRT-1.	Quercetin	93-102	sirtuin 1	Homo sapiens	14-20
31614146-5	2019	This study was carried out to elucidate the antineoplastic effect of quercetin through regulating both Notch and Hh pathways, apoptosis, cell proliferation and CK2alpha activity.	Quercetin	69-78	notch receptor 1	Rattus norvegicus	103-108
31614146-5	2019	This study was carried out to elucidate the antineoplastic effect of quercetin through regulating both Notch and Hh pathways, apoptosis, cell proliferation and CK2alpha activity.	Quercetin	69-78	casein kinase 2 alpha 2	Homo sapiens	160-168
31614146-12	2019	KEY FINDINGS: Quercetin inhibited CK2alpha and downregulated mRNA and protein expression of Notch1 and Gli2.	Quercetin	14-23	casein kinase 2 alpha 2	Homo sapiens	34-42
31614146-12	2019	KEY FINDINGS: Quercetin inhibited CK2alpha and downregulated mRNA and protein expression of Notch1 and Gli2.	Quercetin	14-23	notch receptor 1	Rattus norvegicus	92-98
31614146-12	2019	KEY FINDINGS: Quercetin inhibited CK2alpha and downregulated mRNA and protein expression of Notch1 and Gli2.	Quercetin	14-23	GLI family zinc finger 2	Rattus norvegicus	103-107
31614146-13	2019	Quercetin also suppressed caspase-3 expression but not caspase-8.	Quercetin	0-9	caspase 3	Rattus norvegicus	26-35
31614146-14	2019	Quercetin elevated p53 expression whereas proliferative and cell cycle markers cyclin D1 and Ki-67 were downregulated.	Quercetin	0-9	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	19-22
31614146-18	2019	SIGNIFICANCE: We can conclude that in addition to its antioxidant power, quercetin blocked Notch, Hedgehog, regulated the apoptotic and proliferative pathways and inhibited CK2alpha in HCC.	Quercetin	73-82	notch receptor 1	Rattus norvegicus	91-96
31614146-18	2019	SIGNIFICANCE: We can conclude that in addition to its antioxidant power, quercetin blocked Notch, Hedgehog, regulated the apoptotic and proliferative pathways and inhibited CK2alpha in HCC.	Quercetin	73-82	casein kinase 2 alpha 2	Homo sapiens	173-181
31564569-9	2019	Curcumin, Quercetin and Withaferin A are known to inhibit multiple molecular pathways that are involved in RAGE signaling.	Quercetin	10-19	advanced glycosylation end-product specific receptor	Homo sapiens	107-111
31618777-8	2019	At lower doses, compounds like 2,2",4"-trihydroxychalcone acid, quercetin, and myricetin have been shown to effectively reduce beta-site amyloid precursor protein-cleaving enzyme 1 activity.	Quercetin	64-73	beta-secretase 1	Homo sapiens	127-180
31356770-3	2019	Quercetin is an abundant dietary flavonoid that selectively clears inhibiting PI3K/AKT and p53/p21/serpines and inducing apoptosis.	Quercetin	0-9	transformation related protein 53, pseudogene	Mus musculus	91-94
31356770-3	2019	Quercetin is an abundant dietary flavonoid that selectively clears inhibiting PI3K/AKT and p53/p21/serpines and inducing apoptosis.	Quercetin	0-9	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	95-98
31652815-5	2019	Treatment with quercetin suppressed UV-induced matrix metalloproteinase-1 (MMP-1) and cyclooxygenase-2 (COX-2) expression and prevented UV-mediated collagen degradation in human skin tissues.	Quercetin	15-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	104-109
31781635-14	2019	Besides, the ELISA results showed that TNF-alpha, IL-1beta, and IL-6 were reduced in LPS-stimulated RAW264.7 cells after interfering with quercetin and quercitrin.	Quercetin	138-147	tumor necrosis factor	Mus musculus	39-48
31781635-14	2019	Besides, the ELISA results showed that TNF-alpha, IL-1beta, and IL-6 were reduced in LPS-stimulated RAW264.7 cells after interfering with quercetin and quercitrin.	Quercetin	138-147	interleukin 1 beta	Mus musculus	50-58
31781635-14	2019	Besides, the ELISA results showed that TNF-alpha, IL-1beta, and IL-6 were reduced in LPS-stimulated RAW264.7 cells after interfering with quercetin and quercitrin.	Quercetin	138-147	interleukin 6	Mus musculus	64-68
31741663-8	2019	Between-group comparison using analysis of covariance analysis though showed that quercetin could significantly reduce ALT (P = 0.002), but there was an insignificant increase in SOD and TAC, and insignificant decrease in GPx, MDA, AST, and ALP (P > 0.05).	Quercetin	82-91	solute carrier family 17 member 5	Homo sapiens	232-235
31741663-8	2019	Between-group comparison using analysis of covariance analysis though showed that quercetin could significantly reduce ALT (P = 0.002), but there was an insignificant increase in SOD and TAC, and insignificant decrease in GPx, MDA, AST, and ALP (P > 0.05).	Quercetin	82-91	alkaline phosphatase, placental	Homo sapiens	241-244
31652815-0	2019	Quercetin Directly Targets JAK2 and PKCdelta and Prevents UV-Induced Photoaging in Human Skin.	Quercetin	0-9	Janus kinase 2	Homo sapiens	27-31
31652815-0	2019	Quercetin Directly Targets JAK2 and PKCdelta and Prevents UV-Induced Photoaging in Human Skin.	Quercetin	0-9	protein kinase C delta	Homo sapiens	36-44
31665932-6	2022	The treatment of DEN/2AAF-administered rats with quercetin and naringenin significantly prevented the elevations in serum levels of liver function indicators (ALT, AST, ALP, gamma-GT, total bilirubin and albumin) and liver tumor biomarkers including AFP, CEA and CA19.9.	Quercetin	49-58	alpha-fetoprotein	Rattus norvegicus	250-253
31665932-6	2022	The treatment of DEN/2AAF-administered rats with quercetin and naringenin significantly prevented the elevations in serum levels of liver function indicators (ALT, AST, ALP, gamma-GT, total bilirubin and albumin) and liver tumor biomarkers including AFP, CEA and CA19.9.	Quercetin	49-58	carcinoembryonic antigen gene family 4	Rattus norvegicus	255-258
31665932-9	2022	Furthermore, the lowered mRNA expression of liver IL-4, P53 and Bcl-2 in of DEN/2AAF-administered rats were significantly counteracted by treatment with quercetin and naringenin.	Quercetin	153-162	interleukin 4	Rattus norvegicus	50-54
31665932-9	2022	Furthermore, the lowered mRNA expression of liver IL-4, P53 and Bcl-2 in of DEN/2AAF-administered rats were significantly counteracted by treatment with quercetin and naringenin.	Quercetin	153-162	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	56-59
31665932-9	2022	Furthermore, the lowered mRNA expression of liver IL-4, P53 and Bcl-2 in of DEN/2AAF-administered rats were significantly counteracted by treatment with quercetin and naringenin.	Quercetin	153-162	BCL2, apoptosis regulator	Rattus norvegicus	64-69
31655554-5	2019	RESULTS: Here we provide evidence that the previously described tomato wound and pathogen-induced glycosyltransferase Twi1 displays in vitro activity toward the coumarins scopoletin, umbelliferone and esculetin, and the flavonoids quercetin and kaempferol, by uncovering a new role of this gene in plant glycosylation.	Quercetin	231-240	scopoletin glucosyltransferase	Solanum lycopersicum	118-122
31655554-9	2019	Twi1 glycosyltransferase showed to regulate quercetin and kaempferol levels in tomato plants, affecting plant resistance to viral infection.	Quercetin	44-53	scopoletin glucosyltransferase	Solanum lycopersicum	0-4
31653035-12	2019	Interestingly, the addition of ganoderic acid A (GAA) could produce similar bioactive effects like GLE in QCT-mediated antitumor activity.	Quercetin	106-109	alpha glucosidase	Homo sapiens	49-52
31653035-13	2019	The GAA addition in low concentrations synergistically reinforced QCT-induced apoptosis and EBV lytic reactivation.	Quercetin	66-69	alpha glucosidase	Homo sapiens	4-7
31652815-5	2019	Treatment with quercetin suppressed UV-induced matrix metalloproteinase-1 (MMP-1) and cyclooxygenase-2 (COX-2) expression and prevented UV-mediated collagen degradation in human skin tissues.	Quercetin	15-24	matrix metallopeptidase 1	Homo sapiens	47-73
31652815-5	2019	Treatment with quercetin suppressed UV-induced matrix metalloproteinase-1 (MMP-1) and cyclooxygenase-2 (COX-2) expression and prevented UV-mediated collagen degradation in human skin tissues.	Quercetin	15-24	matrix metallopeptidase 1	Homo sapiens	75-80
31652815-5	2019	Treatment with quercetin suppressed UV-induced matrix metalloproteinase-1 (MMP-1) and cyclooxygenase-2 (COX-2) expression and prevented UV-mediated collagen degradation in human skin tissues.	Quercetin	15-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-102
31652815-6	2019	Quercetin exerted potent inhibitory effects towards UV-induced activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) activity.	Quercetin	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-82
31652815-6	2019	Quercetin exerted potent inhibitory effects towards UV-induced activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) activity.	Quercetin	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-88
31652815-6	2019	Quercetin exerted potent inhibitory effects towards UV-induced activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) activity.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	94-116
31652815-6	2019	Quercetin exerted potent inhibitory effects towards UV-induced activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) activity.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	118-127
31652815-7	2019	Further examination of the upstream signaling pathways revealed that quercetin can attenuate UV-mediated phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N terminal kinases (JNK), protein kinase B (Akt), and signal transducer and activator of transcription 3 (STAT3).	Quercetin	69-78	mitogen-activated protein kinase 1	Homo sapiens	124-161
31652815-7	2019	Further examination of the upstream signaling pathways revealed that quercetin can attenuate UV-mediated phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N terminal kinases (JNK), protein kinase B (Akt), and signal transducer and activator of transcription 3 (STAT3).	Quercetin	69-78	mitogen-activated protein kinase 1	Homo sapiens	163-166
31652815-7	2019	Further examination of the upstream signaling pathways revealed that quercetin can attenuate UV-mediated phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N terminal kinases (JNK), protein kinase B (Akt), and signal transducer and activator of transcription 3 (STAT3).	Quercetin	69-78	mitogen-activated protein kinase 8	Homo sapiens	169-199
31652815-7	2019	Further examination of the upstream signaling pathways revealed that quercetin can attenuate UV-mediated phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N terminal kinases (JNK), protein kinase B (Akt), and signal transducer and activator of transcription 3 (STAT3).	Quercetin	69-78	protein tyrosine kinase 2 beta	Homo sapiens	201-217
31652815-7	2019	Further examination of the upstream signaling pathways revealed that quercetin can attenuate UV-mediated phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N terminal kinases (JNK), protein kinase B (Akt), and signal transducer and activator of transcription 3 (STAT3).	Quercetin	69-78	AKT serine/threonine kinase 1	Homo sapiens	219-222
31652815-7	2019	Further examination of the upstream signaling pathways revealed that quercetin can attenuate UV-mediated phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N terminal kinases (JNK), protein kinase B (Akt), and signal transducer and activator of transcription 3 (STAT3).	Quercetin	69-78	signal transducer and activator of transcription 3	Homo sapiens	229-279
31652632-3	2019	The SIL formulation is a dietary supplement that was designed leveraging the more bioavailable forms of ingredients with poor absorption, such as curcumin and quercetin.	Quercetin	159-168	STIL centriolar assembly protein	Homo sapiens	4-7
31652815-7	2019	Further examination of the upstream signaling pathways revealed that quercetin can attenuate UV-mediated phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N terminal kinases (JNK), protein kinase B (Akt), and signal transducer and activator of transcription 3 (STAT3).	Quercetin	69-78	signal transducer and activator of transcription 3	Homo sapiens	281-286
31652815-8	2019	Kinase assays using purified protein demonstrated that quercetin can directly inhibit protein kinase C delta (PKCdelta) and Janus kinase 2 (JAK2) kinase activity.	Quercetin	55-64	protein kinase C delta	Homo sapiens	86-108
31652815-8	2019	Kinase assays using purified protein demonstrated that quercetin can directly inhibit protein kinase C delta (PKCdelta) and Janus kinase 2 (JAK2) kinase activity.	Quercetin	55-64	protein kinase C delta	Homo sapiens	110-118
31652815-8	2019	Kinase assays using purified protein demonstrated that quercetin can directly inhibit protein kinase C delta (PKCdelta) and Janus kinase 2 (JAK2) kinase activity.	Quercetin	55-64	Janus kinase 2	Homo sapiens	124-138
31652815-8	2019	Kinase assays using purified protein demonstrated that quercetin can directly inhibit protein kinase C delta (PKCdelta) and Janus kinase 2 (JAK2) kinase activity.	Quercetin	55-64	Janus kinase 2	Homo sapiens	140-144
31652815-9	2019	Quercetin was observed to bind to PKCdelta and JAK2 in pull-down assays.	Quercetin	0-9	protein kinase C delta	Homo sapiens	34-42
31652815-9	2019	Quercetin was observed to bind to PKCdelta and JAK2 in pull-down assays.	Quercetin	0-9	Janus kinase 2	Homo sapiens	47-51
31652815-10	2019	These findings suggest that quercetin can directly target PKCdelta and JAK2 in the skin to elicit protective effects against UV-mediated skin aging and inflammation.	Quercetin	28-37	protein kinase C delta	Homo sapiens	58-66
31652815-10	2019	These findings suggest that quercetin can directly target PKCdelta and JAK2 in the skin to elicit protective effects against UV-mediated skin aging and inflammation.	Quercetin	28-37	Janus kinase 2	Homo sapiens	71-75
31344364-2	2019	The aim of our study was to examine the direct effects of quercetin on basic ovarian cell functions and their response to follicle-stimulating hormone (FSH) and insulin-like growth factor I (IGF-I), known hormonal stimulators of reproduction.	Quercetin	58-67	insulin like growth factor 1	Homo sapiens	161-189
31344364-2	2019	The aim of our study was to examine the direct effects of quercetin on basic ovarian cell functions and their response to follicle-stimulating hormone (FSH) and insulin-like growth factor I (IGF-I), known hormonal stimulators of reproduction.	Quercetin	58-67	insulin like growth factor 1	Homo sapiens	191-196
31344364-5	2019	Addition of quercetin reduced the accumulation of PCNA and cyclin B1, as well as their transcript levels, promoted the accumulation of BAX, decreased the release of P4 and L, and increased the release of T in cultured granulosa cells.	Quercetin	12-21	proliferating cell nuclear antigen	Homo sapiens	50-54
31344364-5	2019	Addition of quercetin reduced the accumulation of PCNA and cyclin B1, as well as their transcript levels, promoted the accumulation of BAX, decreased the release of P4 and L, and increased the release of T in cultured granulosa cells.	Quercetin	12-21	cyclin B1	Homo sapiens	59-68
31344364-5	2019	Addition of quercetin reduced the accumulation of PCNA and cyclin B1, as well as their transcript levels, promoted the accumulation of BAX, decreased the release of P4 and L, and increased the release of T in cultured granulosa cells.	Quercetin	12-21	BCL2 associated X, apoptosis regulator	Homo sapiens	135-138
31348906-0	2019	Antitumor and apoptotic effects of quercetin on human melanoma cells involving JNK/P38 MAPK signaling activation.	Quercetin	35-44	mitogen-activated protein kinase 8	Homo sapiens	79-82
31348906-9	2019	Quercetin increased the expression of Bax, phospho-JNK, phospho-p38 and phospho-ERK1/2, cleaved poly-ADP ribose polymerase and decreased Bcl-2 in a concentration-dependent manner.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	38-41
31348906-9	2019	Quercetin increased the expression of Bax, phospho-JNK, phospho-p38 and phospho-ERK1/2, cleaved poly-ADP ribose polymerase and decreased Bcl-2 in a concentration-dependent manner.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	51-54
31348906-9	2019	Quercetin increased the expression of Bax, phospho-JNK, phospho-p38 and phospho-ERK1/2, cleaved poly-ADP ribose polymerase and decreased Bcl-2 in a concentration-dependent manner.	Quercetin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	96-122
31348906-9	2019	Quercetin increased the expression of Bax, phospho-JNK, phospho-p38 and phospho-ERK1/2, cleaved poly-ADP ribose polymerase and decreased Bcl-2 in a concentration-dependent manner.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	137-142
31348906-12	2019	Immunohistochemistry staining revealed that the level of phosphor-JNK and phosphor-p38 increased in the quercetin-treated mice.	Quercetin	104-113	mitogen-activated protein kinase 8	Mus musculus	66-69
31407037-5	2019	In the second system, flavonol 7-O-rhamnosyltransferase (AtUGT89C1) from A. thaliana was used to transfer rhamnose from UDP-beta-L-rhamnose to quercetin, in which AtSUS1 along with UDP-beta-L-rhamnose synthase (AtRHM1), also from A. thaliana, were used to produce UDP-beta-L-rhamnose from the same starter sucrose.	Quercetin	143-152	sucrose synthase 1	Arabidopsis thaliana	163-169
31407037-5	2019	In the second system, flavonol 7-O-rhamnosyltransferase (AtUGT89C1) from A. thaliana was used to transfer rhamnose from UDP-beta-L-rhamnose to quercetin, in which AtSUS1 along with UDP-beta-L-rhamnose synthase (AtRHM1), also from A. thaliana, were used to produce UDP-beta-L-rhamnose from the same starter sucrose.	Quercetin	143-152	rhamnose biosynthesis 1	Arabidopsis thaliana	211-217
31365139-15	2019	This is the first report where quercetin was shown to modulate the immune response to arthritis via attenuation of the purinergic system (E-NTPDase and E-ADA activities) and the levels of IFN-gamma and IL-4.	Quercetin	31-40	interleukin 4	Rattus norvegicus	202-206
31800737-0	2019	QUERCETIN SUPPLEMENTATION PREVENTS CHANGES IN THE SEROTONIN AND CASPASE-3 IMMUNOREACTIVE CELLS OF THE JEJUNUM OF DIABETIC RATS.	Quercetin	0-9	caspase 3	Rattus norvegicus	64-73
31555357-0	2019	Quercetin has a protective effect on atherosclerosis via enhancement of autophagy in ApoE-/- mice.	Quercetin	0-9	apolipoprotein E	Mus musculus	85-89
31555357-11	2019	The inhibition of AS by QUE may be associated with the enhancement of autophagy and upregulation of P21 and P53 expression.	Quercetin	24-27	transformation related protein 53, pseudogene	Mus musculus	108-111
31529802-0	2019	Quercetin Mitigates Hepatic Insulin Resistance in Rats with Bile Duct Ligation Through Modulation of the STAT3/SOCS3/IRS1 Signaling Pathway.	Quercetin	0-9	signal transducer and activator of transcription 3	Rattus norvegicus	105-110
31295065-3	2019	As quercetin activates PGC-1alpha through Sirtuin-1, an NAD+-dependent deacetylase, the depleted NAD+ in dystrophic skeletal muscle may limit quercetin efficacy, hence, supplementation with the NAD+ donor, nicotinamide riboside (NR), may facilitate quercetin efficacy.	Quercetin	3-12	PPARG coactivator 1 alpha	Homo sapiens	23-33
31295065-3	2019	As quercetin activates PGC-1alpha through Sirtuin-1, an NAD+-dependent deacetylase, the depleted NAD+ in dystrophic skeletal muscle may limit quercetin efficacy, hence, supplementation with the NAD+ donor, nicotinamide riboside (NR), may facilitate quercetin efficacy.	Quercetin	3-12	sirtuin 1	Homo sapiens	42-51
31295065-3	2019	As quercetin activates PGC-1alpha through Sirtuin-1, an NAD+-dependent deacetylase, the depleted NAD+ in dystrophic skeletal muscle may limit quercetin efficacy, hence, supplementation with the NAD+ donor, nicotinamide riboside (NR), may facilitate quercetin efficacy.	Quercetin	142-151	PPARG coactivator 1 alpha	Homo sapiens	23-33
31295065-3	2019	As quercetin activates PGC-1alpha through Sirtuin-1, an NAD+-dependent deacetylase, the depleted NAD+ in dystrophic skeletal muscle may limit quercetin efficacy, hence, supplementation with the NAD+ donor, nicotinamide riboside (NR), may facilitate quercetin efficacy.	Quercetin	142-151	PPARG coactivator 1 alpha	Homo sapiens	23-33
31369203-4	2019	In this work we studied the anti-angiogenic effect of quercetin (Q) and some of its derivates in human microvascular endothelial cells, as a blood retinal barrier model, after stimulation with VEGF-A.	Quercetin	54-63	vascular endothelial growth factor A	Homo sapiens	193-199
31529802-7	2019	The antidiabetic impact of quercetin was associated with reduction in mRNA and expression of protein in STAT3 and SOCS3, along with an increase in IRS1.	Quercetin	27-36	signal transducer and activator of transcription 3	Rattus norvegicus	104-109
31529802-7	2019	The antidiabetic impact of quercetin was associated with reduction in mRNA and expression of protein in STAT3 and SOCS3, along with an increase in IRS1.	Quercetin	27-36	suppressor of cytokine signaling 3	Rattus norvegicus	114-119
31529802-0	2019	Quercetin Mitigates Hepatic Insulin Resistance in Rats with Bile Duct Ligation Through Modulation of the STAT3/SOCS3/IRS1 Signaling Pathway.	Quercetin	0-9	suppressor of cytokine signaling 3	Rattus norvegicus	111-116
31529802-7	2019	The antidiabetic impact of quercetin was associated with reduction in mRNA and expression of protein in STAT3 and SOCS3, along with an increase in IRS1.	Quercetin	27-36	insulin receptor substrate 1	Rattus norvegicus	147-151
31529802-0	2019	Quercetin Mitigates Hepatic Insulin Resistance in Rats with Bile Duct Ligation Through Modulation of the STAT3/SOCS3/IRS1 Signaling Pathway.	Quercetin	0-9	insulin receptor substrate 1	Rattus norvegicus	117-121
31529802-8	2019	The antifibrotic effect of quercetin was also determined by downregulation of mRNA or the levels of protein expression of Rac1-GTP, Rac1, HIF-1alpha, NOX1, and Sp1, along with ERK1.	Quercetin	27-36	Rac family small GTPase 1	Rattus norvegicus	122-126
31529802-8	2019	The antifibrotic effect of quercetin was also determined by downregulation of mRNA or the levels of protein expression of Rac1-GTP, Rac1, HIF-1alpha, NOX1, and Sp1, along with ERK1.	Quercetin	27-36	Rac family small GTPase 1	Rattus norvegicus	132-136
31377559-9	2019	A similar abolition of nicotine effects was seen after HSP70 inhibition by quercetin.	Quercetin	75-84	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	55-60
31529802-8	2019	The antifibrotic effect of quercetin was also determined by downregulation of mRNA or the levels of protein expression of Rac1-GTP, Rac1, HIF-1alpha, NOX1, and Sp1, along with ERK1.	Quercetin	27-36	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	138-148
31529802-8	2019	The antifibrotic effect of quercetin was also determined by downregulation of mRNA or the levels of protein expression of Rac1-GTP, Rac1, HIF-1alpha, NOX1, and Sp1, along with ERK1.	Quercetin	27-36	NADPH oxidase 1	Rattus norvegicus	150-154
31529802-8	2019	The antifibrotic effect of quercetin was also determined by downregulation of mRNA or the levels of protein expression of Rac1-GTP, Rac1, HIF-1alpha, NOX1, and Sp1, along with ERK1.	Quercetin	27-36	mitogen activated protein kinase 3	Rattus norvegicus	176-180
31529802-9	2019	Our study indicates that quercetin may improve hepatic fibrosis via inhibiting ROS-associated inflammation as well as ameliorating hepatic IR by beneficial regulation of the STAT3/SOCS3/IRS1 signaling pathway.	Quercetin	25-34	signal transducer and activator of transcription 3	Rattus norvegicus	174-179
31529802-9	2019	Our study indicates that quercetin may improve hepatic fibrosis via inhibiting ROS-associated inflammation as well as ameliorating hepatic IR by beneficial regulation of the STAT3/SOCS3/IRS1 signaling pathway.	Quercetin	25-34	suppressor of cytokine signaling 3	Rattus norvegicus	180-185
31529802-9	2019	Our study indicates that quercetin may improve hepatic fibrosis via inhibiting ROS-associated inflammation as well as ameliorating hepatic IR by beneficial regulation of the STAT3/SOCS3/IRS1 signaling pathway.	Quercetin	25-34	insulin receptor substrate 1	Rattus norvegicus	186-190
31590760-0	2019	Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells.	Quercetin	0-9	advanced glycosylation end-product specific receptor	Homo sapiens	62-66
31590760-0	2019	Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	72-75
31590760-0	2019	Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	76-80
31590760-3	2019	Quercetin is a flavonoid that is abundant in apples, grapes, red raspberry, and onions and has been reported to inhibit RAGE.	Quercetin	0-9	advanced glycosylation end-product specific receptor	Homo sapiens	120-124
31590760-4	2019	This research aimed to investigate the mechanisms of quercetin in regulating cell death and enhancing drug effects through RAGE reduction, especially in GEM-resistant pancreatic cancer cells.	Quercetin	53-62	advanced glycosylation end-product specific receptor	Homo sapiens	123-127
31590760-6	2019	Notably, quercetin showed a dramatic effect similar to RAGE silencing that effectively attenuated RAGE expression to facilitate cell cycle arrest, autophagy, apoptosis, and GEM chemosensitivity in MIA Paca-2 GEMR cells, suggesting that an additional reaction occurred under combined quercetin and GEM treatment.	Quercetin	9-18	advanced glycosylation end-product specific receptor	Homo sapiens	98-102
31590760-7	2019	In conclusion, the results demonstrated that the molecular mechanisms of quercetin in regulating apoptosis and autophagy-related pathways and increasing GEM chemosensitivity in pancreatic cancer cells involved inhibition of RAGE expression.	Quercetin	73-82	advanced glycosylation end-product specific receptor	Homo sapiens	224-228
31338984-0	2019	Quercetin-Induced miR-369-3p Suppresses Chronic Inflammatory Response Targeting C/EBP-beta.	Quercetin	0-9	microRNA 369	Homo sapiens	18-27
31338984-0	2019	Quercetin-Induced miR-369-3p Suppresses Chronic Inflammatory Response Targeting C/EBP-beta.	Quercetin	0-9	CCAAT enhancer binding protein beta	Homo sapiens	80-90
31338984-5	2019	It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6).	Quercetin	88-97	microRNA 369	Homo sapiens	48-58
31338984-5	2019	It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6).	Quercetin	88-97	CCAAT enhancer binding protein beta	Homo sapiens	129-164
31338984-5	2019	It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6).	Quercetin	88-97	CCAAT enhancer binding protein beta	Homo sapiens	166-176
31338984-5	2019	It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6).	Quercetin	88-97	tumor necrosis factor	Homo sapiens	222-249
31338984-5	2019	It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6).	Quercetin	88-97	tumor necrosis factor	Homo sapiens	251-260
31338984-5	2019	It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6).	Quercetin	88-97	interleukin 6	Homo sapiens	266-279
31338984-5	2019	It is demonstrated that the loss of function of miR-369-3p in LPS-stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein beta (C/EBP-beta) mRNA and protein and its downstream targets tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL6).	Quercetin	88-97	interleukin 6	Homo sapiens	281-284
31338984-6	2019	Conversely, it is shown that the ectopic induction of miR-369-3p without quercetin suppresses the inflammatory response of LPS reducing C/EBP-beta, TNF-alpha, and IL6 production.	Quercetin	73-82	microRNA 369	Homo sapiens	54-64
31338984-7	2019	In vivo, oral administration of quercetin in dextran-sulfate-sodium-induced colitis induces miR-369-3p expression.	Quercetin	32-41	microRNA 369	Homo sapiens	92-102
31338984-8	2019	CONCLUSIONS: These findings indicate that quercetin-induced miR-369-3p regulates the inflammatory cascade in chronic inflammatory response and present promising therapeutic implications.	Quercetin	42-51	microRNA 369	Homo sapiens	60-70
31607321-7	2019	Western blot showed that the treatment with quercetin (2, 4 and 8 mumol/L) promoted the expression of anti-apoptotic protein BCL-2, inhibited the expression of pro-apoptotic protein BAX, resulting in a significant increase in the ratio of BCL-2/BAX (P<0.01), thereby inhibiting the apoptosis of platelets.	Quercetin	44-53	BCL2 apoptosis regulator	Homo sapiens	125-130
31539794-0	2019	Effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in broiler chickens.	Quercetin	23-32	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	79-86
31539794-2	2019	Naturally available phyto chemicals like piperine and quercetin as well as some floroquinolones are known to inhibit MDR1 and CYP3A37 activity and increases bioavailability of co-administered drugs.	Quercetin	54-63	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	126-133
31539794-3	2019	This study was carried out to investigate the effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in liver and intestine of broiler chicken.	Quercetin	69-78	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	125-132
31539794-6	2019	After piperine and quercetin combined treatment with marbofloxacin, CYP3A37 mRNA expression levels were significantly down regulated by 20.57 (p = .034) and 25.95 (p = .003) folds; and MDR1 mRNA expression levels were also significantly down regulated by 11.33 (p = .012) and 33.59 (p = .006) folds in liver and duodenum, respectively.	Quercetin	19-28	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	68-75
31539794-7	2019	Down regulation of CYP3A37 and MDR1 mRNA in liver and duodenum indicate the combined pretreatment of piperine and quercetin may be useful for improving the pharmacokinetics of orally administered drugs which are substrates for CYP3A37 and MDR1.	Quercetin	114-123	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	19-26
31539794-7	2019	Down regulation of CYP3A37 and MDR1 mRNA in liver and duodenum indicate the combined pretreatment of piperine and quercetin may be useful for improving the pharmacokinetics of orally administered drugs which are substrates for CYP3A37 and MDR1.	Quercetin	114-123	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	227-234
31607291-0	2019	[Effect of Quercetin on Wnt/beta-Catenin Signal Pathway of K562 and K562R Cells].	Quercetin	11-20	catenin beta 1	Homo sapiens	28-40
31607321-7	2019	Western blot showed that the treatment with quercetin (2, 4 and 8 mumol/L) promoted the expression of anti-apoptotic protein BCL-2, inhibited the expression of pro-apoptotic protein BAX, resulting in a significant increase in the ratio of BCL-2/BAX (P<0.01), thereby inhibiting the apoptosis of platelets.	Quercetin	44-53	BCL2 associated X, apoptosis regulator	Homo sapiens	182-185
31607321-7	2019	Western blot showed that the treatment with quercetin (2, 4 and 8 mumol/L) promoted the expression of anti-apoptotic protein BCL-2, inhibited the expression of pro-apoptotic protein BAX, resulting in a significant increase in the ratio of BCL-2/BAX (P<0.01), thereby inhibiting the apoptosis of platelets.	Quercetin	44-53	BCL2 apoptosis regulator	Homo sapiens	239-244
31607321-7	2019	Western blot showed that the treatment with quercetin (2, 4 and 8 mumol/L) promoted the expression of anti-apoptotic protein BCL-2, inhibited the expression of pro-apoptotic protein BAX, resulting in a significant increase in the ratio of BCL-2/BAX (P<0.01), thereby inhibiting the apoptosis of platelets.	Quercetin	44-53	BCL2 associated X, apoptosis regulator	Homo sapiens	245-248
31607321-9	2019	CONCLUSION: Quercetin can inhibit platelet apoptosis by increasing the ratio of apoptosis-related protein BCL-2/BAX in a concentration-dependent manner.	Quercetin	12-21	BCL2 apoptosis regulator	Homo sapiens	106-111
31607321-9	2019	CONCLUSION: Quercetin can inhibit platelet apoptosis by increasing the ratio of apoptosis-related protein BCL-2/BAX in a concentration-dependent manner.	Quercetin	12-21	BCL2 associated X, apoptosis regulator	Homo sapiens	112-115
31547402-0	2019	Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	56-61
31547402-0	2019	Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization.	Quercetin	0-9	interleukin 6	Homo sapiens	66-70
31547402-3	2019	The results obtained indicated that quercetin inhibited thectivation of signal transducer and activator of transcription 3 (STAT3) induced by EBV infection and reduced molecules such as interleukin-6 (IL-6) and reactive oxidative species (ROS) known to be essential for the immortalization process.	Quercetin	36-45	signal transducer and activator of transcription 3	Homo sapiens	72-122
31547402-3	2019	The results obtained indicated that quercetin inhibited thectivation of signal transducer and activator of transcription 3 (STAT3) induced by EBV infection and reduced molecules such as interleukin-6 (IL-6) and reactive oxidative species (ROS) known to be essential for the immortalization process.	Quercetin	36-45	signal transducer and activator of transcription 3	Homo sapiens	124-129
31547402-3	2019	The results obtained indicated that quercetin inhibited thectivation of signal transducer and activator of transcription 3 (STAT3) induced by EBV infection and reduced molecules such as interleukin-6 (IL-6) and reactive oxidative species (ROS) known to be essential for the immortalization process.	Quercetin	36-45	interleukin 6	Homo sapiens	186-199
31547402-3	2019	The results obtained indicated that quercetin inhibited thectivation of signal transducer and activator of transcription 3 (STAT3) induced by EBV infection and reduced molecules such as interleukin-6 (IL-6) and reactive oxidative species (ROS) known to be essential for the immortalization process.	Quercetin	36-45	interleukin 6	Homo sapiens	201-205
31547402-4	2019	Moreover, we found that quercetin promoted autophagy and counteracted the accumulation of sequestosome1/p62 (SQSTM1/p62), ultimately leading to the prevention of B cell immortalization.	Quercetin	24-33	sequestosome 1	Homo sapiens	90-103
31547402-4	2019	Moreover, we found that quercetin promoted autophagy and counteracted the accumulation of sequestosome1/p62 (SQSTM1/p62), ultimately leading to the prevention of B cell immortalization.	Quercetin	24-33	sequestosome 1	Homo sapiens	104-107
31547402-4	2019	Moreover, we found that quercetin promoted autophagy and counteracted the accumulation of sequestosome1/p62 (SQSTM1/p62), ultimately leading to the prevention of B cell immortalization.	Quercetin	24-33	sequestosome 1	Homo sapiens	109-115
31547402-4	2019	Moreover, we found that quercetin promoted autophagy and counteracted the accumulation of sequestosome1/p62 (SQSTM1/p62), ultimately leading to the prevention of B cell immortalization.	Quercetin	24-33	sequestosome 1	Homo sapiens	116-119
31228705-4	2019	Owing to the ROS scavenging ability of quercetin, Qu-FeIIP effectively reduces intracellular ROS and in vivo inflammatory factors (TNF-alpha, IL-6, IFN-gamma) levels.	Quercetin	39-48	tumor necrosis factor	Homo sapiens	131-140
31660141-6	2019	Alternating the consumption of beta-glucan and quercetin significantly decreased the TNF-alpha level, increased the relative abundance of Parabacteroides, and downregulated three genes (Hmgcs2, Fabp2, and Gpt) that are associated with inflammation and cancer.	Quercetin	47-56	fatty acid binding protein 2, intestinal	Mus musculus	194-199
31660141-6	2019	Alternating the consumption of beta-glucan and quercetin significantly decreased the TNF-alpha level, increased the relative abundance of Parabacteroides, and downregulated three genes (Hmgcs2, Fabp2, and Gpt) that are associated with inflammation and cancer.	Quercetin	47-56	glutamic pyruvic transaminase, soluble	Mus musculus	205-208
31660141-6	2019	Alternating the consumption of beta-glucan and quercetin significantly decreased the TNF-alpha level, increased the relative abundance of Parabacteroides, and downregulated three genes (Hmgcs2, Fabp2, and Gpt) that are associated with inflammation and cancer.	Quercetin	47-56	tumor necrosis factor	Mus musculus	85-94
31660141-6	2019	Alternating the consumption of beta-glucan and quercetin significantly decreased the TNF-alpha level, increased the relative abundance of Parabacteroides, and downregulated three genes (Hmgcs2, Fabp2, and Gpt) that are associated with inflammation and cancer.	Quercetin	47-56	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	186-192
31480735-0	2019	Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1.	Quercetin	0-9	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	75-82
31480735-6	2019	We found that hnRNPA1, a nuclear protein known to control mRNA export and mRNA translation of anti-apoptotic proteins, mediates some anti-tumor effects by Quercetin.	Quercetin	155-164	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	14-21
31480735-8	2019	Significantly, Quercetin decreased hnRNPA1 in vivo and enhanced the effects of BET inhibitors at suppressing tumor growth.	Quercetin	15-24	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	35-42
31480735-9	2019	Together, these results demonstrate that Quercetin enhances the efficacy of BET inhibitors by suppressing hnRNPA1, and identify combination therapy with Quercetin and BET inhibitors for the treatment of cancer patients.	Quercetin	41-50	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	106-113
31228705-4	2019	Owing to the ROS scavenging ability of quercetin, Qu-FeIIP effectively reduces intracellular ROS and in vivo inflammatory factors (TNF-alpha, IL-6, IFN-gamma) levels.	Quercetin	39-48	interleukin 6	Homo sapiens	142-146
31228705-4	2019	Owing to the ROS scavenging ability of quercetin, Qu-FeIIP effectively reduces intracellular ROS and in vivo inflammatory factors (TNF-alpha, IL-6, IFN-gamma) levels.	Quercetin	39-48	interferon gamma	Homo sapiens	148-157
31247404-2	2019	Using surface plasmon resonance, we demonstrated that beta-casein (beta-cas) and quercetin (Qct) form supramolecular complexes driven by an increase in entropy (DeltaH  = 25.86 and TDeltaS  =53.49 kJ mol-1 at 25  C).	Quercetin	81-90	casein beta	Homo sapiens	54-65
31247404-2	2019	Using surface plasmon resonance, we demonstrated that beta-casein (beta-cas) and quercetin (Qct) form supramolecular complexes driven by an increase in entropy (DeltaH  = 25.86 and TDeltaS  =53.49 kJ mol-1 at 25  C).	Quercetin	81-90	casein beta	Homo sapiens	54-62
31301179-0	2019	Activation of Nrf2 signaling by sitagliptin and quercetin combination against beta-amyloid induced Alzheimer"s disease in rats.	Quercetin	48-57	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
31228815-0	2019	Quercetin attenuates hypoxia-ischemia induced brain injury in neonatal rats by inhibiting TLR4/NF-kappaB signaling pathway.	Quercetin	0-9	toll-like receptor 4	Rattus norvegicus	90-94
31233792-0	2019	Investigation of inhibitory potential of quercetin to the pyruvate dehydrogenase kinase 3: Towards implications in anticancer therapy.	Quercetin	41-50	pyruvate dehydrogenase kinase 3	Homo sapiens	58-89
31233792-10	2019	All these observations clearly indicate that quercetin may be further evaluated as promising therapeutic molecule for PDK3 with required modifications and in vivo validation.	Quercetin	45-54	pyruvate dehydrogenase kinase 3	Homo sapiens	118-122
31233792-2	2019	Here, we report the binding mechanism of quercetin to the PDK3 by using molecular docking, simulation, fluorescence spectroscopy and isothermal titration calorimetric assays.	Quercetin	41-50	pyruvate dehydrogenase kinase 3	Homo sapiens	58-62
31207328-0	2019	Chemometrical-electrochemical investigation for comparing inhibitory effects of quercetin and its sulfonamide derivative on human carbonic anhydrase II: Theoretical and experimental evidence.	Quercetin	80-89	carbonic anhydrase 2	Homo sapiens	130-151
31233792-4	2019	We have observed that quercetin interacts to the important residues of active site cavity of PDK3 and shows a well-ordered conformational fitting.	Quercetin	22-31	pyruvate dehydrogenase kinase 3	Homo sapiens	93-97
31207328-1	2019	This paper reports results of a valuable study on investigation of inhibitory effects of the sulfonamide derivative of quercetin (QD) on human carbonic anhydrase II (CA-II) by electrochemical and chemometrical approaches.	Quercetin	119-128	carbonic anhydrase 2	Homo sapiens	143-164
31233792-5	2019	The stability of quercetin-PDK3 complex is maintained by several non-covalent interactions throughout the simulation.	Quercetin	17-26	pyruvate dehydrogenase kinase 3	Homo sapiens	27-31
31207328-1	2019	This paper reports results of a valuable study on investigation of inhibitory effects of the sulfonamide derivative of quercetin (QD) on human carbonic anhydrase II (CA-II) by electrochemical and chemometrical approaches.	Quercetin	119-128	carbonic anhydrase 2	Homo sapiens	166-171
31233792-7	2019	Both fluorescence and isothermal titration calorimetric experiments showed excellent binding affinity of quercetin to the PDK3.	Quercetin	105-114	pyruvate dehydrogenase kinase 3	Homo sapiens	122-126
31207328-4	2019	Finally, a novel EIS technique based on interaction of Q and CA-II was developed for sensitive electroanalytical determination of CA-II and in this section of our study, the sensitivity of the developed electroanalytical methodology was improved by the modification of the GCE was with multi-walled carbon nanotubes-ionic liquid.	Quercetin	55-56	carbonic anhydrase 2	Homo sapiens	130-135
31233792-8	2019	Kinase inhibition assay further revealed a significant inhibitory potential of quercetin to the PDK3 with the IC50 values in muM range.	Quercetin	79-88	pyruvate dehydrogenase kinase 3	Homo sapiens	96-100
31317585-0	2019	Quercetin reduces TNF-alpha-induced mesangial cell proliferation and inhibits PTX3 production: Involvement of NF-kappaB signaling pathway.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	18-27
31524223-1	2019	The aim of this study was to investigate the mechanisms through which quercetin protects against atherosclerosis (AS) in apoE-/- mice by regulating the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9), cluster of differentiation 36 (CD36), peroxisome proliferator-activated receptor gamma (PPARgamma), liver X receptor alpha (LXRalpha) and ATP binding cassette transporter A1 (ABCA1).	Quercetin	70-79	proprotein convertase subtilisin/kexin type 9	Mus musculus	213-218
31524223-15	2019	On the whole, these results demonstrate that quercetin prevents the development of AS in apoE-/- mice by regulating the expression of PCSK9, CD36, PPARgamma, LXRalpha and ABCA1.	Quercetin	45-54	apolipoprotein E	Mus musculus	89-93
31524223-15	2019	On the whole, these results demonstrate that quercetin prevents the development of AS in apoE-/- mice by regulating the expression of PCSK9, CD36, PPARgamma, LXRalpha and ABCA1.	Quercetin	45-54	proprotein convertase subtilisin/kexin type 9	Mus musculus	134-139
31332904-0	2019	Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway.	Quercetin	0-9	sirtuin 1	Homo sapiens	86-91
31332904-0	2019	Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	92-95
31524223-0	2019	Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPARgamma, LXRalpha and ABCA1.	Quercetin	0-9	proprotein convertase subtilisin/kexin type 9	Mus musculus	75-80
31524223-1	2019	The aim of this study was to investigate the mechanisms through which quercetin protects against atherosclerosis (AS) in apoE-/- mice by regulating the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9), cluster of differentiation 36 (CD36), peroxisome proliferator-activated receptor gamma (PPARgamma), liver X receptor alpha (LXRalpha) and ATP binding cassette transporter A1 (ABCA1).	Quercetin	70-79	apolipoprotein E	Mus musculus	121-125
31524223-1	2019	The aim of this study was to investigate the mechanisms through which quercetin protects against atherosclerosis (AS) in apoE-/- mice by regulating the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9), cluster of differentiation 36 (CD36), peroxisome proliferator-activated receptor gamma (PPARgamma), liver X receptor alpha (LXRalpha) and ATP binding cassette transporter A1 (ABCA1).	Quercetin	70-79	proprotein convertase subtilisin/kexin type 9	Mus musculus	166-211
31496875-0	2019	Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner.	Quercetin	40-49	potassium calcium-activated channel subfamily U member 1	Homo sapiens	65-69
31496875-2	2019	Onion peel extract (OPE) and its major active ingredient quercetin are widely used as fertility enhancers; however, the effect of OPE and quercetin on Slo3 has not been elucidated.	Quercetin	138-147	potassium calcium-activated channel subfamily U member 1	Homo sapiens	151-155
31496875-3	2019	The purpose of this study is to investigate the effect of quercetin on human Slo3 channels.	Quercetin	58-67	potassium calcium-activated channel subfamily U member 1	Homo sapiens	77-81
31496875-6	2019	We found that OPE and its key ingredient quercetin inhibit Slo3 currents.	Quercetin	41-50	potassium calcium-activated channel subfamily U member 1	Homo sapiens	59-63
31496875-8	2019	Functional moieties in the quercetin polyphenolic ring govern the degree of inhibition of Slo3 by quercetin, and the composition of such functional moieties are sensitive to the pH of the medium.	Quercetin	27-36	potassium calcium-activated channel subfamily U member 1	Homo sapiens	90-94
31496875-8	2019	Functional moieties in the quercetin polyphenolic ring govern the degree of inhibition of Slo3 by quercetin, and the composition of such functional moieties are sensitive to the pH of the medium.	Quercetin	98-107	potassium calcium-activated channel subfamily U member 1	Homo sapiens	90-94
31496875-9	2019	These results suggest that quercetin inhibits Slo3 in a pH and calcium dependent manner.	Quercetin	27-36	potassium calcium-activated channel subfamily U member 1	Homo sapiens	46-50
31496875-10	2019	Therefore, we surmise that quercetin induced depolarization in spermatozoa may enhance the voltage gated proton channel (Hv1), and activate non-selective cation channels of sperm (CatSper) dependent calcium influx to trigger sperm capacitation and acrosome reaction.	Quercetin	27-36	hydrogen voltage gated channel 1	Homo sapiens	121-124
31295570-3	2019	Available experimental studies indicate that quercetin could modulate multiple cancer-relevant miRNAs including let-7, miR-21, miR-146a and miR-155, thereby inhibiting cancer initiation and development.	Quercetin	45-54	microRNA 21	Homo sapiens	119-125
31295570-3	2019	Available experimental studies indicate that quercetin could modulate multiple cancer-relevant miRNAs including let-7, miR-21, miR-146a and miR-155, thereby inhibiting cancer initiation and development.	Quercetin	45-54	microRNA 146a	Homo sapiens	127-135
31295570-3	2019	Available experimental studies indicate that quercetin could modulate multiple cancer-relevant miRNAs including let-7, miR-21, miR-146a and miR-155, thereby inhibiting cancer initiation and development.	Quercetin	45-54	microRNA 155	Homo sapiens	140-147
31317585-0	2019	Quercetin reduces TNF-alpha-induced mesangial cell proliferation and inhibits PTX3 production: Involvement of NF-kappaB signaling pathway.	Quercetin	0-9	pentraxin 3	Homo sapiens	78-82
31317585-0	2019	Quercetin reduces TNF-alpha-induced mesangial cell proliferation and inhibits PTX3 production: Involvement of NF-kappaB signaling pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	110-119
31317585-6	2019	ELISA and immunofluorescence experiments showed that quercetin treatment inhibited the expression of PTX3.	Quercetin	53-62	pentraxin 3	Homo sapiens	101-105
31317585-10	2019	Western blot and qRT-PCR analysis revealed that quercetin treatment reduced the expression of nuclear factor-kappaB p65 and IKKbeta, increased the expression of IkappaBalpha, and inhibited the expression of PTX3.	Quercetin	48-57	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	124-131
31383475-0	2019	Quercetin protects human granulosa cells against oxidative stress via thioredoxin system.	Quercetin	0-9	thioredoxin	Homo sapiens	70-81
31317585-10	2019	Western blot and qRT-PCR analysis revealed that quercetin treatment reduced the expression of nuclear factor-kappaB p65 and IKKbeta, increased the expression of IkappaBalpha, and inhibited the expression of PTX3.	Quercetin	48-57	NFKB inhibitor alpha	Homo sapiens	161-173
31383475-2	2019	Quercetin (QUR) is a free radical scavenger which can alleviate oxidative stress through nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/antioxidant response element (ARE) pathway and thioredoxin (Trx) system.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
31383475-2	2019	Quercetin (QUR) is a free radical scavenger which can alleviate oxidative stress through nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/antioxidant response element (ARE) pathway and thioredoxin (Trx) system.	Quercetin	0-9	thioredoxin	Homo sapiens	187-198
31317585-10	2019	Western blot and qRT-PCR analysis revealed that quercetin treatment reduced the expression of nuclear factor-kappaB p65 and IKKbeta, increased the expression of IkappaBalpha, and inhibited the expression of PTX3.	Quercetin	48-57	pentraxin 3	Homo sapiens	207-211
31383475-2	2019	Quercetin (QUR) is a free radical scavenger which can alleviate oxidative stress through nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/antioxidant response element (ARE) pathway and thioredoxin (Trx) system.	Quercetin	0-9	thioredoxin	Homo sapiens	200-203
31317585-11	2019	In conclusion, through inhibiting the activation of nuclear factor-kappaB signaling pathway, quercetin treatment could reduce the expression of PTX3 and inhibit the excessive proliferation of mesangial cells, suggesting that quercetin is a potential therapeutic drug for LN.	Quercetin	93-102	pentraxin 3	Homo sapiens	144-148
31317585-11	2019	In conclusion, through inhibiting the activation of nuclear factor-kappaB signaling pathway, quercetin treatment could reduce the expression of PTX3 and inhibit the excessive proliferation of mesangial cells, suggesting that quercetin is a potential therapeutic drug for LN.	Quercetin	225-234	pentraxin 3	Homo sapiens	144-148
31602954-4	2019	The results showed that both quercetin and glabridin could decrease the glucose uptake capacity of breast cancer cells by down-regulating the protein expression of GLUT1.	Quercetin	29-38	solute carrier family 2 member 1	Homo sapiens	164-169
32012499-0	2019	Quercetin potentiates antiradical properties of epigallocatechin-3-gallate in periodontium of rats under systemic and local administration of lipopolisaccharide of salmonella typhi Introduction: There has been demonstrated that pharmaceutical effect of epigallocatechin-3-gallate (EGCG), a polyphenol, which is found in green tea (Camellia sinensis), is implemented through the activation of Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2).The importance of Keap1 / Nrf2 / antioxidant response element (ARE) system is determined by the fact that the state of NF-kappaB- and AR-1-associated pathways depends on its activity.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	392-396
32012499-0	2019	Quercetin potentiates antiradical properties of epigallocatechin-3-gallate in periodontium of rats under systemic and local administration of lipopolisaccharide of salmonella typhi Introduction: There has been demonstrated that pharmaceutical effect of epigallocatechin-3-gallate (EGCG), a polyphenol, which is found in green tea (Camellia sinensis), is implemented through the activation of Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2).The importance of Keap1 / Nrf2 / antioxidant response element (ARE) system is determined by the fact that the state of NF-kappaB- and AR-1-associated pathways depends on its activity.	Quercetin	0-9	Kelch-like ECH-associated protein 1	Rattus norvegicus	461-466
31531360-11	2019	In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB.	Quercetin	44-53	peroxisome proliferator activated receptor gamma	Homo sapiens	167-177
32012499-0	2019	Quercetin potentiates antiradical properties of epigallocatechin-3-gallate in periodontium of rats under systemic and local administration of lipopolisaccharide of salmonella typhi Introduction: There has been demonstrated that pharmaceutical effect of epigallocatechin-3-gallate (EGCG), a polyphenol, which is found in green tea (Camellia sinensis), is implemented through the activation of Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2).The importance of Keap1 / Nrf2 / antioxidant response element (ARE) system is determined by the fact that the state of NF-kappaB- and AR-1-associated pathways depends on its activity.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	469-473
31461866-4	2019	The mMIP was synthesized previously using quercetin as dummy template, and here we wanted to test its applicability to complex food samples.	Quercetin	42-51	major intrinsic protein of lens fiber	Mus musculus	4-8
31461866-8	2019	Although the mMIP showed cross-selectivity towards both ZEN-related and quercetin-related compounds, nonetheless ZEN recovery was &gt; 95% for the two lower spiking levels, and the quantification limit was 0.14 ng g-1, i.e., ca.	Quercetin	72-81	major intrinsic protein of lens fiber	Mus musculus	13-17
31531360-0	2019	Quercetin Inhibits Inflammatory Response Induced by LPS from Porphyromonas gingivalis in Human Gingival Fibroblasts via Suppressing NF-kappaB Signaling Pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	132-141
31531360-8	2019	Our results demonstrated that quercetin inhibited the LPS-induced production of IL-1beta, IL-6, IL-8, and TNF-alpha in a dose-dependent manner.	Quercetin	30-39	interleukin 1 alpha	Homo sapiens	80-88
31531360-8	2019	Our results demonstrated that quercetin inhibited the LPS-induced production of IL-1beta, IL-6, IL-8, and TNF-alpha in a dose-dependent manner.	Quercetin	30-39	interleukin 6	Homo sapiens	90-94
31531360-8	2019	Our results demonstrated that quercetin inhibited the LPS-induced production of IL-1beta, IL-6, IL-8, and TNF-alpha in a dose-dependent manner.	Quercetin	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
31531360-8	2019	Our results demonstrated that quercetin inhibited the LPS-induced production of IL-1beta, IL-6, IL-8, and TNF-alpha in a dose-dependent manner.	Quercetin	30-39	tumor necrosis factor	Homo sapiens	106-115
31531360-10	2019	Moreover, the anti-inflammatory effects of quercetin were reversed by the PPAR-gamma antagonist of GW9662.	Quercetin	43-52	peroxisome proliferator activated receptor gamma	Homo sapiens	74-84
31531360-11	2019	In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB.	Quercetin	44-53	interleukin 1 alpha	Homo sapiens	83-91
31531360-11	2019	In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB.	Quercetin	44-53	interleukin 6	Homo sapiens	93-97
31311265-9	2019	After the optimization process, the best sensitivity was obtained for gallic acid, quercetin, catechin, kaempferol, and caffeic acid with detection limits of 0.98, 1.36, 1.48, 1.81, and 2.55 ng mL-1, respectively.	Quercetin	83-92	2'-5' oligoadenylate synthetase 1B	Mus musculus	194-198
31531360-11	2019	In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB.	Quercetin	44-53	nuclear factor kappa B subunit 1	Homo sapiens	226-235
31531360-11	2019	In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB.	Quercetin	44-53	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
31531360-11	2019	In conclusion, these results suggested that quercetin attenuated the production of IL-1beta, IL-6, IL-8, and TNF-alpha in P. gingivalis LPS-treated HGFs by activating PPAR-gamma which subsequently suppressed the activation of NF-kappaB.	Quercetin	44-53	tumor necrosis factor	Homo sapiens	109-118
31251921-0	2019	Quercetin suppressed NADPH oxidase-derived oxidative stress via heme oxygenase-1 induction in macrophages.	Quercetin	0-9	heme oxygenase 1	Mus musculus	64-80
31467991-0	2019	Antifibrotic effect of methylated quercetin derivatives on TGFbeta-induced hepatic stellate cells.	Quercetin	34-43	transforming growth factor, beta 1	Rattus norvegicus	59-66
31251921-2	2019	Quercetin, widely known for their anti-oxidant and anti-inflammatory properties in vitro and in vivo, is recently identified to induce expression of antioxidant enzyme heme oxygenase-1 (HO-1).	Quercetin	0-9	heme oxygenase 1	Mus musculus	168-184
31251921-7	2019	The induction of HO-1 by quercetin was associated with the nuclear accumulation of Nrf2 and downregulation of Keap1, a negative regulator of Nrf2.	Quercetin	25-34	heme oxygenase 1	Mus musculus	17-21
31251921-2	2019	Quercetin, widely known for their anti-oxidant and anti-inflammatory properties in vitro and in vivo, is recently identified to induce expression of antioxidant enzyme heme oxygenase-1 (HO-1).	Quercetin	0-9	heme oxygenase 1	Mus musculus	186-190
31251921-7	2019	The induction of HO-1 by quercetin was associated with the nuclear accumulation of Nrf2 and downregulation of Keap1, a negative regulator of Nrf2.	Quercetin	25-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
31251921-7	2019	The induction of HO-1 by quercetin was associated with the nuclear accumulation of Nrf2 and downregulation of Keap1, a negative regulator of Nrf2.	Quercetin	25-34	kelch-like ECH-associated protein 1	Mus musculus	110-115
31251921-4	2019	In this study, we tested whether quercetin might modulate NADPH oxidase activity in macrophages via induction of HO-1.	Quercetin	33-42	heme oxygenase 1	Mus musculus	113-117
31251921-7	2019	The induction of HO-1 by quercetin was associated with the nuclear accumulation of Nrf2 and downregulation of Keap1, a negative regulator of Nrf2.	Quercetin	25-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	141-145
31251921-5	2019	In RAW264.7 macrophages, quercetin significantly attenuated NADPH oxidase-derived O2.- generation via a HO-1-dependent mechanism.	Quercetin	25-34	heme oxygenase 1	Mus musculus	104-108
31251921-9	2019	In agreement with the observations in macrophages, pretreatment with quercetin significantly alleviated LPS-induced inflammation in mice which was concomitant with decreased NADPH oxidase activity and increased HO-1 expression.	Quercetin	69-78	heme oxygenase 1	Mus musculus	211-215
31251921-11	2019	Suppression of NADPH oxidase-dependent oxidative stress may represent a novel mechanism underlying the anti-oxidant and anti-inflammatory properties of quercetin/HO-1 pathway.	Quercetin	152-161	heme oxygenase 1	Mus musculus	162-166
31251921-6	2019	Mechanistically, the protective effects of quercetin were (1) linked to increased expression of HO-1 in the presence or absence of lipopolysaccharide (LPS), (2) similar to that observed with the NADPH oxidase inhibitor apocynin, and (3) could be abolished by the specific small-interfering RNA against HO-1 expression or HO-1 activity inhibitor tin protoporphyrin.	Quercetin	43-52	heme oxygenase 1	Mus musculus	96-100
31251921-6	2019	Mechanistically, the protective effects of quercetin were (1) linked to increased expression of HO-1 in the presence or absence of lipopolysaccharide (LPS), (2) similar to that observed with the NADPH oxidase inhibitor apocynin, and (3) could be abolished by the specific small-interfering RNA against HO-1 expression or HO-1 activity inhibitor tin protoporphyrin.	Quercetin	43-52	heme oxygenase 1	Mus musculus	302-306
31497191-0	2019	Quercetin improves blood-brain barrier dysfunction in rats with cerebral ischemia reperfusion via Wnt signaling pathway.	Quercetin	0-9	Wnt family member 2	Rattus norvegicus	98-101
31251921-6	2019	Mechanistically, the protective effects of quercetin were (1) linked to increased expression of HO-1 in the presence or absence of lipopolysaccharide (LPS), (2) similar to that observed with the NADPH oxidase inhibitor apocynin, and (3) could be abolished by the specific small-interfering RNA against HO-1 expression or HO-1 activity inhibitor tin protoporphyrin.	Quercetin	43-52	heme oxygenase 1	Mus musculus	302-306
31103824-9	2019	In the uterus, quercetin supplement to aspirin prevented the expression of VEGF and sFlt-1 mRNA.	Quercetin	15-24	vascular endothelial growth factor A	Rattus norvegicus	75-79
31497191-10	2019	Quercetin could increase the expression of ZO-1, Claudin-5, beta-catenin, and LEF1, and decrease the expression of MMP-9, GSK-3beta and Axin.	Quercetin	0-9	tight junction protein 1	Rattus norvegicus	43-47
31497191-10	2019	Quercetin could increase the expression of ZO-1, Claudin-5, beta-catenin, and LEF1, and decrease the expression of MMP-9, GSK-3beta and Axin.	Quercetin	0-9	claudin 5	Rattus norvegicus	49-58
31497191-10	2019	Quercetin could increase the expression of ZO-1, Claudin-5, beta-catenin, and LEF1, and decrease the expression of MMP-9, GSK-3beta and Axin.	Quercetin	0-9	catenin beta 1	Rattus norvegicus	60-72
31497191-10	2019	Quercetin could increase the expression of ZO-1, Claudin-5, beta-catenin, and LEF1, and decrease the expression of MMP-9, GSK-3beta and Axin.	Quercetin	0-9	lymphoid enhancer binding factor 1	Rattus norvegicus	78-82
31497191-10	2019	Quercetin could increase the expression of ZO-1, Claudin-5, beta-catenin, and LEF1, and decrease the expression of MMP-9, GSK-3beta and Axin.	Quercetin	0-9	matrix metallopeptidase 9	Rattus norvegicus	115-120
31497191-10	2019	Quercetin could increase the expression of ZO-1, Claudin-5, beta-catenin, and LEF1, and decrease the expression of MMP-9, GSK-3beta and Axin.	Quercetin	0-9	glycogen synthase kinase 3 beta	Rattus norvegicus	122-131
31497191-10	2019	Quercetin could increase the expression of ZO-1, Claudin-5, beta-catenin, and LEF1, and decrease the expression of MMP-9, GSK-3beta and Axin.	Quercetin	0-9	axin 1	Rattus norvegicus	136-140
31497191-11	2019	And all these protective effects of quercetin could be reversed by DKK-1.	Quercetin	36-45	dickkopf WNT signaling pathway inhibitor 1	Rattus norvegicus	67-72
31497191-12	2019	Thus, quercetin can alleviate BBB dysfunction after global cerebral I/R in rats and the mechanism may be related to the activation of canonical Wnt/beta-catenin signaling pathway.	Quercetin	6-15	Wnt family member 2	Rattus norvegicus	144-147
31497191-12	2019	Thus, quercetin can alleviate BBB dysfunction after global cerebral I/R in rats and the mechanism may be related to the activation of canonical Wnt/beta-catenin signaling pathway.	Quercetin	6-15	catenin beta 1	Rattus norvegicus	148-160
31071329-5	2019	Our results show that natural flavonoids inhibited purified and membranous PMCA with different effectiveness: quercetin and gossypin were the most potent and their inhibition mechanisms seem to be different, as quercetin does not prevent ATP binding whereas gossypin does.	Quercetin	110-119	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	75-79
31366565-9	2019	Quercetin induces apoptosis via activating both apoptotic pathways with a stronger effect of the extrinsic pathway relying on the combined power of TRAIL, FASL and TNF with up-regulation of caspases and pro-apoptotic genes.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	148-153
31366565-9	2019	Quercetin induces apoptosis via activating both apoptotic pathways with a stronger effect of the extrinsic pathway relying on the combined power of TRAIL, FASL and TNF with up-regulation of caspases and pro-apoptotic genes.	Quercetin	0-9	Fas ligand	Homo sapiens	155-159
31366565-9	2019	Quercetin induces apoptosis via activating both apoptotic pathways with a stronger effect of the extrinsic pathway relying on the combined power of TRAIL, FASL and TNF with up-regulation of caspases and pro-apoptotic genes.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	164-167
31431821-6	2019	Highly expressed miR-155 has been downregulated by flavonoids (through a quercetin-rich diet) and by vitamin D.	Quercetin	73-82	microRNA 155	Homo sapiens	17-24
31431821-7	2019	Quercetin has been effective in modulating miR-146a.	Quercetin	0-9	microRNA 146a	Homo sapiens	43-51
31377749-0	2019	Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression.	Quercetin	0-9	high mobility group box 1	Rattus norvegicus	132-157
31377749-0	2019	Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression.	Quercetin	0-9	high mobility group box 1	Rattus norvegicus	159-164
31377749-13	2019	The activities and the expression of SOD, CAT, and APX were significantly decreased upon administration of quercetin in the septic rats at the dosage of 15 and 20 mg/kg.	Quercetin	107-116	catalase	Rattus norvegicus	42-45
31377749-14	2019	The effects of quercetin were also examined on the expression of the High mobility group box 1 (HMGB1) protein in septic rats.	Quercetin	15-24	high mobility group box 1	Rattus norvegicus	69-94
31377749-14	2019	The effects of quercetin were also examined on the expression of the High mobility group box 1 (HMGB1) protein in septic rats.	Quercetin	15-24	high mobility group box 1	Rattus norvegicus	96-101
31377749-15	2019	The results showed that quercetin caused a significant decrease in HMGB1 protein levels.	Quercetin	24-33	high mobility group box 1	Rattus norvegicus	67-72
31592433-10	2019	FT-IR suggested by a shift of frequency of the carbonyl group (1661 cm-1) that the quercetin bond to antimony by the C-3, followed by positions C-5 and C-4 carbonyl, which has been confirmed by MIC through the structure-activity relationship of the antibacterial activity of quercetin.	Quercetin	83-92	complement C3	Homo sapiens	117-120
31592433-10	2019	FT-IR suggested by a shift of frequency of the carbonyl group (1661 cm-1) that the quercetin bond to antimony by the C-3, followed by positions C-5 and C-4 carbonyl, which has been confirmed by MIC through the structure-activity relationship of the antibacterial activity of quercetin.	Quercetin	83-92	complement C5	Homo sapiens	144-147
31592433-10	2019	FT-IR suggested by a shift of frequency of the carbonyl group (1661 cm-1) that the quercetin bond to antimony by the C-3, followed by positions C-5 and C-4 carbonyl, which has been confirmed by MIC through the structure-activity relationship of the antibacterial activity of quercetin.	Quercetin	83-92	complement C4A (Rodgers blood group)	Homo sapiens	152-155
31273958-0	2019	Quercetin shows anti-tumor effect in hepatocellular carcinoma LM3 cells by abrogating JAK2/STAT3 signaling pathway.	Quercetin	0-9	Janus kinase 2	Mus musculus	86-90
31273958-0	2019	Quercetin shows anti-tumor effect in hepatocellular carcinoma LM3 cells by abrogating JAK2/STAT3 signaling pathway.	Quercetin	0-9	signal transducer and activator of transcription 3	Mus musculus	91-96
31273958-9	2019	These effects at least partly depended on the down-regulation of the activation of JAK2 and STAT3 by quercetin.	Quercetin	101-110	Janus kinase 2	Mus musculus	83-87
31273958-9	2019	These effects at least partly depended on the down-regulation of the activation of JAK2 and STAT3 by quercetin.	Quercetin	101-110	signal transducer and activator of transcription 3	Mus musculus	92-97
31273958-10	2019	CONCLUSION: Quercetin inhibited hepatocellular carcinoma progression by modulating cell apoptosis, migration, invasion, and autophagy; and its effects were at least partly related with the JAK2/STAT3 signaling pathway.	Quercetin	12-21	Janus kinase 2	Mus musculus	189-193
31273958-10	2019	CONCLUSION: Quercetin inhibited hepatocellular carcinoma progression by modulating cell apoptosis, migration, invasion, and autophagy; and its effects were at least partly related with the JAK2/STAT3 signaling pathway.	Quercetin	12-21	signal transducer and activator of transcription 3	Mus musculus	194-199
30916407-11	2019	Natural products like berberine, quercetin, resveratrol, and so forth have shown significant potential in regulating and activating the AMPK pathway which can lead to manage diabetes mellitus and its complications.	Quercetin	33-42	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	136-140
30101388-11	2019	Two hours after quercetin injection there was a significant increase in tumor AACID by 0.07 +- 0.03 corresponding to a 0.27 decrease in pHi, and no change in AACID in contralateral tissue.	Quercetin	16-25	glucose-6-phosphate isomerase 1	Mus musculus	136-139
30854676-0	2019	Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	60-65
30854676-0	2019	Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	66-70
30854676-7	2019	Moreover, quercetin inhibited ER stress through activating the sirtuin1/adenosine monophosphate-activated protein kinase (SIRT1/AMPK) signaling pathway.	Quercetin	10-19	sirtuin 1	Rattus norvegicus	122-127
30854676-7	2019	Moreover, quercetin inhibited ER stress through activating the sirtuin1/adenosine monophosphate-activated protein kinase (SIRT1/AMPK) signaling pathway.	Quercetin	10-19	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	128-132
30990955-13	2019	Interestingly, when chlorpyrifos-treated animals were supplemented with quercetin, a significant increase in the expression of Bcl-2 and an appreciable decline in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 was observed.	Quercetin	72-81	BCL2, apoptosis regulator	Rattus norvegicus	127-132
30990955-13	2019	Interestingly, when chlorpyrifos-treated animals were supplemented with quercetin, a significant increase in the expression of Bcl-2 and an appreciable decline in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 was observed.	Quercetin	72-81	BCL2 associated X, apoptosis regulator	Rattus norvegicus	188-191
30990955-13	2019	Interestingly, when chlorpyrifos-treated animals were supplemented with quercetin, a significant increase in the expression of Bcl-2 and an appreciable decline in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 was observed.	Quercetin	72-81	caspase 8	Rattus norvegicus	207-216
30990955-13	2019	Interestingly, when chlorpyrifos-treated animals were supplemented with quercetin, a significant increase in the expression of Bcl-2 and an appreciable decline in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 was observed.	Quercetin	72-81	caspase 9	Rattus norvegicus	222-231
31418363-9	2019	The results of transcriptome sequencing analysis showed that the expression of Ighv1-84 and Igkv6-14 in adriamycin combined quercetin group and quercetin group was lower than that in adriamycin group.	Quercetin	124-133	immunoglobulin heavy variable 1-84	Mus musculus	79-87
30589076-0	2019	Quercetin sensitizes human myeloid leukemia KG-1 cells against TRAIL-induced apoptosis.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	63-68
30609021-5	2019	Quercetin treatment at 37 C induced mitochondrial fragmentation and decreased membrane potential (DeltaPsi m ), accompanied by reduced protein expression of the master regulator of mitochondrial biogenesis peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha).	Quercetin	0-9	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	206-273
30609021-5	2019	Quercetin treatment at 37 C induced mitochondrial fragmentation and decreased membrane potential (DeltaPsi m ), accompanied by reduced protein expression of the master regulator of mitochondrial biogenesis peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha).	Quercetin	0-9	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	275-285
31418363-10	2019	The Ms4a1, Podx1, Mecom, Sh3bgr12, Bex4 and Tdrp expression in adriamycin combined quercetin group and adriamycin group were higher than that in quercetin group, while Crabp1 expression was lower.	Quercetin	83-92	testis development related protein	Mus musculus	44-48
31418363-9	2019	The results of transcriptome sequencing analysis showed that the expression of Ighv1-84 and Igkv6-14 in adriamycin combined quercetin group and quercetin group was lower than that in adriamycin group.	Quercetin	124-133	immunoglobulin kappa variable 6-14	Mus musculus	92-100
31418363-9	2019	The results of transcriptome sequencing analysis showed that the expression of Ighv1-84 and Igkv6-14 in adriamycin combined quercetin group and quercetin group was lower than that in adriamycin group.	Quercetin	144-153	immunoglobulin heavy variable 1-84	Mus musculus	79-87
31418363-9	2019	The results of transcriptome sequencing analysis showed that the expression of Ighv1-84 and Igkv6-14 in adriamycin combined quercetin group and quercetin group was lower than that in adriamycin group.	Quercetin	144-153	immunoglobulin kappa variable 6-14	Mus musculus	92-100
31366075-1	2019	The aim of this study was to estimate the mode of thyroid peroxidase (TPO) inhibition by polyphenols: Chlorogenic acid, rosmarinic acid, quercetin, and rutin.	Quercetin	137-146	thyroid peroxidase	Homo sapiens	70-73
30972796-5	2019	With 100 mumol/L HSP70 inhibitor quercetin as positive control and dimethyl sulphoxide (DMSO) as solvent control, the protein expressions of HSP70, apoptotic protease activating factor-1 (Apaf-1) and AIF were detected by Western blot.	Quercetin	33-42	apoptotic peptidase activating factor 1	Homo sapiens	148-186
31528215-0	2019	Combination of quercetin and cisplatin enhances apoptosis in OSCC cells by downregulating xIAP through the NF-kappaB pathway.	Quercetin	15-24	X-linked inhibitor of apoptosis	Homo sapiens	90-94
31528215-5	2019	Pretreatment of cancer cells with quercetin inhibited the phosphorylation Akt and IKKbeta, and led to the suppression of NF-kappaB and anti-apoptotic protein xIAP.	Quercetin	34-43	AKT serine/threonine kinase 1	Homo sapiens	74-77
31528215-5	2019	Pretreatment of cancer cells with quercetin inhibited the phosphorylation Akt and IKKbeta, and led to the suppression of NF-kappaB and anti-apoptotic protein xIAP.	Quercetin	34-43	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	82-89
31528215-5	2019	Pretreatment of cancer cells with quercetin inhibited the phosphorylation Akt and IKKbeta, and led to the suppression of NF-kappaB and anti-apoptotic protein xIAP.	Quercetin	34-43	X-linked inhibitor of apoptosis	Homo sapiens	158-162
31528215-6	2019	In addition, we observed that the pretreatment of cancer cells with quercetin improves extrinsic and intrinsic apoptosis by activating caspase-8 and caspase-9, respectively.	Quercetin	68-77	caspase 8	Homo sapiens	135-144
31528215-6	2019	In addition, we observed that the pretreatment of cancer cells with quercetin improves extrinsic and intrinsic apoptosis by activating caspase-8 and caspase-9, respectively.	Quercetin	68-77	caspase 9	Homo sapiens	149-158
30508396-6	2019	The combination of dasatinib and quercetin, compounds known to eliminate senescent cells (senolytics), reduced the number of hyperoxia-exposed beta-galactosidase-, p21-, p16-, and p-gammaH2A.X-positive ASM cells.	Quercetin	33-42	galactosidase beta 1	Homo sapiens	143-161
30508396-6	2019	The combination of dasatinib and quercetin, compounds known to eliminate senescent cells (senolytics), reduced the number of hyperoxia-exposed beta-galactosidase-, p21-, p16-, and p-gammaH2A.X-positive ASM cells.	Quercetin	33-42	H3 histone pseudogene 16	Homo sapiens	164-167
30508396-6	2019	The combination of dasatinib and quercetin, compounds known to eliminate senescent cells (senolytics), reduced the number of hyperoxia-exposed beta-galactosidase-, p21-, p16-, and p-gammaH2A.X-positive ASM cells.	Quercetin	33-42	cyclin dependent kinase inhibitor 2A	Homo sapiens	170-173
31332539-4	2019	Potential of mean force (PMF) calculations on quercetin in both CER2 and menthol-involved CER2 bilayers have been performed.	Quercetin	46-55	DAN domain BMP antagonist family member 5	Homo sapiens	64-68
31332539-4	2019	Potential of mean force (PMF) calculations on quercetin in both CER2 and menthol-involved CER2 bilayers have been performed.	Quercetin	46-55	DAN domain BMP antagonist family member 5	Homo sapiens	90-94
31092742-10	2019	We detected the alleviation of MCAO-induced the decrease in PP2A subunit B by quercetin treatment using a proteomic approach.	Quercetin	78-87	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	60-64
31092742-15	2019	We clearly showed that quercetin performs a neuroprotective function and modulates down-regulation of PP2A subunit B against MCAO injury and glutamate toxicity.	Quercetin	23-32	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	102-106
31092742-16	2019	Thus, our finding suggests that the regulation of PP2A subunit B by quercetin contributes to neuroprotective function in ischemic brain injury.	Quercetin	68-77	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	50-54
30972796-9	2019	Compared with control and DMSO groups, the expression of HSP70 protein significantly decreased, and those of Apaf-1, caspase-3 and AIF significantly increased following treatment with DHA and quercetin for 48 hr.	Quercetin	192-201	heat shock protein family A (Hsp70) member 4	Homo sapiens	57-62
30972796-9	2019	Compared with control and DMSO groups, the expression of HSP70 protein significantly decreased, and those of Apaf-1, caspase-3 and AIF significantly increased following treatment with DHA and quercetin for 48 hr.	Quercetin	192-201	apoptotic peptidase activating factor 1	Homo sapiens	109-115
30972796-9	2019	Compared with control and DMSO groups, the expression of HSP70 protein significantly decreased, and those of Apaf-1, caspase-3 and AIF significantly increased following treatment with DHA and quercetin for 48 hr.	Quercetin	192-201	caspase 3	Homo sapiens	117-126
31059754-2	2019	In this current study, the antioxidant activity of quercetin and myricetin loaded chitosan nanoparticles during the induced oxidation of Ribonuclease A (RNase A) has been compared with the corresponding free flavonoids.	Quercetin	51-60	ribonuclease A family member 1, pancreatic	Homo sapiens	137-151
31059754-2	2019	In this current study, the antioxidant activity of quercetin and myricetin loaded chitosan nanoparticles during the induced oxidation of Ribonuclease A (RNase A) has been compared with the corresponding free flavonoids.	Quercetin	51-60	ribonuclease A family member 1, pancreatic	Homo sapiens	153-160
31094081-0	2019	Quercetin protects rats from catheter-related Staphylococcus aureus infections by inhibiting coagulase activity.	Quercetin	0-9	AT695_RS02730	Staphylococcus aureus	93-102
31391723-1	2019	The present study was carried out to evaluate the in vitro cytoprotective effects of Psidium guajava and their isolated quercetin fraction to reduce the CCl4 (carbon tetrachloride) induced toxicity in HepG2 cell lines (Hepatocellular carcinoma G2).	Quercetin	120-129	C-C motif chemokine ligand 4	Homo sapiens	153-157
31391723-7	2019	The results of the present study suggest that the ethanolic extract of P. guajava leaf and their isolated quercetin fractions can able to reduce the CCl4-induced cytotoxicity in HepG2 cell lines.	Quercetin	106-115	C-C motif chemokine ligand 4	Homo sapiens	149-153
30296804-7	2019	Administration of quercetin (25 mg/kg per orally (p.o) reversed these times in MFST and TST.	Quercetin	18-27	thiosulfate sulfurtransferase, mitochondrial	Mus musculus	88-91
30478904-5	2019	We detected that quercetin and curcumin dose-dependently enhanced the BRCA1 expression.	Quercetin	17-26	BRCA1 DNA repair associated	Homo sapiens	70-75
30478904-6	2019	Further, a synergistic action of quercetin and curcumin was observed in modulating the BRCA1 level and in inhibiting the cell survival and migration of TNBC cell lines.	Quercetin	33-42	BRCA1 DNA repair associated	Homo sapiens	87-92
30478904-7	2019	Quercetin and curcumin appeared to induce BRCA1 promoter histone acetylation.	Quercetin	0-9	BRCA1 DNA repair associated	Homo sapiens	42-47
30478904-8	2019	Furthermore, BRCA1 knockdown induced cell survival and cell migration in ER + cells were significantly decreased by the combined treatment of quercetin and curcumin.	Quercetin	142-151	BRCA1 DNA repair associated	Homo sapiens	13-18
31094081-3	2019	Here, we found that quercetin, a natural compound that does not affect S aureus viability, could inhibit Coa activity.	Quercetin	20-29	AT695_RS02730	Staphylococcus aureus	105-108
31094081-4	2019	Chemical biological analysis revealed that the direct engagement of quercetin with the active site (residues Tyr187, Leu221 and His228) of Coa inhibited its activity.	Quercetin	68-77	AT695_RS02730	Staphylococcus aureus	139-142
31094081-6	2019	These data suggest that antiinfective therapy targeting Coa with quercetin may represent a novel strategy and provide a new leading compound with which to combat bacterial infections.	Quercetin	65-74	AT695_RS02730	Staphylococcus aureus	56-59
31096072-3	2019	In 3 T3-L1 preadipocytes, Quercetin and Q2 treatment induce chromatin remodeling and histone modifications at the 5" regulatory region of the two main adipogenic genes, c/EBPalpha and PPARgamma.	Quercetin	26-35	CCAAT/enhancer binding protein alpha	Rattus norvegicus	169-179
30920336-8	2019	Quercetin treatment also significantly reduced colonic expression of Ngn3 and pdx1 of PI-IBS.	Quercetin	0-9	neurogenin 3	Rattus norvegicus	69-73
30920336-8	2019	Quercetin treatment also significantly reduced colonic expression of Ngn3 and pdx1 of PI-IBS.	Quercetin	0-9	pancreatic and duodenal homeobox 1	Rattus norvegicus	78-82
31096072-3	2019	In 3 T3-L1 preadipocytes, Quercetin and Q2 treatment induce chromatin remodeling and histone modifications at the 5" regulatory region of the two main adipogenic genes, c/EBPalpha and PPARgamma.	Quercetin	26-35	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	184-193
31261749-6	2019	The anti-cancer effects of quercetin include its ability to promote the loss of cell viability, apoptosis and autophagy through the modulation of PI3K/Akt/mTOR, Wnt/-catenin, and MAPK/ERK1/2 pathways.	Quercetin	27-36	AKT serine/threonine kinase 1	Homo sapiens	151-154
31251771-7	2019	Quercetin prophylaxis significantly down regulated hypoxia induced increase in IKKalpha/beta and NFkB expressions leading to reduction in the levels of pro-inflammatory cytokines (TNF-alpha and INF-gamma) followed by up regulation of anti-inflammatory cytokines (IL-4 and INF-gamma) in lungs.	Quercetin	0-9	inhibitor of nuclear factor kappa B kinase subunit beta	Rattus norvegicus	79-92
31261749-6	2019	The anti-cancer effects of quercetin include its ability to promote the loss of cell viability, apoptosis and autophagy through the modulation of PI3K/Akt/mTOR, Wnt/-catenin, and MAPK/ERK1/2 pathways.	Quercetin	27-36	mechanistic target of rapamycin kinase	Homo sapiens	155-159
31251771-7	2019	Quercetin prophylaxis significantly down regulated hypoxia induced increase in IKKalpha/beta and NFkB expressions leading to reduction in the levels of pro-inflammatory cytokines (TNF-alpha and INF-gamma) followed by up regulation of anti-inflammatory cytokines (IL-4 and INF-gamma) in lungs.	Quercetin	0-9	nuclear factor kappa B subunit 1	Rattus norvegicus	97-101
31251771-7	2019	Quercetin prophylaxis significantly down regulated hypoxia induced increase in IKKalpha/beta and NFkB expressions leading to reduction in the levels of pro-inflammatory cytokines (TNF-alpha and INF-gamma) followed by up regulation of anti-inflammatory cytokines (IL-4 and INF-gamma) in lungs.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	180-189
31251771-7	2019	Quercetin prophylaxis significantly down regulated hypoxia induced increase in IKKalpha/beta and NFkB expressions leading to reduction in the levels of pro-inflammatory cytokines (TNF-alpha and INF-gamma) followed by up regulation of anti-inflammatory cytokines (IL-4 and INF-gamma) in lungs.	Quercetin	0-9	interleukin 4	Rattus norvegicus	263-281
31251771-8	2019	Further, hypoxia mediated increase in HIF-1alpha was stabilized and VEGF levels in lungs were significantly down regulated by quercetin supplementation, leading to reduction in vascular leakage in lungs of rats under hypoxia.	Quercetin	126-135	vascular endothelial growth factor A	Rattus norvegicus	68-72
31251771-9	2019	However, Quercetin has also enacted as Nrf-2 activator which significantly boosted up the synthesis of GSH under hypoxic condition compared to hypoxia.	Quercetin	9-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	39-44
31251771-10	2019	Histopathological observations further confirmed that quercetin preconditioning has an inhibitory effect on progression of oxidative stress and inflammation via attenuation of NFkappaB and stabilization HIF-1alpha in lungs of rats under hypoxia.These studies indicated that quercetin prophylaxis abrogates the possibility of hypobaric hypoxia induced pulmonary edema in rats.	Quercetin	54-63	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	203-213
31261749-6	2019	The anti-cancer effects of quercetin include its ability to promote the loss of cell viability, apoptosis and autophagy through the modulation of PI3K/Akt/mTOR, Wnt/-catenin, and MAPK/ERK1/2 pathways.	Quercetin	27-36	mitogen-activated protein kinase 3	Homo sapiens	179-183
31261749-6	2019	The anti-cancer effects of quercetin include its ability to promote the loss of cell viability, apoptosis and autophagy through the modulation of PI3K/Akt/mTOR, Wnt/-catenin, and MAPK/ERK1/2 pathways.	Quercetin	27-36	mitogen-activated protein kinase 3	Homo sapiens	184-190
31248028-7	2019	The linearity (R2 = 0.9999) of the proposed analytical procedure for quercetin determination in positive ions was provided in the range between 10-4 M and 10-7 M. Moreover, the same parameters were established for FAPA-MS in positive ions, reaching LOD at 0.005 mg/gMIP and the linearity of the method in the range of 0.015-0.075 mg/gMIP with the correlation coefficient value R2 = 0.9850.	Quercetin	69-78	GEM interacting protein	Homo sapiens	265-269
31248028-7	2019	The linearity (R2 = 0.9999) of the proposed analytical procedure for quercetin determination in positive ions was provided in the range between 10-4 M and 10-7 M. Moreover, the same parameters were established for FAPA-MS in positive ions, reaching LOD at 0.005 mg/gMIP and the linearity of the method in the range of 0.015-0.075 mg/gMIP with the correlation coefficient value R2 = 0.9850.	Quercetin	69-78	GEM interacting protein	Homo sapiens	333-337
31180394-5	2019	Quercetin reduced the TGF-beta1 expression and inhibited the epithelial cell to mesenchymal cell phenotypic switch, as well as ECM deposition in rats with UUO.	Quercetin	0-9	transforming growth factor, beta 1	Rattus norvegicus	22-31
31086922-8	2019	Regarding other bioactive compounds, chia seeds are also a source of antioxidants, such as chlorogenic and caffeic acids, quercetin and kaempferol.	Quercetin	122-131	chitinase acidic	Homo sapiens	37-41
31155811-9	2019	The presentstudy results revealed that quercetin might be inhibited the CYP2E1-mediated metabolism of paracetamol; thereby decreased the formation of NAPQI and protected the liver and kidney.	Quercetin	39-48	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	72-78
31180394-6	2019	In cultured epithelial cells of the renal tubular region (NRK-52E), quercetin markedly ameliorated the EMT and ECM synthesis induced by TGF-beta1.	Quercetin	68-77	transforming growth factor, beta 1	Rattus norvegicus	136-145
31180394-8	2019	Quercetin effectively suppressed the hyperactive Hedgehog pathway in NRK-52E cells treated with TGF-beta1 and in kidney obstructed rats, which reduced the EMT, ECM deposition and cellular proliferation.	Quercetin	0-9	transforming growth factor, beta 1	Rattus norvegicus	96-105
31180394-10	2019	The results unveiled that the four transcriptional factors were highly repressed in NRK-52E cells treated with TGF-beta1 and also in obstructed kidneys by quercetin-mediated inhibition.	Quercetin	155-164	transforming growth factor, beta 1	Rattus norvegicus	111-120
31212975-11	2019	Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response.	Quercetin	52-61	interleukin 1 alpha	Homo sapiens	94-102
31212975-11	2019	Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response.	Quercetin	52-61	intercellular adhesion molecule 1	Homo sapiens	126-132
31212975-0	2019	Quercetin Inhibits the Production of IL-1beta-Induced Inflammatory Cytokines and Chemokines in ARPE-19 Cells via the MAPK and NF-kappaB Signaling Pathways.	Quercetin	0-9	interleukin 1 alpha	Homo sapiens	37-45
31212975-11	2019	Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response.	Quercetin	52-61	interleukin 6	Homo sapiens	143-147
31212975-2	2019	Our previous study revealed that quercetin could suppress the expression of matrix metalloprotease-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1) to achieve anti-inflammatory effects in tumor necrosis factor-alpha (TNF-alpha)-stimulated human retinal pigment epithelial (ARPE-19) cells.	Quercetin	33-42	matrix metallopeptidase 9	Homo sapiens	76-100
31212975-2	2019	Our previous study revealed that quercetin could suppress the expression of matrix metalloprotease-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1) to achieve anti-inflammatory effects in tumor necrosis factor-alpha (TNF-alpha)-stimulated human retinal pigment epithelial (ARPE-19) cells.	Quercetin	33-42	matrix metallopeptidase 9	Homo sapiens	102-107
31212975-11	2019	Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response.	Quercetin	52-61	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
31212975-2	2019	Our previous study revealed that quercetin could suppress the expression of matrix metalloprotease-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1) to achieve anti-inflammatory effects in tumor necrosis factor-alpha (TNF-alpha)-stimulated human retinal pigment epithelial (ARPE-19) cells.	Quercetin	33-42	intercellular adhesion molecule 1	Homo sapiens	113-146
31212975-2	2019	Our previous study revealed that quercetin could suppress the expression of matrix metalloprotease-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1) to achieve anti-inflammatory effects in tumor necrosis factor-alpha (TNF-alpha)-stimulated human retinal pigment epithelial (ARPE-19) cells.	Quercetin	33-42	intercellular adhesion molecule 1	Homo sapiens	148-154
31212975-2	2019	Our previous study revealed that quercetin could suppress the expression of matrix metalloprotease-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1) to achieve anti-inflammatory effects in tumor necrosis factor-alpha (TNF-alpha)-stimulated human retinal pigment epithelial (ARPE-19) cells.	Quercetin	33-42	tumor necrosis factor	Homo sapiens	196-223
31212975-2	2019	Our previous study revealed that quercetin could suppress the expression of matrix metalloprotease-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1) to achieve anti-inflammatory effects in tumor necrosis factor-alpha (TNF-alpha)-stimulated human retinal pigment epithelial (ARPE-19) cells.	Quercetin	33-42	tumor necrosis factor	Homo sapiens	225-234
31212975-3	2019	The present study explored whether quercetin can inhibit the interleukin-1beta (IL-1beta)-induced production of inflammatory cytokines and chemokines in ARPE-19 cells.	Quercetin	35-44	interleukin 1 beta	Homo sapiens	61-78
31212975-3	2019	The present study explored whether quercetin can inhibit the interleukin-1beta (IL-1beta)-induced production of inflammatory cytokines and chemokines in ARPE-19 cells.	Quercetin	35-44	interleukin 1 alpha	Homo sapiens	80-88
31212975-5	2019	The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1).	Quercetin	24-33	intercellular adhesion molecule 1	Homo sapiens	97-103
31212975-5	2019	The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1).	Quercetin	24-33	interleukin 6	Homo sapiens	105-109
31212975-5	2019	The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1).	Quercetin	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
31212975-11	2019	Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response.	Quercetin	52-61	C-C motif chemokine ligand 2	Homo sapiens	158-163
31212975-5	2019	The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1).	Quercetin	24-33	C-C motif chemokine ligand 2	Homo sapiens	120-154
31212975-5	2019	The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1).	Quercetin	24-33	C-C motif chemokine ligand 2	Homo sapiens	156-161
30958996-0	2019	Quercetin enhances the antitumor activity of trichostatin A through up-regulation of p300 protein expression in p53 null cancer cells.	Quercetin	0-9	E1A binding protein p300	Homo sapiens	85-89
31212975-7	2019	We also demonstrated that quercetin inhibited signaling pathways related to the inflammatory process, including phosphorylation of mitogen-activated protein kinases (MAPKs), inhibitor of nuclear factor kappa-B kinase (IKK)alpha/beta, c-Jun, cAMP response element-binding protein (CREB), activating transcription factor 2 (ATF2) and nuclear factor (NF)-kappaB p65, and blocked the translocation of NF-kappaB p65 into the nucleus.	Quercetin	26-35	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	218-232
31212975-7	2019	We also demonstrated that quercetin inhibited signaling pathways related to the inflammatory process, including phosphorylation of mitogen-activated protein kinases (MAPKs), inhibitor of nuclear factor kappa-B kinase (IKK)alpha/beta, c-Jun, cAMP response element-binding protein (CREB), activating transcription factor 2 (ATF2) and nuclear factor (NF)-kappaB p65, and blocked the translocation of NF-kappaB p65 into the nucleus.	Quercetin	26-35	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	234-239
31212975-7	2019	We also demonstrated that quercetin inhibited signaling pathways related to the inflammatory process, including phosphorylation of mitogen-activated protein kinases (MAPKs), inhibitor of nuclear factor kappa-B kinase (IKK)alpha/beta, c-Jun, cAMP response element-binding protein (CREB), activating transcription factor 2 (ATF2) and nuclear factor (NF)-kappaB p65, and blocked the translocation of NF-kappaB p65 into the nucleus.	Quercetin	26-35	cAMP responsive element binding protein 1	Homo sapiens	241-278
31212975-7	2019	We also demonstrated that quercetin inhibited signaling pathways related to the inflammatory process, including phosphorylation of mitogen-activated protein kinases (MAPKs), inhibitor of nuclear factor kappa-B kinase (IKK)alpha/beta, c-Jun, cAMP response element-binding protein (CREB), activating transcription factor 2 (ATF2) and nuclear factor (NF)-kappaB p65, and blocked the translocation of NF-kappaB p65 into the nucleus.	Quercetin	26-35	cAMP responsive element binding protein 1	Homo sapiens	280-284
31212975-7	2019	We also demonstrated that quercetin inhibited signaling pathways related to the inflammatory process, including phosphorylation of mitogen-activated protein kinases (MAPKs), inhibitor of nuclear factor kappa-B kinase (IKK)alpha/beta, c-Jun, cAMP response element-binding protein (CREB), activating transcription factor 2 (ATF2) and nuclear factor (NF)-kappaB p65, and blocked the translocation of NF-kappaB p65 into the nucleus.	Quercetin	26-35	activating transcription factor 2	Homo sapiens	287-320
31212975-7	2019	We also demonstrated that quercetin inhibited signaling pathways related to the inflammatory process, including phosphorylation of mitogen-activated protein kinases (MAPKs), inhibitor of nuclear factor kappa-B kinase (IKK)alpha/beta, c-Jun, cAMP response element-binding protein (CREB), activating transcription factor 2 (ATF2) and nuclear factor (NF)-kappaB p65, and blocked the translocation of NF-kappaB p65 into the nucleus.	Quercetin	26-35	activating transcription factor 2	Homo sapiens	322-326
31212975-7	2019	We also demonstrated that quercetin inhibited signaling pathways related to the inflammatory process, including phosphorylation of mitogen-activated protein kinases (MAPKs), inhibitor of nuclear factor kappa-B kinase (IKK)alpha/beta, c-Jun, cAMP response element-binding protein (CREB), activating transcription factor 2 (ATF2) and nuclear factor (NF)-kappaB p65, and blocked the translocation of NF-kappaB p65 into the nucleus.	Quercetin	26-35	RELA proto-oncogene, NF-kB subunit	Homo sapiens	332-362
31212975-7	2019	We also demonstrated that quercetin inhibited signaling pathways related to the inflammatory process, including phosphorylation of mitogen-activated protein kinases (MAPKs), inhibitor of nuclear factor kappa-B kinase (IKK)alpha/beta, c-Jun, cAMP response element-binding protein (CREB), activating transcription factor 2 (ATF2) and nuclear factor (NF)-kappaB p65, and blocked the translocation of NF-kappaB p65 into the nucleus.	Quercetin	26-35	RELA proto-oncogene, NF-kB subunit	Homo sapiens	397-410
30981564-5	2019	Treatments with quercetin reduced PCNA and bax accumulation and decreased P4 release from both granulosa cells of pigs and cattle.	Quercetin	16-25	proliferating cell nuclear antigen	Sus scrofa	34-38
30981564-5	2019	Treatments with quercetin reduced PCNA and bax accumulation and decreased P4 release from both granulosa cells of pigs and cattle.	Quercetin	16-25	apoptosis regulator BAX	Sus scrofa	43-46
30981564-7	2019	In cells of pigs, quercetin reduced IGF-I release.	Quercetin	18-27	insulin like growth factor 1	Sus scrofa	36-41
30981564-8	2019	In cells of cattle, quercetin at smaller doses (1 or 10 ng/mL), promoted and at a large dose (100 ng/mL) reduced IGF-I secretions.	Quercetin	20-29	IGFI	Bos taurus	113-118
30978523-0	2019	Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1.	Quercetin	0-9	parathyroid hormone 1 receptor	Homo sapiens	101-131
30978523-3	2019	In the present study, we evaluated the effects of quercetin-induced inhibition of parathyroid hormone receptor 1 (PTHR1) on proliferation, migration, and invasion in U2OS and Saos-2 cells.	Quercetin	50-59	parathyroid hormone 1 receptor	Homo sapiens	82-112
30978523-3	2019	In the present study, we evaluated the effects of quercetin-induced inhibition of parathyroid hormone receptor 1 (PTHR1) on proliferation, migration, and invasion in U2OS and Saos-2 cells.	Quercetin	50-59	parathyroid hormone 1 receptor	Homo sapiens	114-119
30978523-4	2019	Following incubation with quercetin (20, 40, 60, 80, or 100 muM) for 48 h, the cell viability of U2OS and Saos-2 cells were significantly reduced in a dose-dependent manner.	Quercetin	26-35	latexin	Homo sapiens	60-63
30978523-7	2019	Quercetin treatment also significantly reduced the mRNA expression levels of PTHR1 by 0.27-, and 0.55-fold at 80, and 100 muM, respectively, whereas 0.19 and 0.41 folds in Saos-2 cells.	Quercetin	0-9	parathyroid hormone 1 receptor	Homo sapiens	77-82
30978523-7	2019	Quercetin treatment also significantly reduced the mRNA expression levels of PTHR1 by 0.27-, and 0.55-fold at 80, and 100 muM, respectively, whereas 0.19 and 0.41 folds in Saos-2 cells.	Quercetin	0-9	latexin	Homo sapiens	122-125
30978523-8	2019	PTHR1 protein expression in U2OS cells was reduced by 0.19-, and 0.43-fold at 80, and 100 muM of quercetin, respectively (P &lt; 0.05), whereas 0.17 and 0.35 folds in Saos-2 cells.	Quercetin	97-106	parathyroid hormone 1 receptor	Homo sapiens	0-5
30978523-9	2019	Immunofluorescence analyses revealed reduced expression of PTHR1 following treatment with quercetin.	Quercetin	90-99	parathyroid hormone 1 receptor	Homo sapiens	59-64
30978523-11	2019	The knockdown of PTHR1enhanced quercetin-inhibited proliferation and invasion.	Quercetin	31-40	parathyroid hormone 1 receptor	Homo sapiens	17-22
30978523-12	2019	Taken together, the present findings indicate that quercetin reduced human metastatic osteosarcoma cell invasion, adhesion, proliferation, and migration by inhibiting PTHR1.	Quercetin	51-60	parathyroid hormone 1 receptor	Homo sapiens	167-172
31195662-6	2019	We propose that targeting ISR signaling with quercetin has therapeutic potential, because it suppresses amyloid-beta (Abeta) production in vitro and prevents cognitive impairments in a mouse model of AD.	Quercetin	45-54	amyloid beta (A4) precursor protein	Mus musculus	118-123
31281594-6	2019	However, under subchronic hepatotoxicity, quercetin decreased the significant increase in SIRT1 expression to lower levels which are still higher than normal ones and mitigated the liver-damaging effects of carbon tetrachloride.	Quercetin	42-51	sirtuin 1	Rattus norvegicus	90-95
30991286-9	2019	Moreover, in vitro experiments showed that rhein, kaempferol and quercetin treatments remarkably decreased the protein levels of cleaved caspase-3 and increased p-ERK1/2, PI3K and Bcl-XL protein expression in TNF-alpha-stimulated L02 cells.	Quercetin	65-74	mitogen-activated protein kinase 3	Homo sapiens	163-169
30991286-9	2019	Moreover, in vitro experiments showed that rhein, kaempferol and quercetin treatments remarkably decreased the protein levels of cleaved caspase-3 and increased p-ERK1/2, PI3K and Bcl-XL protein expression in TNF-alpha-stimulated L02 cells.	Quercetin	65-74	BCL2 like 1	Homo sapiens	180-186
30991286-9	2019	Moreover, in vitro experiments showed that rhein, kaempferol and quercetin treatments remarkably decreased the protein levels of cleaved caspase-3 and increased p-ERK1/2, PI3K and Bcl-XL protein expression in TNF-alpha-stimulated L02 cells.	Quercetin	65-74	tumor necrosis factor	Homo sapiens	209-218
30991286-10	2019	On the contrary, rhein, kaempferol, aloe-emodin and quercetin inhibited the proliferation of LX2 cells and up-regulated the protein levels of Bax and cleaved caspase-8.	Quercetin	52-61	BCL2 associated X, apoptosis regulator	Homo sapiens	142-145
30991286-10	2019	On the contrary, rhein, kaempferol, aloe-emodin and quercetin inhibited the proliferation of LX2 cells and up-regulated the protein levels of Bax and cleaved caspase-8.	Quercetin	52-61	caspase 8	Homo sapiens	158-167
31243677-6	2019	Addition of quercetin to the ration (experimental group 2) led to a decrease in the expression of Khk, Gck, Fasn, Scd, Mlxipl, and Ppara genes in comparison with experimental group 1.	Quercetin	12-21	ketohexokinase	Rattus norvegicus	98-101
31243677-6	2019	Addition of quercetin to the ration (experimental group 2) led to a decrease in the expression of Khk, Gck, Fasn, Scd, Mlxipl, and Ppara genes in comparison with experimental group 1.	Quercetin	12-21	glucokinase	Rattus norvegicus	103-106
31243677-6	2019	Addition of quercetin to the ration (experimental group 2) led to a decrease in the expression of Khk, Gck, Fasn, Scd, Mlxipl, and Ppara genes in comparison with experimental group 1.	Quercetin	12-21	fatty acid synthase	Rattus norvegicus	108-112
31243677-6	2019	Addition of quercetin to the ration (experimental group 2) led to a decrease in the expression of Khk, Gck, Fasn, Scd, Mlxipl, and Ppara genes in comparison with experimental group 1.	Quercetin	12-21	stearoyl-CoA desaturase	Rattus norvegicus	114-117
31243677-6	2019	Addition of quercetin to the ration (experimental group 2) led to a decrease in the expression of Khk, Gck, Fasn, Scd, Mlxipl, and Ppara genes in comparison with experimental group 1.	Quercetin	12-21	MLX interacting protein-like	Rattus norvegicus	119-125
31243677-6	2019	Addition of quercetin to the ration (experimental group 2) led to a decrease in the expression of Khk, Gck, Fasn, Scd, Mlxipl, and Ppara genes in comparison with experimental group 1.	Quercetin	12-21	peroxisome proliferator activated receptor alpha	Rattus norvegicus	131-136
30958996-0	2019	Quercetin enhances the antitumor activity of trichostatin A through up-regulation of p300 protein expression in p53 null cancer cells.	Quercetin	0-9	tumor protein p53	Homo sapiens	112-115
30958996-1	2019	In the present study, we investigated the p53-independent mechanism by which quercetin (Q) increased apoptosis in human lung cancer H1299 cells exposed to trichostatin A (TSA), a histone deacetylase inhibitor.	Quercetin	77-86	tumor protein p53	Homo sapiens	42-45
30870790-1	2019	Quercetin-mediated gold nanoclusters (Qu-GNCs) were prepared for the first time by employing bovine serum albumin (BSA) as a stabilizer with a natural flavonoid, "quercetin" as a reducing agent.	Quercetin	0-9	albumin	Homo sapiens	100-113
30958996-4	2019	Transfection of DR5 siRNA into H1299 cells significantly diminished the enhancing effects of Q on TSA-induced apoptosis.	Quercetin	93-94	TNF receptor superfamily member 10b	Homo sapiens	16-19
30958996-8	2019	These data suggest that the up-regulation of p300 expression, which in turn increases histone acetylation and DR5 expression, plays an important role in the enhancing effect of Q on TSA/vorinostat- induced apoptosis in H1299 cells.	Quercetin	177-178	E1A binding protein p300	Homo sapiens	45-49
30958996-8	2019	These data suggest that the up-regulation of p300 expression, which in turn increases histone acetylation and DR5 expression, plays an important role in the enhancing effect of Q on TSA/vorinostat- induced apoptosis in H1299 cells.	Quercetin	177-178	TNF receptor superfamily member 10b	Homo sapiens	110-113
31029788-0	2019	Long term treatment with quercetin in contrast to the sulfate and glucuronide conjugates affects HIF1alpha stability and Nrf2 signaling in endothelial cells and leads to changes in glucose metabolism.	Quercetin	25-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-106
30849307-0	2019	Quercetin ameliorates lipopolysaccharide-caused inflammatory damage via down-regulation of miR-221 in WI-38 cells.	Quercetin	0-9	microRNA 221	Homo sapiens	91-98
30849307-10	2019	Quercetin treatment mitigated the LPS-caused inflammatory damage of WI-38 lung fibroblasts via enhancing cell viability, inhibiting cell apoptosis and reducing the production of inflammatory cytokines IL-6 and TNF-a.	Quercetin	0-9	interleukin 6	Homo sapiens	201-205
30849307-10	2019	Quercetin treatment mitigated the LPS-caused inflammatory damage of WI-38 lung fibroblasts via enhancing cell viability, inhibiting cell apoptosis and reducing the production of inflammatory cytokines IL-6 and TNF-a.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	210-215
30849307-11	2019	Moreover, quercetin ameliorated LPS-caused up-regulation of miR-221 in WI-38.	Quercetin	10-19	microRNA 221	Homo sapiens	60-67
30849307-12	2019	The effects of quercetin on LPS-caused inflammatory damage of WI-38 were reversed by miR-221 overexpression.	Quercetin	15-24	microRNA 221	Homo sapiens	85-92
30849307-13	2019	Furthermore, quercetin inactivated NF-kappaB and JNK pathways in LPS-treated WI-38 via down-regulation of miR-221.	Quercetin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	35-44
30849307-13	2019	Furthermore, quercetin inactivated NF-kappaB and JNK pathways in LPS-treated WI-38 via down-regulation of miR-221.	Quercetin	13-22	mitogen-activated protein kinase 8	Homo sapiens	49-52
30849307-13	2019	Furthermore, quercetin inactivated NF-kappaB and JNK pathways in LPS-treated WI-38 via down-regulation of miR-221.	Quercetin	13-22	microRNA 221	Homo sapiens	106-113
30849307-15	2019	We revealed that quercetin ameliorated LPS-caused inflammatory damage of WI-38 lung fibroblasts might be through down-regulation of miR-221 and inactivation of NF-kappaB and JNK pathways.	Quercetin	17-26	microRNA 221	Homo sapiens	132-139
30849307-15	2019	We revealed that quercetin ameliorated LPS-caused inflammatory damage of WI-38 lung fibroblasts might be through down-regulation of miR-221 and inactivation of NF-kappaB and JNK pathways.	Quercetin	17-26	nuclear factor kappa B subunit 1	Homo sapiens	160-169
30849307-15	2019	We revealed that quercetin ameliorated LPS-caused inflammatory damage of WI-38 lung fibroblasts might be through down-regulation of miR-221 and inactivation of NF-kappaB and JNK pathways.	Quercetin	17-26	mitogen-activated protein kinase 8	Homo sapiens	174-177
31029788-0	2019	Long term treatment with quercetin in contrast to the sulfate and glucuronide conjugates affects HIF1alpha stability and Nrf2 signaling in endothelial cells and leads to changes in glucose metabolism.	Quercetin	25-34	NFE2 like bZIP transcription factor 2	Homo sapiens	121-125
31029788-6	2019	Heme oxygenase-1 (HO-1) was induced by quercetin but not its conjugates, but was not implicated in the glucose uptake stimulation since hemin, a classical inducer of HO-1, did not affect glucose metabolism.	Quercetin	39-48	heme oxygenase 1	Homo sapiens	0-16
31029788-6	2019	Heme oxygenase-1 (HO-1) was induced by quercetin but not its conjugates, but was not implicated in the glucose uptake stimulation since hemin, a classical inducer of HO-1, did not affect glucose metabolism.	Quercetin	39-48	heme oxygenase 1	Homo sapiens	18-22
31029788-7	2019	Quercetin increased stability of the transcription factor hypoxia induced factor 1alpha (HIF1alpha), a powerful stimulant of glucose metabolism, which was also paralleled by treatment with a prolyl-4-hydroxylase inhibitor dimethyloxalylglycine (DMOG).	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-98
31029788-8	2019	6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which regulates the rate of glycolysis, was upregulated by both quercetin and DMOG.	Quercetin	128-137	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	0-53
31029788-8	2019	6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which regulates the rate of glycolysis, was upregulated by both quercetin and DMOG.	Quercetin	128-137	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	55-61
31029788-10	2019	Quercetin, but not DMOG, increased glucose-6-phosphate dehydrogenase.	Quercetin	0-9	glucose-6-phosphate dehydrogenase	Homo sapiens	35-68
31029788-13	2019	We conclude that quercetin and its circulating metabolites differentially modulate glucose uptake/metabolism in endothelial cells, through effects on HIF1alpha and transcriptional regulation of energy metabolism.	Quercetin	17-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	150-159
30656723-0	2019	Quercetin improve ischemia/reperfusion-induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC-1alpha signaling.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	102-107
30656723-0	2019	Quercetin improve ischemia/reperfusion-induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC-1alpha signaling.	Quercetin	0-9	PPARG coactivator 1 alpha	Rattus norvegicus	108-118
30656723-5	2019	The silent information regulatory factor 1 (SIRT1), peroxisome proliferators-activated receptor-gamma coactivator-1alpha (PGC-1alpha), and Bcl-2 proteins expression of quercetin treated were significantly upregulation compared with MC group (P &lt; 0.05, respectively), and Bax protein expression of quercetin treated group was significantly downregulation compared with MC group ( P &lt; 0.05, respectively).	Quercetin	168-177	sirtuin 1	Rattus norvegicus	4-42
30656723-5	2019	The silent information regulatory factor 1 (SIRT1), peroxisome proliferators-activated receptor-gamma coactivator-1alpha (PGC-1alpha), and Bcl-2 proteins expression of quercetin treated were significantly upregulation compared with MC group (P &lt; 0.05, respectively), and Bax protein expression of quercetin treated group was significantly downregulation compared with MC group ( P &lt; 0.05, respectively).	Quercetin	168-177	sirtuin 1	Rattus norvegicus	44-49
30656723-5	2019	The silent information regulatory factor 1 (SIRT1), peroxisome proliferators-activated receptor-gamma coactivator-1alpha (PGC-1alpha), and Bcl-2 proteins expression of quercetin treated were significantly upregulation compared with MC group (P &lt; 0.05, respectively), and Bax protein expression of quercetin treated group was significantly downregulation compared with MC group ( P &lt; 0.05, respectively).	Quercetin	168-177	PPARG coactivator 1 alpha	Rattus norvegicus	122-132
30656723-5	2019	The silent information regulatory factor 1 (SIRT1), peroxisome proliferators-activated receptor-gamma coactivator-1alpha (PGC-1alpha), and Bcl-2 proteins expression of quercetin treated were significantly upregulation compared with MC group (P &lt; 0.05, respectively), and Bax protein expression of quercetin treated group was significantly downregulation compared with MC group ( P &lt; 0.05, respectively).	Quercetin	168-177	BCL2, apoptosis regulator	Rattus norvegicus	139-144
30656723-5	2019	The silent information regulatory factor 1 (SIRT1), peroxisome proliferators-activated receptor-gamma coactivator-1alpha (PGC-1alpha), and Bcl-2 proteins expression of quercetin treated were significantly upregulation compared with MC group (P &lt; 0.05, respectively), and Bax protein expression of quercetin treated group was significantly downregulation compared with MC group ( P &lt; 0.05, respectively).	Quercetin	168-177	BCL2 associated X, apoptosis regulator	Rattus norvegicus	274-277
30656723-8	2019	SIRT1, PGC-1a, Bcl-2, and Bax proteins expressions of quercetin treated groups were significant differences compared with MC group in myocardial tissue ( P &lt; 0.05, respectively).	Quercetin	54-63	sirtuin 1	Rattus norvegicus	0-5
30656723-8	2019	SIRT1, PGC-1a, Bcl-2, and Bax proteins expressions of quercetin treated groups were significant differences compared with MC group in myocardial tissue ( P &lt; 0.05, respectively).	Quercetin	54-63	PPARG coactivator 1 alpha	Rattus norvegicus	7-13
30656723-8	2019	SIRT1, PGC-1a, Bcl-2, and Bax proteins expressions of quercetin treated groups were significant differences compared with MC group in myocardial tissue ( P &lt; 0.05, respectively).	Quercetin	54-63	BCL2, apoptosis regulator	Rattus norvegicus	15-20
30656723-8	2019	SIRT1, PGC-1a, Bcl-2, and Bax proteins expressions of quercetin treated groups were significant differences compared with MC group in myocardial tissue ( P &lt; 0.05, respectively).	Quercetin	54-63	BCL2 associated X, apoptosis regulator	Rattus norvegicus	26-29
30656723-9	2019	CONCLUSION: Quercetin had improved the myocardial ischemia/reperfusion-induced cardiomyocyte apoptosis via SIRT1/PGC-1alpha signaling.	Quercetin	12-21	sirtuin 1	Rattus norvegicus	107-112
30656723-9	2019	CONCLUSION: Quercetin had improved the myocardial ischemia/reperfusion-induced cardiomyocyte apoptosis via SIRT1/PGC-1alpha signaling.	Quercetin	12-21	PPARG coactivator 1 alpha	Rattus norvegicus	113-123
30878575-5	2019	Hesperidin and quercetin treatment resulted in decreased levels of TNF-alpha and increased levels of IL-10.	Quercetin	15-24	tumor necrosis factor	Rattus norvegicus	67-76
31257059-0	2019	Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22/WNT1/beta-catenin axis.	Quercetin	0-9	microRNA 22	Homo sapiens	85-96
31257059-0	2019	Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22/WNT1/beta-catenin axis.	Quercetin	0-9	Wnt family member 1	Homo sapiens	97-101
31257059-0	2019	Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22/WNT1/beta-catenin axis.	Quercetin	0-9	catenin beta 1	Homo sapiens	102-114
31257059-2	2019	Moreover, the anti-tumor effect of quercetin is correlated with WNT/beta-catenin pathway and miRNA dysregulation.	Quercetin	35-44	catenin beta 1	Homo sapiens	68-80
31257059-3	2019	In the present study, we aimed to further investigate whether quercetin can exert its anti-tumor function by regulating miR-22 together with miR-22 downstream pathway WNT1/beta-catenin in OSCC.	Quercetin	62-71	microRNA 22	Homo sapiens	120-126
31257059-3	2019	In the present study, we aimed to further investigate whether quercetin can exert its anti-tumor function by regulating miR-22 together with miR-22 downstream pathway WNT1/beta-catenin in OSCC.	Quercetin	62-71	microRNA 22	Homo sapiens	141-147
31257059-3	2019	In the present study, we aimed to further investigate whether quercetin can exert its anti-tumor function by regulating miR-22 together with miR-22 downstream pathway WNT1/beta-catenin in OSCC.	Quercetin	62-71	Wnt family member 1	Homo sapiens	167-171
31257059-3	2019	In the present study, we aimed to further investigate whether quercetin can exert its anti-tumor function by regulating miR-22 together with miR-22 downstream pathway WNT1/beta-catenin in OSCC.	Quercetin	62-71	catenin beta 1	Homo sapiens	172-184
31257059-6	2019	RT-qPCR assay showed that quercetin promoted miR-22 expression and suppressed WNT1 and beta-catenin expression in OSCC cells, whereas this effect was abrogated by miR-22 inhibitor.	Quercetin	26-35	microRNA 22	Homo sapiens	45-51
31257059-6	2019	RT-qPCR assay showed that quercetin promoted miR-22 expression and suppressed WNT1 and beta-catenin expression in OSCC cells, whereas this effect was abrogated by miR-22 inhibitor.	Quercetin	26-35	Wnt family member 1	Homo sapiens	78-82
31257059-6	2019	RT-qPCR assay showed that quercetin promoted miR-22 expression and suppressed WNT1 and beta-catenin expression in OSCC cells, whereas this effect was abrogated by miR-22 inhibitor.	Quercetin	26-35	catenin beta 1	Homo sapiens	87-99
31257059-6	2019	RT-qPCR assay showed that quercetin promoted miR-22 expression and suppressed WNT1 and beta-catenin expression in OSCC cells, whereas this effect was abrogated by miR-22 inhibitor.	Quercetin	26-35	microRNA 22	Homo sapiens	163-169
31257059-7	2019	Moreover, miR-22 depletion weakened quercetin-mediated viability inhibition and apoptosis increase in OSCC cells.	Quercetin	36-45	microRNA 22	Homo sapiens	10-16
31257059-8	2019	Quercetin inhibited the growth of OSCC xenograft tumors by inducing miR-22 expression and repressing WNT1/beta-catenin pathway in vivo.	Quercetin	0-9	microRNA 22	Homo sapiens	68-74
31257059-8	2019	Quercetin inhibited the growth of OSCC xenograft tumors by inducing miR-22 expression and repressing WNT1/beta-catenin pathway in vivo.	Quercetin	0-9	Wnt family member 1	Homo sapiens	101-105
31257059-8	2019	Quercetin inhibited the growth of OSCC xenograft tumors by inducing miR-22 expression and repressing WNT1/beta-catenin pathway in vivo.	Quercetin	0-9	catenin beta 1	Homo sapiens	106-118
31257059-9	2019	Taken together, quercetin hampered OSCC tumorigenesis by regulating miR-22/WNT1/beta-catenin pathway in OSCC, providing a deep insight into the molecular targets of quercetin in the treatment of OSCC.	Quercetin	16-25	microRNA 22	Homo sapiens	68-74
31257059-9	2019	Taken together, quercetin hampered OSCC tumorigenesis by regulating miR-22/WNT1/beta-catenin pathway in OSCC, providing a deep insight into the molecular targets of quercetin in the treatment of OSCC.	Quercetin	16-25	Wnt family member 1	Homo sapiens	75-79
31257059-9	2019	Taken together, quercetin hampered OSCC tumorigenesis by regulating miR-22/WNT1/beta-catenin pathway in OSCC, providing a deep insight into the molecular targets of quercetin in the treatment of OSCC.	Quercetin	16-25	catenin beta 1	Homo sapiens	80-92
31257059-9	2019	Taken together, quercetin hampered OSCC tumorigenesis by regulating miR-22/WNT1/beta-catenin pathway in OSCC, providing a deep insight into the molecular targets of quercetin in the treatment of OSCC.	Quercetin	165-174	microRNA 22	Homo sapiens	68-74
31257059-9	2019	Taken together, quercetin hampered OSCC tumorigenesis by regulating miR-22/WNT1/beta-catenin pathway in OSCC, providing a deep insight into the molecular targets of quercetin in the treatment of OSCC.	Quercetin	165-174	Wnt family member 1	Homo sapiens	75-79
31257059-9	2019	Taken together, quercetin hampered OSCC tumorigenesis by regulating miR-22/WNT1/beta-catenin pathway in OSCC, providing a deep insight into the molecular targets of quercetin in the treatment of OSCC.	Quercetin	165-174	catenin beta 1	Homo sapiens	80-92
30942399-0	2019	Quercetin suppresses glomerulosclerosis and TGF-beta signaling in a rat model.	Quercetin	0-9	transforming growth factor, beta 1	Rattus norvegicus	44-52
30942399-2	2019	Quercetin is a common Chinese herbal medicine and has been reported to inhibit TGF-beta signaling pathway activation.	Quercetin	0-9	transforming growth factor, beta 1	Rattus norvegicus	79-87
30942399-5	2019	It was demonstrated that quercetin significantly improved physiological indices and altered the expression levels of TGF-beta signaling pathway-associated proteins in rats with glomerulosclerosis.	Quercetin	25-34	transforming growth factor, beta 1	Rattus norvegicus	117-125
30942399-6	2019	In conclusion, quercetin can regulate the TGF-beta signaling pathway and reduce the progression of glomerulosclerosis.	Quercetin	15-24	transforming growth factor, beta 1	Rattus norvegicus	42-50
30878575-5	2019	Hesperidin and quercetin treatment resulted in decreased levels of TNF-alpha and increased levels of IL-10.	Quercetin	15-24	interleukin 10	Rattus norvegicus	101-106
30878575-6	2019	Quercetin significantly decreased caspase 3/8/9 levels.	Quercetin	0-9	caspase 3	Rattus norvegicus	34-47
31140426-0	2019	[Quercetin alleviates lipopolysaccharide-induced acute kidney injury in mice by suppressing TLR4/NF-kappaB pathway].	Quercetin	1-10	toll-like receptor 4	Mus musculus	92-96
30849473-7	2019	The negative modulation of GSTA1 was efficiently reversed in the presence of quercetin, which significantly increased GSH levels as well.	Quercetin	77-86	glutathione S-transferase A1	Bos taurus	27-32
31239739-0	2019	Quercetin improves lipid metabolism via SCAP-SREBP2-LDLr signaling pathway in early stage diabetic nephropathy.	Quercetin	0-9	SREBF chaperone	Mus musculus	40-44
31239739-0	2019	Quercetin improves lipid metabolism via SCAP-SREBP2-LDLr signaling pathway in early stage diabetic nephropathy.	Quercetin	0-9	sterol regulatory element binding factor 2	Mus musculus	45-51
31239739-0	2019	Quercetin improves lipid metabolism via SCAP-SREBP2-LDLr signaling pathway in early stage diabetic nephropathy.	Quercetin	0-9	low density lipoprotein receptor	Mus musculus	52-56
31239739-11	2019	Conclusion: Quercetin safely and efficiently alleviates early diabetic renal injuries, possibly through improving the lipid metabolism via SCAP-SREBP2-LDLr signaling pathway.	Quercetin	12-21	SREBF chaperone	Mus musculus	139-143
31239739-11	2019	Conclusion: Quercetin safely and efficiently alleviates early diabetic renal injuries, possibly through improving the lipid metabolism via SCAP-SREBP2-LDLr signaling pathway.	Quercetin	12-21	sterol regulatory element binding factor 2	Mus musculus	144-150
31239739-11	2019	Conclusion: Quercetin safely and efficiently alleviates early diabetic renal injuries, possibly through improving the lipid metabolism via SCAP-SREBP2-LDLr signaling pathway.	Quercetin	12-21	low density lipoprotein receptor	Mus musculus	151-155
31140426-6	2019	Pretreatment with quercetin also significantly inhibited TLR4, MyD88, and TRAF-6 expressions and NF-kappaBp65 activation in the kidneys of the rats with LPS challenge (P &amp;lt; 0.05).	Quercetin	18-27	toll-like receptor 4	Rattus norvegicus	57-61
31140426-6	2019	Pretreatment with quercetin also significantly inhibited TLR4, MyD88, and TRAF-6 expressions and NF-kappaBp65 activation in the kidneys of the rats with LPS challenge (P &amp;lt; 0.05).	Quercetin	18-27	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	63-68
31140426-6	2019	Pretreatment with quercetin also significantly inhibited TLR4, MyD88, and TRAF-6 expressions and NF-kappaBp65 activation in the kidneys of the rats with LPS challenge (P &amp;lt; 0.05).	Quercetin	18-27	TNF receptor associated factor 6	Rattus norvegicus	74-80
31140426-7	2019	CONCLUSIONS: Quercetin pretreatment can protect mice against LPSinduced AKI by inhibiting TLR4/NF-kappaB signaling pathway.	Quercetin	13-22	toll-like receptor 4	Mus musculus	90-94
31140426-7	2019	CONCLUSIONS: Quercetin pretreatment can protect mice against LPSinduced AKI by inhibiting TLR4/NF-kappaB signaling pathway.	Quercetin	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-104
31140426-0	2019	[Quercetin alleviates lipopolysaccharide-induced acute kidney injury in mice by suppressing TLR4/NF-kappaB pathway].	Quercetin	1-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
31140426-5	2019	RESULTS: Quercetin significantly lessened renal pathologies, lowered BUN and creatinine levels (P &amp;lt; 0.05) and inhibited TNF-alpha, IL-1beta, and IL-6 production in mice with LPS-induced AKI (P &amp;lt; 0.05).	Quercetin	9-18	tumor necrosis factor	Mus musculus	127-136
31140426-5	2019	RESULTS: Quercetin significantly lessened renal pathologies, lowered BUN and creatinine levels (P &amp;lt; 0.05) and inhibited TNF-alpha, IL-1beta, and IL-6 production in mice with LPS-induced AKI (P &amp;lt; 0.05).	Quercetin	9-18	interleukin 1 beta	Mus musculus	138-146
31140426-5	2019	RESULTS: Quercetin significantly lessened renal pathologies, lowered BUN and creatinine levels (P &amp;lt; 0.05) and inhibited TNF-alpha, IL-1beta, and IL-6 production in mice with LPS-induced AKI (P &amp;lt; 0.05).	Quercetin	9-18	interleukin 6	Mus musculus	152-156
31137633-0	2019	Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway.	Quercetin	0-9	hexokinase 2	Homo sapiens	82-94
30636491-0	2019	Quercetin protects cardiomyocytes against doxorubicin-induced toxicity by suppressing oxidative stress and improving mitochondrial function via 14-3-3gamma.	Quercetin	0-9	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	144-155
31137633-0	2019	Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	99-102
31137633-0	2019	Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	103-107
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Quercetin	83-92	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	171-177
31092862-4	2019	During the molecular modelling studies of some naturally occurring flavonoids such as quercetin, luteolin, myricetin, kaempferol, naringin, hesperidin, galangin, baicalein and epicatechin with human ERalpha (3ERT and 1GWR), we observed that most of the ligands bound to the active site pocket of both 3ERT and 1GWR.	Quercetin	86-95	estrogen receptor 1	Homo sapiens	199-206
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Quercetin	83-92	sterol regulatory element binding transcription factor 2	Homo sapiens	178-184
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Quercetin	83-92	low density lipoprotein receptor	Homo sapiens	185-189
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Quercetin	83-92	hepatocyte nuclear factor 4 alpha	Homo sapiens	199-208
31098406-5	2019	The catechin EGCG ((-)-epigallocatechin gallate) and the flavonoids kaempferol and quercetin are identified as the bioactive components responsible for the effects on the NPC1L1-SREBP2-LDLR axis and HNF4alpha-MTP/APOB axis, respectively.	Quercetin	83-92	apolipoprotein B	Homo sapiens	213-217
31053743-7	2019	Comparative molecular docking studies show the better binding affinity of quercetin to RSK2, MSK1, CytC, Cdc42, Apaf1, FADD, CRK proteins.	Quercetin	74-83	ribosomal protein S6 kinase A5	Rattus norvegicus	93-97
31053743-7	2019	Comparative molecular docking studies show the better binding affinity of quercetin to RSK2, MSK1, CytC, Cdc42, Apaf1, FADD, CRK proteins.	Quercetin	74-83	cell division cycle 42	Rattus norvegicus	105-110
31053743-7	2019	Comparative molecular docking studies show the better binding affinity of quercetin to RSK2, MSK1, CytC, Cdc42, Apaf1, FADD, CRK proteins.	Quercetin	74-83	apoptotic peptidase activating factor 1	Rattus norvegicus	112-117
31053743-7	2019	Comparative molecular docking studies show the better binding affinity of quercetin to RSK2, MSK1, CytC, Cdc42, Apaf1, FADD, CRK proteins.	Quercetin	74-83	Fas associated via death domain	Rattus norvegicus	119-123
31053743-7	2019	Comparative molecular docking studies show the better binding affinity of quercetin to RSK2, MSK1, CytC, Cdc42, Apaf1, FADD, CRK proteins.	Quercetin	74-83	CRK proto-oncogene, adaptor protein	Rattus norvegicus	125-128
31217929-5	2019	While the levels of mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and malondialdehyde (MDA) decreased by the quercetin treatment in the liver mitochondria (P&lt;0.001), catalase (CAT) and glutathione (GSH) increased (P&lt;0.001).	Quercetin	134-143	catalase	Rattus norvegicus	194-202
30785766-10	2019	Coadministration of quercetin (1 or 20 mg/kg body weight) in an HF diet prevented TRPC-6 from declining and attenuated phosphorylated (p)-PKB and PI3k, as well as the proliferation of visceral fat cells.	Quercetin	20-29	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	82-88
30785766-12	2019	The food flavonoid quercetin was a TRPC-6 inducer and activator and it could prevent adipogenesis in mice.-Tan, Y. Q., Kwan, H. Y., Yao, X., Leung, L. K. The activity of transient receptor potential channel C-6 modulates the differentiation of fat cells.	Quercetin	19-28	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	35-41
30896828-9	2019	Luteolin (Lu) and quercetin (Qu) increased the expression of catalase and reduced H2O2 levels, but without an observed change in the protein levels of MnSOD.	Quercetin	18-27	catalase	Homo sapiens	61-69
30816608-6	2019	Also, co-administration of quercetin (especially at 40 and 80 muM) with hydrogen peroxide restored the toxic effects of hydrogen peroxide on rooster semen parameters such as primary and secondary lipid peroxidative indicators and other evaluated variables.	Quercetin	27-36	latexin	Homo sapiens	62-65
31065489-4	2019	Quercetin significantly reduced total leukocytes, eosinophils, tumor necrosis factor-alpha (TNF-alpha), interleukin (IL-6), nitric oxide (NO), and apoptosis.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	63-90
31065489-4	2019	Quercetin significantly reduced total leukocytes, eosinophils, tumor necrosis factor-alpha (TNF-alpha), interleukin (IL-6), nitric oxide (NO), and apoptosis.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	92-101
31065489-4	2019	Quercetin significantly reduced total leukocytes, eosinophils, tumor necrosis factor-alpha (TNF-alpha), interleukin (IL-6), nitric oxide (NO), and apoptosis.	Quercetin	0-9	interleukin 6	Rattus norvegicus	117-121
31065489-8	2019	Quercetin considerably reduced the protein expression of iNOS.	Quercetin	0-9	nitric oxide synthase 2	Rattus norvegicus	57-61
30609097-7	2019	The quercetin treated group showed higher SOD and TIMP-1 expressions but lower MMP-13 expression than untreated OA group in the serum, synovial fluid and synovial tissues (p < .05).	Quercetin	4-13	metalloproteinase inhibitor 1	Oryctolagus cuniculus	50-56
30609097-7	2019	The quercetin treated group showed higher SOD and TIMP-1 expressions but lower MMP-13 expression than untreated OA group in the serum, synovial fluid and synovial tissues (p < .05).	Quercetin	4-13	collagenase 3	Oryctolagus cuniculus	79-85
30609097-9	2019	The MMP-13/TIMP-1 ratio of the quercetin treated group was significantly lower than that of the untreated OA group (p < .05).	Quercetin	31-40	collagenase 3	Oryctolagus cuniculus	4-10
30609097-9	2019	The MMP-13/TIMP-1 ratio of the quercetin treated group was significantly lower than that of the untreated OA group (p < .05).	Quercetin	31-40	metalloproteinase inhibitor 1	Oryctolagus cuniculus	11-17
30609097-10	2019	Quercetin can up-regulate SOD and TIMP-1, down-regulate MMP-13, and improve the degeneration of OA through weakening the oxidative stress responses and inhibiting the degradation of cartilage extracellular matrix.	Quercetin	0-9	metalloproteinase inhibitor 1	Oryctolagus cuniculus	34-40
30609097-10	2019	Quercetin can up-regulate SOD and TIMP-1, down-regulate MMP-13, and improve the degeneration of OA through weakening the oxidative stress responses and inhibiting the degradation of cartilage extracellular matrix.	Quercetin	0-9	collagenase 3	Oryctolagus cuniculus	56-62
30822517-9	2019	Notably, quercetin increased the number of DCX-expressing cells, indicating the active dynamic growth of neural progenitor cells in the dentate gyrus of the hippocampus.	Quercetin	9-18	doublecortin	Rattus norvegicus	43-46
30822517-10	2019	We further observed that the quercetin improved the number of BrdU/NeuN positive cells contributed to enhanced adult neurogenesis.	Quercetin	29-38	RNA binding fox-1 homolog 3	Rattus norvegicus	67-71
30822517-11	2019	Based on our results, quercetin had the potential to promote the expression of BDNF, NGF, CREB, and EGR-1 genes involved in regulating neurogenesis.	Quercetin	22-31	brain-derived neurotrophic factor	Rattus norvegicus	79-83
30822517-11	2019	Based on our results, quercetin had the potential to promote the expression of BDNF, NGF, CREB, and EGR-1 genes involved in regulating neurogenesis.	Quercetin	22-31	nerve growth factor	Rattus norvegicus	85-88
30822517-11	2019	Based on our results, quercetin had the potential to promote the expression of BDNF, NGF, CREB, and EGR-1 genes involved in regulating neurogenesis.	Quercetin	22-31	cAMP responsive element binding protein 1	Rattus norvegicus	90-94
30822517-11	2019	Based on our results, quercetin had the potential to promote the expression of BDNF, NGF, CREB, and EGR-1 genes involved in regulating neurogenesis.	Quercetin	22-31	early growth response 1	Rattus norvegicus	100-105
31217929-5	2019	While the levels of mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and malondialdehyde (MDA) decreased by the quercetin treatment in the liver mitochondria (P&lt;0.001), catalase (CAT) and glutathione (GSH) increased (P&lt;0.001).	Quercetin	134-143	catalase	Rattus norvegicus	204-207
30914316-9	2019	The neuroprotective effects of quercetin are mainly due to potential up- and/or down-regulation of cytokines via nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Paraoxonase-2, c-Jun N-terminal kinase (JNK), Protein kinase C, Mitogen-activated protein kinase (MAPK) signalling cascades, and PI3K/Akt pathways.	Quercetin	31-40	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
30914316-9	2019	The neuroprotective effects of quercetin are mainly due to potential up- and/or down-regulation of cytokines via nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Paraoxonase-2, c-Jun N-terminal kinase (JNK), Protein kinase C, Mitogen-activated protein kinase (MAPK) signalling cascades, and PI3K/Akt pathways.	Quercetin	31-40	paraoxonase 2	Homo sapiens	165-178
30914316-9	2019	The neuroprotective effects of quercetin are mainly due to potential up- and/or down-regulation of cytokines via nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Paraoxonase-2, c-Jun N-terminal kinase (JNK), Protein kinase C, Mitogen-activated protein kinase (MAPK) signalling cascades, and PI3K/Akt pathways.	Quercetin	31-40	mitogen-activated protein kinase 8	Homo sapiens	180-203
30914316-9	2019	The neuroprotective effects of quercetin are mainly due to potential up- and/or down-regulation of cytokines via nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Paraoxonase-2, c-Jun N-terminal kinase (JNK), Protein kinase C, Mitogen-activated protein kinase (MAPK) signalling cascades, and PI3K/Akt pathways.	Quercetin	31-40	mitogen-activated protein kinase 8	Homo sapiens	205-208
30914316-9	2019	The neuroprotective effects of quercetin are mainly due to potential up- and/or down-regulation of cytokines via nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Paraoxonase-2, c-Jun N-terminal kinase (JNK), Protein kinase C, Mitogen-activated protein kinase (MAPK) signalling cascades, and PI3K/Akt pathways.	Quercetin	31-40	AKT serine/threonine kinase 1	Homo sapiens	299-302
30848564-6	2019	In addition, subgroup analysis revealed a significant reduction in insulin concentrations following supplementation with quercetin in studies that enrolled individuals aged &lt;45 years (WMD: -1.36; 95% CI [-1.76, -0.97]) and that used quercetin in dosages of &gt;=500 mg/day (WMD: -1.57; 95% CI [-1.98, -1.16]).	Quercetin	121-130	insulin	Homo sapiens	67-74
30848564-6	2019	In addition, subgroup analysis revealed a significant reduction in insulin concentrations following supplementation with quercetin in studies that enrolled individuals aged &lt;45 years (WMD: -1.36; 95% CI [-1.76, -0.97]) and that used quercetin in dosages of &gt;=500 mg/day (WMD: -1.57; 95% CI [-1.98, -1.16]).	Quercetin	236-245	insulin	Homo sapiens	67-74
29768080-9	2019	The results also indicated that quercetin could increase losartan absorption rate by inhibiting the activity of P-gp and decrease its metabolic stability by inhibiting the activity of CYP450 enzyme.	Quercetin	32-41	phosphoglycolate phosphatase	Rattus norvegicus	112-116
29768080-11	2019	These results indicated that the herb-drug interaction between quercetin and losartan might occur when they are co-administered in rats, quercetin could increase the systemic exposure of losartan and decrease the plasma concentration of EXP3174, possibly by inhibiting the activity of P-gp or CYP450 enzyme.	Quercetin	63-72	phosphoglycolate phosphatase	Rattus norvegicus	285-289
29768080-11	2019	These results indicated that the herb-drug interaction between quercetin and losartan might occur when they are co-administered in rats, quercetin could increase the systemic exposure of losartan and decrease the plasma concentration of EXP3174, possibly by inhibiting the activity of P-gp or CYP450 enzyme.	Quercetin	137-146	phosphoglycolate phosphatase	Rattus norvegicus	285-289
31114202-0	2019	Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kappaB signaling and Nrf2 pathway in high fat diet fed mice [Retraction].	Quercetin	5-14	toll-like receptor 4	Mus musculus	95-99
31035637-0	2019	The Flavonoid Quercetin Induces AP-1 Activation in FRTL-5 Thyroid Cells.	Quercetin	14-23	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-36
31035637-6	2019	Electromobility shift assay experiments showed that the treatment with quercetin induced the binding of a protein complex to an oligonucleotide containing the AP-1 consensus binding site.	Quercetin	71-80	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	159-163
31035637-7	2019	This is the first study showing an effect of quercetin on AP-1 activity in thyroid cells.	Quercetin	45-54	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-62
31035637-8	2019	Further studies are in progress to understand the role of AP-1 activation in the effects of quercetin on thyroid function.	Quercetin	92-101	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-62
31114202-0	2019	Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kappaB signaling and Nrf2 pathway in high fat diet fed mice [Retraction].	Quercetin	5-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	100-109
31114202-0	2019	Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kappaB signaling and Nrf2 pathway in high fat diet fed mice [Retraction].	Quercetin	5-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
30865735-4	2019	In vitro alpha-glucosidase inhibitory assay verified that quercetin-3-O-glucuronide, kaempferol-3-O-rhamnoside, quercetin, kaempferol, asiatic acid and genistein were primarily responsible for the alpha-glucosidase inhibitory activity of the CP extract.	Quercetin	58-67	sucrase isomaltase (alpha-glucosidase)	Mus musculus	9-26
30933559-0	2019	Quercetin-Modified Metal-Organic Frameworks for Dual Sensitization of Radiotherapy in Tumor Tissues by Inhibiting the Carbonic Anhydrase IX.	Quercetin	0-9	carbonic anhydrase 9	Homo sapiens	118-139
30933559-3	2019	In this paper, a stable nanocomposite was engineered to overcome the hypoxia properties by using 1,4-benzenedicarboxylic acid produced from a Zr-MOF as a carbonic anhydrase IX (CA IX) inhibitor and quercetin (QU) as a radiosensitizer.	Quercetin	198-207	carbonic anhydrase 9	Homo sapiens	177-182
31061913-6	2019	Whereas, 50 mg/kg quercetin, and 50 mg/kg Naringenin decreased the oxidative stress (increased SOD, CAT, GSH, and reduced MDA) induced by cART (reduced SOD, CAT, GSH, and increased MDA).	Quercetin	18-27	catalase	Rattus norvegicus	100-103
31061913-6	2019	Whereas, 50 mg/kg quercetin, and 50 mg/kg Naringenin decreased the oxidative stress (increased SOD, CAT, GSH, and reduced MDA) induced by cART (reduced SOD, CAT, GSH, and increased MDA).	Quercetin	18-27	catalase	Rattus norvegicus	157-160
31061913-8	2019	Furthermore, immunohistochemical studies revealed that quercetin and naringenin attenuates cART-induced upregulation of monoamine oxidase-B (MAO-B) expression.	Quercetin	55-64	monoamine oxidase B	Rattus norvegicus	120-139
31061913-8	2019	Furthermore, immunohistochemical studies revealed that quercetin and naringenin attenuates cART-induced upregulation of monoamine oxidase-B (MAO-B) expression.	Quercetin	55-64	monoamine oxidase B	Rattus norvegicus	141-146
30833078-6	2019	And quercetin and ascorbic acid suppressed translocation of TXNIP.	Quercetin	4-13	thioredoxin interacting protein	Homo sapiens	60-65
30833078-7	2019	Binding between TXNIP and NLRP3 under oxidative stress caused by MSU crystals was observed and was blocked by quercetin or ascorbic acid.	Quercetin	110-119	thioredoxin interacting protein	Homo sapiens	16-21
30833078-7	2019	Binding between TXNIP and NLRP3 under oxidative stress caused by MSU crystals was observed and was blocked by quercetin or ascorbic acid.	Quercetin	110-119	NLR family pyrin domain containing 3	Homo sapiens	26-31
30970656-0	2019	Fluorescence Spectroscopic Investigation of Competitive Interactions between Quercetin and Aflatoxin B1 for Binding to Human Serum Albumin.	Quercetin	77-86	albumin	Homo sapiens	125-138
30958872-5	2019	Further, quercetin co-treatment ameliorated DCM-mediated decrease in the hepatic and renal activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase as well as glutathione level in the treated rats.	Quercetin	9-18	catalase	Rattus norvegicus	127-135
30958872-5	2019	Further, quercetin co-treatment ameliorated DCM-mediated decrease in the hepatic and renal activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase as well as glutathione level in the treated rats.	Quercetin	9-18	hematopoietic prostaglandin D synthase	Rattus norvegicus	164-189
30986945-2	2019	The aim of this study is to investigate the potential role of noncoding miRNAs as endogenous and quercetin as exogenous regulators of Nrf2 pathway in bovine granulosa cells.	Quercetin	97-106	NFE2 like bZIP transcription factor 2	Bos taurus	134-138
30865451-0	2019	Oxidative Transformation of Leucocyanidin by Anthocyanidin Synthase from Vitis vinifera Leads Only to Quercetin.	Quercetin	102-111	leucoanthocyanidin dioxygenase	Vitis vinifera	45-67
30865451-1	2019	Anthocyanidin synthase from Vitis vinifera ( VvANS) catalyzes the in vitro transformation of the natural isomer of leucocyanidin, 2 R,3 S,4 S- cis-leucocyanidin, into 2 R,4 S-flavan-3,3,4-triol ([M + H]+, m/ z 323) and quercetin.	Quercetin	219-228	leucoanthocyanidin dioxygenase	Vitis vinifera	0-22
30987086-7	2019	In conclusion, the mixture of RSV + QRC has benefic effects on OS in fatty liver in the MS rats through the improvement of the antioxidant capacity and by the over-expression of the master factor Nrf2, which increases the antioxidant enzymes and GSH recycling.	Quercetin	36-39	NFE2 like bZIP transcription factor 2	Rattus norvegicus	196-200
30882424-9	2019	The dysregulation of the HPA axis in mTBI-induced mice treated with quercetin was also attenuated, with decreased levels of adrenocorticotropic hormone and corticosterone.	Quercetin	68-77	pro-opiomelanocortin-alpha	Mus musculus	124-151
30685603-8	2019	TNF-alpha significantly increased MMP-9 promoter activity and THP-1 cell adherence, and these effects were attenuated by pretreatment with quercetin, rottlerin, SP600125, U0126, tanshinone IIA or Bay 11-7082.	Quercetin	139-148	tumor necrosis factor	Homo sapiens	0-9
30685603-0	2019	Anti-inflammatory property of quercetin through downregulation of ICAM-1 and MMP-9 in TNF-alpha-activated retinal pigment epithelial cells.	Quercetin	30-39	intercellular adhesion molecule 1	Homo sapiens	66-72
30685603-8	2019	TNF-alpha significantly increased MMP-9 promoter activity and THP-1 cell adherence, and these effects were attenuated by pretreatment with quercetin, rottlerin, SP600125, U0126, tanshinone IIA or Bay 11-7082.	Quercetin	139-148	matrix metallopeptidase 9	Homo sapiens	34-39
30685603-0	2019	Anti-inflammatory property of quercetin through downregulation of ICAM-1 and MMP-9 in TNF-alpha-activated retinal pigment epithelial cells.	Quercetin	30-39	matrix metallopeptidase 9	Homo sapiens	77-82
30685603-0	2019	Anti-inflammatory property of quercetin through downregulation of ICAM-1 and MMP-9 in TNF-alpha-activated retinal pigment epithelial cells.	Quercetin	30-39	tumor necrosis factor	Homo sapiens	86-95
30685603-2	2019	The goal of the present investigation was to investigate the effects of quercetin on tumor necrosis factor-alpha (TNF-alpha)-induced inflammatory responses via the expression of ICAM-1 and MMP-9 in human retinal pigment epithelial cells (ARPE-19 cells).	Quercetin	72-81	tumor necrosis factor	Homo sapiens	85-112
30685603-2	2019	The goal of the present investigation was to investigate the effects of quercetin on tumor necrosis factor-alpha (TNF-alpha)-induced inflammatory responses via the expression of ICAM-1 and MMP-9 in human retinal pigment epithelial cells (ARPE-19 cells).	Quercetin	72-81	tumor necrosis factor	Homo sapiens	114-123
30685603-2	2019	The goal of the present investigation was to investigate the effects of quercetin on tumor necrosis factor-alpha (TNF-alpha)-induced inflammatory responses via the expression of ICAM-1 and MMP-9 in human retinal pigment epithelial cells (ARPE-19 cells).	Quercetin	72-81	intercellular adhesion molecule 1	Homo sapiens	178-184
30685603-2	2019	The goal of the present investigation was to investigate the effects of quercetin on tumor necrosis factor-alpha (TNF-alpha)-induced inflammatory responses via the expression of ICAM-1 and MMP-9 in human retinal pigment epithelial cells (ARPE-19 cells).	Quercetin	72-81	matrix metallopeptidase 9	Homo sapiens	189-194
30685603-5	2019	Quercetin inhibited the TNF-alpha-induced phosphorylation of PKCdelta, JNK1/2, ERK1/2.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	24-33
30685603-9	2019	These results suggest that quercetin attenuates TNF-alpha-induced ICAM-1 and MMP-9 expression in ARPE-19 cells via the MEK1/2-ERK1/2 and PKCdelta-JNK1/2-c-Jun or NF-kappaB pathways.	Quercetin	27-36	tumor necrosis factor	Homo sapiens	48-57
30685603-5	2019	Quercetin inhibited the TNF-alpha-induced phosphorylation of PKCdelta, JNK1/2, ERK1/2.	Quercetin	0-9	protein kinase C delta	Homo sapiens	61-69
30685603-9	2019	These results suggest that quercetin attenuates TNF-alpha-induced ICAM-1 and MMP-9 expression in ARPE-19 cells via the MEK1/2-ERK1/2 and PKCdelta-JNK1/2-c-Jun or NF-kappaB pathways.	Quercetin	27-36	intercellular adhesion molecule 1	Homo sapiens	66-72
30685603-5	2019	Quercetin inhibited the TNF-alpha-induced phosphorylation of PKCdelta, JNK1/2, ERK1/2.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	71-77
30685603-9	2019	These results suggest that quercetin attenuates TNF-alpha-induced ICAM-1 and MMP-9 expression in ARPE-19 cells via the MEK1/2-ERK1/2 and PKCdelta-JNK1/2-c-Jun or NF-kappaB pathways.	Quercetin	27-36	matrix metallopeptidase 9	Homo sapiens	77-82
30685603-5	2019	Quercetin inhibited the TNF-alpha-induced phosphorylation of PKCdelta, JNK1/2, ERK1/2.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	79-85
30685603-9	2019	These results suggest that quercetin attenuates TNF-alpha-induced ICAM-1 and MMP-9 expression in ARPE-19 cells via the MEK1/2-ERK1/2 and PKCdelta-JNK1/2-c-Jun or NF-kappaB pathways.	Quercetin	27-36	mitogen-activated protein kinase kinase 1	Homo sapiens	119-125
30685603-6	2019	Quercetin, rottlerin, SP600125 and U0126 attenuated TNF-alpha-stimulated c-Jun phosphorylation and AP-1-Luc activity.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	52-61
30685603-6	2019	Quercetin, rottlerin, SP600125 and U0126 attenuated TNF-alpha-stimulated c-Jun phosphorylation and AP-1-Luc activity.	Quercetin	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
30685603-7	2019	Pretreatment with quercetin, rottlerin, SP600125, or Bay 11-7082 attenuated TNF-alpha-induced NF-kappaB (p65) phosphorylation, translocation and RelA/p65-Luc activity.	Quercetin	18-27	tumor necrosis factor	Homo sapiens	76-85
30685603-9	2019	These results suggest that quercetin attenuates TNF-alpha-induced ICAM-1 and MMP-9 expression in ARPE-19 cells via the MEK1/2-ERK1/2 and PKCdelta-JNK1/2-c-Jun or NF-kappaB pathways.	Quercetin	27-36	mitogen-activated protein kinase 3	Homo sapiens	126-132
30685603-7	2019	Pretreatment with quercetin, rottlerin, SP600125, or Bay 11-7082 attenuated TNF-alpha-induced NF-kappaB (p65) phosphorylation, translocation and RelA/p65-Luc activity.	Quercetin	18-27	RELA proto-oncogene, NF-kB subunit	Homo sapiens	105-108
30685603-9	2019	These results suggest that quercetin attenuates TNF-alpha-induced ICAM-1 and MMP-9 expression in ARPE-19 cells via the MEK1/2-ERK1/2 and PKCdelta-JNK1/2-c-Jun or NF-kappaB pathways.	Quercetin	27-36	protein kinase C delta	Homo sapiens	137-145
30685603-7	2019	Pretreatment with quercetin, rottlerin, SP600125, or Bay 11-7082 attenuated TNF-alpha-induced NF-kappaB (p65) phosphorylation, translocation and RelA/p65-Luc activity.	Quercetin	18-27	RELA proto-oncogene, NF-kB subunit	Homo sapiens	145-149
30685603-7	2019	Pretreatment with quercetin, rottlerin, SP600125, or Bay 11-7082 attenuated TNF-alpha-induced NF-kappaB (p65) phosphorylation, translocation and RelA/p65-Luc activity.	Quercetin	18-27	RELA proto-oncogene, NF-kB subunit	Homo sapiens	150-153
30685603-9	2019	These results suggest that quercetin attenuates TNF-alpha-induced ICAM-1 and MMP-9 expression in ARPE-19 cells via the MEK1/2-ERK1/2 and PKCdelta-JNK1/2-c-Jun or NF-kappaB pathways.	Quercetin	27-36	mitogen-activated protein kinase 8	Homo sapiens	146-152
30685603-9	2019	These results suggest that quercetin attenuates TNF-alpha-induced ICAM-1 and MMP-9 expression in ARPE-19 cells via the MEK1/2-ERK1/2 and PKCdelta-JNK1/2-c-Jun or NF-kappaB pathways.	Quercetin	27-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	153-158
30630075-8	2019	Consistent with these observations, exogenous application of the flavonol quercetin restored the root meristem size of myb12 ga1-3 to that of ga1-3.	Quercetin	74-83	Terpenoid cyclases/Protein prenyltransferases superfamily protein	Arabidopsis thaliana	125-130
30810849-10	2019	Quercetin was used as positive control, and strong binding energy of -7.54 kcal/mol with EGFR is in accordance with experimental evidence.	Quercetin	0-9	epidermal growth factor receptor	Homo sapiens	89-93
31168343-0	2019	Quercetin protects PC-12 cells against hypoxia injury by down-regulation of miR-122.	Quercetin	0-9	microRNA 122	Rattus norvegicus	76-83
30934771-5	2019	8-OHdG and Hsp70 protein expressions were up-regulated markedly by light exposure and suppressed by quercetin pretreatment.	Quercetin	100-109	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	11-16
30680920-5	2019	Based on the evaluation of hallmark characteristics of NAFLD, it is found that gut microbiota transplantation from the HFD-non-responder donor and the HFD-fed donor with the highest response to quercetin results in a protective phenotype against HFD-induced NAFLD, in a mechanism that involves gut-liver axis alteration blockage in these receivers.	Quercetin	194-203	TSC complex subunit 2	Mus musculus	55-60
30680920-5	2019	Based on the evaluation of hallmark characteristics of NAFLD, it is found that gut microbiota transplantation from the HFD-non-responder donor and the HFD-fed donor with the highest response to quercetin results in a protective phenotype against HFD-induced NAFLD, in a mechanism that involves gut-liver axis alteration blockage in these receivers.	Quercetin	194-203	TSC complex subunit 2	Mus musculus	258-263
30976294-10	2019	Four compounds including chlorogenic acid, quercetin-3-O-glucuronide, isoquercetin, and quercetin were identified as alpha-glucosidase inhibitors.	Quercetin	43-52	sucrase-isomaltase	Homo sapiens	117-134
30992663-8	2019	Conclusion: Different photographic analyses indicated that iron oxide nanoparticles function as an important factor in order to improve the efficiency of NGF through improving cell viability, cell attachment, and neurite outgrowth in the shelter of quercetin as an accelerator of these phenomena.	Quercetin	249-258	nerve growth factor	Rattus norvegicus	154-157
31090331-4	2019	Through the study of network pharmacology,12 components of aspirin and Trichosanthis Fructus,including hydroxygenkwanin,quercetin and adenosine,were found to show the anti-platelet aggregation and anti-thrombosis mechanisms through9 common protein targets,such as SRC,RAC1,MAPK14,MAPK1,AKT1,and 14 common signaling pathways,such as VEGF signaling pathway.	Quercetin	120-129	Rac family small GTPase 1	Rattus norvegicus	268-272
31090331-4	2019	Through the study of network pharmacology,12 components of aspirin and Trichosanthis Fructus,including hydroxygenkwanin,quercetin and adenosine,were found to show the anti-platelet aggregation and anti-thrombosis mechanisms through9 common protein targets,such as SRC,RAC1,MAPK14,MAPK1,AKT1,and 14 common signaling pathways,such as VEGF signaling pathway.	Quercetin	120-129	mitogen activated protein kinase 14	Rattus norvegicus	273-279
31090331-4	2019	Through the study of network pharmacology,12 components of aspirin and Trichosanthis Fructus,including hydroxygenkwanin,quercetin and adenosine,were found to show the anti-platelet aggregation and anti-thrombosis mechanisms through9 common protein targets,such as SRC,RAC1,MAPK14,MAPK1,AKT1,and 14 common signaling pathways,such as VEGF signaling pathway.	Quercetin	120-129	mitogen activated protein kinase 1	Rattus norvegicus	273-278
31090331-4	2019	Through the study of network pharmacology,12 components of aspirin and Trichosanthis Fructus,including hydroxygenkwanin,quercetin and adenosine,were found to show the anti-platelet aggregation and anti-thrombosis mechanisms through9 common protein targets,such as SRC,RAC1,MAPK14,MAPK1,AKT1,and 14 common signaling pathways,such as VEGF signaling pathway.	Quercetin	120-129	AKT serine/threonine kinase 1	Rattus norvegicus	286-290
31090331-4	2019	Through the study of network pharmacology,12 components of aspirin and Trichosanthis Fructus,including hydroxygenkwanin,quercetin and adenosine,were found to show the anti-platelet aggregation and anti-thrombosis mechanisms through9 common protein targets,such as SRC,RAC1,MAPK14,MAPK1,AKT1,and 14 common signaling pathways,such as VEGF signaling pathway.	Quercetin	120-129	vascular endothelial growth factor A	Rattus norvegicus	332-336
30934771-0	2019	Suppression of Light-Induced Retinal Degeneration by Quercetin via the AP-1 Pathway in Rats.	Quercetin	53-62	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-75
30934771-1	2019	We examined the cytoprotective effect of quercetin via activator protein (AP-1) and the heat shock protein 70 (Hsp70) pathway against light-induced retinal degeneration in rats.	Quercetin	41-50	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-78
30934771-2	2019	Quercetin was administered intraperitoneally to Sprague-Dawley rats for seven days before light exposure to intense white fluorescent light (3000 lux) for 24 h. Light-induced retinal damage was determined by the number of rows of photoreceptor cell nuclei, the microstructures of the rod outer segments and retinal pigment epithelium, and terminal deoxynucleotidyl transferase (TdT)-mediated 2"-Deoxyuridine-5"-triphosphate (dUTP) nick end labeling.	Quercetin	0-9	DNA nucleotidylexotransferase	Rattus norvegicus	339-376
30934771-2	2019	Quercetin was administered intraperitoneally to Sprague-Dawley rats for seven days before light exposure to intense white fluorescent light (3000 lux) for 24 h. Light-induced retinal damage was determined by the number of rows of photoreceptor cell nuclei, the microstructures of the rod outer segments and retinal pigment epithelium, and terminal deoxynucleotidyl transferase (TdT)-mediated 2"-Deoxyuridine-5"-triphosphate (dUTP) nick end labeling.	Quercetin	0-9	DNA nucleotidylexotransferase	Rattus norvegicus	378-381
30934771-8	2019	Suppression of the heterodimeric combination of c-Jun and c-Fos proteins at the AP-1 binding site is highly involved in quercetin-mediated cytoprotection.	Quercetin	120-129	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-63
30934771-8	2019	Suppression of the heterodimeric combination of c-Jun and c-Fos proteins at the AP-1 binding site is highly involved in quercetin-mediated cytoprotection.	Quercetin	120-129	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	80-84
30609277-5	2019	Quercetin acts as a GLP-1R PAM and DPP-4 inhibitor, and therefore, might be considered as a pioneering agent with a dual mechanism of action, in terms of GLP-1R positive allosteric modulation and DPP-4 inhibition for potentiating GLP-1 dependent effects.	Quercetin	0-9	dipeptidyl peptidase 4	Homo sapiens	35-40
30989139-0	2019	Development of a UHPLC-MS/MS Method for the Determination of Quercetin in Milk and its Application to a Pharmacokinetic Study.	Quercetin	61-70	Weaning weight-maternal milk	Bos taurus	74-78
30989139-2	2019	The aim of this study was to develop and validate a rapid and simple ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) method for the determination of quercetin in milk.	Quercetin	190-199	Weaning weight-maternal milk	Bos taurus	203-207
30989139-8	2019	Conclusion: The proposed method was successfully applied in evaluating the pharmacokinetics of quercetin in milk obtained from dairy cows with clinical mastitis after intramammary administration.	Quercetin	95-104	Weaning weight-maternal milk	Bos taurus	108-112
30639311-0	2019	Quercetin inhibits cell viability, migration and invasion by regulating miR-16/HOXA10 axis in oral cancer.	Quercetin	0-9	homeobox A10	Homo sapiens	79-85
30639311-7	2019	Results showed that quercetin suppressed cell viability, migration, invasion and abundances of metalloproteinase-9 (MMP-9) and MMP-2 in oral cancer cells.	Quercetin	20-29	matrix metallopeptidase 9	Homo sapiens	116-121
30639311-7	2019	Results showed that quercetin suppressed cell viability, migration, invasion and abundances of metalloproteinase-9 (MMP-9) and MMP-2 in oral cancer cells.	Quercetin	20-29	matrix metallopeptidase 2	Homo sapiens	127-132
30639311-12	2019	Collectively, quercetin inhibited cell viability, migration and invasion by regulating miR-16 and HOXA10 in oral cancer cells.	Quercetin	14-23	homeobox A10	Homo sapiens	98-104
30668339-13	2019	Based on data, autophagy was blocked at the late stage by high glucose concentration while quercetin enhanced autophagic response by reducing the P62 level coincided with the induction of Beclin-1 and LC3-II to LC3-I ratio (P &lt; 0.05).	Quercetin	91-100	nucleoporin 62	Homo sapiens	146-149
30668339-13	2019	Based on data, autophagy was blocked at the late stage by high glucose concentration while quercetin enhanced autophagic response by reducing the P62 level coincided with the induction of Beclin-1 and LC3-II to LC3-I ratio (P &lt; 0.05).	Quercetin	91-100	beclin 1	Homo sapiens	188-196
30668339-13	2019	Based on data, autophagy was blocked at the late stage by high glucose concentration while quercetin enhanced autophagic response by reducing the P62 level coincided with the induction of Beclin-1 and LC3-II to LC3-I ratio (P &lt; 0.05).	Quercetin	91-100	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	201-204
30668339-13	2019	Based on data, autophagy was blocked at the late stage by high glucose concentration while quercetin enhanced autophagic response by reducing the P62 level coincided with the induction of Beclin-1 and LC3-II to LC3-I ratio (P &lt; 0.05).	Quercetin	91-100	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	211-214
30609277-5	2019	Quercetin acts as a GLP-1R PAM and DPP-4 inhibitor, and therefore, might be considered as a pioneering agent with a dual mechanism of action, in terms of GLP-1R positive allosteric modulation and DPP-4 inhibition for potentiating GLP-1 dependent effects.	Quercetin	0-9	glucagon like peptide 1 receptor	Homo sapiens	20-26
30609277-5	2019	Quercetin acts as a GLP-1R PAM and DPP-4 inhibitor, and therefore, might be considered as a pioneering agent with a dual mechanism of action, in terms of GLP-1R positive allosteric modulation and DPP-4 inhibition for potentiating GLP-1 dependent effects.	Quercetin	0-9	dipeptidyl peptidase 4	Homo sapiens	196-201
30609277-5	2019	Quercetin acts as a GLP-1R PAM and DPP-4 inhibitor, and therefore, might be considered as a pioneering agent with a dual mechanism of action, in terms of GLP-1R positive allosteric modulation and DPP-4 inhibition for potentiating GLP-1 dependent effects.	Quercetin	0-9	glucagon like peptide 1 receptor	Homo sapiens	20-25
31089582-0	2019	Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation (J Obes Metab Syndr 2018;27:102-9).	Quercetin	0-9	uncoupling protein 1	Homo sapiens	22-42
30620686-10	2019	Moreover, IRE-1 activator, Quercetin, and adeno-associated virus serotype-9-delivered XBP-1s were able to relieve ER dysfunction in Pak2-CKO hearts.	Quercetin	27-36	p21 (RAC1) activated kinase 2	Mus musculus	132-136
30387535-6	2019	We show bioflavonoids genistein and quercetin most biochemically similar to etoposide have a strong association with MLL-AF9 bcr translocations, while kaempferol, fisetin, flavone, and myricetin have a weak but consistent association, and other compounds have a minimal association in both embryonic stem (ES) and hematopoietic stem cell (HSC) populations.	Quercetin	36-45	lysine methyltransferase 2A	Homo sapiens	117-120
30387535-6	2019	We show bioflavonoids genistein and quercetin most biochemically similar to etoposide have a strong association with MLL-AF9 bcr translocations, while kaempferol, fisetin, flavone, and myricetin have a weak but consistent association, and other compounds have a minimal association in both embryonic stem (ES) and hematopoietic stem cell (HSC) populations.	Quercetin	36-45	MLLT3 super elongation complex subunit	Homo sapiens	121-124
30145789-8	2019	Quercetin treatment also lowered the elevated coexpression of P2X4 and glial fibrillary acidic protein (a marker of SGCs) and decreased the upregulation of phosphorylated p38 mitogen-activated protein kinase (p38MAPK) in the DRG of diabetic rats.	Quercetin	0-9	glial fibrillary acidic protein	Rattus norvegicus	71-102
30145789-8	2019	Quercetin treatment also lowered the elevated coexpression of P2X4 and glial fibrillary acidic protein (a marker of SGCs) and decreased the upregulation of phosphorylated p38 mitogen-activated protein kinase (p38MAPK) in the DRG of diabetic rats.	Quercetin	0-9	mitogen activated protein kinase 14	Rattus norvegicus	171-207
30145789-8	2019	Quercetin treatment also lowered the elevated coexpression of P2X4 and glial fibrillary acidic protein (a marker of SGCs) and decreased the upregulation of phosphorylated p38 mitogen-activated protein kinase (p38MAPK) in the DRG of diabetic rats.	Quercetin	0-9	mitogen activated protein kinase 14	Rattus norvegicus	209-216
30145789-10	2019	Thus, our data demonstrate that quercetin may decrease the upregulation of the P2X4 receptor in DRG SGCs, and consequently inhibit P2X4 receptor-mediated p38MAPK activation to relieve the mechanical and thermal hyperalgesia in diabetic rats.	Quercetin	32-41	mitogen activated protein kinase 14	Rattus norvegicus	154-161
30779137-10	2019	Ten polyphenol compounds were identified in PF-A and PF-B, respectively, by HPLC-MS/MS, including quercetin, apigenin, myricetin, and so on.	Quercetin	98-107	keratin 75	Homo sapiens	53-57
30841446-5	2019	In this study, two quercetin derivatives, diquercetin and 2-chloro-1,4-naphtoquinone-quercetin, were identified as promising SIRT6 inhibitors with IC50 values of 130 muM and 55 muM, respectively.	Quercetin	19-28	sirtuin 6	Homo sapiens	125-130
30841446-5	2019	In this study, two quercetin derivatives, diquercetin and 2-chloro-1,4-naphtoquinone-quercetin, were identified as promising SIRT6 inhibitors with IC50 values of 130 muM and 55 muM, respectively.	Quercetin	19-28	latexin	Homo sapiens	166-169
30841446-5	2019	In this study, two quercetin derivatives, diquercetin and 2-chloro-1,4-naphtoquinone-quercetin, were identified as promising SIRT6 inhibitors with IC50 values of 130 muM and 55 muM, respectively.	Quercetin	19-28	latexin	Homo sapiens	177-180
30841446-9	2019	Overall, the results of in vitro studies and molecular modeling indicate that diquercetin competes with nicotinamide adenine dinucleotide (NAD+), whereas 2-chloro-1,4-naphthoquinone-quercetin competes with the acetylated substrate in the catalytic site of SIRT6.	Quercetin	80-89	sirtuin 6	Homo sapiens	256-261
30747009-9	2019	Further, chlorpyrifos exposure significantly elevated the levels of lipid peroxidation and protein carbonyl contents as well as the activities of catalase, superoxide dismutase, which were interestingly found to be decreased following co-treatment with quercetin.	Quercetin	253-262	catalase	Rattus norvegicus	146-154
29594477-5	2019	RESULTS: Both oral and intraperitoneal (IP) quercetin caused serum and tissue iron depletion by two means, first by increasing mucosal iron uptake and inhibiting iron efflux from duodenal mucosa, and second by decreasing levels of duodenal DMT1, Dcytb and FPN.	Quercetin	44-53	RoBo-1	Rattus norvegicus	240-244
29594477-5	2019	RESULTS: Both oral and intraperitoneal (IP) quercetin caused serum and tissue iron depletion by two means, first by increasing mucosal iron uptake and inhibiting iron efflux from duodenal mucosa, and second by decreasing levels of duodenal DMT1, Dcytb and FPN.	Quercetin	44-53	cytochrome b reductase 1	Rattus norvegicus	246-251
29594477-6	2019	Additionally, IP quercetin induced highly significant increased liver expression of hepcidin, a hormone known to inhibit intestinal iron uptake.	Quercetin	17-26	hepcidin antimicrobial peptide	Rattus norvegicus	84-92
30580029-6	2019	Furthermore, quercetin promoted lipophagy confirmed by the decreased perilipin 2 (PLIN2) level, activated AMPK activity and increased co-localization of liver LC3II and PLIN2 proteins.	Quercetin	13-22	predicted gene 12551	Mus musculus	69-80
30580029-6	2019	Furthermore, quercetin promoted lipophagy confirmed by the decreased perilipin 2 (PLIN2) level, activated AMPK activity and increased co-localization of liver LC3II and PLIN2 proteins.	Quercetin	13-22	predicted gene 12551	Mus musculus	82-87
30580029-6	2019	Furthermore, quercetin promoted lipophagy confirmed by the decreased perilipin 2 (PLIN2) level, activated AMPK activity and increased co-localization of liver LC3II and PLIN2 proteins.	Quercetin	13-22	predicted gene 12551	Mus musculus	169-174
31089583-0	2019	Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation (J Obes Metab Syndr 2018;27:102-9).	Quercetin	0-9	uncoupling protein 1	Homo sapiens	22-42
30637814-3	2019	Moreover, it exhibited significantly (p &lt; 0.05) stronger inhibitory effect on nuclear translocation of nuclear factor-kappaB (NF-kappaB) by suppressing the phosphorylation of NF-kappaB p65 and p50 submits and on the phosphorylation of ETS domain-containing protein and c-Jun N-terminal kinase than any of quercetin or catechin alone.	Quercetin	308-317	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	106-127
30664221-0	2019	Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression-independent manner in HPV-positive human cervical cancer-derived cells.	Quercetin	0-9	tumor protein p53	Homo sapiens	71-74
30664221-7	2019	In the present study, it was demonstrated that quercetin induced G2 phase cell cycle arrest and apoptosis in both HeLa and SiHa cells, accompanied by an increase of p53 and its nuclear signal.	Quercetin	47-56	tumor protein p53	Homo sapiens	165-168
30664221-8	2019	It was also observed that quercetin increased the level of the p21 transcript and the pro-apoptotic Bax protein, which are two p53-downstream effectors.	Quercetin	26-35	H3 histone pseudogene 16	Homo sapiens	63-66
30664221-8	2019	It was also observed that quercetin increased the level of the p21 transcript and the pro-apoptotic Bax protein, which are two p53-downstream effectors.	Quercetin	26-35	BCL2 associated X, apoptosis regulator	Homo sapiens	100-103
30664221-8	2019	It was also observed that quercetin increased the level of the p21 transcript and the pro-apoptotic Bax protein, which are two p53-downstream effectors.	Quercetin	26-35	tumor protein p53	Homo sapiens	127-130
30664221-9	2019	However, quercetin did not alter the expression of the HPV E6 protein in cervical cancer cells; therefore, the increase in p53 occurred in an E6 expression-independent manner.	Quercetin	9-18	tumor protein p53	Homo sapiens	123-126
30664221-10	2019	Furthermore, molecular docking demonstrated that quercetin binds stably in the central pocket of E6, the binding site of E6AP.	Quercetin	49-58	ubiquitin protein ligase E3A	Homo sapiens	121-125
30664221-11	2019	These data suggest that quercetin increases the nuclear localization of p53 by interrupting E6/E6AP complex formation in cervical cancer cells.	Quercetin	24-33	tumor protein p53	Homo sapiens	72-75
30664221-11	2019	These data suggest that quercetin increases the nuclear localization of p53 by interrupting E6/E6AP complex formation in cervical cancer cells.	Quercetin	24-33	ubiquitin protein ligase E3A	Homo sapiens	95-99
30637814-0	2019	Synergistic anti-inflammatory effects of quercetin and catechin via inhibiting activation of TLR4-MyD88-mediated NF-kappaB and MAPK signaling pathways.	Quercetin	41-50	toll-like receptor 4	Mus musculus	93-97
30637814-0	2019	Synergistic anti-inflammatory effects of quercetin and catechin via inhibiting activation of TLR4-MyD88-mediated NF-kappaB and MAPK signaling pathways.	Quercetin	41-50	myeloid differentiation primary response gene 88	Mus musculus	98-103
30637814-0	2019	Synergistic anti-inflammatory effects of quercetin and catechin via inhibiting activation of TLR4-MyD88-mediated NF-kappaB and MAPK signaling pathways.	Quercetin	41-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
30637814-2	2019	Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS-stimulated increase of some proinflammatory molecules, including nitric oxide, tumor necrosis factor alpha, interleukin-1beta, nitric oxide synthase, and cyclooxygenase-2.	Quercetin	46-55	tumor necrosis factor	Mus musculus	180-207
30637814-2	2019	Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS-stimulated increase of some proinflammatory molecules, including nitric oxide, tumor necrosis factor alpha, interleukin-1beta, nitric oxide synthase, and cyclooxygenase-2.	Quercetin	46-55	interleukin 1 beta	Mus musculus	209-226
30637814-2	2019	Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS-stimulated increase of some proinflammatory molecules, including nitric oxide, tumor necrosis factor alpha, interleukin-1beta, nitric oxide synthase, and cyclooxygenase-2.	Quercetin	46-55	prostaglandin-endoperoxide synthase 2	Mus musculus	255-271
30637814-3	2019	Moreover, it exhibited significantly (p &lt; 0.05) stronger inhibitory effect on nuclear translocation of nuclear factor-kappaB (NF-kappaB) by suppressing the phosphorylation of NF-kappaB p65 and p50 submits and on the phosphorylation of ETS domain-containing protein and c-Jun N-terminal kinase than any of quercetin or catechin alone.	Quercetin	308-317	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	129-138
30637814-3	2019	Moreover, it exhibited significantly (p &lt; 0.05) stronger inhibitory effect on nuclear translocation of nuclear factor-kappaB (NF-kappaB) by suppressing the phosphorylation of NF-kappaB p65 and p50 submits and on the phosphorylation of ETS domain-containing protein and c-Jun N-terminal kinase than any of quercetin or catechin alone.	Quercetin	308-317	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	178-187
30637814-4	2019	Besides, the cotreatment of quercetin with catechin significantly (p &lt; 0.05) restored the impaired expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and some downstream effectors (IRAK1, TRAF6, and TAK1).	Quercetin	28-37	toll-like receptor 4	Mus musculus	116-136
30637814-4	2019	Besides, the cotreatment of quercetin with catechin significantly (p &lt; 0.05) restored the impaired expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and some downstream effectors (IRAK1, TRAF6, and TAK1).	Quercetin	28-37	interleukin-1 receptor-associated kinase 1	Mus musculus	219-224
30637814-4	2019	Besides, the cotreatment of quercetin with catechin significantly (p &lt; 0.05) restored the impaired expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and some downstream effectors (IRAK1, TRAF6, and TAK1).	Quercetin	28-37	TNF receptor-associated factor 6	Mus musculus	226-231
30637814-4	2019	Besides, the cotreatment of quercetin with catechin significantly (p &lt; 0.05) restored the impaired expression of toll-like receptor 4, myeloid differentiation primary response gene 88, and some downstream effectors (IRAK1, TRAF6, and TAK1).	Quercetin	28-37	mitogen-activated protein kinase kinase kinase 7	Mus musculus	237-241
30637814-5	2019	These results suggest that quercetin and catechin possessed synergistic anti-inflammatory effects, which may be attributed to their roles in suppressing the activation of TLR4-MyD88-mediated NF-kappaB and mitogen-activated protein kinases signaling pathways.	Quercetin	27-36	toll-like receptor 4	Mus musculus	171-175
30637814-5	2019	These results suggest that quercetin and catechin possessed synergistic anti-inflammatory effects, which may be attributed to their roles in suppressing the activation of TLR4-MyD88-mediated NF-kappaB and mitogen-activated protein kinases signaling pathways.	Quercetin	27-36	myeloid differentiation primary response gene 88	Mus musculus	176-181
30637814-5	2019	These results suggest that quercetin and catechin possessed synergistic anti-inflammatory effects, which may be attributed to their roles in suppressing the activation of TLR4-MyD88-mediated NF-kappaB and mitogen-activated protein kinases signaling pathways.	Quercetin	27-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	191-200
30899368-0	2019	The IRE1alpha-XBP1 pathway function in hypoxia-induced pulmonary vascular remodeling, is upregulated by quercetin, inhibits apoptosis and partially reverses the effect of quercetin in PASMCs.	Quercetin	104-113	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	4-18
32454696-9	2019	Quercetin and monochloropivaloylquercetin treatment alleviated neuroinflammatory responses in microglial cells, by decreasing COX-2 mRNA expression.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	126-131
30804434-4	2019	We found that 0.1 nM and 1 nM quercetin or 1 nM isorhamnetin significantly increased glucose uptake via translocation of glucose transporter type 4 (GLUT4) to the plasma membrane of L6 myotubes.	Quercetin	30-39	solute carrier family 2 member 4	Homo sapiens	121-147
30804434-4	2019	We found that 0.1 nM and 1 nM quercetin or 1 nM isorhamnetin significantly increased glucose uptake via translocation of glucose transporter type 4 (GLUT4) to the plasma membrane of L6 myotubes.	Quercetin	30-39	solute carrier family 2 member 4	Homo sapiens	149-154
30804434-5	2019	Quercetin principally activated the CaMKKbeta/AMPK signalling pathway at these concentrations, but also activated IRS1/PI3K/Akt signalling at 10 nM.	Quercetin	0-9	insulin receptor substrate 1	Homo sapiens	114-118
30804434-5	2019	Quercetin principally activated the CaMKKbeta/AMPK signalling pathway at these concentrations, but also activated IRS1/PI3K/Akt signalling at 10 nM.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	124-127
30804434-7	2019	Treatment with siAMPKalpha and siJAK2 abolished quercetin- and isorhamnetin-induced GLUT4 translocation, respectively.	Quercetin	48-57	solute carrier family 2 member 4	Homo sapiens	84-89
30804434-9	2019	Thus, quercetin preferably activated the AMPK pathway and, accordingly, stimulated IRS1/PI3K/Akt signalling, while isorhamnetin activated the JAK2/STAT pathway.	Quercetin	6-15	insulin receptor substrate 1	Homo sapiens	83-87
30804434-9	2019	Thus, quercetin preferably activated the AMPK pathway and, accordingly, stimulated IRS1/PI3K/Akt signalling, while isorhamnetin activated the JAK2/STAT pathway.	Quercetin	6-15	AKT serine/threonine kinase 1	Homo sapiens	93-96
30804434-12	2019	In conclusion, at low-concentration ranges, quercetin and isorhamnetin promote glucose uptake by increasing GLUT4 translocation via different signalling pathways in skeletal muscle cells; thus, these compounds may possess beneficial functions for maintaining glucose homeostasis by preventing hyperglycaemia at physiological concentrations.	Quercetin	44-53	solute carrier family 2 member 4	Homo sapiens	108-113
30795510-3	2019	DHA and quercetin can individually suppress lipopolysaccharide (LPS)-induced oxidative/inflammatory responses and enhance the antioxidative stress pathway involving nuclear factor erythroid-2 related factor 2 (Nrf2).	Quercetin	8-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	165-208
30795510-3	2019	DHA and quercetin can individually suppress lipopolysaccharide (LPS)-induced oxidative/inflammatory responses and enhance the antioxidative stress pathway involving nuclear factor erythroid-2 related factor 2 (Nrf2).	Quercetin	8-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	210-214
30795510-6	2019	Results showed that low concentrations of quercetin (2.5 microM), in combination with DHA (10 microM), could more effectively enhance the expression of Nrf2 and heme oxygenase 1 (HO-1), and suppress LPS-induced nitric oxide, tumor necrosis factor-alpha, phospho-cytosolic phospholipase A2, reactive oxygen species, and 4-hydroxynonenal, as compared to the same levels of DHA or quercetin alone.	Quercetin	42-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	152-156
30795510-6	2019	Results showed that low concentrations of quercetin (2.5 microM), in combination with DHA (10 microM), could more effectively enhance the expression of Nrf2 and heme oxygenase 1 (HO-1), and suppress LPS-induced nitric oxide, tumor necrosis factor-alpha, phospho-cytosolic phospholipase A2, reactive oxygen species, and 4-hydroxynonenal, as compared to the same levels of DHA or quercetin alone.	Quercetin	42-51	heme oxygenase 1	Mus musculus	161-177
30795510-6	2019	Results showed that low concentrations of quercetin (2.5 microM), in combination with DHA (10 microM), could more effectively enhance the expression of Nrf2 and heme oxygenase 1 (HO-1), and suppress LPS-induced nitric oxide, tumor necrosis factor-alpha, phospho-cytosolic phospholipase A2, reactive oxygen species, and 4-hydroxynonenal, as compared to the same levels of DHA or quercetin alone.	Quercetin	42-51	tumor necrosis factor	Mus musculus	225-252
30899368-0	2019	The IRE1alpha-XBP1 pathway function in hypoxia-induced pulmonary vascular remodeling, is upregulated by quercetin, inhibits apoptosis and partially reverses the effect of quercetin in PASMCs.	Quercetin	171-180	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	4-18
30899368-7	2019	We demonstrated that quercetin evoked excessive GRP78 expression in hypoxic PASMCs compared with hypoxia alone by evaluating the expression of GRP78.	Quercetin	21-30	heat shock protein family A (Hsp70) member 5	Homo sapiens	48-53
30899368-7	2019	We demonstrated that quercetin evoked excessive GRP78 expression in hypoxic PASMCs compared with hypoxia alone by evaluating the expression of GRP78.	Quercetin	21-30	heat shock protein family A (Hsp70) member 5	Homo sapiens	143-148
30899368-8	2019	The expression of IRE1alpha and XBP1s, a cleavage form of XBP1u, was upregulated by quercetin in a dose-dependent manner.	Quercetin	84-93	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	18-27
30576699-3	2019	AIM: The present study aimed to investigate the effectiveness of combining quercetin with sitagliptin; a selective dipeptidyl peptidase-IV (DPP-IV) inhibitor, in the management of streptozotocin (STZ)-induced diabetic rats.	Quercetin	75-84	dipeptidylpeptidase 4	Rattus norvegicus	140-146
30624931-3	2019	Herein, we demonstrate that both kinases are inhibited by quercetin and 16 related flavonoids; IP6K is the preferred target.	Quercetin	58-67	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	95-99
30805562-8	2019	In murine C2C12 myotubes, quercetin elevated the phosphorylation of Akt, which are downstream of the myostatin pathway, as well as expression of atrogenes.	Quercetin	26-35	thymoma viral proto-oncogene 1	Mus musculus	68-71
30805562-8	2019	In murine C2C12 myotubes, quercetin elevated the phosphorylation of Akt, which are downstream of the myostatin pathway, as well as expression of atrogenes.	Quercetin	26-35	myostatin	Mus musculus	101-110
30368985-5	2019	The results showed that quercetin decreased the expression of BiP and C/EBP-homologous protein, the ER stress marker genes along with downregulation of tumor necrosis factor-alpha, JNK in irradiated DRG neurons.	Quercetin	24-33	growth differentiation factor 10	Homo sapiens	62-65
30203888-0	2019	Quercetin preferentially induces apoptosis in KRAS-mutant colorectal cancer cells via JNK signaling pathways.	Quercetin	0-9	KRAS proto-oncogene, GTPase	Homo sapiens	46-50
30203888-0	2019	Quercetin preferentially induces apoptosis in KRAS-mutant colorectal cancer cells via JNK signaling pathways.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	86-89
30203888-7	2019	The data revealed that KRAS-mutant cells were more sensitive to quercetin-induced apoptosis than wild-type cells.	Quercetin	64-73	KRAS proto-oncogene, GTPase	Homo sapiens	23-27
30203888-9	2019	In addition, quercetin selectively activated the c-Jun N-terminal kinase (JNK) pathway in KRAS-mutant cells, while inhibition of phospho-JNK by SP600125 blocked quercetin-induced apoptosis.	Quercetin	13-22	mitogen-activated protein kinase 8	Homo sapiens	49-72
30203888-9	2019	In addition, quercetin selectively activated the c-Jun N-terminal kinase (JNK) pathway in KRAS-mutant cells, while inhibition of phospho-JNK by SP600125 blocked quercetin-induced apoptosis.	Quercetin	13-22	mitogen-activated protein kinase 8	Homo sapiens	74-77
30203888-9	2019	In addition, quercetin selectively activated the c-Jun N-terminal kinase (JNK) pathway in KRAS-mutant cells, while inhibition of phospho-JNK by SP600125 blocked quercetin-induced apoptosis.	Quercetin	13-22	KRAS proto-oncogene, GTPase	Homo sapiens	90-94
30203888-9	2019	In addition, quercetin selectively activated the c-Jun N-terminal kinase (JNK) pathway in KRAS-mutant cells, while inhibition of phospho-JNK by SP600125 blocked quercetin-induced apoptosis.	Quercetin	161-170	mitogen-activated protein kinase 8	Homo sapiens	74-77
30203888-9	2019	In addition, quercetin selectively activated the c-Jun N-terminal kinase (JNK) pathway in KRAS-mutant cells, while inhibition of phospho-JNK by SP600125 blocked quercetin-induced apoptosis.	Quercetin	161-170	KRAS proto-oncogene, GTPase	Homo sapiens	90-94
30203888-9	2019	In addition, quercetin selectively activated the c-Jun N-terminal kinase (JNK) pathway in KRAS-mutant cells, while inhibition of phospho-JNK by SP600125 blocked quercetin-induced apoptosis.	Quercetin	161-170	mitogen-activated protein kinase 8	Homo sapiens	137-140
30741930-7	2019	More importantly, we revealed that luteolin, quercetin, and myricetin selectively downregulated the phosphorylation of Smad2/3 in TGF-beta/Smads signaling via binding to activin receptor-like kinase 5 (ALK5) and impairing its catalytic activity.	Quercetin	45-54	SMAD family member 2	Homo sapiens	119-126
30741930-7	2019	More importantly, we revealed that luteolin, quercetin, and myricetin selectively downregulated the phosphorylation of Smad2/3 in TGF-beta/Smads signaling via binding to activin receptor-like kinase 5 (ALK5) and impairing its catalytic activity.	Quercetin	45-54	transforming growth factor alpha	Homo sapiens	130-138
30741930-7	2019	More importantly, we revealed that luteolin, quercetin, and myricetin selectively downregulated the phosphorylation of Smad2/3 in TGF-beta/Smads signaling via binding to activin receptor-like kinase 5 (ALK5) and impairing its catalytic activity.	Quercetin	45-54	transforming growth factor beta receptor 1	Homo sapiens	170-200
30741930-7	2019	More importantly, we revealed that luteolin, quercetin, and myricetin selectively downregulated the phosphorylation of Smad2/3 in TGF-beta/Smads signaling via binding to activin receptor-like kinase 5 (ALK5) and impairing its catalytic activity.	Quercetin	45-54	transforming growth factor beta receptor 1	Homo sapiens	202-206
30392096-7	2019	All prepared compounds exhibit antioxidant activity, in particular quercetin derivative containing Met-enkephalin.	Quercetin	67-76	proopiomelanocortin	Homo sapiens	99-113
30203888-10	2019	The results of the present study suggest that treatment with quercetin, a common flavonoid in plants, is potentially a useful strategy for the treatment of CRCs carrying KRAS mutations.	Quercetin	61-70	KRAS proto-oncogene, GTPase	Homo sapiens	170-174
30368985-5	2019	The results showed that quercetin decreased the expression of BiP and C/EBP-homologous protein, the ER stress marker genes along with downregulation of tumor necrosis factor-alpha, JNK in irradiated DRG neurons.	Quercetin	24-33	tumor necrosis factor	Homo sapiens	152-179
30368985-5	2019	The results showed that quercetin decreased the expression of BiP and C/EBP-homologous protein, the ER stress marker genes along with downregulation of tumor necrosis factor-alpha, JNK in irradiated DRG neurons.	Quercetin	24-33	mitogen-activated protein kinase 8	Homo sapiens	181-184
30704023-1	2019	The aim of this study was to analyze the binding interactions between a common antihypertensive drug (amlodipine besylate-AML) and the widely distributed plant flavonoid quercetin (Q), in the presence of human serum albumin (HSA).	Quercetin	170-179	albumin	Homo sapiens	210-223
30704023-0	2019	Study of Interactions between Amlodipine and Quercetin on Human Serum Albumin: Spectroscopic and Modeling Approaches.	Quercetin	45-54	albumin	Homo sapiens	64-77
30596535-6	2019	We found that IL-17 stimulated RA-FLS to produce RANKL and quercetin decreased the IL-17-induced RANKL protein levels.	Quercetin	59-68	interleukin 17A	Homo sapiens	14-19
30596535-6	2019	We found that IL-17 stimulated RA-FLS to produce RANKL and quercetin decreased the IL-17-induced RANKL protein levels.	Quercetin	59-68	interleukin 17A	Homo sapiens	83-88
30596535-6	2019	We found that IL-17 stimulated RA-FLS to produce RANKL and quercetin decreased the IL-17-induced RANKL protein levels.	Quercetin	59-68	TNF superfamily member 11	Homo sapiens	97-102
30596535-7	2019	Quercetin decreased the IL-17-produced activation of mammalian target of rapamycin, extracellular signal-regulated kinase and inhibitor of kappa B-alpha.	Quercetin	0-9	interleukin 17A	Homo sapiens	24-29
30596535-7	2019	Quercetin decreased the IL-17-produced activation of mammalian target of rapamycin, extracellular signal-regulated kinase and inhibitor of kappa B-alpha.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	53-82
30596535-8	2019	When monocytes were stimulated with IL-17, macrophage colony-stimulating factor or RANKL, mature osteoclasts were formed, and quercetin decreased this osteoclastogenesis.	Quercetin	126-135	interleukin 17A	Homo sapiens	36-41
30596535-8	2019	When monocytes were stimulated with IL-17, macrophage colony-stimulating factor or RANKL, mature osteoclasts were formed, and quercetin decreased this osteoclastogenesis.	Quercetin	126-135	TNF superfamily member 11	Homo sapiens	83-88
30596535-9	2019	When monocytes were cultured with IL-17-prestimulated RA-FLS or Th17 cells, osteoclasts were produced, and quercetin decreased this osteoclast differentiation.	Quercetin	107-116	interleukin 17A	Homo sapiens	34-39
30596535-10	2019	In Th17-differentiation conditions, quercetin suppressed Th17 cell and the production of IL-17, but quercetin did not affect Treg cells.	Quercetin	36-45	interleukin 17A	Homo sapiens	89-94
30596535-11	2019	Quercetin inhibits IL-17-stimulated RANKL production in RA-FLS and IL-17-stimulated osteoclast formation.	Quercetin	0-9	interleukin 17A	Homo sapiens	19-24
30596535-11	2019	Quercetin inhibits IL-17-stimulated RANKL production in RA-FLS and IL-17-stimulated osteoclast formation.	Quercetin	0-9	TNF superfamily member 11	Homo sapiens	36-41
30596535-11	2019	Quercetin inhibits IL-17-stimulated RANKL production in RA-FLS and IL-17-stimulated osteoclast formation.	Quercetin	0-9	interleukin 17A	Homo sapiens	67-72
30847127-0	2019	Effects of chlorogenic acid, epicatechin gallate, and quercetin on mucin expression and secretion in the Caco-2/HT29-MTX cell model.	Quercetin	54-63	LOC100508689	Homo sapiens	67-72
30847127-7	2019	Statistically significant up-regulation of MUC17 was observed following incubation with epicatechin gallate and quercetin.	Quercetin	112-121	mucin 17, cell surface associated	Homo sapiens	43-48
30691220-4	2019	This study aimed to validate the DPP-4 inhibitory activity of clerodane diterpene 16-hydroxycleroda-3,13-dien-15,16-olide (HCD) from Polyalthia longifolia, rutin, quercetin, and berberine, previously selected through molecular docking.	Quercetin	163-172	dipeptidyl peptidase 4	Homo sapiens	33-38
30700983-5	2018	Pre-treatment with quercetin, known for its anti-oxidant and anti-inflammatory activity, reduced bacterial infection to Caco-2 cells, which might be partially via interfering integrin beta1 and FAK association augmented by E. coli O157:H7.	Quercetin	19-28	integrin subunit beta 1	Homo sapiens	175-189
30678660-10	2019	Significant reduction in CYP2C8, 2C9, and 3A4 was seen upon concomitant use of warfarin with ellagic acid, guava leaves and quercetin, unlike pomegranate that insignificantly affected CYP activities.	Quercetin	124-133	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	25-28
30700983-5	2018	Pre-treatment with quercetin, known for its anti-oxidant and anti-inflammatory activity, reduced bacterial infection to Caco-2 cells, which might be partially via interfering integrin beta1 and FAK association augmented by E. coli O157:H7.	Quercetin	19-28	protein tyrosine kinase 2	Homo sapiens	194-197
30700983-8	2018	Quercetin inhibits bacterial infection possibly by blocking the interaction between E. coli O157:H7 and integrin beta1.	Quercetin	0-9	integrin subunit beta 1	Homo sapiens	104-118
29921882-8	2019	Pre-administration of quercetin (40, 80 mg/kg) effectively inhibited TSN-induced liver oxidative injury and reversed the decreased expression of Nrf2 and GCLC/GCLM in vivo and in vitro.	Quercetin	22-31	glutamate-cysteine ligase catalytic subunit	Homo sapiens	154-158
30172871-2	2019	The binding capacity of hesperetin (HES), luteolin (LUT), quercetin (QUE), catechin (CAT) and rutin (RUT) with pancreatic alpha-amylase were evaluated, using UV-Vis spectroscopy, fluorescence and molecular docking.	Quercetin	58-67	amylase alpha 2A	Homo sapiens	111-135
30172871-2	2019	The binding capacity of hesperetin (HES), luteolin (LUT), quercetin (QUE), catechin (CAT) and rutin (RUT) with pancreatic alpha-amylase were evaluated, using UV-Vis spectroscopy, fluorescence and molecular docking.	Quercetin	69-72	amylase alpha 2A	Homo sapiens	111-135
29921882-0	2019	Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
29921882-0	2019	Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway.	Quercetin	0-9	glutamate-cysteine ligase catalytic subunit	Homo sapiens	82-85
29921882-8	2019	Pre-administration of quercetin (40, 80 mg/kg) effectively inhibited TSN-induced liver oxidative injury and reversed the decreased expression of Nrf2 and GCLC/GCLM in vivo and in vitro.	Quercetin	22-31	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
29921882-8	2019	Pre-administration of quercetin (40, 80 mg/kg) effectively inhibited TSN-induced liver oxidative injury and reversed the decreased expression of Nrf2 and GCLC/GCLM in vivo and in vitro.	Quercetin	22-31	glutamate-cysteine ligase modifier subunit	Homo sapiens	159-163
29921882-9	2019	In addition, the quercetin-provided protection against TSN-induced hepatotoxicity was diminished in Nrf2 knock-out mice.	Quercetin	17-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	100-104
29921882-11	2019	Quercetin attenuates TSN-induced hepatotoxicity by inducing the Nrf2/GCL/GSH antioxidant signaling pathway.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
29921882-11	2019	Quercetin attenuates TSN-induced hepatotoxicity by inducing the Nrf2/GCL/GSH antioxidant signaling pathway.	Quercetin	0-9	glutamate-cysteine ligase catalytic subunit	Homo sapiens	69-72
31179723-8	2019	Multiple apoptosis related genes including p53, Bax and Fas were upregulated by quercetin in tumor tissue and the ratio of Bax/Bcl-2 was increased accordingly.	Quercetin	80-89	transformation related protein 53, pseudogene	Mus musculus	43-46
31179723-8	2019	Multiple apoptosis related genes including p53, Bax and Fas were upregulated by quercetin in tumor tissue and the ratio of Bax/Bcl-2 was increased accordingly.	Quercetin	80-89	BCL2-associated X protein	Mus musculus	48-51
31179723-9	2019	Our results demonstrated that quercetin, as the main effective component of the YYQFT, has potent inhibitory activity on non-small cell lung cancer by regulating the ratio of Bax/Bcl-2.	Quercetin	30-39	BCL2-associated X protein	Mus musculus	175-178
31179723-9	2019	Our results demonstrated that quercetin, as the main effective component of the YYQFT, has potent inhibitory activity on non-small cell lung cancer by regulating the ratio of Bax/Bcl-2.	Quercetin	30-39	B cell leukemia/lymphoma 2	Mus musculus	179-184
30508524-7	2019	On the other hand, numerous anti-inflammatory AHR agonists have been identified including bilirubin and quercetin.	Quercetin	104-113	aryl hydrocarbon receptor	Homo sapiens	46-49
30697276-13	2019	In normal and diabetic rat sperm incubated with H2O2, a further increase in MDA and further decreases in SOD, CAT and GPx were observed, and these were ameliorated by quercetin treatment.	Quercetin	167-176	catalase	Rattus norvegicus	110-113
30109946-6	2019	Although quercetin alone was not proapoptotic, it abolished the resistance to FasL- or TRAIL-induced apoptosis in IPF fibroblasts.	Quercetin	9-18	Fas ligand	Homo sapiens	78-82
30109946-6	2019	Although quercetin alone was not proapoptotic, it abolished the resistance to FasL- or TRAIL-induced apoptosis in IPF fibroblasts.	Quercetin	9-18	TNF superfamily member 10	Homo sapiens	87-92
30109946-7	2019	Mechanistically, quercetin upregulated FasL receptor and caveolin-1 expression and modulated AKT activation.	Quercetin	17-26	caveolin 1	Homo sapiens	57-67
30109946-7	2019	Mechanistically, quercetin upregulated FasL receptor and caveolin-1 expression and modulated AKT activation.	Quercetin	17-26	AKT serine/threonine kinase 1	Homo sapiens	93-96
30109946-8	2019	In vivo quercetin reversed bleomycin-induced pulmonary fibrosis and attenuated lethality, weight loss, and the expression of pulmonary senescence markers p21 and p19-ARF and senescence-associated secretory phenotype in aged mice.	Quercetin	8-17	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	154-157
30109946-8	2019	In vivo quercetin reversed bleomycin-induced pulmonary fibrosis and attenuated lethality, weight loss, and the expression of pulmonary senescence markers p21 and p19-ARF and senescence-associated secretory phenotype in aged mice.	Quercetin	8-17	interleukin 23, alpha subunit p19	Mus musculus	162-165
30109946-9	2019	Collectively, these data indicate that quercetin reverses the resistance to death ligand-induced apoptosis by promoting FasL receptor and caveolin-1 expression and inhibiting AKT activation, thus mitigating the progression of established pulmonary fibrosis in aged mice.	Quercetin	39-48	caveolin 1, caveolae protein	Mus musculus	138-148
30109946-9	2019	Collectively, these data indicate that quercetin reverses the resistance to death ligand-induced apoptosis by promoting FasL receptor and caveolin-1 expression and inhibiting AKT activation, thus mitigating the progression of established pulmonary fibrosis in aged mice.	Quercetin	39-48	thymoma viral proto-oncogene 1	Mus musculus	175-178
31362681-0	2019	Quercetin Promotes Cell Cycle Arrest and Apoptosis and Attenuates the Proliferation of Human Chronic Myeloid Leukemia Cell Line-K562 Through Interaction with HSPs (70 and 90), MAT2A and FOXM1.	Quercetin	0-9	methionine adenosyltransferase 2A	Homo sapiens	176-181
31362681-0	2019	Quercetin Promotes Cell Cycle Arrest and Apoptosis and Attenuates the Proliferation of Human Chronic Myeloid Leukemia Cell Line-K562 Through Interaction with HSPs (70 and 90), MAT2A and FOXM1.	Quercetin	0-9	forkhead box M1	Homo sapiens	186-191
31362681-8	2019	On the other hand, RT-PCR results showed a reduction in some of the candidate genes expression, especially HSP70, Bcl-X(L) and FOXM1, when cells were treated with quercetin 40 and 80microM.	Quercetin	163-172	BCL2 like 1	Homo sapiens	114-122
31362681-8	2019	On the other hand, RT-PCR results showed a reduction in some of the candidate genes expression, especially HSP70, Bcl-X(L) and FOXM1, when cells were treated with quercetin 40 and 80microM.	Quercetin	163-172	forkhead box M1	Homo sapiens	127-132
31362681-9	2019	Also, Bax, caspase-3 and caspase-8 expression was significantly improved in K-562 cells upon quercetin exposure.	Quercetin	93-102	BCL2 associated X, apoptosis regulator	Homo sapiens	6-9
31362681-9	2019	Also, Bax, caspase-3 and caspase-8 expression was significantly improved in K-562 cells upon quercetin exposure.	Quercetin	93-102	caspase 3	Homo sapiens	11-20
31362681-9	2019	Also, Bax, caspase-3 and caspase-8 expression was significantly improved in K-562 cells upon quercetin exposure.	Quercetin	93-102	caspase 8	Homo sapiens	25-34
30551472-0	2019	Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/ARE/glyoxalase-1 pathway mediated by phosphorylation regulation.	Quercetin	19-28	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
30551472-6	2019	Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling.	Quercetin	11-20	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52
30551472-2	2019	This study was designed to investigate whether quercetin showed neuroprotection on central neurons against chronic high glucose through the enhancement of Nrf2/ARE/glyoxalase 1 (Glo-1) pathway.	Quercetin	47-56	NFE2 like bZIP transcription factor 2	Homo sapiens	155-159
30551472-6	2019	Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling.	Quercetin	11-20	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
30551472-6	2019	Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling.	Quercetin	11-20	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
30551472-6	2019	Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling.	Quercetin	11-20	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
30551472-7	2019	Moreover, Nrf2/ARE pathway was activated after pretreatment with a PKC activator, p38 MAPK inhibitor, or GSK-3beta inhibitor under the condition of HG, and quercetin addition further strengthened this pathway; however, PKC inhibition or GSK-3beta activation pretreatment reversed the effects of quercetin on the protein expression of gamma-GCS in the HG condition.	Quercetin	156-165	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
30551472-7	2019	Moreover, Nrf2/ARE pathway was activated after pretreatment with a PKC activator, p38 MAPK inhibitor, or GSK-3beta inhibitor under the condition of HG, and quercetin addition further strengthened this pathway; however, PKC inhibition or GSK-3beta activation pretreatment reversed the effects of quercetin on the protein expression of gamma-GCS in the HG condition.	Quercetin	156-165	glycogen synthase kinase 3 beta	Homo sapiens	105-114
30551472-2	2019	This study was designed to investigate whether quercetin showed neuroprotection on central neurons against chronic high glucose through the enhancement of Nrf2/ARE/glyoxalase 1 (Glo-1) pathway.	Quercetin	47-56	glyoxalase I	Homo sapiens	178-183
30551472-7	2019	Moreover, Nrf2/ARE pathway was activated after pretreatment with a PKC activator, p38 MAPK inhibitor, or GSK-3beta inhibitor under the condition of HG, and quercetin addition further strengthened this pathway; however, PKC inhibition or GSK-3beta activation pretreatment reversed the effects of quercetin on the protein expression of gamma-GCS in the HG condition.	Quercetin	156-165	glycogen synthase kinase 3 beta	Homo sapiens	237-246
30551472-7	2019	Moreover, Nrf2/ARE pathway was activated after pretreatment with a PKC activator, p38 MAPK inhibitor, or GSK-3beta inhibitor under the condition of HG, and quercetin addition further strengthened this pathway; however, PKC inhibition or GSK-3beta activation pretreatment reversed the effects of quercetin on the protein expression of gamma-GCS in the HG condition.	Quercetin	295-304	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
30551472-5	2019	We found quercetin and sulforaphane increased cell viability, and enhanced Glo-1 functions (Glo-1 activity, the reduced glutathione and advanced glycation end-products levels) as well as Glo-1 protein and mRNA levels in SH-SY5Y cells cultured with HG.	Quercetin	9-18	glyoxalase I	Homo sapiens	75-80
30551472-8	2019	In summary, quercetin exerts the neuroprotection by enhancing Glo-1 functions in central neurons under chronic HG condition, which may be mediated by activation of Nrf2/ARE pathway; furthermore, the increased Nrf2 phosphorylation mediated by PKC activation and/or GSK-3beta inhibition may involve in the activation of Nrf2/ARE pathway.	Quercetin	12-21	glyoxalase I	Homo sapiens	62-67
30551472-8	2019	In summary, quercetin exerts the neuroprotection by enhancing Glo-1 functions in central neurons under chronic HG condition, which may be mediated by activation of Nrf2/ARE pathway; furthermore, the increased Nrf2 phosphorylation mediated by PKC activation and/or GSK-3beta inhibition may involve in the activation of Nrf2/ARE pathway.	Quercetin	12-21	NFE2 like bZIP transcription factor 2	Homo sapiens	164-168
30551472-5	2019	We found quercetin and sulforaphane increased cell viability, and enhanced Glo-1 functions (Glo-1 activity, the reduced glutathione and advanced glycation end-products levels) as well as Glo-1 protein and mRNA levels in SH-SY5Y cells cultured with HG.	Quercetin	9-18	glyoxalase I	Homo sapiens	92-97
30551472-8	2019	In summary, quercetin exerts the neuroprotection by enhancing Glo-1 functions in central neurons under chronic HG condition, which may be mediated by activation of Nrf2/ARE pathway; furthermore, the increased Nrf2 phosphorylation mediated by PKC activation and/or GSK-3beta inhibition may involve in the activation of Nrf2/ARE pathway.	Quercetin	12-21	NFE2 like bZIP transcription factor 2	Homo sapiens	209-213
30551472-8	2019	In summary, quercetin exerts the neuroprotection by enhancing Glo-1 functions in central neurons under chronic HG condition, which may be mediated by activation of Nrf2/ARE pathway; furthermore, the increased Nrf2 phosphorylation mediated by PKC activation and/or GSK-3beta inhibition may involve in the activation of Nrf2/ARE pathway.	Quercetin	12-21	glycogen synthase kinase 3 beta	Homo sapiens	264-273
30551472-5	2019	We found quercetin and sulforaphane increased cell viability, and enhanced Glo-1 functions (Glo-1 activity, the reduced glutathione and advanced glycation end-products levels) as well as Glo-1 protein and mRNA levels in SH-SY5Y cells cultured with HG.	Quercetin	9-18	glyoxalase I	Homo sapiens	92-97
30551472-8	2019	In summary, quercetin exerts the neuroprotection by enhancing Glo-1 functions in central neurons under chronic HG condition, which may be mediated by activation of Nrf2/ARE pathway; furthermore, the increased Nrf2 phosphorylation mediated by PKC activation and/or GSK-3beta inhibition may involve in the activation of Nrf2/ARE pathway.	Quercetin	12-21	NFE2 like bZIP transcription factor 2	Homo sapiens	209-213
30318192-0	2019	Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug.	Quercetin	16-25	ATP binding cassette subfamily B member 1	Homo sapiens	65-69
31223026-8	2019	The expression levels of BAD and p53 genes decreased by combined treatment with quercetin and selenium while showing synergistic effects in terms of gene expression.	Quercetin	80-89	tumor protein p53	Homo sapiens	33-36
31573877-12	2019	These indicated that quercetin produced the therapeutic effects against cardiovascular disease by systemically and holistically regulating many signaling pathways, including Fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, MAPK signaling pathway, IL-17 signaling pathway and PI3K-Akt signaling pathway.	Quercetin	21-30	tumor necrosis factor	Homo sapiens	268-271
30351529-9	2019	S. lentiscifolius bark extract has antioxidant activity and inhibitory effect on HSR probably due to the presence of polyphenols as the flavonoids quercetin and kaempferol.	Quercetin	147-156	HSR	Homo sapiens	81-84
30543170-5	2019	RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors.	Quercetin	67-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-32
30543170-5	2019	RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors.	Quercetin	67-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
30747068-2	2019	OBJECTIVE: A series of quercetin based derivatives was designed, synthesized, and evaluated as novel multifunctional agents against monoamine oxidase A and B with antioxidant potential.	Quercetin	23-32	monoamine oxidase A	Homo sapiens	132-151
31613724-7	2019	Generally, the aglycones quercetin, myricetin, fisetin or apigenin have been reported to strongly inhibit GLUT2, while quercetin-3-O-glycoside has been demonstrated to be more effective in SGLT1.	Quercetin	25-34	solute carrier family 2 member 2	Homo sapiens	106-111
30747068-9	2019	Moreover, the mechanistic insight into the docking poses was also explored by binding interactions of quercetin based derivatives inside the dynamic site of hMAO-A and hMAO-B.	Quercetin	102-111	monoamine oxidase A	Homo sapiens	157-174
30815381-0	2019	Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats.	Quercetin	0-9	matrix metallopeptidase 9	Rattus norvegicus	55-81
30413935-2	2019	Our previous findings suggest the extensive mechanism of quercetin (QUE) mediated regression of cell survival, cell proliferation, oxidative stress, inflammation, and angiogenesis via modulating PI3K and PKC signaling in lymphoma as well as hepatocellular carcinoma.	Quercetin	57-66	protein kinase C alpha	Homo sapiens	204-207
30413935-2	2019	Our previous findings suggest the extensive mechanism of quercetin (QUE) mediated regression of cell survival, cell proliferation, oxidative stress, inflammation, and angiogenesis via modulating PI3K and PKC signaling in lymphoma as well as hepatocellular carcinoma.	Quercetin	68-71	protein kinase C alpha	Homo sapiens	204-207
30471617-0	2019	Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCgamma-IP3R related Ca2+ fluctuations.	Quercetin	0-9	MAS related GPR family member X2	Homo sapiens	19-26
30471617-11	2019	In addition, Quercetin inhibited Mrgprx2-induced both calcium influx and pseudo-allergic reaction in HEK293 cells expressing Mrgprx2.	Quercetin	13-22	MAS related GPR family member X2	Homo sapiens	33-40
30471617-11	2019	In addition, Quercetin inhibited Mrgprx2-induced both calcium influx and pseudo-allergic reaction in HEK293 cells expressing Mrgprx2.	Quercetin	13-22	MAS related GPR family member X2	Homo sapiens	125-132
30471617-12	2019	C48/80, a histamine promoter, and Substance P (a neuropeptide) EC50 was higher when combined with Quercetin compared to the EC50 of these compounds alone, suggesting that Quercetin could inhibit Mrgprx2-induced pseudo-allergic reaction.	Quercetin	98-107	tachykinin precursor 1	Homo sapiens	34-45
30471617-12	2019	C48/80, a histamine promoter, and Substance P (a neuropeptide) EC50 was higher when combined with Quercetin compared to the EC50 of these compounds alone, suggesting that Quercetin could inhibit Mrgprx2-induced pseudo-allergic reaction.	Quercetin	98-107	MAS related GPR family member X2	Homo sapiens	195-202
30471617-12	2019	C48/80, a histamine promoter, and Substance P (a neuropeptide) EC50 was higher when combined with Quercetin compared to the EC50 of these compounds alone, suggesting that Quercetin could inhibit Mrgprx2-induced pseudo-allergic reaction.	Quercetin	171-180	tachykinin precursor 1	Homo sapiens	34-45
30471617-12	2019	C48/80, a histamine promoter, and Substance P (a neuropeptide) EC50 was higher when combined with Quercetin compared to the EC50 of these compounds alone, suggesting that Quercetin could inhibit Mrgprx2-induced pseudo-allergic reaction.	Quercetin	171-180	MAS related GPR family member X2	Homo sapiens	195-202
30471617-14	2019	In Mrgprx2 knockdown LAD2 cells, the effect of Quercetin (200 muM) reduced C48/80 induced calcium flux and the release of beta-hexosaminidase, histamine, MCP-1 and IL-8 compared with non-atopic control (NC) transfected LAD2 human mast cells, suggesting that Quercetin anti-pseudo-allergic effect was related to Mrgprx2.	Quercetin	47-56	MAS related GPR family member X2	Homo sapiens	3-10
30471617-14	2019	In Mrgprx2 knockdown LAD2 cells, the effect of Quercetin (200 muM) reduced C48/80 induced calcium flux and the release of beta-hexosaminidase, histamine, MCP-1 and IL-8 compared with non-atopic control (NC) transfected LAD2 human mast cells, suggesting that Quercetin anti-pseudo-allergic effect was related to Mrgprx2.	Quercetin	47-56	O-GlcNAcase	Homo sapiens	122-141
30471617-14	2019	In Mrgprx2 knockdown LAD2 cells, the effect of Quercetin (200 muM) reduced C48/80 induced calcium flux and the release of beta-hexosaminidase, histamine, MCP-1 and IL-8 compared with non-atopic control (NC) transfected LAD2 human mast cells, suggesting that Quercetin anti-pseudo-allergic effect was related to Mrgprx2.	Quercetin	47-56	C-C motif chemokine ligand 2	Homo sapiens	154-159
30471617-14	2019	In Mrgprx2 knockdown LAD2 cells, the effect of Quercetin (200 muM) reduced C48/80 induced calcium flux and the release of beta-hexosaminidase, histamine, MCP-1 and IL-8 compared with non-atopic control (NC) transfected LAD2 human mast cells, suggesting that Quercetin anti-pseudo-allergic effect was related to Mrgprx2.	Quercetin	47-56	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
30471617-14	2019	In Mrgprx2 knockdown LAD2 cells, the effect of Quercetin (200 muM) reduced C48/80 induced calcium flux and the release of beta-hexosaminidase, histamine, MCP-1 and IL-8 compared with non-atopic control (NC) transfected LAD2 human mast cells, suggesting that Quercetin anti-pseudo-allergic effect was related to Mrgprx2.	Quercetin	47-56	MAS related GPR family member X2	Homo sapiens	311-318
30471617-15	2019	The docking results showed that Quercetin had a good binding affinity with Mrgprx2 similar to the one of Substance P and C48/80.	Quercetin	32-41	MAS related GPR family member X2	Homo sapiens	75-82
30471617-15	2019	The docking results showed that Quercetin had a good binding affinity with Mrgprx2 similar to the one of Substance P and C48/80.	Quercetin	32-41	tachykinin precursor 1	Homo sapiens	105-116
30471617-16	2019	Therefore, Quercetin inhibited Mrgprx2-induced pseudo-allergic reaction via PLCgamma-IP3R associated Ca2+ fluctuations.	Quercetin	11-20	MAS related GPR family member X2	Homo sapiens	31-38
30471617-17	2019	Our results validated Quercetin as an effective small molecule inhibiting Mrgprx2-induced pseudo-allergic reaction via PLCgamma-IP3R associated Ca2+ fluctuations, thus highlighting a potential candidate to suppress Mrgprx2 induced pseudo-allergic related diseases.	Quercetin	22-31	MAS related GPR family member X2	Homo sapiens	74-81
30471617-17	2019	Our results validated Quercetin as an effective small molecule inhibiting Mrgprx2-induced pseudo-allergic reaction via PLCgamma-IP3R associated Ca2+ fluctuations, thus highlighting a potential candidate to suppress Mrgprx2 induced pseudo-allergic related diseases.	Quercetin	22-31	MAS related GPR family member X2	Homo sapiens	215-222
30815381-0	2019	Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats.	Quercetin	0-9	matrix metallopeptidase 13	Rattus norvegicus	83-176
30815381-1	2019	Prior study has shown that Ageratum conyzoides L. extract that containing quercetin has been proved to prevent inflammation and proteoglycan degradation by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase (MMP-9) expression.	Quercetin	74-83	matrix metallopeptidase 9	Rattus norvegicus	225-230
30815381-3	2019	The aim of this study was to prove the efficacy of quercetin-loaded lecithin-chitosan nanoparticles on the OA model rats by observed its effect on interleukin (IL-1) beta, MMP-9, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-5) expressions.	Quercetin	51-60	interleukin 1 beta	Rattus norvegicus	160-170
30815381-3	2019	The aim of this study was to prove the efficacy of quercetin-loaded lecithin-chitosan nanoparticles on the OA model rats by observed its effect on interleukin (IL-1) beta, MMP-9, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-5) expressions.	Quercetin	51-60	matrix metallopeptidase 9	Rattus norvegicus	172-177
30815381-3	2019	The aim of this study was to prove the efficacy of quercetin-loaded lecithin-chitosan nanoparticles on the OA model rats by observed its effect on interleukin (IL-1) beta, MMP-9, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-5) expressions.	Quercetin	51-60	matrix metallopeptidase 13	Rattus norvegicus	179-185
30815381-3	2019	The aim of this study was to prove the efficacy of quercetin-loaded lecithin-chitosan nanoparticles on the OA model rats by observed its effect on interleukin (IL-1) beta, MMP-9, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-5) expressions.	Quercetin	51-60	ADAM metallopeptidase with thrombospondin type 1 motif, 5	Rattus norvegicus	255-263
30815381-7	2019	Quercetin-loaded nanoparticle gel dose 1 (0.84 mg/g gel), dose 2 (1.68 mg/g gel), dose 3 (3.36 mg/g), and A. conyzoides L. extract gel could decreased the level of IL-1 beta, MMP-9, MMP-13, ADAMTS-5, and increasing color intensity significantly on histopathological observations on DMM and MIA-induced OA.	Quercetin	0-9	matrix metallopeptidase 9	Rattus norvegicus	175-180
30815381-7	2019	Quercetin-loaded nanoparticle gel dose 1 (0.84 mg/g gel), dose 2 (1.68 mg/g gel), dose 3 (3.36 mg/g), and A. conyzoides L. extract gel could decreased the level of IL-1 beta, MMP-9, MMP-13, ADAMTS-5, and increasing color intensity significantly on histopathological observations on DMM and MIA-induced OA.	Quercetin	0-9	matrix metallopeptidase 13	Rattus norvegicus	182-188
30815381-7	2019	Quercetin-loaded nanoparticle gel dose 1 (0.84 mg/g gel), dose 2 (1.68 mg/g gel), dose 3 (3.36 mg/g), and A. conyzoides L. extract gel could decreased the level of IL-1 beta, MMP-9, MMP-13, ADAMTS-5, and increasing color intensity significantly on histopathological observations on DMM and MIA-induced OA.	Quercetin	0-9	ADAM metallopeptidase with thrombospondin type 1 motif, 5	Rattus norvegicus	190-198
30519865-5	2019	The present study aimed to investigate effect of quercetin on mitochondrial functioning in MeCP2-deficient astrocytes.	Quercetin	49-58	methyl-CpG binding protein 2	Homo sapiens	91-96
30947605-6	2019	Quercetin did not have any influence on the number of granulosa cells containing caspase 3, but at the concentration 10 mumol L-1 it inhibited p53 occurrence.	Quercetin	0-9	tumor protein p53	Homo sapiens	143-146
30947605-7	2019	Results confirm the safety of quercetin in porcine ovarian granulosa cell model and further suggest its possible concentration-dependent influence on ovarian functions through pathway that may involve progesterone, cyclin B1 and p53.	Quercetin	30-39	cyclin B1	Homo sapiens	215-224
30947605-7	2019	Results confirm the safety of quercetin in porcine ovarian granulosa cell model and further suggest its possible concentration-dependent influence on ovarian functions through pathway that may involve progesterone, cyclin B1 and p53.	Quercetin	30-39	tumor protein p53	Homo sapiens	229-232
30519865-8	2019	Quercetin increased MeCP2 and normalized Uqcrc1 and Ndufv2 gene expression but did not modulate MeCP2 and Ndufv2 proteins expression.	Quercetin	0-9	methyl-CpG binding protein 2	Homo sapiens	20-25
30519865-8	2019	Quercetin increased MeCP2 and normalized Uqcrc1 and Ndufv2 gene expression but did not modulate MeCP2 and Ndufv2 proteins expression.	Quercetin	0-9	ubiquinol-cytochrome c reductase core protein 1	Homo sapiens	41-47
30359864-0	2019	Quercetin inhibits proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo.	Quercetin	0-9	cyclin D1	Homo sapiens	61-70
30519865-8	2019	Quercetin increased MeCP2 and normalized Uqcrc1 and Ndufv2 gene expression but did not modulate MeCP2 and Ndufv2 proteins expression.	Quercetin	0-9	NADH:ubiquinone oxidoreductase core subunit V2	Homo sapiens	52-58
30359864-8	2019	The mRNA expression of Ccnd1 significantly decreased in response to quercetin intraperitoneal injection when compared to that in vehicle-treated mice.	Quercetin	68-77	cyclin D1	Mus musculus	23-28
30359864-10	2019	Furthermore, the treatment of quercetin induced miR-503-5p, miR-1283, miR-3714 and miR-6867-5p related to CCND1 in both cell lines and also stimulated miR-503-5p and miR-546 expression in the mouse model.	Quercetin	30-39	cyclin D1	Mus musculus	106-111
31631752-8	2019	In addition, APAP significantly (p &lt; 0.05) modulated TNF-alpha, IL-6, MDA, SOD, GPx, and ALT biomarkers, which were completely protected by RES+QUR.	Quercetin	147-150	tumor necrosis factor	Rattus norvegicus	56-65
30359864-10	2019	Furthermore, the treatment of quercetin induced miR-503-5p, miR-1283, miR-3714 and miR-6867-5p related to CCND1 in both cell lines and also stimulated miR-503-5p and miR-546 expression in the mouse model.	Quercetin	30-39	microRNA 546	Mus musculus	166-173
30661409-1	2019	Quercetin, an antioxidant flavonoid, has been known that it can induce the cell cycle arrest and apoptosis of hepatocellular carcinoma (HCC) cells by the stabilization or induction of p53.	Quercetin	0-9	tumor protein p53	Homo sapiens	184-187
30661409-6	2019	This study demonstrates that the antiproliferative effect of quercetin on HCC cells can be mediated by reducing intracellular ROS, which is independent of p53 expression.	Quercetin	61-70	tumor protein p53	Homo sapiens	155-158
30103849-10	2019	PCOS resulted in a decrease in liver GK and an increase in liver HK specific activity, whereas quercetin increased both liver HK and GK activity.	Quercetin	95-104	glucokinase	Rattus norvegicus	133-135
30103849-11	2019	Our data also showed a significant reduction in uterine ERalpha and GLUT4 expression in the PCOS group, which was increased by quercetin.	Quercetin	127-136	estrogen receptor 1	Rattus norvegicus	56-63
30103849-11	2019	Our data also showed a significant reduction in uterine ERalpha and GLUT4 expression in the PCOS group, which was increased by quercetin.	Quercetin	127-136	solute carrier family 2 member 4	Rattus norvegicus	68-73
30103849-12	2019	A remarkable effect of quercetin was the intensive reduction of PCOS-IR and significant induction of uterine GLUT4 and ERalpha gene expression; it could thus be a possible effective treatment for PCOS and its complications, IR and infertility.	Quercetin	23-32	solute carrier family 2 member 4	Rattus norvegicus	109-114
30103849-12	2019	A remarkable effect of quercetin was the intensive reduction of PCOS-IR and significant induction of uterine GLUT4 and ERalpha gene expression; it could thus be a possible effective treatment for PCOS and its complications, IR and infertility.	Quercetin	23-32	estrogen receptor 1	Rattus norvegicus	119-126
30599890-0	2019	Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/beta-catenin signaling and apoptotic pathways in A375 cells.	Quercetin	13-22	catenin beta 1	Homo sapiens	115-127
30599890-10	2019	Further investigation of the mechanism of action of curcumin and quercetin in melanoma cells, A375, suggested that inhibition of cell proliferation occurred through down-regulation of Wnt/beta-catenin signaling pathway proteins, DVL2, beta-catenin, cyclin D1, Cox2, and Axin2.	Quercetin	65-74	catenin beta 1	Homo sapiens	188-200
30599890-10	2019	Further investigation of the mechanism of action of curcumin and quercetin in melanoma cells, A375, suggested that inhibition of cell proliferation occurred through down-regulation of Wnt/beta-catenin signaling pathway proteins, DVL2, beta-catenin, cyclin D1, Cox2, and Axin2.	Quercetin	65-74	catenin beta 1	Homo sapiens	235-247
30599890-11	2019	In addition, both curcumin and quercetin induced apoptosis by down-regulating BCL2 and inducing caspase 3/7 through PARP cleavage.	Quercetin	31-40	BCL2 apoptosis regulator	Homo sapiens	78-82
30599890-11	2019	In addition, both curcumin and quercetin induced apoptosis by down-regulating BCL2 and inducing caspase 3/7 through PARP cleavage.	Quercetin	31-40	caspase 3	Homo sapiens	96-105
30599890-11	2019	In addition, both curcumin and quercetin induced apoptosis by down-regulating BCL2 and inducing caspase 3/7 through PARP cleavage.	Quercetin	31-40	collagen type XI alpha 2 chain	Homo sapiens	116-120
31631752-8	2019	In addition, APAP significantly (p &lt; 0.05) modulated TNF-alpha, IL-6, MDA, SOD, GPx, and ALT biomarkers, which were completely protected by RES+QUR.	Quercetin	147-150	interleukin 6	Rattus norvegicus	67-71
30687400-4	2018	The present study investigated the potential of quercetin and synthetic 3-hydroxyflavone analogues to inhibit HDAC8 enzyme and evaluated their anticancer property.	Quercetin	48-57	histone deacetylase 8	Homo sapiens	110-115
30662665-0	2018	Sensitization of keloid fibroblasts by quercetin through the PI3K/Akt pathway is dependent on regulation of HIF-1alpha.	Quercetin	39-48	AKT serine/threonine kinase 1	Homo sapiens	66-69
30361436-5	2018	Studies with heterologously expressed human GLUT1, -3, or -4 reveal that quercetin-GLUT1 and -GLUT4 interactions are stronger than quercetin-GLUT3 interactions, that epicatechin gallate (ECG) is more selective for GLUT1, and that epigallocatechin gallate (EGCG) is less GLUT isoform-selective.	Quercetin	73-82	solute carrier family 2 member 1	Homo sapiens	44-49
30361436-5	2018	Studies with heterologously expressed human GLUT1, -3, or -4 reveal that quercetin-GLUT1 and -GLUT4 interactions are stronger than quercetin-GLUT3 interactions, that epicatechin gallate (ECG) is more selective for GLUT1, and that epigallocatechin gallate (EGCG) is less GLUT isoform-selective.	Quercetin	73-82	solute carrier family 2 member 1	Homo sapiens	83-88
30361436-5	2018	Studies with heterologously expressed human GLUT1, -3, or -4 reveal that quercetin-GLUT1 and -GLUT4 interactions are stronger than quercetin-GLUT3 interactions, that epicatechin gallate (ECG) is more selective for GLUT1, and that epigallocatechin gallate (EGCG) is less GLUT isoform-selective.	Quercetin	73-82	solute carrier family 2 member 4	Homo sapiens	94-99
30361436-5	2018	Studies with heterologously expressed human GLUT1, -3, or -4 reveal that quercetin-GLUT1 and -GLUT4 interactions are stronger than quercetin-GLUT3 interactions, that epicatechin gallate (ECG) is more selective for GLUT1, and that epigallocatechin gallate (EGCG) is less GLUT isoform-selective.	Quercetin	73-82	solute carrier family 2 member 1	Homo sapiens	83-88
30361436-5	2018	Studies with heterologously expressed human GLUT1, -3, or -4 reveal that quercetin-GLUT1 and -GLUT4 interactions are stronger than quercetin-GLUT3 interactions, that epicatechin gallate (ECG) is more selective for GLUT1, and that epigallocatechin gallate (EGCG) is less GLUT isoform-selective.	Quercetin	73-82	solute carrier family 2 member 1	Homo sapiens	44-48
30361436-5	2018	Studies with heterologously expressed human GLUT1, -3, or -4 reveal that quercetin-GLUT1 and -GLUT4 interactions are stronger than quercetin-GLUT3 interactions, that epicatechin gallate (ECG) is more selective for GLUT1, and that epigallocatechin gallate (EGCG) is less GLUT isoform-selective.	Quercetin	131-140	solute carrier family 2 member 3	Homo sapiens	141-146
30662673-0	2018	Quercetin rescued TNF-alpha-induced impairments in bone marrow-derived mesenchymal stem cell osteogenesis and improved osteoporosis in rats.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	18-27
30662673-8	2018	In vitro, TNF-alpha led to the activation of nuclear factor-kappa B (NF-kappaB) and the degradation of beta-catenin, which were significantly inhibited by quercetin.	Quercetin	155-164	tumor necrosis factor	Rattus norvegicus	10-19
30662673-8	2018	In vitro, TNF-alpha led to the activation of nuclear factor-kappa B (NF-kappaB) and the degradation of beta-catenin, which were significantly inhibited by quercetin.	Quercetin	155-164	catenin beta 1	Rattus norvegicus	103-115
30662673-10	2018	In conclusion, quercetin improved in vitro models of osteoporosis and protected against TNF-alpha-induced impairments in BMSC osteogenesis.	Quercetin	15-24	tumor necrosis factor	Rattus norvegicus	88-97
30662665-0	2018	Sensitization of keloid fibroblasts by quercetin through the PI3K/Akt pathway is dependent on regulation of HIF-1alpha.	Quercetin	39-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-118
30662665-8	2018	Further, we showed that hypoxia-inducible factor 1 (HIF-1), a prognostic marker used in clinical practice after radiation therapy, was associated with stronger radioresistance in keloid fibroblasts, which was downregulated after quercetin treatment.	Quercetin	229-238	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-50
30662665-8	2018	Further, we showed that hypoxia-inducible factor 1 (HIF-1), a prognostic marker used in clinical practice after radiation therapy, was associated with stronger radioresistance in keloid fibroblasts, which was downregulated after quercetin treatment.	Quercetin	229-238	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-57
30662665-9	2018	The inhibition of HIF-1 expression by quercetin was found to be dependent on the phosphatidylinositol-3-kinase (PI3K)/Akt pathway.	Quercetin	38-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-23
30662665-9	2018	The inhibition of HIF-1 expression by quercetin was found to be dependent on the phosphatidylinositol-3-kinase (PI3K)/Akt pathway.	Quercetin	38-47	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	81-110
30662665-9	2018	The inhibition of HIF-1 expression by quercetin was found to be dependent on the phosphatidylinositol-3-kinase (PI3K)/Akt pathway.	Quercetin	38-47	AKT serine/threonine kinase 1	Homo sapiens	118-121
30662665-10	2018	Quercetin has been reported to reduce the phosphorylation of Akt.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	61-64
30662665-11	2018	Taken together, we revealed one mechanism underlying the suppression of radioresistance by quercetin, which involved the regulation of HIF-1alpha by the PI3K/Akt pathway.	Quercetin	91-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	135-145
30662665-11	2018	Taken together, we revealed one mechanism underlying the suppression of radioresistance by quercetin, which involved the regulation of HIF-1alpha by the PI3K/Akt pathway.	Quercetin	91-100	AKT serine/threonine kinase 1	Homo sapiens	158-161
30584279-5	2018	The results also showed that mRNA and protein expression of epithelial-mesenchymal transition (EMT)-related markers such as alpha-smooth muscle actin and N-cadherin was downregulated by quercetin in TGF-beta1-treated RPE cells; conversely, quercetin upregulated the expression of E-cadherin and tight junction protein 1 (ZO-1).	Quercetin	240-249	transforming growth factor beta 1	Homo sapiens	199-208
30618732-9	2018	Furthermore, quercetin rescued the mitochondrial apoptotic pathway and neuronal degeneration by regulating Bax/Bcl2, and decreasing activated cytochrome c, caspase-3 activity and cleaving PARP-1 in the cortical and hippocampal regions of the mouse brain.	Quercetin	13-22	BCL2-associated X protein	Mus musculus	107-110
30618732-9	2018	Furthermore, quercetin rescued the mitochondrial apoptotic pathway and neuronal degeneration by regulating Bax/Bcl2, and decreasing activated cytochrome c, caspase-3 activity and cleaving PARP-1 in the cortical and hippocampal regions of the mouse brain.	Quercetin	13-22	B cell leukemia/lymphoma 2	Mus musculus	111-115
30618732-9	2018	Furthermore, quercetin rescued the mitochondrial apoptotic pathway and neuronal degeneration by regulating Bax/Bcl2, and decreasing activated cytochrome c, caspase-3 activity and cleaving PARP-1 in the cortical and hippocampal regions of the mouse brain.	Quercetin	13-22	caspase 3	Mus musculus	156-165
30618732-9	2018	Furthermore, quercetin rescued the mitochondrial apoptotic pathway and neuronal degeneration by regulating Bax/Bcl2, and decreasing activated cytochrome c, caspase-3 activity and cleaving PARP-1 in the cortical and hippocampal regions of the mouse brain.	Quercetin	13-22	poly (ADP-ribose) polymerase family, member 1	Mus musculus	188-194
30584279-1	2018	Purpose: The purpose of this study was to evaluate the effect and mechanism of quercetin on TGF-beta1-induced retinal pigment epithelial (RPE) cell proliferation, migration, and extracellular matrix secretion.	Quercetin	79-88	transforming growth factor beta 1	Homo sapiens	92-101
30584279-4	2018	Results: Quercetin suppressed TGF-beta1-induced cell proliferation, migration, and collagen I secretion.	Quercetin	9-18	transforming growth factor beta 1	Homo sapiens	30-39
30584279-5	2018	The results also showed that mRNA and protein expression of epithelial-mesenchymal transition (EMT)-related markers such as alpha-smooth muscle actin and N-cadherin was downregulated by quercetin in TGF-beta1-treated RPE cells; conversely, quercetin upregulated the expression of E-cadherin and tight junction protein 1 (ZO-1).	Quercetin	186-195	cadherin 2	Homo sapiens	154-164
30584279-5	2018	The results also showed that mRNA and protein expression of epithelial-mesenchymal transition (EMT)-related markers such as alpha-smooth muscle actin and N-cadherin was downregulated by quercetin in TGF-beta1-treated RPE cells; conversely, quercetin upregulated the expression of E-cadherin and tight junction protein 1 (ZO-1).	Quercetin	186-195	transforming growth factor beta 1	Homo sapiens	199-208
30584279-5	2018	The results also showed that mRNA and protein expression of epithelial-mesenchymal transition (EMT)-related markers such as alpha-smooth muscle actin and N-cadherin was downregulated by quercetin in TGF-beta1-treated RPE cells; conversely, quercetin upregulated the expression of E-cadherin and tight junction protein 1 (ZO-1).	Quercetin	186-195	cadherin 1	Homo sapiens	280-290
30584279-7	2018	Quercetin may reverse the progression of EMT via the Smad2/3 pathway.	Quercetin	0-9	SMAD family member 2	Homo sapiens	53-60
30584279-5	2018	The results also showed that mRNA and protein expression of epithelial-mesenchymal transition (EMT)-related markers such as alpha-smooth muscle actin and N-cadherin was downregulated by quercetin in TGF-beta1-treated RPE cells; conversely, quercetin upregulated the expression of E-cadherin and tight junction protein 1 (ZO-1).	Quercetin	186-195	tight junction protein 1	Homo sapiens	295-319
29940125-0	2018	Quercetin ameliorates pulmonary fibrosis by inhibiting SphK1/S1P signaling.	Quercetin	0-9	sphingosine kinase 1	Homo sapiens	55-60
29940125-4	2018	The quercetin administration ameliorated bleomycin-induced pulmonary fibrosis, evidenced by the expression level changes of hydroxyproline, fibronectin, alpha-smooth muscle actin, Collagen I, and Collagen III.	Quercetin	4-13	fibronectin 1	Homo sapiens	140-151
29940125-7	2018	However, the increase of S1P, SphK1, and S1PL was attenuated by application of quercetin.	Quercetin	79-88	sphingosine kinase 1	Homo sapiens	30-35
29940125-7	2018	However, the increase of S1P, SphK1, and S1PL was attenuated by application of quercetin.	Quercetin	79-88	sphingosine-1-phosphate lyase 1	Homo sapiens	41-45
29940125-8	2018	In addition, the effect of quercetin on fibrosis was abolished by the ectopic expression of SphK1.	Quercetin	27-36	sphingosine kinase 1	Homo sapiens	92-97
29940125-10	2018	In summary, we demonstrated that quercetin ameliorated pulmonary fibrosis in vivo and in vitro by inhibiting SphK1/S1P signaling.	Quercetin	33-42	sphingosine kinase 1	Homo sapiens	109-114
30076503-6	2018	RESULTS: Quercetin significantly suppressed protein levels of ICAM-1 and VCAM-1 induced by LPS.	Quercetin	9-18	intercellular adhesion molecule 1	Rattus norvegicus	62-68
30637162-12	2018	Our results also demonstrated that quercetin regulated SREBP-1 and its transcriptional targets.	Quercetin	35-44	sterol regulatory element binding transcription factor 1	Homo sapiens	55-62
30637162-13	2018	Furthermore, immunofluorescence staining showed that quercetin treatment decreased the immunoreactivities of OGT and SREBP-1 in HeLa cells.	Quercetin	53-62	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	109-112
30637162-13	2018	Furthermore, immunofluorescence staining showed that quercetin treatment decreased the immunoreactivities of OGT and SREBP-1 in HeLa cells.	Quercetin	53-62	sterol regulatory element binding transcription factor 1	Homo sapiens	117-124
30076503-6	2018	RESULTS: Quercetin significantly suppressed protein levels of ICAM-1 and VCAM-1 induced by LPS.	Quercetin	9-18	vascular cell adhesion molecule 1	Rattus norvegicus	73-79
30076503-7	2018	Quercetin also inhibited TLR4 expression, NF-kappaB p65, ERK, JNK and STAT phosphorylation and decreased IkappaB-alpha degradation.	Quercetin	0-9	toll-like receptor 4	Rattus norvegicus	25-29
30076503-7	2018	Quercetin also inhibited TLR4 expression, NF-kappaB p65, ERK, JNK and STAT phosphorylation and decreased IkappaB-alpha degradation.	Quercetin	0-9	synaptotagmin 1	Rattus norvegicus	52-55
30076503-7	2018	Quercetin also inhibited TLR4 expression, NF-kappaB p65, ERK, JNK and STAT phosphorylation and decreased IkappaB-alpha degradation.	Quercetin	0-9	Eph receptor B1	Rattus norvegicus	57-60
30076503-7	2018	Quercetin also inhibited TLR4 expression, NF-kappaB p65, ERK, JNK and STAT phosphorylation and decreased IkappaB-alpha degradation.	Quercetin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	62-65
30076503-7	2018	Quercetin also inhibited TLR4 expression, NF-kappaB p65, ERK, JNK and STAT phosphorylation and decreased IkappaB-alpha degradation.	Quercetin	0-9	NFKB inhibitor alpha	Rattus norvegicus	105-118
30076503-9	2018	CONCLUSIONS: These results indicate that quercetin may have an anti-inflammatory effect by inhibiting expression of ICAM-1 and VCAM-1 in RIMVECs by suppressing TLR4, NF-kappaB, ERK, JNK and STAT but not the p38 signaling pathway.	Quercetin	41-50	intercellular adhesion molecule 1	Rattus norvegicus	116-122
30076503-9	2018	CONCLUSIONS: These results indicate that quercetin may have an anti-inflammatory effect by inhibiting expression of ICAM-1 and VCAM-1 in RIMVECs by suppressing TLR4, NF-kappaB, ERK, JNK and STAT but not the p38 signaling pathway.	Quercetin	41-50	vascular cell adhesion molecule 1	Rattus norvegicus	127-133
30076503-9	2018	CONCLUSIONS: These results indicate that quercetin may have an anti-inflammatory effect by inhibiting expression of ICAM-1 and VCAM-1 in RIMVECs by suppressing TLR4, NF-kappaB, ERK, JNK and STAT but not the p38 signaling pathway.	Quercetin	41-50	toll-like receptor 4	Rattus norvegicus	160-164
30076503-9	2018	CONCLUSIONS: These results indicate that quercetin may have an anti-inflammatory effect by inhibiting expression of ICAM-1 and VCAM-1 in RIMVECs by suppressing TLR4, NF-kappaB, ERK, JNK and STAT but not the p38 signaling pathway.	Quercetin	41-50	Eph receptor B1	Rattus norvegicus	177-180
30076503-9	2018	CONCLUSIONS: These results indicate that quercetin may have an anti-inflammatory effect by inhibiting expression of ICAM-1 and VCAM-1 in RIMVECs by suppressing TLR4, NF-kappaB, ERK, JNK and STAT but not the p38 signaling pathway.	Quercetin	41-50	mitogen-activated protein kinase 8	Rattus norvegicus	182-185
30076503-9	2018	CONCLUSIONS: These results indicate that quercetin may have an anti-inflammatory effect by inhibiting expression of ICAM-1 and VCAM-1 in RIMVECs by suppressing TLR4, NF-kappaB, ERK, JNK and STAT but not the p38 signaling pathway.	Quercetin	41-50	mitogen activated protein kinase 14	Rattus norvegicus	207-210
30680297-11	2018	Conclusion: Our results indicated that the levels of IL-17, IL-33, and IL-6 in supernatants from patients" cultured T cells were increased after stimulation with HMGB-1 following employing quercetin.	Quercetin	189-198	interleukin 6	Homo sapiens	71-75
30266680-6	2018	A quercetin-stimulated increase in cellular NAD+/NADH was evident within 2 h and a two-fold increase in PGC-1alpha mRNA within 6 h, in both normal and high glucose conditions.	Quercetin	2-11	PPARG coactivator 1 alpha	Homo sapiens	104-114
30266680-7	2018	A similar pattern was also found for the mRNA expression of the repulsive guidance molecule b (RGMB) and its long non-coding RNA (lncRNA) RGMB-AS1 with quercetin, indicating a potential change of the glycolytic phenotype and suppression of aberrant cellular growth which is characteristic of the HepG2 cells.	Quercetin	152-161	repulsive guidance molecule BMP co-receptor b	Homo sapiens	64-93
30266680-7	2018	A similar pattern was also found for the mRNA expression of the repulsive guidance molecule b (RGMB) and its long non-coding RNA (lncRNA) RGMB-AS1 with quercetin, indicating a potential change of the glycolytic phenotype and suppression of aberrant cellular growth which is characteristic of the HepG2 cells.	Quercetin	152-161	repulsive guidance molecule BMP co-receptor b	Homo sapiens	95-99
30266680-7	2018	A similar pattern was also found for the mRNA expression of the repulsive guidance molecule b (RGMB) and its long non-coding RNA (lncRNA) RGMB-AS1 with quercetin, indicating a potential change of the glycolytic phenotype and suppression of aberrant cellular growth which is characteristic of the HepG2 cells.	Quercetin	152-161	RGMB antisense RNA 1	Homo sapiens	138-146
30266680-8	2018	Direct effects of quercetin on PGC-1alpha activity were minimal, as quercetin only weakly enhanced PGC-1alpha binding to PPARalpha in vitro at higher concentrations.	Quercetin	68-77	PPARG coactivator 1 alpha	Homo sapiens	99-109
30266680-8	2018	Direct effects of quercetin on PGC-1alpha activity were minimal, as quercetin only weakly enhanced PGC-1alpha binding to PPARalpha in vitro at higher concentrations.	Quercetin	68-77	peroxisome proliferator activated receptor alpha	Homo sapiens	121-130
30266680-9	2018	Our results suggest that quercetin may protect mitochondrial function from high glucose-induced stress by increasing cellular NAD+/NADH and activation of PGC-1alpha-mediated pathways.	Quercetin	25-34	PPARG coactivator 1 alpha	Homo sapiens	154-164
30187968-8	2018	We partition this multicomponent review into how quercetin effectively regulates the Wnt/beta-catenin pathway, Janus kinase-signal transducer and activator of transcription pathway, and vascular endothelial growth factor/vascular endothelial growth factor receptor signaling cascade in different types of cancers.	Quercetin	49-58	catenin beta 1	Homo sapiens	89-101
30187968-9	2018	We also provide an overview of the regulation of NOTCH and SHH pathways by quercetin.	Quercetin	75-84	sonic hedgehog signaling molecule	Homo sapiens	59-62
30187968-11	2018	We have scattered information related to NOTCH and SHH pathways, and future studies must converge on the investigation of these pathways to see how quercetin modulates the signaling machinery of these pathways.	Quercetin	148-157	sonic hedgehog signaling molecule	Homo sapiens	51-54
30680297-0	2018	Quercetin Decreases Th17 Production by Down-Regulation of MAPK- TLR4 Signaling Pathway on T Cells in Dental Pulpitis.	Quercetin	0-9	toll like receptor 4	Homo sapiens	64-68
30680297-1	2018	Statement of the Problem: Quercetin is a pharmacological flavonoid that can inhibit high mobility group box1 (HMGB1) protein, a non-histone nuclear protein that is implicated in inflammation.	Quercetin	26-35	high mobility group box 1	Homo sapiens	84-108
30680297-1	2018	Statement of the Problem: Quercetin is a pharmacological flavonoid that can inhibit high mobility group box1 (HMGB1) protein, a non-histone nuclear protein that is implicated in inflammation.	Quercetin	26-35	high mobility group box 1	Homo sapiens	110-115
30680297-5	2018	Purpose: The current study aimed to compare blocking of HMGB1 function and stimulation of HMGB1 function with quercetin and investigate the effects of the blockage on T helper 17 (Th17) cells and mitogen-activated protein kinase Toll-like receptor 4 (MAPK-TLR4) signaling pathway.	Quercetin	110-119	high mobility group box 1	Homo sapiens	90-95
30680297-9	2018	Results: The level of these cytokines decreased; moreover, western blot data showed that quercetin could decrease MAPK signaling pathway by means of inhibition of HMGB1 on T cells.	Quercetin	89-98	high mobility group box 1	Homo sapiens	163-168
30680297-11	2018	Conclusion: Our results indicated that the levels of IL-17, IL-33, and IL-6 in supernatants from patients" cultured T cells were increased after stimulation with HMGB-1 following employing quercetin.	Quercetin	189-198	interleukin 17A	Homo sapiens	53-58
30680297-11	2018	Conclusion: Our results indicated that the levels of IL-17, IL-33, and IL-6 in supernatants from patients" cultured T cells were increased after stimulation with HMGB-1 following employing quercetin.	Quercetin	189-198	interleukin 33	Homo sapiens	60-65
30680297-11	2018	Conclusion: Our results indicated that the levels of IL-17, IL-33, and IL-6 in supernatants from patients" cultured T cells were increased after stimulation with HMGB-1 following employing quercetin.	Quercetin	189-198	high mobility group box 1	Homo sapiens	162-168
30680297-13	2018	Quercetin could decrease pro-inflammatory cytokines and IL-17 production.	Quercetin	0-9	interleukin 17A	Homo sapiens	56-61
30069621-4	2018	The malondialdehyde and catalase (CAT) levels and glutathione-S-transferase (GST) activity were increased significantly in Cd-treated group, but were reversed by quercetin (all doses).	Quercetin	162-171	catalase	Mus musculus	24-32
30069621-4	2018	The malondialdehyde and catalase (CAT) levels and glutathione-S-transferase (GST) activity were increased significantly in Cd-treated group, but were reversed by quercetin (all doses).	Quercetin	162-171	catalase	Mus musculus	34-37
30069621-4	2018	The malondialdehyde and catalase (CAT) levels and glutathione-S-transferase (GST) activity were increased significantly in Cd-treated group, but were reversed by quercetin (all doses).	Quercetin	162-171	hematopoietic prostaglandin D synthase	Mus musculus	50-75
30069621-4	2018	The malondialdehyde and catalase (CAT) levels and glutathione-S-transferase (GST) activity were increased significantly in Cd-treated group, but were reversed by quercetin (all doses).	Quercetin	162-171	hematopoietic prostaglandin D synthase	Mus musculus	77-80
30069621-5	2018	The gene expression for CAT and GST in brain tissue of Cd treated animals also increased many folds as compared to the control, and this effect was decreased on co-treatment with quercetin (all doses), thus matching with the respective enzyme activities.	Quercetin	179-188	catalase	Mus musculus	24-27
30069621-5	2018	The gene expression for CAT and GST in brain tissue of Cd treated animals also increased many folds as compared to the control, and this effect was decreased on co-treatment with quercetin (all doses), thus matching with the respective enzyme activities.	Quercetin	179-188	hematopoietic prostaglandin D synthase	Mus musculus	32-35
30069621-6	2018	Quercetin (25 mg/kg) when co-treated with Cd caused a decrease in GST activity compared to control, which points towards a complex interplay with oxidative free radicals and promoters and transcription factors.	Quercetin	0-9	hematopoietic prostaglandin D synthase	Mus musculus	66-69
30501693-0	2018	[Effect of Quercetin on the Cell Cycle and Adhesion Molecules of NOD/SCID Mice with Acute B Lymphocytic Leukemia].	Quercetin	11-20	atrophin 1	Homo sapiens	65-68
30328681-0	2018	Effects of Quercetin Intervention on Cognition Function in APP/PS1 Mice was Affected by Vitamin D Status.	Quercetin	11-20	presenilin 1	Mus musculus	63-66
30328681-1	2018	SCOPE: To explore how quercetin will affect memory impairments in APP/PS1 mice under different vitamin D status.	Quercetin	22-31	presenilin 1	Mus musculus	70-73
30266078-12	2018	Therefore, FOS, AHR, JUN, CYP1A1, EGR1, FOSL1, and WNT7B might be targets of quercetin in gastric cancer.	Quercetin	77-86	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	11-14
30266078-12	2018	Therefore, FOS, AHR, JUN, CYP1A1, EGR1, FOSL1, and WNT7B might be targets of quercetin in gastric cancer.	Quercetin	77-86	aryl hydrocarbon receptor	Homo sapiens	16-19
30266078-12	2018	Therefore, FOS, AHR, JUN, CYP1A1, EGR1, FOSL1, and WNT7B might be targets of quercetin in gastric cancer.	Quercetin	77-86	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-32
30266078-12	2018	Therefore, FOS, AHR, JUN, CYP1A1, EGR1, FOSL1, and WNT7B might be targets of quercetin in gastric cancer.	Quercetin	77-86	early growth response 1	Homo sapiens	34-38
30266078-12	2018	Therefore, FOS, AHR, JUN, CYP1A1, EGR1, FOSL1, and WNT7B might be targets of quercetin in gastric cancer.	Quercetin	77-86	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	40-45
30266078-12	2018	Therefore, FOS, AHR, JUN, CYP1A1, EGR1, FOSL1, and WNT7B might be targets of quercetin in gastric cancer.	Quercetin	77-86	Wnt family member 7B	Homo sapiens	51-56
29952685-0	2018	Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal.	Quercetin	0-9	solute carrier family 13 member 2	Rattus norvegicus	49-54
30501693-1	2018	OBJECTIVE: To investigate the effect of Quercetin on cell cycle and adhesive molecules of NOD.SCID mice with acule B lymphocytic leuaemia(B-ALL).	Quercetin	40-49	atrophin 1	Homo sapiens	90-93
30584425-8	2018	The treatment with Quercetin showed nonsignificant differences as compared to treatment with DFO that chelated the serum and tissue iron and improved the oxidative stress and reduced tissue IL6 and increased IL10 and decreased caspase 3 and iNOs expressing cells in small intestinal tissues.	Quercetin	19-28	interleukin 6	Rattus norvegicus	190-193
30360615-9	2018	The proinflammatory cytokines TNF-alpha and IL-6 were alleviated by quercetin, genistein, and naringenin.	Quercetin	68-77	tumor necrosis factor	Rattus norvegicus	30-39
30360615-9	2018	The proinflammatory cytokines TNF-alpha and IL-6 were alleviated by quercetin, genistein, and naringenin.	Quercetin	68-77	interleukin 6	Rattus norvegicus	44-48
30477461-4	2018	The binding interaction of flavonoids (theaflavin, quercetin, rutin, epicatechin 3 gallate and tamarixetin) with GSK 3beta was determined by molecular docking.	Quercetin	51-60	glycogen synthase kinase 3 beta	Homo sapiens	113-122
30469393-0	2018	Quercetin Enhances the Thioredoxin Production of Nasal Epithelial Cells In Vitro and In Vivo.	Quercetin	0-9	thioredoxin 1	Mus musculus	23-34
30584425-8	2018	The treatment with Quercetin showed nonsignificant differences as compared to treatment with DFO that chelated the serum and tissue iron and improved the oxidative stress and reduced tissue IL6 and increased IL10 and decreased caspase 3 and iNOs expressing cells in small intestinal tissues.	Quercetin	19-28	interleukin 10	Rattus norvegicus	208-212
30469393-3	2018	The present study was designed to examine whether quercetin could favorably modify AR symptoms via the TRX production of nasal epithelial cells in vitro and in vivo.	Quercetin	50-59	thioredoxin 1	Mus musculus	103-106
30469393-10	2018	Results: Treatment with 1.0 nM quercetin increased H2O2-induced TRX levels.	Quercetin	31-40	thioredoxin 1	Mus musculus	64-67
30584425-8	2018	The treatment with Quercetin showed nonsignificant differences as compared to treatment with DFO that chelated the serum and tissue iron and improved the oxidative stress and reduced tissue IL6 and increased IL10 and decreased caspase 3 and iNOs expressing cells in small intestinal tissues.	Quercetin	19-28	caspase 3	Rattus norvegicus	227-236
30469393-12	2018	The same dose of quercetin significantly increased TRX levels in nasal lavage fluids.	Quercetin	17-26	thioredoxin 1	Mus musculus	51-54
30584425-8	2018	The treatment with Quercetin showed nonsignificant differences as compared to treatment with DFO that chelated the serum and tissue iron and improved the oxidative stress and reduced tissue IL6 and increased IL10 and decreased caspase 3 and iNOs expressing cells in small intestinal tissues.	Quercetin	19-28	nitric oxide synthase 2	Rattus norvegicus	241-245
30469393-13	2018	Conclusions: Quercetin"s ability to increase TRX production may account, at least in part, for its clinical efficacy toward AR.	Quercetin	13-22	thioredoxin 1	Mus musculus	45-48
30152185-5	2018	Results from western blotting showed that quercetin decreased anti-apoptotic protein of Mcl-1, Bcl-2, and Bcl-x but increased pro-apoptotic protein of Bad, Bax, and Bid.	Quercetin	42-51	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	88-93
30301531-9	2018	We evaluated IL-6 and IL-10 reporter expression in LPS-induced RAW 264.7 cells with well-known anti-inflammatory compounds such as quercetin, xanthones, beta-D-glucan and dexamethasone.	Quercetin	131-140	interleukin 10	Mus musculus	22-27
30301531-12	2018	The expression of IL-10 reporter was inhibited by quercetin, xanthones and dexamethasone in LPS-induced RAW 264.7 cells.	Quercetin	50-59	interleukin 10	Mus musculus	18-23
30510558-4	2018	Following transient and stable expression in Nicotiana and Arabidopsis, respectively, the GSTs were recovered using Strep-Tactin affinity chromatography and the bound ligands desorbed and characterized by LC-MS. AtGSTF2 predominantly bound phenolic derivatives including S-glutathionylated lignanamides and methylated variants of the flavonols kaempferol and quercetin.	Quercetin	359-368	glutathione S-transferase PHI 2	Arabidopsis thaliana	212-219
29345961-3	2018	The aim of this study was to investigate the effects of two flavonoids, quercetin and kaempferol, and exogenous glutathione (GSH) on the expressions of phospho- and total-AKT levels in 3T3-L1 preadipocytes.	Quercetin	72-81	thymoma viral proto-oncogene 1	Mus musculus	171-174
29345961-7	2018	However, significant (p &lt;.05) decreases in phospho-AKT levels in cells treated with quercetin, kaempferol, and GSH at certain doses were observed compared to their respective controls.	Quercetin	87-96	thymoma viral proto-oncogene 1	Mus musculus	54-57
29345961-10	2018	Findings suggest that exposure of 3T3-L1 preadipocytes to quercetin, kaempferol, and GSH may block the activation of AKT, suggesting the role such compounds play in cell differentiation in 3T3-L1 cells.	Quercetin	58-67	thymoma viral proto-oncogene 1	Mus musculus	117-120
30130672-13	2018	Furthermore, 20 muM of quercetin increases both mRNA and protein levels of TGF-beta3 under basal and wound conditions without affecting TGF-beta1 production.	Quercetin	23-32	transforming growth factor beta 3	Homo sapiens	75-84
30142541-0	2018	Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway.	Quercetin	49-58	AKT serine/threonine kinase 1	Homo sapiens	124-127
30142541-0	2018	Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway.	Quercetin	49-58	mitogen-activated protein kinase 1	Homo sapiens	137-140
30142541-5	2018	KEY FINDINGS: Quercetin treatment for 24-72 h inhibited PC3 and CD44+/CD133+ stem cell proliferation in a time- and dose-dependent manner.	Quercetin	14-23	proprotein convertase subtilisin/kexin type 1	Homo sapiens	56-59
30152185-5	2018	Results from western blotting showed that quercetin decreased anti-apoptotic protein of Mcl-1, Bcl-2, and Bcl-x but increased pro-apoptotic protein of Bad, Bax, and Bid.	Quercetin	42-51	BCL2 apoptosis regulator	Homo sapiens	95-100
30152185-5	2018	Results from western blotting showed that quercetin decreased anti-apoptotic protein of Mcl-1, Bcl-2, and Bcl-x but increased pro-apoptotic protein of Bad, Bax, and Bid.	Quercetin	42-51	BCL2 like 1	Homo sapiens	106-111
30152185-5	2018	Results from western blotting showed that quercetin decreased anti-apoptotic protein of Mcl-1, Bcl-2, and Bcl-x but increased pro-apoptotic protein of Bad, Bax, and Bid.	Quercetin	42-51	BCL2 associated X, apoptosis regulator	Homo sapiens	156-159
30152185-5	2018	Results from western blotting showed that quercetin decreased anti-apoptotic protein of Mcl-1, Bcl-2, and Bcl-x but increased pro-apoptotic protein of Bad, Bax, and Bid.	Quercetin	42-51	BH3 interacting domain death agonist	Homo sapiens	165-168
31949595-0	2018	The mechanism of quercetin in regulating osteoclast activation and the PAR2/TRPV1 signaling pathway in the treatment of bone cancer pain.	Quercetin	17-26	F2R like trypsin receptor 1	Rattus norvegicus	71-75
31949595-6	2018	RESULTS: Quercetin significantly reduces serum CTX, TRAP and osteocalcin expressions in a rat model of bone cancer pain and also significantly reduces the proportion of TRAP-positive cells.	Quercetin	9-18	acid phosphatase 5, tartrate resistant	Rattus norvegicus	52-56
31949595-6	2018	RESULTS: Quercetin significantly reduces serum CTX, TRAP and osteocalcin expressions in a rat model of bone cancer pain and also significantly reduces the proportion of TRAP-positive cells.	Quercetin	9-18	bone gamma-carboxyglutamate protein	Rattus norvegicus	61-72
31949595-6	2018	RESULTS: Quercetin significantly reduces serum CTX, TRAP and osteocalcin expressions in a rat model of bone cancer pain and also significantly reduces the proportion of TRAP-positive cells.	Quercetin	9-18	acid phosphatase 5, tartrate resistant	Rattus norvegicus	169-173
31949595-9	2018	CONCLUSION: Quercetin can inhibit osteoclast activation and reduce bone destruction in the bone cancer pain model by regulating the RANKL/RANK/OPG signaling pathway and the inflammatory response.	Quercetin	12-21	TNF superfamily member 11	Rattus norvegicus	132-137
31949595-9	2018	CONCLUSION: Quercetin can inhibit osteoclast activation and reduce bone destruction in the bone cancer pain model by regulating the RANKL/RANK/OPG signaling pathway and the inflammatory response.	Quercetin	12-21	TNF receptor superfamily member 11B	Rattus norvegicus	143-146
30303965-3	2018	Here, an interdisciplinary approach using atomic force microscopy (AFM) and cellular and biological molecular methods were used to investigate oxidative damage in P19 neurons and to reveal the underlying mechanism of protective action of quercetin.	Quercetin	238-247	interleukin 23 subunit alpha	Homo sapiens	163-166
30062709-5	2018	Following supplementation, quercetin significantly decreased resistin concentration (2.07 +- 0.23 vs. 2.88 +- 0.40 ng/ml, p &lt; 0.001) and mRNA level (0.64 +- 0.58 vs. 1 +- 0.56 fold change, p = 0.008), compared with placebo group.	Quercetin	27-36	resistin	Homo sapiens	61-69
30062709-7	2018	Fasting blood glucose (p &lt; 0.001), insulin (p = 0.02), and homeostatic model assessment of insulin resistance (p = 0.009) decreased within the quercetin group; however, no significant differences were observed compared with the placebo group (p = 0.074, p = 0.226, p = 0.22, respectively).	Quercetin	146-155	insulin	Homo sapiens	38-45
30062709-7	2018	Fasting blood glucose (p &lt; 0.001), insulin (p = 0.02), and homeostatic model assessment of insulin resistance (p = 0.009) decreased within the quercetin group; however, no significant differences were observed compared with the placebo group (p = 0.074, p = 0.226, p = 0.22, respectively).	Quercetin	146-155	insulin	Homo sapiens	94-101
30062709-8	2018	Quercetin supplementation decreased resistin plasma levels and gene expression, and testosterone and LH concentration in overweight or obese women with PCOS.	Quercetin	0-9	resistin	Homo sapiens	36-44
30510622-0	2018	Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin.	Quercetin	78-87	transcription factor EB	Homo sapiens	10-14
30510622-0	2018	Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin.	Quercetin	78-87	CREB regulated transcription coactivator 1	Mus musculus	61-67
30510622-3	2018	In the current study, we show that a naturally occurring polyphenolic compound, quercetin, promoted TFEB nuclear translocation and enhanced its transcriptional activity in cultured RPE cells.	Quercetin	80-89	transcription factor EB	Homo sapiens	100-104
30510622-5	2018	Quercetin is a direct inhibitor of mTOR but did not influence the activity of Akt at the tested concentration range.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	35-39
30510622-6	2018	Our data suggest that the dietary compound quercetin can have beneficial roles in neuronal tissues by improving the functions of the TFEB-lysosome axis and enhancing the capacities of cellular degradation and self-renewal.	Quercetin	43-52	transcription factor EB	Homo sapiens	133-137
30062553-0	2018	Enhancement of glyoxalase 1, a polyfunctional defense enzyme, by quercetin in the brain in streptozotocin-induced diabetic rats.	Quercetin	65-74	glyoxalase 1	Rattus norvegicus	15-27
30062553-8	2018	Quercetin also significantly decreased the levels of inflammatory markers (cyclooxygenase-2, interleukin-1beta, and tumor necrosis factor alpha) in diabetic brains.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	75-91
30062553-8	2018	Quercetin also significantly decreased the levels of inflammatory markers (cyclooxygenase-2, interleukin-1beta, and tumor necrosis factor alpha) in diabetic brains.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	93-110
30062553-8	2018	Quercetin also significantly decreased the levels of inflammatory markers (cyclooxygenase-2, interleukin-1beta, and tumor necrosis factor alpha) in diabetic brains.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	116-143
30062553-9	2018	Most importantly, Glo-1 activity and protein expression were increased in quercetin-treated diabetic rat brains compared with untreated diabetic brains.	Quercetin	74-83	glyoxalase 1	Rattus norvegicus	18-23
30062553-10	2018	These results indicate that quercetin exerts beneficial effects by decreasing protein glycation, oxidative stress, and inflammation through the upregulation of Glo-1, which may ameliorate diabetic encephalopathy.	Quercetin	28-37	glyoxalase 1	Rattus norvegicus	160-165
30303965-4	2018	Biological methods demonstrated the oxidative damage of P19 neurons and showed that quercetin improved neuronal survival by preventing H2O2-induced p53 and Bcl-2 down-regulation and modulated Akt and ERK1/2 signalling pathways.	Quercetin	84-93	interleukin 23 subunit alpha	Homo sapiens	56-59
30303965-4	2018	Biological methods demonstrated the oxidative damage of P19 neurons and showed that quercetin improved neuronal survival by preventing H2O2-induced p53 and Bcl-2 down-regulation and modulated Akt and ERK1/2 signalling pathways.	Quercetin	84-93	tumor protein p53	Homo sapiens	148-151
30303965-4	2018	Biological methods demonstrated the oxidative damage of P19 neurons and showed that quercetin improved neuronal survival by preventing H2O2-induced p53 and Bcl-2 down-regulation and modulated Akt and ERK1/2 signalling pathways.	Quercetin	84-93	BCL2 apoptosis regulator	Homo sapiens	156-161
30303965-4	2018	Biological methods demonstrated the oxidative damage of P19 neurons and showed that quercetin improved neuronal survival by preventing H2O2-induced p53 and Bcl-2 down-regulation and modulated Akt and ERK1/2 signalling pathways.	Quercetin	84-93	AKT serine/threonine kinase 1	Homo sapiens	192-195
30303965-4	2018	Biological methods demonstrated the oxidative damage of P19 neurons and showed that quercetin improved neuronal survival by preventing H2O2-induced p53 and Bcl-2 down-regulation and modulated Akt and ERK1/2 signalling pathways.	Quercetin	84-93	mitogen-activated protein kinase 3	Homo sapiens	200-206
30369602-8	2018	Quercetin inhibited GFAP in the satellite glial cells of the ipsilateral L5 DRG on day 7 compared to the control group.	Quercetin	0-9	glial fibrillary acidic protein	Rattus norvegicus	20-24
30284027-7	2018	Response is linear in the 10-1000 ng mL-1 quercetin concentration range.	Quercetin	42-51	L1 cell adhesion molecule	Mus musculus	37-41
29397540-5	2018	Moreover, in goat zygotes, quercetin decreased peroxidation products including ROS, MDA, and carbonyl through preserving or maintaining mitochondrial function, gene expression, and anti-oxidative products such as glutathione peroxidase, superoxide dismutase, and catalase, which ameliorated subsequent embryo development and embryo quality (p &lt; 0.05).	Quercetin	27-36	catalase	Capra hircus	263-271
30218264-6	2018	Adsorbing SEDDS onto porous excipients led to satisfactory stability, with the exception of Zeopharm  600 due to its high alkalinity, and Neusilin  US2/UFL2, which caused quercetin to crystallize out of the liquid concentrate.	Quercetin	171-180	usherin	Homo sapiens	148-151
30207377-0	2018	Probing the interaction of a quercetin bioconjugate with Bcl-2 in living human cancer cells with in-cell NMR spectroscopy.	Quercetin	29-38	BCL2 apoptosis regulator	Homo sapiens	57-62
30171828-0	2018	Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells.	Quercetin	87-96	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
30171828-3	2018	Quercetin increased the levels of pro-inflammatory NFkB p65 in the nucleus correspondingly reducing them in the cytosol.	Quercetin	0-9	RELA proto-oncogene, NF-kB subunit	Homo sapiens	56-59
30171828-8	2018	Quercetin increased the levels of Nrf2 in the cytosol reducing them in the nucleus.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
30171828-10	2018	All these data support a relevant differential role for NFkB and Nrf2 in anti-inflammatory and redox response when apoptosis was induced by esculetin or quercetin in human leukemia NB4 cells.	Quercetin	153-162	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
29030990-0	2018	Novel nanohydrogel of hyaluronic acid loaded with quercetin alone and in combination with temozolomide as new therapeutic tool, CD44 targeted based, of glioblastoma multiforme.	Quercetin	50-59	CD44 molecule (Indian blood group)	Homo sapiens	128-132
29616452-9	2018	Quercetin significantly alleviated joint inflammation by reducing the levels of circulating cytokines and MMPs.	Quercetin	0-9	matrix metallopeptidase 3	Mus musculus	106-110
29030990-5	2018	The nanohydrogel loaded with quercetin had the ability to recognize CD44 receptor, a brain cancer cell marker, through an energy and caveolae dependent mechanism of internalization.	Quercetin	29-38	CD44 molecule (Indian blood group)	Homo sapiens	68-72
29030990-6	2018	Moreover, nanohydrogel of quercetin was able to reduce significantly IL-8, IL-6, and VEGF production in pro-inflammatory conditions with interesting implications on the mechanism of glioblastoma cells drug resistance.	Quercetin	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
29030990-6	2018	Moreover, nanohydrogel of quercetin was able to reduce significantly IL-8, IL-6, and VEGF production in pro-inflammatory conditions with interesting implications on the mechanism of glioblastoma cells drug resistance.	Quercetin	26-35	interleukin 6	Homo sapiens	75-79
29030990-6	2018	Moreover, nanohydrogel of quercetin was able to reduce significantly IL-8, IL-6, and VEGF production in pro-inflammatory conditions with interesting implications on the mechanism of glioblastoma cells drug resistance.	Quercetin	26-35	vascular endothelial growth factor A	Homo sapiens	85-89
29030990-7	2018	In summary, novel CD44 targeted polymeric based nanocarriers appear to be proficient in mediating site-specific delivery of quercetin via CD44 receptor in glioblastoma cells.	Quercetin	124-133	CD44 molecule (Indian blood group)	Homo sapiens	18-22
29030990-7	2018	In summary, novel CD44 targeted polymeric based nanocarriers appear to be proficient in mediating site-specific delivery of quercetin via CD44 receptor in glioblastoma cells.	Quercetin	124-133	CD44 molecule (Indian blood group)	Homo sapiens	138-142
30115563-0	2018	Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition.	Quercetin	0-9	toll-like receptor 4	Rattus norvegicus	116-120
30115563-0	2018	Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition.	Quercetin	0-9	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	121-126
30115563-0	2018	Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition.	Quercetin	0-9	mitogen activated protein kinase 14	Rattus norvegicus	127-130
30115563-11	2018	CONCLUSIONS: Quercetin plays a protective role against intestinal barrier disruption and inflammation in ANP, probably partly by inhibiting TLR4/MyD88/p38 MAPK and ERS activation.	Quercetin	13-22	toll-like receptor 4	Rattus norvegicus	140-144
30115563-11	2018	CONCLUSIONS: Quercetin plays a protective role against intestinal barrier disruption and inflammation in ANP, probably partly by inhibiting TLR4/MyD88/p38 MAPK and ERS activation.	Quercetin	13-22	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	145-150
30115563-11	2018	CONCLUSIONS: Quercetin plays a protective role against intestinal barrier disruption and inflammation in ANP, probably partly by inhibiting TLR4/MyD88/p38 MAPK and ERS activation.	Quercetin	13-22	mitogen activated protein kinase 14	Rattus norvegicus	151-154
30267998-10	2018	The quercetin and B. dracunculifolia treatment decreased morbimortality in post-challenge treatment (Ex-1) and EHV-1 related lesions (Ex-2).	Quercetin	4-13	FERM domain containing 6	Homo sapiens	101-105
28990837-0	2018	Quercetin nanoparticles alter pharmacokinetics of bromocriptine, reflecting its enhanced inhibitory action on liver and intestinal CYP 3A enzymes in rats.	Quercetin	0-9	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	131-137
29908597-4	2018	Under optimized conditions, the calibration graph for quercetin was linear in the range of 20-4000 ng mL-1; the limit of detection and quantitation were 4.35 and 14.97 ng mL-1, respectively and the enrichment factor was 95.24.	Quercetin	54-63	L1 cell adhesion molecule	Mus musculus	102-106
29908597-4	2018	Under optimized conditions, the calibration graph for quercetin was linear in the range of 20-4000 ng mL-1; the limit of detection and quantitation were 4.35 and 14.97 ng mL-1, respectively and the enrichment factor was 95.24.	Quercetin	54-63	L1 cell adhesion molecule	Mus musculus	171-175
28990837-2	2018	Quercetin is a dietary flavonoid has extremely low water solubility and found to possess CYP3A inhibitory activity.	Quercetin	0-9	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	89-94
28990837-9	2018	The results indicate that quercetin significantly (p &lt; 0.05) inhibited the CYP3A activity in liver and intestinal microsomes.	Quercetin	26-35	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	78-83
28990837-14	2018	NQC pretreatment might be result in higher plasma levels of quercetin that could inhibit the CYP3A enzyme and enhanced the bioavailability of BRO.	Quercetin	60-69	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	93-98
29857000-6	2018	In the current study, we investigated the issue of whether or how Quercetin attenuates poly (dA:dT), a synthetic analog of microbial dsDNA, -induced IL-18 secretion in IFN-gamma-primed human keratinocytes.	Quercetin	66-75	interferon gamma	Homo sapiens	168-177
30166062-10	2018	Antioxidants, such as N-acetyl-l-cysteine and quercetin, markedly inhibited the nuclear-to-cytoplasmic translocation of HMGB1 and its release into the extracellular milieu.	Quercetin	46-55	high mobility group box 1	Homo sapiens	120-125
30200670-4	2018	Notably, 50 micromolar resveratrol and quercetin fully suppressed the low constitutive levels of type I interferon signaling and prevented its activation by the anti-EGFR cetuximab or gefitinib in cultured keratinocytes.	Quercetin	39-48	epidermal growth factor receptor	Homo sapiens	166-170
30200670-6	2018	Overall, these data suggest that topical application of resveratrol or quercetin could be potentially effective in preventing pathological conditions due to overactivation of type I IFN (interferon)-driven circuits in the skin, including the inflammatory manifestations of anti-EGFR drug-induced skin-targeted toxicity.	Quercetin	71-80	epidermal growth factor receptor	Homo sapiens	278-282
29857000-0	2018	Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes.	Quercetin	0-9	interleukin 18	Homo sapiens	56-61
29857000-0	2018	Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes.	Quercetin	0-9	absent in melanoma 2	Homo sapiens	104-108
29857000-0	2018	Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes.	Quercetin	0-9	caspase 1	Homo sapiens	117-126
29857000-0	2018	Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes.	Quercetin	0-9	Janus kinase 2	Homo sapiens	145-149
29857000-0	2018	Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes.	Quercetin	0-9	signal transducer and activator of transcription 1	Homo sapiens	150-155
30233175-4	2018	In parallel, quercetin delivery decreased the expression of Wnt16 and P-glycoprotein, thus remodeling the tumor microenvironment and reversed multidrug resistance to facilitate DOX activity.	Quercetin	13-22	Wnt family member 16	Homo sapiens	60-65
30233175-4	2018	In parallel, quercetin delivery decreased the expression of Wnt16 and P-glycoprotein, thus remodeling the tumor microenvironment and reversed multidrug resistance to facilitate DOX activity.	Quercetin	13-22	ATP binding cassette subfamily B member 1	Homo sapiens	70-84
29857000-0	2018	Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed human keratinocytes.	Quercetin	0-9	interferon gamma	Homo sapiens	167-176
29857000-7	2018	Treatment with 5 and 10 muM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-gamma priming and before poly (dA:dT)-induced AIM2 activation.	Quercetin	31-40	interleukin 18	Homo sapiens	89-94
29857000-7	2018	Treatment with 5 and 10 muM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-gamma priming and before poly (dA:dT)-induced AIM2 activation.	Quercetin	31-40	interferon gamma	Homo sapiens	101-110
29857000-7	2018	Treatment with 5 and 10 muM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-gamma priming and before poly (dA:dT)-induced AIM2 activation.	Quercetin	31-40	absent in melanoma 2	Homo sapiens	151-155
29857000-8	2018	In addition, treatment with Quercetin at 10 muM, significantly inhibited the phosphorylation of JAK2 and STAT1, and the nuclear translocation of phosphorylated STAT1 in poly (dA:dT)-treated and IFN-gamma-primed keratinocytes.	Quercetin	28-37	Janus kinase 2	Homo sapiens	96-100
29857000-8	2018	In addition, treatment with Quercetin at 10 muM, significantly inhibited the phosphorylation of JAK2 and STAT1, and the nuclear translocation of phosphorylated STAT1 in poly (dA:dT)-treated and IFN-gamma-primed keratinocytes.	Quercetin	28-37	signal transducer and activator of transcription 1	Homo sapiens	105-110
29857000-8	2018	In addition, treatment with Quercetin at 10 muM, significantly inhibited the phosphorylation of JAK2 and STAT1, and the nuclear translocation of phosphorylated STAT1 in poly (dA:dT)-treated and IFN-gamma-primed keratinocytes.	Quercetin	28-37	signal transducer and activator of transcription 1	Homo sapiens	160-165
29857000-8	2018	In addition, treatment with Quercetin at 10 muM, significantly inhibited the phosphorylation of JAK2 and STAT1, and the nuclear translocation of phosphorylated STAT1 in poly (dA:dT)-treated and IFN-gamma-primed keratinocytes.	Quercetin	28-37	interferon gamma	Homo sapiens	194-203
29857000-9	2018	These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes.	Quercetin	42-51	interleukin 18	Homo sapiens	99-104
29857000-9	2018	These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes.	Quercetin	42-51	absent in melanoma 2	Homo sapiens	147-151
29857000-9	2018	These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes.	Quercetin	42-51	caspase 1	Homo sapiens	160-169
29857000-9	2018	These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes.	Quercetin	42-51	Janus kinase 2	Homo sapiens	188-192
29857000-9	2018	These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes.	Quercetin	42-51	signal transducer and activator of transcription 1	Homo sapiens	193-198
29857000-9	2018	These results suggest that treatment with Quercetin inhibits the poly (dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-gamma-primed keratinocytes.	Quercetin	42-51	interferon gamma	Homo sapiens	210-219
30719246-7	2018	Results: Administration of quercetin and its nanocrystals (10 and 25 mg/kg) prevented disruption of memory, increased antioxidant enzyme activities (superoxide dismutase and catalase) and total glutathione and reduced Malondialdehyde (MDA) level in the hippocampal area.	Quercetin	27-36	catalase	Rattus norvegicus	174-182
30365230-5	2018	DEGS1 was increased by apigenin, luteolin, orobol, and quercetin administration.	Quercetin	55-64	delta(4)-desaturase, sphingolipid 1	Mus musculus	0-5
30171731-0	2018	Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARgamma signaling pathways.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	113-119
30171731-0	2018	Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARgamma signaling pathways.	Quercetin	0-9	Eph receptor B1	Rattus norvegicus	120-123
30171731-0	2018	Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARgamma signaling pathways.	Quercetin	0-9	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	124-133
30365230-7	2018	Pratensein induced both FADS1 and FADS2 in differentiated 3T3-L1 cells and DEGS1 was increased by treatment with apigenin, genistein, luteolin, orobol, and quercetin.	Quercetin	156-165	delta(4)-desaturase, sphingolipid 1	Mus musculus	75-80
30365230-4	2018	In HepG2 cells, FADS1 was induced by quercetin and FADS2 expression was increased by daidzein, genistein, and pratensein treatment.	Quercetin	37-46	fatty acid desaturase 1	Homo sapiens	16-21
30365230-9	2018	Apigenin, luteolin, orobol, and quercetin induced DEGS1 and thereby possibly synthesis of proapoptotic CER in malignant HepG2 cells and 3T3-L1.	Quercetin	32-41	delta 4-desaturase, sphingolipid 1	Homo sapiens	50-55
29627902-3	2018	The effect of rosmarinic acid was compared to quercetin, which is known to be a good Hsp27 inhibitor.	Quercetin	46-55	heat shock protein family B (small) member 1	Homo sapiens	85-90
29627902-6	2018	According to the results, it was found that RA and quercetin effectively silenced Hsp27 and both agents induced apoptosis by activating the caspase-3 pathway.	Quercetin	51-60	heat shock protein family B (small) member 1	Homo sapiens	82-87
29627902-6	2018	According to the results, it was found that RA and quercetin effectively silenced Hsp27 and both agents induced apoptosis by activating the caspase-3 pathway.	Quercetin	51-60	caspase 3	Homo sapiens	140-149
30010822-4	2018	Taxifolin and silymarin were "high binders" for ERalpha ligand binding; quercetin and curcumin were "high activators" for ERalpha transactivation.	Quercetin	72-81	estrogen receptor 1	Homo sapiens	122-129
30210596-0	2018	Quercetin is able to alleviate TGF-beta-induced fibrosis in renal tubular epithelial cells by suppressing miR-21.	Quercetin	0-9	transforming growth factor beta 1	Homo sapiens	31-39
29756176-0	2018	Response: Similar effect of quercetin on CYP2E1 and CYP2C9 activities in humans?	Quercetin	28-37	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	41-47
29756176-0	2018	Response: Similar effect of quercetin on CYP2E1 and CYP2C9 activities in humans?	Quercetin	28-37	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	52-58
29770840-0	2018	Similar effect of quercetin on CYP2E1 and CYP2C9 activities in humans?	Quercetin	18-27	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	31-37
29770840-0	2018	Similar effect of quercetin on CYP2E1 and CYP2C9 activities in humans?	Quercetin	18-27	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	42-48
30210596-0	2018	Quercetin is able to alleviate TGF-beta-induced fibrosis in renal tubular epithelial cells by suppressing miR-21.	Quercetin	0-9	microRNA 21	Homo sapiens	106-112
30210596-6	2018	Quercetin-treated cells were transfected with miR-21 mimics and the expression of fibrotic markers was examined using RT-qPCR.	Quercetin	0-9	microRNA 21	Homo sapiens	46-52
30210596-7	2018	Finally, the expression of fibrosis-associated miR-21 target genes, phosphatase and tensin homolog (PTEN) and TIMP Metallopeptidase Inhibitor 3 (TIMP3), was measured in cells treated with quercetin with or without miR-21 mimics using RT-qPCR, western blotting and immunocytochemistry.	Quercetin	188-197	microRNA 21	Homo sapiens	47-53
30210596-7	2018	Finally, the expression of fibrosis-associated miR-21 target genes, phosphatase and tensin homolog (PTEN) and TIMP Metallopeptidase Inhibitor 3 (TIMP3), was measured in cells treated with quercetin with or without miR-21 mimics using RT-qPCR, western blotting and immunocytochemistry.	Quercetin	188-197	phosphatase and tensin homolog	Homo sapiens	100-104
30210596-9	2018	Furthermore, quercetin treatment significantly inhibited TGF-beta-induced miR-21 upregulation and transfection with miR-21 mimics reversed the anti-fibrotic effects of quercetin.	Quercetin	13-22	transforming growth factor beta 1	Homo sapiens	57-65
30210596-9	2018	Furthermore, quercetin treatment significantly inhibited TGF-beta-induced miR-21 upregulation and transfection with miR-21 mimics reversed the anti-fibrotic effects of quercetin.	Quercetin	13-22	microRNA 21	Homo sapiens	74-80
30210596-9	2018	Furthermore, quercetin treatment significantly inhibited TGF-beta-induced miR-21 upregulation and transfection with miR-21 mimics reversed the anti-fibrotic effects of quercetin.	Quercetin	168-177	transforming growth factor beta 1	Homo sapiens	57-65
30210596-9	2018	Furthermore, quercetin treatment significantly inhibited TGF-beta-induced miR-21 upregulation and transfection with miR-21 mimics reversed the anti-fibrotic effects of quercetin.	Quercetin	168-177	microRNA 21	Homo sapiens	116-122
30210596-10	2018	Quercetin treatment markedly upregulated PTEN and TIMP3 expression, whereas transfection with miR-21 mimics reversed this effect.	Quercetin	0-9	phosphatase and tensin homolog	Homo sapiens	41-45
30210596-10	2018	Quercetin treatment markedly upregulated PTEN and TIMP3 expression, whereas transfection with miR-21 mimics reversed this effect.	Quercetin	0-9	TIMP metallopeptidase inhibitor 3	Homo sapiens	50-55
30210596-11	2018	The results of the present study suggest that quercetin is able to alleviate TGF-beta-induced fibrosis in HK-2 cells via suppressing the miR-21 and upregulating PTEN and TIMP3.	Quercetin	46-55	transforming growth factor beta 1	Homo sapiens	77-85
30210596-11	2018	The results of the present study suggest that quercetin is able to alleviate TGF-beta-induced fibrosis in HK-2 cells via suppressing the miR-21 and upregulating PTEN and TIMP3.	Quercetin	46-55	microRNA 21	Homo sapiens	137-143
30210596-11	2018	The results of the present study suggest that quercetin is able to alleviate TGF-beta-induced fibrosis in HK-2 cells via suppressing the miR-21 and upregulating PTEN and TIMP3.	Quercetin	46-55	phosphatase and tensin homolog	Homo sapiens	161-165
30210596-11	2018	The results of the present study suggest that quercetin is able to alleviate TGF-beta-induced fibrosis in HK-2 cells via suppressing the miR-21 and upregulating PTEN and TIMP3.	Quercetin	46-55	TIMP metallopeptidase inhibitor 3	Homo sapiens	170-175
30025823-0	2018	Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	85-88
29738867-4	2018	We have identified eight bioactive compounds (Apigenin, Dihydromyricetin, Diosmetin, Hesperidin, Hesperitin, Naringenin, Phlorizi, and Quercetin) as the potential inhibitors of PLK-1.	Quercetin	135-144	polo like kinase 1	Homo sapiens	177-182
30025823-0	2018	Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	89-93
30025823-4	2018	The corresponding western blot revealed that quercetin treatment down-regulated the expression of cell migration marker proteins, such as matrix metalloproteinase 2 (MMP-2), MMP-9 and vascular endothelial growth factor (VEGF).	Quercetin	45-54	matrix metallopeptidase 2	Homo sapiens	138-164
30025823-4	2018	The corresponding western blot revealed that quercetin treatment down-regulated the expression of cell migration marker proteins, such as matrix metalloproteinase 2 (MMP-2), MMP-9 and vascular endothelial growth factor (VEGF).	Quercetin	45-54	matrix metallopeptidase 2	Homo sapiens	166-171
30025823-4	2018	The corresponding western blot revealed that quercetin treatment down-regulated the expression of cell migration marker proteins, such as matrix metalloproteinase 2 (MMP-2), MMP-9 and vascular endothelial growth factor (VEGF).	Quercetin	45-54	matrix metallopeptidase 9	Homo sapiens	174-179
30025823-4	2018	The corresponding western blot revealed that quercetin treatment down-regulated the expression of cell migration marker proteins, such as matrix metalloproteinase 2 (MMP-2), MMP-9 and vascular endothelial growth factor (VEGF).	Quercetin	45-54	vascular endothelial growth factor A	Homo sapiens	184-218
30025823-4	2018	The corresponding western blot revealed that quercetin treatment down-regulated the expression of cell migration marker proteins, such as matrix metalloproteinase 2 (MMP-2), MMP-9 and vascular endothelial growth factor (VEGF).	Quercetin	45-54	vascular endothelial growth factor A	Homo sapiens	220-224
30025823-5	2018	The further experiments exhibited that quercetin successfully blocked cell glycolysis by inhibiting the level of glucose uptake and the production of lactic acid, and also decreased the level of glycolysis-related proteins Pyruvate kinase M2 (PKM2), Glucose transporter1(GLUT1) and Lactate dehydrogenase A (LDHA).	Quercetin	39-48	pyruvate kinase M1/2	Homo sapiens	223-241
29322353-8	2018	Our observation from the present research work reveals that Quercetin suppressed the production of proinflammatory cytokines at different levels, such as TNF-alpha and IL-1beta, and inhibits the activation of I-kappaB phosphorylation, whereas the total content was not affected.	Quercetin	60-69	tumor necrosis factor	Mus musculus	154-163
29322353-8	2018	Our observation from the present research work reveals that Quercetin suppressed the production of proinflammatory cytokines at different levels, such as TNF-alpha and IL-1beta, and inhibits the activation of I-kappaB phosphorylation, whereas the total content was not affected.	Quercetin	60-69	interleukin 1 beta	Mus musculus	168-176
30025823-5	2018	The further experiments exhibited that quercetin successfully blocked cell glycolysis by inhibiting the level of glucose uptake and the production of lactic acid, and also decreased the level of glycolysis-related proteins Pyruvate kinase M2 (PKM2), Glucose transporter1(GLUT1) and Lactate dehydrogenase A (LDHA).	Quercetin	39-48	pyruvate kinase M1/2	Homo sapiens	243-247
30025823-5	2018	The further experiments exhibited that quercetin successfully blocked cell glycolysis by inhibiting the level of glucose uptake and the production of lactic acid, and also decreased the level of glycolysis-related proteins Pyruvate kinase M2 (PKM2), Glucose transporter1(GLUT1) and Lactate dehydrogenase A (LDHA).	Quercetin	39-48	solute carrier family 2 member 1	Homo sapiens	271-276
30025823-5	2018	The further experiments exhibited that quercetin successfully blocked cell glycolysis by inhibiting the level of glucose uptake and the production of lactic acid, and also decreased the level of glycolysis-related proteins Pyruvate kinase M2 (PKM2), Glucose transporter1(GLUT1) and Lactate dehydrogenase A (LDHA).	Quercetin	39-48	lactate dehydrogenase A	Homo sapiens	282-305
30025823-5	2018	The further experiments exhibited that quercetin successfully blocked cell glycolysis by inhibiting the level of glucose uptake and the production of lactic acid, and also decreased the level of glycolysis-related proteins Pyruvate kinase M2 (PKM2), Glucose transporter1(GLUT1) and Lactate dehydrogenase A (LDHA).	Quercetin	39-48	lactate dehydrogenase A	Homo sapiens	307-311
30025823-7	2018	Moreover, our further investigation showed that quercetin induced obvious autophagy via inactivating the Akt-mTOR pathway.	Quercetin	48-57	AKT serine/threonine kinase 1	Homo sapiens	105-108
30025823-7	2018	Moreover, our further investigation showed that quercetin induced obvious autophagy via inactivating the Akt-mTOR pathway.	Quercetin	48-57	mechanistic target of rapamycin kinase	Homo sapiens	109-113
30025823-8	2018	At the same time, the application of autophagy inhibitor 3-MA and Akt-mTOR pathway inducer IGF-1 further demonstrated that quercetin exerted inhibiting effect on cell mobility and glycolysis through Akt-mTOR pathway mediated autophagy induction.	Quercetin	123-132	AKT serine/threonine kinase 1	Homo sapiens	66-69
30025823-8	2018	At the same time, the application of autophagy inhibitor 3-MA and Akt-mTOR pathway inducer IGF-1 further demonstrated that quercetin exerted inhibiting effect on cell mobility and glycolysis through Akt-mTOR pathway mediated autophagy induction.	Quercetin	123-132	mechanistic target of rapamycin kinase	Homo sapiens	70-74
30025823-8	2018	At the same time, the application of autophagy inhibitor 3-MA and Akt-mTOR pathway inducer IGF-1 further demonstrated that quercetin exerted inhibiting effect on cell mobility and glycolysis through Akt-mTOR pathway mediated autophagy induction.	Quercetin	123-132	insulin like growth factor 1	Homo sapiens	91-96
30025823-8	2018	At the same time, the application of autophagy inhibitor 3-MA and Akt-mTOR pathway inducer IGF-1 further demonstrated that quercetin exerted inhibiting effect on cell mobility and glycolysis through Akt-mTOR pathway mediated autophagy induction.	Quercetin	123-132	AKT serine/threonine kinase 1	Homo sapiens	199-202
30025823-8	2018	At the same time, the application of autophagy inhibitor 3-MA and Akt-mTOR pathway inducer IGF-1 further demonstrated that quercetin exerted inhibiting effect on cell mobility and glycolysis through Akt-mTOR pathway mediated autophagy induction.	Quercetin	123-132	mechanistic target of rapamycin kinase	Homo sapiens	203-207
30025823-9	2018	At last, the in vivo experiments also showed that quercetin treatment could suppress tumor growth and metastasis, inhibit glycolysis and induce autophagy through the inhibition of p-AKT/AKT.	Quercetin	50-59	AKT serine/threonine kinase 1	Homo sapiens	182-185
30025823-9	2018	At last, the in vivo experiments also showed that quercetin treatment could suppress tumor growth and metastasis, inhibit glycolysis and induce autophagy through the inhibition of p-AKT/AKT.	Quercetin	50-59	AKT serine/threonine kinase 1	Homo sapiens	186-189
30025823-10	2018	Taken together, we firstly revealed that quercetin suppressed the progression of breast cancer by inhibiting cell mobility and glycolysis through Akt-mTOR pathway mediated autophagy induction and may provide a potential therapeutic target for breast cancer treatment.	Quercetin	41-50	AKT serine/threonine kinase 1	Homo sapiens	146-149
30025823-10	2018	Taken together, we firstly revealed that quercetin suppressed the progression of breast cancer by inhibiting cell mobility and glycolysis through Akt-mTOR pathway mediated autophagy induction and may provide a potential therapeutic target for breast cancer treatment.	Quercetin	41-50	mechanistic target of rapamycin kinase	Homo sapiens	150-154
30074808-9	2018	Interfacial shear viscosity (eta i) measurements confirmed that a stronger film was formed at the interface with quercetin particles (eta i   25 N s m-1) rather than with curcumin particles (eta i   1.2 N s m-1) possibly because of the difference in the shape and size of the two crystals.	Quercetin	113-122	endothelin receptor type A	Homo sapiens	29-32
30074808-9	2018	Interfacial shear viscosity (eta i) measurements confirmed that a stronger film was formed at the interface with quercetin particles (eta i   25 N s m-1) rather than with curcumin particles (eta i   1.2 N s m-1) possibly because of the difference in the shape and size of the two crystals.	Quercetin	113-122	endothelin receptor type A	Homo sapiens	134-137
30074808-9	2018	Interfacial shear viscosity (eta i) measurements confirmed that a stronger film was formed at the interface with quercetin particles (eta i   25 N s m-1) rather than with curcumin particles (eta i   1.2 N s m-1) possibly because of the difference in the shape and size of the two crystals.	Quercetin	113-122	endothelin receptor type A	Homo sapiens	134-137
30016632-0	2018	Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-kappaB signaling in A549 cells.	Quercetin	0-9	toll like receptor 4	Homo sapiens	89-93
30016632-0	2018	Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-kappaB signaling in A549 cells.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	94-103
30016632-10	2018	In addition, the preventive effects are associated with downregulation of the TLR4/NF-kappaB signaling pathway, especially for quercetin and chrysin.	Quercetin	127-136	toll like receptor 4	Homo sapiens	78-82
30016632-7	2018	Furthermore, we found that quercetin and chrysin suppressed the mRNA and protein expression of TLR4 and Myd88.	Quercetin	27-36	toll like receptor 4	Homo sapiens	95-99
30016632-10	2018	In addition, the preventive effects are associated with downregulation of the TLR4/NF-kappaB signaling pathway, especially for quercetin and chrysin.	Quercetin	127-136	nuclear factor kappa B subunit 1	Homo sapiens	83-92
30016632-7	2018	Furthermore, we found that quercetin and chrysin suppressed the mRNA and protein expression of TLR4 and Myd88.	Quercetin	27-36	MYD88 innate immune signal transduction adaptor	Homo sapiens	104-109
30016632-8	2018	Consistently, quercetin and chrysin also decreased the phosphorylation of IKKbeta and IkappaB, the nuclear level of p65 (NF-kappaB) as well as the expression of MMP-9 in A549 cells exposed to Ni.	Quercetin	14-23	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	74-81
30016632-8	2018	Consistently, quercetin and chrysin also decreased the phosphorylation of IKKbeta and IkappaB, the nuclear level of p65 (NF-kappaB) as well as the expression of MMP-9 in A549 cells exposed to Ni.	Quercetin	14-23	RELA proto-oncogene, NF-kB subunit	Homo sapiens	116-119
30016632-8	2018	Consistently, quercetin and chrysin also decreased the phosphorylation of IKKbeta and IkappaB, the nuclear level of p65 (NF-kappaB) as well as the expression of MMP-9 in A549 cells exposed to Ni.	Quercetin	14-23	nuclear factor kappa B subunit 1	Homo sapiens	121-130
30016632-8	2018	Consistently, quercetin and chrysin also decreased the phosphorylation of IKKbeta and IkappaB, the nuclear level of p65 (NF-kappaB) as well as the expression of MMP-9 in A549 cells exposed to Ni.	Quercetin	14-23	matrix metallopeptidase 9	Homo sapiens	161-166
29993075-0	2018	Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation.	Quercetin	30-39	heme oxygenase 1	Homo sapiens	10-26
29993075-0	2018	Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation.	Quercetin	30-39	NLR family pyrin domain containing 3	Homo sapiens	102-107
29993075-10	2018	In conclusion, quercetin can preserve the function of the liver in acute alcoholic injury by upregulating the expression of IL-10 and HO-1 and thus inhibiting NLRP3 inflammasome activation and inflammatory factor secretion.	Quercetin	15-24	NLR family pyrin domain containing 3	Homo sapiens	159-164
29993075-6	2018	Quercetin could elevate the expression of nuclear factor E2-related factor 2(Nrf2)/HO-1 and ameliorate ethanol-induced acute liver injury in rats.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	77-81
29993075-6	2018	Quercetin could elevate the expression of nuclear factor E2-related factor 2(Nrf2)/HO-1 and ameliorate ethanol-induced acute liver injury in rats.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	83-87
29993075-7	2018	Moreover, this protective effect of quercetin could be diminished when combined with the HO-1 inhibitor ZnppIX which demonstrated a critical role of HO-1 in quercetin"s hepatoprotection.	Quercetin	36-45	heme oxygenase 1	Homo sapiens	149-153
29993075-7	2018	Moreover, this protective effect of quercetin could be diminished when combined with the HO-1 inhibitor ZnppIX which demonstrated a critical role of HO-1 in quercetin"s hepatoprotection.	Quercetin	157-166	heme oxygenase 1	Homo sapiens	89-93
29993075-7	2018	Moreover, this protective effect of quercetin could be diminished when combined with the HO-1 inhibitor ZnppIX which demonstrated a critical role of HO-1 in quercetin"s hepatoprotection.	Quercetin	157-166	heme oxygenase 1	Homo sapiens	149-153
29993075-8	2018	The underlying mechanism of quercetin"s benefit on the liver may be explained by its anti-oxidant properties and inhibitory effect on the ROS/NF-kappaB/NLRP3 inflammasome/IL-1beta and IL-18 pathway by inducing HO-1.	Quercetin	28-37	nuclear factor kappa B subunit 1	Homo sapiens	142-151
29993075-8	2018	The underlying mechanism of quercetin"s benefit on the liver may be explained by its anti-oxidant properties and inhibitory effect on the ROS/NF-kappaB/NLRP3 inflammasome/IL-1beta and IL-18 pathway by inducing HO-1.	Quercetin	28-37	NLR family pyrin domain containing 3	Homo sapiens	152-157
29993075-8	2018	The underlying mechanism of quercetin"s benefit on the liver may be explained by its anti-oxidant properties and inhibitory effect on the ROS/NF-kappaB/NLRP3 inflammasome/IL-1beta and IL-18 pathway by inducing HO-1.	Quercetin	28-37	interleukin 1 beta	Homo sapiens	171-179
29993075-8	2018	The underlying mechanism of quercetin"s benefit on the liver may be explained by its anti-oxidant properties and inhibitory effect on the ROS/NF-kappaB/NLRP3 inflammasome/IL-1beta and IL-18 pathway by inducing HO-1.	Quercetin	28-37	interleukin 18	Homo sapiens	184-189
29993075-8	2018	The underlying mechanism of quercetin"s benefit on the liver may be explained by its anti-oxidant properties and inhibitory effect on the ROS/NF-kappaB/NLRP3 inflammasome/IL-1beta and IL-18 pathway by inducing HO-1.	Quercetin	28-37	heme oxygenase 1	Homo sapiens	210-214
29993075-9	2018	Meanwhile, quercetin also upregulated the anti-inflammatory factor IL-10, while it was found uncorrelated with HO-1 expression.	Quercetin	11-20	interleukin 10	Homo sapiens	67-72
29993075-10	2018	In conclusion, quercetin can preserve the function of the liver in acute alcoholic injury by upregulating the expression of IL-10 and HO-1 and thus inhibiting NLRP3 inflammasome activation and inflammatory factor secretion.	Quercetin	15-24	interleukin 10	Homo sapiens	124-129
29993075-10	2018	In conclusion, quercetin can preserve the function of the liver in acute alcoholic injury by upregulating the expression of IL-10 and HO-1 and thus inhibiting NLRP3 inflammasome activation and inflammatory factor secretion.	Quercetin	15-24	heme oxygenase 1	Homo sapiens	134-138
29753749-4	2018	Further study revealed that quercetin inhibited the infiltration of CD68+ macrophages in renal interstitium.	Quercetin	28-37	CD68 molecule	Homo sapiens	68-72
30061214-0	2018	Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin.	Quercetin	101-110	cannabinoid receptor 1 (brain)	Mus musculus	0-22
30061214-1	2018	BACKGROUND/AIM: The expression of cannabinoid receptor-1 (CB1-R) seems to be modulated by bioactive natural components such as the flavonoid quercetin.	Quercetin	141-150	cannabinoid receptor 1 (brain)	Mus musculus	34-56
30061214-1	2018	BACKGROUND/AIM: The expression of cannabinoid receptor-1 (CB1-R) seems to be modulated by bioactive natural components such as the flavonoid quercetin.	Quercetin	141-150	cannabinoid receptor 1 (brain)	Mus musculus	58-61
30061214-2	2018	The aim of this study was to determine in an animal model of induced-colon cancer, whether quercetin inhibits colon carcinogenesis through changes in the expression of CB1-R.	Quercetin	91-100	cannabinoid receptor 1 (brain)	Mus musculus	168-173
30061214-5	2018	RESULTS: The diet supplemented with quercetin induced CB1-R gene expression and protein, inhibiting the protein levels of STAT3 and p-STAT3 (both mediators of cell proliferation).	Quercetin	36-45	cannabinoid receptor 1 (brain)	Mus musculus	54-59
30061214-5	2018	RESULTS: The diet supplemented with quercetin induced CB1-R gene expression and protein, inhibiting the protein levels of STAT3 and p-STAT3 (both mediators of cell proliferation).	Quercetin	36-45	signal transducer and activator of transcription 3	Mus musculus	122-127
30061214-5	2018	RESULTS: The diet supplemented with quercetin induced CB1-R gene expression and protein, inhibiting the protein levels of STAT3 and p-STAT3 (both mediators of cell proliferation).	Quercetin	36-45	signal transducer and activator of transcription 3	Mus musculus	134-139
30061214-6	2018	Dietary quercetin also caused a significant increase in Bax/Bcl2 ratio protein expression.	Quercetin	8-17	BCL2-associated X protein	Mus musculus	56-59
30061214-6	2018	Dietary quercetin also caused a significant increase in Bax/Bcl2 ratio protein expression.	Quercetin	8-17	B cell leukemia/lymphoma 2	Mus musculus	60-64
30061214-7	2018	CONCLUSION: The anti-proliferative and pro-apoptotic effects of quercetin in AOM-treated mice are mediated by induction of the protein and gene expression levels of CB1-R.	Quercetin	64-73	cannabinoid receptor 1 (brain)	Mus musculus	165-170
29857184-0	2018	Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1.	Quercetin	0-9	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	72-77
29753749-5	2018	Moreover, the decrease in levels of iNOS and IL-12, as well as the proportion of F4/80+/CD11b+/CD86+ macrophages, indicated quercetin-mediated inhibition of M1 macrophage polarization in the injured kidneys.	Quercetin	124-133	inositol-3-phosphate synthase 1	Homo sapiens	36-40
29857184-1	2018	Quercetin, a common dietary flavone, is a competitive inhibitor of glucose uptake and is also thought to be transported into cells by GLUT1.	Quercetin	0-9	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	134-139
29857184-2	2018	In this study, we confirm that quercetin is a competitive inhibitor of GLUT1 and also demonstrate that newly synthesized compounds, WZB-117 and BAY-876 are robust inhibitors of GLUT1 in L929 cells.	Quercetin	31-40	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	71-76
29753749-5	2018	Moreover, the decrease in levels of iNOS and IL-12, as well as the proportion of F4/80+/CD11b+/CD86+ macrophages, indicated quercetin-mediated inhibition of M1 macrophage polarization in the injured kidneys.	Quercetin	124-133	integrin subunit alpha M	Homo sapiens	88-93
29857184-2	2018	In this study, we confirm that quercetin is a competitive inhibitor of GLUT1 and also demonstrate that newly synthesized compounds, WZB-117 and BAY-876 are robust inhibitors of GLUT1 in L929 cells.	Quercetin	31-40	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	177-182
29857184-6	2018	This suggests that either quercetin is simply binding to surface GLUT1 or its transport in and out of the cell reaches equilibrium very quickly.	Quercetin	26-35	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	65-70
29753749-5	2018	Moreover, the decrease in levels of iNOS and IL-12, as well as the proportion of F4/80+/CD11b+/CD86+ macrophages, indicated quercetin-mediated inhibition of M1 macrophage polarization in the injured kidneys.	Quercetin	124-133	CD86 molecule	Homo sapiens	95-99
29857184-8	2018	However, we observed that WZB-117, an exofacial binding inhibitor of GLUT1 reduced quercetin interaction, while cytochalasin B, an endofacial binding inhibitor, enhanced quercetin interaction, and BAY-876 had no effect on quercetin interaction.	Quercetin	83-92	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	69-74
29857184-9	2018	Taken together, these data are more consistent with quercetin simply binding to GLUT1, but not actually being transported into L929 cells via the glucose channel in GLUT1.	Quercetin	52-61	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	80-85
29857184-9	2018	Taken together, these data are more consistent with quercetin simply binding to GLUT1, but not actually being transported into L929 cells via the glucose channel in GLUT1.	Quercetin	52-61	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	165-170
29753749-7	2018	Notably, quercetin-induced inhibitory effects on inflammatory macrophage polarization were associated with down-regulated activities of NF-kappaB p65 and IRF5, and thus led to the inactivation of upstream signaling TLR4/Myd88.	Quercetin	9-18	nuclear factor kappa B subunit 1	Homo sapiens	136-145
29753749-7	2018	Notably, quercetin-induced inhibitory effects on inflammatory macrophage polarization were associated with down-regulated activities of NF-kappaB p65 and IRF5, and thus led to the inactivation of upstream signaling TLR4/Myd88.	Quercetin	9-18	RELA proto-oncogene, NF-kB subunit	Homo sapiens	146-149
29753749-7	2018	Notably, quercetin-induced inhibitory effects on inflammatory macrophage polarization were associated with down-regulated activities of NF-kappaB p65 and IRF5, and thus led to the inactivation of upstream signaling TLR4/Myd88.	Quercetin	9-18	interferon regulatory factor 5	Homo sapiens	154-158
29753749-7	2018	Notably, quercetin-induced inhibitory effects on inflammatory macrophage polarization were associated with down-regulated activities of NF-kappaB p65 and IRF5, and thus led to the inactivation of upstream signaling TLR4/Myd88.	Quercetin	9-18	toll like receptor 4	Homo sapiens	215-219
29855745-8	2018	TUNEL assay showed an increase in apoptotic index (0.14 +- 0.03; 0.15 +- 0.01) in vanadium-quercetin treated groups as compared to the carcinogen control (0.02 +- 0.01) along with upregulation of Bcl-2 and downregulation of Bax and p53.	Quercetin	91-100	BCL2, apoptosis regulator	Rattus norvegicus	196-201
29753749-7	2018	Notably, quercetin-induced inhibitory effects on inflammatory macrophage polarization were associated with down-regulated activities of NF-kappaB p65 and IRF5, and thus led to the inactivation of upstream signaling TLR4/Myd88.	Quercetin	9-18	MYD88 innate immune signal transduction adaptor	Homo sapiens	220-225
29855745-8	2018	TUNEL assay showed an increase in apoptotic index (0.14 +- 0.03; 0.15 +- 0.01) in vanadium-quercetin treated groups as compared to the carcinogen control (0.02 +- 0.01) along with upregulation of Bcl-2 and downregulation of Bax and p53.	Quercetin	91-100	BCL2 associated X, apoptosis regulator	Rattus norvegicus	224-227
29753749-8	2018	Interestingly, quercetin also inhibited the polarization of F4/80+/CD11b+/CD206+ M2 macrophages, and reduced excessive accumulation of extracellular matrix and interstitial fibrosis by antagonizing the TGF-beta1/Smad2/3 signaling.	Quercetin	15-24	integrin subunit alpha M	Homo sapiens	67-72
29855745-8	2018	TUNEL assay showed an increase in apoptotic index (0.14 +- 0.03; 0.15 +- 0.01) in vanadium-quercetin treated groups as compared to the carcinogen control (0.02 +- 0.01) along with upregulation of Bcl-2 and downregulation of Bax and p53.	Quercetin	91-100	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	232-235
29753749-8	2018	Interestingly, quercetin also inhibited the polarization of F4/80+/CD11b+/CD206+ M2 macrophages, and reduced excessive accumulation of extracellular matrix and interstitial fibrosis by antagonizing the TGF-beta1/Smad2/3 signaling.	Quercetin	15-24	transforming growth factor beta 1	Homo sapiens	202-211
29753749-8	2018	Interestingly, quercetin also inhibited the polarization of F4/80+/CD11b+/CD206+ M2 macrophages, and reduced excessive accumulation of extracellular matrix and interstitial fibrosis by antagonizing the TGF-beta1/Smad2/3 signaling.	Quercetin	15-24	SMAD family member 2	Homo sapiens	212-219
30197123-8	2018	Our results showed that quercetin regulated iron absorption, despite SLC40 down-expression, indicating possible alternate route of iron transport, and that quercetin modulated iNOS production in splenic macrophages.	Quercetin	156-165	nitric oxide synthase 2	Rattus norvegicus	176-180
29800788-9	2018	In conclusion, the natural antioxidants oleuropein and quercetin counteract the Cyclo induced hepatotoxicity through activation of Nrf2/HO-1 signaling pathway with subsequent suppression of oxidative stress and inflammation.	Quercetin	55-64	NFE2 like bZIP transcription factor 2	Rattus norvegicus	131-135
29800788-9	2018	In conclusion, the natural antioxidants oleuropein and quercetin counteract the Cyclo induced hepatotoxicity through activation of Nrf2/HO-1 signaling pathway with subsequent suppression of oxidative stress and inflammation.	Quercetin	55-64	heme oxygenase 1	Rattus norvegicus	136-140
29800788-2	2018	This study was designed to investigate the possible cytoprotective effect of natural antioxidants as oleuropein and quercetin against Cyclo induced hepatotoxicity via the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway.	Quercetin	116-125	NFE2 like bZIP transcription factor 2	Rattus norvegicus	171-214
29800788-2	2018	This study was designed to investigate the possible cytoprotective effect of natural antioxidants as oleuropein and quercetin against Cyclo induced hepatotoxicity via the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway.	Quercetin	116-125	NFE2 like bZIP transcription factor 2	Rattus norvegicus	216-220
29800788-2	2018	This study was designed to investigate the possible cytoprotective effect of natural antioxidants as oleuropein and quercetin against Cyclo induced hepatotoxicity via the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway.	Quercetin	116-125	heme oxygenase 1	Rattus norvegicus	222-238
29800788-2	2018	This study was designed to investigate the possible cytoprotective effect of natural antioxidants as oleuropein and quercetin against Cyclo induced hepatotoxicity via the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway.	Quercetin	116-125	heme oxygenase 1	Rattus norvegicus	240-244
29596115-7	2018	Quercetin action is manifested by the upregulation of rhTRAIL-binding receptors DR4 and DR5 on the surface of cancer cells and by increased rate of the proteasome-mediated degradation of the antiapoptotic protein FLIP.	Quercetin	0-9	TNF receptor superfamily member 10a	Homo sapiens	80-83
28559152-7	2018	Hsp70 down-regulation by quercetin significantly recovered IFN-beta-induced apoptosis of NS5-expressing cells, correlating with the increase in the phosphorylation of ERK2, p38 MAPK, and STAT1.	Quercetin	25-34	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
28559152-7	2018	Hsp70 down-regulation by quercetin significantly recovered IFN-beta-induced apoptosis of NS5-expressing cells, correlating with the increase in the phosphorylation of ERK2, p38 MAPK, and STAT1.	Quercetin	25-34	interferon beta 1	Homo sapiens	59-67
28559152-7	2018	Hsp70 down-regulation by quercetin significantly recovered IFN-beta-induced apoptosis of NS5-expressing cells, correlating with the increase in the phosphorylation of ERK2, p38 MAPK, and STAT1.	Quercetin	25-34	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	89-92
28559152-7	2018	Hsp70 down-regulation by quercetin significantly recovered IFN-beta-induced apoptosis of NS5-expressing cells, correlating with the increase in the phosphorylation of ERK2, p38 MAPK, and STAT1.	Quercetin	25-34	mitogen-activated protein kinase 1	Homo sapiens	167-171
28559152-7	2018	Hsp70 down-regulation by quercetin significantly recovered IFN-beta-induced apoptosis of NS5-expressing cells, correlating with the increase in the phosphorylation of ERK2, p38 MAPK, and STAT1.	Quercetin	25-34	mitogen-activated protein kinase 1	Homo sapiens	173-176
28559152-7	2018	Hsp70 down-regulation by quercetin significantly recovered IFN-beta-induced apoptosis of NS5-expressing cells, correlating with the increase in the phosphorylation of ERK2, p38 MAPK, and STAT1.	Quercetin	25-34	mitogen-activated protein kinase 1	Homo sapiens	177-181
28559152-7	2018	Hsp70 down-regulation by quercetin significantly recovered IFN-beta-induced apoptosis of NS5-expressing cells, correlating with the increase in the phosphorylation of ERK2, p38 MAPK, and STAT1.	Quercetin	25-34	signal transducer and activator of transcription 1	Homo sapiens	187-192
29596115-7	2018	Quercetin action is manifested by the upregulation of rhTRAIL-binding receptors DR4 and DR5 on the surface of cancer cells and by increased rate of the proteasome-mediated degradation of the antiapoptotic protein FLIP.	Quercetin	0-9	TNF receptor superfamily member 10b	Homo sapiens	88-91
29568908-0	2018	Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKalpha/NF-kappaB and MAPK signaling pathways in otitis media.	Quercetin	0-9	C-X-C motif chemokine receptor 4	Homo sapiens	34-39
29671937-0	2018	Quercetin improves postpartum hypogalactia in milk-deficient mice via stimulating prolactin production in pituitary gland.	Quercetin	0-9	prolactin	Mus musculus	82-91
29671937-5	2018	Mechanically, quercetin, such as 17alpha-ethinyl estradiol, significantly stimulated prolactin (PRL) production and deposition in the mammary gland in the agalactosis mice determined by western blotting, quantitative polymerase chain reaction, and enzyme-linked immunosorbent assay, respectively.	Quercetin	14-23	prolactin	Mus musculus	85-94
29671937-5	2018	Mechanically, quercetin, such as 17alpha-ethinyl estradiol, significantly stimulated prolactin (PRL) production and deposition in the mammary gland in the agalactosis mice determined by western blotting, quantitative polymerase chain reaction, and enzyme-linked immunosorbent assay, respectively.	Quercetin	14-23	prolactin	Mus musculus	96-99
29671937-6	2018	Furthermore, quercetin could increase the expression of beta-casein, stearoyl-CoA desaturase, fatty acid synthase, and alpha-lactalbumin in the breast tissues that are responsible for the production of fatty acid, lactose, and galactose in the milk at the transcriptional level determined by quantitative polymerase chain reaction.	Quercetin	13-22	fatty acid synthase	Mus musculus	94-113
29671937-6	2018	Furthermore, quercetin could increase the expression of beta-casein, stearoyl-CoA desaturase, fatty acid synthase, and alpha-lactalbumin in the breast tissues that are responsible for the production of fatty acid, lactose, and galactose in the milk at the transcriptional level determined by quantitative polymerase chain reaction.	Quercetin	13-22	lactalbumin, alpha	Mus musculus	119-136
29671937-7	2018	Specifically, quercetin promoted primary mammary epithelial cell proliferation and stimulated prolactin receptor (PRLR) expression probably via AKT activation in vitro.	Quercetin	14-23	prolactin receptor	Mus musculus	94-112
29671937-7	2018	Specifically, quercetin promoted primary mammary epithelial cell proliferation and stimulated prolactin receptor (PRLR) expression probably via AKT activation in vitro.	Quercetin	14-23	prolactin receptor	Mus musculus	114-118
29671937-7	2018	Specifically, quercetin promoted primary mammary epithelial cell proliferation and stimulated prolactin receptor (PRLR) expression probably via AKT activation in vitro.	Quercetin	14-23	thymoma viral proto-oncogene 1	Mus musculus	144-147
29671937-8	2018	In conclusion, this study indicates that estrogen-like quercetin promotes mammary gland development and lactation yield in milk-deficient mice, probably via stimulating PRL expression and release from the pituitary gland, as well as induces PRLR expression in primary mammary epithelial cells.	Quercetin	55-64	prolactin	Mus musculus	169-172
29671937-8	2018	In conclusion, this study indicates that estrogen-like quercetin promotes mammary gland development and lactation yield in milk-deficient mice, probably via stimulating PRL expression and release from the pituitary gland, as well as induces PRLR expression in primary mammary epithelial cells.	Quercetin	55-64	prolactin receptor	Mus musculus	241-245
30086515-9	2018	Quercetin inhibited proliferation, apoptosis, and release of IGF-I, progesterone, and testosterone.	Quercetin	0-9	insulin like growth factor 1	Homo sapiens	61-66
30086515-10	2018	When administered with xylene, quercetin prevented the action of xylene on proliferation and IGF-I release, induced the stimulatory action of xylene on apoptosis, and promoted the effect of xylene on release of progesterone but not testosterone.	Quercetin	31-40	insulin like growth factor 1	Homo sapiens	93-98
30140227-5	2018	We also found that Qu-loaded TCs (QTCs) could notably enhance the effect of Qu on inhibiting the NF-kB/COX-2 signaling pathway as well as ameliorating the skin edema caused by UVB radiation.	Quercetin	19-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
30140227-5	2018	We also found that Qu-loaded TCs (QTCs) could notably enhance the effect of Qu on inhibiting the NF-kB/COX-2 signaling pathway as well as ameliorating the skin edema caused by UVB radiation.	Quercetin	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
29874597-2	2018	In this regard, we designed a novel multifunctional nano-sized drug delivery system based on LyP-1 peptide-modified low-molecular-weight heparin-quercetin conjugate (PLQ).	Quercetin	145-154	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	93-98
29874597-9	2018	STATEMENT OF SIGNIFICANCE: Herein, we successfully developed a novel amphiphilic nanomaterial, LyP-1-LMWH-Qu (PLQ) conjugate, consisting of a tumor-targeting moiety LyP-1, a hydrophobic quercetin (a multidrug resistance [MDR]-reversing drug) inner core, and a hydrophilic low-molecular-weight heparin (an antiangiogenic agent) outer shell for encapsulating and delivering a hydrophobic chemotherapeutic agent (gambogic acid).	Quercetin	186-195	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	95-100
30112361-1	2018	Aim: To evaluate the role of heat shock protein 70 (HSP70) on the MAPK pathway activation with quercetin treatment and its protection against small intestine impairments of heat stressed rats.	Quercetin	95-104	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	29-50
30112361-1	2018	Aim: To evaluate the role of heat shock protein 70 (HSP70) on the MAPK pathway activation with quercetin treatment and its protection against small intestine impairments of heat stressed rats.	Quercetin	95-104	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	52-57
30112361-9	2018	Inhibition of HSP70 by quercetin did not change intestinal permeability compared with the HS group but aggravated intestinal injury and affected the activation of MAPKs and caspase-3.	Quercetin	23-32	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	14-19
30112361-9	2018	Inhibition of HSP70 by quercetin did not change intestinal permeability compared with the HS group but aggravated intestinal injury and affected the activation of MAPKs and caspase-3.	Quercetin	23-32	caspase 3	Rattus norvegicus	173-182
29987270-4	2018	RESULTS Comparison of the findings of the model rats treated with quercetin (n=20) with non-treated model rats (n=10) showed reduced levels of fibroblast growth factor 23 (FGF23): normal group, 19.6 pg/ml; untreated group, 73.6 pg/ml; quercetin-treated group (5 mg/kg), 34.25 pg/ml; and quercetin-treated group (10 mg/kg), 21.3 pg/ml.	Quercetin	66-75	fibroblast growth factor 23	Rattus norvegicus	143-170
29987270-4	2018	RESULTS Comparison of the findings of the model rats treated with quercetin (n=20) with non-treated model rats (n=10) showed reduced levels of fibroblast growth factor 23 (FGF23): normal group, 19.6 pg/ml; untreated group, 73.6 pg/ml; quercetin-treated group (5 mg/kg), 34.25 pg/ml; and quercetin-treated group (10 mg/kg), 21.3 pg/ml.	Quercetin	66-75	fibroblast growth factor 23	Rattus norvegicus	172-177
29987270-5	2018	Quercetin-treated model rats had reduced serum levels of parathyroid hormone (PTH), inorganic phosphate, increased urine protein-to-creatinine ratio, increased urine antioxidants, serum lactate dehydrogenase (LDH), and interleukin (IL)-8 when compared with the untreated model group and the control group.	Quercetin	0-9	parathyroid hormone	Rattus norvegicus	57-76
29987270-8	2018	CONCLUSIONS In a rat model of adenine-induced chronic kidney disease, treatment with quercetin improved renal function, reduced oxidative stress factors, serum levels of FGF23, and kidney inflammation.	Quercetin	85-94	fibroblast growth factor 23	Rattus norvegicus	170-175
30026749-9	2018	No effect of resveratrol was found on both WM-sirtuin and hSIRT1 activities, while only a slight increase, up to about 20%, of hSIRT1 activity by quercetin was observed.	Quercetin	146-155	sirtuin 1	Homo sapiens	127-133
30069224-7	2018	Addition of quercetin to cell cultures caused suppression of NO production from HNEpCs after IL-4 stimulation.	Quercetin	12-21	interleukin 4	Homo sapiens	93-97
30069224-9	2018	Treatment of cells with quercetin at more than 1.0 nM suppressed STAT6 activation and iNOS mRNA expression induced by IL-4 stimulation.	Quercetin	24-33	signal transducer and activator of transcription 6	Homo sapiens	65-70
30069224-9	2018	Treatment of cells with quercetin at more than 1.0 nM suppressed STAT6 activation and iNOS mRNA expression induced by IL-4 stimulation.	Quercetin	24-33	nitric oxide synthase 2	Homo sapiens	86-90
30069224-9	2018	Treatment of cells with quercetin at more than 1.0 nM suppressed STAT6 activation and iNOS mRNA expression induced by IL-4 stimulation.	Quercetin	24-33	interleukin 4	Homo sapiens	118-122
30069224-10	2018	The present results strongly suggested that quercetin favorably modified the clinical condition of AR through the suppression of NO production from nasal epithelial cells after IL-4 stimulation.	Quercetin	44-53	interleukin 4	Homo sapiens	177-181
29864946-0	2018	Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	83-88
29864946-5	2018	Furthermore, the interlukin (IL)-1beta-induced accumulation of nitric oxide (NO), matrixmetalloproteinase (MMP)-3) and MMP-13 could be suppressed by quercetin.	Quercetin	149-158	interleukin 1 beta	Rattus norvegicus	17-38
29864946-5	2018	Furthermore, the interlukin (IL)-1beta-induced accumulation of nitric oxide (NO), matrixmetalloproteinase (MMP)-3) and MMP-13 could be suppressed by quercetin.	Quercetin	149-158	matrix metallopeptidase 3	Rattus norvegicus	82-113
29864946-6	2018	Finally, we confirmed that the therapeutic properties of quercetin on OA might function through the adenosine monophosphate-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway.	Quercetin	57-66	sirtuin 1	Rattus norvegicus	165-170
29935106-0	2018	Frataxin-Mediated PINK1-Parkin-Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin.	Quercetin	99-108	frataxin	Mus musculus	0-8
29935106-2	2018	However, it still remains elusive whether frataxin upregulation by quercetin contributes to the beneficial effect through mitophagy or not.	Quercetin	67-76	frataxin	Mus musculus	42-50
29935106-5	2018	Moreover, quercetin blocked mitophagy suppression by HFD based on the increased LC3II, PTEN-induced putative kinase 1 (PINK1) and Beclin1 expressions, as well as decreased p62 levels.	Quercetin	10-19	PTEN induced putative kinase 1	Mus musculus	87-117
29935106-5	2018	Moreover, quercetin blocked mitophagy suppression by HFD based on the increased LC3II, PTEN-induced putative kinase 1 (PINK1) and Beclin1 expressions, as well as decreased p62 levels.	Quercetin	10-19	PTEN induced putative kinase 1	Mus musculus	119-124
29935106-5	2018	Moreover, quercetin blocked mitophagy suppression by HFD based on the increased LC3II, PTEN-induced putative kinase 1 (PINK1) and Beclin1 expressions, as well as decreased p62 levels.	Quercetin	10-19	beclin 1, autophagy related	Mus musculus	130-137
29935106-5	2018	Moreover, quercetin blocked mitophagy suppression by HFD based on the increased LC3II, PTEN-induced putative kinase 1 (PINK1) and Beclin1 expressions, as well as decreased p62 levels.	Quercetin	10-19	nucleoporin 62	Mus musculus	172-175
29935106-7	2018	Specifically, frataxin was lowered in the liver of HFD-fed mice or HepG2 cell incubated with oleate/palmitate but restored by quercetin, and quercetin"s regulation of frataxin may depend on p53.	Quercetin	126-135	frataxin	Mus musculus	14-22
29935106-7	2018	Specifically, frataxin was lowered in the liver of HFD-fed mice or HepG2 cell incubated with oleate/palmitate but restored by quercetin, and quercetin"s regulation of frataxin may depend on p53.	Quercetin	141-150	frataxin	Mus musculus	14-22
29935106-7	2018	Specifically, frataxin was lowered in the liver of HFD-fed mice or HepG2 cell incubated with oleate/palmitate but restored by quercetin, and quercetin"s regulation of frataxin may depend on p53.	Quercetin	141-150	frataxin	Homo sapiens	167-175
29935106-7	2018	Specifically, frataxin was lowered in the liver of HFD-fed mice or HepG2 cell incubated with oleate/palmitate but restored by quercetin, and quercetin"s regulation of frataxin may depend on p53.	Quercetin	141-150	tumor protein p53	Homo sapiens	190-193
29935106-9	2018	Frataxin was further decreased by free fatty acids in knockdown cells concomitantly with depressed PINK1-Parkin-associated mitophagy, which was partially normalized by quercetin.	Quercetin	168-177	frataxin	Mus musculus	0-8
29935106-10	2018	CONCLUSION: Quercetin alleviated hepatic steatosis by enhancing frataxin-mediated PINK1/Parkin-dependent mitophagy, highlighting a promising preventive strategy and mechanism for NAFLD by quercetin.	Quercetin	12-21	frataxin	Mus musculus	64-72
29935106-10	2018	CONCLUSION: Quercetin alleviated hepatic steatosis by enhancing frataxin-mediated PINK1/Parkin-dependent mitophagy, highlighting a promising preventive strategy and mechanism for NAFLD by quercetin.	Quercetin	12-21	PTEN induced putative kinase 1	Mus musculus	82-87
29935106-10	2018	CONCLUSION: Quercetin alleviated hepatic steatosis by enhancing frataxin-mediated PINK1/Parkin-dependent mitophagy, highlighting a promising preventive strategy and mechanism for NAFLD by quercetin.	Quercetin	188-197	frataxin	Mus musculus	64-72
29635751-0	2018	Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	70-74
29635751-0	2018	Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation.	Quercetin	0-9	Y-box binding protein 1	Homo sapiens	132-136
29654614-0	2018	Quercetin protects against chronic prostatitis in rat model through NF-kappaB and MAPK signaling pathways.	Quercetin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	82-86
29654614-6	2018	Quercetin was identified to ameliorate the histo-pathologic changes, decrease the expression of pro-inflammatory cytokines IL-1beta, IL-2, IL-6, IL-17A, MCP1, and TNFalpha, improve anti-oxidant capacity, and suppress the phosphorylation of NF-kappaB and MAPKs.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	123-131
29654614-6	2018	Quercetin was identified to ameliorate the histo-pathologic changes, decrease the expression of pro-inflammatory cytokines IL-1beta, IL-2, IL-6, IL-17A, MCP1, and TNFalpha, improve anti-oxidant capacity, and suppress the phosphorylation of NF-kappaB and MAPKs.	Quercetin	0-9	interleukin 2	Rattus norvegicus	133-137
29654614-6	2018	Quercetin was identified to ameliorate the histo-pathologic changes, decrease the expression of pro-inflammatory cytokines IL-1beta, IL-2, IL-6, IL-17A, MCP1, and TNFalpha, improve anti-oxidant capacity, and suppress the phosphorylation of NF-kappaB and MAPKs.	Quercetin	0-9	interleukin 6	Rattus norvegicus	139-143
29654614-6	2018	Quercetin was identified to ameliorate the histo-pathologic changes, decrease the expression of pro-inflammatory cytokines IL-1beta, IL-2, IL-6, IL-17A, MCP1, and TNFalpha, improve anti-oxidant capacity, and suppress the phosphorylation of NF-kappaB and MAPKs.	Quercetin	0-9	interleukin 17A	Rattus norvegicus	145-151
29654614-6	2018	Quercetin was identified to ameliorate the histo-pathologic changes, decrease the expression of pro-inflammatory cytokines IL-1beta, IL-2, IL-6, IL-17A, MCP1, and TNFalpha, improve anti-oxidant capacity, and suppress the phosphorylation of NF-kappaB and MAPKs.	Quercetin	0-9	mast cell protease 1-like 1	Rattus norvegicus	153-157
29654614-6	2018	Quercetin was identified to ameliorate the histo-pathologic changes, decrease the expression of pro-inflammatory cytokines IL-1beta, IL-2, IL-6, IL-17A, MCP1, and TNFalpha, improve anti-oxidant capacity, and suppress the phosphorylation of NF-kappaB and MAPKs.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	163-171
29654614-7	2018	CONCLUSIONS: Quercetin has specific protective effect on CP/CPPS, which is mediated by anti-inflammation, anti-oxidation, and at least partly through NF-kappaB and MAPK signaling pathways.	Quercetin	13-22	mitogen activated protein kinase 3	Rattus norvegicus	164-168
30187880-0	2018	[Quercetin attenuates Ox-LDL-induced calcification in vascular smooth muscle cells by regulating ROS-TLR4 signaling pathway].	Quercetin	1-10	toll like receptor 4	Homo sapiens	101-105
30187880-7	2018	Quercetin treatment significantly attenuated Ox-LDL-induced VSMC calcification, reduced ALP activity, down-regulated the expression levels of Msx2, BMP2 and Osterix, and up-regulated the expressions of vascular smooth muscle contractile proteins SMA and SM22a.	Quercetin	0-9	ATHS	Homo sapiens	88-91
30187880-7	2018	Quercetin treatment significantly attenuated Ox-LDL-induced VSMC calcification, reduced ALP activity, down-regulated the expression levels of Msx2, BMP2 and Osterix, and up-regulated the expressions of vascular smooth muscle contractile proteins SMA and SM22a.	Quercetin	0-9	msh homeobox 2	Homo sapiens	142-146
30187880-7	2018	Quercetin treatment significantly attenuated Ox-LDL-induced VSMC calcification, reduced ALP activity, down-regulated the expression levels of Msx2, BMP2 and Osterix, and up-regulated the expressions of vascular smooth muscle contractile proteins SMA and SM22a.	Quercetin	0-9	bone morphogenetic protein 2	Homo sapiens	148-152
30187880-7	2018	Quercetin treatment significantly attenuated Ox-LDL-induced VSMC calcification, reduced ALP activity, down-regulated the expression levels of Msx2, BMP2 and Osterix, and up-regulated the expressions of vascular smooth muscle contractile proteins SMA and SM22a.	Quercetin	0-9	Sp7 transcription factor	Homo sapiens	157-164
30187880-7	2018	Quercetin treatment significantly attenuated Ox-LDL-induced VSMC calcification, reduced ALP activity, down-regulated the expression levels of Msx2, BMP2 and Osterix, and up-regulated the expressions of vascular smooth muscle contractile proteins SMA and SM22a.	Quercetin	0-9	survival of motor neuron 1, telomeric	Homo sapiens	246-249
30187880-7	2018	Quercetin treatment significantly attenuated Ox-LDL-induced VSMC calcification, reduced ALP activity, down-regulated the expression levels of Msx2, BMP2 and Osterix, and up-regulated the expressions of vascular smooth muscle contractile proteins SMA and SM22a.	Quercetin	0-9	transgelin	Homo sapiens	254-259
30187880-8	2018	In addition, Quercetin treatment markedly increased SOD activity, reduced ROS levels and TLR4 expression in VSMCs.	Quercetin	13-22	toll like receptor 4	Homo sapiens	89-93
30187880-10	2018	CONCLUSIONS: Quercetin inhibits Ox-LDL-induced VSMC calcification in VSMCs possibly by targeting the ROS/TLR4 signaling pathway.	Quercetin	13-22	toll like receptor 4	Homo sapiens	105-109
29678660-0	2018	Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway.	Quercetin	24-33	vascular endothelial growth factor A	Homo sapiens	100-104
29678660-0	2018	Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway.	Quercetin	24-33	AKT serine/threonine kinase 1	Homo sapiens	110-113
29678660-2	2018	Our findings showed that metformin in combination with quercetin synergistically inhibited the growth, migration and invasion of both PC-3 and LNCaP cells.	Quercetin	55-64	chromobox 8	Homo sapiens	134-138
29678660-5	2018	Our data also indicated that co-treatment of metformin and quercetin strongly inhibited the VEGF/Akt/PI3K pathway.	Quercetin	59-68	vascular endothelial growth factor A	Homo sapiens	92-96
29678660-5	2018	Our data also indicated that co-treatment of metformin and quercetin strongly inhibited the VEGF/Akt/PI3K pathway.	Quercetin	59-68	AKT serine/threonine kinase 1	Homo sapiens	97-100
29678660-7	2018	In conclusion, our findings indicate that the combination therapy of metformin and quercetin exerted synergistic antitumor effects in prostate cancers via inhibition of VEGF/Akt/PI3K pathway.	Quercetin	83-92	vascular endothelial growth factor A	Homo sapiens	169-173
29678660-7	2018	In conclusion, our findings indicate that the combination therapy of metformin and quercetin exerted synergistic antitumor effects in prostate cancers via inhibition of VEGF/Akt/PI3K pathway.	Quercetin	83-92	AKT serine/threonine kinase 1	Homo sapiens	174-177
29568908-0	2018	Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKalpha/NF-kappaB and MAPK signaling pathways in otitis media.	Quercetin	0-9	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	71-79
29568908-0	2018	Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKalpha/NF-kappaB and MAPK signaling pathways in otitis media.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	80-89
29568908-8	2018	Here, we report that quercetin suppressed NTHi-induced CXCR4 expression levels in vitro and in vivo.	Quercetin	21-30	C-X-C motif chemokine receptor 4	Homo sapiens	55-60
29568908-9	2018	Quercetin blocked CXCR4 activation through direct IKKbeta phosphorylation inhibition, as well as of p38 MAPK restraining.	Quercetin	0-9	C-X-C motif chemokine receptor 4	Homo sapiens	18-23
29568908-9	2018	Quercetin blocked CXCR4 activation through direct IKKbeta phosphorylation inhibition, as well as of p38 MAPK restraining.	Quercetin	0-9	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	50-57
29845234-0	2018	Quercetin protects against ox-LDL-induced injury via regulation of ABCAl, LXR-alpha and PCSK9 in RAW264.7 macrophages.	Quercetin	0-9	nuclear receptor subfamily 1, group H, member 3	Mus musculus	74-83
29188537-11	2018	The IFN-gamma and IL-4 cytokines were increased in the hyperlipidemic group when compared with control group, and decreased when hyperlipidemic rats received the pretreatment with quercetin.	Quercetin	180-189	interferon gamma	Rattus norvegicus	4-13
29188537-11	2018	The IFN-gamma and IL-4 cytokines were increased in the hyperlipidemic group when compared with control group, and decreased when hyperlipidemic rats received the pretreatment with quercetin.	Quercetin	180-189	interleukin 4	Rattus norvegicus	18-22
29749525-0	2018	Quercetin protects against inflammation, MMP-2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi-1 expression.	Quercetin	0-9	matrix metallopeptidase 2	Rattus norvegicus	41-46
29749525-0	2018	Quercetin protects against inflammation, MMP-2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi-1 expression.	Quercetin	0-9	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	147-152
29749525-6	2018	Treatment with quercetin significantly inhibited ROS generation, inflammation and MMP-2 protein expression in the rat model CPR.	Quercetin	15-24	matrix metallopeptidase 2	Rattus norvegicus	82-87
29749525-7	2018	Finally, quercetin significantly suppressed caspase-3 activity and activated Bmi-1 protein expression in the rat model of CPR.	Quercetin	9-18	caspase 3	Rattus norvegicus	44-53
29749525-7	2018	Finally, quercetin significantly suppressed caspase-3 activity and activated Bmi-1 protein expression in the rat model of CPR.	Quercetin	9-18	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	77-82
29976410-0	2018	Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction.	Quercetin	24-33	ribosomal protein S19	Homo sapiens	42-47
29976410-0	2018	Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction.	Quercetin	24-33	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
29976410-2	2018	In our previous report, luteolin and quercetin was shown to block Akt/mTOR/c-Myc signaling.	Quercetin	37-46	AKT serine/threonine kinase 1	Homo sapiens	66-69
29976410-2	2018	In our previous report, luteolin and quercetin was shown to block Akt/mTOR/c-Myc signaling.	Quercetin	37-46	mechanistic target of rapamycin kinase	Homo sapiens	70-74
29976410-2	2018	In our previous report, luteolin and quercetin was shown to block Akt/mTOR/c-Myc signaling.	Quercetin	37-46	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	75-80
29976410-3	2018	Here, we found luteolin and quercetin reduced protein level and transactivation activity of RPS19 in A431-III cells, which is isolated from parental A431 (A431-P) cell line.	Quercetin	28-37	ribosomal protein S19	Homo sapiens	92-97
29976410-4	2018	Further investigation the inhibitory mechanism of luteolin and quercetin on RPS19, we found c-Myc binding sites on RPS19 promoter.	Quercetin	63-72	ribosomal protein S19	Homo sapiens	76-81
29976410-4	2018	Further investigation the inhibitory mechanism of luteolin and quercetin on RPS19, we found c-Myc binding sites on RPS19 promoter.	Quercetin	63-72	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	92-97
29976410-4	2018	Further investigation the inhibitory mechanism of luteolin and quercetin on RPS19, we found c-Myc binding sites on RPS19 promoter.	Quercetin	63-72	ribosomal protein S19	Homo sapiens	115-120
29976410-9	2018	These data suggest that luteolin and quercetin might inhibit metastasis of cancer cells by blocking Akt/mTOR/c-Myc signaling pathway to suppress RPS19-activated EMT signaling.	Quercetin	37-46	AKT serine/threonine kinase 1	Homo sapiens	100-103
29976410-9	2018	These data suggest that luteolin and quercetin might inhibit metastasis of cancer cells by blocking Akt/mTOR/c-Myc signaling pathway to suppress RPS19-activated EMT signaling.	Quercetin	37-46	mechanistic target of rapamycin kinase	Homo sapiens	104-108
29976410-9	2018	These data suggest that luteolin and quercetin might inhibit metastasis of cancer cells by blocking Akt/mTOR/c-Myc signaling pathway to suppress RPS19-activated EMT signaling.	Quercetin	37-46	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	109-114
29976410-9	2018	These data suggest that luteolin and quercetin might inhibit metastasis of cancer cells by blocking Akt/mTOR/c-Myc signaling pathway to suppress RPS19-activated EMT signaling.	Quercetin	37-46	ribosomal protein S19	Homo sapiens	145-150
29845234-8	2018	It was concluded that quercetin inhibits ox-LDL-induced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXR-alpha and downregulation of PCSK9, p53, p21 and p16.	Quercetin	22-31	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	166-169
29845234-8	2018	It was concluded that quercetin inhibits ox-LDL-induced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXR-alpha and downregulation of PCSK9, p53, p21 and p16.	Quercetin	22-31	cyclin dependent kinase inhibitor 2A	Mus musculus	174-177
29749525-8	2018	The results demonstrated that quercetin protects against inflammation, MMP-2 activation and apoptosis induction in a rat model of CPR, and that this may be mediated by modulating Bmi-1 expression.	Quercetin	30-39	matrix metallopeptidase 2	Rattus norvegicus	71-76
29749525-8	2018	The results demonstrated that quercetin protects against inflammation, MMP-2 activation and apoptosis induction in a rat model of CPR, and that this may be mediated by modulating Bmi-1 expression.	Quercetin	30-39	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	179-184
29845234-0	2018	Quercetin protects against ox-LDL-induced injury via regulation of ABCAl, LXR-alpha and PCSK9 in RAW264.7 macrophages.	Quercetin	0-9	proprotein convertase subtilisin/kexin type 9	Mus musculus	88-93
29845234-3	2018	The present study measured the effects of quercetin on the expression of ATP-binding cassette transporter 1 (ABCAl), ATP-binding cassette sub-family G member 1 (ABCG1), liver X receptor-alpha (LXR-alpha), proprotein convertase subtilisin/kexin type 9 (PCSK9), p53, p21 and p16 induced by oxidized low density lipoprotein (ox-LDL).	Quercetin	42-51	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	73-107
29845234-3	2018	The present study measured the effects of quercetin on the expression of ATP-binding cassette transporter 1 (ABCAl), ATP-binding cassette sub-family G member 1 (ABCG1), liver X receptor-alpha (LXR-alpha), proprotein convertase subtilisin/kexin type 9 (PCSK9), p53, p21 and p16 induced by oxidized low density lipoprotein (ox-LDL).	Quercetin	42-51	ATP binding cassette subfamily G member 1	Mus musculus	161-166
29845234-8	2018	It was concluded that quercetin inhibits ox-LDL-induced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXR-alpha and downregulation of PCSK9, p53, p21 and p16.	Quercetin	22-31	ATP binding cassette subfamily G member 1	Mus musculus	115-120
29845234-8	2018	It was concluded that quercetin inhibits ox-LDL-induced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXR-alpha and downregulation of PCSK9, p53, p21 and p16.	Quercetin	22-31	nuclear receptor subfamily 1, group H, member 3	Mus musculus	122-131
29845234-8	2018	It was concluded that quercetin inhibits ox-LDL-induced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXR-alpha and downregulation of PCSK9, p53, p21 and p16.	Quercetin	22-31	proprotein convertase subtilisin/kexin type 9	Mus musculus	154-159
29845234-8	2018	It was concluded that quercetin inhibits ox-LDL-induced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXR-alpha and downregulation of PCSK9, p53, p21 and p16.	Quercetin	22-31	transformation related protein 53, pseudogene	Mus musculus	161-164
31089549-5	2018	Results: Dietary quercetin supplementation increased the level of UCP1 in both WAT and/or BAT of HFD-fed obese mice, which was accompanied by upregulated mRNA levels of thermogenesis-related genes.	Quercetin	17-26	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	66-70
29781726-0	2018	In-Vitro Analysis of Glucose and Quercetin Effects on m-TOR and Nrf-2 Expression in HepG2 Cell Line (Diabetes and Cancer Connection).	Quercetin	33-42	RAR related orphan receptor C	Homo sapiens	56-59
29781726-0	2018	In-Vitro Analysis of Glucose and Quercetin Effects on m-TOR and Nrf-2 Expression in HepG2 Cell Line (Diabetes and Cancer Connection).	Quercetin	33-42	NFE2 like bZIP transcription factor 2	Homo sapiens	64-69
29781726-2	2018	In this study, HepG2 cells have been used to investigate the toxic effects of hyperglycemia and/or quercetin (Q) on mammalian target of rapamycin (m-TOR) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression as central molecules involved in cancer.	Quercetin	99-108	mechanistic target of rapamycin kinase	Homo sapiens	116-145
29781726-2	2018	In this study, HepG2 cells have been used to investigate the toxic effects of hyperglycemia and/or quercetin (Q) on mammalian target of rapamycin (m-TOR) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression as central molecules involved in cancer.	Quercetin	99-108	RAR related orphan receptor C	Homo sapiens	149-152
29584932-4	2018	Simulations suggest that while quercetin and apigenin interact primarily with the same residues, the strength of interactions between specific AhR residues with CYP1A1 agonist, quercetin, in comparison with CYP1A1 antagonist, apigenin, is different; thus, such interactions are presumably indicative of potential switches for modulating CYP1A1 activity.	Quercetin	177-186	aryl hydrocarbon receptor	Homo sapiens	143-146
29584932-4	2018	Simulations suggest that while quercetin and apigenin interact primarily with the same residues, the strength of interactions between specific AhR residues with CYP1A1 agonist, quercetin, in comparison with CYP1A1 antagonist, apigenin, is different; thus, such interactions are presumably indicative of potential switches for modulating CYP1A1 activity.	Quercetin	177-186	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	161-167
29914627-8	2018	During the demyelination, quercetin promoted the increase in acetylcholinesterase activity in whole blood and lymphocytes induced by EB, and it reduced the increase in acetylcholinesterase activity in lymphocytes in the remyelination phase.	Quercetin	26-35	acetylcholinesterase	Rattus norvegicus	61-81
29914627-8	2018	During the demyelination, quercetin promoted the increase in acetylcholinesterase activity in whole blood and lymphocytes induced by EB, and it reduced the increase in acetylcholinesterase activity in lymphocytes in the remyelination phase.	Quercetin	26-35	acetylcholinesterase	Rattus norvegicus	168-188
31089549-0	2018	Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation.	Quercetin	0-9	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	22-42
31089549-2	2018	In this study, we investigated the effect of quercetin, a naturally occurring flavonoid, on UCP1 expression in white/brown adipose tissues (WAT/BAT).	Quercetin	45-54	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	92-96
31089549-5	2018	Results: Dietary quercetin supplementation increased the level of UCP1 in both WAT and/or BAT of HFD-fed obese mice, which was accompanied by upregulated mRNA levels of thermogenesis-related genes.	Quercetin	17-26	bile acid-Coenzyme A: amino acid N-acyltransferase	Mus musculus	90-93
31089549-7	2018	Moreover, quercetin enhanced UCP1 expression in 3T3-L1 adipocytes, and this was blunted by treatment with a peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist.	Quercetin	10-19	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	29-33
31089549-7	2018	Moreover, quercetin enhanced UCP1 expression in 3T3-L1 adipocytes, and this was blunted by treatment with a peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist.	Quercetin	10-19	peroxisome proliferator activated receptor gamma	Mus musculus	108-156
31089549-7	2018	Moreover, quercetin enhanced UCP1 expression in 3T3-L1 adipocytes, and this was blunted by treatment with a peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist.	Quercetin	10-19	peroxisome proliferator activated receptor gamma	Mus musculus	158-167
31089549-8	2018	Conclusion: These findings suggest that quercetin upregulates UCP1, implying increased WAT browning and BAT activity, via activation of the AMPK/PPARgamma pathway through sympathetic stimulation.	Quercetin	40-49	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	62-66
31089549-8	2018	Conclusion: These findings suggest that quercetin upregulates UCP1, implying increased WAT browning and BAT activity, via activation of the AMPK/PPARgamma pathway through sympathetic stimulation.	Quercetin	40-49	bile acid-Coenzyme A: amino acid N-acyltransferase	Mus musculus	104-107
31089549-8	2018	Conclusion: These findings suggest that quercetin upregulates UCP1, implying increased WAT browning and BAT activity, via activation of the AMPK/PPARgamma pathway through sympathetic stimulation.	Quercetin	40-49	peroxisome proliferator activated receptor gamma	Mus musculus	145-154
29958399-3	2018	This study investigated the effects of quercetin on Astragalus polysaccharide RAP induced-macrophage activation.	Quercetin	39-48	regulatory associated protein of MTOR, complex 1	Mus musculus	78-81
29958399-4	2018	The results show quercetin decreases the NO production and iNOS gene expression in RAW264.7 cells, and it inhibits the production of cytokines in RAW264.7 cells and peritoneal macrophages.	Quercetin	17-26	nitric oxide synthase 2, inducible	Mus musculus	59-63
29958399-5	2018	Western blot analysis results suggest that quercetin inhibits the phosphorylation of Akt/mTORC1, MAPKs, and TBK1, but has no effect on NF-kappaB in RAP-induced RAW264.7 cells.	Quercetin	43-52	thymoma viral proto-oncogene 1	Mus musculus	85-88
29958399-5	2018	Western blot analysis results suggest that quercetin inhibits the phosphorylation of Akt/mTORC1, MAPKs, and TBK1, but has no effect on NF-kappaB in RAP-induced RAW264.7 cells.	Quercetin	43-52	CREB regulated transcription coactivator 1	Mus musculus	89-95
29958399-5	2018	Western blot analysis results suggest that quercetin inhibits the phosphorylation of Akt/mTORC1, MAPKs, and TBK1, but has no effect on NF-kappaB in RAP-induced RAW264.7 cells.	Quercetin	43-52	TANK-binding kinase 1	Mus musculus	108-112
29958399-6	2018	Taken together, the results show that quercetin partly inhibits macrophage activation by the Astragalus polysaccharide RAP.	Quercetin	38-47	regulatory associated protein of MTOR, complex 1	Mus musculus	119-122
29958399-7	2018	This study demonstrates that quercetin-containing foods may interfere with the immune-enhancing effects of Astragalus polysaccharide RAP to a certain extent.	Quercetin	29-38	regulatory associated protein of MTOR, complex 1	Mus musculus	133-136
29914151-7	2018	Rather, quercetin induced a slight reduction in liver Apob expression (-13%, p &lt; 0.05), which suggests decreased very-low density lipoprotein-TG production.	Quercetin	8-17	apolipoprotein B	Mus musculus	54-58
29914151-9	2018	Furthermore, quercetin also markedly increased mRNA expression of Ucp1 (+229%, p &lt; 0.05) and Elovl3 (+138%, p &lt; 0.05), specifically in sWAT.	Quercetin	13-22	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	66-70
29914151-9	2018	Furthermore, quercetin also markedly increased mRNA expression of Ucp1 (+229%, p &lt; 0.05) and Elovl3 (+138%, p &lt; 0.05), specifically in sWAT.	Quercetin	13-22	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	96-102
29621523-5	2018	In addition, quercetin affected oxidative stress parameters as glutathione oxidation, and the activities of oxidant detoxifying enzymes superoxide dismutase, glutathione peroxidase, and catalase.	Quercetin	13-22	catalase	Rattus norvegicus	186-194
29898731-12	2018	PCa cells with mutated p53 (DU-145) and increased ROS showed significant reduction in the activation of pro-survival Akt pathway while Raf/MEK were activated in response to quercetin.	Quercetin	173-182	tumor protein p53	Homo sapiens	23-26
29898731-12	2018	PCa cells with mutated p53 (DU-145) and increased ROS showed significant reduction in the activation of pro-survival Akt pathway while Raf/MEK were activated in response to quercetin.	Quercetin	173-182	mitogen-activated protein kinase kinase 7	Homo sapiens	139-142
29898731-15	2018	CONCLUSIONS: Our results demonstrated quercetin exerts its anti-cancer effects by modulating ROS, Akt, and NF-kappaB pathways.	Quercetin	38-47	AKT serine/threonine kinase 1	Homo sapiens	98-101
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Quercetin	32-41	interleukin 6	Homo sapiens	173-177
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Quercetin	32-41	tumor necrosis factor	Homo sapiens	179-188
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Quercetin	32-41	interleukin 1 alpha	Homo sapiens	190-198
28923363-4	2018	In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2), down-regulate inflammatory markers and prevent neural damage.	Quercetin	32-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-208
29512831-8	2018	Quercetin or rutin co-treatment with SASP significantly reversed organ weights, preserved sperm integrity, restored plasma hormone levels and increased cholesterol levels, 3beta-HSD and 17beta-HSD activities in testis.	Quercetin	0-9	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	172-181
29512831-8	2018	Quercetin or rutin co-treatment with SASP significantly reversed organ weights, preserved sperm integrity, restored plasma hormone levels and increased cholesterol levels, 3beta-HSD and 17beta-HSD activities in testis.	Quercetin	0-9	aldo-keto reductase family 1, member C12	Rattus norvegicus	186-196
29554596-7	2018	These molecular effects of quercetin were related to the inhibition of the nuclear factor kappa-B and induction of Nuclear factor erythroid 2- related factor (Nrf2)/home oxygenase (HO-1) pathway.	Quercetin	27-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	159-163
29548810-10	2018	In the X. laevis oocyte model, GLUT2-mediated glucose and fructose transport were inhibited by quercetin, (-)-epigallocatechin gallate (EGCG) and apigenin, GLUT5-mediated fructose transport was inhibited by apigenin and EGCG, but not by quercetin, and GLUT7-mediated uptake of both glucose and fructose was inhibited by apigenin, but not by quercetin nor EGCG.	Quercetin	95-104	solute carrier family 2 member 2 L homeolog	Xenopus laevis	31-36
29548810-10	2018	In the X. laevis oocyte model, GLUT2-mediated glucose and fructose transport were inhibited by quercetin, (-)-epigallocatechin gallate (EGCG) and apigenin, GLUT5-mediated fructose transport was inhibited by apigenin and EGCG, but not by quercetin, and GLUT7-mediated uptake of both glucose and fructose was inhibited by apigenin, but not by quercetin nor EGCG.	Quercetin	95-104	solute carrier family 2 member 7	Homo sapiens	252-257
29548810-10	2018	In the X. laevis oocyte model, GLUT2-mediated glucose and fructose transport were inhibited by quercetin, (-)-epigallocatechin gallate (EGCG) and apigenin, GLUT5-mediated fructose transport was inhibited by apigenin and EGCG, but not by quercetin, and GLUT7-mediated uptake of both glucose and fructose was inhibited by apigenin, but not by quercetin nor EGCG.	Quercetin	237-246	solute carrier family 2 member 2 L homeolog	Xenopus laevis	31-36
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Quercetin	19-28	tumor necrosis factor	Mus musculus	107-115
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Quercetin	19-28	interleukin 1 beta	Mus musculus	120-128
30035737-4	2018	In contrast to Spasmex, Mirabegron and Quercetin in combination with Testosterone and Estradiol contributed to stabilization of eNOS and nNOs expression already at early observation phases, and reduced the level of iNOS expression with its further disappearance in the later observation period.	Quercetin	39-48	nitric oxide synthase 1	Homo sapiens	137-141
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Quercetin	19-28	cytochrome b-245, beta polypeptide	Mus musculus	145-153
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Quercetin	19-28	endothelin 1	Mus musculus	155-174
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Quercetin	19-28	endothelin 1	Mus musculus	176-186
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Quercetin	19-28	prostaglandin-endoperoxide synthase 2	Mus musculus	193-209
29548810-10	2018	In the X. laevis oocyte model, GLUT2-mediated glucose and fructose transport were inhibited by quercetin, (-)-epigallocatechin gallate (EGCG) and apigenin, GLUT5-mediated fructose transport was inhibited by apigenin and EGCG, but not by quercetin, and GLUT7-mediated uptake of both glucose and fructose was inhibited by apigenin, but not by quercetin nor EGCG.	Quercetin	237-246	solute carrier family 2 member 2 L homeolog	Xenopus laevis	31-36
29393507-12	2018	The HuR inhibitor, quercetin, suppressed Pg-induced HuR mRNA expression and IL-6 production in OBA-9.	Quercetin	19-28	interleukin 6	Mus musculus	76-80
29393507-13	2018	An oral inoculation with quercetin also inhibited bone resorption in ligature-induced periodontitis model mice as a result of down-regulation of IL-6.	Quercetin	25-34	interleukin 6	Mus musculus	145-149
28681665-0	2018	Stimulatory effects of curcumin and quercetin on posttranslational modifications of p53 during lung carcinogenesis.	Quercetin	36-45	transformation related protein 53, pseudogene	Mus musculus	84-87
30035737-4	2018	In contrast to Spasmex, Mirabegron and Quercetin in combination with Testosterone and Estradiol contributed to stabilization of eNOS and nNOs expression already at early observation phases, and reduced the level of iNOS expression with its further disappearance in the later observation period.	Quercetin	39-48	nitric oxide synthase 2	Homo sapiens	215-219
28681665-5	2018	Curcumin and quercetin when administered individually as well as in combination significantly elevated the expression of acetylated-p53, which was otherwise depressed due to BP treatment.	Quercetin	13-22	transformation related protein 53, pseudogene	Mus musculus	132-135
28681665-9	2018	The present study concludes that prophylactic treatment with curcumin and quercetin induces apoptosis in the lungs by modulation of p53 posttranslational modifications.	Quercetin	74-83	transformation related protein 53, pseudogene	Mus musculus	132-135
29569077-0	2018	Protective Effect of Quercetin in LPS-Induced Murine Acute Lung Injury Mediated by cAMP-Epac Pathway.	Quercetin	21-30	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	88-92
28627240-0	2018	Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-kappab, PKC-delta, ERK1/2, and AMPKalpha.	Quercetin	0-9	plasminogen activator, urokinase	Homo sapiens	85-88
28627240-0	2018	Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-kappab, PKC-delta, ERK1/2, and AMPKalpha.	Quercetin	0-9	plasminogen activator, urokinase receptor	Homo sapiens	89-93
28627240-0	2018	Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-kappab, PKC-delta, ERK1/2, and AMPKalpha.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	117-126
28627240-0	2018	Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-kappab, PKC-delta, ERK1/2, and AMPKalpha.	Quercetin	0-9	protein kinase C delta	Homo sapiens	128-137
28627240-0	2018	Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-kappab, PKC-delta, ERK1/2, and AMPKalpha.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	139-145
29569982-4	2018	In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes.	Quercetin	32-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	252-295
29569982-4	2018	In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes.	Quercetin	32-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	297-301
29569982-5	2018	The HO-1 inhibitor ZnPP suppressed the inhibitory actions of quercetin on TNFalpha-induced atrophic responses and degradation of IkappaB-alpha in myotubes.	Quercetin	61-70	heme oxygenase 1	Mus musculus	4-8
29569982-5	2018	The HO-1 inhibitor ZnPP suppressed the inhibitory actions of quercetin on TNFalpha-induced atrophic responses and degradation of IkappaB-alpha in myotubes.	Quercetin	61-70	tumor necrosis factor	Mus musculus	74-82
29569982-5	2018	The HO-1 inhibitor ZnPP suppressed the inhibitory actions of quercetin on TNFalpha-induced atrophic responses and degradation of IkappaB-alpha in myotubes.	Quercetin	61-70	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	129-142
29569982-6	2018	Moreover, quercetin supplementation to high-fat diet-fed obese mice inhibited obesity-induced atrophic responses in skeletal muscle, accompanied by upregulation of HO-1 and inactivation of nuclear factor-kappa B (NF-kappaB), and the quercetin actions were attenuated in Nrf2-deficient mice.	Quercetin	10-19	heme oxygenase 1	Mus musculus	164-168
29569982-6	2018	Moreover, quercetin supplementation to high-fat diet-fed obese mice inhibited obesity-induced atrophic responses in skeletal muscle, accompanied by upregulation of HO-1 and inactivation of nuclear factor-kappa B (NF-kappaB), and the quercetin actions were attenuated in Nrf2-deficient mice.	Quercetin	10-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	189-211
29569982-6	2018	Moreover, quercetin supplementation to high-fat diet-fed obese mice inhibited obesity-induced atrophic responses in skeletal muscle, accompanied by upregulation of HO-1 and inactivation of nuclear factor-kappa B (NF-kappaB), and the quercetin actions were attenuated in Nrf2-deficient mice.	Quercetin	10-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	213-222
29569982-6	2018	Moreover, quercetin supplementation to high-fat diet-fed obese mice inhibited obesity-induced atrophic responses in skeletal muscle, accompanied by upregulation of HO-1 and inactivation of nuclear factor-kappa B (NF-kappaB), and the quercetin actions were attenuated in Nrf2-deficient mice.	Quercetin	10-19	nuclear factor, erythroid derived 2, like 2	Mus musculus	270-274
29569982-6	2018	Moreover, quercetin supplementation to high-fat diet-fed obese mice inhibited obesity-induced atrophic responses in skeletal muscle, accompanied by upregulation of HO-1 and inactivation of nuclear factor-kappa B (NF-kappaB), and the quercetin actions were attenuated in Nrf2-deficient mice.	Quercetin	233-242	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	213-222
29569982-7	2018	These findings suggest that quercetin protects against TNFalpha-induced muscle atrophy under obese conditions through Nrf2-mediated HO-1 induction accompanied by inactivation of NF-kappaB.	Quercetin	28-37	tumor necrosis factor	Mus musculus	55-63
29569982-7	2018	These findings suggest that quercetin protects against TNFalpha-induced muscle atrophy under obese conditions through Nrf2-mediated HO-1 induction accompanied by inactivation of NF-kappaB.	Quercetin	28-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	118-122
29569982-7	2018	These findings suggest that quercetin protects against TNFalpha-induced muscle atrophy under obese conditions through Nrf2-mediated HO-1 induction accompanied by inactivation of NF-kappaB.	Quercetin	28-37	heme oxygenase 1	Mus musculus	132-136
29569982-7	2018	These findings suggest that quercetin protects against TNFalpha-induced muscle atrophy under obese conditions through Nrf2-mediated HO-1 induction accompanied by inactivation of NF-kappaB.	Quercetin	28-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	178-187
29569982-0	2018	Quercetin Reduces Tumor Necrosis Factor Alpha-Induced Muscle Atrophy by Upregulation of Heme Oxygenase-1.	Quercetin	0-9	tumor necrosis factor	Mus musculus	18-45
29569982-0	2018	Quercetin Reduces Tumor Necrosis Factor Alpha-Induced Muscle Atrophy by Upregulation of Heme Oxygenase-1.	Quercetin	0-9	heme oxygenase 1	Mus musculus	88-104
29569982-3	2018	In this study, we investigated the effect of quercetin on TNFalpha-induced skeletal muscle atrophy as well as its potential mechanism of action.	Quercetin	45-54	tumor necrosis factor	Mus musculus	58-66
29569982-4	2018	In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes.	Quercetin	32-41	tumor necrosis factor	Mus musculus	67-75
29569982-4	2018	In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes.	Quercetin	32-41	F-box protein 32	Mus musculus	109-114
29569982-4	2018	In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes.	Quercetin	32-41	F-box protein 32	Mus musculus	115-124
29569982-4	2018	In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes.	Quercetin	32-41	tripartite motif-containing 63	Mus musculus	129-134
29569982-4	2018	In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes.	Quercetin	32-41	heme oxygenase 1	Mus musculus	164-180
29569982-4	2018	In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes.	Quercetin	32-41	heme oxygenase 1	Mus musculus	182-186
29569077-1	2018	Quercetin (Que) as an abundant flavonol element possesses potent antioxidative properties and has protective effect in lipopolysaccharide (LPS)-induced acute lung injury (ALI), but the specific mechanism is still unclear, so we investigated the effect of Que from in vivo and in vitro studies and the related mechanism of cAMP-PKA/Epac pathway.	Quercetin	0-9	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	331-335
29569077-1	2018	Quercetin (Que) as an abundant flavonol element possesses potent antioxidative properties and has protective effect in lipopolysaccharide (LPS)-induced acute lung injury (ALI), but the specific mechanism is still unclear, so we investigated the effect of Que from in vivo and in vitro studies and the related mechanism of cAMP-PKA/Epac pathway.	Quercetin	0-3	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	331-335
29569077-1	2018	Quercetin (Que) as an abundant flavonol element possesses potent antioxidative properties and has protective effect in lipopolysaccharide (LPS)-induced acute lung injury (ALI), but the specific mechanism is still unclear, so we investigated the effect of Que from in vivo and in vitro studies and the related mechanism of cAMP-PKA/Epac pathway.	Quercetin	11-14	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	331-335
29569077-4	2018	The results in epithelial cell (MLE-12) suggested that Que also can inhibit the inflammatory mediators keratinocyte-derived chemokines release after LPS stimulation; Epac inhibitor ESI-09 functionally antagonizes the inhibitory effect of Que; meanwhile, PKA inhibitor H89 functionally enhances the inhibitory effect of Que.	Quercetin	55-58	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	166-170
29569077-4	2018	The results in epithelial cell (MLE-12) suggested that Que also can inhibit the inflammatory mediators keratinocyte-derived chemokines release after LPS stimulation; Epac inhibitor ESI-09 functionally antagonizes the inhibitory effect of Que; meanwhile, PKA inhibitor H89 functionally enhances the inhibitory effect of Que.	Quercetin	238-241	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	166-170
29569077-4	2018	The results in epithelial cell (MLE-12) suggested that Que also can inhibit the inflammatory mediators keratinocyte-derived chemokines release after LPS stimulation; Epac inhibitor ESI-09 functionally antagonizes the inhibitory effect of Que; meanwhile, PKA inhibitor H89 functionally enhances the inhibitory effect of Que.	Quercetin	238-241	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	166-170
29569077-6	2018	All those results suggested that the protective effect of quercetin in ALI is involved in cAMP-Epac pathway.	Quercetin	58-67	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	95-99
29620218-9	2018	Additionally, quercetin caused a marked inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and activated Akt serine/threonine protein kinase phosphorylation, which may result in attenuation of neuronal apoptosis.	Quercetin	14-23	mitogen activated protein kinase 3	Rattus norvegicus	54-93
29928342-4	2018	In the present study, the effect of quercetin on the cell death via the induction of apoptosis in human oral cancer SAS cells was investigated using flow cytometry, Annexin V/propidium iodide (PI) double staining, western blotting and confocal laser microscopy examination, to test for cytotoxic effects at 6-48 h after treatment with quercetin.	Quercetin	36-45	annexin A5	Homo sapiens	165-174
29928342-5	2018	The rate of cell death increased with the duration of quercetin treatment based on the results of a cell viability assay, increased Annexin V/PI staining, increased reactive oxygen species and Ca2+ production, decreased the levels of mitochondrial membrane potential (DeltaPsim), increased proportion of apoptotic cells and altered levels of apoptosis-associated protein expression in SAS cells.	Quercetin	54-63	annexin A5	Homo sapiens	132-141
29928342-6	2018	The results from western blotting revealed that quercetin increased Fas, Fas-Ligand, fas-associated protein with death domain and caspase-8, all of which associated with cell surface death receptor.	Quercetin	48-57	Fas ligand	Homo sapiens	73-107
29928342-6	2018	The results from western blotting revealed that quercetin increased Fas, Fas-Ligand, fas-associated protein with death domain and caspase-8, all of which associated with cell surface death receptor.	Quercetin	48-57	caspase 8	Homo sapiens	130-139
29928342-7	2018	Furthermore, quercetin increased the levels of activating transcription factor (ATF)-6alpha, ATF-6beta and gastrin-releasing peptide-78 which indicated an increase in endoplasm reticulum stress, increased levels of the pro-apoptotic protein BH3 interacting-domain death antagonist, and decreased levels of anti-apoptotic proteins B-cell lymphoma (Bcl) 2 and Bcl-extra large which may have led to the decreases of DeltaPsim.	Quercetin	13-22	activating transcription factor 6	Homo sapiens	47-91
29928342-7	2018	Furthermore, quercetin increased the levels of activating transcription factor (ATF)-6alpha, ATF-6beta and gastrin-releasing peptide-78 which indicated an increase in endoplasm reticulum stress, increased levels of the pro-apoptotic protein BH3 interacting-domain death antagonist, and decreased levels of anti-apoptotic proteins B-cell lymphoma (Bcl) 2 and Bcl-extra large which may have led to the decreases of DeltaPsim.	Quercetin	13-22	activating transcription factor 6 beta	Homo sapiens	93-102
29928342-7	2018	Furthermore, quercetin increased the levels of activating transcription factor (ATF)-6alpha, ATF-6beta and gastrin-releasing peptide-78 which indicated an increase in endoplasm reticulum stress, increased levels of the pro-apoptotic protein BH3 interacting-domain death antagonist, and decreased levels of anti-apoptotic proteins B-cell lymphoma (Bcl) 2 and Bcl-extra large which may have led to the decreases of DeltaPsim.	Quercetin	13-22	BCL2 apoptosis regulator	Homo sapiens	330-353
29928342-8	2018	Additionally, confocal microscopy suggested that quercetin was able to increase the expression levels of cytochrome c, apoptosis-inducing factor and endonuclease G, which are associated with apoptotic pathways.	Quercetin	49-58	cytochrome c, somatic	Homo sapiens	105-117
29620218-9	2018	Additionally, quercetin caused a marked inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and activated Akt serine/threonine protein kinase phosphorylation, which may result in attenuation of neuronal apoptosis.	Quercetin	14-23	AKT serine/threonine kinase 1	Rattus norvegicus	126-129
29708335-0	2018	Inhibitive Effects of Quercetin on Myeloperoxidase-Dependent Hypochlorous Acid Formation and Vascular Endothelial Injury.	Quercetin	22-31	myeloperoxidase	Homo sapiens	35-50
29708335-3	2018	In this study, we showed that quercetin inhibited MPO-mediated HOCl formation (75.0 +- 6.2% for 10 muM quercetin versus 100 +- 5.2% for control group, P &lt; 0.01) and cytotoxicity to endothelial cells in vitro, while this flavonoid was nontoxic to endothelial cell cultures ( P &gt; 0.05, all cases).	Quercetin	30-39	myeloperoxidase	Homo sapiens	50-53
29708335-3	2018	In this study, we showed that quercetin inhibited MPO-mediated HOCl formation (75.0 +- 6.2% for 10 muM quercetin versus 100 +- 5.2% for control group, P &lt; 0.01) and cytotoxicity to endothelial cells in vitro, while this flavonoid was nontoxic to endothelial cell cultures ( P &gt; 0.05, all cases).	Quercetin	103-112	myeloperoxidase	Homo sapiens	50-53
29861723-13	2018	Quercetin or alpha-lipoic acid pretreatment of AlCl3 exposed rats improved the protein carbonyl and reduced glutathione, glutathione reductase, and acetylcholine esterase activities in rat brains towards normal levels.	Quercetin	0-9	glutathione-disulfide reductase	Rattus norvegicus	121-142
29708335-4	2018	Moreover, quercetin inhibited HOCl generation by stimulated neutrophils (a rich source of MPO) and protected endothelial cells from neutrophils-induced injury.	Quercetin	10-19	myeloperoxidase	Homo sapiens	90-93
29708335-6	2018	Consistent with these in vitro data, quercetin attenuated lipopolysaccharide-induced endothelial dysfunction and increase of MPO activity in mouse aortas, while this flavonoid could protect against HOCl-mediated endothelial dysfunction in isolated aortas ( P &lt; 0.05).	Quercetin	37-46	myeloperoxidase	Mus musculus	125-128
29708335-7	2018	Therefore, it was proposed that quercetin attenuated endothelial injury in inflammatory vasculature via inhibition of vascular-bound MPO-mediated HOCl formation or scavenging of HOCl.	Quercetin	32-41	myeloperoxidase	Homo sapiens	133-136
29708335-8	2018	These data indicate that quercetin is a nontoxic inhibitor of MPO activity and MPO/neutrophils-induced cytotoxicity in endothelial cells and may be useful for targeting MPO-dependent vascular disease and inflammation.	Quercetin	25-34	myeloperoxidase	Homo sapiens	62-65
29708335-8	2018	These data indicate that quercetin is a nontoxic inhibitor of MPO activity and MPO/neutrophils-induced cytotoxicity in endothelial cells and may be useful for targeting MPO-dependent vascular disease and inflammation.	Quercetin	25-34	myeloperoxidase	Homo sapiens	79-82
29708335-8	2018	These data indicate that quercetin is a nontoxic inhibitor of MPO activity and MPO/neutrophils-induced cytotoxicity in endothelial cells and may be useful for targeting MPO-dependent vascular disease and inflammation.	Quercetin	25-34	myeloperoxidase	Homo sapiens	79-82
29693418-2	2018	Using a DMT-isolated micro vessel system, quercetin was found to exhibit a vasodilatory effect on basilar arteries contracted by potassium chloride (KCl), endothelin-1 (ET-1), and 5-hydroxytryptamine (5-HT).	Quercetin	42-51	endothelin 1	Homo sapiens	155-167
29477473-8	2018	The elevated levels of serum pro-inflammatory cytokines, IL-1beta and TNF-alpha, as well as PGE-2 and LTB-4 were decreased in non-diabetic and diabetic wounded rats with quercetin and LLLT while the lowered level of serum anti-inflammatory cytokine, IL-10, was increased.	Quercetin	170-179	interleukin 1 beta	Rattus norvegicus	57-65
29477473-8	2018	The elevated levels of serum pro-inflammatory cytokines, IL-1beta and TNF-alpha, as well as PGE-2 and LTB-4 were decreased in non-diabetic and diabetic wounded rats with quercetin and LLLT while the lowered level of serum anti-inflammatory cytokine, IL-10, was increased.	Quercetin	170-179	tumor necrosis factor	Rattus norvegicus	70-79
29477473-8	2018	The elevated levels of serum pro-inflammatory cytokines, IL-1beta and TNF-alpha, as well as PGE-2 and LTB-4 were decreased in non-diabetic and diabetic wounded rats with quercetin and LLLT while the lowered level of serum anti-inflammatory cytokine, IL-10, was increased.	Quercetin	170-179	interleukin 10	Rattus norvegicus	250-255
29809330-0	2018	[Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer s disease mice model.]	Quercetin	1-10	carbonic anhydrase 1	Mus musculus	39-42
29809330-3	2018	OBJECTIVE: To evaluate the effect of quercetin on the inflammatory response in the CA1 area of the hippocampus in a 3xTg-AD male and female mice model.	Quercetin	37-46	carbonic anhydrase 1	Mus musculus	83-86
29809330-7	2018	CONCLUSION: Our work suggests an anti-inflammatory effect of quercetin in the CA1 hippocampal region of aged triple transgenic Alzheimer"s disease mice.	Quercetin	61-70	carbonic anhydrase 1	Mus musculus	78-81
29394494-0	2018	Quercetin suppresses the chymotrypsin-like activity of proteasome via inhibition of MEK1/ERK1/2 signaling pathway in hepatocellular carcinoma HepG2 cells.	Quercetin	0-9	mitogen-activated protein kinase kinase 1	Homo sapiens	84-88
29394494-0	2018	Quercetin suppresses the chymotrypsin-like activity of proteasome via inhibition of MEK1/ERK1/2 signaling pathway in hepatocellular carcinoma HepG2 cells.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	89-95
29394494-8	2018	These results indicate that Que-induced suppression of MEK1/ERK1/2 signaling and subsequent reduction of proteasome beta subunits is responsible for its inhibitory impacts on proteasome activity.	Quercetin	28-31	mitogen-activated protein kinase kinase 1	Homo sapiens	55-59
29394494-8	2018	These results indicate that Que-induced suppression of MEK1/ERK1/2 signaling and subsequent reduction of proteasome beta subunits is responsible for its inhibitory impacts on proteasome activity.	Quercetin	28-31	mitogen-activated protein kinase 3	Homo sapiens	60-66
29887944-0	2018	Quercetin attenuates myocardial ischemia-reperfusion injury via downregulation of the HMGB1-TLR4-NF-kappaB signaling pathway.	Quercetin	0-9	high mobility group box 1	Rattus norvegicus	86-91
29887944-0	2018	Quercetin attenuates myocardial ischemia-reperfusion injury via downregulation of the HMGB1-TLR4-NF-kappaB signaling pathway.	Quercetin	0-9	toll-like receptor 4	Rattus norvegicus	92-96
29736333-6	2018	Our study showed that only Quercetin and 5-Hydroxyflavone were responsible for a significant down-regulation of the Kir6.1 activity, stabilising it in a closed conformation.	Quercetin	27-36	potassium inwardly-rectifying channel, subfamily J, member 8	Rattus norvegicus	116-122
29224051-0	2018	Quercetin Protects Yeast Saccharomyces cerevisiae pep4 Mutant from Oxidative and Apoptotic Stress and Extends Chronological Lifespan.	Quercetin	0-9	proteinase A	Saccharomyces cerevisiae S288C	50-54
29224051-5	2018	In contrast, quercetin pretreatment protected the pep4 mutant from oxidative and apoptotic stress-induced sensitivity by scavenging ROS and reducing apoptotic markers.	Quercetin	13-22	proteinase A	Saccharomyces cerevisiae S288C	50-54
29224051-6	2018	The percentage viability of quercetin-treated pep4  cells was more pronounced and increased stress resistance against oxidant, apoptotic, and heat stress during chronological aging.	Quercetin	28-37	proteinase A	Saccharomyces cerevisiae S288C	46-50
29224051-7	2018	From our experimental results, we concluded that quercetin protects yeast pep4 mutant cells from oxidative stress and apoptosis, thereby increasing viability during chronological aging.	Quercetin	49-58	proteinase A	Saccharomyces cerevisiae S288C	74-78
29044520-9	2018	Analysis of signaling molecules by Western blotting showed that in RCM-treated cells receiving initial pre-treatment with quercetin, followed by its removal, an increase in phosphorylation of Akt (Ser473), pSTAT3 (Tyr705), and FoxO3a (Thr32) as well as an induction of Pim-1 and decrease in PARP1 cleavage were observed.	Quercetin	122-131	AKT serine/threonine kinase 1	Homo sapiens	192-195
29044520-9	2018	Analysis of signaling molecules by Western blotting showed that in RCM-treated cells receiving initial pre-treatment with quercetin, followed by its removal, an increase in phosphorylation of Akt (Ser473), pSTAT3 (Tyr705), and FoxO3a (Thr32) as well as an induction of Pim-1 and decrease in PARP1 cleavage were observed.	Quercetin	122-131	forkhead box O3	Homo sapiens	227-233
29044520-9	2018	Analysis of signaling molecules by Western blotting showed that in RCM-treated cells receiving initial pre-treatment with quercetin, followed by its removal, an increase in phosphorylation of Akt (Ser473), pSTAT3 (Tyr705), and FoxO3a (Thr32) as well as an induction of Pim-1 and decrease in PARP1 cleavage were observed.	Quercetin	122-131	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	269-274
29044520-9	2018	Analysis of signaling molecules by Western blotting showed that in RCM-treated cells receiving initial pre-treatment with quercetin, followed by its removal, an increase in phosphorylation of Akt (Ser473), pSTAT3 (Tyr705), and FoxO3a (Thr32) as well as an induction of Pim-1 and decrease in PARP1 cleavage were observed.	Quercetin	122-131	poly(ADP-ribose) polymerase 1	Homo sapiens	291-296
29693418-2	2018	Using a DMT-isolated micro vessel system, quercetin was found to exhibit a vasodilatory effect on basilar arteries contracted by potassium chloride (KCl), endothelin-1 (ET-1), and 5-hydroxytryptamine (5-HT).	Quercetin	42-51	endothelin 1	Homo sapiens	169-173
29609590-9	2018	Quercetin and 10074-G5 were used to inhibit beta-catenin and MYC, respectively.	Quercetin	0-9	catenin beta 1	Homo sapiens	44-56
29701200-0	2018	Quercetin Inhibits the Migration and Invasion of HCCLM3 Cells by Suppressing the Expression of p-Akt1, Matrix Metalloproteinase (MMP) MMP-2, and MMP-9.	Quercetin	0-9	matrix metallopeptidase 2	Homo sapiens	134-139
29701200-0	2018	Quercetin Inhibits the Migration and Invasion of HCCLM3 Cells by Suppressing the Expression of p-Akt1, Matrix Metalloproteinase (MMP) MMP-2, and MMP-9.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	145-150
29701200-5	2018	Western blotting analysis was used to explore the expression of p-Akt1, MMP-2, and MMP-9 in quercetin-treated HCCLM3 cells.	Quercetin	92-101	matrix metallopeptidase 2	Homo sapiens	72-77
29701200-5	2018	Western blotting analysis was used to explore the expression of p-Akt1, MMP-2, and MMP-9 in quercetin-treated HCCLM3 cells.	Quercetin	92-101	matrix metallopeptidase 9	Homo sapiens	83-88
29701200-7	2018	Moreover, the protein levels of p-Akt1, MMP-2, and MMP-9 were down-regulated in quercetin-treated HCCLM3 cells, as detected by Western blotting.	Quercetin	80-89	matrix metallopeptidase 2	Homo sapiens	40-45
29701200-7	2018	Moreover, the protein levels of p-Akt1, MMP-2, and MMP-9 were down-regulated in quercetin-treated HCCLM3 cells, as detected by Western blotting.	Quercetin	80-89	matrix metallopeptidase 9	Homo sapiens	51-56
29701200-8	2018	CONCLUSIONS Our data show that quercetin attenuated cell migration and invasion by suppressing the protein levels of p-Akt1, MMP-2, and MMP-9 in HCCLM3 cells.	Quercetin	31-40	matrix metallopeptidase 2	Homo sapiens	125-130
29701200-8	2018	CONCLUSIONS Our data show that quercetin attenuated cell migration and invasion by suppressing the protein levels of p-Akt1, MMP-2, and MMP-9 in HCCLM3 cells.	Quercetin	31-40	matrix metallopeptidase 9	Homo sapiens	136-141
29611586-6	2018	Among the compounds identified in the hydrolyzed ULCE, quercetin exhibited the strongest inhibitory effect against TNF-alpha-induced cell adhesion capacity.	Quercetin	55-64	tumor necrosis factor	Mus musculus	115-124
29670213-5	2018	We further showed that quercetin attenuated AZT-induced up-regulation of Wnt5a, a key regulator of neuroinflammation.	Quercetin	23-32	Wnt family member 5A	Homo sapiens	73-78
29080823-10	2018	Depending on the incubation regimen, quercetin-biapigenin PCL-loaded nanoparticles or free compounds were more effective in protecting HepG2 cells against tert-butylhydroperoxide-induced toxicity.	Quercetin	37-46	PHD finger protein 1	Homo sapiens	58-61
29080823-11	2018	This is the first report of the encapsulation of a quercetin-biapigenin mixture in a polymeric matrix, specifically, in PCL, with synergic anti-oxidant and hepatoprotective effects.	Quercetin	51-60	PHD finger protein 1	Homo sapiens	120-123
29763367-11	2018	Nitric oxide, nitric oxide synthase, and inducible nitric oxide synthase levels in the hippocampus were significantly increased after hyperbaric oxygen exposure, but reversed by geranylgeranylacetone, while heat shock protein 70 inhibitor quercetin could inhibit this effect of geranylgeranylacetone.	Quercetin	239-248	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	207-228
29740251-0	2018	Inhibition of EGF expression and NF-kappaB activity by treatment with quercetin leads to suppression of angiogenesis in nasopharyngeal carcinoma.	Quercetin	70-79	epidermal growth factor	Homo sapiens	14-17
29740251-0	2018	Inhibition of EGF expression and NF-kappaB activity by treatment with quercetin leads to suppression of angiogenesis in nasopharyngeal carcinoma.	Quercetin	70-79	nuclear factor kappa B subunit 1	Homo sapiens	33-42
29740251-2	2018	The real-time RT-PCR and enzyme-linked immunosorbent assays (ELISA) were performed to analyze the expression levels of vascular endothelial growth factor (VEGF) in nasopharyngeal carcinoma cell lines prior to and after the quercetin treatment.	Quercetin	223-232	vascular endothelial growth factor A	Homo sapiens	155-159
29740251-4	2018	It was observed that quercetin treatment at a concentration of 10 mg/mL reduced the rate of NPC039 cell viability to 36% compared to control after 24 h. The expression of VEGF and activity of NF-kappaB was also markedly reduced.	Quercetin	21-30	vascular endothelial growth factor A	Homo sapiens	171-175
29740251-4	2018	It was observed that quercetin treatment at a concentration of 10 mg/mL reduced the rate of NPC039 cell viability to 36% compared to control after 24 h. The expression of VEGF and activity of NF-kappaB was also markedly reduced.	Quercetin	21-30	nuclear factor kappa B subunit 1	Homo sapiens	192-201
29563391-12	2018	This study reveals the neuroprotective effect of quercetin in an MCAO-induced animal model and demonstrates the regulation of caspase-3 and PARP expression by quercetin treatment.	Quercetin	159-168	caspase 3	Rattus norvegicus	126-135
29563391-12	2018	This study reveals the neuroprotective effect of quercetin in an MCAO-induced animal model and demonstrates the regulation of caspase-3 and PARP expression by quercetin treatment.	Quercetin	159-168	poly (ADP-ribose) polymerase 1	Rattus norvegicus	140-144
29563391-13	2018	These results suggest that quercetin exerts a neuroprotective effect through preventing the MCAO-induced activation of apoptotic pathways affecting caspase-3 and PARP expression.	Quercetin	27-36	caspase 3	Rattus norvegicus	148-157
29563391-13	2018	These results suggest that quercetin exerts a neuroprotective effect through preventing the MCAO-induced activation of apoptotic pathways affecting caspase-3 and PARP expression.	Quercetin	27-36	poly (ADP-ribose) polymerase 1	Rattus norvegicus	162-166
29720871-12	2018	Intracellular Ca2+ and ERK1/2 were involved in the signaling pathway of quercetin-induced insulin secretion.	Quercetin	72-81	mitogen-activated protein kinase 3	Mus musculus	23-29
29720871-13	2018	We also observed that quercetin could inhibit palmitic acid-induced cell apoptosis via suppressing the activation of caspase-3, -9, -12; increasing the ratio of Bcl-2/BAX and reversing the impaired mitochondrial membrane potential.	Quercetin	22-31	caspase 3	Mus musculus	117-130
29720871-13	2018	We also observed that quercetin could inhibit palmitic acid-induced cell apoptosis via suppressing the activation of caspase-3, -9, -12; increasing the ratio of Bcl-2/BAX and reversing the impaired mitochondrial membrane potential.	Quercetin	22-31	B cell leukemia/lymphoma 2	Mus musculus	161-166
29720871-13	2018	We also observed that quercetin could inhibit palmitic acid-induced cell apoptosis via suppressing the activation of caspase-3, -9, -12; increasing the ratio of Bcl-2/BAX and reversing the impaired mitochondrial membrane potential.	Quercetin	22-31	BCL2-associated X protein	Mus musculus	167-170
29736217-3	2018	The results showed that quercetin enrich diet could play an ameliorated pathology development of AD in APP/PS1 mice.	Quercetin	24-33	presenilin 1	Mus musculus	107-110
29681865-0	2018	Quercetin Increases MUC2 and MUC5AC Gene Expression and Secretion in Intestinal Goblet Cell-Like LS174T via PLC/PKCalpha/ERK1-2 Pathway.	Quercetin	0-9	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	20-24
29681865-0	2018	Quercetin Increases MUC2 and MUC5AC Gene Expression and Secretion in Intestinal Goblet Cell-Like LS174T via PLC/PKCalpha/ERK1-2 Pathway.	Quercetin	0-9	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	29-35
29681865-0	2018	Quercetin Increases MUC2 and MUC5AC Gene Expression and Secretion in Intestinal Goblet Cell-Like LS174T via PLC/PKCalpha/ERK1-2 Pathway.	Quercetin	0-9	protein kinase C alpha	Homo sapiens	112-120
29681865-0	2018	Quercetin Increases MUC2 and MUC5AC Gene Expression and Secretion in Intestinal Goblet Cell-Like LS174T via PLC/PKCalpha/ERK1-2 Pathway.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	121-127
29681865-5	2018	We found that quercetin increases intracellular Ca2+ levels and induces MUC2 and MUC5AC secretion in a Ca2+-dependent manner.	Quercetin	14-23	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	72-76
29681865-5	2018	We found that quercetin increases intracellular Ca2+ levels and induces MUC2 and MUC5AC secretion in a Ca2+-dependent manner.	Quercetin	14-23	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	81-87
29681865-8	2018	We also demonstrated that the induction of mucin gene expression by quercetin is not limited to goblet cells.	Quercetin	68-77	LOC100508689	Homo sapiens	43-48
29681865-9	2018	Indeed, quercetin induces mRNA levels of MUC2 and MUC5AC via PKCalpha/ERK1-2 pathway also in the human intestinal epithelial Caco-2 cells.	Quercetin	8-17	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	41-45
29681865-9	2018	Indeed, quercetin induces mRNA levels of MUC2 and MUC5AC via PKCalpha/ERK1-2 pathway also in the human intestinal epithelial Caco-2 cells.	Quercetin	8-17	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	50-56
29681865-9	2018	Indeed, quercetin induces mRNA levels of MUC2 and MUC5AC via PKCalpha/ERK1-2 pathway also in the human intestinal epithelial Caco-2 cells.	Quercetin	8-17	protein kinase C alpha	Homo sapiens	61-69
29681865-9	2018	Indeed, quercetin induces mRNA levels of MUC2 and MUC5AC via PKCalpha/ERK1-2 pathway also in the human intestinal epithelial Caco-2 cells.	Quercetin	8-17	mitogen-activated protein kinase 3	Homo sapiens	70-76
29681865-10	2018	These data highlight a novel mechanism thereby quercetin, regulating the secretory function of intestinal goblet cells and mucin levels in enterocytes may exert its protective effects on intestinal mucosal barrier.	Quercetin	47-56	LOC100508689	Homo sapiens	123-128
29609590-9	2018	Quercetin and 10074-G5 were used to inhibit beta-catenin and MYC, respectively.	Quercetin	0-9	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	61-64
28667374-14	2018	Furthermore, with the use of HSP70 analogy quercetin injection, it demonstrated that HSP70 is involved in mutant ataxin-3 reduction.	Quercetin	43-52	heat shock protein 1B	Mus musculus	29-34
28667374-14	2018	Furthermore, with the use of HSP70 analogy quercetin injection, it demonstrated that HSP70 is involved in mutant ataxin-3 reduction.	Quercetin	43-52	heat shock protein 1B	Mus musculus	85-90
28667374-14	2018	Furthermore, with the use of HSP70 analogy quercetin injection, it demonstrated that HSP70 is involved in mutant ataxin-3 reduction.	Quercetin	43-52	ataxin 3	Mus musculus	113-121
29411934-8	2018	The dextran-aldehyde-quercetin conjugate prepared at 40  C and 2 m HCl is shown to be cytotoxic to neuroblastoma cells (SH-SY5Y-IC50 = 123 microg mL-1 and BE(2)-C-IC50 = 380 microg mL-1 ) but shows no activity against nonmalignant MRC-5 cells at concentrations up to 400 microg mL-1 .	Quercetin	21-30	L1 cell adhesion molecule	Mus musculus	146-150
29380895-7	2018	Quercetin pretreatment resulted in a significant rise of muTBS when used at concentrations of 100 and 500 mug ml-1 .	Quercetin	0-9	interleukin 17F	Homo sapiens	110-114
29438776-0	2018	Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway.	Quercetin	0-9	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	97-102
29438776-0	2018	Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway.	Quercetin	0-9	X-box binding protein 1	Homo sapiens	103-107
29438776-3	2018	Quercetin intake decreased hepatic TG content by 39%, with a 1.5-fold increase in VLDL, and up-regulated spliced X-box binding protein 1 (XBP1s) expression compared with the HFD group.	Quercetin	0-9	X-box binding protein 1	Homo sapiens	113-136
29438776-4	2018	Thapsigargin or STF-083010 (an IRE1alpha endonuclease inhibitor) decreased VLDL content in a dose-dependent manner, partially counteracting the protective effects of quercetin, 4-PBA or APY-29 (an IRE1alpha endonuclease activator).	Quercetin	166-175	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	31-40
29438776-4	2018	Thapsigargin or STF-083010 (an IRE1alpha endonuclease inhibitor) decreased VLDL content in a dose-dependent manner, partially counteracting the protective effects of quercetin, 4-PBA or APY-29 (an IRE1alpha endonuclease activator).	Quercetin	166-175	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	197-206
29438776-6	2018	Moreover, quercetin increased co-localization of lysosomes with lipid droplets (LDs) accompanied by decreased p62 accumulation.	Quercetin	10-19	nucleoporin 62	Homo sapiens	110-113
29438776-7	2018	STF-083010 partially abolished the effect of quercetin on LDs autophagy in an mTOR-independent manner.	Quercetin	45-54	mechanistic target of rapamycin kinase	Homo sapiens	78-82
29438776-8	2018	Collectively, these findings demonstrate that hepatic VLDL assembly and lipophagy are the main targets of quercetin against NAFLD via the IRE1a/XBP1s pathway.	Quercetin	106-115	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	138-143
29438776-8	2018	Collectively, these findings demonstrate that hepatic VLDL assembly and lipophagy are the main targets of quercetin against NAFLD via the IRE1a/XBP1s pathway.	Quercetin	106-115	X-box binding protein 1	Homo sapiens	144-148
29606760-0	2018	Quercetin enhances stress resistance in Saccharomyces cerevisiae tel1 mutant cells to different stressors.	Quercetin	0-9	DNA-binding protein kinase TEL1	Saccharomyces cerevisiae S288C	65-69
29606760-3	2018	In the present study, we investigated the protective effects of quercetin on the sensitivity of yeast S. cerevisiae tel1  cells exposed to oxidative, apoptotic and DNA damaging stress and viability of tel1  cells during chronological aging.	Quercetin	64-73	DNA-binding protein kinase TEL1	Saccharomyces cerevisiae S288C	116-120
29606760-4	2018	Quercetin improved the stress resistance of tel1  cells when challenged with oxidants such as hydrogen peroxide (H2O2), menadine bisulphite (MBS) and tertiary butyl hydroperoxide (t-BHP) by scavenging reactive oxygen species (ROS).	Quercetin	0-9	DNA-binding protein kinase TEL1	Saccharomyces cerevisiae S288C	44-48
29606760-5	2018	Quercetin protected the tel1  cells from acetic acid-induced apoptotic cell death and sensitivity against hydroxyurea.	Quercetin	0-9	DNA-binding protein kinase TEL1	Saccharomyces cerevisiae S288C	24-28
29606760-6	2018	We found that quercetin attenuated ROS accumulation and apoptotic markers in tel1  cells and therefore an increase in cell viability during chronological aging.	Quercetin	14-23	DNA-binding protein kinase TEL1	Saccharomyces cerevisiae S288C	77-81
29411934-8	2018	The dextran-aldehyde-quercetin conjugate prepared at 40  C and 2 m HCl is shown to be cytotoxic to neuroblastoma cells (SH-SY5Y-IC50 = 123 microg mL-1 and BE(2)-C-IC50 = 380 microg mL-1 ) but shows no activity against nonmalignant MRC-5 cells at concentrations up to 400 microg mL-1 .	Quercetin	21-30	L1 cell adhesion molecule	Mus musculus	181-185
29411934-8	2018	The dextran-aldehyde-quercetin conjugate prepared at 40  C and 2 m HCl is shown to be cytotoxic to neuroblastoma cells (SH-SY5Y-IC50 = 123 microg mL-1 and BE(2)-C-IC50 = 380 microg mL-1 ) but shows no activity against nonmalignant MRC-5 cells at concentrations up to 400 microg mL-1 .	Quercetin	21-30	L1 cell adhesion molecule	Mus musculus	181-185
29747752-8	2018	Further research revealed that reduction of FZD7 by RNA interference (siFZD7) enhanced the sensitivity to chemotherapeutic drugs, increased the cellular accumulation of Rh123 and ADR, and induced inhibitory effects on the expression of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin, similar to quercetin.	Quercetin	291-300	frizzled class receptor 7	Homo sapiens	72-76
29720826-2	2018	Objective: In this study, it was aimed to investigate the effects of hesperidin (HP) and quercetin, which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) levels in rats with streptozotocin (STZ)-induced diabetes.	Quercetin	89-98	tumor necrosis factor	Rattus norvegicus	181-208
29720826-2	2018	Objective: In this study, it was aimed to investigate the effects of hesperidin (HP) and quercetin, which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) levels in rats with streptozotocin (STZ)-induced diabetes.	Quercetin	89-98	tumor necrosis factor	Rattus norvegicus	210-219
29720826-2	2018	Objective: In this study, it was aimed to investigate the effects of hesperidin (HP) and quercetin, which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) levels in rats with streptozotocin (STZ)-induced diabetes.	Quercetin	89-98	interleukin 6	Rattus norvegicus	226-239
29720826-2	2018	Objective: In this study, it was aimed to investigate the effects of hesperidin (HP) and quercetin, which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) levels in rats with streptozotocin (STZ)-induced diabetes.	Quercetin	89-98	interleukin 6	Rattus norvegicus	241-245
29537893-4	2018	Now we take further our research by evaluating the effect of berberine, quercetin, tyrosol, and ferulic acid on the mTOR/S6K1/4E-BP1 signaling, along with the existence of any synergistic effect between the following associations: berberine + tyrosol, tyrosol + ferulic acid, ferulic acid + quercetin.	Quercetin	72-81	mechanistic target of rapamycin kinase	Homo sapiens	116-120
29747752-0	2018	Reversal effect of quercetin on multidrug resistance via FZD7/beta-catenin pathway in hepatocellular carcinoma cells.	Quercetin	19-28	frizzled class receptor 7	Homo sapiens	57-61
29747752-0	2018	Reversal effect of quercetin on multidrug resistance via FZD7/beta-catenin pathway in hepatocellular carcinoma cells.	Quercetin	19-28	catenin beta 1	Homo sapiens	62-74
29747752-8	2018	Further research revealed that reduction of FZD7 by RNA interference (siFZD7) enhanced the sensitivity to chemotherapeutic drugs, increased the cellular accumulation of Rh123 and ADR, and induced inhibitory effects on the expression of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin, similar to quercetin.	Quercetin	291-300	ATP binding cassette subfamily B member 1	Homo sapiens	242-247
29747752-7	2018	Moreover, the suppression of ABCB1, ABCC1 and ABCC2 by quercetin was dependent on the FZD7 through the Wnt/beta-catenin pathway.	Quercetin	55-64	ATP binding cassette subfamily B member 1	Homo sapiens	29-34
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	35-44	frizzled class receptor 7	Homo sapiens	84-88
29747752-7	2018	Moreover, the suppression of ABCB1, ABCC1 and ABCC2 by quercetin was dependent on the FZD7 through the Wnt/beta-catenin pathway.	Quercetin	55-64	ATP binding cassette subfamily C member 1	Homo sapiens	36-41
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	35-44	ATP binding cassette subfamily B member 1	Homo sapiens	90-95
29747752-7	2018	Moreover, the suppression of ABCB1, ABCC1 and ABCC2 by quercetin was dependent on the FZD7 through the Wnt/beta-catenin pathway.	Quercetin	55-64	ATP binding cassette subfamily C member 2	Homo sapiens	46-51
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	35-44	ATP binding cassette subfamily C member 1	Homo sapiens	97-102
29747752-7	2018	Moreover, the suppression of ABCB1, ABCC1 and ABCC2 by quercetin was dependent on the FZD7 through the Wnt/beta-catenin pathway.	Quercetin	55-64	frizzled class receptor 7	Homo sapiens	86-90
29747752-7	2018	Moreover, the suppression of ABCB1, ABCC1 and ABCC2 by quercetin was dependent on the FZD7 through the Wnt/beta-catenin pathway.	Quercetin	55-64	catenin beta 1	Homo sapiens	107-119
29747752-8	2018	Further research revealed that reduction of FZD7 by RNA interference (siFZD7) enhanced the sensitivity to chemotherapeutic drugs, increased the cellular accumulation of Rh123 and ADR, and induced inhibitory effects on the expression of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin, similar to quercetin.	Quercetin	291-300	frizzled class receptor 7	Homo sapiens	44-48
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	35-44	ATP binding cassette subfamily C member 2	Homo sapiens	104-109
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	35-44	catenin beta 1	Homo sapiens	114-126
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	172-181	frizzled class receptor 7	Homo sapiens	84-88
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	172-181	ATP binding cassette subfamily B member 1	Homo sapiens	90-95
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	172-181	ATP binding cassette subfamily C member 1	Homo sapiens	97-102
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	172-181	ATP binding cassette subfamily C member 2	Homo sapiens	104-109
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	172-181	catenin beta 1	Homo sapiens	114-126
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	172-181	frizzled class receptor 7	Homo sapiens	84-88
29331686-3	2018	The aim of the current study was pilot analysis of quercetin tolerability and its impact on somatic cells count (SCC) after multiple intramammary treatment on dairy cows with clinical mastitis.	Quercetin	51-60	SCC	Bos taurus	113-116
29331686-9	2018	The presented results allowed the confirmation of the significant influence of quercetin on the reduction of SCC in mastitis in dairy cows after 8days of therapy.	Quercetin	79-88	SCC	Bos taurus	109-112
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	172-181	ATP binding cassette subfamily B member 1	Homo sapiens	90-95
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	172-181	ATP binding cassette subfamily C member 1	Homo sapiens	97-102
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	172-181	ATP binding cassette subfamily C member 2	Homo sapiens	104-109
29747752-10	2018	Interesting, it was confirmed that quercetin could inhibit the expression levels of FZD7, ABCB1, ABCC1, ABCC2 and beta-catenin in BEL-7402 cells; furthermore, treatment by quercetin combined with siFZD7 in BEL/5-FU cells, the expressions of these genes were effectively decreased in comparison to quercetin combined with siRNA negative control (sncRNA).	Quercetin	172-181	catenin beta 1	Homo sapiens	114-126
29747752-11	2018	CONCLUSION: Overall, these data suggested the effectiveness of using quercetin, at least in part, via inhibiting FZD7 to combat chemoresistance and showed that quercetin could be developed into an efficient natural sensitizer for resistant human hepatocellular carcinoma.	Quercetin	69-78	frizzled class receptor 7	Homo sapiens	113-117
29747752-11	2018	CONCLUSION: Overall, these data suggested the effectiveness of using quercetin, at least in part, via inhibiting FZD7 to combat chemoresistance and showed that quercetin could be developed into an efficient natural sensitizer for resistant human hepatocellular carcinoma.	Quercetin	160-169	frizzled class receptor 7	Homo sapiens	113-117
29535328-0	2018	Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken.	Quercetin	7-16	phosphoglycolate phosphatase	Gallus gallus	48-52
29425740-7	2018	However, apigenin and (+-) equol did not inhibit human HSD11B2 at concentrations as high as 100 muM, while genistein and quercetin inhibited human HSD11B2 by 60% and 50% at 100 muM, respectively.	Quercetin	121-130	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	147-154
29425820-0	2018	Quercetin restrains TGF-beta1-induced epithelial-mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression.	Quercetin	0-9	transforming growth factor beta 1	Homo sapiens	20-29
29425820-0	2018	Quercetin restrains TGF-beta1-induced epithelial-mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression.	Quercetin	0-9	twist family bHLH transcription factor 1	Homo sapiens	86-92
29425820-0	2018	Quercetin restrains TGF-beta1-induced epithelial-mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression.	Quercetin	0-9	cadherin 1	Homo sapiens	108-118
29425820-5	2018	In this study, we identified a unique function of quercetin in inhibiting the EMT process induced by TGF-beta1.	Quercetin	50-59	transforming growth factor beta 1	Homo sapiens	101-110
29425820-6	2018	In particular, quercetin rescued the morphological changes and EMT-like phenotypes in TGF-beta1-activated SW480 cells, and this inhibition of TGF-beta1-induced EMT was mediated via the suppression of Twist1 expression.	Quercetin	15-24	transforming growth factor beta 1	Homo sapiens	86-95
29425820-6	2018	In particular, quercetin rescued the morphological changes and EMT-like phenotypes in TGF-beta1-activated SW480 cells, and this inhibition of TGF-beta1-induced EMT was mediated via the suppression of Twist1 expression.	Quercetin	15-24	transforming growth factor beta 1	Homo sapiens	142-151
29425820-6	2018	In particular, quercetin rescued the morphological changes and EMT-like phenotypes in TGF-beta1-activated SW480 cells, and this inhibition of TGF-beta1-induced EMT was mediated via the suppression of Twist1 expression.	Quercetin	15-24	twist family bHLH transcription factor 1	Homo sapiens	200-206
29425820-7	2018	In addition, quercetin strongly suppressed TGF-beta1-induced invasion of SW480 cells.	Quercetin	13-22	transforming growth factor beta 1	Homo sapiens	43-52
29615901-3	2018	Quercetin is a naturally occurring flavonol with established AMPK-stimulating activity.	Quercetin	0-9	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	61-65
29736392-0	2018	Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway.	Quercetin	0-9	estrogen receptor 1 (alpha)	Mus musculus	82-99
29332828-9	2018	Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references.	Quercetin	106-115	ribonuclease P/MRP subunit p14	Homo sapiens	33-36
29332828-9	2018	Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references.	Quercetin	106-115	interleukin 23 subunit alpha	Homo sapiens	38-41
29332828-9	2018	Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references.	Quercetin	106-115	H3 histone pseudogene 16	Homo sapiens	43-46
29332828-9	2018	Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references.	Quercetin	106-115	centromere protein V	Homo sapiens	52-55
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	bone morphogenetic protein 2	Mus musculus	256-284
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	bone morphogenetic protein 2	Mus musculus	286-290
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	SMAD family member 1	Mus musculus	293-298
29736392-6	2018	Results: The CCK-8 and ALP assays and ARS staining showed that quercetin significantly enhanced BMSC proliferation, ALP activity, and extracellular matrix production and mineralization, respectively.	Quercetin	63-72	secreted Ly6/Plaur domain containing 1	Mus musculus	38-41
29535328-2	2018	Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear.	Quercetin	0-9	phosphoglycolate phosphatase	Gallus gallus	38-42
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	Sp7 transcription factor 7	Mus musculus	51-58
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	Sp7 transcription factor 7	Mus musculus	60-63
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	SMAD family member 4	Mus musculus	300-305
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	runt related transcription factor 2	Mus musculus	307-312
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	runt related transcription factor 2	Mus musculus	66-101
29535328-2	2018	Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear.	Quercetin	0-9	phosphoglycolate phosphatase	Gallus gallus	79-83
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	runt related transcription factor 2	Mus musculus	103-108
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	Sp7 transcription factor 7	Mus musculus	314-317
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	secreted phosphoprotein 1	Mus musculus	323-326
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	SMAD family member 1	Mus musculus	342-347
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	secreted phosphoprotein 1	Mus musculus	115-126
29736392-7	2018	The qPCR results indicated that quercetin promoted osterix (OSX), runt-related transcription factor 2 (RUNX2), and osteopontin (OPN) transcription in the presence of osteoinduction medium, and the western blotting results indicated that quercetin enhanced bone morphogenetic protein 2 (BMP2), Smad1, Smad4, RUNX2, OSX, and OPN expression and Smad1 phosphorylation.	Quercetin	32-41	secreted phosphoprotein 1	Mus musculus	128-131
29736392-8	2018	Treatment with the ER inhibitor ICI182780 blocked the effects of quercetin.	Quercetin	65-74	estrogen receptor 1 (alpha)	Mus musculus	19-21
29535328-3	2018	Herein, study reports role of quercetin in modulation of P-gp expression and subsequent effects on the pharmacokinetics of enrofloxacin in broilers.	Quercetin	30-39	phosphoglycolate phosphatase	Gallus gallus	57-61
29736392-10	2018	Quercetin enhances BMP signaling pathway activation and upregulates the expression of downstream genes, such as OSX, RUNX2, and OPN, via the ER.	Quercetin	0-9	bone morphogenetic protein 2	Mus musculus	19-22
29736392-10	2018	Quercetin enhances BMP signaling pathway activation and upregulates the expression of downstream genes, such as OSX, RUNX2, and OPN, via the ER.	Quercetin	0-9	Sp7 transcription factor 7	Mus musculus	112-115
29535328-4	2018	Results show that P-gp expression was increased in a dose-dependent manner following exposure to quercetin in Caco-2 cells and tissues of chicken.	Quercetin	97-106	phosphoglycolate phosphatase	Homo sapiens	18-22
29736392-10	2018	Quercetin enhances BMP signaling pathway activation and upregulates the expression of downstream genes, such as OSX, RUNX2, and OPN, via the ER.	Quercetin	0-9	runt related transcription factor 2	Mus musculus	117-122
29736392-10	2018	Quercetin enhances BMP signaling pathway activation and upregulates the expression of downstream genes, such as OSX, RUNX2, and OPN, via the ER.	Quercetin	0-9	secreted phosphoprotein 1	Mus musculus	128-131
29535328-5	2018	Absorption rate constant and apparent permeability coefficient of rhodamine 123 were decreased, reflecting efflux function of P-gp in chicken intestine increased by quercetin.	Quercetin	165-174	phosphoglycolate phosphatase	Gallus gallus	126-130
29736392-10	2018	Quercetin enhances BMP signaling pathway activation and upregulates the expression of downstream genes, such as OSX, RUNX2, and OPN, via the ER.	Quercetin	0-9	estrogen receptor 1 (alpha)	Mus musculus	141-143
29535328-7	2018	Molecular docking shows quercetin can form favorable interactions with binding pocket of chicken xenobiotic receptor (CXR).	Quercetin	24-33	nuclear receptor subfamily 1 group I member 3	Gallus gallus	118-121
29535328-8	2018	Results provide convincing evidence that quercetin induced P-gp expression in tissues by possible interaction with CXR, and consequently reducing bioavailability of orally administered enrofloxacin through restricting its intestinal absorption and liver/kidney clearance in broilers.	Quercetin	41-50	phosphoglycolate phosphatase	Gallus gallus	59-63
29535328-8	2018	Results provide convincing evidence that quercetin induced P-gp expression in tissues by possible interaction with CXR, and consequently reducing bioavailability of orally administered enrofloxacin through restricting its intestinal absorption and liver/kidney clearance in broilers.	Quercetin	41-50	nuclear receptor subfamily 1 group I member 3	Gallus gallus	115-118
29480020-7	2018	Treatment with quercetin in the pristane-induced LN mice model was nephroprotective, decreasing proteinuria levels and significantly lowering tissue expression of IL-6, TNF-alpha, TGF-beta1, Bax and TBARS.	Quercetin	15-24	interleukin 6	Mus musculus	163-167
29425960-0	2018	Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension.	Quercetin	0-9	matrix metallopeptidase 2	Rattus norvegicus	36-62
29469041-6	2018	RESULTS: Quercetin decreased the intracellular lipids, LD size and the levels of intracellular-TG through the down-regulation of SREBP-1c, PPARgamma and ACAT1 increasing PPARalpha.	Quercetin	9-18	sterol regulatory element binding transcription factor 1	Homo sapiens	129-137
29469041-6	2018	RESULTS: Quercetin decreased the intracellular lipids, LD size and the levels of intracellular-TG through the down-regulation of SREBP-1c, PPARgamma and ACAT1 increasing PPARalpha.	Quercetin	9-18	peroxisome proliferator activated receptor gamma	Homo sapiens	139-148
29469041-6	2018	RESULTS: Quercetin decreased the intracellular lipids, LD size and the levels of intracellular-TG through the down-regulation of SREBP-1c, PPARgamma and ACAT1 increasing PPARalpha.	Quercetin	9-18	acetyl-CoA acetyltransferase 1	Homo sapiens	153-158
29469041-6	2018	RESULTS: Quercetin decreased the intracellular lipids, LD size and the levels of intracellular-TG through the down-regulation of SREBP-1c, PPARgamma and ACAT1 increasing PPARalpha.	Quercetin	9-18	peroxisome proliferator activated receptor alpha	Homo sapiens	170-179
29425960-2	2018	As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduce increased MMP-2 activity by decreasing oxidative stress in aortas of hypertensive rats and then ameliorate hypertension-induced vascular remodeling.	Quercetin	3-12	matrix metallopeptidase 2	Rattus norvegicus	137-142
29480020-7	2018	Treatment with quercetin in the pristane-induced LN mice model was nephroprotective, decreasing proteinuria levels and significantly lowering tissue expression of IL-6, TNF-alpha, TGF-beta1, Bax and TBARS.	Quercetin	15-24	tumor necrosis factor	Mus musculus	169-178
29425960-2	2018	As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduce increased MMP-2 activity by decreasing oxidative stress in aortas of hypertensive rats and then ameliorate hypertension-induced vascular remodeling.	Quercetin	105-114	matrix metallopeptidase 2	Rattus norvegicus	137-142
29425960-13	2018	CONCLUSIONS: Quercetin reduces hypertension-induced vascular remodeling, oxidative stress and MMP-2 activity in aortas.	Quercetin	13-22	matrix metallopeptidase 2	Rattus norvegicus	94-99
29480020-7	2018	Treatment with quercetin in the pristane-induced LN mice model was nephroprotective, decreasing proteinuria levels and significantly lowering tissue expression of IL-6, TNF-alpha, TGF-beta1, Bax and TBARS.	Quercetin	15-24	transforming growth factor, beta 1	Mus musculus	180-189
29480020-7	2018	Treatment with quercetin in the pristane-induced LN mice model was nephroprotective, decreasing proteinuria levels and significantly lowering tissue expression of IL-6, TNF-alpha, TGF-beta1, Bax and TBARS.	Quercetin	15-24	BCL2-associated X protein	Mus musculus	191-194
29480020-8	2018	Simultaneously, quercetin significantly increased CAT and SOD1 expressions in these mice.	Quercetin	16-25	catalase	Mus musculus	50-53
29480020-8	2018	Simultaneously, quercetin significantly increased CAT and SOD1 expressions in these mice.	Quercetin	16-25	superoxide dismutase 1, soluble	Mus musculus	58-62
29355544-0	2018	Quercetin suppresses breast cancer stem cells (CD44+/CD24-) by inhibiting the PI3K/Akt/mTOR-signaling pathway.	Quercetin	0-9	CD44 molecule (Indian blood group)	Homo sapiens	47-51
29124510-9	2018	It was observed that inhibition of Hsp27 synthesis by Quercetin abolished LPS-induced renoprotective effects.	Quercetin	54-63	heat shock protein 1	Mus musculus	35-40
29124510-9	2018	It was observed that inhibition of Hsp27 synthesis by Quercetin abolished LPS-induced renoprotective effects.	Quercetin	54-63	toll-like receptor 4	Mus musculus	74-77
28808887-0	2018	Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats.	Quercetin	19-28	sirtuin 1	Rattus norvegicus	101-106
29108086-8	2018	Quercetin showed a high ORAC value (2.70+-0.12 ORAC Units), according to a low BDE (74.54 Kcal/mol) and IP (174.44 Kcal/mol) values.	Quercetin	0-9	homeobox D13	Homo sapiens	79-82
29197723-10	2018	The protective analgesic and anti-inflammatory mechanisms of quercetin included the inhibition of TiO2-induced neutrophil and macrophage recruitment, proteoglycan degradation, oxidative stress, cytokine production (TNF-alpha, IL-1beta, IL-6, and IL-10), COX-2 mRNA expression, and bone resorption as well as activation of Nrf2/HO-1 signaling pathway.	Quercetin	61-70	tumor necrosis factor	Mus musculus	215-224
29197723-10	2018	The protective analgesic and anti-inflammatory mechanisms of quercetin included the inhibition of TiO2-induced neutrophil and macrophage recruitment, proteoglycan degradation, oxidative stress, cytokine production (TNF-alpha, IL-1beta, IL-6, and IL-10), COX-2 mRNA expression, and bone resorption as well as activation of Nrf2/HO-1 signaling pathway.	Quercetin	61-70	interleukin 1 beta	Mus musculus	226-234
29197723-10	2018	The protective analgesic and anti-inflammatory mechanisms of quercetin included the inhibition of TiO2-induced neutrophil and macrophage recruitment, proteoglycan degradation, oxidative stress, cytokine production (TNF-alpha, IL-1beta, IL-6, and IL-10), COX-2 mRNA expression, and bone resorption as well as activation of Nrf2/HO-1 signaling pathway.	Quercetin	61-70	interleukin 6	Mus musculus	236-240
29197723-10	2018	The protective analgesic and anti-inflammatory mechanisms of quercetin included the inhibition of TiO2-induced neutrophil and macrophage recruitment, proteoglycan degradation, oxidative stress, cytokine production (TNF-alpha, IL-1beta, IL-6, and IL-10), COX-2 mRNA expression, and bone resorption as well as activation of Nrf2/HO-1 signaling pathway.	Quercetin	61-70	interleukin 10	Mus musculus	246-251
29197723-10	2018	The protective analgesic and anti-inflammatory mechanisms of quercetin included the inhibition of TiO2-induced neutrophil and macrophage recruitment, proteoglycan degradation, oxidative stress, cytokine production (TNF-alpha, IL-1beta, IL-6, and IL-10), COX-2 mRNA expression, and bone resorption as well as activation of Nrf2/HO-1 signaling pathway.	Quercetin	61-70	cytochrome c oxidase II, mitochondrial	Mus musculus	254-259
29197723-10	2018	The protective analgesic and anti-inflammatory mechanisms of quercetin included the inhibition of TiO2-induced neutrophil and macrophage recruitment, proteoglycan degradation, oxidative stress, cytokine production (TNF-alpha, IL-1beta, IL-6, and IL-10), COX-2 mRNA expression, and bone resorption as well as activation of Nrf2/HO-1 signaling pathway.	Quercetin	61-70	nuclear factor, erythroid derived 2, like 2	Mus musculus	322-326
29355544-0	2018	Quercetin suppresses breast cancer stem cells (CD44+/CD24-) by inhibiting the PI3K/Akt/mTOR-signaling pathway.	Quercetin	0-9	CD24 molecule	Homo sapiens	53-57
29355544-0	2018	Quercetin suppresses breast cancer stem cells (CD44+/CD24-) by inhibiting the PI3K/Akt/mTOR-signaling pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	83-86
29355544-0	2018	Quercetin suppresses breast cancer stem cells (CD44+/CD24-) by inhibiting the PI3K/Akt/mTOR-signaling pathway.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	87-91
29355544-4	2018	KEY FINDINGS: Our results indicated that cell viability, clone formation, mammosphere generation, and nude mice tumor metastasis were inhibited in the CD44+/CD24- population and that MCF-7 cells exhibited G1-phase arrest after quercetin treatment.	Quercetin	227-236	CD44 antigen	Mus musculus	151-155
29355544-5	2018	Additionally, CyclinD1 and B cell lymphoma-2 expression were suppressed and Bcl-2-like protein-4 expression was enhanced after quercetin treatment.	Quercetin	127-136	cyclin D1	Homo sapiens	14-22
29355544-5	2018	Additionally, CyclinD1 and B cell lymphoma-2 expression were suppressed and Bcl-2-like protein-4 expression was enhanced after quercetin treatment.	Quercetin	127-136	BCL2 associated X, apoptosis regulator	Homo sapiens	76-96
29355544-7	2018	Our findings suggested that quercetin treatment promoted weaker malignant activity associated with CSCs relative to that observed in normal cancer cells through its inhibition of the PI3K/Akt/mTOR-signaling pathway.	Quercetin	28-37	AKT serine/threonine kinase 1	Homo sapiens	188-191
29355544-7	2018	Our findings suggested that quercetin treatment promoted weaker malignant activity associated with CSCs relative to that observed in normal cancer cells through its inhibition of the PI3K/Akt/mTOR-signaling pathway.	Quercetin	28-37	mechanistic target of rapamycin kinase	Homo sapiens	192-196
29681968-0	2018	Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF.	Quercetin	0-9	nerve growth factor	Rattus norvegicus	26-29
29266790-0	2018	Quercetin Attenuates Ethanol-Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II-L-Type Calcium Channel.	Quercetin	0-9	angiotensinogen	Rattus norvegicus	89-103
29266790-3	2018	This study aims to explore whether quercetin attenuates ethanol-induced iron uptake and myocardial injury by regulating angiotensin II-L-type voltage-dependent Ca2+ channel (Ang II-LTCC).	Quercetin	35-44	angiotensinogen	Rattus norvegicus	120-134
29266790-3	2018	This study aims to explore whether quercetin attenuates ethanol-induced iron uptake and myocardial injury by regulating angiotensin II-L-type voltage-dependent Ca2+ channel (Ang II-LTCC).	Quercetin	35-44	angiotensinogen	Rattus norvegicus	174-185
29266790-5	2018	Quercetin alleviated ethanol-induced histopathological changes, creatine kinase isoenzyme release, Ang II secretion, ROS generation, total cardiac iron, and labile iron level.	Quercetin	0-9	angiotensinogen	Rattus norvegicus	99-105
29266790-10	2018	CONCLUSION: Alcohol-induced cardiac injury is associated with excessive NTBI uptake mediated by Ang II-LTCC activation which may be mediated by quercetin against ethanol cardiotoxicity.	Quercetin	144-153	angiotensinogen	Rattus norvegicus	96-102
29681968-0	2018	Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF.	Quercetin	0-9	nerve growth factor	Rattus norvegicus	123-126
29681968-7	2018	By using LC-MS/MS analysis, one of the NGF binding fractions was enriched, which was further identified as quercetin, a major flavonoid in Ginkgo Folium.	Quercetin	107-116	nerve growth factor	Rattus norvegicus	39-42
29681968-8	2018	Quercetin, similar to Ginkgo Folium extract, could enhance the effect of NGF in cultured PC 12 cells, including potentiation of neurite outgrowth and phosphorylation of Erk-1/2.	Quercetin	0-9	nerve growth factor	Rattus norvegicus	73-76
29681968-8	2018	Quercetin, similar to Ginkgo Folium extract, could enhance the effect of NGF in cultured PC 12 cells, including potentiation of neurite outgrowth and phosphorylation of Erk-1/2.	Quercetin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	169-176
29472583-8	2018	Treatment with quercetin and green tea induced conversion of LC3-I to LC3-II as well as activation of autophagy proteins, suggesting that quercetin and green tea initiate the autophagic progression.	Quercetin	15-24	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	158-161
29472583-5	2018	Quercetin and green tea reduced tumor growth in HL-60 xenografts accompanied by decreased expression of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1 and increased expression of BAX, a pro-apoptotic protein.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	129-134
29472583-8	2018	Treatment with quercetin and green tea induced conversion of LC3-I to LC3-II as well as activation of autophagy proteins, suggesting that quercetin and green tea initiate the autophagic progression.	Quercetin	138-147	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	35-38
29472583-5	2018	Quercetin and green tea reduced tumor growth in HL-60 xenografts accompanied by decreased expression of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1 and increased expression of BAX, a pro-apoptotic protein.	Quercetin	0-9	BCL2 like 1	Homo sapiens	136-142
29472583-5	2018	Quercetin and green tea reduced tumor growth in HL-60 xenografts accompanied by decreased expression of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1 and increased expression of BAX, a pro-apoptotic protein.	Quercetin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	147-152
29497376-10	2018	In vitro, studies further revealed that quercetin efficiently inhibited macrophages activation and M1 polarization, as well as decreased the mRNA expression of M1 macrophage markers such as TNF-alpha, IL-1beta, IL-6, and nitric oxide synthase 2.	Quercetin	40-49	tumor necrosis factor	Mus musculus	190-199
29472583-5	2018	Quercetin and green tea reduced tumor growth in HL-60 xenografts accompanied by decreased expression of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1 and increased expression of BAX, a pro-apoptotic protein.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	181-184
29472583-6	2018	Moreover, caspase-3 was activated to a greater extent after quercetin and green tea treatment.	Quercetin	60-69	caspase 3	Homo sapiens	10-19
29618945-5	2018	We herein describe in vitro and in vivo effects of fifteen Nrf2-interacting natural compounds (tocotrienols, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, silybin, phenethyl isothiocyanate, sulforaphane, triptolide, allicin, berberine, piperlongumine, fisetin, and phloretin) on cellular senescence and discuss their use in adjuvant cancer therapy.	Quercetin	145-154	NFE2 like bZIP transcription factor 2	Homo sapiens	59-63
29339254-5	2018	Consistently, (4b) was the most potent inhibitor when tested against Soybean 15-LOX (IC50 = 3.84 muM) excelling quercetin as standard inhibitor by 1.8 folds.	Quercetin	112-121	arachidonate 15-lipoxygenase	Homo sapiens	77-83
29497376-10	2018	In vitro, studies further revealed that quercetin efficiently inhibited macrophages activation and M1 polarization, as well as decreased the mRNA expression of M1 macrophage markers such as TNF-alpha, IL-1beta, IL-6, and nitric oxide synthase 2.	Quercetin	40-49	interleukin 1 beta	Mus musculus	201-209
29497376-10	2018	In vitro, studies further revealed that quercetin efficiently inhibited macrophages activation and M1 polarization, as well as decreased the mRNA expression of M1 macrophage markers such as TNF-alpha, IL-1beta, IL-6, and nitric oxide synthase 2.	Quercetin	40-49	interleukin 6	Mus musculus	211-215
29497376-11	2018	Mechanistically, the inhibition of M1 macrophages by quercetin was associated with the decreased levels of Notch1 expression on macrophages both in vivo and in vitro.	Quercetin	53-62	notch 1	Mus musculus	107-113
29497376-12	2018	Taken together, our data indicated that quercetin attenuated CCl4-induced liver inflammation and fibrosis in mice through inhibiting macrophages infiltration and modulating M1 macrophages polarization via targeting Notch1 pathway.	Quercetin	40-49	notch 1	Mus musculus	215-221
29415436-6	2018	The sensing performance of the prepared NAA platforms was examined by real-time screening of binding reactions between human serum albumin (HSA)-modified NAA (i.e., sensing element) and quercetin (i.e., analyte).	Quercetin	186-195	albumin	Homo sapiens	125-138
29207037-3	2018	It was identified that quercetin and galangin markedly reduced the production of nitric oxide (NO), inducible NO synthase and interleukin-6, and the nuclear translocation of nuclear factor-kappaB (NF-kappaB).	Quercetin	23-32	nitric oxide synthase 2, inducible	Mus musculus	100-121
29435775-5	2018	Angiotensin II (Ang II)-induced primary cardiomyocytes were cultured with quercetin treatment or not for 48 h. Echocardiography, real-time RT-PCR, histology, immunofluorescence, and Western blotting were conducted.	Quercetin	74-83	angiotensinogen	Rattus norvegicus	0-14
29435775-8	2018	In addition, quercetin also significantly reduced the Ang II-induced hypertrophic surface area and atrial natriuretic factor (ANF) mRNA level in primary cardiomyocytes.	Quercetin	13-22	angiotensinogen	Rattus norvegicus	54-60
29435775-8	2018	In addition, quercetin also significantly reduced the Ang II-induced hypertrophic surface area and atrial natriuretic factor (ANF) mRNA level in primary cardiomyocytes.	Quercetin	13-22	natriuretic peptide A	Rattus norvegicus	99-124
29435775-8	2018	In addition, quercetin also significantly reduced the Ang II-induced hypertrophic surface area and atrial natriuretic factor (ANF) mRNA level in primary cardiomyocytes.	Quercetin	13-22	natriuretic peptide A	Rattus norvegicus	126-129
29435775-10	2018	Quercetin also decreased the levels of proteasome subunit beta type (PSMB) 1, PSMB2, and PSMB5 of the 20S proteasome as well as the levels of proteasome regulatory particle (Rpt) 1 and Rpt4 of the 19S proteasome.	Quercetin	0-9	proteasome 20S subunit beta 1	Rattus norvegicus	39-76
29435775-10	2018	Quercetin also decreased the levels of proteasome subunit beta type (PSMB) 1, PSMB2, and PSMB5 of the 20S proteasome as well as the levels of proteasome regulatory particle (Rpt) 1 and Rpt4 of the 19S proteasome.	Quercetin	0-9	proteasome 20S subunit beta 2	Rattus norvegicus	78-83
29435775-10	2018	Quercetin also decreased the levels of proteasome subunit beta type (PSMB) 1, PSMB2, and PSMB5 of the 20S proteasome as well as the levels of proteasome regulatory particle (Rpt) 1 and Rpt4 of the 19S proteasome.	Quercetin	0-9	proteasome 20S subunit beta 5	Rattus norvegicus	89-94
29435775-11	2018	In particular, the PSMB5 level in the nucleus was reduced after quercetin treatment.	Quercetin	64-73	proteasome 20S subunit beta 5	Rattus norvegicus	19-24
29435775-14	2018	CONCLUSION: In summary, quercetin prevents cardiac hypertrophy, which is related to proteasome inhibition and activation of GSK-3alpha/beta.	Quercetin	24-33	glycogen synthase kinase 3 alpha	Rattus norvegicus	124-134
29207020-0	2018	Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+-calpain-p25-CDK5 pathway in HT22 cells.	Quercetin	0-9	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	98-101
29287251-0	2018	Quercetin in the experimental liver fibrosis induced by carbon tetrachloride (CCl4).	Quercetin	0-9	C-C motif chemokine ligand 4	Homo sapiens	78-82
29207037-4	2018	In addition, LPS-induced activation of extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK) was suppressed by quercetin and galangin.	Quercetin	142-151	mitogen-activated protein kinase 3	Mus musculus	39-80
29207037-4	2018	In addition, LPS-induced activation of extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK) was suppressed by quercetin and galangin.	Quercetin	142-151	mitogen-activated protein kinase 3	Mus musculus	82-88
29207037-4	2018	In addition, LPS-induced activation of extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK) was suppressed by quercetin and galangin.	Quercetin	142-151	mitogen-activated protein kinase 8	Mus musculus	94-117
29207037-4	2018	In addition, LPS-induced activation of extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK) was suppressed by quercetin and galangin.	Quercetin	142-151	mitogen-activated protein kinase 8	Mus musculus	119-122
29207037-5	2018	Taken together, these data implied that NF-kappaB, Erk1/2 and JNK may be potential molecular targets of quercetin and galangin in an LPS-induced inflammatory response.	Quercetin	104-113	mitogen-activated protein kinase 3	Mus musculus	51-57
29207037-5	2018	Taken together, these data implied that NF-kappaB, Erk1/2 and JNK may be potential molecular targets of quercetin and galangin in an LPS-induced inflammatory response.	Quercetin	104-113	mitogen-activated protein kinase 8	Mus musculus	62-65
29207020-0	2018	Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+-calpain-p25-CDK5 pathway in HT22 cells.	Quercetin	0-9	cyclin-dependent kinase 5	Mus musculus	102-106
29207037-3	2018	It was identified that quercetin and galangin markedly reduced the production of nitric oxide (NO), inducible NO synthase and interleukin-6, and the nuclear translocation of nuclear factor-kappaB (NF-kappaB).	Quercetin	23-32	interleukin 6	Mus musculus	126-139
29205806-0	2018	Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC-1alpha pathway as a potential mechanism.	Quercetin	19-28	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	94-104
28865131-14	2018	Moreover, Que up-regulated the expression of BDNF, but reduced p-JNK2 and p-STAT3 expression after acute SCI.	Quercetin	10-13	brain-derived neurotrophic factor	Rattus norvegicus	45-49
28865131-14	2018	Moreover, Que up-regulated the expression of BDNF, but reduced p-JNK2 and p-STAT3 expression after acute SCI.	Quercetin	10-13	signal transducer and activator of transcription 3	Rattus norvegicus	76-81
29205806-6	2018	Therefore, quercetin administration can potentially attenuate brain injury in a TBI model by increasing the activities of mitochondrial biogenesis via the mediation of the PGC-1alpha pathway.	Quercetin	11-20	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	172-182
29035613-0	2018	Quercetin-Induced AMP-Activated Protein Kinase Activation Attenuates Vasoconstriction Through LKB1-AMPK Signaling Pathway.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	18-46
29035613-0	2018	Quercetin-Induced AMP-Activated Protein Kinase Activation Attenuates Vasoconstriction Through LKB1-AMPK Signaling Pathway.	Quercetin	0-9	serine/threonine kinase 11	Rattus norvegicus	94-98
29035613-0	2018	Quercetin-Induced AMP-Activated Protein Kinase Activation Attenuates Vasoconstriction Through LKB1-AMPK Signaling Pathway.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	99-103
29035613-5	2018	Accordingly, the aim of this study is to investigate the molecular mechanism through which the quercetin-activated LKB1-AMPK signaling pathway regulates the contraction of VSMCs.	Quercetin	95-104	serine/threonine kinase 11	Rattus norvegicus	115-119
29035613-5	2018	Accordingly, the aim of this study is to investigate the molecular mechanism through which the quercetin-activated LKB1-AMPK signaling pathway regulates the contraction of VSMCs.	Quercetin	95-104	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	120-124
29035613-6	2018	In cultured VSMCs, quercetin activated AMPK in a dose- and time-dependent manner.	Quercetin	19-28	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	39-43
29035613-7	2018	Quercetin inhibited the phenylephrine (PE)-induced expression of MLCK and p-MLC through the LKB1-AMPK signaling pathway and decreased the mRNA level of MLCK.	Quercetin	0-9	myosin light chain kinase	Rattus norvegicus	65-69
29035613-7	2018	Quercetin inhibited the phenylephrine (PE)-induced expression of MLCK and p-MLC through the LKB1-AMPK signaling pathway and decreased the mRNA level of MLCK.	Quercetin	0-9	serine/threonine kinase 11	Rattus norvegicus	92-96
29035613-7	2018	Quercetin inhibited the phenylephrine (PE)-induced expression of MLCK and p-MLC through the LKB1-AMPK signaling pathway and decreased the mRNA level of MLCK.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	97-101
29035613-7	2018	Quercetin inhibited the phenylephrine (PE)-induced expression of MLCK and p-MLC through the LKB1-AMPK signaling pathway and decreased the mRNA level of MLCK.	Quercetin	0-9	myosin light chain kinase	Rattus norvegicus	152-156
29035613-10	2018	These data suggest that the quercetin-activated LKB1-AMPK signaling pathway regulates VSMC contraction by inhibiting MLCK and p-MLC; hence, it may be a therapeutic intervention for the treatment of cardiovascular disorders such as atherosclerosis and hypertension.	Quercetin	28-37	serine/threonine kinase 11	Rattus norvegicus	48-52
29035613-10	2018	These data suggest that the quercetin-activated LKB1-AMPK signaling pathway regulates VSMC contraction by inhibiting MLCK and p-MLC; hence, it may be a therapeutic intervention for the treatment of cardiovascular disorders such as atherosclerosis and hypertension.	Quercetin	28-37	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	53-57
29035613-10	2018	These data suggest that the quercetin-activated LKB1-AMPK signaling pathway regulates VSMC contraction by inhibiting MLCK and p-MLC; hence, it may be a therapeutic intervention for the treatment of cardiovascular disorders such as atherosclerosis and hypertension.	Quercetin	28-37	myosin light chain kinase	Rattus norvegicus	117-121
29215110-8	2018	Quercetin treatment decreased the levels of intracellular signalling proteins in PKD mouse kidneys, including phosphorylated protein kinase B (also known as AKT) and phosphorylated extracellular signal-regulated kinase (ERK), which are upregulated and promote cyst development in ADPKD.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	157-160
29272746-6	2018	To investigate the above, POD activities were measured using three different, commonly used chromophore substrates: ABTS (2,2"-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)), guaiacol (2-methoxyphenol), OPD (o-phenylenediamine) and a fourth substrate, the secondary metabolite quercetin.	Quercetin	282-291	peroxidase N1	Nicotiana tabacum	26-29
28277184-9	2018	Moreover, quercetin activated nuclear factorerythroid-2-related factor-2 (Nrf2)-mediated phase II enzymes and decreased reactive oxygen species and protein carbonylation.	Quercetin	10-19	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-72
28277184-9	2018	Moreover, quercetin activated nuclear factorerythroid-2-related factor-2 (Nrf2)-mediated phase II enzymes and decreased reactive oxygen species and protein carbonylation.	Quercetin	10-19	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78
28277184-11	2018	Taken together, these findings suggest that a reduction in mitochondrial dysfunction through the increase of AMPK activity, coupled with an increase in Nrf2 pathway mediated oxidative defence, may be one of the mechanisms by which quercetin improves cognitive impairment induced by DA in mice.	Quercetin	231-240	nuclear factor, erythroid derived 2, like 2	Mus musculus	152-156
29168878-1	2018	Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins.	Quercetin	0-9	catechol-O-methyltransferase	Homo sapiens	149-178
29168878-1	2018	Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins.	Quercetin	0-9	catechol-O-methyltransferase	Homo sapiens	180-184
29168878-8	2018	The results indicate that quercetin or fisetin is superior to ECs for methylation by COMT.	Quercetin	26-35	catechol-O-methyltransferase	Homo sapiens	85-89
29434932-0	2018	Quercetin reverses the doxorubicin resistance of prostate cancer cells by downregulating the expression of c-met.	Quercetin	0-9	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	107-112
29434932-6	2018	Notably, combination treatment of doxorubicin with quercetin significantly promoted the doxorubicin-induced apoptosis in PC3/R cells through the mitochondrial/reaction oxygen species pathway.	Quercetin	51-60	chromobox 8	Homo sapiens	121-124
29434932-8	2018	However, the response to quercetin treatment in PC3/R cells inhibited c-met expression and the downstream PI3K/AKT pathway.	Quercetin	25-34	chromobox 8	Homo sapiens	48-51
29434932-8	2018	However, the response to quercetin treatment in PC3/R cells inhibited c-met expression and the downstream PI3K/AKT pathway.	Quercetin	25-34	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	70-75
29434932-8	2018	However, the response to quercetin treatment in PC3/R cells inhibited c-met expression and the downstream PI3K/AKT pathway.	Quercetin	25-34	AKT serine/threonine kinase 1	Homo sapiens	111-114
29434932-9	2018	In addition, induced expression of c-met rescued quercetin-promoted apoptosis in PC3/R cells treated with doxorubicin.	Quercetin	49-58	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	35-40
29434932-9	2018	In addition, induced expression of c-met rescued quercetin-promoted apoptosis in PC3/R cells treated with doxorubicin.	Quercetin	49-58	chromobox 8	Homo sapiens	81-84
29434932-10	2018	The results of the present study indicated that quercetin is able to reverse prostate cancer cell doxorubicin resistance by downregulating the expression of c-met.	Quercetin	48-57	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	157-162
29168292-0	2018	Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers.	Quercetin	28-37	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	51-57
29168292-9	2018	The results suggest that quercetin might have inhibited CYP2C9-mediated metabolism of DIC.	Quercetin	25-34	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	56-62
29391509-4	2018	In-vitro experiments showed that quercetin can enhance ZD55-TRAIL mediated growth inhibition and apoptosis in HCC cells.	Quercetin	33-42	TNF superfamily member 10	Homo sapiens	60-65
29391509-5	2018	In addition, we showed that quercetin reduced ZD55-TRAIL mediated NF-kappaB activation and down-regulated its downstream targets, which in turn promoted the pro-apoptotic action of ZD55-TRAIL.	Quercetin	28-37	TNF superfamily member 10	Homo sapiens	51-56
29391509-5	2018	In addition, we showed that quercetin reduced ZD55-TRAIL mediated NF-kappaB activation and down-regulated its downstream targets, which in turn promoted the pro-apoptotic action of ZD55-TRAIL.	Quercetin	28-37	TNF superfamily member 10	Homo sapiens	186-191
29391509-7	2018	In conclusion, we demonstrated that quercetin could sensitize human HCC cells to apoptosis via ZD55-TRAIL in-vitro and in-vivo and presented ZD55-TRAIL and quercetin combination as a suitable anti-HCC therapy.	Quercetin	36-45	TNF superfamily member 10	Homo sapiens	100-105
29391509-7	2018	In conclusion, we demonstrated that quercetin could sensitize human HCC cells to apoptosis via ZD55-TRAIL in-vitro and in-vivo and presented ZD55-TRAIL and quercetin combination as a suitable anti-HCC therapy.	Quercetin	36-45	TNF superfamily member 10	Homo sapiens	146-151
29370120-6	2018	Dietary VMP supplementation for 56 days significantly increased circulating levels of quercetin, vitamin C, RBC folate and partially prevented the decline in vitamin B6 and B12 status.	Quercetin	86-95	neurensin 1	Homo sapiens	8-11
29292466-0	2018	Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARgamma/LXRalpha pathway.	Quercetin	0-9	scavenger receptor class B member 1	Homo sapiens	72-77
29292466-0	2018	Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARgamma/LXRalpha pathway.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	115-124
29292466-0	2018	Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARgamma/LXRalpha pathway.	Quercetin	0-9	nuclear receptor subfamily 1 group H member 3	Homo sapiens	125-133
29292466-3	2018	In the present study, we explored the modulation of hepatic SR-BI expression and SR-BI-mediated SLU by quercetin, a natural flavonoid compound in the diet with a favorable role in cardiovascular disorders.	Quercetin	103-112	scavenger receptor class B member 1	Homo sapiens	60-65
29292466-3	2018	In the present study, we explored the modulation of hepatic SR-BI expression and SR-BI-mediated SLU by quercetin, a natural flavonoid compound in the diet with a favorable role in cardiovascular disorders.	Quercetin	103-112	scavenger receptor class B member 1	Homo sapiens	81-86
29292466-4	2018	We found that quercetin significantly increased the expression level of SR-BI in HepG2 cells in a concentration- and time-dependent manner.	Quercetin	14-23	scavenger receptor class B member 1	Homo sapiens	72-77
29292466-6	2018	Treatment with small interfering RNA (siRNA) or SR-BI specific inhibitor, BLT-1, inhibited quercetin-induced Dil-HDL binding and selective HDL-C uptake.	Quercetin	91-100	leukotriene B4 receptor	Homo sapiens	48-79
29292466-7	2018	Treatment with quercetin increased both proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha (LXRalpha) levels.	Quercetin	15-24	peroxisome proliferator activated receptor gamma	Homo sapiens	79-88
29292466-7	2018	Treatment with quercetin increased both proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha (LXRalpha) levels.	Quercetin	15-24	nuclear receptor subfamily 1 group H member 3	Homo sapiens	118-126
29292466-8	2018	Additionally, the quercetin-induced expression of SR-BI, Dil-HDL binding and the selective uptake of HDL-C were significantly attenuated by treatment with PPARgamma siRNA, LXRalpha siRNA, and their antagonists, respectively.	Quercetin	18-27	scavenger receptor class B member 1	Homo sapiens	50-55
29292466-8	2018	Additionally, the quercetin-induced expression of SR-BI, Dil-HDL binding and the selective uptake of HDL-C were significantly attenuated by treatment with PPARgamma siRNA, LXRalpha siRNA, and their antagonists, respectively.	Quercetin	18-27	peroxisome proliferator activated receptor gamma	Homo sapiens	155-164
29215110-8	2018	Quercetin treatment decreased the levels of intracellular signalling proteins in PKD mouse kidneys, including phosphorylated protein kinase B (also known as AKT) and phosphorylated extracellular signal-regulated kinase (ERK), which are upregulated and promote cyst development in ADPKD.	Quercetin	0-9	mitogen-activated protein kinase 1	Mus musculus	181-218
29292466-8	2018	Additionally, the quercetin-induced expression of SR-BI, Dil-HDL binding and the selective uptake of HDL-C were significantly attenuated by treatment with PPARgamma siRNA, LXRalpha siRNA, and their antagonists, respectively.	Quercetin	18-27	nuclear receptor subfamily 1 group H member 3	Homo sapiens	172-180
29292466-9	2018	In C57BL/6 mice, quercetin administration potently increased SR-BI, PPARgamma and LXRalpha levels and lipid accumulation in the liver.	Quercetin	17-26	scavenger receptor class B, member 1	Mus musculus	61-66
29292466-9	2018	In C57BL/6 mice, quercetin administration potently increased SR-BI, PPARgamma and LXRalpha levels and lipid accumulation in the liver.	Quercetin	17-26	peroxisome proliferator activated receptor gamma	Mus musculus	68-77
29292466-9	2018	In C57BL/6 mice, quercetin administration potently increased SR-BI, PPARgamma and LXRalpha levels and lipid accumulation in the liver.	Quercetin	17-26	nuclear receptor subfamily 1, group H, member 3	Mus musculus	82-90
29292466-10	2018	Altogether, our results suggest that quercetin-induced up-regulation of SR-BI and subsequent lipid uptake in hepatocytes might contribute to its beneficial effects on cholesterol homeostasis and atherogenesis.	Quercetin	37-46	scavenger receptor class B member 1	Homo sapiens	72-77
29215110-8	2018	Quercetin treatment decreased the levels of intracellular signalling proteins in PKD mouse kidneys, including phosphorylated protein kinase B (also known as AKT) and phosphorylated extracellular signal-regulated kinase (ERK), which are upregulated and promote cyst development in ADPKD.	Quercetin	0-9	mitogen-activated protein kinase 1	Mus musculus	220-223
29215110-9	2018	Quercetin also reversed E-cadherin expression, which is localized in normal proximal tubules in PKD mouse kidneys.	Quercetin	0-9	cadherin 1	Mus musculus	24-34
29364834-0	2018	Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells.	Quercetin	0-9	cellular communication network factor 1	Homo sapiens	21-26
29353288-0	2018	Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).	Quercetin	0-9	aldehyde dehydrogenase 1 family member A1	Homo sapiens	66-92
29364834-3	2018	Among the tested flavones, quercetin had the lowest 50% inhibitory concentration (IC50) and significantly reduced the viability of AGS-cyr61 cells compared with AGS cells.	Quercetin	27-36	cellular communication network factor 1	Homo sapiens	135-140
29364834-4	2018	Quercetin: (1) reduced multidrug resistance-associated protein 1 and nuclear factor (NF)-kappa B p65 subunit levels; (2) reversed multidrug resistance (MDR); (3) inhibited colony formation and induced caspase-dependent apoptosis; and (4) suppressed migration and down-regulated epithelial-mesenchymal transition-related proteins in AGS-cyr61.	Quercetin	0-9	cellular communication network factor 1	Homo sapiens	336-341
29364834-5	2018	Moreover, AGS-cyr61 cells treated with quercetin concentrations close to the IC50 and simultaneously treated with 5-FU or ADR in the sub-lethal range showed strong synergism between quercetin and these two drugs.	Quercetin	39-48	cellular communication network factor 1	Homo sapiens	14-19
29364834-5	2018	Moreover, AGS-cyr61 cells treated with quercetin concentrations close to the IC50 and simultaneously treated with 5-FU or ADR in the sub-lethal range showed strong synergism between quercetin and these two drugs.	Quercetin	182-191	cellular communication network factor 1	Homo sapiens	14-19
29364834-6	2018	These findings indicate that CYR61 is a potential regulator of drug resistance and that quercetin may be a novel agent for improving the efficacy of anticancer drugs in AGS-cyr61 cells.	Quercetin	88-97	cellular communication network factor 1	Homo sapiens	173-178
29353288-0	2018	Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).	Quercetin	0-9	aldehyde dehydrogenase 1 family member A1	Homo sapiens	94-101
29353288-0	2018	Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).	Quercetin	0-9	C-X-C motif chemokine receptor 4	Homo sapiens	131-136
29353288-0	2018	Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).	Quercetin	0-9	mucin 1, cell surface associated	Homo sapiens	139-146
29353288-0	2018	Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).	Quercetin	0-9	mucin 1, cell surface associated	Homo sapiens	148-152
29353288-0	2018	Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).	Quercetin	0-9	epithelial cell adhesion molecule	Homo sapiens	159-192
29353288-0	2018	Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).	Quercetin	0-9	epithelial cell adhesion molecule	Homo sapiens	194-199
29576853-7	2018	Quercetin also counteracted HC-induced bioenergetic impairment, preventing a reduction in ATP levels and alterations in PGC-1alpha, UCP2, and PPARgamma expression.	Quercetin	0-9	PPARG coactivator 1 alpha	Rattus norvegicus	120-130
29169872-5	2018	In addition, quercetin reduced the pancreatic ER stress-induced endothelial dysfunction as assessed by immunohistochemical analysis of C/ERB homologous protein (CHOP) and endothelin-1 (ET-1).	Quercetin	13-22	DNA-damage inducible transcript 3	Rattus norvegicus	135-159
29169872-5	2018	In addition, quercetin reduced the pancreatic ER stress-induced endothelial dysfunction as assessed by immunohistochemical analysis of C/ERB homologous protein (CHOP) and endothelin-1 (ET-1).	Quercetin	13-22	DNA-damage inducible transcript 3	Rattus norvegicus	161-165
29169872-5	2018	In addition, quercetin reduced the pancreatic ER stress-induced endothelial dysfunction as assessed by immunohistochemical analysis of C/ERB homologous protein (CHOP) and endothelin-1 (ET-1).	Quercetin	13-22	endothelin 1	Rattus norvegicus	171-183
29169872-6	2018	Moreover, quercetin administration progressively increased the expression of vascular endothelial growth factor (VEGF) and its receptor, VEGFR2 in diabetes rats.	Quercetin	10-19	vascular endothelial growth factor A	Rattus norvegicus	77-111
29169872-6	2018	Moreover, quercetin administration progressively increased the expression of vascular endothelial growth factor (VEGF) and its receptor, VEGFR2 in diabetes rats.	Quercetin	10-19	vascular endothelial growth factor A	Rattus norvegicus	113-117
29169872-6	2018	Moreover, quercetin administration progressively increased the expression of vascular endothelial growth factor (VEGF) and its receptor, VEGFR2 in diabetes rats.	Quercetin	10-19	kinase insert domain receptor	Rattus norvegicus	137-143
29434473-0	2018	TRAIL-Induced Apoptosis in TRAIL-Resistant Breast Carcinoma Through Quercetin Cotreatment.	Quercetin	68-77	TNF superfamily member 10	Homo sapiens	0-5
29434473-0	2018	TRAIL-Induced Apoptosis in TRAIL-Resistant Breast Carcinoma Through Quercetin Cotreatment.	Quercetin	68-77	TNF superfamily member 10	Homo sapiens	27-32
29434473-6	2018	Quercetin was able to sensitize rhTRAIL-resistant breast cancers to rhTRAIL-induced apoptosis as detected by Western blotting through the proteasome-mediated degradation of c-FLIPL and through the upregulation of DR5 expression transcriptionally.	Quercetin	0-9	CASP8 and FADD like apoptosis regulator	Homo sapiens	173-180
29434473-6	2018	Quercetin was able to sensitize rhTRAIL-resistant breast cancers to rhTRAIL-induced apoptosis as detected by Western blotting through the proteasome-mediated degradation of c-FLIPL and through the upregulation of DR5 expression transcriptionally.	Quercetin	0-9	TNF receptor superfamily member 10b	Homo sapiens	213-216
29568754-7	2018	Quercetin and flavonoids significantly contributed to MAO-A inhibition.	Quercetin	0-9	monoamine oxidase A	Homo sapiens	54-59
29576853-7	2018	Quercetin also counteracted HC-induced bioenergetic impairment, preventing a reduction in ATP levels and alterations in PGC-1alpha, UCP2, and PPARgamma expression.	Quercetin	0-9	uncoupling protein 2	Rattus norvegicus	132-136
29576853-7	2018	Quercetin also counteracted HC-induced bioenergetic impairment, preventing a reduction in ATP levels and alterations in PGC-1alpha, UCP2, and PPARgamma expression.	Quercetin	0-9	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	142-151
29129327-0	2018	Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells.	Quercetin	0-9	Cd68 molecule	Rattus norvegicus	108-112
29281744-6	2018	Administration of GbE, rutin and quercetin remarkably inhibited the AR activity, stimulated the production of glutathione, and decreased the levels of MDA and AGEs in the lenses of DC-induced rats, which eventually delayed the progression of lens opacification in diabetic rats to various degrees.	Quercetin	33-42	aldo-keto reductase family 1 member B1	Rattus norvegicus	68-70
29281744-8	2018	The mechanism dictating this interesting prowess of quercetin might be attributed to its AR inhibitory strength, anti-lipid peroxidation potential and anti-AGEs activity.	Quercetin	52-61	aldo-keto reductase family 1 member B1	Rattus norvegicus	89-91
29129327-4	2018	In the group with applied quercetin, the significantly increased (p&lt;0.001) levels of anti-inflammatory cytokine IL10 were observed both in the blood serum and jejunal tissue.	Quercetin	26-35	interleukin 10	Rattus norvegicus	115-119
29444501-0	2018	Quercetin Therapy for Selected Patients with PIM1 Kinase-Positive Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Pilot Study.	Quercetin	0-9	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	45-49
29129327-5	2018	The improvement of the mucosal tissue morphology and proliferating and DNA repairing cell number measured by PCNA activity were recorded by more than 30% higher in the quercetin group.	Quercetin	168-177	proliferating cell nuclear antigen	Rattus norvegicus	109-113
29444501-2	2018	Quercetin, a naturally occurring flavonoid, is a dietary supplement and inhibits many kinases, including PIM1, in vitro.	Quercetin	0-9	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	105-109
29433393-7	2018	Ultra-performance liquid chromatography analysis showed that EKE contained icariin, icaritin, and quercetin; icaritin and quercetin were both found to protect HepG2 cells from AA[Formula: see text][Formula: see text][Formula: see text]iron via Nrf2 activation.	Quercetin	122-131	NFE2 like bZIP transcription factor 2	Homo sapiens	244-248
29737207-6	2018	Silencing LPL increased the expression levels of senescence proteins such as p16INK4A and p53 and silencing KCNE2 reversed gene expressions of EGR1 and p-ERK in quercetin-treated aged HDFs.	Quercetin	161-170	lipoprotein lipase	Homo sapiens	10-13
29737207-6	2018	Silencing LPL increased the expression levels of senescence proteins such as p16INK4A and p53 and silencing KCNE2 reversed gene expressions of EGR1 and p-ERK in quercetin-treated aged HDFs.	Quercetin	161-170	tumor protein p53	Homo sapiens	90-93
28976231-0	2018	Dietary quercetin ameliorates experimental colitis in mouse by remodeling the function of colonic macrophages via a heme oxygenase-1-dependent pathway.	Quercetin	8-17	heme oxygenase 1	Mus musculus	116-132
29737207-6	2018	Silencing LPL increased the expression levels of senescence proteins such as p16INK4A and p53 and silencing KCNE2 reversed gene expressions of EGR1 and p-ERK in quercetin-treated aged HDFs.	Quercetin	161-170	potassium voltage-gated channel subfamily E regulatory subunit 2	Homo sapiens	108-113
29737207-6	2018	Silencing LPL increased the expression levels of senescence proteins such as p16INK4A and p53 and silencing KCNE2 reversed gene expressions of EGR1 and p-ERK in quercetin-treated aged HDFs.	Quercetin	161-170	early growth response 1	Homo sapiens	143-147
29737207-6	2018	Silencing LPL increased the expression levels of senescence proteins such as p16INK4A and p53 and silencing KCNE2 reversed gene expressions of EGR1 and p-ERK in quercetin-treated aged HDFs.	Quercetin	161-170	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	152-157
29405727-0	2018	Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain.	Quercetin	10-19	brain-derived neurotrophic factor	Rattus norvegicus	27-60
29405727-4	2018	In the present study, we aimed to investigate the effects of quercetin on expression of BDNF mRNA in the hippocampus of rat brain.	Quercetin	61-70	brain-derived neurotrophic factor	Rattus norvegicus	88-92
29405727-7	2018	RESULTS: Quercetin at doses of 20 and 50 mg/kg caused a significant increase in the mRNA expression of BDNF as compared with the control group.	Quercetin	9-18	brain-derived neurotrophic factor	Rattus norvegicus	103-107
29105398-0	2018	Oral Quercetin Supplementation Enhances Adiponectin Receptor Transcript Expression in Polycystic Ovary Syndrome Patients: A Randomized Placebo-Controlled Double-Blind Clinical Trial.	Quercetin	5-14	adiponectin, C1Q and collagen domain containing	Homo sapiens	40-51
29105398-4	2018	In the present study, we investigated the effect of quercetin supplementation on the expression of adiponectin receptors at the transcript level in peripheral blood mononuclear cells (PBMC) samples of PCOS patients.	Quercetin	52-61	adiponectin, C1Q and collagen domain containing	Homo sapiens	99-110
30481789-6	2018	Quercetin, the AEM and NAC showed a significant inhibitory effect on both ICAM-1 expression and ROS generation (p&lt;0.05).	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	74-80
29105398-7	2018	RESULTS: Oral quercetin supplementation significantly increased ADIPOR1 and ADIPOR2 transcript expression by 1.32- and 1.46-fold respecetively (P&lt;0.01).	Quercetin	14-23	adiponectin receptor 1	Homo sapiens	64-71
29105398-7	2018	RESULTS: Oral quercetin supplementation significantly increased ADIPOR1 and ADIPOR2 transcript expression by 1.32- and 1.46-fold respecetively (P&lt;0.01).	Quercetin	14-23	adiponectin receptor 2	Homo sapiens	76-83
29105398-8	2018	In addition, quercetin supplementation enhanced AMPK level by 12.3% compared with the control group (P&lt;0.05).	Quercetin	13-22	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	48-52
29105398-9	2018	CONCLUSIONS: Oral quercetin supplementation improves the metabolic features of PCOS patients by upregulating the expression of adiponectin receptors and AMPK (Registration Number: IRCT2013112515536N1).	Quercetin	18-27	adiponectin, C1Q and collagen domain containing	Homo sapiens	127-138
29105398-9	2018	CONCLUSIONS: Oral quercetin supplementation improves the metabolic features of PCOS patients by upregulating the expression of adiponectin receptors and AMPK (Registration Number: IRCT2013112515536N1).	Quercetin	18-27	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	153-157
30799996-8	2018	Quercetin exerts physiological functions though the interaction with phosphatidylinositol-3-phosphate kinase (PI3K), mitogen-activated protein kinase (MAPK), extracellular signal regulated kinase (ERK), kinase (MEK) 1, and others, and has a negative effect on FceRI cross-linking and other activating receptors on mast cells.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	197-200
29080804-5	2018	In mouse model with LPS-induced acute kidney injury, blocking CD38 with quercetin could significantly relieve kidney dysfunction, kidney pathological changes as well as inflammatory cell accumulation.	Quercetin	72-81	CD38 antigen	Mus musculus	62-66
30799996-8	2018	Quercetin exerts physiological functions though the interaction with phosphatidylinositol-3-phosphate kinase (PI3K), mitogen-activated protein kinase (MAPK), extracellular signal regulated kinase (ERK), kinase (MEK) 1, and others, and has a negative effect on FceRI cross-linking and other activating receptors on mast cells.	Quercetin	0-9	mitogen-activated protein kinase kinase 1	Homo sapiens	102-109
30799996-8	2018	Quercetin exerts physiological functions though the interaction with phosphatidylinositol-3-phosphate kinase (PI3K), mitogen-activated protein kinase (MAPK), extracellular signal regulated kinase (ERK), kinase (MEK) 1, and others, and has a negative effect on FceRI cross-linking and other activating receptors on mast cells.	Quercetin	0-9	mitogen-activated protein kinase kinase 1	Homo sapiens	143-150
30799996-8	2018	Quercetin exerts physiological functions though the interaction with phosphatidylinositol-3-phosphate kinase (PI3K), mitogen-activated protein kinase (MAPK), extracellular signal regulated kinase (ERK), kinase (MEK) 1, and others, and has a negative effect on FceRI cross-linking and other activating receptors on mast cells.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	158-195
30799996-8	2018	Quercetin exerts physiological functions though the interaction with phosphatidylinositol-3-phosphate kinase (PI3K), mitogen-activated protein kinase (MAPK), extracellular signal regulated kinase (ERK), kinase (MEK) 1, and others, and has a negative effect on FceRI cross-linking and other activating receptors on mast cells.	Quercetin	0-9	mitogen-activated protein kinase kinase 1	Homo sapiens	203-217
30799996-8	2018	Quercetin exerts physiological functions though the interaction with phosphatidylinositol-3-phosphate kinase (PI3K), mitogen-activated protein kinase (MAPK), extracellular signal regulated kinase (ERK), kinase (MEK) 1, and others, and has a negative effect on FceRI cross-linking and other activating receptors on mast cells.	Quercetin	0-9	Fc epsilon receptor Ia	Homo sapiens	260-265
29542424-6	2018	RESULTS: Our results demonstrate that combined treatment of caloric restriction and quercetin significantly improved the age associated decline in the activities of endogenous antioxidant enzymes [such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] and glutathione (GSH) content and attenuated elevated levels of protein carbonyl content (PCC), lipid peroxidation, lipofuscin, reactive oxygen species (ROS), and nitric oxide (NO).	Quercetin	84-93	catalase	Rattus norvegicus	233-241
29542424-6	2018	RESULTS: Our results demonstrate that combined treatment of caloric restriction and quercetin significantly improved the age associated decline in the activities of endogenous antioxidant enzymes [such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] and glutathione (GSH) content and attenuated elevated levels of protein carbonyl content (PCC), lipid peroxidation, lipofuscin, reactive oxygen species (ROS), and nitric oxide (NO).	Quercetin	84-93	catalase	Rattus norvegicus	243-246
27655075-4	2018	We have found the stimulatory action of quercetin on Cl- transporter, Na+-K+-2Cl- cotransporter 1 (NKCC1; an isoform of NKCC), which has been recognized as one of the most interesting, fundamental actions of quercetin.	Quercetin	40-49	solute carrier family 12 member 2	Homo sapiens	70-97
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Quercetin	50-59	NFE2 like bZIP transcription factor 2	Homo sapiens	135-178
27655075-4	2018	We have found the stimulatory action of quercetin on Cl- transporter, Na+-K+-2Cl- cotransporter 1 (NKCC1; an isoform of NKCC), which has been recognized as one of the most interesting, fundamental actions of quercetin.	Quercetin	40-49	solute carrier family 12 member 2	Homo sapiens	99-104
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Quercetin	50-59	NFE2 like bZIP transcription factor 2	Homo sapiens	180-184
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Quercetin	50-59	heme oxygenase 1	Homo sapiens	239-255
27655075-4	2018	We have found the stimulatory action of quercetin on Cl- transporter, Na+-K+-2Cl- cotransporter 1 (NKCC1; an isoform of NKCC), which has been recognized as one of the most interesting, fundamental actions of quercetin.	Quercetin	208-217	solute carrier family 12 member 2	Homo sapiens	70-97
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Quercetin	50-59	heme oxygenase 1	Homo sapiens	257-261
27655075-4	2018	We have found the stimulatory action of quercetin on Cl- transporter, Na+-K+-2Cl- cotransporter 1 (NKCC1; an isoform of NKCC), which has been recognized as one of the most interesting, fundamental actions of quercetin.	Quercetin	208-217	solute carrier family 12 member 2	Homo sapiens	99-104
27655075-5	2018	In this review article, based on this stimulatory action of quercetin on NKCC1, we introduce the molecular mechanism of quercetin on: 1) blood pressure, 2) neurite elongation, and 3) epithelial Cl- secretion including tight junction forming in epithelial tissues.	Quercetin	60-69	solute carrier family 12 member 2	Homo sapiens	73-78
27655075-5	2018	In this review article, based on this stimulatory action of quercetin on NKCC1, we introduce the molecular mechanism of quercetin on: 1) blood pressure, 2) neurite elongation, and 3) epithelial Cl- secretion including tight junction forming in epithelial tissues.	Quercetin	120-129	solute carrier family 12 member 2	Homo sapiens	73-78
27655075-6	2018	1) Quercetin induces elevation of the cytosolic Cl- concentration via activation of NKCC1, leading to anti-hypertensive action by diminishing expression of epithelial Na+ channel (ENaC), a key ion channel involved in renal Na+ reabsorption, while quercetin has no effects on the blood pressure with normal salt intake.	Quercetin	3-12	solute carrier family 12 member 2	Homo sapiens	84-89
27655075-6	2018	1) Quercetin induces elevation of the cytosolic Cl- concentration via activation of NKCC1, leading to anti-hypertensive action by diminishing expression of epithelial Na+ channel (ENaC), a key ion channel involved in renal Na+ reabsorption, while quercetin has no effects on the blood pressure with normal salt intake.	Quercetin	247-256	solute carrier family 12 member 2	Homo sapiens	84-89
27655075-7	2018	2) Quercetin also has stimulatory effects on neurite elongation by elevating the cytosolic Cl- concentration via activation of NKCC1 due to tubulin polymerization facilitated through Cl--induced inhibition of GTPase.	Quercetin	3-12	solute carrier family 12 member 2	Homo sapiens	127-132
29122665-2	2018	Herein, we aimed to explore dual combinations of the flavonoids baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin to reverse the interference of P-gp on the intracellular accumulation of antiepileptic drugs (AEDs).	Quercetin	117-126	PGP	Canis lupus familiaris	172-176
28983678-1	2018	PURPOSE: Previous in vitro studies have demonstrated that quercetin inhibits CYP2E1 enzyme, but there are no available data to indicate that quercetin inhibits CYP2E1 enzyme in humans.	Quercetin	58-67	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	77-83
28983678-1	2018	PURPOSE: Previous in vitro studies have demonstrated that quercetin inhibits CYP2E1 enzyme, but there are no available data to indicate that quercetin inhibits CYP2E1 enzyme in humans.	Quercetin	141-150	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	160-166
28983678-2	2018	The purpose of the present study was to assess the effect of quercetin on CYP2E1 enzyme activity in healthy subjects using chlorzoxazone (CHZ) as a CYP2E1 substrate.	Quercetin	61-70	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	74-80
28983678-11	2018	CONCLUSIONS: The results suggest that altered pharmacokinetics of CHZ might be attributed to quercetin-mediated inhibition of CYP2E1 enzyme.	Quercetin	93-102	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	126-132
28983678-12	2018	Further, the inhibition of CYP2E1 by quercetin may represent a novel therapeutic approach for minimizing the ethanol-induced CYP2E1 enzyme activity and results in reduced hepatotoxicity of ethanol.	Quercetin	37-46	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	27-33
28983678-12	2018	Further, the inhibition of CYP2E1 by quercetin may represent a novel therapeutic approach for minimizing the ethanol-induced CYP2E1 enzyme activity and results in reduced hepatotoxicity of ethanol.	Quercetin	37-46	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	125-131
29389596-6	2018	Overall, the results showed that baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin, at 200muM, produced a marked increase on the intracellular accumulation of rhodamine 123 in MDCK-MDR1 cells, potentially through inhibiting the P-gp activity.	Quercetin	86-95	ATP binding cassette subfamily B member 1	Canis lupus familiaris	203-212
29389596-6	2018	Overall, the results showed that baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin, at 200muM, produced a marked increase on the intracellular accumulation of rhodamine 123 in MDCK-MDR1 cells, potentially through inhibiting the P-gp activity.	Quercetin	86-95	PGP	Canis lupus familiaris	255-259
29424356-1	2018	Water-soluble analogue of quercetin, corvitin is used in patients with myocardial infarction as blocker of 5-lipoxygenase.	Quercetin	26-35	arachidonate 5-lipoxygenase	Homo sapiens	107-121
30392493-8	2018	Under the influence of quercetin, levels of IL-1beta and TNF-alpha were reduced and IL-10 levels tended to decrease.	Quercetin	23-32	interleukin 1 beta	Homo sapiens	44-52
30392493-8	2018	Under the influence of quercetin, levels of IL-1beta and TNF-alpha were reduced and IL-10 levels tended to decrease.	Quercetin	23-32	tumor necrosis factor	Homo sapiens	57-66
30392493-8	2018	Under the influence of quercetin, levels of IL-1beta and TNF-alpha were reduced and IL-10 levels tended to decrease.	Quercetin	23-32	interleukin 10	Homo sapiens	84-89
30392493-10	2018	The administration of quercetin decreased the expression of the IkBalpha gene (0.0092+-0.0033 against 0.0261+-0.0166, r=0.003; 2-deltadeltaSt, 2.82+-1.39 times) in contrast to the control group.	Quercetin	22-31	NFKB inhibitor alpha	Homo sapiens	64-72
30701264-6	2018	Overall, this demonstrated that quercetin could block the pro-inflammatory actions of N-SMase and augment the efficacy of anti-AML therapeutics, including ceramide-based therapeutics.	Quercetin	32-41	sphingomyelin phosphodiesterase 2	Homo sapiens	86-93
29149703-0	2018	Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	102-118
29125991-4	2018	The in vitro study evaluated the efficacy of high-dose SN-38 and quercetin combined with low-dose SN-38 on cell viability, apoptosis, and beta-catenin expression.	Quercetin	65-74	catenin beta 1	Homo sapiens	138-150
29371754-0	2018	Glutathione homeostasis is significantly altered by quercetin via the Keap1/Nrf2 and MAPK signaling pathways in rats.	Quercetin	52-61	Kelch-like ECH-associated protein 1	Rattus norvegicus	70-75
29371754-0	2018	Glutathione homeostasis is significantly altered by quercetin via the Keap1/Nrf2 and MAPK signaling pathways in rats.	Quercetin	52-61	NFE2 like bZIP transcription factor 2	Rattus norvegicus	76-80
29371754-0	2018	Glutathione homeostasis is significantly altered by quercetin via the Keap1/Nrf2 and MAPK signaling pathways in rats.	Quercetin	52-61	mitogen activated protein kinase 3	Rattus norvegicus	85-89
29371754-4	2018	The results showed that quercetin reduced serum and hepatic content of GSH and the ratio of GSH and oxidized glutathione (GSSG), enhanced hepatic activity and mRNA expression of glutathione S-transferase (GST), inhibited hepatic activity and mRNA expression of glutamate cysteine ligase (GCL), and decreased hepatic glutathione reductase (GR) mRNA expression.	Quercetin	24-33	hematopoietic prostaglandin D synthase	Rattus norvegicus	178-203
29371754-4	2018	The results showed that quercetin reduced serum and hepatic content of GSH and the ratio of GSH and oxidized glutathione (GSSG), enhanced hepatic activity and mRNA expression of glutathione S-transferase (GST), inhibited hepatic activity and mRNA expression of glutamate cysteine ligase (GCL), and decreased hepatic glutathione reductase (GR) mRNA expression.	Quercetin	24-33	hematopoietic prostaglandin D synthase	Rattus norvegicus	205-208
29371754-4	2018	The results showed that quercetin reduced serum and hepatic content of GSH and the ratio of GSH and oxidized glutathione (GSSG), enhanced hepatic activity and mRNA expression of glutathione S-transferase (GST), inhibited hepatic activity and mRNA expression of glutamate cysteine ligase (GCL), and decreased hepatic glutathione reductase (GR) mRNA expression.	Quercetin	24-33	glutathione-disulfide reductase	Rattus norvegicus	316-337
29371754-4	2018	The results showed that quercetin reduced serum and hepatic content of GSH and the ratio of GSH and oxidized glutathione (GSSG), enhanced hepatic activity and mRNA expression of glutathione S-transferase (GST), inhibited hepatic activity and mRNA expression of glutamate cysteine ligase (GCL), and decreased hepatic glutathione reductase (GR) mRNA expression.	Quercetin	24-33	glutathione-disulfide reductase	Rattus norvegicus	339-341
29371754-5	2018	Levels of phosphorylated p38 and extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinases (MAPKs) increased, while that of nuclear factor E2-like 2 (Nrf2) protein decreased after quercetin treatment.	Quercetin	204-213	mitogen activated protein kinase 14	Rattus norvegicus	25-28
29371754-5	2018	Levels of phosphorylated p38 and extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinases (MAPKs) increased, while that of nuclear factor E2-like 2 (Nrf2) protein decreased after quercetin treatment.	Quercetin	204-213	NFE2 like bZIP transcription factor 2	Rattus norvegicus	174-178
29371754-7	2018	We concluded that quercetin treatment altered hepatic GSH metabolism by modulating GSH metabolic enzyme activities and mRNA expression in rats, and p38, ERK1/2 MAPKs, and Nrf2 were involved in modulating GSH metabolism-related enzymes.	Quercetin	18-27	mitogen activated protein kinase 14	Rattus norvegicus	148-151
29125991-6	2018	AGS cells treated with a high dose of SN-38 exhibited up-regulation of beta-catenin protein expression, whereas quercetin-treated cells (either quercetin alone or combined with low-dose SN-38) exhibited lower protein levels of beta-catenin.	Quercetin	112-121	catenin beta 1	Homo sapiens	227-239
29125991-6	2018	AGS cells treated with a high dose of SN-38 exhibited up-regulation of beta-catenin protein expression, whereas quercetin-treated cells (either quercetin alone or combined with low-dose SN-38) exhibited lower protein levels of beta-catenin.	Quercetin	144-153	catenin beta 1	Homo sapiens	227-239
29125991-7	2018	In the AGS xenograft mouse model, gene expression of cyclooxygenase-2 and epithelial-mesenchymal transition-related markers, such as Twist1 and ITGbeta6, were lower in combined treatments with quercetin and low-dose irinotecan than high-dose irinotecan alone.	Quercetin	193-202	prostaglandin-endoperoxide synthase 2	Mus musculus	53-69
29125991-7	2018	In the AGS xenograft mouse model, gene expression of cyclooxygenase-2 and epithelial-mesenchymal transition-related markers, such as Twist1 and ITGbeta6, were lower in combined treatments with quercetin and low-dose irinotecan than high-dose irinotecan alone.	Quercetin	193-202	twist basic helix-loop-helix transcription factor 1	Mus musculus	133-139
29125991-8	2018	Furthermore, the concentration of angiogenesis-associated factors (vascular endothelial growth factor (VEGF)-A and VEGF-receptor 2) and percentage of Tie2-expressing monocytes was significantly down-regulated in combined treatments with quercetin and irinotecan.	Quercetin	237-246	vascular endothelial growth factor A	Homo sapiens	67-101
29125991-8	2018	Furthermore, the concentration of angiogenesis-associated factors (vascular endothelial growth factor (VEGF)-A and VEGF-receptor 2) and percentage of Tie2-expressing monocytes was significantly down-regulated in combined treatments with quercetin and irinotecan.	Quercetin	237-246	vascular endothelial growth factor A	Homo sapiens	103-107
29125991-8	2018	Furthermore, the concentration of angiogenesis-associated factors (vascular endothelial growth factor (VEGF)-A and VEGF-receptor 2) and percentage of Tie2-expressing monocytes was significantly down-regulated in combined treatments with quercetin and irinotecan.	Quercetin	237-246	vascular endothelial growth factor A	Homo sapiens	115-119
29125991-8	2018	Furthermore, the concentration of angiogenesis-associated factors (vascular endothelial growth factor (VEGF)-A and VEGF-receptor 2) and percentage of Tie2-expressing monocytes was significantly down-regulated in combined treatments with quercetin and irinotecan.	Quercetin	237-246	TEK receptor tyrosine kinase	Homo sapiens	150-154
29576694-8	2018	Conclusion: The results of the present study concluded that the P. guajava leaf and its isolated quercetin fraction can significantly regulate lipid metabolism in CCl4-induced hepatotoxic rats and decrease the disease rate.	Quercetin	97-106	C-C motif chemokine ligand 4	Rattus norvegicus	163-167
27334466-6	2018	Some polyphenolic natural products such as Resveratrol, Fisetin, and Quercetin have demonstrated health benefits due to their SIRT1 activation effects.	Quercetin	69-78	sirtuin 1	Homo sapiens	126-131
29227203-4	2018	Major signaling pathways including NF-kappaB, MAPK, PI3K-AKT and mTOR are found to be regulated by quercetin.	Quercetin	99-108	mapk	None	46-50
29337672-6	2017	The best rheological properties were shown by formulation F-3, containing 1.5 % of quercetin and 2 % of plasma.	Quercetin	83-92	coagulation factor III, tissue factor	Homo sapiens	58-61
29100712-0	2018	[Quercetin attenuates Staphylococcus aureus virulence by reducing alpha-toxin secretion].	Quercetin	1-10	AT695_RS01930	Staphylococcus aureus	72-77
29100712-4	2018	This study shows that quercetin, a naturally occurring flavonoid, inhibits hemolytic activity in a dose-dependent manner and reduces alpha toxin secretion in culture supernatants of methicillin-sensitive and methicillin-resistant S.aureus.	Quercetin	22-31	AT695_RS01930	Staphylococcus aureus	139-144
29100712-6	2018	Our results suggest that quercetin can reduce S.aureus virulence by affecting alpha-toxin secretion.	Quercetin	25-34	AT695_RS01930	Staphylococcus aureus	84-89
29379887-6	2018	Morphological observations, Oil Red-O staining results, triglyceride content analysis, and quantitative reverse transcription polymerase chain reaction revealed that quercetin was capable of inhibiting the adipogenic induction of muscle satellite cells into adipocytes in a dose-dependent manner by suppressing the transcript levels of adipogenic markers, such as peroxisome proliferator-activated receptor-gamma and fatty acid binding protein 4.	Quercetin	166-175	peroxisome proliferator activated receptor gamma	Homo sapiens	364-412
29379887-6	2018	Morphological observations, Oil Red-O staining results, triglyceride content analysis, and quantitative reverse transcription polymerase chain reaction revealed that quercetin was capable of inhibiting the adipogenic induction of muscle satellite cells into adipocytes in a dose-dependent manner by suppressing the transcript levels of adipogenic markers, such as peroxisome proliferator-activated receptor-gamma and fatty acid binding protein 4.	Quercetin	166-175	fatty acid binding protein 4	Homo sapiens	417-445
29491651-0	2018	Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities.	Quercetin	34-43	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-85
28902451-6	2018	Enzyme activity of UGT76E11 to glucosylate quercetin and other flavonoids was confirmed.	Quercetin	43-52	UDP-glucosyl transferase 76E11	Arabidopsis thaliana	19-27
29317830-0	2018	Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway.	Quercetin	0-9	tumor protein p53	Homo sapiens	120-123
29150398-0	2017	Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.	Quercetin	31-40	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	139-158
29317830-2	2018	However, the role of tumor suppressor p53 on quercetin"s radiosensitization and regulation of endoplasmic reticulum (ER) stress response in this process remains obscure.	Quercetin	45-54	tumor protein p53	Homo sapiens	38-41
29317830-3	2018	Here, quercetin exposure resulted in ER stress, prolonged DNA repair, and the expression of p53 protein; phosphorylation on serine 15 and 20 increased in combination with X-irradiation.	Quercetin	6-15	tumor protein p53	Homo sapiens	92-95
29317830-5	2018	The combination of irradiation and quercetin treatment aggravated DNA damages and caused typical apoptotic cell death; as well the expression of Bax and p21 elevated and the expression of Bcl-2 decreased.	Quercetin	35-44	BCL2 associated X, apoptosis regulator	Homo sapiens	145-148
29317830-5	2018	The combination of irradiation and quercetin treatment aggravated DNA damages and caused typical apoptotic cell death; as well the expression of Bax and p21 elevated and the expression of Bcl-2 decreased.	Quercetin	35-44	H3 histone pseudogene 16	Homo sapiens	153-156
29317830-5	2018	The combination of irradiation and quercetin treatment aggravated DNA damages and caused typical apoptotic cell death; as well the expression of Bax and p21 elevated and the expression of Bcl-2 decreased.	Quercetin	35-44	BCL2 apoptosis regulator	Homo sapiens	188-193
29317830-6	2018	Knocking down of p53 could reverse all the above effects under quercetin in combination with radiation.	Quercetin	63-72	tumor protein p53	Homo sapiens	17-20
29317830-8	2018	In human ovarian cancer xenograft model, combined treatment of quercetin and radiation significantly restrained the growth of tumors, accompanied with the activation of p53, CCAAT/enhancer-binding protein homologous protein, and gamma-H2AX.	Quercetin	63-72	tumor protein p53	Homo sapiens	169-172
29317830-9	2018	Overall, these results indicated that quercetin acted as a promising radiosensitizer through p53-dependent ER stress signals.	Quercetin	38-47	tumor protein p53	Homo sapiens	93-96
29080630-0	2017	Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells.	Quercetin	10-19	erythropoietin	Homo sapiens	43-57
29080630-3	2017	Quercetin has been shown to induce expression of hypoxia-inducible factor, a protein that is known to regulate transcription of the erythropoietin (EPO) gene, and EPO is known to have a cytoprotective effect.	Quercetin	0-9	erythropoietin	Homo sapiens	132-146
29080630-3	2017	Quercetin has been shown to induce expression of hypoxia-inducible factor, a protein that is known to regulate transcription of the erythropoietin (EPO) gene, and EPO is known to have a cytoprotective effect.	Quercetin	0-9	erythropoietin	Homo sapiens	148-151
29080630-4	2017	This study used HepG2 cells to assess whether the cell-protective and/or cytotoxic roles of quercetin are mediated by promotion of EPO production.	Quercetin	92-101	erythropoietin	Homo sapiens	131-134
29080630-5	2017	Increases in the levels of HIF-1alpha protein and EPO mRNA were quercetin concentration-dependent, with significant increases observed from 10 muM quercetin.	Quercetin	64-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
29080630-5	2017	Increases in the levels of HIF-1alpha protein and EPO mRNA were quercetin concentration-dependent, with significant increases observed from 10 muM quercetin.	Quercetin	64-73	erythropoietin	Homo sapiens	50-53
29080630-5	2017	Increases in the levels of HIF-1alpha protein and EPO mRNA were quercetin concentration-dependent, with significant increases observed from 10 muM quercetin.	Quercetin	147-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
29080630-6	2017	Silencing of EPO expression by si-EPO RNA attenuated quercetin-induced cytoprotection against hydrogen peroxide toxicity.	Quercetin	53-62	erythropoietin	Homo sapiens	13-16
29080630-6	2017	Silencing of EPO expression by si-EPO RNA attenuated quercetin-induced cytoprotection against hydrogen peroxide toxicity.	Quercetin	53-62	erythropoietin	Homo sapiens	34-37
29080630-10	2017	However, quercetin"s ability to protect cells from cisplatin-induced apoptosis was eliminated when EPO expression was silenced using si-EPO RNA.	Quercetin	9-18	erythropoietin	Homo sapiens	136-139
29080630-11	2017	Together, these results suggested that quercetin"s cytoprotective effects in HepG2 cells are mediated via EPO production.	Quercetin	39-48	erythropoietin	Homo sapiens	106-109
29080630-8	2017	Specifically, the levels of cleaved caspase-3 and Bax and the rate of cell death increased, and the level of Bcl-2 decreased, in cells treated with 50 muM quercetin.	Quercetin	155-164	BCL2 associated X, apoptosis regulator	Homo sapiens	50-53
29150398-5	2017	Amongst the total of 12 constituents tested, quercetin and glabrol showed inhibition of CYP1B1 in live cell assay with IC50 values of 2.2 and 15 microM, respectively.	Quercetin	45-54	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	88-94
29080630-8	2017	Specifically, the levels of cleaved caspase-3 and Bax and the rate of cell death increased, and the level of Bcl-2 decreased, in cells treated with 50 muM quercetin.	Quercetin	155-164	BCL2 apoptosis regulator	Homo sapiens	109-114
29080630-10	2017	However, quercetin"s ability to protect cells from cisplatin-induced apoptosis was eliminated when EPO expression was silenced using si-EPO RNA.	Quercetin	9-18	erythropoietin	Homo sapiens	99-102
29150398-7	2017	The hydroalcoholic extract of G. glabra and quercetin (4) showed complete reversal of cisplatin resistance in CYP1B1 overexpressing triple negative MDA-MB-468 breast cancer cells.	Quercetin	44-53	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	110-116
29150398-8	2017	The selective inhibition of CYP1B1 by quercetin and glabrol over CYP2 and CYP3 family of enzymes was studied by molecular modeling studies.	Quercetin	38-47	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	28-34
29150398-8	2017	The selective inhibition of CYP1B1 by quercetin and glabrol over CYP2 and CYP3 family of enzymes was studied by molecular modeling studies.	Quercetin	38-47	peptidylprolyl isomerase F	Homo sapiens	74-78
29174851-0	2017	Hepatoprotective effect of quercetin via TRAF6/JNK pathway in acute hepatitis.	Quercetin	27-36	TNF receptor-associated factor 6	Mus musculus	41-46
30263806-0	2018	Quercetin and its metabolites protect hepatocytes against ethanol-induced oxidative stress by activation of Nrf2 and AP-1.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
30263806-0	2018	Quercetin and its metabolites protect hepatocytes against ethanol-induced oxidative stress by activation of Nrf2 and AP-1.	Quercetin	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-121
29237430-0	2017	Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways.	Quercetin	20-29	mitogen-activated protein kinase 8	Homo sapiens	76-79
29237430-0	2017	Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways.	Quercetin	20-29	mitogen-activated protein kinase 14	Homo sapiens	84-87
29174851-0	2017	Hepatoprotective effect of quercetin via TRAF6/JNK pathway in acute hepatitis.	Quercetin	27-36	mitogen-activated protein kinase 8	Mus musculus	47-50
29174851-7	2017	The expression of Bax, Bcl-2, Beclin-1, LC3, P62 and caspase 9 were markedly affected by quercetin pretreatment.	Quercetin	89-98	BCL2-associated X protein	Mus musculus	18-21
29174851-7	2017	The expression of Bax, Bcl-2, Beclin-1, LC3, P62 and caspase 9 were markedly affected by quercetin pretreatment.	Quercetin	89-98	B cell leukemia/lymphoma 2	Mus musculus	23-28
29174851-7	2017	The expression of Bax, Bcl-2, Beclin-1, LC3, P62 and caspase 9 were markedly affected by quercetin pretreatment.	Quercetin	89-98	beclin 1, autophagy related	Mus musculus	30-38
29174851-7	2017	The expression of Bax, Bcl-2, Beclin-1, LC3, P62 and caspase 9 were markedly affected by quercetin pretreatment.	Quercetin	89-98	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	40-43
29174851-7	2017	The expression of Bax, Bcl-2, Beclin-1, LC3, P62 and caspase 9 were markedly affected by quercetin pretreatment.	Quercetin	89-98	nucleoporin 62	Mus musculus	45-48
29174851-7	2017	The expression of Bax, Bcl-2, Beclin-1, LC3, P62 and caspase 9 were markedly affected by quercetin pretreatment.	Quercetin	89-98	caspase 9	Mus musculus	53-62
29174851-8	2017	The expression of TRAF6 and p-JNK were decreased in the quercetin groups.	Quercetin	56-65	TNF receptor-associated factor 6	Mus musculus	18-23
29174851-8	2017	The expression of TRAF6 and p-JNK were decreased in the quercetin groups.	Quercetin	56-65	mitogen-activated protein kinase 8	Mus musculus	30-33
29174851-9	2017	Quercetin attenuated apoptosis and autophagy in ConA-induced autoimmune hepatitis by inhibiting TRAF6/JNK pathway.	Quercetin	0-9	TNF receptor-associated factor 6	Mus musculus	96-101
29174851-9	2017	Quercetin attenuated apoptosis and autophagy in ConA-induced autoimmune hepatitis by inhibiting TRAF6/JNK pathway.	Quercetin	0-9	mitogen-activated protein kinase 8	Mus musculus	102-105
29214656-7	2017	We found that quercetin, kaempferol, and atractylenolide II in MXP were potent NRF2 inducers, which could up-regulate the expression of NRF2 and its downstream enzymes NQO1.	Quercetin	14-23	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
29214656-7	2017	We found that quercetin, kaempferol, and atractylenolide II in MXP were potent NRF2 inducers, which could up-regulate the expression of NRF2 and its downstream enzymes NQO1.	Quercetin	14-23	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
29214656-7	2017	We found that quercetin, kaempferol, and atractylenolide II in MXP were potent NRF2 inducers, which could up-regulate the expression of NRF2 and its downstream enzymes NQO1.	Quercetin	14-23	NAD(P)H quinone dehydrogenase 1	Homo sapiens	168-172
29285143-0	2017	Combination treatment with quercetin and resveratrol attenuates high fat diet-induced obesity and associated inflammation in rats via the AMPKalpha1/SIRT1 signaling pathway.	Quercetin	27-36	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	138-148
28942082-16	2017	CONCLUSION: Administration of 3,5,7,3",4"- Pentahydroxy flavone (i.e. Quercetin (QTN)) isolated from MI-ALC showed significant protection against arsenic-induced oxido-nitrosative stress and myocardial injury via modulation of Nrf2, PPAR-gamma, and apoptosis.	Quercetin	30-63	NFE2 like bZIP transcription factor 2	Rattus norvegicus	227-231
28942082-16	2017	CONCLUSION: Administration of 3,5,7,3",4"- Pentahydroxy flavone (i.e. Quercetin (QTN)) isolated from MI-ALC showed significant protection against arsenic-induced oxido-nitrosative stress and myocardial injury via modulation of Nrf2, PPAR-gamma, and apoptosis.	Quercetin	30-63	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	233-243
28942082-16	2017	CONCLUSION: Administration of 3,5,7,3",4"- Pentahydroxy flavone (i.e. Quercetin (QTN)) isolated from MI-ALC showed significant protection against arsenic-induced oxido-nitrosative stress and myocardial injury via modulation of Nrf2, PPAR-gamma, and apoptosis.	Quercetin	70-79	NFE2 like bZIP transcription factor 2	Rattus norvegicus	227-231
28942082-16	2017	CONCLUSION: Administration of 3,5,7,3",4"- Pentahydroxy flavone (i.e. Quercetin (QTN)) isolated from MI-ALC showed significant protection against arsenic-induced oxido-nitrosative stress and myocardial injury via modulation of Nrf2, PPAR-gamma, and apoptosis.	Quercetin	70-79	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	233-243
28942082-16	2017	CONCLUSION: Administration of 3,5,7,3",4"- Pentahydroxy flavone (i.e. Quercetin (QTN)) isolated from MI-ALC showed significant protection against arsenic-induced oxido-nitrosative stress and myocardial injury via modulation of Nrf2, PPAR-gamma, and apoptosis.	Quercetin	81-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	227-231
28942082-16	2017	CONCLUSION: Administration of 3,5,7,3",4"- Pentahydroxy flavone (i.e. Quercetin (QTN)) isolated from MI-ALC showed significant protection against arsenic-induced oxido-nitrosative stress and myocardial injury via modulation of Nrf2, PPAR-gamma, and apoptosis.	Quercetin	81-84	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	233-243
29285052-7	2017	Subsequent treatment with the HSP70 inhibitor quercetin caused significant decreases in the levels of phosphorylated (p)-p38 mitogen-activated protein kinase (p38 MAPK) and p-extracellular signal-regulated protein kinases (ERK; P&lt;0.05), indicating that ERK/p38 MAPK signaling in AD-related phenotypes may be suppressed by oral administration of GGA.	Quercetin	46-55	heat shock protein 1B	Mus musculus	30-35
29285052-7	2017	Subsequent treatment with the HSP70 inhibitor quercetin caused significant decreases in the levels of phosphorylated (p)-p38 mitogen-activated protein kinase (p38 MAPK) and p-extracellular signal-regulated protein kinases (ERK; P&lt;0.05), indicating that ERK/p38 MAPK signaling in AD-related phenotypes may be suppressed by oral administration of GGA.	Quercetin	46-55	mitogen-activated protein kinase 14	Mus musculus	121-124
29285052-7	2017	Subsequent treatment with the HSP70 inhibitor quercetin caused significant decreases in the levels of phosphorylated (p)-p38 mitogen-activated protein kinase (p38 MAPK) and p-extracellular signal-regulated protein kinases (ERK; P&lt;0.05), indicating that ERK/p38 MAPK signaling in AD-related phenotypes may be suppressed by oral administration of GGA.	Quercetin	46-55	mitogen-activated protein kinase 14	Mus musculus	159-167
29285052-7	2017	Subsequent treatment with the HSP70 inhibitor quercetin caused significant decreases in the levels of phosphorylated (p)-p38 mitogen-activated protein kinase (p38 MAPK) and p-extracellular signal-regulated protein kinases (ERK; P&lt;0.05), indicating that ERK/p38 MAPK signaling in AD-related phenotypes may be suppressed by oral administration of GGA.	Quercetin	46-55	mitogen-activated protein kinase 1	Mus musculus	173-221
29285052-7	2017	Subsequent treatment with the HSP70 inhibitor quercetin caused significant decreases in the levels of phosphorylated (p)-p38 mitogen-activated protein kinase (p38 MAPK) and p-extracellular signal-regulated protein kinases (ERK; P&lt;0.05), indicating that ERK/p38 MAPK signaling in AD-related phenotypes may be suppressed by oral administration of GGA.	Quercetin	46-55	mitogen-activated protein kinase 1	Mus musculus	223-226
29285052-7	2017	Subsequent treatment with the HSP70 inhibitor quercetin caused significant decreases in the levels of phosphorylated (p)-p38 mitogen-activated protein kinase (p38 MAPK) and p-extracellular signal-regulated protein kinases (ERK; P&lt;0.05), indicating that ERK/p38 MAPK signaling in AD-related phenotypes may be suppressed by oral administration of GGA.	Quercetin	46-55	mitogen-activated protein kinase 1	Mus musculus	256-259
29285052-7	2017	Subsequent treatment with the HSP70 inhibitor quercetin caused significant decreases in the levels of phosphorylated (p)-p38 mitogen-activated protein kinase (p38 MAPK) and p-extracellular signal-regulated protein kinases (ERK; P&lt;0.05), indicating that ERK/p38 MAPK signaling in AD-related phenotypes may be suppressed by oral administration of GGA.	Quercetin	46-55	mitogen-activated protein kinase 14	Mus musculus	159-162
29285052-7	2017	Subsequent treatment with the HSP70 inhibitor quercetin caused significant decreases in the levels of phosphorylated (p)-p38 mitogen-activated protein kinase (p38 MAPK) and p-extracellular signal-regulated protein kinases (ERK; P&lt;0.05), indicating that ERK/p38 MAPK signaling in AD-related phenotypes may be suppressed by oral administration of GGA.	Quercetin	46-55	mitogen-activated protein kinase 1	Mus musculus	163-167
29285175-0	2017	Quercetin prevents alcohol-induced liver injury through targeting of PI3K/Akt/nuclear factor-kappaB and STAT3 signaling pathway.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	74-77
29285120-6	2017	Histological examination of lung tissue indicated that inhaled Que reduced hemorrhaging and the infiltration of inflammatory cells, and suppressed the expression of the proinflammatory cytokines transforming growth factor-beta1 and interleukin-6.	Quercetin	63-66	transforming growth factor, beta 1	Rattus norvegicus	195-227
29285120-6	2017	Histological examination of lung tissue indicated that inhaled Que reduced hemorrhaging and the infiltration of inflammatory cells, and suppressed the expression of the proinflammatory cytokines transforming growth factor-beta1 and interleukin-6.	Quercetin	63-66	interleukin 6	Rattus norvegicus	232-245
29285153-0	2017	Effects of quercetin on the expression of MCP-1, MMP-9 and VEGF in rats with diabetic retinopathy.	Quercetin	11-20	C-C motif chemokine ligand 2	Rattus norvegicus	42-47
29285153-0	2017	Effects of quercetin on the expression of MCP-1, MMP-9 and VEGF in rats with diabetic retinopathy.	Quercetin	11-20	matrix metallopeptidase 9	Rattus norvegicus	49-54
29285153-0	2017	Effects of quercetin on the expression of MCP-1, MMP-9 and VEGF in rats with diabetic retinopathy.	Quercetin	11-20	vascular endothelial growth factor A	Rattus norvegicus	59-63
29285153-10	2017	No significant difference in serum MCP-1 content was found between the model group and the quercetin group, but levels of MMP-9 and VEGF were significantly decreased in the quercetin group (P&lt;0.01).	Quercetin	173-182	matrix metallopeptidase 9	Rattus norvegicus	122-127
29285153-10	2017	No significant difference in serum MCP-1 content was found between the model group and the quercetin group, but levels of MMP-9 and VEGF were significantly decreased in the quercetin group (P&lt;0.01).	Quercetin	173-182	vascular endothelial growth factor A	Rattus norvegicus	132-136
29285153-12	2017	No significant differences in expression levels of MCP-1 mRNA and protein were found between the model group and the quercetin group, but levels of MMP-9 and VEGF mRNA and protein were significantly decreased in the quercetin group (P&lt;0.01).	Quercetin	216-225	matrix metallopeptidase 9	Rattus norvegicus	148-153
29285153-12	2017	No significant differences in expression levels of MCP-1 mRNA and protein were found between the model group and the quercetin group, but levels of MMP-9 and VEGF mRNA and protein were significantly decreased in the quercetin group (P&lt;0.01).	Quercetin	216-225	vascular endothelial growth factor A	Rattus norvegicus	158-162
29285153-13	2017	Quercetin has a certain therapeutic effect on rats with diabetic retinopathy and its effect may be achieved by reducing the expression of MMP-9 and VEGF, but not the inflammatory mediator, MCP-1.	Quercetin	0-9	matrix metallopeptidase 9	Rattus norvegicus	138-143
29285153-13	2017	Quercetin has a certain therapeutic effect on rats with diabetic retinopathy and its effect may be achieved by reducing the expression of MMP-9 and VEGF, but not the inflammatory mediator, MCP-1.	Quercetin	0-9	vascular endothelial growth factor A	Rattus norvegicus	148-152
29285153-13	2017	Quercetin has a certain therapeutic effect on rats with diabetic retinopathy and its effect may be achieved by reducing the expression of MMP-9 and VEGF, but not the inflammatory mediator, MCP-1.	Quercetin	0-9	C-C motif chemokine ligand 2	Rattus norvegicus	189-194
29285175-0	2017	Quercetin prevents alcohol-induced liver injury through targeting of PI3K/Akt/nuclear factor-kappaB and STAT3 signaling pathway.	Quercetin	0-9	signal transducer and activator of transcription 3	Mus musculus	104-109
29285175-5	2017	Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-kappaB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice.	Quercetin	0-9	B cell leukemia/lymphoma 2	Mus musculus	67-90
29285175-5	2017	Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-kappaB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice.	Quercetin	0-9	B cell leukemia/lymphoma 2	Mus musculus	92-97
29285175-5	2017	Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-kappaB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice.	Quercetin	0-9	caspase 3	Mus musculus	132-141
29285175-5	2017	Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-kappaB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice.	Quercetin	0-9	poly (ADP-ribose) polymerase family, member 1	Mus musculus	143-169
29285175-5	2017	Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-kappaB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	250-276
29285143-0	2017	Combination treatment with quercetin and resveratrol attenuates high fat diet-induced obesity and associated inflammation in rats via the AMPKalpha1/SIRT1 signaling pathway.	Quercetin	27-36	sirtuin 1	Rattus norvegicus	149-154
29285175-5	2017	Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-kappaB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	299-302
29285175-6	2017	These results suggested that the protective role of quercetin prevents alcohol-induced liver injury through the phosphoinositide 3-kinase/Akt/NF-kappaB and STAT3 pathway.	Quercetin	52-61	thymoma viral proto-oncogene 1	Mus musculus	138-141
29285175-6	2017	These results suggested that the protective role of quercetin prevents alcohol-induced liver injury through the phosphoinositide 3-kinase/Akt/NF-kappaB and STAT3 pathway.	Quercetin	52-61	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
28970059-2	2017	We reported previously that the flavonoid quercetin protects arteries from oxidant-induced endothelial dysfunction and attenuates atherosclerosis in apolipoprotein E gene knockout mice, with induction of heme oxygenase-1 (Hmox1) playing a critical role.	Quercetin	42-51	apolipoprotein E	Mus musculus	149-165
29285175-6	2017	These results suggested that the protective role of quercetin prevents alcohol-induced liver injury through the phosphoinositide 3-kinase/Akt/NF-kappaB and STAT3 pathway.	Quercetin	52-61	signal transducer and activator of transcription 3	Mus musculus	156-161
28970059-2	2017	We reported previously that the flavonoid quercetin protects arteries from oxidant-induced endothelial dysfunction and attenuates atherosclerosis in apolipoprotein E gene knockout mice, with induction of heme oxygenase-1 (Hmox1) playing a critical role.	Quercetin	42-51	heme oxygenase 1	Mus musculus	222-227
28970059-2	2017	We reported previously that the flavonoid quercetin protects arteries from oxidant-induced endothelial dysfunction and attenuates atherosclerosis in apolipoprotein E gene knockout mice, with induction of heme oxygenase-1 (Hmox1) playing a critical role.	Quercetin	42-51	heme oxygenase 1	Mus musculus	204-220
29040945-0	2017	Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-kappaB pathway.	Quercetin	0-9	hepatitis A virus cellular receptor 2	Mus musculus	112-117
29040945-0	2017	Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-kappaB pathway.	Quercetin	0-9	toll-like receptor 4	Mus musculus	122-126
29040945-0	2017	Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-kappaB pathway.	Quercetin	0-9	myeloid differentiation primary response gene 88	Mus musculus	127-132
29040945-0	2017	Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-kappaB pathway.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	133-142
29399028-0	2017	Quercetin attenuates the injury-induced reduction of gamma-enolase expression in a middle cerebral artery occlusion animal model.	Quercetin	0-9	enolase 2	Rattus norvegicus	53-66
28872689-5	2017	METHODS: Two flavonoids, luteolin and quercetin, were evaluated as potential inhibitors of eight human CYP isoforms, of six UDP-glucuronosyltransferase (UGT) isoforms and of APAP glucuronidation and sulfation.	Quercetin	38-47	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-106
28872689-5	2017	METHODS: Two flavonoids, luteolin and quercetin, were evaluated as potential inhibitors of eight human CYP isoforms, of six UDP-glucuronosyltransferase (UGT) isoforms and of APAP glucuronidation and sulfation.	Quercetin	38-47	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	124-151
28872689-5	2017	METHODS: Two flavonoids, luteolin and quercetin, were evaluated as potential inhibitors of eight human CYP isoforms, of six UDP-glucuronosyltransferase (UGT) isoforms and of APAP glucuronidation and sulfation.	Quercetin	38-47	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	153-156
28872689-7	2017	KEY FINDINGS: Luteolin and quercetin inhibited human CYP isoforms to varying degrees, with greatest potency towards CYP1A2 and CYP2C8.	Quercetin	27-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	53-56
28872689-7	2017	KEY FINDINGS: Luteolin and quercetin inhibited human CYP isoforms to varying degrees, with greatest potency towards CYP1A2 and CYP2C8.	Quercetin	27-36	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	116-122
28872689-7	2017	KEY FINDINGS: Luteolin and quercetin inhibited human CYP isoforms to varying degrees, with greatest potency towards CYP1A2 and CYP2C8.	Quercetin	27-36	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	127-133
28872689-11	2017	CONCLUSIONS: Inhibition of human CYP activity by luteolin and quercetin occurred with IC50 values exceeding customary in-vivo human exposure with tolerable supplemental doses of these compounds.	Quercetin	62-71	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-36
28958213-0	2017	Ligand-based virtual screening, molecular docking, QSAR and pharmacophore analysis of quercetin-associated potential novel analogs against epidermal growth factor receptor.	Quercetin	86-95	epidermal growth factor receptor	Homo sapiens	139-171
28958213-1	2017	The present study was to explore expectation and examination of therapeutic potential quercetin analogs as efficient anticancer agents against human epidermal growth factor receptor (EGFR), which is a consistent hallmark for moderating the non-small-cell lung carcinoma (NSCLC).	Quercetin	86-95	epidermal growth factor receptor	Homo sapiens	149-181
28958213-1	2017	The present study was to explore expectation and examination of therapeutic potential quercetin analogs as efficient anticancer agents against human epidermal growth factor receptor (EGFR), which is a consistent hallmark for moderating the non-small-cell lung carcinoma (NSCLC).	Quercetin	86-95	epidermal growth factor receptor	Homo sapiens	183-187
29399028-4	2017	The aim of the present study is to verify whether quercetin modulates the expression of gamma-enolase in brain ischemic injury.	Quercetin	50-59	enolase 2	Rattus norvegicus	88-101
29399028-10	2017	gamma-Enolase is accepted as a neuron specific energy synthesis enzyme, and quercetin modulates gamma-enolase in a MCAO animal model.	Quercetin	76-85	enolase 2	Rattus norvegicus	96-109
29399028-11	2017	Thus, our findings can suggest the possibility that quercetin regulates gamma-enolase expression in response to cerebral ischemia, which likely contributes to the neuroprotective effect of quercetin.	Quercetin	52-61	enolase 2	Rattus norvegicus	72-85
29399028-11	2017	Thus, our findings can suggest the possibility that quercetin regulates gamma-enolase expression in response to cerebral ischemia, which likely contributes to the neuroprotective effect of quercetin.	Quercetin	189-198	enolase 2	Rattus norvegicus	72-85
29165402-0	2017	Quercetin Mitigates Inflammatory Responses Induced by Vascular Endothelial Growth Factor in Mouse Retinal Photoreceptor Cells through Suppression of Nuclear Factor Kappa B.	Quercetin	0-9	vascular endothelial growth factor A	Mus musculus	54-88
28729398-8	2017	Our results indicate that quercetin downregulates hnRNPA1 expression, downregulates the expression of AR-V7, antagonizes androgen receptor signaling, and resensitizes enzalutamide-resistant prostate cancer cells to enzalutamide treatment in vivo in mouse xenografts.	Quercetin	26-35	androgen receptor	Mus musculus	121-138
29132096-0	2017	Quercetin prevents type 1 diabetic liver damage through inhibition of CYP2E1.	Quercetin	0-9	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	70-76
29132096-2	2017	In this work we investigated the quercetin properties to prevent diabetic oxidative liver injury through inhibition of CYP2E1.	Quercetin	33-42	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	119-125
29132096-7	2017	We demonstrated that the administration of quercetin leads to significant decrease in CYP2E1 activity (5- and 2-times compared to STZ-diabetic and control group, respectively).	Quercetin	43-52	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	86-92
29132096-9	2017	CONCLUSIONS: CYP2E1 can play a crucial role in stress-induced pathological processes in the liver in diabetes, and the inhibition of the enzyme by quercetin during the development of diabetes mainly prevents the oxidative damage in liver.	Quercetin	147-156	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	13-19
28729398-0	2017	Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells.	Quercetin	0-9	heterogeneous nuclear ribonucleoprotein A1	Mus musculus	18-25
28729398-6	2017	In the present study, we discovered that quercetin, a naturally occurring polyphenolic compound, reduces the expression of hnRNPA1, and consequently, that of AR-V7.	Quercetin	41-50	heterogeneous nuclear ribonucleoprotein A1	Mus musculus	123-130
28729398-8	2017	Our results indicate that quercetin downregulates hnRNPA1 expression, downregulates the expression of AR-V7, antagonizes androgen receptor signaling, and resensitizes enzalutamide-resistant prostate cancer cells to enzalutamide treatment in vivo in mouse xenografts.	Quercetin	26-35	heterogeneous nuclear ribonucleoprotein A1	Mus musculus	50-57
28939429-11	2017	Quercetin treatment significantly lowered insulin and IR expression and significantly enhanced GLUT-4 and DCX expression in the hippocampus, when compared to CUS.	Quercetin	0-9	insulin receptor	Mus musculus	54-56
28939429-11	2017	Quercetin treatment significantly lowered insulin and IR expression and significantly enhanced GLUT-4 and DCX expression in the hippocampus, when compared to CUS.	Quercetin	0-9	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	95-101
28939429-11	2017	Quercetin treatment significantly lowered insulin and IR expression and significantly enhanced GLUT-4 and DCX expression in the hippocampus, when compared to CUS.	Quercetin	0-9	doublecortin	Mus musculus	106-109
28987380-7	2017	Ex vivo incubation with quercetin in blood of both IPF patients and healthy controls reduces LPS-induced production of the pro-inflammatory cytokines IL-8 and TNFalpha.	Quercetin	24-33	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
28987380-7	2017	Ex vivo incubation with quercetin in blood of both IPF patients and healthy controls reduces LPS-induced production of the pro-inflammatory cytokines IL-8 and TNFalpha.	Quercetin	24-33	tumor necrosis factor	Homo sapiens	159-167
28987380-9	2017	Our pro-fibrotic in vitro model, consisting of bleomycin-triggered BEAS-2B cells, shows that quercetin boosts the antioxidant response, by increasing Nrf2 activity, and decreases pro-inflammatory cytokine production in a concentration-dependent manner.	Quercetin	93-102	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
29230177-12	2017	Treatment with quercetin, one bioactive ingredient in Noni, up-regulated the expression of ACCalpha, FASN, and ACLY under TN conditions, but it appeared to down-regulate ACCalpha and increase ACLY levels under HS exposure.	Quercetin	15-24	fatty acid synthase	Gallus gallus	101-105
29230177-12	2017	Treatment with quercetin, one bioactive ingredient in Noni, up-regulated the expression of ACCalpha, FASN, and ACLY under TN conditions, but it appeared to down-regulate ACCalpha and increase ACLY levels under HS exposure.	Quercetin	15-24	ATP citrate lyase	Gallus gallus	111-115
29230177-12	2017	Treatment with quercetin, one bioactive ingredient in Noni, up-regulated the expression of ACCalpha, FASN, and ACLY under TN conditions, but it appeared to down-regulate ACCalpha and increase ACLY levels under HS exposure.	Quercetin	15-24	ATP citrate lyase	Gallus gallus	192-196
29165402-0	2017	Quercetin Mitigates Inflammatory Responses Induced by Vascular Endothelial Growth Factor in Mouse Retinal Photoreceptor Cells through Suppression of Nuclear Factor Kappa B.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-171
29165402-3	2017	The aims of this study are to demonstrate the inflammatory protein expression regulated by VEGF using mouse photoreceptor-derived cells and the protective effect of quercetin against VEGF-induced inflammatory response.	Quercetin	165-174	vascular endothelial growth factor A	Mus musculus	183-187
29165402-9	2017	Zona occludins-1 and beta-catenin decreased by VEGF were recovered by quercetin.	Quercetin	70-79	catenin (cadherin associated protein), beta 1	Mus musculus	21-33
29165402-9	2017	Zona occludins-1 and beta-catenin decreased by VEGF were recovered by quercetin.	Quercetin	70-79	vascular endothelial growth factor A	Mus musculus	47-51
29165402-10	2017	NF-kappaB signaling pathway regulated by VEGF through phosphorylations of mitogen-activated protein kinases (MAPK) and protein kinase B (Akt) was suppressed by quercetin.	Quercetin	160-169	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
29165402-10	2017	NF-kappaB signaling pathway regulated by VEGF through phosphorylations of mitogen-activated protein kinases (MAPK) and protein kinase B (Akt) was suppressed by quercetin.	Quercetin	160-169	vascular endothelial growth factor A	Mus musculus	41-45
29165402-10	2017	NF-kappaB signaling pathway regulated by VEGF through phosphorylations of mitogen-activated protein kinases (MAPK) and protein kinase B (Akt) was suppressed by quercetin.	Quercetin	160-169	thymoma viral proto-oncogene 1	Mus musculus	137-140
29165402-11	2017	These results suggest that quercetin suppressed VEGF-induced excessive inflammatory response in retinal photoreceptor cells by inactivation of NF-kappaB signals through inhibition of MAPKs and Akt.	Quercetin	27-36	vascular endothelial growth factor A	Mus musculus	48-52
29201361-0	2017	Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	97-106
29165402-11	2017	These results suggest that quercetin suppressed VEGF-induced excessive inflammatory response in retinal photoreceptor cells by inactivation of NF-kappaB signals through inhibition of MAPKs and Akt.	Quercetin	27-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
29201361-8	2017	Quercetin infusion ameliorated AMPA-induced paralysis, rescued motor neurons, and prevented both astrogliosis and microgliosis, and these protective effects were prevented by EX527, a very selective SIRT1 inhibitor.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	199-204
29201361-10	2017	Conclusions: These results suggest that quercetin exerts its beneficial effects through a SIRT1-mediated mechanism, and thus SIRT1 plays an important role in excitotoxic neurodegeneration and therefore its pharmacological modulation might provide opportunities for therapy in motor neuron disorders.	Quercetin	40-49	sirtuin 1	Rattus norvegicus	90-95
29165402-11	2017	These results suggest that quercetin suppressed VEGF-induced excessive inflammatory response in retinal photoreceptor cells by inactivation of NF-kappaB signals through inhibition of MAPKs and Akt.	Quercetin	27-36	thymoma viral proto-oncogene 1	Mus musculus	193-196
29201361-10	2017	Conclusions: These results suggest that quercetin exerts its beneficial effects through a SIRT1-mediated mechanism, and thus SIRT1 plays an important role in excitotoxic neurodegeneration and therefore its pharmacological modulation might provide opportunities for therapy in motor neuron disorders.	Quercetin	40-49	sirtuin 1	Rattus norvegicus	125-130
29371942-0	2017	Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.	Quercetin	8-17	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	179-183
29371942-3	2017	Using an in vitro screening assay for new inhibitors of SHP2 phosphatase, we found that quercetin was a potent inhibitor of SHP2.	Quercetin	88-97	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	56-60
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	192-201	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	22-26
29371942-3	2017	Using an in vitro screening assay for new inhibitors of SHP2 phosphatase, we found that quercetin was a potent inhibitor of SHP2.	Quercetin	88-97	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	124-128
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	192-201	interferon alpha 1	Homo sapiens	65-74
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	192-201	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	164-168
29371942-4	2017	Computational modeling showed that quercetin exhibited an orientation favorable to nucleophilic attack in the phosphatase domain of SHP2.	Quercetin	35-44	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	132-136
29371942-5	2017	Quercetin enhanced the phosphorylation of signal transducer and activator of transcription proteins 1 (STAT1) and promoted endogenous IFN-alpha-regulated gene expression.	Quercetin	0-9	signal transducer and activator of transcription 1	Homo sapiens	42-101
29371942-8	2017	The results suggested that quercetin potentiated the inhibitory effect of IFN-alpha on cancer cell proliferation through activation of JAK/STAT pathway signaling by inhibiting SHP2.	Quercetin	27-36	interferon alpha 1	Homo sapiens	74-83
29371942-8	2017	The results suggested that quercetin potentiated the inhibitory effect of IFN-alpha on cancer cell proliferation through activation of JAK/STAT pathway signaling by inhibiting SHP2.	Quercetin	27-36	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	176-180
29371942-5	2017	Quercetin enhanced the phosphorylation of signal transducer and activator of transcription proteins 1 (STAT1) and promoted endogenous IFN-alpha-regulated gene expression.	Quercetin	0-9	signal transducer and activator of transcription 1	Homo sapiens	103-108
29371942-9	2017	Quercetin warrants further investigation as a novel therapeutic method to enhance the efficacy of IFN-alpha/beta.	Quercetin	0-9	interferon alpha 1	Homo sapiens	98-107
29371942-5	2017	Quercetin enhanced the phosphorylation of signal transducer and activator of transcription proteins 1 (STAT1) and promoted endogenous IFN-alpha-regulated gene expression.	Quercetin	0-9	interferon alpha 1	Homo sapiens	134-143
29371942-6	2017	Furthermore, quercetin also sensitized the antiproliferative effect of IFN-alpha on hepatocellular carcinoma HepG2 and Huh7 cells.	Quercetin	13-22	interferon alpha 1	Homo sapiens	71-80
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	52-61	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	22-26
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	52-61	interferon alpha 1	Homo sapiens	65-74
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	52-61	signal transducer and activator of transcription 1	Homo sapiens	86-91
28858733-0	2017	Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	54-59
28858733-0	2017	Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa.	Quercetin	0-9	myeloperoxidase	Rattus norvegicus	64-67
28858733-5	2017	In acute phase, 4h after start of reperfusion, the quercetin induced a significant decrease in mucosal injury index (p&lt;0.05) accompanied by a significant decrease in cyclooxygenase-2 (COX-2) expression in the epithelial lining of the intestinal villi in comparison with the control group (p&lt;0.01).	Quercetin	51-60	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	169-185
28858733-5	2017	In acute phase, 4h after start of reperfusion, the quercetin induced a significant decrease in mucosal injury index (p&lt;0.05) accompanied by a significant decrease in cyclooxygenase-2 (COX-2) expression in the epithelial lining of the intestinal villi in comparison with the control group (p&lt;0.01).	Quercetin	51-60	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	187-192
28938515-8	2017	In addition, HMG-CoA reductase activity was decreased in quercetin groups and this confirmed in gene expression that these groups caused downregulation for HMG-CoA reductase.	Quercetin	57-66	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	13-30
28938515-8	2017	In addition, HMG-CoA reductase activity was decreased in quercetin groups and this confirmed in gene expression that these groups caused downregulation for HMG-CoA reductase.	Quercetin	57-66	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	156-173
28858733-6	2017	In the epithelium of the intestinal glands, COX-2 expression resulting from IR injury significantly increased regardless quercetin application (in control group p&lt;0.001; in quercetin group p&lt;0.05), but in quercetin group, significant decrease in it during 24h of reperfusion in a late phase of IR injury was detected (p&lt;0.001).	Quercetin	121-130	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	44-49
28858733-6	2017	In the epithelium of the intestinal glands, COX-2 expression resulting from IR injury significantly increased regardless quercetin application (in control group p&lt;0.001; in quercetin group p&lt;0.05), but in quercetin group, significant decrease in it during 24h of reperfusion in a late phase of IR injury was detected (p&lt;0.001).	Quercetin	176-185	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	44-49
28938515-9	2017	However, LDL receptor (LDLr) gene expression was upregulated by quercetin.	Quercetin	64-73	low density lipoprotein receptor	Rattus norvegicus	9-21
28938515-9	2017	However, LDL receptor (LDLr) gene expression was upregulated by quercetin.	Quercetin	64-73	low density lipoprotein receptor	Rattus norvegicus	23-27
28858733-6	2017	In the epithelium of the intestinal glands, COX-2 expression resulting from IR injury significantly increased regardless quercetin application (in control group p&lt;0.001; in quercetin group p&lt;0.05), but in quercetin group, significant decrease in it during 24h of reperfusion in a late phase of IR injury was detected (p&lt;0.001).	Quercetin	176-185	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	44-49
28663152-5	2017	Inhibition of pure and cellular catalase from K562 cells by flavonoids was similar and exhibited the following efficacy; Myrecetin&gt;Quercetin&gt;Kaempferol and Quercetin&gt;Luteolin&gt;Apigenin demonstrating structure activity relationship.	Quercetin	134-143	catalase	Homo sapiens	32-40
28963941-0	2017	Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-kappaB and MAPK signal pathways.	Quercetin	27-36	toll-like receptor 4	Mus musculus	45-48
28963941-0	2017	Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-kappaB and MAPK signal pathways.	Quercetin	27-36	galanin and GMAP prepropeptide	Mus musculus	51-55
28963941-0	2017	Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-kappaB and MAPK signal pathways.	Quercetin	27-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
28963941-2	2017	However, the underlying mechanism of how quercetin to protect against lipopolysaccharides/d-galactosamine (LPS/d-GalN) induced acute liver injury remains unclear.	Quercetin	41-50	toll-like receptor 4	Mus musculus	107-110
28663152-5	2017	Inhibition of pure and cellular catalase from K562 cells by flavonoids was similar and exhibited the following efficacy; Myrecetin&gt;Quercetin&gt;Kaempferol and Quercetin&gt;Luteolin&gt;Apigenin demonstrating structure activity relationship.	Quercetin	162-171	catalase	Homo sapiens	32-40
28963941-2	2017	However, the underlying mechanism of how quercetin to protect against lipopolysaccharides/d-galactosamine (LPS/d-GalN) induced acute liver injury remains unclear.	Quercetin	41-50	galanin and GMAP prepropeptide	Mus musculus	113-117
28513070-0	2017	Influence of quercetin on the interaction of gliclazide with human serum albumin - spectroscopic and docking approaches.	Quercetin	13-22	albumin	Homo sapiens	67-80
28513070-2	2017	Thus, the aim of presented study was to analyse human serum albumin-binding displacement interaction between two ligands, hypoglycaemic drug gliclazide and widely distributed plant flavonoid quercetin.	Quercetin	191-200	albumin	Homo sapiens	54-67
28513070-7	2017	Results also showed that the presence of quercetin hindered the interaction between HSA and gliclazide, as the binding constant for gliclazide in the ternary system was remarkably lower compared with the binary system.	Quercetin	41-50	albumin	Homo sapiens	84-87
29023372-2	2017	Quercetin and its glycosides have PARP inhibitory effects and can induce selective cytotoxicity in BRCA2-deficient cells by synthetic lethality.	Quercetin	0-9	poly [ADP-ribose] polymerase 1	Cricetulus griseus	34-38
27796749-0	2017	Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Abeta Aggregates in Hippocampal Neurons: the Role of Mitochondria.	Quercetin	0-9	amyloid beta precursor protein	Rattus norvegicus	71-76
27796749-6	2017	Our results indicate that quercetin efficiently protected against H2O2-induced neuronal toxicity; however, this protection was only partial in rat hippocampal neurons that were treated with Abeta.	Quercetin	26-35	amyloid beta precursor protein	Rattus norvegicus	190-195
27796749-8	2017	By contrast, quercetin treatment partially rescued hippocampal neurons from Abeta-induced mitochondrial injury.	Quercetin	13-22	amyloid beta precursor protein	Rattus norvegicus	76-81
27796749-9	2017	Most importantly, quercetin treatment prevented the toxic effects that are induced by H2O2 in hippocampal neurons and, to a lesser extent, the Abeta-induced toxicity that is associated with the superoxide anion, which is a precursor of ROS production in mitochondria.	Quercetin	18-27	amyloid beta precursor protein	Rattus norvegicus	143-148
27796749-10	2017	Collectively, these results indicate that quercetin exerts differential effects on the prevention of H2O2- and Abeta-induced neurotoxicity in hippocampal neurons and may be a powerful tool for dissecting the molecular mechanisms underlying Abeta neurotoxicity.	Quercetin	42-51	amyloid beta precursor protein	Rattus norvegicus	111-116
29123394-0	2017	Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium.	Quercetin	0-9	intercellular adhesion molecule 1	Rattus norvegicus	102-108
29123394-1	2017	The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE.	Quercetin	65-74	intercellular adhesion molecule 1	Rattus norvegicus	163-197
29123394-1	2017	The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE.	Quercetin	65-74	intercellular adhesion molecule 1	Rattus norvegicus	199-205
29123394-1	2017	The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE.	Quercetin	76-79	intercellular adhesion molecule 1	Rattus norvegicus	163-197
29123394-1	2017	The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE.	Quercetin	76-79	intercellular adhesion molecule 1	Rattus norvegicus	199-205
29123394-4	2017	Both QUE and QUE nanoparticle complex preconditioning ameliorated the pathological damage of kidney and improved renal function, alleviated renal oxidative stress injury, restricted inflammatory cells infiltration, and downregulated the ICAM-1 expression as compared to DN group, while QUE nanoparticle complex significantly alleviated this effect.	Quercetin	5-8	intercellular adhesion molecule 1	Rattus norvegicus	237-243
29123394-4	2017	Both QUE and QUE nanoparticle complex preconditioning ameliorated the pathological damage of kidney and improved renal function, alleviated renal oxidative stress injury, restricted inflammatory cells infiltration, and downregulated the ICAM-1 expression as compared to DN group, while QUE nanoparticle complex significantly alleviated this effect.	Quercetin	13-16	intercellular adhesion molecule 1	Rattus norvegicus	237-243
29123394-4	2017	Both QUE and QUE nanoparticle complex preconditioning ameliorated the pathological damage of kidney and improved renal function, alleviated renal oxidative stress injury, restricted inflammatory cells infiltration, and downregulated the ICAM-1 expression as compared to DN group, while QUE nanoparticle complex significantly alleviated this effect.	Quercetin	13-16	intercellular adhesion molecule 1	Rattus norvegicus	237-243
29023372-2	2017	Quercetin and its glycosides have PARP inhibitory effects and can induce selective cytotoxicity in BRCA2-deficient cells by synthetic lethality.	Quercetin	0-9	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	99-104
29023372-3	2017	We hypothesized that common flavonoids in diet naringenin, hesperetin and their glycosides have a similar structure to quercetin, which might have comparable PARP inhibitory effects, and can induce selective cytotoxicity in BRCA2-deficient cells.	Quercetin	119-128	poly [ADP-ribose] polymerase 1	Cricetulus griseus	158-162
29023372-3	2017	We hypothesized that common flavonoids in diet naringenin, hesperetin and their glycosides have a similar structure to quercetin, which might have comparable PARP inhibitory effects, and can induce selective cytotoxicity in BRCA2-deficient cells.	Quercetin	119-128	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	224-229
29023372-8	2017	Quercetin and naringenin killed V-C8 cells with lower concentrations, and presented selective cytotoxicity to BRCA2-deficient cells.	Quercetin	0-9	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	110-115
28676971-6	2017	Elevated ROS also increased the expression of COX-2 and APE1 enzymes and pretreatment of Curcumin and Quercetin decreased COX-2 expression and increased APE1 expression in the oxidatively stressed U-87 MG cells.	Quercetin	102-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
28648644-0	2017	Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways.	Quercetin	0-9	snail family transcriptional repressor 1	Homo sapiens	78-83
28648644-0	2017	Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	94-97
28648644-0	2017	Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways.	Quercetin	0-9	snail family transcriptional repressor 1	Homo sapiens	113-118
28648644-0	2017	Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways.	Quercetin	0-9	ADAM metallopeptidase domain 9	Homo sapiens	131-136
28648644-3	2017	Herein, we found that quercetin inhibited the migration/invasion of non-small cell lung cancer (NSCLC) cell lines and bone metastasis in an orthotopic A549 xenograft model by suppressing the Snail-mediated epithelial-to-mesenchymal transition (EMT).	Quercetin	22-31	snail family transcriptional repressor 1	Homo sapiens	191-196
28648644-5	2017	Mechanistic investigations found that quercetin suppressed Snail-dependent Akt activation by upregulating maspin and Snail-independent a disintegrin and metalloproteinase (ADAM) 9 expression pathways to modulate the invasive ability of NSCLC cells.	Quercetin	38-47	snail family transcriptional repressor 1	Homo sapiens	59-64
28648644-5	2017	Mechanistic investigations found that quercetin suppressed Snail-dependent Akt activation by upregulating maspin and Snail-independent a disintegrin and metalloproteinase (ADAM) 9 expression pathways to modulate the invasive ability of NSCLC cells.	Quercetin	38-47	AKT serine/threonine kinase 1	Homo sapiens	75-78
28648644-5	2017	Mechanistic investigations found that quercetin suppressed Snail-dependent Akt activation by upregulating maspin and Snail-independent a disintegrin and metalloproteinase (ADAM) 9 expression pathways to modulate the invasive ability of NSCLC cells.	Quercetin	38-47	serpin family B member 5	Homo sapiens	106-112
28648644-5	2017	Mechanistic investigations found that quercetin suppressed Snail-dependent Akt activation by upregulating maspin and Snail-independent a disintegrin and metalloproteinase (ADAM) 9 expression pathways to modulate the invasive ability of NSCLC cells.	Quercetin	38-47	snail family transcriptional repressor 1	Homo sapiens	117-122
29064290-0	2017	Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators.	Quercetin	0-9	insulin	Homo sapiens	72-79
29064290-2	2017	RESULTS: Starting from quercetin and oleic acid, that have effect on insulin secretion, a small set of hybrid molecules was synthesized.	Quercetin	23-32	insulin	Homo sapiens	69-76
28504248-2	2017	In the current study, we characterized TL-2-8, a quercetin derivative, as a novel anticancer agent in vitro and in vivo.	Quercetin	49-58	TNF superfamily member 10	Homo sapiens	39-45
28783583-3	2017	Amongst the bioactives tested, quercetin was more potent and restored LRP1 and brain insulin signalling components as well as glucose transporters such as GLUTs 1, 2, 3 and 4 in diabetic animals.	Quercetin	31-40	LDL receptor related protein 1	Rattus norvegicus	70-74
28783583-3	2017	Amongst the bioactives tested, quercetin was more potent and restored LRP1 and brain insulin signalling components as well as glucose transporters such as GLUTs 1, 2, 3 and 4 in diabetic animals.	Quercetin	31-40	solute carrier family 2 member 1	Rattus norvegicus	155-174
28787700-12	2017	Moreover, luciferase assay in HEK293 cells showed that QUE dose-dependently inhibited NF-kappaB activity only via TAK1.	Quercetin	55-58	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	114-118
28873682-0	2017	Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism.	Quercetin	0-9	tyrosinase	Homo sapiens	15-25
28873682-1	2017	Quercetin, a flavonoid compound, was found to inhibit both monophenolase and diphenolase activities of tyrosinase, and its inhibition against diphenolase activity was in a reversible and competitive manner with an IC50 value of (3.08+-0.74)x10-5molL-1.	Quercetin	0-9	tyrosinase	Homo sapiens	103-113
28873682-2	2017	Quercetin bound to tyrosinase driven by hydrophobic interaction, thereby resulted in a conformational change of tyrosinase and its intrinsic fluorescence quenching.	Quercetin	0-9	tyrosinase	Homo sapiens	19-29
28873682-2	2017	Quercetin bound to tyrosinase driven by hydrophobic interaction, thereby resulted in a conformational change of tyrosinase and its intrinsic fluorescence quenching.	Quercetin	0-9	tyrosinase	Homo sapiens	112-122
28873682-3	2017	Tyrosinase had one binding site for quercetin with the binding constant in the order of magnitude of 104Lmol-1.	Quercetin	36-45	tyrosinase	Homo sapiens	0-10
28873682-6	2017	These findings may be helpful to understand the inhibition mechanism of quercetin on tyrosinase and functional research of quercetin in the treatment of pigmentation disorders.	Quercetin	72-81	tyrosinase	Homo sapiens	85-95
28676971-6	2017	Elevated ROS also increased the expression of COX-2 and APE1 enzymes and pretreatment of Curcumin and Quercetin decreased COX-2 expression and increased APE1 expression in the oxidatively stressed U-87 MG cells.	Quercetin	102-111	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	153-157
28849202-6	2017	After 3 weeks of drug treatment, the potential ability of quercetin to improve the generalized hyperalgesia in mice with induced adenomyosis was evaluated by determining the body weight, pain modulation, examining the myometrial infiltration by histology examination of the uterus and detecting the expression of transient receptor potential cation channel subfamily V member 1 (Trpv-1), phospho (p)-p38 mitogen activated protein kinase p-extracellular signal-regulated kinase (p-ERK) in DRG neurons via immunohistochemistry.	Quercetin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	313-377
28849202-6	2017	After 3 weeks of drug treatment, the potential ability of quercetin to improve the generalized hyperalgesia in mice with induced adenomyosis was evaluated by determining the body weight, pain modulation, examining the myometrial infiltration by histology examination of the uterus and detecting the expression of transient receptor potential cation channel subfamily V member 1 (Trpv-1), phospho (p)-p38 mitogen activated protein kinase p-extracellular signal-regulated kinase (p-ERK) in DRG neurons via immunohistochemistry.	Quercetin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	379-385
28668616-7	2017	Low levels of quercetin, myricetin and pentaacetylquercetin (10muM) stimulated cAMP-dependent Star, Cyp11a1 and Fdx1 promoters" activations and may increase steroidogenesis within Leydig cells.	Quercetin	14-23	steroidogenic acute regulatory protein	Mus musculus	94-98
28849202-6	2017	After 3 weeks of drug treatment, the potential ability of quercetin to improve the generalized hyperalgesia in mice with induced adenomyosis was evaluated by determining the body weight, pain modulation, examining the myometrial infiltration by histology examination of the uterus and detecting the expression of transient receptor potential cation channel subfamily V member 1 (Trpv-1), phospho (p)-p38 mitogen activated protein kinase p-extracellular signal-regulated kinase (p-ERK) in DRG neurons via immunohistochemistry.	Quercetin	58-67	mitogen-activated protein kinase 14	Mus musculus	400-403
28849202-6	2017	After 3 weeks of drug treatment, the potential ability of quercetin to improve the generalized hyperalgesia in mice with induced adenomyosis was evaluated by determining the body weight, pain modulation, examining the myometrial infiltration by histology examination of the uterus and detecting the expression of transient receptor potential cation channel subfamily V member 1 (Trpv-1), phospho (p)-p38 mitogen activated protein kinase p-extracellular signal-regulated kinase (p-ERK) in DRG neurons via immunohistochemistry.	Quercetin	58-67	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	437-476
28849202-6	2017	After 3 weeks of drug treatment, the potential ability of quercetin to improve the generalized hyperalgesia in mice with induced adenomyosis was evaluated by determining the body weight, pain modulation, examining the myometrial infiltration by histology examination of the uterus and detecting the expression of transient receptor potential cation channel subfamily V member 1 (Trpv-1), phospho (p)-p38 mitogen activated protein kinase p-extracellular signal-regulated kinase (p-ERK) in DRG neurons via immunohistochemistry.	Quercetin	58-67	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	478-483
28849202-7	2017	The results demonstrated that treatment with quercetin improved the generalized hyperalgesia by extending the hotplate response latency, reduced myometrial infiltration and decreased the expression levels Trpv-1, p-p38 and p-ERK in dorsal root ganglion neurons.	Quercetin	45-54	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	205-211
28849202-7	2017	The results demonstrated that treatment with quercetin improved the generalized hyperalgesia by extending the hotplate response latency, reduced myometrial infiltration and decreased the expression levels Trpv-1, p-p38 and p-ERK in dorsal root ganglion neurons.	Quercetin	45-54	mitogen-activated protein kinase 14	Mus musculus	215-218
28849202-7	2017	The results demonstrated that treatment with quercetin improved the generalized hyperalgesia by extending the hotplate response latency, reduced myometrial infiltration and decreased the expression levels Trpv-1, p-p38 and p-ERK in dorsal root ganglion neurons.	Quercetin	45-54	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	223-228
28668616-7	2017	Low levels of quercetin, myricetin and pentaacetylquercetin (10muM) stimulated cAMP-dependent Star, Cyp11a1 and Fdx1 promoters" activations and may increase steroidogenesis within Leydig cells.	Quercetin	14-23	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	100-107
28668616-7	2017	Low levels of quercetin, myricetin and pentaacetylquercetin (10muM) stimulated cAMP-dependent Star, Cyp11a1 and Fdx1 promoters" activations and may increase steroidogenesis within Leydig cells.	Quercetin	14-23	ferredoxin 1	Mus musculus	112-116
28902204-0	2017	Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL.	Quercetin	63-72	BCL2 like 1	Homo sapiens	129-135
28902204-4	2017	Herein, Induced Fit Docking (IFD) and Molecular Dynamics (MD) simulations were performed to rationally design quercetin analogues that bind in the BH3 site of the Bcl-xL protein.	Quercetin	110-119	BCL2 like 1	Homo sapiens	163-169
28902204-6	2017	The quercetin analogues were synthesized and their binding to Bcl-xL was verified with fluorescence spectroscopy.	Quercetin	4-13	BCL2 like 1	Homo sapiens	62-68
28902204-8	2017	2D 1H-15N HSQC NMR chemical shift perturbation mapping was used to chart the binding site of the quercetin analogues in the Bcl-xL that overlapped with the predicted poses generated by both IFD and MD calculations.	Quercetin	97-106	BCL2 like 1	Homo sapiens	124-130
28757412-0	2017	Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in mice.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	50-54
28757412-6	2017	Quercetin also prevented changes in the neuronal cell morphology and apoptosis in the hippocampus as well as increased the expression of Nrf2, HO-1 and SOD in d-galactose-treated mice.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
28757412-6	2017	Quercetin also prevented changes in the neuronal cell morphology and apoptosis in the hippocampus as well as increased the expression of Nrf2, HO-1 and SOD in d-galactose-treated mice.	Quercetin	0-9	heme oxygenase 1	Mus musculus	143-155
28757412-7	2017	Treatment with the Nrf2 inhibitor Brusatol reversed the effects of quercetin on HO-1 and SOD expression as well as neuronal cell protection.	Quercetin	67-76	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
28757412-7	2017	Treatment with the Nrf2 inhibitor Brusatol reversed the effects of quercetin on HO-1 and SOD expression as well as neuronal cell protection.	Quercetin	67-76	heme oxygenase 1	Mus musculus	80-92
29026320-0	2017	Quercetin inhibits epithelial-mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial-mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells.	Quercetin	0-9	interleukin 6	Homo sapiens	106-110
29026320-0	2017	Quercetin inhibits epithelial-mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial-mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	186-191
28757412-8	2017	In conclusion, quercetin protected mice from d-galactose-induced cognitive functional impairment and neuronal cell apoptosis via activation of the Nrf2-ARE signaling pathway.	Quercetin	15-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	147-151
29026320-5	2017	Meanwhile, we determined the activity of STAT3 after quercetin treatment.	Quercetin	53-62	signal transducer and activator of transcription 3	Homo sapiens	41-46
28842631-2	2017	In this study, we have evaluated different natural dietary polyphenolics including rutin, quercetin, ferulic acid, hesperidin, gallic acid and vanillin as MARK4 inhibitors.	Quercetin	90-99	microtubule affinity regulating kinase 4	Homo sapiens	155-160
29026320-6	2017	STAT3 phosphorylation decreased following treatment with quercetin.	Quercetin	57-66	signal transducer and activator of transcription 3	Homo sapiens	0-5
29026320-8	2017	As expected, the EMT and MMP secretion increased with activation of the STAT3 signaling pathway, and quercetin reversed IL-6-induced EMT, invasion, and migration.	Quercetin	101-110	interleukin 6	Homo sapiens	120-124
29026320-9	2017	Therefore, our results demonstrate that quercetin triggers inhibition of EMT, invasion, and metastasis by blocking the STAT3 signaling pathway, and thus, quercetin merits further investigation.	Quercetin	40-49	signal transducer and activator of transcription 3	Homo sapiens	119-124
28914791-0	2017	Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-kappaB and HO-1/Nrf2 Pathways.	Quercetin	0-9	nitric oxide synthase 2	Rattus norvegicus	122-126
28914791-0	2017	Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-kappaB and HO-1/Nrf2 Pathways.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	141-145
28914791-0	2017	Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-kappaB and HO-1/Nrf2 Pathways.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	146-150
28501572-0	2017	Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-beta2/phosphoinositide 3-kinase/Akt pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	186-189
28501572-9	2017	Treatment of the lens with quercetin ameliorated the oxidative stress, inhibited aldose reductase (AR) activation, reduced advanced glycation end product (AGE) production, and finally suppressed EMT in the early stages.	Quercetin	27-36	aldo-keto reductase family 1 member B	Homo sapiens	81-97
28501572-9	2017	Treatment of the lens with quercetin ameliorated the oxidative stress, inhibited aldose reductase (AR) activation, reduced advanced glycation end product (AGE) production, and finally suppressed EMT in the early stages.	Quercetin	27-36	aldo-keto reductase family 1 member B	Homo sapiens	99-101
28861887-0	2017	Combination of quercetin, cinnamaldehyde and hirudin protects rat dorsal root ganglion neurons against high glucose-induced injury through Nrf-2/HO-1 activation and NF-kappaB inhibition.	Quercetin	15-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	139-144
28552400-6	2017	In human liver cytosol, the combined effect of celecoxib and known SULT1A1 and 1E1 inhibitors, quercetin and triclosan, resulted in inhibition of 17beta-E2-3-sulfonation such that the 17-sulfate became the major metabolite: this is of interest because the 17-sulfate is not readily hydrolyzed by steroid sulfatase to 17beta-E2.	Quercetin	95-104	sulfotransferase family 1A member 1	Homo sapiens	67-82
28374530-0	2017	Binding of fluphenazine with human serum albumin in the presence of rutin and quercetin: An evaluation of food-drug interaction by spectroscopic techniques.	Quercetin	78-87	albumin	Homo sapiens	35-48
28713895-11	2017	In the quercetin group, the expression levels of Nrf2 and phase II enzymes (NQO1 and HO-1) were increased, whereas the levels of ER stress markers (binding of immunoglobulin protein, CCAAT/enhancer-binding protein homologous protein and phosphorylated eukaryotic translation initiation factor 2alpha) were reduced.	Quercetin	7-16	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
28713895-11	2017	In the quercetin group, the expression levels of Nrf2 and phase II enzymes (NQO1 and HO-1) were increased, whereas the levels of ER stress markers (binding of immunoglobulin protein, CCAAT/enhancer-binding protein homologous protein and phosphorylated eukaryotic translation initiation factor 2alpha) were reduced.	Quercetin	7-16	NAD(P)H quinone dehydrogenase 1	Homo sapiens	76-80
28713895-11	2017	In the quercetin group, the expression levels of Nrf2 and phase II enzymes (NQO1 and HO-1) were increased, whereas the levels of ER stress markers (binding of immunoglobulin protein, CCAAT/enhancer-binding protein homologous protein and phosphorylated eukaryotic translation initiation factor 2alpha) were reduced.	Quercetin	7-16	eukaryotic translation initiation factor 2A	Homo sapiens	252-299
28713895-13	2017	In conclusion, quercetin protected ARPE-19 cells from H2O2-induced cytotoxicity by activating the Nrf2 pathway, inhibiting ER stress and targeting anti-apoptotic proteins.	Quercetin	15-24	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
28589248-4	2017	Quercetin, a plant pigment (flavonoid), is an antioxidant and HO-1 inducer.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	62-66
28589248-12	2017	These findings suggest that quercetin has a hepatoprotective effect against I/R injury via HO-1 induction and unexpectedly, SnPP showed the similar effect.	Quercetin	28-37	heme oxygenase 1	Rattus norvegicus	91-95
28589248-13	2017	Quercetin has more prominent protective effect than SnPP because of its superior ability to induce HO-1.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	99-103
28639379-9	2017	Finally, molecular docking studies of the constituent quercetin were undertaken in silico and several sites of binding to human estrogen receptor (ER) protein, linked with alkaline phosphatase, identified.	Quercetin	54-63	estrogen receptor 1	Homo sapiens	128-145
28639379-9	2017	Finally, molecular docking studies of the constituent quercetin were undertaken in silico and several sites of binding to human estrogen receptor (ER) protein, linked with alkaline phosphatase, identified.	Quercetin	54-63	estrogen receptor 1	Homo sapiens	147-149
28839277-0	2017	Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-beta1/Smads and PI3K/Akt pathways.	Quercetin	0-9	transforming growth factor, beta 1	Mus musculus	114-123
28839277-0	2017	Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-beta1/Smads and PI3K/Akt pathways.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	139-142
28839277-5	2017	The results of our experiments showed that quercetin reduced BDL or CCl4 liver fibrosis, inhibited extracellular matrix formation, and regulated matrix metallopeptidase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1.	Quercetin	43-52	chemokine (C-C motif) ligand 4	Mus musculus	68-72
28839277-5	2017	The results of our experiments showed that quercetin reduced BDL or CCl4 liver fibrosis, inhibited extracellular matrix formation, and regulated matrix metallopeptidase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1.	Quercetin	43-52	matrix metallopeptidase 9	Mus musculus	145-176
28894166-4	2017	We have analyzed the effect of the flavonoid quercetin on the conformation, stability and function of the G protein-coupled receptor rhodopsin, and the G90V mutant associated with the retinal degenerative disease retinitis pigmentosa.	Quercetin	45-54	rhodopsin	Homo sapiens	133-142
28501572-12	2017	Quercetin was potent enough to effectively ameliorate the high glucose (HG)-induced EMT of SRA01/04 cells by inhibiting the activation of TGF-beta2/PI3K/Akt, enhancing the antioxidant capacity, inhibiting AR activity, and reducing AGE production.	Quercetin	0-9	transforming growth factor beta 2	Homo sapiens	138-147
28501572-12	2017	Quercetin was potent enough to effectively ameliorate the high glucose (HG)-induced EMT of SRA01/04 cells by inhibiting the activation of TGF-beta2/PI3K/Akt, enhancing the antioxidant capacity, inhibiting AR activity, and reducing AGE production.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	153-156
28501572-12	2017	Quercetin was potent enough to effectively ameliorate the high glucose (HG)-induced EMT of SRA01/04 cells by inhibiting the activation of TGF-beta2/PI3K/Akt, enhancing the antioxidant capacity, inhibiting AR activity, and reducing AGE production.	Quercetin	0-9	aldo-keto reductase family 1 member B	Homo sapiens	205-207
28513167-0	2017	Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6.	Quercetin	0-9	solute carrier family 16 member 5	Homo sapiens	78-107
28513167-4	2017	The uptake of bumetanide in human MCT6 gene-transfected Xenopus laevis oocytes was significantly decreased in the presence of a variety of flavonoids (e.g., quercetin, luteolin, phloretin, and morin), but was not significantly affected by flavonoid glycosides (e.g., naringin, rutin, phlorizin).	Quercetin	157-166	solute carrier family 16 member 5	Homo sapiens	34-38
28805023-15	2017	These results suggest OPE, which is rich in the potent Hv1 channel activator quercetin, as a possible new candidate treatment for human infertility.	Quercetin	77-86	hydrogen voltage gated channel 1	Homo sapiens	55-58
28537580-0	2017	Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials.	Quercetin	32-41	C-reactive protein	Homo sapiens	52-70
28537580-2	2017	However, the results of current clinical trials on quercetin"s effects on the C-reactive protein (CRP), a sensitive inflammatory biomarker, are ambiguous.	Quercetin	51-60	C-reactive protein	Homo sapiens	78-96
28537580-2	2017	However, the results of current clinical trials on quercetin"s effects on the C-reactive protein (CRP), a sensitive inflammatory biomarker, are ambiguous.	Quercetin	51-60	C-reactive protein	Homo sapiens	98-101
28537580-3	2017	We conducted a meta-analysis of available randomized controlled trials (RCTs) to resolve this inconsistency and quantify the net effect of quercetin on circulating CRP concentrations.	Quercetin	139-148	C-reactive protein	Homo sapiens	164-167
28537580-7	2017	The meta-analysis of seven RCTs (10 treatment arms) showed a significant reduction of circulating CRP levels (WMD: -0.33 mg/l; 95% CI: -0.50 to -0.15; P&lt;0.001) following quercetin supplementation.	Quercetin	173-182	C-reactive protein	Homo sapiens	98-101
28537580-10	2017	Our findings showed a significant effect of quercetin supplementation on the C-reactive protein-especially at doses above 500 mg/day and in patients with CRP &lt;3 mg/l.	Quercetin	44-53	C-reactive protein	Homo sapiens	77-95
28537580-10	2017	Our findings showed a significant effect of quercetin supplementation on the C-reactive protein-especially at doses above 500 mg/day and in patients with CRP &lt;3 mg/l.	Quercetin	44-53	C-reactive protein	Homo sapiens	154-157
28457022-3	2017	METHODS AND RESULTS: Quercetin consumption inhibited DC activation, inflammatory response and suppressed the progression of atherosclerosis in ApoE-/- mice.	Quercetin	21-30	apolipoprotein E	Mus musculus	143-147
28457022-4	2017	Subsequently, quercetin treatment inhibited the phenotypic and functional maturation of DCs, as evidenced not only by downregulation of CD80, CD86, MHC-II, IL-6 and IL-12 but also by a reduction in the ability to stimulate T cell allogeneic proliferation.	Quercetin	14-23	CD80 antigen	Mus musculus	136-140
28457022-4	2017	Subsequently, quercetin treatment inhibited the phenotypic and functional maturation of DCs, as evidenced not only by downregulation of CD80, CD86, MHC-II, IL-6 and IL-12 but also by a reduction in the ability to stimulate T cell allogeneic proliferation.	Quercetin	14-23	CD86 antigen	Mus musculus	142-146
28457022-4	2017	Subsequently, quercetin treatment inhibited the phenotypic and functional maturation of DCs, as evidenced not only by downregulation of CD80, CD86, MHC-II, IL-6 and IL-12 but also by a reduction in the ability to stimulate T cell allogeneic proliferation.	Quercetin	14-23	histocompatibility-2, MHC	Mus musculus	148-154
28457022-4	2017	Subsequently, quercetin treatment inhibited the phenotypic and functional maturation of DCs, as evidenced not only by downregulation of CD80, CD86, MHC-II, IL-6 and IL-12 but also by a reduction in the ability to stimulate T cell allogeneic proliferation.	Quercetin	14-23	interleukin 6	Mus musculus	156-160
28457022-6	2017	CONCLUSIONS: Our data indicate that quercetin attenuates atherosclerosis progression by regulating DC activation via Dab2 protein expression.	Quercetin	36-45	disabled 2, mitogen-responsive phosphoprotein	Mus musculus	117-121
28927086-0	2017	Quercetin inhibits angiogenesis-mediated human retinoblastoma growth by targeting vascular endothelial growth factor receptor.	Quercetin	0-9	kinase insert domain receptor	Homo sapiens	82-125
28855811-9	2017	Our results indicate that quercetin treatment to diabetic rats caused a significant increase in the level of neurotrophic factors and inhibited the level of cytochrome c and caspase-3 activity in the diabetic retina.	Quercetin	26-35	caspase 3	Rattus norvegicus	174-183
28855811-10	2017	Furthermore, the level of an anti-apoptotic protein Bcl-2 was augmented in quercetin treated diabetic retina.	Quercetin	75-84	BCL2, apoptosis regulator	Rattus norvegicus	52-57
28839277-5	2017	The results of our experiments showed that quercetin reduced BDL or CCl4 liver fibrosis, inhibited extracellular matrix formation, and regulated matrix metallopeptidase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1.	Quercetin	43-52	tissue inhibitor of metalloproteinase 1	Mus musculus	181-227
28839277-6	2017	Quercetin attenuated liver damage by suppressing the TGF-beta1/Smads signaling pathway and activating the PI3K/Akt signaling pathway to inhibit autophagy in BDL- or CCl4- induced liver fibrosis.	Quercetin	0-9	transforming growth factor, beta 1	Mus musculus	53-62
28839277-6	2017	Quercetin attenuated liver damage by suppressing the TGF-beta1/Smads signaling pathway and activating the PI3K/Akt signaling pathway to inhibit autophagy in BDL- or CCl4- induced liver fibrosis.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	111-114
28839277-6	2017	Quercetin attenuated liver damage by suppressing the TGF-beta1/Smads signaling pathway and activating the PI3K/Akt signaling pathway to inhibit autophagy in BDL- or CCl4- induced liver fibrosis.	Quercetin	0-9	chemokine (C-C motif) ligand 4	Mus musculus	165-169
28839277-7	2017	Quercetin prevented hepatic fibrosis by attenuating hepatic stellate cell activation and reducing autophagy through regulating crosstalk between the TGF-beta1/Smads and PI3K/Akt pathways.	Quercetin	0-9	transforming growth factor, beta 1	Mus musculus	149-158
28839277-7	2017	Quercetin prevented hepatic fibrosis by attenuating hepatic stellate cell activation and reducing autophagy through regulating crosstalk between the TGF-beta1/Smads and PI3K/Akt pathways.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	174-177
28860810-6	2017	The inhibitory effect of quercetin on migration and angiogenesis is possibly mediated through the downregulation of protein levels of VEGFA, MMP9, and MMP2 as detected by Western blot.	Quercetin	25-34	vascular endothelial growth factor A	Homo sapiens	134-139
28745879-5	2017	The quercetin treated with the plasma for 20 min showed rapidly increased alpha-glucosidase inhibitory and radical scavenging activities compared to those of parent quercetin.	Quercetin	4-13	sucrase-isomaltase	Homo sapiens	74-91
28860810-6	2017	The inhibitory effect of quercetin on migration and angiogenesis is possibly mediated through the downregulation of protein levels of VEGFA, MMP9, and MMP2 as detected by Western blot.	Quercetin	25-34	matrix metallopeptidase 9	Homo sapiens	141-145
28860810-6	2017	The inhibitory effect of quercetin on migration and angiogenesis is possibly mediated through the downregulation of protein levels of VEGFA, MMP9, and MMP2 as detected by Western blot.	Quercetin	25-34	matrix metallopeptidase 2	Homo sapiens	151-155
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
28577496-7	2017	The oral pretreatment with encapsulated quercetin (0.18mg/kg b.w., 7days) significantly diminished the increased levels of serum transaminases ALT and AST, attenuated the lipid peroxidation and restored the levels of gluthation (a marker of cell antioxidant defence system).	Quercetin	40-49	solute carrier family 17 member 5	Homo sapiens	151-154
28462502-2	2017	Quercetin is a plant-based flavonoid with inhibitory effects on P-glycoprotein (P-gp) and CYP3A4 and also antioxidant properties.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	64-78
28462502-2	2017	Quercetin is a plant-based flavonoid with inhibitory effects on P-glycoprotein (P-gp) and CYP3A4 and also antioxidant properties.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	80-84
28462502-2	2017	Quercetin is a plant-based flavonoid with inhibitory effects on P-glycoprotein (P-gp) and CYP3A4 and also antioxidant properties.	Quercetin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-96
28479391-0	2017	Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression.	Quercetin	35-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
28479391-3	2017	IC50 of Quercetin for HT29 and HCT15 cells were 42.5 muM and 77.4 muM, respectively.	Quercetin	8-17	latexin	Homo sapiens	53-56
28528183-4	2017	Quercetin treatment also induced apoptosis via deregulating the expression of apoptotic genes, including Bax and Bcl-2, and arrested cell cycle at G2/M phases.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	105-108
28528183-4	2017	Quercetin treatment also induced apoptosis via deregulating the expression of apoptotic genes, including Bax and Bcl-2, and arrested cell cycle at G2/M phases.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	113-118
28528183-5	2017	We further found that quercetin impaired cell migration and invasion via downregulating the expression of matrix metallopeptidases MMP9 and MMP2.	Quercetin	22-31	matrix metallopeptidase 9	Homo sapiens	131-135
28528183-5	2017	We further found that quercetin impaired cell migration and invasion via downregulating the expression of matrix metallopeptidases MMP9 and MMP2.	Quercetin	22-31	matrix metallopeptidase 2	Homo sapiens	140-144
27896629-7	2017	Furthermore, the administration of YC-1 (HIF-1 inhibitor), 8-bAMP (AMPK inhibitor), and Quercetin (HSP70 inhibitor) to MCAO+RIPC rats demonstrated that HIF-1alpha/AMPK/HSP70 was involved in RIPC-mediated protection against cerebral ischemia.	Quercetin	88-97	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	99-104
27896629-7	2017	Furthermore, the administration of YC-1 (HIF-1 inhibitor), 8-bAMP (AMPK inhibitor), and Quercetin (HSP70 inhibitor) to MCAO+RIPC rats demonstrated that HIF-1alpha/AMPK/HSP70 was involved in RIPC-mediated protection against cerebral ischemia.	Quercetin	88-97	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	152-162
27896629-7	2017	Furthermore, the administration of YC-1 (HIF-1 inhibitor), 8-bAMP (AMPK inhibitor), and Quercetin (HSP70 inhibitor) to MCAO+RIPC rats demonstrated that HIF-1alpha/AMPK/HSP70 was involved in RIPC-mediated protection against cerebral ischemia.	Quercetin	88-97	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	163-167
28493194-9	2017	In immunohistochemical evaluation, it was detected that COX-2 and VIP expressions were weaker in the quercetin group compared to the control group.	Quercetin	101-110	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	56-61
28493194-9	2017	In immunohistochemical evaluation, it was detected that COX-2 and VIP expressions were weaker in the quercetin group compared to the control group.	Quercetin	101-110	vasoactive intestinal peptide	Rattus norvegicus	66-69
28549404-0	2017	The impact of quercetin on wound healing relates to changes in alphaV and beta1 integrin expression.	Quercetin	14-23	hemoglobin, beta adult major chain	Mus musculus	74-79
28549404-5	2017	While cultured fibroblasts demonstrated normal growth in response to quercetin, quercetin increased surface alphaV integrin and decreased beta1 integrin.	Quercetin	80-89	integrin alpha V	Mus musculus	108-123
28549404-5	2017	While cultured fibroblasts demonstrated normal growth in response to quercetin, quercetin increased surface alphaV integrin and decreased beta1 integrin.	Quercetin	80-89	hemoglobin, beta adult major chain	Mus musculus	138-143
28549404-10	2017	The extracellular matrix also ameliorated quercetin"s effect on alphaV integrin.	Quercetin	42-51	integrin alpha V	Mus musculus	64-79
28549404-11	2017	Thus, alphaV integrin recruitment in response to quercetin treatment may promote the quercetin-mediated decrease extracellular matrix because cells require less extracellular matrix to migrate into a wound.	Quercetin	49-58	integrin alpha V	Mus musculus	6-21
28549404-11	2017	Thus, alphaV integrin recruitment in response to quercetin treatment may promote the quercetin-mediated decrease extracellular matrix because cells require less extracellular matrix to migrate into a wound.	Quercetin	85-94	integrin alpha V	Mus musculus	6-21
28549404-12	2017	With added extracellular matrix, beta1 integrin remained diminished in response to quercetin, indicating that quercetin"s effect on beta1 integrin expression is independent of extracellular matrix -mediated signaling and is likely driven by inhibition of the intracellular mechanisms driving beta1 expression.	Quercetin	83-92	hemoglobin, beta adult major chain	Mus musculus	33-38
28549404-12	2017	With added extracellular matrix, beta1 integrin remained diminished in response to quercetin, indicating that quercetin"s effect on beta1 integrin expression is independent of extracellular matrix -mediated signaling and is likely driven by inhibition of the intracellular mechanisms driving beta1 expression.	Quercetin	110-119	hemoglobin, beta adult major chain	Mus musculus	33-38
28549404-12	2017	With added extracellular matrix, beta1 integrin remained diminished in response to quercetin, indicating that quercetin"s effect on beta1 integrin expression is independent of extracellular matrix -mediated signaling and is likely driven by inhibition of the intracellular mechanisms driving beta1 expression.	Quercetin	110-119	hemoglobin, beta adult major chain	Mus musculus	132-137
28549404-12	2017	With added extracellular matrix, beta1 integrin remained diminished in response to quercetin, indicating that quercetin"s effect on beta1 integrin expression is independent of extracellular matrix -mediated signaling and is likely driven by inhibition of the intracellular mechanisms driving beta1 expression.	Quercetin	110-119	hemoglobin, beta adult major chain	Mus musculus	132-137
28479391-3	2017	IC50 of Quercetin for HT29 and HCT15 cells were 42.5 muM and 77.4 muM, respectively.	Quercetin	8-17	latexin	Homo sapiens	66-69
28479391-4	2017	Activation of caspase-3, increased level of cytosolic cytochrome c, decreased levels of pAkt, pGSK-3beta and cyclin D1 in 40 muM Quercetin treated HT29 cells alone.	Quercetin	129-138	caspase 3	Homo sapiens	14-23
28479391-4	2017	Activation of caspase-3, increased level of cytosolic cytochrome c, decreased levels of pAkt, pGSK-3beta and cyclin D1 in 40 muM Quercetin treated HT29 cells alone.	Quercetin	129-138	cytochrome c, somatic	Homo sapiens	54-66
28479391-4	2017	Activation of caspase-3, increased level of cytosolic cytochrome c, decreased levels of pAkt, pGSK-3beta and cyclin D1 in 40 muM Quercetin treated HT29 cells alone.	Quercetin	129-138	cyclin D1	Homo sapiens	109-118
28479391-4	2017	Activation of caspase-3, increased level of cytosolic cytochrome c, decreased levels of pAkt, pGSK-3beta and cyclin D1 in 40 muM Quercetin treated HT29 cells alone.	Quercetin	129-138	latexin	Homo sapiens	125-128
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	62-71	latexin	Homo sapiens	58-61
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	62-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	latexin	Homo sapiens	58-61
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	latexin	Homo sapiens	146-149
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	latexin	Homo sapiens	58-61
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	latexin	Homo sapiens	146-149
28479391-5	2017	Though, nuclear translocation of NFkB was increased in 40 muM Quercetin treated HT29 and HCT15 cells, over expression of COX-2 was observed in 40 muM Quercetin treated HT29 cells, whereas, Quercetin treated HCT15 cells did not expressed COX-2.	Quercetin	150-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Quercetin	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Quercetin	75-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Quercetin	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
28479391-6	2017	Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation.	Quercetin	176-185	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	150-155
28479391-7	2017	Insilico analysis provided evidence that Quercetin could partially inhibit COX-2 enzyme by binding to subunit A which has peroxidase activity and serves as source of ROS.	Quercetin	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
28479391-9	2017	To conclude, differential sensitivity of two cancer cells, HT29 and HCT15, to Quercetin depends on COX-2 dependent ROS generation that induces apoptosis and inhibits cell survival.	Quercetin	78-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
28350760-10	2017	Pretreatment with quercetin, an inhibitor of HSP70, or SnPP, an inhibitor of HO-1, reversed the protective effects of raloxifene in septic OVX rats and LPS-activated macrophages.	Quercetin	18-27	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	45-50
28431985-5	2017	RESULTS: Administration of 50mg/kg/day quercetin causes increased in uterine fluid volume and CFTR expression but decreased in gamma-ENaC, AQP-5, AQP-9 claudin-4, occludin, E-cadherin, integrin alphanbetaZ, FGF, Ihh and Msx-1expression in the uterus.	Quercetin	39-48	CF transmembrane conductance regulator	Rattus norvegicus	94-98
28586024-1	2017	The present study aimed to investigate the effect of quercetin on cytotoxicity and cognitive degradation induced by amyloid beta(Abeta)-peptide in mice.	Quercetin	53-62	histocompatibility 2, class II antigen A, beta 1	Mus musculus	129-134
28586024-4	2017	For determination of the effect of quercetin on degradation of learning and memory loss induced by Abeta, a passive avoidance test was used.	Quercetin	35-44	histocompatibility 2, class II antigen A, beta 1	Mus musculus	99-104
28586024-6	2017	Quercetin significantly protected PC12 neuronal cells from death induced by Abeta treatment.	Quercetin	0-9	amyloid beta precursor protein	Rattus norvegicus	76-81
28586024-7	2017	Treatment of mice with daily doses of 100 mg/kg body weight quercetin for 30 days significantly improved the degradation of learning and memory loss induced by Abeta.	Quercetin	60-69	histocompatibility 2, class II antigen A, beta 1	Mus musculus	160-165
28677813-4	2017	Moreover, quercetin significantly induced the apoptosis of the CT-26, LNCaP, MOLT-4 and Raji cell lines, as compared to control group (P&lt;0.001), as demonstrated by Annexin V/PI staining.	Quercetin	10-19	annexin A5	Homo sapiens	167-176
28431985-5	2017	RESULTS: Administration of 50mg/kg/day quercetin causes increased in uterine fluid volume and CFTR expression but decreased in gamma-ENaC, AQP-5, AQP-9 claudin-4, occludin, E-cadherin, integrin alphanbetaZ, FGF, Ihh and Msx-1expression in the uterus.	Quercetin	39-48	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	127-137
28431985-5	2017	RESULTS: Administration of 50mg/kg/day quercetin causes increased in uterine fluid volume and CFTR expression but decreased in gamma-ENaC, AQP-5, AQP-9 claudin-4, occludin, E-cadherin, integrin alphanbetaZ, FGF, Ihh and Msx-1expression in the uterus.	Quercetin	39-48	aquaporin 5	Rattus norvegicus	139-144
28431985-5	2017	RESULTS: Administration of 50mg/kg/day quercetin causes increased in uterine fluid volume and CFTR expression but decreased in gamma-ENaC, AQP-5, AQP-9 claudin-4, occludin, E-cadherin, integrin alphanbetaZ, FGF, Ihh and Msx-1expression in the uterus.	Quercetin	39-48	aquaporin 9	Rattus norvegicus	146-151
28431985-5	2017	RESULTS: Administration of 50mg/kg/day quercetin causes increased in uterine fluid volume and CFTR expression but decreased in gamma-ENaC, AQP-5, AQP-9 claudin-4, occludin, E-cadherin, integrin alphanbetaZ, FGF, Ihh and Msx-1expression in the uterus.	Quercetin	39-48	claudin 4	Rattus norvegicus	152-161
28431985-5	2017	RESULTS: Administration of 50mg/kg/day quercetin causes increased in uterine fluid volume and CFTR expression but decreased in gamma-ENaC, AQP-5, AQP-9 claudin-4, occludin, E-cadherin, integrin alphanbetaZ, FGF, Ihh and Msx-1expression in the uterus.	Quercetin	39-48	occludin	Rattus norvegicus	163-171
28431985-5	2017	RESULTS: Administration of 50mg/kg/day quercetin causes increased in uterine fluid volume and CFTR expression but decreased in gamma-ENaC, AQP-5, AQP-9 claudin-4, occludin, E-cadherin, integrin alphanbetaZ, FGF, Ihh and Msx-1expression in the uterus.	Quercetin	39-48	cadherin 1	Rattus norvegicus	173-183
28431985-5	2017	RESULTS: Administration of 50mg/kg/day quercetin causes increased in uterine fluid volume and CFTR expression but decreased in gamma-ENaC, AQP-5, AQP-9 claudin-4, occludin, E-cadherin, integrin alphanbetaZ, FGF, Ihh and Msx-1expression in the uterus.	Quercetin	39-48	Indian hedgehog signaling molecule	Rattus norvegicus	212-215
28431985-5	2017	RESULTS: Administration of 50mg/kg/day quercetin causes increased in uterine fluid volume and CFTR expression but decreased in gamma-ENaC, AQP-5, AQP-9 claudin-4, occludin, E-cadherin, integrin alphanbetaZ, FGF, Ihh and Msx-1expression in the uterus.	Quercetin	39-48	msh homeobox 1	Rattus norvegicus	220-225
28930270-8	2017	Increase in ERK1/2 phosphorylation in response to leptin was reduced by the addition of quercetin, curcumin and EGCG.	Quercetin	88-97	mitogen-activated protein kinase 3	Homo sapiens	12-18
28248534-9	2017	Pretreatment of D-GalN/LPS rats with either quercetin or SRT1720 returned SIRT1 expression, HO-1 expression and all the aforementioned markers towards normal.	Quercetin	44-53	galanin and GMAP prepropeptide	Rattus norvegicus	18-22
28661143-7	2017	IFPTarget prediction led to the identification of the metallo-beta-lactamase VIM-2 as a target for quercetin as validated by enzymatic inhibition assays.	Quercetin	99-108	vimentin 2, pseudogene	Homo sapiens	77-82
28644504-4	2017	Here, we report the X-ray crystal structure of quercetin in a complex with the urokinase-type plasminogen activator (uPA), an archetypical serine protease.	Quercetin	47-56	plasminogen activator, urokinase	Homo sapiens	79-115
28644504-4	2017	Here, we report the X-ray crystal structure of quercetin in a complex with the urokinase-type plasminogen activator (uPA), an archetypical serine protease.	Quercetin	47-56	plasminogen activator, urokinase	Homo sapiens	117-120
28644504-4	2017	Here, we report the X-ray crystal structure of quercetin in a complex with the urokinase-type plasminogen activator (uPA), an archetypical serine protease.	Quercetin	47-56	coagulation factor II, thrombin	Homo sapiens	139-154
28644504-5	2017	The structure showed that quercetin binds to the specific substrate binding pocket (S1 pocket) of uPA mainly through its two neighboring phenolic hydroxyl groups.	Quercetin	26-35	plasminogen activator, urokinase	Homo sapiens	98-101
28248534-9	2017	Pretreatment of D-GalN/LPS rats with either quercetin or SRT1720 returned SIRT1 expression, HO-1 expression and all the aforementioned markers towards normal.	Quercetin	44-53	sirtuin 1	Rattus norvegicus	74-79
28248534-9	2017	Pretreatment of D-GalN/LPS rats with either quercetin or SRT1720 returned SIRT1 expression, HO-1 expression and all the aforementioned markers towards normal.	Quercetin	44-53	heme oxygenase 1	Rattus norvegicus	92-96
28450151-10	2017	The expression levels of both myostatin A (mstna) and myogenic differentiation (myoD) were also altered by quercetin.	Quercetin	107-116	myostatin a	Danio rerio	30-41
28450151-10	2017	The expression levels of both myostatin A (mstna) and myogenic differentiation (myoD) were also altered by quercetin.	Quercetin	107-116	myostatin a	Danio rerio	43-48
28450151-10	2017	The expression levels of both myostatin A (mstna) and myogenic differentiation (myoD) were also altered by quercetin.	Quercetin	107-116	myogenic differentiation 1	Danio rerio	80-84
28450151-11	2017	Mstna, an inhibitory factor for myogenesis, was significantly increased at 1mug/L quercetin exposure, while myoD, a stimulatory factor for myogenesis, was significantly increased at 10mug/L quercetin exposure.	Quercetin	82-91	myostatin a	Danio rerio	0-5
28450151-11	2017	Mstna, an inhibitory factor for myogenesis, was significantly increased at 1mug/L quercetin exposure, while myoD, a stimulatory factor for myogenesis, was significantly increased at 10mug/L quercetin exposure.	Quercetin	190-199	myogenic differentiation 1	Danio rerio	108-112
28684695-0	2017	Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure.	Quercetin	133-142	secretory leukocyte peptidase inhibitor	Mus musculus	0-33
28684704-9	2017	In addition, quercetin pretreatment significantly increased Bcl-2 expression, and reduced Bax, cleaved caspase-3 and p53 expressions.	Quercetin	13-22	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	117-120
28684695-0	2017	Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure.	Quercetin	133-142	secretory leukocyte peptidase inhibitor	Mus musculus	35-39
28684695-4	2017	We recently identified the Slpi expression as a crucial checkpoint required for the quercetin-induced inflammatory suppression.	Quercetin	84-93	secretory leukocyte peptidase inhibitor	Mus musculus	27-31
28684695-5	2017	Here we demonstrate that Slpi-KO DCs secrete a unique panel of cytokines and chemokines following quercetin exposure.	Quercetin	98-107	secretory leukocyte peptidase inhibitor	Mus musculus	25-29
28684695-6	2017	In vivo, quercetin-enriched food is able to induce Slpi expression in the ileum, while little effects are detectable in the duodenum.	Quercetin	9-18	secretory leukocyte peptidase inhibitor	Mus musculus	51-55
28684695-7	2017	Furthermore, Slpi expressing cells are more frequent at the tip compared to the base of the intestinal villi, suggesting that quercetin exposure could be more efficient for DCs projecting periscopes in the intestinal lumen.	Quercetin	126-135	secretory leukocyte peptidase inhibitor	Mus musculus	13-17
28684704-9	2017	In addition, quercetin pretreatment significantly increased Bcl-2 expression, and reduced Bax, cleaved caspase-3 and p53 expressions.	Quercetin	13-22	BCL2, apoptosis regulator	Rattus norvegicus	60-65
28684704-9	2017	In addition, quercetin pretreatment significantly increased Bcl-2 expression, and reduced Bax, cleaved caspase-3 and p53 expressions.	Quercetin	13-22	BCL2 associated X, apoptosis regulator	Rattus norvegicus	90-93
28251795-4	2017	Quercetin-induced G0 /G1 -phase arrest occurred when expressions of cyclin-dependent kinase (CDK)2/4 were inhibited and the CDK inhibitors, p16 and p21, were induced.	Quercetin	0-9	cyclin dependent kinase 2	Homo sapiens	93-98
28251795-4	2017	Quercetin-induced G0 /G1 -phase arrest occurred when expressions of cyclin-dependent kinase (CDK)2/4 were inhibited and the CDK inhibitors, p16 and p21, were induced.	Quercetin	0-9	cyclin dependent kinase inhibitor 2A	Homo sapiens	140-143
28251795-4	2017	Quercetin-induced G0 /G1 -phase arrest occurred when expressions of cyclin-dependent kinase (CDK)2/4 were inhibited and the CDK inhibitors, p16 and p21, were induced.	Quercetin	0-9	H3 histone pseudogene 16	Homo sapiens	148-151
28251795-5	2017	Moreover, quercetin treatment not only activated proapoptotic signaling like poly (ADP ribose) polymerase (PARP)-1 cleavage and caspase activation but also triggered autophagy events as shown by the increased expression of light chain 3 (LC3)-II, decreased expression of p62, and formation of acidic vesicular organelles.	Quercetin	10-19	poly(ADP-ribose) polymerase 1	Homo sapiens	77-114
28251795-5	2017	Moreover, quercetin treatment not only activated proapoptotic signaling like poly (ADP ribose) polymerase (PARP)-1 cleavage and caspase activation but also triggered autophagy events as shown by the increased expression of light chain 3 (LC3)-II, decreased expression of p62, and formation of acidic vesicular organelles.	Quercetin	10-19	nucleoporin 62	Homo sapiens	271-274
28351769-0	2017	Quercetin attenuates high fat diet-induced atherosclerosis in apolipoprotein E knockout mice: A critical role of NADPH oxidase.	Quercetin	0-9	apolipoprotein E	Mus musculus	62-78
28351769-6	2017	Quercetin significantly reduced the atherosclerotic plaque area, alleviated the systemic oxidative stress, and suppressed aortic p47phox, p67phox expressions but partially reversed the NOX4 expression as compared to those in the HFD group.	Quercetin	0-9	neutrophil cytosolic factor 1	Mus musculus	129-136
28351769-6	2017	Quercetin significantly reduced the atherosclerotic plaque area, alleviated the systemic oxidative stress, and suppressed aortic p47phox, p67phox expressions but partially reversed the NOX4 expression as compared to those in the HFD group.	Quercetin	0-9	neutrophil cytosolic factor 2	Mus musculus	138-145
28351769-6	2017	Quercetin significantly reduced the atherosclerotic plaque area, alleviated the systemic oxidative stress, and suppressed aortic p47phox, p67phox expressions but partially reversed the NOX4 expression as compared to those in the HFD group.	Quercetin	0-9	NADPH oxidase 4	Mus musculus	185-189
28351769-7	2017	In vitro, quercetin effectively inhibited the ox-LDL induced ROS formation in MPMs, and blocked the vital step in activation of NADPH oxidase - membrane translocation of p47phox.	Quercetin	10-19	neutrophil cytosolic factor 1	Mus musculus	170-177
28545670-11	2017	The mRNA levels of IFN-alpha, IFN-lambda, TNF-alpha, Mx, and ZAP were upregulated in RAW 264.7 cells pre-treated with fisetin, quercetin, and daidzein, but not in those pre-treated with EGCG or ECG.	Quercetin	127-136	interferon alpha	Mus musculus	19-28
28499194-0	2017	Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-kappaB pathway.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-98
28545670-11	2017	The mRNA levels of IFN-alpha, IFN-lambda, TNF-alpha, Mx, and ZAP were upregulated in RAW 264.7 cells pre-treated with fisetin, quercetin, and daidzein, but not in those pre-treated with EGCG or ECG.	Quercetin	127-136	tumor necrosis factor	Mus musculus	42-51
28545670-11	2017	The mRNA levels of IFN-alpha, IFN-lambda, TNF-alpha, Mx, and ZAP were upregulated in RAW 264.7 cells pre-treated with fisetin, quercetin, and daidzein, but not in those pre-treated with EGCG or ECG.	Quercetin	127-136	zinc finger CCCH type, antiviral 1	Mus musculus	61-64
28545670-12	2017	Regarding protein levels, IFN-alpha was significantly induced in cells pre-treated with fisetin, quercetin, and daidzein, whereas TNF-alpha was significantly induced only in cells pre-treated with daidzein.	Quercetin	97-106	interferon alpha	Mus musculus	26-35
28395272-6	2017	Hesperidin and quercetin caused significant increase in the SIRT1, SOD and CAT activities of both DM+HP and DM+Q groups kidney tissues compared to DM group (p&lt;0.05).	Quercetin	15-24	sirtuin 1	Rattus norvegicus	60-65
28489572-6	2017	We confirmed that quercetin in association with ABT-737 synergistically enhances apoptosis in HG3 (combination index &lt; 1 for all fractions affected).	Quercetin	18-27	polycystin 1, transient receptor potential channel interacting pseudogene 3	Homo sapiens	94-97
28489572-8	2017	We demonstrated that the activity of protein kinase CK2, which positively triggers PI3K/Akt pathway by inactivating PTEN phosphatase, is inhibited by quercetin immediately after its addition to HG3 cells (0-2 min).	Quercetin	150-159	AKT serine/threonine kinase 1	Homo sapiens	88-91
28489572-8	2017	We demonstrated that the activity of protein kinase CK2, which positively triggers PI3K/Akt pathway by inactivating PTEN phosphatase, is inhibited by quercetin immediately after its addition to HG3 cells (0-2 min).	Quercetin	150-159	polycystin 1, transient receptor potential channel interacting pseudogene 3	Homo sapiens	194-197
28644409-0	2017	Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction.	Quercetin	0-9	heme oxygenase 1	Mus musculus	119-123
28644409-3	2017	Here, we demonstrate that quercetin reduces obesity-induced hypothalamic inflammation by inhibiting microglia-mediated inflammatory responses, and the beneficial action of quercetin is associated with heme oxygenase (HO-1) induction.	Quercetin	172-181	heme oxygenase 1	Mus musculus	217-221
28644409-4	2017	Quercetin markedly reduced the production of inflammatory mediators (monocyte chemoattractant protein (MCP)-1, interleukin (IL-6), IL-1beta, nitric oxide) by microglia stimulated with saturated fatty acid palmitate and/or lipid-laden microglia-conditioned medium.	Quercetin	0-9	chemokine (C-C motif) ligand 2	Mus musculus	69-109
28644409-4	2017	Quercetin markedly reduced the production of inflammatory mediators (monocyte chemoattractant protein (MCP)-1, interleukin (IL-6), IL-1beta, nitric oxide) by microglia stimulated with saturated fatty acid palmitate and/or lipid-laden microglia-conditioned medium.	Quercetin	0-9	interleukin 1 beta	Mus musculus	131-139
28644409-5	2017	Quercetin also upregulated the expression of HO-1 in palmitate-treated lipid-laden microglia, and the actions of quercetin against microglia activation accompanied by IkappaBalpha degradation were abolished by a HO-1 inhibitor.	Quercetin	0-9	heme oxygenase 1	Mus musculus	45-49
28644409-5	2017	Quercetin also upregulated the expression of HO-1 in palmitate-treated lipid-laden microglia, and the actions of quercetin against microglia activation accompanied by IkappaBalpha degradation were abolished by a HO-1 inhibitor.	Quercetin	0-9	heme oxygenase 1	Mus musculus	212-216
28644409-5	2017	Quercetin also upregulated the expression of HO-1 in palmitate-treated lipid-laden microglia, and the actions of quercetin against microglia activation accompanied by IkappaBalpha degradation were abolished by a HO-1 inhibitor.	Quercetin	113-122	heme oxygenase 1	Mus musculus	45-49
28644409-5	2017	Quercetin also upregulated the expression of HO-1 in palmitate-treated lipid-laden microglia, and the actions of quercetin against microglia activation accompanied by IkappaBalpha degradation were abolished by a HO-1 inhibitor.	Quercetin	113-122	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	167-179
28644409-5	2017	Quercetin also upregulated the expression of HO-1 in palmitate-treated lipid-laden microglia, and the actions of quercetin against microglia activation accompanied by IkappaBalpha degradation were abolished by a HO-1 inhibitor.	Quercetin	113-122	heme oxygenase 1	Mus musculus	212-216
28644409-6	2017	Moreover, quercetin supplementation reduced the levels of inflammatory cytokines and microglia activation markers in the hypothalamus of high fat diet (HFD)-fed obese mice, which was accompanied by upregulation of HO-1.	Quercetin	10-19	heme oxygenase 1	Mus musculus	214-218
28644409-7	2017	These findings indicate that quercetin suppresses microglia-mediated inflammatory responses via the induction of HO-1, and hence protects against obesity-induced hypothalamic inflammation.	Quercetin	29-38	heme oxygenase 1	Mus musculus	113-117
28620169-0	2017	Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin.	Quercetin	111-120	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	74-79
28620169-3	2017	In present study, we have performed detailed biophysical studies for the interaction of human c-myc G-quadruplex DNA with nine representative flavonoids: Luteolin, Quercetin, Rutin, Genistein, Kaempferol, Puerarin, Hesperidin, Myricetin and Daidzein.	Quercetin	164-173	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
28620169-4	2017	We found by using fluorescence titration that Quercetin interacts with c-myc G-quadruplex DNA sequence Pu24T with highest affinity.	Quercetin	46-55	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	71-76
28620169-5	2017	This interaction was further explored by using NMR spectroscopy and we have derived the first solution structure for the complex formed between Quercetin and biologically significant c-myc promoter DNA sequence forming G-quadruplex structure.	Quercetin	144-153	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	183-188
28620169-7	2017	Furthermore, in vitro studies on HeLa cells suggested that Quercetin induces apoptosis-mediated cell death and down-regulated c-myc gene expression.	Quercetin	59-68	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	126-131
28594407-6	2017	In addition, we demonstrate that ASPP1 promoted EGR-1 in a positive feedback loop by preventing proteasome-mediated EGR-1 degradation or promoting EGR-1 nuclear import in response to anticancer natural compound Quercetin.	Quercetin	211-220	protein phosphatase 1 regulatory subunit 13B	Homo sapiens	33-38
28594407-6	2017	In addition, we demonstrate that ASPP1 promoted EGR-1 in a positive feedback loop by preventing proteasome-mediated EGR-1 degradation or promoting EGR-1 nuclear import in response to anticancer natural compound Quercetin.	Quercetin	211-220	early growth response 1	Homo sapiens	48-53
28594407-10	2017	In conclusion, our results provide new insights into EGR-1/ASPP1 regulatory loop in sensitizing Quercetin-induced apoptosis.	Quercetin	96-105	early growth response 1	Homo sapiens	53-58
28594407-10	2017	In conclusion, our results provide new insights into EGR-1/ASPP1 regulatory loop in sensitizing Quercetin-induced apoptosis.	Quercetin	96-105	protein phosphatase 1 regulatory subunit 13B	Homo sapiens	59-64
28380410-0	2017	Quercetin exhibits adjuvant activity by enhancing Th2 immune response in ovalbumin immunized mice.	Quercetin	0-9	heart and neural crest derivatives expressed 2	Mus musculus	50-53
28380410-0	2017	Quercetin exhibits adjuvant activity by enhancing Th2 immune response in ovalbumin immunized mice.	Quercetin	0-9	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	73-82
28380410-2	2017	In this study, we are reporting for the first time the in vivo immunostimulatory activity of quercetin in ovalbumin immunized Balb/c mice.	Quercetin	93-102	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	106-115
28380410-3	2017	Administration of quercetin (50mg/kg body weight) along with ovalbumin antigen showed increased ovalbumin specific serum IgG antibody titres in comparison to the control group (p&lt;0.05).	Quercetin	18-27	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	96-105
28380410-4	2017	Quercetin administration not only showed predominance of Th2 immune response by increasing the IgG1 antibody titres, but also increased the infiltration of CD11c+ dendritic cells in the mouse peritoneum and also increased LPS activated IL-1beta and nitric oxide (NO) production by peritoneal macrophages.	Quercetin	0-9	heart and neural crest derivatives expressed 2	Mus musculus	57-60
28380410-4	2017	Quercetin administration not only showed predominance of Th2 immune response by increasing the IgG1 antibody titres, but also increased the infiltration of CD11c+ dendritic cells in the mouse peritoneum and also increased LPS activated IL-1beta and nitric oxide (NO) production by peritoneal macrophages.	Quercetin	0-9	integrin subunit alpha X	Homo sapiens	156-161
28380410-4	2017	Quercetin administration not only showed predominance of Th2 immune response by increasing the IgG1 antibody titres, but also increased the infiltration of CD11c+ dendritic cells in the mouse peritoneum and also increased LPS activated IL-1beta and nitric oxide (NO) production by peritoneal macrophages.	Quercetin	0-9	interleukin 1 beta	Mus musculus	236-244
28380410-5	2017	Expression of Tbx21, GATA-3 and Oct-2 proteins also enhanced in splenocytes of quercetin administered mice.	Quercetin	79-88	T-box 21	Mus musculus	14-19
28380410-5	2017	Expression of Tbx21, GATA-3 and Oct-2 proteins also enhanced in splenocytes of quercetin administered mice.	Quercetin	79-88	GATA binding protein 3	Mus musculus	21-27
28380410-5	2017	Expression of Tbx21, GATA-3 and Oct-2 proteins also enhanced in splenocytes of quercetin administered mice.	Quercetin	79-88	POU domain, class 2, transcription factor 2	Mus musculus	32-37
28414027-6	2017	The results showed that H3K9me2/3 demethylase (JMJD2A) inhibitor, quercetin (Que) significantly attenuated the decrease of H3K9me2/3 and increase of 3beta-HSD expression induced by arsenic.	Quercetin	66-75	lysine (K)-specific demethylase 4A	Mus musculus	47-53
28414027-6	2017	The results showed that H3K9me2/3 demethylase (JMJD2A) inhibitor, quercetin (Que) significantly attenuated the decrease of H3K9me2/3 and increase of 3beta-HSD expression induced by arsenic.	Quercetin	77-80	lysine (K)-specific demethylase 4A	Mus musculus	47-53
28489572-5	2017	To identify the molecular target of quercetin, we employed a new cell line, HG3, obtained by immortalization of B-cells from a chronic lymphocytic leukaemia patient at the later stage of disease.	Quercetin	36-45	polycystin 1, transient receptor potential channel interacting pseudogene 3	Homo sapiens	76-79
28418847-0	2017	Quercetin delays postovulatory aging of mouse oocytes by regulating SIRT expression and MPF activity.	Quercetin	0-9	mesothelin	Mus musculus	88-91
28642704-0	2017	Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	82-86
28642704-2	2017	Taking advantage of protein kinase inhibitors, we proved that the effect of quercetin on 2-NBDG uptake in L6 myotubes was not through insulin signaling pathway, but through adenosine monophosphate kinase (AMPK) pathway and its downstream target p38 MAPK.	Quercetin	76-85	insulin	Homo sapiens	134-141
28642704-2	2017	Taking advantage of protein kinase inhibitors, we proved that the effect of quercetin on 2-NBDG uptake in L6 myotubes was not through insulin signaling pathway, but through adenosine monophosphate kinase (AMPK) pathway and its downstream target p38 MAPK.	Quercetin	76-85	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	173-203
28642704-2	2017	Taking advantage of protein kinase inhibitors, we proved that the effect of quercetin on 2-NBDG uptake in L6 myotubes was not through insulin signaling pathway, but through adenosine monophosphate kinase (AMPK) pathway and its downstream target p38 MAPK.	Quercetin	76-85	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	205-209
28574437-8	2017	Quercetin may inhibit cytokine production, especially in IL-6 and IL-8 and may upgrade the level of HO-1.	Quercetin	0-9	interleukin 6	Mus musculus	57-61
28574437-8	2017	Quercetin may inhibit cytokine production, especially in IL-6 and IL-8 and may upgrade the level of HO-1.	Quercetin	0-9	chemokine (C-X-C motif) ligand 15	Mus musculus	66-70
28574574-4	2017	Quercetin, a flavonoid, stimulates Na+ -K+ -2Cl- cotransporter 1 (NKCC1), which is one of the most important ion transporters regulating the cytosolic Cl- concentration ([Cl- ]c ).	Quercetin	0-9	solute carrier family 12 member 2	Homo sapiens	35-64
28574574-4	2017	Quercetin, a flavonoid, stimulates Na+ -K+ -2Cl- cotransporter 1 (NKCC1), which is one of the most important ion transporters regulating the cytosolic Cl- concentration ([Cl- ]c ).	Quercetin	0-9	solute carrier family 12 member 2	Homo sapiens	66-71
28342364-9	2017	The reduced severity of the disease in animals treated with quercetin was associated with decreased levels of TNF-alpha, IL-1beta, IL-17, and MCP-1.	Quercetin	60-69	tumor necrosis factor	Mus musculus	110-119
28342364-9	2017	The reduced severity of the disease in animals treated with quercetin was associated with decreased levels of TNF-alpha, IL-1beta, IL-17, and MCP-1.	Quercetin	60-69	interleukin 1 beta	Mus musculus	121-129
28342364-9	2017	The reduced severity of the disease in animals treated with quercetin was associated with decreased levels of TNF-alpha, IL-1beta, IL-17, and MCP-1.	Quercetin	60-69	interleukin 17A	Mus musculus	131-136
28342364-9	2017	The reduced severity of the disease in animals treated with quercetin was associated with decreased levels of TNF-alpha, IL-1beta, IL-17, and MCP-1.	Quercetin	60-69	mast cell protease 1	Mus musculus	142-147
28192862-5	2017	Unlike Mdx/Utrn-/+ mice, mdx mice receiving lifelong quercetin treatment did not exhibit improvements cardiac function.	Quercetin	53-62	dystrophin, muscular dystrophy	Mus musculus	25-28
28192862-0	2017	Long-term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice.	Quercetin	18-27	dystrophin, muscular dystrophy	Mus musculus	79-82
28498520-0	2017	Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231).	Quercetin	30-39	epidermal growth factor receptor	Homo sapiens	76-80
28498520-0	2017	Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231).	Quercetin	30-39	AKT serine/threonine kinase 1	Homo sapiens	86-89
28192862-6	2017	Similar to prior work in Mdx/Utrn-/+ mice, histological evidence of remodelling suggests that quercetin consumption may have benefited hearts of mdx mice.	Quercetin	94-103	utrophin	Mus musculus	29-33
28192862-6	2017	Similar to prior work in Mdx/Utrn-/+ mice, histological evidence of remodelling suggests that quercetin consumption may have benefited hearts of mdx mice.	Quercetin	94-103	dystrophin, muscular dystrophy	Mus musculus	145-148
28192862-9	2017	As a potential countermeasure, quercetin is a polyphenol possessing inherent anti-inflammatory and antioxidant effects that activate proliferator-activated gamma coactivator 1alpha (PGC-1alpha), increasing the abundance of mitochondrial biogenesis proteins.	Quercetin	31-40	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	182-192
28192862-15	2017	In contrast, histological analyses provided evidence that quercetin feeding was associated with decreased fibronectin and indirect damage indices (Haematoxylin and Eosin) compared with untreated mdx mice.	Quercetin	58-67	fibronectin 1	Mus musculus	106-117
28192862-16	2017	Dietary quercetin enrichment increased cardiac protein abundance of PGC-1alpha, cytochrome c, electron transport chain complexes I-V, citrate synthase, superoxide dismutase 2 and glutathione peroxidase (GPX) versus untreated mdx mice.	Quercetin	8-17	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	68-78
28192862-16	2017	Dietary quercetin enrichment increased cardiac protein abundance of PGC-1alpha, cytochrome c, electron transport chain complexes I-V, citrate synthase, superoxide dismutase 2 and glutathione peroxidase (GPX) versus untreated mdx mice.	Quercetin	8-17	dystrophin, muscular dystrophy	Mus musculus	225-228
28192862-17	2017	The protein abundance of the inflammatory markers nuclear factor-kappaB, phosphorylated nuclear factor kappa beta (P-NFkappaB) and phosphorylated nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (P-IKBalpha) was decreased by quercetin compared with untreated mdx mice, while preserving nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha( IKBalpha) compared with mdx mice.	Quercetin	259-268	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	146-228
28192862-18	2017	Furthermore, quercetin decreased transforming growth factor-beta1, cyclooxygenase-2 (COX2) and macrophage-restricted F4/80 protein (F4/80) versus untreated mdx mice.	Quercetin	13-22	prostaglandin-endoperoxide synthase 2	Mus musculus	67-83
28192862-18	2017	Furthermore, quercetin decreased transforming growth factor-beta1, cyclooxygenase-2 (COX2) and macrophage-restricted F4/80 protein (F4/80) versus untreated mdx mice.	Quercetin	13-22	prostaglandin-endoperoxide synthase 2	Mus musculus	85-89
28192862-18	2017	Furthermore, quercetin decreased transforming growth factor-beta1, cyclooxygenase-2 (COX2) and macrophage-restricted F4/80 protein (F4/80) versus untreated mdx mice.	Quercetin	13-22	adhesion G protein-coupled receptor E1	Mus musculus	117-122
28192862-18	2017	Furthermore, quercetin decreased transforming growth factor-beta1, cyclooxygenase-2 (COX2) and macrophage-restricted F4/80 protein (F4/80) versus untreated mdx mice.	Quercetin	13-22	adhesion G protein-coupled receptor E1	Mus musculus	132-137
28192862-18	2017	Furthermore, quercetin decreased transforming growth factor-beta1, cyclooxygenase-2 (COX2) and macrophage-restricted F4/80 protein (F4/80) versus untreated mdx mice.	Quercetin	13-22	dystrophin, muscular dystrophy	Mus musculus	156-159
28391159-0	2017	Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-kB/IkBalpha, p38 MAPK, and Bcl-2/Bax signaling.	Quercetin	22-31	mitogen activated protein kinase 14	Rattus norvegicus	111-114
28326454-0	2017	Quercetin and Ascorbic Acid Suppress Fructose-Induced NLRP3 Inflammasome Activation by Blocking Intracellular Shuttling of TXNIP in Human Macrophage Cell Lines.	Quercetin	0-9	NLR family pyrin domain containing 3	Homo sapiens	54-59
28326454-0	2017	Quercetin and Ascorbic Acid Suppress Fructose-Induced NLRP3 Inflammasome Activation by Blocking Intracellular Shuttling of TXNIP in Human Macrophage Cell Lines.	Quercetin	0-9	thioredoxin interacting protein	Homo sapiens	123-128
28326454-7	2017	Increased production of ROS and expression of IL-1beta, IL-18, and caspase-1 genes and proteins were observed in U937 and THP-1 cells incubated with fructose and were effectively inhibited by quercetin and ascorbic acid.	Quercetin	192-201	interleukin 1 beta	Homo sapiens	46-54
28326454-7	2017	Increased production of ROS and expression of IL-1beta, IL-18, and caspase-1 genes and proteins were observed in U937 and THP-1 cells incubated with fructose and were effectively inhibited by quercetin and ascorbic acid.	Quercetin	192-201	interleukin 18	Homo sapiens	56-61
28326454-7	2017	Increased production of ROS and expression of IL-1beta, IL-18, and caspase-1 genes and proteins were observed in U937 and THP-1 cells incubated with fructose and were effectively inhibited by quercetin and ascorbic acid.	Quercetin	192-201	caspase 1	Homo sapiens	67-76
28326454-8	2017	Intracellular shuttling of TXNIP from the nucleus into the mitochondria was detected under stimulation with fructose, which was also attenuated by antioxidants quercetin and ascorbic acid but not butylated hydroxyanisole.	Quercetin	160-169	thioredoxin interacting protein	Homo sapiens	27-32
28326454-10	2017	This study revealed that intracellular TXNIP protein is a critical regulator of activation of the fructose-induced NLRP3 inflammasome, which can be effectively blocked by the antioxidants quercetin and ascorbic acid.	Quercetin	188-197	thioredoxin interacting protein	Homo sapiens	39-44
28326454-10	2017	This study revealed that intracellular TXNIP protein is a critical regulator of activation of the fructose-induced NLRP3 inflammasome, which can be effectively blocked by the antioxidants quercetin and ascorbic acid.	Quercetin	188-197	NLR family pyrin domain containing 3	Homo sapiens	115-120
28391159-6	2017	Furthermore, treatment with quercetin 5-15mg/kg inhibited the activation of NF-kappaB in a dose-dependent manner via inhibition of IkBalpha degradation and decreased the expression of p38 MAPK by inhibiting its phosphorylation.	Quercetin	28-37	mitogen activated protein kinase 14	Rattus norvegicus	184-187
28391159-7	2017	Additionally, in a dose-dependent manner, quercetin down-regulated Bax, up-regulated Bcl-2, and subsequently inhibited caspase-3 activation.	Quercetin	42-51	BCL2 associated X, apoptosis regulator	Rattus norvegicus	67-70
28391159-7	2017	Additionally, in a dose-dependent manner, quercetin down-regulated Bax, up-regulated Bcl-2, and subsequently inhibited caspase-3 activation.	Quercetin	42-51	BCL2, apoptosis regulator	Rattus norvegicus	85-90
28391159-7	2017	Additionally, in a dose-dependent manner, quercetin down-regulated Bax, up-regulated Bcl-2, and subsequently inhibited caspase-3 activation.	Quercetin	42-51	caspase 3	Rattus norvegicus	119-128
28391159-8	2017	Moreover, quercetin regulated inflammation factors and hepatic stellate cells (HSCs)-activation markers, such as TNF-alpha, IL-6, IL-1beta, Cox-2, TGF-beta, alpha-SMA, Colla1, Colla2, TIMP-1, MMP-1, and desmin.	Quercetin	10-19	tumor necrosis factor	Rattus norvegicus	113-122
28391159-0	2017	Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-kB/IkBalpha, p38 MAPK, and Bcl-2/Bax signaling.	Quercetin	22-31	BCL2, apoptosis regulator	Rattus norvegicus	125-130
28391159-8	2017	Moreover, quercetin regulated inflammation factors and hepatic stellate cells (HSCs)-activation markers, such as TNF-alpha, IL-6, IL-1beta, Cox-2, TGF-beta, alpha-SMA, Colla1, Colla2, TIMP-1, MMP-1, and desmin.	Quercetin	10-19	interleukin 6	Rattus norvegicus	124-128
28391159-0	2017	Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-kB/IkBalpha, p38 MAPK, and Bcl-2/Bax signaling.	Quercetin	22-31	BCL2 associated X, apoptosis regulator	Rattus norvegicus	131-134
28391159-8	2017	Moreover, quercetin regulated inflammation factors and hepatic stellate cells (HSCs)-activation markers, such as TNF-alpha, IL-6, IL-1beta, Cox-2, TGF-beta, alpha-SMA, Colla1, Colla2, TIMP-1, MMP-1, and desmin.	Quercetin	10-19	interleukin 1 beta	Rattus norvegicus	130-138
28391159-8	2017	Moreover, quercetin regulated inflammation factors and hepatic stellate cells (HSCs)-activation markers, such as TNF-alpha, IL-6, IL-1beta, Cox-2, TGF-beta, alpha-SMA, Colla1, Colla2, TIMP-1, MMP-1, and desmin.	Quercetin	10-19	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	140-145
28391159-5	2017	We demonstrated that quercetin exhibited in-vivo hepatoprotective and anti-fibrogenic effects against CCl4-induced liver injury by improving the pathological manifestations, thereby reducing the activities of serum total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and decreasing the serum levels of hyaluronic acid (HA), laminin (LN), type IV collagen (IV-C) and procollagen III peptide (PIIIP).	Quercetin	21-30	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	271-297
28391159-8	2017	Moreover, quercetin regulated inflammation factors and hepatic stellate cells (HSCs)-activation markers, such as TNF-alpha, IL-6, IL-1beta, Cox-2, TGF-beta, alpha-SMA, Colla1, Colla2, TIMP-1, MMP-1, and desmin.	Quercetin	10-19	transforming growth factor, beta 1	Rattus norvegicus	147-155
28391159-8	2017	Moreover, quercetin regulated inflammation factors and hepatic stellate cells (HSCs)-activation markers, such as TNF-alpha, IL-6, IL-1beta, Cox-2, TGF-beta, alpha-SMA, Colla1, Colla2, TIMP-1, MMP-1, and desmin.	Quercetin	10-19	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	184-190
28391159-5	2017	We demonstrated that quercetin exhibited in-vivo hepatoprotective and anti-fibrogenic effects against CCl4-induced liver injury by improving the pathological manifestations, thereby reducing the activities of serum total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and decreasing the serum levels of hyaluronic acid (HA), laminin (LN), type IV collagen (IV-C) and procollagen III peptide (PIIIP).	Quercetin	21-30	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	299-302
31682374-0	2017	Effect of quercetin on secretion and gene expression of leptin in breast cancer.	Quercetin	10-19	leptin	Homo sapiens	56-62
28391159-8	2017	Moreover, quercetin regulated inflammation factors and hepatic stellate cells (HSCs)-activation markers, such as TNF-alpha, IL-6, IL-1beta, Cox-2, TGF-beta, alpha-SMA, Colla1, Colla2, TIMP-1, MMP-1, and desmin.	Quercetin	10-19	matrix metallopeptidase 1	Rattus norvegicus	192-197
28391159-8	2017	Moreover, quercetin regulated inflammation factors and hepatic stellate cells (HSCs)-activation markers, such as TNF-alpha, IL-6, IL-1beta, Cox-2, TGF-beta, alpha-SMA, Colla1, Colla2, TIMP-1, MMP-1, and desmin.	Quercetin	10-19	desmin	Rattus norvegicus	203-209
28391159-10	2017	The anti-fibrotic mechanisms of quercetin might be associated with its ability to regulate NF-kB/IkBalpha, p38 MAPK anti-inflammation signaling pathways to inhibit inflammation, and regulate Bcl-2/Bax anti-apoptosis signaling pathway to prevent liver cell apoptosis.	Quercetin	32-41	mitogen activated protein kinase 14	Rattus norvegicus	107-110
28391159-10	2017	The anti-fibrotic mechanisms of quercetin might be associated with its ability to regulate NF-kB/IkBalpha, p38 MAPK anti-inflammation signaling pathways to inhibit inflammation, and regulate Bcl-2/Bax anti-apoptosis signaling pathway to prevent liver cell apoptosis.	Quercetin	32-41	BCL2, apoptosis regulator	Rattus norvegicus	191-196
28391159-10	2017	The anti-fibrotic mechanisms of quercetin might be associated with its ability to regulate NF-kB/IkBalpha, p38 MAPK anti-inflammation signaling pathways to inhibit inflammation, and regulate Bcl-2/Bax anti-apoptosis signaling pathway to prevent liver cell apoptosis.	Quercetin	32-41	BCL2 associated X, apoptosis regulator	Rattus norvegicus	197-200
27714811-0	2017	Inhibitory Effects of Quercetin on Progression of Human Choriocarcinoma Cells Are Mediated Through PI3K/AKT and MAPK Signal Transduction Cascades.	Quercetin	22-31	AKT serine/threonine kinase 1	Homo sapiens	104-107
27714811-0	2017	Inhibitory Effects of Quercetin on Progression of Human Choriocarcinoma Cells Are Mediated Through PI3K/AKT and MAPK Signal Transduction Cascades.	Quercetin	22-31	mitogen-activated protein kinase 3	Homo sapiens	112-116
27714811-5	2017	Further, quercetin inhibited phosphorylation of AKT, P70S6K and S6 proteins whereas, it increased phosphorylation of ERK1/2, P38, JNK and P90RSK proteins in JAR and JEG3 cells.	Quercetin	9-18	AKT serine/threonine kinase 1	Homo sapiens	48-51
27714811-5	2017	Further, quercetin inhibited phosphorylation of AKT, P70S6K and S6 proteins whereas, it increased phosphorylation of ERK1/2, P38, JNK and P90RSK proteins in JAR and JEG3 cells.	Quercetin	9-18	ribosomal protein S6 kinase B1	Homo sapiens	53-59
27714811-5	2017	Further, quercetin inhibited phosphorylation of AKT, P70S6K and S6 proteins whereas, it increased phosphorylation of ERK1/2, P38, JNK and P90RSK proteins in JAR and JEG3 cells.	Quercetin	9-18	mitogen-activated protein kinase 3	Homo sapiens	117-123
27714811-5	2017	Further, quercetin inhibited phosphorylation of AKT, P70S6K and S6 proteins whereas, it increased phosphorylation of ERK1/2, P38, JNK and P90RSK proteins in JAR and JEG3 cells.	Quercetin	9-18	mitogen-activated protein kinase 1	Homo sapiens	125-128
27714811-5	2017	Further, quercetin inhibited phosphorylation of AKT, P70S6K and S6 proteins whereas, it increased phosphorylation of ERK1/2, P38, JNK and P90RSK proteins in JAR and JEG3 cells.	Quercetin	9-18	mitogen-activated protein kinase 8	Homo sapiens	130-133
27714811-5	2017	Further, quercetin inhibited phosphorylation of AKT, P70S6K and S6 proteins whereas, it increased phosphorylation of ERK1/2, P38, JNK and P90RSK proteins in JAR and JEG3 cells.	Quercetin	9-18	ribosomal protein S6 kinase A1	Homo sapiens	138-144
27714811-6	2017	The decrease in viability of choriocarcinoma cells treated with quercetin was confirmed by using combinations of quercetin and pharmacological inhibitors of the PI3K and MAPK signaling pathways.	Quercetin	64-73	mitogen-activated protein kinase 3	Homo sapiens	170-174
27714811-6	2017	The decrease in viability of choriocarcinoma cells treated with quercetin was confirmed by using combinations of quercetin and pharmacological inhibitors of the PI3K and MAPK signaling pathways.	Quercetin	113-122	mitogen-activated protein kinase 3	Homo sapiens	170-174
27714811-8	2017	Collectively, these results suggest that quercetin prevents development of choriocarcinoma and may be a valuable therapeutic agent for treatment of choriocarcinoma through its regulation of PI3K and MAPK signal transduction pathways.	Quercetin	41-50	mitogen-activated protein kinase 3	Homo sapiens	199-203
28376279-3	2017	Western blot analysis revealed that quercetin significantly induced the activation of two major cell survival kinases, protein kinase D1 (PKD1) and Akt in MN9D dopaminergic neuronal cells.	Quercetin	36-45	protein kinase D1	Mus musculus	119-136
28376279-3	2017	Western blot analysis revealed that quercetin significantly induced the activation of two major cell survival kinases, protein kinase D1 (PKD1) and Akt in MN9D dopaminergic neuronal cells.	Quercetin	36-45	protein kinase D1	Mus musculus	138-142
28376279-3	2017	Western blot analysis revealed that quercetin significantly induced the activation of two major cell survival kinases, protein kinase D1 (PKD1) and Akt in MN9D dopaminergic neuronal cells.	Quercetin	36-45	thymoma viral proto-oncogene 1	Mus musculus	148-151
28376279-4	2017	Furthermore, pharmacological inhibition or siRNA knockdown of PKD1 blocked the activation of Akt, suggesting that PKD1 acts as an upstream regulator of Akt in quercetin-mediated neuroprotective signaling.	Quercetin	159-168	protein kinase D1	Mus musculus	62-66
28376279-4	2017	Furthermore, pharmacological inhibition or siRNA knockdown of PKD1 blocked the activation of Akt, suggesting that PKD1 acts as an upstream regulator of Akt in quercetin-mediated neuroprotective signaling.	Quercetin	159-168	thymoma viral proto-oncogene 1	Mus musculus	93-96
28376279-4	2017	Furthermore, pharmacological inhibition or siRNA knockdown of PKD1 blocked the activation of Akt, suggesting that PKD1 acts as an upstream regulator of Akt in quercetin-mediated neuroprotective signaling.	Quercetin	159-168	protein kinase D1	Mus musculus	114-118
28376279-4	2017	Furthermore, pharmacological inhibition or siRNA knockdown of PKD1 blocked the activation of Akt, suggesting that PKD1 acts as an upstream regulator of Akt in quercetin-mediated neuroprotective signaling.	Quercetin	159-168	thymoma viral proto-oncogene 1	Mus musculus	152-155
28376279-5	2017	Quercetin also enhanced cAMP response-element binding protein phosphorylation and expression of the cAMP response-element binding protein target gene brain-derived neurotrophic factor.	Quercetin	0-9	brain derived neurotrophic factor	Mus musculus	150-183
28376279-10	2017	Together, our findings demonstrate that quercetin activates the PKD1-Akt cell survival signaling axis and suggest that further exploration of quercetin as a promising neuroprotective agent for treating PD may offer clinical benefits.	Quercetin	40-49	protein kinase D1	Mus musculus	64-68
28376279-10	2017	Together, our findings demonstrate that quercetin activates the PKD1-Akt cell survival signaling axis and suggest that further exploration of quercetin as a promising neuroprotective agent for treating PD may offer clinical benefits.	Quercetin	40-49	thymoma viral proto-oncogene 1	Mus musculus	69-72
28376279-10	2017	Together, our findings demonstrate that quercetin activates the PKD1-Akt cell survival signaling axis and suggest that further exploration of quercetin as a promising neuroprotective agent for treating PD may offer clinical benefits.	Quercetin	142-151	protein kinase D1	Mus musculus	64-68
28376279-10	2017	Together, our findings demonstrate that quercetin activates the PKD1-Akt cell survival signaling axis and suggest that further exploration of quercetin as a promising neuroprotective agent for treating PD may offer clinical benefits.	Quercetin	142-151	thymoma viral proto-oncogene 1	Mus musculus	69-72
28058739-1	2017	This study aims to investigate the interaction between 3 flavonoids (quercetin, apigenin, and naringenin) and fat mass and obesity-associated protein by fluorescence, ultraviolet-visible absorption spectroscopy, and molecular modeling.	Quercetin	69-78	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	110-149
30087790-3	2017	To address the anti-inflammatory role of flavonoids, in the present study, we investigated the effects of the flavonoids quercetin and vitexin on the stimulus-induced nitric oxide (NO), TNF-alpha, and MPO productions in human neutrophils.	Quercetin	121-130	myeloperoxidase	Homo sapiens	201-204
30087790-11	2017	Both quercetin and vitexin significantly inhibited TNF-alpha, NO, and MPO productions in human neutrophils (P &lt; 0.001).	Quercetin	5-14	tumor necrosis factor	Homo sapiens	51-60
30087790-11	2017	Both quercetin and vitexin significantly inhibited TNF-alpha, NO, and MPO productions in human neutrophils (P &lt; 0.001).	Quercetin	5-14	myeloperoxidase	Homo sapiens	70-73
31682374-1	2017	OBJECTIVE: To investigate the possible inhibitory action of pure quercetin on secretion and gene expression of leptin in the T47D breast cancer cell line.	Quercetin	65-74	leptin	Homo sapiens	111-117
31682374-7	2017	Data analysis of real-time PCR showed that with increases in quercetin concentration, a decreasing trend was seen in mRNA levels of leptin of treated cells compared with the control cells (P &lt; 0.05).	Quercetin	61-70	leptin	Homo sapiens	132-138
31682374-9	2017	CONCLUSION: Quercetin significantly inhibits the growth of T47D cells through inhibition of leptin secretion and gene expression in T47D breast cancer cells.	Quercetin	12-21	leptin	Homo sapiens	92-98
28414916-3	2017	Upon screening several natural chemicals, we found that a dietary flavonoid, quercetin, significantly suppresses Wnt16 expression in activated fibroblasts.	Quercetin	77-86	Wnt family member 16	Homo sapiens	113-118
28615097-8	2017	Results Quercetin significantly reduced the pathological changes of lung tissues, lowered PaCO2 while increased PaO2 and D/W ratio, down-regulated the expressions of iNOS, TNF-alpha, IL-1beta while up-regulated the expressions of IL-4 and IL-10 in SW-ALI mice.	Quercetin	8-17	nitric oxide synthase 2, inducible	Mus musculus	166-170
28615097-8	2017	Results Quercetin significantly reduced the pathological changes of lung tissues, lowered PaCO2 while increased PaO2 and D/W ratio, down-regulated the expressions of iNOS, TNF-alpha, IL-1beta while up-regulated the expressions of IL-4 and IL-10 in SW-ALI mice.	Quercetin	8-17	tumor necrosis factor	Mus musculus	172-181
28615097-8	2017	Results Quercetin significantly reduced the pathological changes of lung tissues, lowered PaCO2 while increased PaO2 and D/W ratio, down-regulated the expressions of iNOS, TNF-alpha, IL-1beta while up-regulated the expressions of IL-4 and IL-10 in SW-ALI mice.	Quercetin	8-17	interleukin 1 beta	Mus musculus	183-191
28615097-8	2017	Results Quercetin significantly reduced the pathological changes of lung tissues, lowered PaCO2 while increased PaO2 and D/W ratio, down-regulated the expressions of iNOS, TNF-alpha, IL-1beta while up-regulated the expressions of IL-4 and IL-10 in SW-ALI mice.	Quercetin	8-17	interleukin 4	Mus musculus	230-234
28615097-8	2017	Results Quercetin significantly reduced the pathological changes of lung tissues, lowered PaCO2 while increased PaO2 and D/W ratio, down-regulated the expressions of iNOS, TNF-alpha, IL-1beta while up-regulated the expressions of IL-4 and IL-10 in SW-ALI mice.	Quercetin	8-17	interleukin 10	Mus musculus	239-244
28579828-10	2017	Our results show that quercetin suppresses prenatal stress-induced pro-inflammatory marker (interleukin 1 beta) levels, subsequently attenuating febrile seizures.	Quercetin	22-31	interleukin 1 beta	Rattus norvegicus	92-110
28347707-0	2017	The involvement of sirtuin 1 and heme oxygenase 1 in the hepatoprotective effects of quercetin against carbon tetrachloride-induced sub-chronic liver toxicity in rats.	Quercetin	85-94	sirtuin 1	Rattus norvegicus	19-28
28336457-0	2017	Synergistic inhibition of migration and invasion of breast cancer cells by dual docetaxel/quercetin-loaded nanoparticles via Akt/MMP-9 pathway.	Quercetin	90-99	thymoma viral proto-oncogene 1	Mus musculus	125-128
28336457-0	2017	Synergistic inhibition of migration and invasion of breast cancer cells by dual docetaxel/quercetin-loaded nanoparticles via Akt/MMP-9 pathway.	Quercetin	90-99	matrix metallopeptidase 9	Mus musculus	129-134
28336457-2	2017	In this study, an Akt inhibitor (quercetin, Qu) was co-delivered with a chemotherapeutic agent (docetaxel, DTX) by using hyaluronic acid (HA)-modified nanoparticles (NPs) as vectors to block metastasis.	Quercetin	33-42	thymoma viral proto-oncogene 1	Mus musculus	18-21
29069736-0	2017	A novel synthetic derivative of quercetin, 8-trifluoromethyl-3,5,7,3",4"-O-pentamethyl-quercetin, inhibits bladder cancer growth by targeting the AMPK/mTOR signaling pathway.	Quercetin	32-41	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	146-150
29069736-0	2017	A novel synthetic derivative of quercetin, 8-trifluoromethyl-3,5,7,3",4"-O-pentamethyl-quercetin, inhibits bladder cancer growth by targeting the AMPK/mTOR signaling pathway.	Quercetin	32-41	mechanistic target of rapamycin kinase	Homo sapiens	151-155
29069736-3	2017	In our previous study, we elucidated that quercetin activates AMPK pathway which is the major mechanism for its unique anticancer effect in bladder cancer.	Quercetin	42-51	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	62-66
29069736-11	2017	These results demonstrated that the fluorinated quercetin derivative TFQ inhibits bladder cancer cell growth through the AMPK/mTOR pathway.	Quercetin	48-57	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	121-125
29069736-11	2017	These results demonstrated that the fluorinated quercetin derivative TFQ inhibits bladder cancer cell growth through the AMPK/mTOR pathway.	Quercetin	48-57	mechanistic target of rapamycin kinase	Homo sapiens	126-130
28508104-5	2017	Quercetin inhibited MSU-induced mechanical hyperalgesia, leukocyte recruitment, TNFalpha and IL-1beta production, superoxide anion production, inflammasome activation, decrease of antioxidants levels, NFkappaB activation, and inflammasome components mRNA expression.	Quercetin	0-9	tumor necrosis factor	Mus musculus	80-88
28508104-5	2017	Quercetin inhibited MSU-induced mechanical hyperalgesia, leukocyte recruitment, TNFalpha and IL-1beta production, superoxide anion production, inflammasome activation, decrease of antioxidants levels, NFkappaB activation, and inflammasome components mRNA expression.	Quercetin	0-9	interleukin 1 beta	Mus musculus	93-101
28508104-5	2017	Quercetin inhibited MSU-induced mechanical hyperalgesia, leukocyte recruitment, TNFalpha and IL-1beta production, superoxide anion production, inflammasome activation, decrease of antioxidants levels, NFkappaB activation, and inflammasome components mRNA expression.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	201-209
28258480-0	2017	The anti-HSV-1 effect of quercetin is dependent on the suppression of TLR-3 in Raw 264.7 cells.	Quercetin	25-34	toll-like receptor 3	Mus musculus	70-75
28258480-8	2017	Interestingly, quercetin specifically suppressed the expression of TLR-3, and this led to the inhibitions of inflammatory transcriptional factors (NF-kappaB and IRF3).	Quercetin	15-24	toll like receptor 3	Homo sapiens	67-72
28258480-8	2017	Interestingly, quercetin specifically suppressed the expression of TLR-3, and this led to the inhibitions of inflammatory transcriptional factors (NF-kappaB and IRF3).	Quercetin	15-24	nuclear factor kappa B subunit 1	Homo sapiens	147-156
28258480-8	2017	Interestingly, quercetin specifically suppressed the expression of TLR-3, and this led to the inhibitions of inflammatory transcriptional factors (NF-kappaB and IRF3).	Quercetin	15-24	interferon regulatory factor 3	Homo sapiens	161-165
28258480-9	2017	These findings suggest that the anti-HSV-1 effects of quercetin are related to the suppression of TLR-3 dependent inflammatory responses in Raw 264.7 cells.	Quercetin	54-63	toll-like receptor 3	Mus musculus	98-103
28347707-0	2017	The involvement of sirtuin 1 and heme oxygenase 1 in the hepatoprotective effects of quercetin against carbon tetrachloride-induced sub-chronic liver toxicity in rats.	Quercetin	85-94	heme oxygenase 1	Rattus norvegicus	33-49
28347707-8	2017	Concomitant treatment of rats with quercetin downregulated SIRT1 expression and ameliorated the hepatotoxic effects of CTC.	Quercetin	35-44	sirtuin 1	Rattus norvegicus	59-64
28347707-10	2017	Collectively, these results suggest that the antioxidant and cytoprotective effects of quercetin in CTC treated rats were SIRT1 mediated and less dependent on HO-1.	Quercetin	87-96	sirtuin 1	Rattus norvegicus	122-127
28347707-10	2017	Collectively, these results suggest that the antioxidant and cytoprotective effects of quercetin in CTC treated rats were SIRT1 mediated and less dependent on HO-1.	Quercetin	87-96	heme oxygenase 1	Rattus norvegicus	159-163
28617535-9	2017	Targeting thyroid hormone restoration, inhibition of ACE and GSK3beta via PI3K/AKT signaling pathway using LA, Resveratrol and Quercetin are potential novel therapeutic approaches for developing pharmaceuticals that could make significance in MS treatment.	Quercetin	127-136	angiotensin I converting enzyme	Homo sapiens	53-56
28617535-9	2017	Targeting thyroid hormone restoration, inhibition of ACE and GSK3beta via PI3K/AKT signaling pathway using LA, Resveratrol and Quercetin are potential novel therapeutic approaches for developing pharmaceuticals that could make significance in MS treatment.	Quercetin	127-136	glycogen synthase kinase 3 beta	Homo sapiens	61-69
28617535-9	2017	Targeting thyroid hormone restoration, inhibition of ACE and GSK3beta via PI3K/AKT signaling pathway using LA, Resveratrol and Quercetin are potential novel therapeutic approaches for developing pharmaceuticals that could make significance in MS treatment.	Quercetin	127-136	AKT serine/threonine kinase 1	Homo sapiens	79-82
28000380-0	2017	Quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1-alpha, TGF-beta, Smad-2, and AKT pathways.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Rattus norvegicus	109-112
28000380-0	2017	Quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1-alpha, TGF-beta, Smad-2, and AKT pathways.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	114-124
28000380-0	2017	Quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1-alpha, TGF-beta, Smad-2, and AKT pathways.	Quercetin	0-9	transforming growth factor, beta 1	Rattus norvegicus	126-134
28000380-0	2017	Quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1-alpha, TGF-beta, Smad-2, and AKT pathways.	Quercetin	0-9	SMAD family member 2	Rattus norvegicus	136-142
28000380-0	2017	Quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1-alpha, TGF-beta, Smad-2, and AKT pathways.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	148-151
27794544-7	2017	To investigate this, 200 muM quercetin, an Hsp70 inhibitor, was used to inhibit the expression of Hsp70 2 h before heat stress.	Quercetin	29-38	heat shock protein family A (Hsp70) member 2	Gallus gallus	43-48
28407238-0	2017	Quercetin, Hyperin, and Chlorogenic Acid Improve Endothelial Function by Antioxidant, Antiinflammatory, and ACE Inhibitory Effects.	Quercetin	0-9	angiotensin I converting enzyme	Homo sapiens	108-111
28490163-0	2017	Effects of Quercetin and Mannitol on Erythropoietin Levels in Rats Following Acute Severe Traumatic Brain Injury.	Quercetin	11-20	erythropoietin	Rattus norvegicus	37-51
28490163-1	2017	OBJECTIVE: The aim of this study to investigate the normal values of erythropoietin (EPO) and neuroprotective effects of quercetin and mannitol on EPO and hematocrit levels after acute severe traumatic brain injury (TBI) in rat model.	Quercetin	121-130	erythropoietin	Rattus norvegicus	147-150
28447754-3	2017	Inhibition of Hsp70 expression in quercetin treatment groups was detected, and suggested that Hsp70 expression was inhibited significantly.	Quercetin	34-43	heat shock protein family A (Hsp70) member 2	Gallus gallus	14-19
28447754-3	2017	Inhibition of Hsp70 expression in quercetin treatment groups was detected, and suggested that Hsp70 expression was inhibited significantly.	Quercetin	34-43	heat shock protein family A (Hsp70) member 2	Gallus gallus	94-99
28447754-5	2017	In the Hsp70 low expression group, levels of these enzymes were elevated significantly compared with HS group, quercetin alone didn"t elevate the level of these enzymes, The Hsp70 low expression group had twofold greater apoptosis compared with the HS group after 5 h of HS which was consistent with the results of Cleaved caspase-3 protein, no obvious apoptosis was detected in quercetin group.	Quercetin	379-388	heat shock protein family A (Hsp70) member 2	Gallus gallus	7-12
28447754-5	2017	In the Hsp70 low expression group, levels of these enzymes were elevated significantly compared with HS group, quercetin alone didn"t elevate the level of these enzymes, The Hsp70 low expression group had twofold greater apoptosis compared with the HS group after 5 h of HS which was consistent with the results of Cleaved caspase-3 protein, no obvious apoptosis was detected in quercetin group.	Quercetin	379-388	heat shock protein family A (Hsp70) member 2	Gallus gallus	174-179
27794544-7	2017	To investigate this, 200 muM quercetin, an Hsp70 inhibitor, was used to inhibit the expression of Hsp70 2 h before heat stress.	Quercetin	29-38	heat shock protein family A (Hsp70) member 2	Gallus gallus	98-103
27794544-8	2017	Quercetin pre-treatment was observed to suppress the expression of Hsp70 as well the protective function of co-enzyme Q10 at 5 h of heat stress.	Quercetin	0-9	heat shock protein family A (Hsp70) member 2	Gallus gallus	67-72
28237818-3	2017	Here we report that quercetin, a plant flavonoid, which is known for its neuroprotective effect, reversibly inhibits homomeric rat ASIC1a, ASIC2a and ASIC3 with an IC50 of about 2microM.	Quercetin	20-29	acid sensing ion channel subunit 3	Rattus norvegicus	150-155
27634381-11	2017	Quercetin significantly reduced the levels of blood insulin, interleukin 1beta, IL-6, and tumor necrosis factor alpha.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	61-78
27634381-11	2017	Quercetin significantly reduced the levels of blood insulin, interleukin 1beta, IL-6, and tumor necrosis factor alpha.	Quercetin	0-9	interleukin 6	Rattus norvegicus	80-84
27634381-11	2017	Quercetin significantly reduced the levels of blood insulin, interleukin 1beta, IL-6, and tumor necrosis factor alpha.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	90-117
29082699-7	2017	Expressions of Bal-2, Bal-xL, p-TAK1, p-MKK4/7, p-JNK decreased in BIU-87 cells after treatment with quercetin.	Quercetin	101-110	poly(ADP-ribose) polymerase family member 14	Homo sapiens	15-20
29082699-7	2017	Expressions of Bal-2, Bal-xL, p-TAK1, p-MKK4/7, p-JNK decreased in BIU-87 cells after treatment with quercetin.	Quercetin	101-110	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	32-36
29082699-7	2017	Expressions of Bal-2, Bal-xL, p-TAK1, p-MKK4/7, p-JNK decreased in BIU-87 cells after treatment with quercetin.	Quercetin	101-110	mitogen-activated protein kinase 8	Homo sapiens	50-53
28277581-0	2017	Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling.	Quercetin	33-42	ubiquitin conjugating enzyme E2 S	Homo sapiens	96-101
28277581-3	2017	This study analyzed the invasiveness activation by ubiquitin E2S ligase (UBE2S) through EMT signaling and inhibition by luteolin and quercetin.	Quercetin	133-142	ubiquitin conjugating enzyme E2 S	Homo sapiens	51-71
28277581-3	2017	This study analyzed the invasiveness activation by ubiquitin E2S ligase (UBE2S) through EMT signaling and inhibition by luteolin and quercetin.	Quercetin	133-142	ubiquitin conjugating enzyme E2 S	Homo sapiens	73-78
28277581-6	2017	Luteolin and quercetin significantly inhibited UBE2S expression.	Quercetin	13-22	ubiquitin conjugating enzyme E2 S	Homo sapiens	47-52
28277581-8	2017	Our findings suggest that high UBE2S in malignant cancers contributes to cell motility through EMT signaling and is reversed by luteolin and quercetin.	Quercetin	141-150	ubiquitin conjugating enzyme E2 S	Homo sapiens	31-36
28277581-10	2017	These results show the metastatic inhibition of cervical cancer by luteolin and quercetin through reducing UBE2S expression, and provide a functional role for UBE2S in the motility of cervical cancer.	Quercetin	80-89	ubiquitin conjugating enzyme E2 S	Homo sapiens	107-112
28435263-1	2017	A drug delivery system of quercetin (QU)-encapsulated liposomes (LS) grafted with RMP-7, a bradykinin analog, and lactoferrin (Lf) was developed to permeate the blood-brain barrier (BBB) and rescue degenerated neurons, acting as an Alzheimer"s disease (AD) pharmacotherapy.	Quercetin	26-35	kininogen 1	Homo sapiens	91-101
28232125-0	2017	In vitro inhibition of human CYP2E1 and CYP3A by quercetin and myricetin in hepatic microsomes is not gender dependent.	Quercetin	49-58	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	29-35
28232125-0	2017	In vitro inhibition of human CYP2E1 and CYP3A by quercetin and myricetin in hepatic microsomes is not gender dependent.	Quercetin	49-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	40-45
28232125-2	2017	Activities of CYP2E1 and CYP3A were measured in the presence of quercetin, myricetin, or isorhamnetin in hepatic microsomal pools from male and female donors.	Quercetin	64-73	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	14-20
28232125-2	2017	Activities of CYP2E1 and CYP3A were measured in the presence of quercetin, myricetin, or isorhamnetin in hepatic microsomal pools from male and female donors.	Quercetin	64-73	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	25-30
28232125-4	2017	Quercetin, but not myricetin or isorhamnetin, competitively inhibited PNPH activity in human recombinant cDNA-expressed CYP2E1 with the Ki=52.1+-6.31muM.	Quercetin	0-9	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	120-126
28232125-6	2017	Quercetin inhibited BFC activity in human recombinant cDNA-expressed CYP3A4 competitively with the Ki=15.4+-1.52muM, and myricetin - noncompetitively with the Ki=74.6+-7.99muM.	Quercetin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	69-75
28188387-0	2017	Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	81-86
28188387-0	2017	Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	87-92
28192878-0	2017	Neuroprotective effects of pretreatment with quercetin as assessed by acetylcholinesterase assay and behavioral testing in poloxamer-407 induced hyperlipidemic rats.	Quercetin	45-54	acetylcholinesterase	Rattus norvegicus	70-90
28192878-10	2017	Pretreatment with quercetin and simvastatin treatment in the hyperlipidemic groups significantly (P&lt;0.05) increased AChE activity compared with the hyperlipidemic group.	Quercetin	18-27	acetylcholinesterase	Rattus norvegicus	119-123
28135601-0	2017	Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme.	Quercetin	15-24	albumin	Homo sapiens	90-103
28192878-11	2017	Our results thus suggest that quercetin may prevent memory impairment, alter lipid metabolism, and modulate AChE activity in an experimental model of hyperlipidemia.	Quercetin	30-39	acetylcholinesterase	Rattus norvegicus	108-112
28135601-0	2017	Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme.	Quercetin	15-24	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	122-128
28494841-3	2017	Quercetin did not influence CYP1A1 in untreated rats but inhibited BaP-mediated CYP1A induction on the transcriptional level decreasing positive input (AhR functional activity) and increasing negative input (AhRR/ARNT expression and Oct-1 and C/EBP functional activities).	Quercetin	0-9	aryl hydrocarbon receptor	Rattus norvegicus	152-155
28135601-6	2017	Herein, we demonstrate that each tested flavonoid metabolite can bind to human serum albumin (HSA) with high affinity, some with similar or even higher affinity than quercetin itself.	Quercetin	166-175	albumin	Homo sapiens	79-92
28494841-3	2017	Quercetin did not influence CYP1A1 in untreated rats but inhibited BaP-mediated CYP1A induction on the transcriptional level decreasing positive input (AhR functional activity) and increasing negative input (AhRR/ARNT expression and Oct-1 and C/EBP functional activities).	Quercetin	0-9	solute carrier family 22 member 1	Rattus norvegicus	233-238
28494841-3	2017	Quercetin did not influence CYP1A1 in untreated rats but inhibited BaP-mediated CYP1A induction on the transcriptional level decreasing positive input (AhR functional activity) and increasing negative input (AhRR/ARNT expression and Oct-1 and C/EBP functional activities).	Quercetin	0-9	aryl-hydrocarbon receptor repressor	Rattus norvegicus	208-212
28494841-3	2017	Quercetin did not influence CYP1A1 in untreated rats but inhibited BaP-mediated CYP1A induction on the transcriptional level decreasing positive input (AhR functional activity) and increasing negative input (AhRR/ARNT expression and Oct-1 and C/EBP functional activities).	Quercetin	0-9	aryl hydrocarbon receptor nuclear translocator	Rattus norvegicus	213-217
28494841-3	2017	Quercetin did not influence CYP1A1 in untreated rats but inhibited BaP-mediated CYP1A induction on the transcriptional level decreasing positive input (AhR functional activity) and increasing negative input (AhRR/ARNT expression and Oct-1 and C/EBP functional activities).	Quercetin	0-9	CCAAT/enhancer binding protein gamma	Rattus norvegicus	243-248
28235721-2	2017	We found that quercetin, fisetin, and some related flavonoid derivatives could inhibit human ether-a-go-go-related gene (hERG) K+ channels.	Quercetin	14-23	ETS transcription factor ERG	Homo sapiens	121-125
28235721-4	2017	For the first time, we demonstrate that quercetin and fisetin (Fise) are potent hERG current blockers.	Quercetin	40-49	ETS transcription factor ERG	Homo sapiens	80-84
28235721-8	2017	CONCLUSION: These results suggest that quercetin, fisetin, and luteolin are potent hERG K+ channel inhibitors and reveal the structure-activity relationship of natural flavonoids.	Quercetin	39-48	ETS transcription factor ERG	Homo sapiens	83-87
28259895-8	2017	Further study suggested that quercetin nanoparticle accelerated the cleavage of caspase-9, caspase-3, and induced the up-releasing of cytochrome c (Cyto-c), contributing to apoptosis in liver cancer cells.	Quercetin	29-38	caspase 9	Homo sapiens	80-89
28110104-5	2017	Immunohistochemistry showed that oral administration of quercetin increased nestin-, DCX-, BrdU/DCX-, and BrdU/NeuN-positive cells in the dentate gyrus of mice.	Quercetin	56-65	doublecortin	Mus musculus	85-88
28259895-8	2017	Further study suggested that quercetin nanoparticle accelerated the cleavage of caspase-9, caspase-3, and induced the up-releasing of cytochrome c (Cyto-c), contributing to apoptosis in liver cancer cells.	Quercetin	29-38	caspase 3	Homo sapiens	91-100
28259895-8	2017	Further study suggested that quercetin nanoparticle accelerated the cleavage of caspase-9, caspase-3, and induced the up-releasing of cytochrome c (Cyto-c), contributing to apoptosis in liver cancer cells.	Quercetin	29-38	cytochrome c, somatic	Homo sapiens	134-146
28259895-8	2017	Further study suggested that quercetin nanoparticle accelerated the cleavage of caspase-9, caspase-3, and induced the up-releasing of cytochrome c (Cyto-c), contributing to apoptosis in liver cancer cells.	Quercetin	29-38	cytochrome c, somatic	Homo sapiens	148-154
28259895-9	2017	Quercetin nanoparticles also promoted telomerase reverse transcriptase (hTERT) inhibition through reducing AP-2beta expression and decreasing its binding to hTERT promoter.	Quercetin	0-9	telomerase reverse transcriptase	Homo sapiens	72-77
28259895-9	2017	Quercetin nanoparticles also promoted telomerase reverse transcriptase (hTERT) inhibition through reducing AP-2beta expression and decreasing its binding to hTERT promoter.	Quercetin	0-9	transcription factor AP-2 beta	Homo sapiens	107-115
28259895-9	2017	Quercetin nanoparticles also promoted telomerase reverse transcriptase (hTERT) inhibition through reducing AP-2beta expression and decreasing its binding to hTERT promoter.	Quercetin	0-9	telomerase reverse transcriptase	Homo sapiens	157-162
28259895-10	2017	In addition, quercetin nanoparticle had an inhibitory role in cyclooxygenase 2 (COX-2) via suppressing the NF-kappaB nuclear translocation and its binding to COX-2 promoter.	Quercetin	13-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	62-78
28259895-10	2017	In addition, quercetin nanoparticle had an inhibitory role in cyclooxygenase 2 (COX-2) via suppressing the NF-kappaB nuclear translocation and its binding to COX-2 promoter.	Quercetin	13-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	80-85
28259895-10	2017	In addition, quercetin nanoparticle had an inhibitory role in cyclooxygenase 2 (COX-2) via suppressing the NF-kappaB nuclear translocation and its binding to COX-2 promoter.	Quercetin	13-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	158-163
28259895-11	2017	Quercetin nanoparticle also inactivated Akt and ERK1/2 signaling pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	40-43
28259895-11	2017	Quercetin nanoparticle also inactivated Akt and ERK1/2 signaling pathway.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	48-54
28259895-12	2017	Taken together, our results suggested that quercetin nanoparticle had an antitumor effect by inactivating caspase/Cyto-c pathway, suppressing AP-2beta/hTERT, inhibiting NF-kappaB/COX-2 and impeding Akt/ERK1/2 signaling pathways.	Quercetin	43-52	cytochrome c, somatic	Homo sapiens	114-120
28259895-12	2017	Taken together, our results suggested that quercetin nanoparticle had an antitumor effect by inactivating caspase/Cyto-c pathway, suppressing AP-2beta/hTERT, inhibiting NF-kappaB/COX-2 and impeding Akt/ERK1/2 signaling pathways.	Quercetin	43-52	transcription factor AP-2 beta	Homo sapiens	142-150
28259895-12	2017	Taken together, our results suggested that quercetin nanoparticle had an antitumor effect by inactivating caspase/Cyto-c pathway, suppressing AP-2beta/hTERT, inhibiting NF-kappaB/COX-2 and impeding Akt/ERK1/2 signaling pathways.	Quercetin	43-52	telomerase reverse transcriptase	Homo sapiens	151-156
28259895-12	2017	Taken together, our results suggested that quercetin nanoparticle had an antitumor effect by inactivating caspase/Cyto-c pathway, suppressing AP-2beta/hTERT, inhibiting NF-kappaB/COX-2 and impeding Akt/ERK1/2 signaling pathways.	Quercetin	43-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	179-184
28259895-12	2017	Taken together, our results suggested that quercetin nanoparticle had an antitumor effect by inactivating caspase/Cyto-c pathway, suppressing AP-2beta/hTERT, inhibiting NF-kappaB/COX-2 and impeding Akt/ERK1/2 signaling pathways.	Quercetin	43-52	AKT serine/threonine kinase 1	Homo sapiens	198-201
28259895-12	2017	Taken together, our results suggested that quercetin nanoparticle had an antitumor effect by inactivating caspase/Cyto-c pathway, suppressing AP-2beta/hTERT, inhibiting NF-kappaB/COX-2 and impeding Akt/ERK1/2 signaling pathways.	Quercetin	43-52	mitogen-activated protein kinase 3	Homo sapiens	202-208
28804614-7	2017	In addition, pre-treatment with QUE and OST decreased CIS-induced apoptosis through up-regulation of Bcl-2, inhibition of caspase-3 activity, and mitochondrial membrane potential (MMP) increase.	Quercetin	32-35	BCL2, apoptosis regulator	Rattus norvegicus	101-106
28804614-7	2017	In addition, pre-treatment with QUE and OST decreased CIS-induced apoptosis through up-regulation of Bcl-2, inhibition of caspase-3 activity, and mitochondrial membrane potential (MMP) increase.	Quercetin	32-35	caspase 3	Rattus norvegicus	122-131
28107044-0	2017	Quercetin Attenuates Cell Survival, Inflammation, and Angiogenesis via Modulation of AKT Signaling in Murine T-Cell Lymphoma.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	85-88
28107044-8	2017	Results show downregulation in phosphorylation of AKT and PDK1 by quercetin, which was consistent with decreased phosphorylation of downstream survival factors such as BAD, GSK-3beta, mTOR, and IkBalpha.	Quercetin	66-75	thymoma viral proto-oncogene 1	Mus musculus	50-53
28110104-5	2017	Immunohistochemistry showed that oral administration of quercetin increased nestin-, DCX-, BrdU/DCX-, and BrdU/NeuN-positive cells in the dentate gyrus of mice.	Quercetin	56-65	doublecortin	Mus musculus	96-99
28107044-8	2017	Results show downregulation in phosphorylation of AKT and PDK1 by quercetin, which was consistent with decreased phosphorylation of downstream survival factors such as BAD, GSK-3beta, mTOR, and IkBalpha.	Quercetin	66-75	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	58-62
28110104-5	2017	Immunohistochemistry showed that oral administration of quercetin increased nestin-, DCX-, BrdU/DCX-, and BrdU/NeuN-positive cells in the dentate gyrus of mice.	Quercetin	56-65	RNA binding protein, fox-1 homolog (C. elegans) 3	Mus musculus	111-115
28110104-6	2017	However, quercetin decreased the viability of human embryonic NSCs in culture, accompanied by decreased Akt phosphorylation and increased cleavage of caspase-3 and PARP.	Quercetin	9-18	AKT serine/threonine kinase 1	Homo sapiens	104-107
28107044-8	2017	Results show downregulation in phosphorylation of AKT and PDK1 by quercetin, which was consistent with decreased phosphorylation of downstream survival factors such as BAD, GSK-3beta, mTOR, and IkBalpha.	Quercetin	66-75	glycogen synthase kinase 3 beta	Mus musculus	173-182
28110104-6	2017	However, quercetin decreased the viability of human embryonic NSCs in culture, accompanied by decreased Akt phosphorylation and increased cleavage of caspase-3 and PARP.	Quercetin	9-18	caspase 3	Homo sapiens	150-159
28107044-8	2017	Results show downregulation in phosphorylation of AKT and PDK1 by quercetin, which was consistent with decreased phosphorylation of downstream survival factors such as BAD, GSK-3beta, mTOR, and IkBalpha.	Quercetin	66-75	mechanistic target of rapamycin kinase	Mus musculus	184-188
28110104-6	2017	However, quercetin decreased the viability of human embryonic NSCs in culture, accompanied by decreased Akt phosphorylation and increased cleavage of caspase-3 and PARP.	Quercetin	9-18	poly(ADP-ribose) polymerase 1	Homo sapiens	164-168
28107044-9	2017	Further, quercetin attenuated the levels of angiogenic factor VEGF-A and inflammatory enzymes COX-2 and iNOS as well as NO levels, whereas it increased the levels of phosphatase PTEN.	Quercetin	9-18	vascular endothelial growth factor A	Mus musculus	62-68
28107044-9	2017	Further, quercetin attenuated the levels of angiogenic factor VEGF-A and inflammatory enzymes COX-2 and iNOS as well as NO levels, whereas it increased the levels of phosphatase PTEN.	Quercetin	9-18	cytochrome c oxidase II, mitochondrial	Mus musculus	94-99
28110104-12	2017	Our results demonstrate that quercetin and its metabolite Q3GA control NSC viability in a converse manner through contrary regulation of Akt, accounting for the conflicting effects of quercetin in vivo and in vitro.	Quercetin	29-38	thymoma viral proto-oncogene 1	Mus musculus	137-140
28107044-9	2017	Further, quercetin attenuated the levels of angiogenic factor VEGF-A and inflammatory enzymes COX-2 and iNOS as well as NO levels, whereas it increased the levels of phosphatase PTEN.	Quercetin	9-18	nitric oxide synthase 2, inducible	Mus musculus	104-108
28107044-9	2017	Further, quercetin attenuated the levels of angiogenic factor VEGF-A and inflammatory enzymes COX-2 and iNOS as well as NO levels, whereas it increased the levels of phosphatase PTEN.	Quercetin	9-18	phosphatase and tensin homolog	Mus musculus	178-182
28107044-10	2017	Overall results suggest that quercetin modulates AKT signaling leading to attenuation of cell survival, inflammation, and angiogenesis in lymphoma-bearing mice.	Quercetin	29-38	thymoma viral proto-oncogene 1	Mus musculus	49-52
28110104-12	2017	Our results demonstrate that quercetin and its metabolite Q3GA control NSC viability in a converse manner through contrary regulation of Akt, accounting for the conflicting effects of quercetin in vivo and in vitro.	Quercetin	184-193	thymoma viral proto-oncogene 1	Mus musculus	137-140
28144805-0	2017	Quercetin Improves Neurobehavioral Performance Through Restoration of Brain Antioxidant Status and Acetylcholinesterase Activity in Manganese-Treated Rats.	Quercetin	0-9	acetylcholinesterase	Rattus norvegicus	99-119
28144805-5	2017	Moreover, quercetin assuaged manganese-induced decrease in antioxidant enzymes activities and the increase in acetylcholinesterase activity, hydrogen peroxide generation and lipid peroxidation levels in the hypothalamus, cerebrum and cerebellum of the rats.	Quercetin	10-19	acetylcholinesterase	Rattus norvegicus	110-130
28144805-6	2017	Taken together, quercetin mechanisms of ameliorating manganese-induced neurotoxicity is associated with restoration of acetylcholinesterase activity, augmentation of redox status and inhibition of lipid peroxidation in brain of rats.	Quercetin	16-25	acetylcholinesterase	Rattus norvegicus	119-139
28341573-0	2017	Quercetin alters uterine fluid volume and aquaporin (AQP) subunits (AQP-1, 2, 5 &amp; 7) expression in the uterus in the presence of sex-steroids in rats.	Quercetin	0-9	aquaporin 1	Rattus norvegicus	68-73
28539723-10	2017	Flavonoids in the ECCF were found to contain bergenin, quercitrin, and quercetin with reported anti-inflammatory activity via suppressing tumor necrosis factor-alpha production.	Quercetin	71-80	tumor necrosis factor	Mus musculus	138-165
28189992-9	2017	In in vitro assessment of CYP3A activity model the erythromycin-N-demethylation (EMD) levels in quercetin treated group were significantly reduced (p&lt;0.05).	Quercetin	96-105	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	26-31
28341573-6	2017	Administration of quercetin in E-treated rats decreased the uterine fluid volume and uterine AQP-2 expression.	Quercetin	18-27	aquaporin 2	Rattus norvegicus	93-98
28341573-7	2017	In E+P-treated rats, administration of 100mg/kg/day quercetin increased uterine fluid volume, AQP-1 and 2 expression but decreased AQP-7 expression in uterus.	Quercetin	52-61	aquaporin 1	Rattus norvegicus	94-105
28341573-7	2017	In E+P-treated rats, administration of 100mg/kg/day quercetin increased uterine fluid volume, AQP-1 and 2 expression but decreased AQP-7 expression in uterus.	Quercetin	52-61	aquaporin 7	Rattus norvegicus	131-136
28446273-5	2017	The expression of gamma-H2AX was markedly enhanced and the phosphorylation of JNK up-regulated by quercetin in both imatinib-resistant and imatinib-sensitive cell lines.	Quercetin	98-107	mitogen-activated protein kinase 8	Homo sapiens	78-81
28507412-4	2017	RESULTS: Quercetin-treated neutrophils exhibited a remarkable suppression in MIR24-2, MIR146A, and MIR181C expression.	Quercetin	9-18	microRNA 24	Bos taurus	77-84
28507412-4	2017	RESULTS: Quercetin-treated neutrophils exhibited a remarkable suppression in MIR24-2, MIR146A, and MIR181C expression.	Quercetin	9-18	microRNA 146a	Bos taurus	86-93
28507412-4	2017	RESULTS: Quercetin-treated neutrophils exhibited a remarkable suppression in MIR24-2, MIR146A, and MIR181C expression.	Quercetin	9-18	microRNA 181c	Bos taurus	99-106
28507412-5	2017	Similarly, mRNA expression of IL1B, IL6, CXCL8, TLR4, and TNF genes noticeably declined in the quercetin group.	Quercetin	95-104	interleukin 1 beta	Bos taurus	30-34
28507412-5	2017	Similarly, mRNA expression of IL1B, IL6, CXCL8, TLR4, and TNF genes noticeably declined in the quercetin group.	Quercetin	95-104	interferon beta-2	Bos taurus	36-39
28291803-7	2017	Combination of the Hsp70-inducing inhibitors of Hsp90 with known inhibitors of the Hsp induction such as quercetin, triptolide, KNK437, NZ28 prevented up-regulation of Hsp70 in the cancer cells thereby increasing their post-radiation apoptotic/necrotic death and decreasing their post-radiation viability/clonogenicity.	Quercetin	105-114	heat shock protein family A (Hsp70) member 4	Homo sapiens	19-24
28507412-5	2017	Similarly, mRNA expression of IL1B, IL6, CXCL8, TLR4, and TNF genes noticeably declined in the quercetin group.	Quercetin	95-104	C-X-C motif chemokine ligand 8	Bos taurus	41-46
28507412-5	2017	Similarly, mRNA expression of IL1B, IL6, CXCL8, TLR4, and TNF genes noticeably declined in the quercetin group.	Quercetin	95-104	toll like receptor 4	Bos taurus	48-52
28507412-5	2017	Similarly, mRNA expression of IL1B, IL6, CXCL8, TLR4, and TNF genes noticeably declined in the quercetin group.	Quercetin	95-104	tumor necrosis factor	Bos taurus	58-61
28291803-7	2017	Combination of the Hsp70-inducing inhibitors of Hsp90 with known inhibitors of the Hsp induction such as quercetin, triptolide, KNK437, NZ28 prevented up-regulation of Hsp70 in the cancer cells thereby increasing their post-radiation apoptotic/necrotic death and decreasing their post-radiation viability/clonogenicity.	Quercetin	105-114	heat shock protein 90 alpha family class A member 1	Homo sapiens	48-53
28291803-7	2017	Combination of the Hsp70-inducing inhibitors of Hsp90 with known inhibitors of the Hsp induction such as quercetin, triptolide, KNK437, NZ28 prevented up-regulation of Hsp70 in the cancer cells thereby increasing their post-radiation apoptotic/necrotic death and decreasing their post-radiation viability/clonogenicity.	Quercetin	105-114	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	19-22
28291803-7	2017	Combination of the Hsp70-inducing inhibitors of Hsp90 with known inhibitors of the Hsp induction such as quercetin, triptolide, KNK437, NZ28 prevented up-regulation of Hsp70 in the cancer cells thereby increasing their post-radiation apoptotic/necrotic death and decreasing their post-radiation viability/clonogenicity.	Quercetin	105-114	heat shock protein family A (Hsp70) member 4	Homo sapiens	168-173
25897620-7	2017	Combined estimate of effect size for the impact of quercetin on plasma LDL-C (WMD: 1.43 mg/dL, 95% CI: -0.92-3.78, p = 0.23), HDL-C (WMD: 0.26 mg/dL, 95% CI: -0.74-1.25, p = 0.61) and triglycerides (WMD: -9.42 mg/dL, 95% CI: -27.80-8.96, p = 0.32) was not statistically significant.	Quercetin	51-60	component of oligomeric golgi complex 2	Homo sapiens	71-76
28193870-7	2017	Docking in silico of 121 pesticide contaminants of American hives into the active pocket of CYP9Q1, a broadly substrate-specific P450 with high quercetin-metabolizing activity, identified six triazole fungicides, all fungal P450 inhibitors, that dock in the catalytic site.	Quercetin	144-153	cytochrome P450 9e2	Apis mellifera	92-98
28193870-7	2017	Docking in silico of 121 pesticide contaminants of American hives into the active pocket of CYP9Q1, a broadly substrate-specific P450 with high quercetin-metabolizing activity, identified six triazole fungicides, all fungal P450 inhibitors, that dock in the catalytic site.	Quercetin	144-153	cytoplasmic protein NCK1	Apis mellifera	246-250
28264020-5	2017	In this study, we investigated the anti-cancer effect of quercetin on HepG2 tumor-bearing nude mice and its effect on cyclin D1 expression in the tumor tissue.	Quercetin	57-66	cyclin D1	Mus musculus	118-127
28264020-13	2017	Our findings thus suggest that quercetin can significantly inhibit HepG2 cell proliferation, and this effect may be achieved through the regulation of cyclin D1 expression.	Quercetin	31-40	cyclin D1	Homo sapiens	151-160
25897620-3	2017	METHODS: A systematic literature search of Medline was conducted for RCTs that investigated the efficacy of quercetin supplementation on plasma lipids comprising total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides.	Quercetin	108-117	component of oligomeric golgi complex 2	Homo sapiens	181-216
28253299-8	2017	Administration of quercetin at increasing doses increased uterine fluid secretion rate, Na+, Cl- and HCO3- concentrations, but to the levels lesser than that of E. In concordant, levels of CFTR, SLC4A4, ENaC (alpha, beta and gamma), Na+/K+-ATPase, GPalpha/beta, AC and cAMP in the uterus increased following increased in the doses of quercetin.	Quercetin	18-27	CF transmembrane conductance regulator	Rattus norvegicus	189-193
28253299-8	2017	Administration of quercetin at increasing doses increased uterine fluid secretion rate, Na+, Cl- and HCO3- concentrations, but to the levels lesser than that of E. In concordant, levels of CFTR, SLC4A4, ENaC (alpha, beta and gamma), Na+/K+-ATPase, GPalpha/beta, AC and cAMP in the uterus increased following increased in the doses of quercetin.	Quercetin	18-27	solute carrier family 4 member 4	Rattus norvegicus	195-201
28253299-12	2017	Co-administration of high dose quercetin (100 mg/kg/day) with E+P caused uterine CFTR, SLC26A6, AC, GPalpha/beta and ENaC (alpha, beta and gamma) to increase.	Quercetin	31-40	CF transmembrane conductance regulator	Rattus norvegicus	81-85
28253299-12	2017	Co-administration of high dose quercetin (100 mg/kg/day) with E+P caused uterine CFTR, SLC26A6, AC, GPalpha/beta and ENaC (alpha, beta and gamma) to increase.	Quercetin	31-40	solute carrier family 26 member 6	Rattus norvegicus	87-94
27887793-3	2017	Our results showed that quercetin triggered BCL2/BAX-mediated apoptosis, as well as necrosis and mitotic catastrophe, and inhibited the migratory potential of A549 cells.	Quercetin	24-33	BCL2 apoptosis regulator	Homo sapiens	44-48
27887793-3	2017	Our results showed that quercetin triggered BCL2/BAX-mediated apoptosis, as well as necrosis and mitotic catastrophe, and inhibited the migratory potential of A549 cells.	Quercetin	24-33	BCL2 associated X, apoptosis regulator	Homo sapiens	49-52
27887793-4	2017	The disassembling effect of quercetin on microfilaments, microtubules and vimentin filaments along with its inhibitory impact on vimentin and N-cadherin expression might account for the decreased migration of A549 cells in response to quercetin treatment.	Quercetin	28-37	vimentin	Homo sapiens	74-82
28149015-3	2017	Oral treatment of quercetin (50 mg/kg b.w) to hyperammonemic rats (1) increased the expression of urea cycle enzymes (CPS-1, OTC, ASS and ARG), neuronal and astrocytic markers (GS and PAG) (2) decreased the expression of IL6, iNOS and NF-kappaB and (3) upregulated mRNA expression of SGC, GFAP and ASS.	Quercetin	18-27	carbamoyl-phosphate synthase 1	Rattus norvegicus	118-123
27887793-4	2017	The disassembling effect of quercetin on microfilaments, microtubules and vimentin filaments along with its inhibitory impact on vimentin and N-cadherin expression might account for the decreased migration of A549 cells in response to quercetin treatment.	Quercetin	28-37	vimentin	Homo sapiens	129-137
27887793-4	2017	The disassembling effect of quercetin on microfilaments, microtubules and vimentin filaments along with its inhibitory impact on vimentin and N-cadherin expression might account for the decreased migration of A549 cells in response to quercetin treatment.	Quercetin	28-37	cadherin 2	Homo sapiens	142-152
27887793-4	2017	The disassembling effect of quercetin on microfilaments, microtubules and vimentin filaments along with its inhibitory impact on vimentin and N-cadherin expression might account for the decreased migration of A549 cells in response to quercetin treatment.	Quercetin	235-244	cadherin 2	Homo sapiens	142-152
28025042-0	2017	Quercetin ameliorates chronic unpredicted stress-mediated memory dysfunction in male Swiss albino mice by attenuating insulin resistance and elevating hippocampal GLUT4 levels independent of insulin receptor expression.	Quercetin	0-9	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	163-168
28025042-13	2017	CUS markedly down-regulated insulin signaling in CA3 region and quercetin treatment improved neuronal GLUT4 expression, which seemed to be independent of insulin and insulin receptor levels.	Quercetin	64-73	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	102-107
28149015-3	2017	Oral treatment of quercetin (50 mg/kg b.w) to hyperammonemic rats (1) increased the expression of urea cycle enzymes (CPS-1, OTC, ASS and ARG), neuronal and astrocytic markers (GS and PAG) (2) decreased the expression of IL6, iNOS and NF-kappaB and (3) upregulated mRNA expression of SGC, GFAP and ASS.	Quercetin	18-27	ornithine transcarbamylase	Rattus norvegicus	125-128
28149015-3	2017	Oral treatment of quercetin (50 mg/kg b.w) to hyperammonemic rats (1) increased the expression of urea cycle enzymes (CPS-1, OTC, ASS and ARG), neuronal and astrocytic markers (GS and PAG) (2) decreased the expression of IL6, iNOS and NF-kappaB and (3) upregulated mRNA expression of SGC, GFAP and ASS.	Quercetin	18-27	interleukin 6	Rattus norvegicus	221-224
28149015-3	2017	Oral treatment of quercetin (50 mg/kg b.w) to hyperammonemic rats (1) increased the expression of urea cycle enzymes (CPS-1, OTC, ASS and ARG), neuronal and astrocytic markers (GS and PAG) (2) decreased the expression of IL6, iNOS and NF-kappaB and (3) upregulated mRNA expression of SGC, GFAP and ASS.	Quercetin	18-27	nitric oxide synthase 2	Rattus norvegicus	226-230
28149015-3	2017	Oral treatment of quercetin (50 mg/kg b.w) to hyperammonemic rats (1) increased the expression of urea cycle enzymes (CPS-1, OTC, ASS and ARG), neuronal and astrocytic markers (GS and PAG) (2) decreased the expression of IL6, iNOS and NF-kappaB and (3) upregulated mRNA expression of SGC, GFAP and ASS.	Quercetin	18-27	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	284-287
28149015-3	2017	Oral treatment of quercetin (50 mg/kg b.w) to hyperammonemic rats (1) increased the expression of urea cycle enzymes (CPS-1, OTC, ASS and ARG), neuronal and astrocytic markers (GS and PAG) (2) decreased the expression of IL6, iNOS and NF-kappaB and (3) upregulated mRNA expression of SGC, GFAP and ASS.	Quercetin	18-27	glial fibrillary acidic protein	Rattus norvegicus	289-293
27794191-6	2017	This increased intracellular iron complexed to quercetin does not associate with the labile iron pool and cells behave as though they are iron deficient (increased transferrin receptor-1 and iron regulatory protein-2 expression and low ferritin expression).	Quercetin	47-56	iron responsive element binding protein 2	Homo sapiens	191-216
28092744-0	2017	Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	96-99
28092744-0	2017	Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	100-104
28092744-0	2017	Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	109-114
28092744-2	2017	Quercetin interacts with multiple cancer-related pathways such as PI3K/AKT, Wnt/beta-catenin and STAT3.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	71-74
28092744-2	2017	Quercetin interacts with multiple cancer-related pathways such as PI3K/AKT, Wnt/beta-catenin and STAT3.	Quercetin	0-9	catenin beta 1	Homo sapiens	80-92
28092744-2	2017	Quercetin interacts with multiple cancer-related pathways such as PI3K/AKT, Wnt/beta-catenin and STAT3.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	97-102
28092744-4	2017	In this study, we found that quercetin inhibited PI3K/AKT/mTOR and STAT3 pathways in PEL cells, and as a consequence, it down-regulated the expression of the prosurvival cellular proteins such as c-FLIP, cyclin D1 and cMyc.	Quercetin	29-38	AKT serine/threonine kinase 1	Homo sapiens	54-57
28092744-4	2017	In this study, we found that quercetin inhibited PI3K/AKT/mTOR and STAT3 pathways in PEL cells, and as a consequence, it down-regulated the expression of the prosurvival cellular proteins such as c-FLIP, cyclin D1 and cMyc.	Quercetin	29-38	mechanistic target of rapamycin kinase	Homo sapiens	58-62
28092744-4	2017	In this study, we found that quercetin inhibited PI3K/AKT/mTOR and STAT3 pathways in PEL cells, and as a consequence, it down-regulated the expression of the prosurvival cellular proteins such as c-FLIP, cyclin D1 and cMyc.	Quercetin	29-38	signal transducer and activator of transcription 3	Homo sapiens	67-72
28092744-4	2017	In this study, we found that quercetin inhibited PI3K/AKT/mTOR and STAT3 pathways in PEL cells, and as a consequence, it down-regulated the expression of the prosurvival cellular proteins such as c-FLIP, cyclin D1 and cMyc.	Quercetin	29-38	PYD and CARD domain containing	Homo sapiens	193-197
28092744-4	2017	In this study, we found that quercetin inhibited PI3K/AKT/mTOR and STAT3 pathways in PEL cells, and as a consequence, it down-regulated the expression of the prosurvival cellular proteins such as c-FLIP, cyclin D1 and cMyc.	Quercetin	29-38	cyclin D1	Homo sapiens	204-213
28092744-4	2017	In this study, we found that quercetin inhibited PI3K/AKT/mTOR and STAT3 pathways in PEL cells, and as a consequence, it down-regulated the expression of the prosurvival cellular proteins such as c-FLIP, cyclin D1 and cMyc.	Quercetin	29-38	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	218-222
28280414-0	2017	Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity.	Quercetin	0-9	forkhead box O3	Homo sapiens	111-117
28280414-5	2017	Moreover, quercetin increased FasL mRNA expression and p51, p21 and GADD45 signaling activities.	Quercetin	10-19	Fas ligand	Homo sapiens	30-34
28280414-5	2017	Moreover, quercetin increased FasL mRNA expression and p51, p21 and GADD45 signaling activities.	Quercetin	10-19	tumor protein p63	Homo sapiens	55-58
28280414-5	2017	Moreover, quercetin increased FasL mRNA expression and p51, p21 and GADD45 signaling activities.	Quercetin	10-19	H3 histone pseudogene 16	Homo sapiens	60-63
28280414-5	2017	Moreover, quercetin increased FasL mRNA expression and p51, p21 and GADD45 signaling activities.	Quercetin	10-19	growth arrest and DNA damage inducible alpha	Homo sapiens	68-74
28280414-6	2017	We also observed that quercetin induced protein level, transcriptional activity and nuclear translocation of Foxo3a.	Quercetin	22-31	forkhead box O3	Homo sapiens	109-115
28280414-7	2017	Knockdown of Foxo3a caused significant reduction in the effect of quercetin on cell apoptosis and cell cycle arrest.	Quercetin	66-75	forkhead box O3	Homo sapiens	13-19
28280414-8	2017	In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity.	Quercetin	62-71	mitogen-activated protein kinase 8	Homo sapiens	26-29
28280414-8	2017	In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity.	Quercetin	62-71	forkhead box O3	Homo sapiens	83-89
28280414-8	2017	In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity.	Quercetin	62-71	mitogen-activated protein kinase 8	Homo sapiens	111-114
28280414-8	2017	In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity.	Quercetin	62-71	forkhead box O3	Homo sapiens	165-171
28280414-9	2017	Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin.	Quercetin	121-130	forkhead box O3	Homo sapiens	13-19
28280414-9	2017	Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin.	Quercetin	121-130	mitogen-activated protein kinase 8	Homo sapiens	38-41
28280414-9	2017	Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin.	Quercetin	121-130	tumor protein p53	Homo sapiens	87-90
28280414-9	2017	Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin.	Quercetin	121-130	H3 histone pseudogene 16	Homo sapiens	92-95
28280414-9	2017	Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin.	Quercetin	121-130	growth arrest and DNA damage inducible alpha	Homo sapiens	100-106
28280414-10	2017	Taken together, our study suggests that quercetin induces apoptosis and cell cycle arrest via modification of Foxo3a signaling in triple-negative breast cancer cells.	Quercetin	40-49	forkhead box O3	Homo sapiens	110-116
28121480-2	2017	Quercetin, a flavonoid with antioxidant potential, inhibits butyrylcholinesterase (BuChE), which is positively associated with hyperglycemia.	Quercetin	0-9	butyrylcholinesterase	Rattus norvegicus	60-81
28121480-2	2017	Quercetin, a flavonoid with antioxidant potential, inhibits butyrylcholinesterase (BuChE), which is positively associated with hyperglycemia.	Quercetin	0-9	butyrylcholinesterase	Rattus norvegicus	83-88
28121480-11	2017	The BuChE activity decreased in the intestine at all tested doses of quercetin coadministered with tamoxifen (P &lt; .01); however, in adipose tissue, there was a biphasic activity with a decrease (P &lt; .05) and increase (P &lt; .05) in activity at doses of 7.5 and 22.5 mg.kg-1 b.w.	Quercetin	69-78	butyrylcholinesterase	Rattus norvegicus	4-9
28011344-9	2017	With the goal of a future dermal application, quercetin lipid nanocapsules were applied to THP-1 monocytes and proved the cellular safety of the formulation up to 2mug/ml of quercetin.	Quercetin	46-55	GLI family zinc finger 2	Homo sapiens	91-96
28454351-0	2017	The role of quercetin and vitamin C in Nrf2-dependent oxidative stress production in breast cancer cells.	Quercetin	12-21	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
28454351-3	2017	The present study investigated the role of vitamin C (VC) and quercetin (Q) in the induction of Nrf2-mediated oxidative stress in cancer cells.	Quercetin	62-71	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
28454351-10	2017	Following treatment with VC and Q, the nuclear/cytosolic Nrf2 ratio was reduced by 1.7-fold in MDA-MB 231 cells, 2-fold in MDA-MB 468 cells, 1.4-fold in MCF-7 cells and 1.2 fold in A549 cells.	Quercetin	32-33	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
28065794-3	2017	Hence, this study was envisaged to evaluate the dose dependent inhibition of indoleamine 2,3-dioxygenase (IDO) enzyme employing quercetin (screened employing in vitro method) with levetiracetam for combined management of epilepsy and comorbid depression.	Quercetin	128-137	indoleamine 2,3-dioxygenase 1	Mus musculus	77-104
28065794-3	2017	Hence, this study was envisaged to evaluate the dose dependent inhibition of indoleamine 2,3-dioxygenase (IDO) enzyme employing quercetin (screened employing in vitro method) with levetiracetam for combined management of epilepsy and comorbid depression.	Quercetin	128-137	indoleamine 2,3-dioxygenase 1	Mus musculus	106-109
28274305-0	2017	[Protective effect of quercetin against immunological liver injury through activating Nrf2/ARE signaling pathway].	Quercetin	22-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
28274305-10	2017	Results Compared with the model group, the serum activities of ALT and AST as well as MDA content remarkably decreased by the administration of quercetin (80 mg/kg), while GSH, SOD contents were elevated in liver tissues; pathologic changes of the liver was ameliorated evidently by quercetin; Nrf2 protein expression in the nucleus as well as mRNA expressions of HO-1, NQO1, GCLC increased.	Quercetin	144-153	glutamic pyruvic transaminase, soluble	Mus musculus	63-66
28274305-10	2017	Results Compared with the model group, the serum activities of ALT and AST as well as MDA content remarkably decreased by the administration of quercetin (80 mg/kg), while GSH, SOD contents were elevated in liver tissues; pathologic changes of the liver was ameliorated evidently by quercetin; Nrf2 protein expression in the nucleus as well as mRNA expressions of HO-1, NQO1, GCLC increased.	Quercetin	144-153	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	71-74
28274305-10	2017	Results Compared with the model group, the serum activities of ALT and AST as well as MDA content remarkably decreased by the administration of quercetin (80 mg/kg), while GSH, SOD contents were elevated in liver tissues; pathologic changes of the liver was ameliorated evidently by quercetin; Nrf2 protein expression in the nucleus as well as mRNA expressions of HO-1, NQO1, GCLC increased.	Quercetin	144-153	nuclear factor, erythroid derived 2, like 2	Mus musculus	294-298
28274305-10	2017	Results Compared with the model group, the serum activities of ALT and AST as well as MDA content remarkably decreased by the administration of quercetin (80 mg/kg), while GSH, SOD contents were elevated in liver tissues; pathologic changes of the liver was ameliorated evidently by quercetin; Nrf2 protein expression in the nucleus as well as mRNA expressions of HO-1, NQO1, GCLC increased.	Quercetin	144-153	heme oxygenase 1	Mus musculus	364-368
28274305-10	2017	Results Compared with the model group, the serum activities of ALT and AST as well as MDA content remarkably decreased by the administration of quercetin (80 mg/kg), while GSH, SOD contents were elevated in liver tissues; pathologic changes of the liver was ameliorated evidently by quercetin; Nrf2 protein expression in the nucleus as well as mRNA expressions of HO-1, NQO1, GCLC increased.	Quercetin	144-153	NAD(P)H dehydrogenase, quinone 1	Mus musculus	370-374
28274305-10	2017	Results Compared with the model group, the serum activities of ALT and AST as well as MDA content remarkably decreased by the administration of quercetin (80 mg/kg), while GSH, SOD contents were elevated in liver tissues; pathologic changes of the liver was ameliorated evidently by quercetin; Nrf2 protein expression in the nucleus as well as mRNA expressions of HO-1, NQO1, GCLC increased.	Quercetin	144-153	glutamate-cysteine ligase, catalytic subunit	Mus musculus	376-380
28274305-12	2017	Conclusion High-dose quercetin can inhibit immunological liver injury induced by triptolide, and the mechanism may be associated with the activation of Nrf2/ARE signaling pathway.	Quercetin	21-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	152-156
28011344-10	2017	Finally, formulated quercetin was as efficient as the crude form in the protection of THP-1 cells from oxidative stress by exogenous hydrogen peroxide.	Quercetin	20-29	GLI family zinc finger 2	Homo sapiens	86-91
28224126-9	2017	Interestingly, quercetin prevented the glial and neuronal loss with a higher density for the HuC/D-immunoreactive neurons (23.06%) and for the S100-immunoreactive glial cells (14.55%) in DQ group compared to D group.	Quercetin	15-24	ELAV like RNA binding protein 3	Rattus norvegicus	93-96
28148962-0	2017	Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis.	Quercetin	0-9	steroid sulfatase	Mus musculus	63-66
28043777-1	2017	Previously, we have reported remarkable effect of a quercetin-glutamic acid conjugate to reverse multidrug resistance (MDR) of cancer cells to a broad spectrum of anticancer agents through inhibition of P-glycoprotein (Pgp)-mediated drug efflux.	Quercetin	52-61	ATP binding cassette subfamily B member 1	Homo sapiens	203-217
27812823-1	2017	OBJECTIVES: To investigate the lipase-catalyzed acylation of quercetin with oleic acid using Candida antarctica lipase B.	Quercetin	61-70	PAN0_003d1715	Moesziomyces antarcticus	31-37
27812823-1	2017	OBJECTIVES: To investigate the lipase-catalyzed acylation of quercetin with oleic acid using Candida antarctica lipase B.	Quercetin	61-70	PAN0_003d1715	Moesziomyces antarcticus	112-118
27283837-0	2017	Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model.	Quercetin	0-9	nuclear factor kappa B subunit 1	Rattus norvegicus	112-137
27283837-0	2017	Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model.	Quercetin	0-9	nuclear factor kappa B subunit 1	Rattus norvegicus	139-144
28043777-1	2017	Previously, we have reported remarkable effect of a quercetin-glutamic acid conjugate to reverse multidrug resistance (MDR) of cancer cells to a broad spectrum of anticancer agents through inhibition of P-glycoprotein (Pgp)-mediated drug efflux.	Quercetin	52-61	ATP binding cassette subfamily B member 1	Homo sapiens	219-222
28043777-5	2017	Pgp inhibition assay, Pgp ATPase assay, and MDR-reversal activity assay were performed, and the non-hydrolysable quercetin conjugates showed significantly higher activities compared with those of quercetin.	Quercetin	113-122	ATP binding cassette subfamily B member 1	Homo sapiens	0-3
28043777-5	2017	Pgp inhibition assay, Pgp ATPase assay, and MDR-reversal activity assay were performed, and the non-hydrolysable quercetin conjugates showed significantly higher activities compared with those of quercetin.	Quercetin	113-122	ATP binding cassette subfamily B member 1	Homo sapiens	22-25
28040552-7	2017	Furthermore, quercetin mediated suppression of inflammatory indices and caspase-3 activity was accompanied by preservation of histo-architectures of the brain, testes and epididymis in manganese-treated rats.	Quercetin	13-22	caspase 3	Rattus norvegicus	72-81
27979659-0	2017	Quercetin induces autophagy via FOXO1-dependent pathways and autophagy suppression enhances quercetin-induced apoptosis in PASMCs in hypoxia.	Quercetin	0-9	forkhead box O1	Homo sapiens	32-37
27826992-5	2017	Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens.	Quercetin	100-109	catechol-O-methyltransferase	Homo sapiens	193-197
27826992-5	2017	Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens.	Quercetin	100-109	catechol-O-methyltransferase	Homo sapiens	307-311
28103717-8	2017	Both B. trimera and quercetin modulated reactive oxygen species production through the inhibition of PKC protein expression and enzymatic activity, also with inhibition of p47 phox phosphorylation.	Quercetin	20-29	proline rich transmembrane protein 2	Homo sapiens	101-104
28103717-8	2017	Both B. trimera and quercetin modulated reactive oxygen species production through the inhibition of PKC protein expression and enzymatic activity, also with inhibition of p47 phox phosphorylation.	Quercetin	20-29	pleckstrin	Homo sapiens	172-175
28103717-5	2017	The PKC expression by Western blot and enzyme activity was performed to evaluate the influence of B. trimera and quercetin on PKC signaling pathway.	Quercetin	113-122	proline rich transmembrane protein 2	Homo sapiens	126-129
27979659-4	2017	In addition, we found that quercetin increases FOXO1 (a major mediator in autophagy regulation) expression and transcriptional activity.	Quercetin	27-36	forkhead box O1	Homo sapiens	47-52
27979659-5	2017	Moreover, FOXO1 knockdown by siRNAs inhibited the phosphorylation of mTOR and 4E-BPI, which is downstream of P70-S6K, and markedly blocked quercetin-induced autophagy.	Quercetin	139-148	forkhead box O1	Homo sapiens	10-15
27979659-5	2017	Moreover, FOXO1 knockdown by siRNAs inhibited the phosphorylation of mTOR and 4E-BPI, which is downstream of P70-S6K, and markedly blocked quercetin-induced autophagy.	Quercetin	139-148	mechanistic target of rapamycin kinase	Homo sapiens	69-73
27979659-9	2017	Taken together, quercetin could enhance hypoxia-induced autophagy through the FOXO1-SENS3-mTOR pathway in PASMCs.	Quercetin	16-25	forkhead box O1	Homo sapiens	78-83
27824398-0	2017	Effects of Quercetin on Adiponectin-Mediated Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Double-Blind Clinical Trial.	Quercetin	11-20	adiponectin, C1Q and collagen domain containing	Homo sapiens	24-35
27979659-9	2017	Taken together, quercetin could enhance hypoxia-induced autophagy through the FOXO1-SENS3-mTOR pathway in PASMCs.	Quercetin	16-25	mechanistic target of rapamycin kinase	Homo sapiens	90-94
27824398-3	2017	Quercetin reduces serum glucose, insulin, triglycerides, and cholesterol levels and increases the expression and secretion of adiponectin.	Quercetin	0-9	insulin	Homo sapiens	33-40
28119263-8	2017	Furthermore, the mRNA and protein expression of Rac1, Rac1-GTP and NOX1 were significantly increased in BDL rats compared with those in the sham group (P&lt;0.05); quercetin treatment reversed these variables back toward normal (P&lt;0.05).	Quercetin	164-173	Rac family small GTPase 1	Rattus norvegicus	48-52
27824398-3	2017	Quercetin reduces serum glucose, insulin, triglycerides, and cholesterol levels and increases the expression and secretion of adiponectin.	Quercetin	0-9	adiponectin, C1Q and collagen domain containing	Homo sapiens	126-137
27824398-4	2017	The aim of this study was to determine the effect of quercetin on the adiponectin-mediated insulin sensitivity in PCOS patients.	Quercetin	53-62	adiponectin, C1Q and collagen domain containing	Homo sapiens	70-81
27824398-4	2017	The aim of this study was to determine the effect of quercetin on the adiponectin-mediated insulin sensitivity in PCOS patients.	Quercetin	53-62	insulin	Homo sapiens	91-98
27824398-10	2017	Oral quercetin supplementation was effective in improving the adiponectin-mediated insulin resistance and hormonal profile of women with PCOS.	Quercetin	5-14	adiponectin, C1Q and collagen domain containing	Homo sapiens	62-73
27824398-10	2017	Oral quercetin supplementation was effective in improving the adiponectin-mediated insulin resistance and hormonal profile of women with PCOS.	Quercetin	5-14	insulin	Homo sapiens	83-90
28119263-8	2017	Furthermore, the mRNA and protein expression of Rac1, Rac1-GTP and NOX1 were significantly increased in BDL rats compared with those in the sham group (P&lt;0.05); quercetin treatment reversed these variables back toward normal (P&lt;0.05).	Quercetin	164-173	Rac family small GTPase 1	Rattus norvegicus	54-58
28119263-0	2017	Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats.	Quercetin	0-9	Rac family small GTPase 1	Rattus norvegicus	81-85
28119263-8	2017	Furthermore, the mRNA and protein expression of Rac1, Rac1-GTP and NOX1 were significantly increased in BDL rats compared with those in the sham group (P&lt;0.05); quercetin treatment reversed these variables back toward normal (P&lt;0.05).	Quercetin	164-173	NADPH oxidase 1	Rattus norvegicus	67-71
28119263-0	2017	Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats.	Quercetin	0-9	NADPH oxidase 1	Rattus norvegicus	90-104
28119263-9	2017	Another interesting finding was that the antioxidant markers e.g. superoxide dismutase and catalase were elevated in quercetin-treated BDL rats compared to BDL rats (P&lt;0.05).	Quercetin	117-126	catalase	Rattus norvegicus	91-99
28119263-10	2017	CONCLUSION: Quercetin demonstrated hepatoprotective activity against BDL-induced liver injury through increasing antioxidant capacity of the liver tissue, while preventing the production of Rac1, Rac1-GTP and NOX1 proteins.	Quercetin	12-21	Rac family small GTPase 1	Rattus norvegicus	190-194
28119263-10	2017	CONCLUSION: Quercetin demonstrated hepatoprotective activity against BDL-induced liver injury through increasing antioxidant capacity of the liver tissue, while preventing the production of Rac1, Rac1-GTP and NOX1 proteins.	Quercetin	12-21	Rac family small GTPase 1	Rattus norvegicus	196-200
28119263-10	2017	CONCLUSION: Quercetin demonstrated hepatoprotective activity against BDL-induced liver injury through increasing antioxidant capacity of the liver tissue, while preventing the production of Rac1, Rac1-GTP and NOX1 proteins.	Quercetin	12-21	NADPH oxidase 1	Rattus norvegicus	209-213
28000870-5	2017	Quercetin was demonstrated to protect against glucosamine-induced apoptosis, improved cell viability, and inhibited expression of pro-inflammatory factors and endothelin-1.	Quercetin	0-9	endothelin 1	Homo sapiens	159-171
28400803-6	2017	In addition, pretreatment with QE significantly increased the expression levels of endogenous antioxidant enzymes Cu/Zn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in the hippocampal CA1 pyramidal neurons of animals with ischemic injury.	Quercetin	31-33	superoxide dismutase 1	Homo sapiens	114-140
28400803-6	2017	In addition, pretreatment with QE significantly increased the expression levels of endogenous antioxidant enzymes Cu/Zn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in the hippocampal CA1 pyramidal neurons of animals with ischemic injury.	Quercetin	31-33	catalase	Homo sapiens	167-175
28400803-0	2017	Pretreated quercetin protects gerbil hippocampal CA1 pyramidal neurons from transient cerebral ischemic injury by increasing the expression of antioxidant enzymes.	Quercetin	11-20	carbonic anhydrase 1	Homo sapiens	49-52
28400803-6	2017	In addition, pretreatment with QE significantly increased the expression levels of endogenous antioxidant enzymes Cu/Zn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in the hippocampal CA1 pyramidal neurons of animals with ischemic injury.	Quercetin	31-33	carbonic anhydrase 1	Homo sapiens	222-225
28400803-5	2017	Pretreatment with QE protected hippocampal CA1 pyramidal neurons from ischemic injury, which was confirmed by neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B histofluorescence staining.	Quercetin	18-20	carbonic anhydrase 1	Homo sapiens	43-46
32263677-5	2017	In vitro studies showed that quercetin significantly promoted cell proliferation, ALP activity and the expression of osteogenic and angiogenic factors of OVX rBMSCs as well as inhibited the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) in a dose-dependent manner, with a concentration of 1 muM yielding the greatest effect.	Quercetin	29-38	PDZ and LIM domain 3	Rattus norvegicus	82-85
28063518-7	2017	Finally, the individual administration of berberine, quercetin, ferulic acid, and tyrosol resulted in a statistically significant increase in AMPK activation and mTOR inhibition, whereas their associated administration did not reveal a synergistic effect.	Quercetin	53-62	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	142-146
28063518-7	2017	Finally, the individual administration of berberine, quercetin, ferulic acid, and tyrosol resulted in a statistically significant increase in AMPK activation and mTOR inhibition, whereas their associated administration did not reveal a synergistic effect.	Quercetin	53-62	mechanistic target of rapamycin kinase	Homo sapiens	162-166
28146071-4	2017	In this review, we introduce novel, unique mechanisms of quercetin"s anti-hypertensive action via activation of NKCC1 in detail.	Quercetin	57-66	solute carrier family 12 member 2	Homo sapiens	112-117
28137273-0	2017	Quercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancer.	Quercetin	0-9	microRNA 200b	Homo sapiens	18-26
32263677-5	2017	In vitro studies showed that quercetin significantly promoted cell proliferation, ALP activity and the expression of osteogenic and angiogenic factors of OVX rBMSCs as well as inhibited the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) in a dose-dependent manner, with a concentration of 1 muM yielding the greatest effect.	Quercetin	29-38	TNF superfamily member 11	Rattus norvegicus	256-261
32263677-6	2017	Moreover, the activation of the extracellular signal-regulated protein kinase (ERK), p38 and AKT signaling pathways was observed in quercetin-treated OVX rBMSCs, and the crosstalk among these signaling pathways was evident.	Quercetin	132-141	Eph receptor B1	Rattus norvegicus	32-77
32263677-6	2017	Moreover, the activation of the extracellular signal-regulated protein kinase (ERK), p38 and AKT signaling pathways was observed in quercetin-treated OVX rBMSCs, and the crosstalk among these signaling pathways was evident.	Quercetin	132-141	Eph receptor B1	Rattus norvegicus	79-82
32263677-6	2017	Moreover, the activation of the extracellular signal-regulated protein kinase (ERK), p38 and AKT signaling pathways was observed in quercetin-treated OVX rBMSCs, and the crosstalk among these signaling pathways was evident.	Quercetin	132-141	mitogen activated protein kinase 14	Rattus norvegicus	85-88
32263677-6	2017	Moreover, the activation of the extracellular signal-regulated protein kinase (ERK), p38 and AKT signaling pathways was observed in quercetin-treated OVX rBMSCs, and the crosstalk among these signaling pathways was evident.	Quercetin	132-141	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
32263677-5	2017	In vitro studies showed that quercetin significantly promoted cell proliferation, ALP activity and the expression of osteogenic and angiogenic factors of OVX rBMSCs as well as inhibited the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) in a dose-dependent manner, with a concentration of 1 muM yielding the greatest effect.	Quercetin	29-38	TNF superfamily member 11	Rattus norvegicus	204-254
28097231-4	2017	RESULTS: Following oral administration of 1,000 mg isoquercetin to healthy adults, the measured peak plasma quercetin concentration (9.2 muM) exceeded its IC50 for inhibition of PDI by isoquercetin in vitro (2.5 +- 0.4 muM).	Quercetin	54-63	prolyl 4-hydroxylase subunit beta	Homo sapiens	178-181
27979702-5	2017	Quercetin and baicalein reduced the increased metalloproteinase-9 (MMP-9) expression, liver myeloperoxidase (MPO) activity, toll-like receptor (TLR)-2,3,6,9 expression and nuclear factor kappaB (NFkappaB) transcriptional activation induced by MCT.	Quercetin	0-9	matrix metallopeptidase 9	Rattus norvegicus	67-72
27979702-5	2017	Quercetin and baicalein reduced the increased metalloproteinase-9 (MMP-9) expression, liver myeloperoxidase (MPO) activity, toll-like receptor (TLR)-2,3,6,9 expression and nuclear factor kappaB (NFkappaB) transcriptional activation induced by MCT.	Quercetin	0-9	myeloperoxidase	Rattus norvegicus	92-107
27979702-5	2017	Quercetin and baicalein reduced the increased metalloproteinase-9 (MMP-9) expression, liver myeloperoxidase (MPO) activity, toll-like receptor (TLR)-2,3,6,9 expression and nuclear factor kappaB (NFkappaB) transcriptional activation induced by MCT.	Quercetin	0-9	myeloperoxidase	Rattus norvegicus	109-112
27979702-6	2017	Quercetin and baicalein reduced MCT-induced nuclear translocation of early growth response1 (Egr1) and increased expression of Serpine1 and tissue factor (TF).	Quercetin	0-9	early growth response 1	Rattus norvegicus	93-97
27979702-6	2017	Quercetin and baicalein reduced MCT-induced nuclear translocation of early growth response1 (Egr1) and increased expression of Serpine1 and tissue factor (TF).	Quercetin	0-9	serpin family E member 1	Rattus norvegicus	127-135
27979702-6	2017	Quercetin and baicalein reduced MCT-induced nuclear translocation of early growth response1 (Egr1) and increased expression of Serpine1 and tissue factor (TF).	Quercetin	0-9	coagulation factor III, tissue factor	Rattus norvegicus	140-153
27979702-6	2017	Quercetin and baicalein reduced MCT-induced nuclear translocation of early growth response1 (Egr1) and increased expression of Serpine1 and tissue factor (TF).	Quercetin	0-9	coagulation factor III, tissue factor	Rattus norvegicus	155-157
27979702-7	2017	Quercetin and baicalein reduced MCT-induced increased liver malondialdehyde (MDA) amount and enhanced the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2).	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	131-174
27979702-7	2017	Quercetin and baicalein reduced MCT-induced increased liver malondialdehyde (MDA) amount and enhanced the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2).	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	176-180
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	citrate synthase	Mus musculus	90-106
27836895-0	2017	Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice.	Quercetin	9-18	dystrophin, muscular dystrophy	Mus musculus	54-57
28115850-0	2017	Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kappaB signaling and Nrf2 pathway in high fat diet fed mice.	Quercetin	5-14	toll-like receptor 4	Mus musculus	95-99
28115850-0	2017	Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kappaB signaling and Nrf2 pathway in high fat diet fed mice.	Quercetin	5-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	100-109
28115850-0	2017	Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kappaB signaling and Nrf2 pathway in high fat diet fed mice.	Quercetin	5-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
27836895-0	2017	Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice.	Quercetin	9-18	utrophin	Mus musculus	58-62
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	superoxide dismutase 2, mitochondrial	Mus musculus	108-112
27836895-1	2017	Duchenne Muscular Dystrophy (DMD) is associated with progressive cardiac pathology; however, the SIRT1/PGC1-alpha activator quercetin may cardioprotect dystrophic hearts.	Quercetin	124-133	sirtuin 1	Mus musculus	97-102
27836895-1	2017	Duchenne Muscular Dystrophy (DMD) is associated with progressive cardiac pathology; however, the SIRT1/PGC1-alpha activator quercetin may cardioprotect dystrophic hearts.	Quercetin	124-133	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	103-113
27836895-2	2017	We tested the extent to which long-term 0.2% dietary quercetin enrichment attenuates dystrophic cardiopathology in Mdx/Utrn+/- mice.	Quercetin	53-62	dystrophin, muscular dystrophy	Mus musculus	115-118
27836895-11	2017	Lower abundance of fibronectin, cardiac damage (Hematoxylin Eosin-Y), and MMP9 were observed in quercetin-fed vs. control Mdx/Utrn+/- mice.	Quercetin	96-105	fibronectin 1	Mus musculus	19-30
27836895-11	2017	Lower abundance of fibronectin, cardiac damage (Hematoxylin Eosin-Y), and MMP9 were observed in quercetin-fed vs. control Mdx/Utrn+/- mice.	Quercetin	96-105	matrix metallopeptidase 9	Mus musculus	74-78
27836895-11	2017	Lower abundance of fibronectin, cardiac damage (Hematoxylin Eosin-Y), and MMP9 were observed in quercetin-fed vs. control Mdx/Utrn+/- mice.	Quercetin	96-105	dystrophin, muscular dystrophy	Mus musculus	122-125
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	peroxiredoxin 6 pseudogene 2	Mus musculus	118-121
27836895-11	2017	Lower abundance of fibronectin, cardiac damage (Hematoxylin Eosin-Y), and MMP9 were observed in quercetin-fed vs. control Mdx/Utrn+/- mice.	Quercetin	96-105	utrophin	Mus musculus	126-130
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	45-55
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	utrophin	Mus musculus	152-156
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	224-232
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	transforming growth factor, beta 1	Mus musculus	234-243
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	adhesion G protein-coupled receptor E1	Mus musculus	249-254
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	dystrophin, muscular dystrophy	Mus musculus	269-272
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	utrophin	Mus musculus	273-277
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	293-301
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	303-323
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	Fc receptor, IgG, high affinity I	Mus musculus	325-329
27836895-12	2017	Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups.	Quercetin	0-9	cytochrome c oxidase II, mitochondrial	Mus musculus	335-339
27836895-13	2017	Dietary quercetin enrichment improves cardiac function in aged Mdx/Utrn+/- mice and increases mitochondrial protein content and dystrophin glycoprotein complex formation.	Quercetin	8-17	dystrophin, muscular dystrophy	Mus musculus	63-66
27836895-13	2017	Dietary quercetin enrichment improves cardiac function in aged Mdx/Utrn+/- mice and increases mitochondrial protein content and dystrophin glycoprotein complex formation.	Quercetin	8-17	utrophin	Mus musculus	67-71
27836895-16	2017	Secondary findings suggest that quercetin-dependent outcomes are in part due to PGC-1alpha pathway activation.	Quercetin	32-41	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	80-90
27919735-0	2017	Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation and apoptosis via ROS-regulated PI3K/AKT signaling pathway.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	132-135
27919735-4	2017	50 and 100mg/kg quercetin were used in our study, showing significant inhibitory role in high fructose-induced atherosclerosis via reducing reactive oxygen species (ROS) levels, Caspase-3 activation, inflammatory cytokines releasing, the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL)-positive cells and collagen contents as well as modulating apoptosis- and inflammation-related proteins expression.	Quercetin	16-25	caspase 3	Mus musculus	178-187
27919735-5	2017	We also explored the protective effects of quercetin on atherosclerosis by phosphatidylinositide 3-kinases (PI3K)/Protein kinase B (AKT)-associated Bcl-2/Caspase-3 and nuclear factor kappa B (NF-kappaB) signal pathways activation, promoting AKT and Bcl-2 expression and reducing Caspase-3 and NF-kappaB activation.	Quercetin	43-52	B cell leukemia/lymphoma 2	Mus musculus	148-153
27919735-7	2017	Also, in vitro experiments, quercetin displayed inhibitory role in LPS-induced ROS production, inflammatory response and apoptosis, which were linked with PI3K/AKT-regulated Caspase-3 and NF-kappaB activation.	Quercetin	28-37	thymoma viral proto-oncogene 1	Mus musculus	160-163
27919735-7	2017	Also, in vitro experiments, quercetin displayed inhibitory role in LPS-induced ROS production, inflammatory response and apoptosis, which were linked with PI3K/AKT-regulated Caspase-3 and NF-kappaB activation.	Quercetin	28-37	caspase 3	Mus musculus	174-183
27919735-7	2017	Also, in vitro experiments, quercetin displayed inhibitory role in LPS-induced ROS production, inflammatory response and apoptosis, which were linked with PI3K/AKT-regulated Caspase-3 and NF-kappaB activation.	Quercetin	28-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	188-197
27919735-5	2017	We also explored the protective effects of quercetin on atherosclerosis by phosphatidylinositide 3-kinases (PI3K)/Protein kinase B (AKT)-associated Bcl-2/Caspase-3 and nuclear factor kappa B (NF-kappaB) signal pathways activation, promoting AKT and Bcl-2 expression and reducing Caspase-3 and NF-kappaB activation.	Quercetin	43-52	thymoma viral proto-oncogene 1	Mus musculus	132-135
27919735-8	2017	In conclusion, our results showed that quercetin inhibited atherosclerotic plaque development in high fructose feeding mice via PI3K/AKT activation regulated by ROS.	Quercetin	39-48	thymoma viral proto-oncogene 1	Mus musculus	133-136
28381806-3	2017	In this study, we found several naturally occurring compounds (e.g., hinokitiol, escletin, and quercetin) elevate S100A3 citrullination in a human colorectal adenocarcinoma cell line (SW480).	Quercetin	95-104	S100 calcium binding protein A3	Homo sapiens	114-120
27771282-5	2017	Western blotting and qPCR identified two inducers of BCRP (quercetin and naringin) and two down-regulators (17-beta-estradiol and curcumin) with associated changes in BCRP efflux transport function further confirmed in both cell lines.	Quercetin	59-68	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	53-57
28867739-3	2017	Various flavonoids in vegetables, such as kaempferol and quercetin, possess inhibitory effects, and some vegetable and fruit juices have also been found to inhibit CYP3A4 activity.	Quercetin	57-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	164-170
28691026-8	2017	Western blot analysis showed that iNOS/p38MAPK pathway was normalized by the quercetin supplementation.	Quercetin	77-86	nitric oxide synthase 2	Rattus norvegicus	34-38
28691026-9	2017	CONCLUSIONS: Quercetin exerted a protective effect on vascular calcification in adenine-induced chronic renal failure rats, possibly through the modulation of oxidative stress and iNOs/p38MAPK pathway.	Quercetin	13-22	nitric oxide synthase 2	Rattus norvegicus	180-184
28567424-1	2017	The aim of the present study was to evaluate in vitro effects of dietary phytochemicals naringenin, quercetin, and sesamin on the activities of ethoxy- (EROD; CYP1A) and benzyloxy- (BROD; CYP3A) resorufin O-dealkylases after the exposure to the cocktail of persistent organic pollutants (POPs).	Quercetin	100-109	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	188-193
28567424-9	2017	We concluded that the interactions of quercetin and naringenin with CYP1A and CYP3A in mice liver were not affected by the levels of POPs exposure.	Quercetin	38-47	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	78-83
28428963-0	2017	Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk1/2 Pathways.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	88-91
28428963-0	2017	Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk1/2 Pathways.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	96-102
28428963-6	2017	As a result, quercetin effectively inhibited the TGF-beta1-induced proliferation and transdifferentiation of the PAECs and activation of Akt/Erk1/2 cascade in the cells.	Quercetin	13-22	transforming growth factor beta 1	Homo sapiens	49-58
28428963-6	2017	As a result, quercetin effectively inhibited the TGF-beta1-induced proliferation and transdifferentiation of the PAECs and activation of Akt/Erk1/2 cascade in the cells.	Quercetin	13-22	AKT serine/threonine kinase 1	Homo sapiens	137-140
28428963-6	2017	As a result, quercetin effectively inhibited the TGF-beta1-induced proliferation and transdifferentiation of the PAECs and activation of Akt/Erk1/2 cascade in the cells.	Quercetin	13-22	mitogen-activated protein kinase 3	Homo sapiens	141-147
28428963-7	2017	In conclusion, quercetin is demonstrated to be effective for pulmonary arterial hypertension (PAH) probably by inhibiting endothelial transdifferentiation possibly via modulating Akt and Erk1/2 expressions.	Quercetin	15-24	AKT serine/threonine kinase 1	Homo sapiens	179-182
28428963-7	2017	In conclusion, quercetin is demonstrated to be effective for pulmonary arterial hypertension (PAH) probably by inhibiting endothelial transdifferentiation possibly via modulating Akt and Erk1/2 expressions.	Quercetin	15-24	mitogen-activated protein kinase 3	Homo sapiens	187-193
27771282-5	2017	Western blotting and qPCR identified two inducers of BCRP (quercetin and naringin) and two down-regulators (17-beta-estradiol and curcumin) with associated changes in BCRP efflux transport function further confirmed in both cell lines.	Quercetin	59-68	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	167-171
27771282-7	2017	These findings establish the regulatory role AhR of in controlling BCRP expression at the BBB and confirm quercetin, naringin, 17-beta-estradiol, and curcumin as novel inducers and down-regulators of BCRP gene, protein expression and functional transporter activity and hence potential novel target sites and candidates for enhancing CNS drug delivery.	Quercetin	106-115	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	200-204
29123547-0	2017	Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-kappaB Pathway.	Quercetin	0-9	mitogen-activated protein kinase 1	Mus musculus	109-112
28664744-2	2017	The aim of the present study was to investigate the effects of melatonin and quercetin on CCl4-induced steatosis characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis.	Quercetin	77-86	C-C motif chemokine ligand 4	Rattus norvegicus	90-94
29035884-8	2017	The MAPK and Wnt/beta-catenin signalling pathways were blocked prior to pretreatment with quercetin.	Quercetin	90-99	catenin (cadherin associated protein), beta 1	Mus musculus	17-29
29035884-9	2017	RESULTS: Pretreatment with quercetin significantly restored LPS-suppressed bone mineralization and the mRNA and protein expression levels of osteoblast-specific genes such as Osterix (OSX), runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin (OCN) in a dose-dependent manner.	Quercetin	27-36	Sp7 transcription factor 7	Mus musculus	175-182
29035884-9	2017	RESULTS: Pretreatment with quercetin significantly restored LPS-suppressed bone mineralization and the mRNA and protein expression levels of osteoblast-specific genes such as Osterix (OSX), runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin (OCN) in a dose-dependent manner.	Quercetin	27-36	Sp7 transcription factor 7	Mus musculus	184-187
29035884-9	2017	RESULTS: Pretreatment with quercetin significantly restored LPS-suppressed bone mineralization and the mRNA and protein expression levels of osteoblast-specific genes such as Osterix (OSX), runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin (OCN) in a dose-dependent manner.	Quercetin	27-36	runt related transcription factor 2	Mus musculus	190-225
29035884-9	2017	RESULTS: Pretreatment with quercetin significantly restored LPS-suppressed bone mineralization and the mRNA and protein expression levels of osteoblast-specific genes such as Osterix (OSX), runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin (OCN) in a dose-dependent manner.	Quercetin	27-36	runt related transcription factor 2	Mus musculus	227-232
29035884-9	2017	RESULTS: Pretreatment with quercetin significantly restored LPS-suppressed bone mineralization and the mRNA and protein expression levels of osteoblast-specific genes such as Osterix (OSX), runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin (OCN) in a dose-dependent manner.	Quercetin	27-36	bone gamma-carboxyglutamate protein 2	Mus musculus	266-277
29035884-9	2017	RESULTS: Pretreatment with quercetin significantly restored LPS-suppressed bone mineralization and the mRNA and protein expression levels of osteoblast-specific genes such as Osterix (OSX), runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin (OCN) in a dose-dependent manner.	Quercetin	27-36	bone gamma-carboxyglutamate protein 2	Mus musculus	279-282
29035884-10	2017	Pretreatment with quercetin also inhibited osteoblast apoptosis, significantly restored the down-regulated expression of Bcl-2 and Bcl-XL and decreased the upregulated expression of caspase-3, Bax, and cytochrome c in MC3T3-E1 cells induced by LPS.	Quercetin	18-27	B cell leukemia/lymphoma 2	Mus musculus	121-126
29035884-10	2017	Pretreatment with quercetin also inhibited osteoblast apoptosis, significantly restored the down-regulated expression of Bcl-2 and Bcl-XL and decreased the upregulated expression of caspase-3, Bax, and cytochrome c in MC3T3-E1 cells induced by LPS.	Quercetin	18-27	BCL2-like 1	Mus musculus	131-137
29035884-10	2017	Pretreatment with quercetin also inhibited osteoblast apoptosis, significantly restored the down-regulated expression of Bcl-2 and Bcl-XL and decreased the upregulated expression of caspase-3, Bax, and cytochrome c in MC3T3-E1 cells induced by LPS.	Quercetin	18-27	caspase 3	Mus musculus	182-191
29035884-10	2017	Pretreatment with quercetin also inhibited osteoblast apoptosis, significantly restored the down-regulated expression of Bcl-2 and Bcl-XL and decreased the upregulated expression of caspase-3, Bax, and cytochrome c in MC3T3-E1 cells induced by LPS.	Quercetin	18-27	BCL2-associated X protein	Mus musculus	193-196
29035884-11	2017	Furthermore, pretreatment with quercetin not only decreased the abundance of phosphorylated p38 MAPK and increased the abundance of phosphorylated extracellular signal regulated kinase (ERK), but also triggered the Wnt/beta-catenin pathway through enhancing expression of Wnt3 and beta-catenin.	Quercetin	31-40	mitogen-activated protein kinase 14	Mus musculus	92-100
29035884-11	2017	Furthermore, pretreatment with quercetin not only decreased the abundance of phosphorylated p38 MAPK and increased the abundance of phosphorylated extracellular signal regulated kinase (ERK), but also triggered the Wnt/beta-catenin pathway through enhancing expression of Wnt3 and beta-catenin.	Quercetin	31-40	mitogen-activated protein kinase 1	Mus musculus	147-184
29035884-11	2017	Furthermore, pretreatment with quercetin not only decreased the abundance of phosphorylated p38 MAPK and increased the abundance of phosphorylated extracellular signal regulated kinase (ERK), but also triggered the Wnt/beta-catenin pathway through enhancing expression of Wnt3 and beta-catenin.	Quercetin	31-40	mitogen-activated protein kinase 1	Mus musculus	186-189
29035884-11	2017	Furthermore, pretreatment with quercetin not only decreased the abundance of phosphorylated p38 MAPK and increased the abundance of phosphorylated extracellular signal regulated kinase (ERK), but also triggered the Wnt/beta-catenin pathway through enhancing expression of Wnt3 and beta-catenin.	Quercetin	31-40	catenin (cadherin associated protein), beta 1	Mus musculus	219-231
29035884-11	2017	Furthermore, pretreatment with quercetin not only decreased the abundance of phosphorylated p38 MAPK and increased the abundance of phosphorylated extracellular signal regulated kinase (ERK), but also triggered the Wnt/beta-catenin pathway through enhancing expression of Wnt3 and beta-catenin.	Quercetin	31-40	wingless-type MMTV integration site family, member 3	Mus musculus	272-276
29035884-11	2017	Furthermore, pretreatment with quercetin not only decreased the abundance of phosphorylated p38 MAPK and increased the abundance of phosphorylated extracellular signal regulated kinase (ERK), but also triggered the Wnt/beta-catenin pathway through enhancing expression of Wnt3 and beta-catenin.	Quercetin	31-40	catenin (cadherin associated protein), beta 1	Mus musculus	281-293
29035884-12	2017	Pretreatment with MAPK inhibitors or the Wnt/beta-catenin inhibitor XAV939 blocked the protective effects of quercetin against LPS-induced apoptosis and the inhibition of osteoblast differentiation.	Quercetin	109-118	catenin (cadherin associated protein), beta 1	Mus musculus	45-57
29227717-3	2017	Quercetin is a polyphenol that has been reported to be an active oxygen scavenger as well as a functional adenosine monophosphate-activated protein kinase (AMPK) activator.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	106-154
29227717-3	2017	Quercetin is a polyphenol that has been reported to be an active oxygen scavenger as well as a functional adenosine monophosphate-activated protein kinase (AMPK) activator.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	156-160
29227717-7	2017	In U937 cells, treatment with quercetin activated AMPK and induced expression of nuclear factor erythroid 2-related factor 2, and consequently reversed CSE-induced corticosteroid insensitivity.	Quercetin	30-39	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	50-54
29227717-7	2017	In U937 cells, treatment with quercetin activated AMPK and induced expression of nuclear factor erythroid 2-related factor 2, and consequently reversed CSE-induced corticosteroid insensitivity.	Quercetin	30-39	NFE2 like bZIP transcription factor 2	Homo sapiens	81-124
28814095-10	2017	MCF-7 cells showed a significantly increased expression of RIPK1 and RIPK3 in response to Que plus ZVAD in comparison to absence of ZVAD.	Quercetin	90-93	receptor interacting serine/threonine kinase 1	Homo sapiens	59-64
28814095-10	2017	MCF-7 cells showed a significantly increased expression of RIPK1 and RIPK3 in response to Que plus ZVAD in comparison to absence of ZVAD.	Quercetin	90-93	receptor interacting serine/threonine kinase 3	Homo sapiens	69-74
26879755-10	2017	5"-nucleotidase activity increased in the MMI/W group, but treatments with 10 or 25 mg/kg quercetin decreased 5"-nucleotidase activity.	Quercetin	90-99	5' nucleotidase, ecto	Rattus norvegicus	110-125
26879755-13	2017	In vitro tests also demonstrated that quercetin per se decreased NTPDase, 5"-nucleotidase, and AChE activities.	Quercetin	38-47	5' nucleotidase, ecto	Rattus norvegicus	74-89
26879755-13	2017	In vitro tests also demonstrated that quercetin per se decreased NTPDase, 5"-nucleotidase, and AChE activities.	Quercetin	38-47	acetylcholinesterase	Rattus norvegicus	95-99
27890642-7	2017	Quercetin supplementation decreased insulin resistance and NAFLD activity score, by reducing the intrahepatic lipid accumulation through its ability to modulate lipid metabolism gene expression, cytochrome P450 2E1 (CYP2E1)-dependent lipoperoxidation and related lipotoxicity.	Quercetin	0-9	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	195-214
27890642-7	2017	Quercetin supplementation decreased insulin resistance and NAFLD activity score, by reducing the intrahepatic lipid accumulation through its ability to modulate lipid metabolism gene expression, cytochrome P450 2E1 (CYP2E1)-dependent lipoperoxidation and related lipotoxicity.	Quercetin	0-9	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	216-222
27890642-12	2017	Quercetin reverted gut microbiota imbalance and related endotoxemia-mediated TLR-4 pathway induction, with subsequent inhibition of inflammasome response and reticulum stress pathway activation, leading to the blockage of lipid metabolism gene expression deregulation.	Quercetin	0-9	toll-like receptor 4	Mus musculus	77-82
27005763-8	2017	Mtx + quercetin group revealed significantly lower histopathological damage and APOI and caspase-3 expression decreased when compared to Mtx group.	Quercetin	6-15	caspase 3	Rattus norvegicus	89-98
29123547-0	2017	Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-kappaB Pathway.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
29123547-2	2017	The aim of the present study was to determine the protective effect of quercetin (QE) on hepatic IR injury via the ERK/NF-kappaB pathway.	Quercetin	71-80	mitogen-activated protein kinase 1	Mus musculus	115-118
29123547-2	2017	The aim of the present study was to determine the protective effect of quercetin (QE) on hepatic IR injury via the ERK/NF-kappaB pathway.	Quercetin	71-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-128
27710596-8	2017	Plasma hs-TNFalpha level was significantly reduced in the quercetin group compared to placebo (p &lt; 0.05).	Quercetin	58-67	tumor necrosis factor	Homo sapiens	10-18
27915130-0	2017	Gamma irradiation enhanced Tollip-mediated anti-inflammatory action through structural modification of quercetin in lipopolysaccharide-stimulated macrophages.	Quercetin	103-112	toll interacting protein	Homo sapiens	27-33
27915130-7	2017	The inhibitory action of intact- and gamma-irradiated quercetin on the production of IL-6 and TNF-alpha was not observed in the down-regulation of Tollip.	Quercetin	54-63	interleukin 6	Homo sapiens	85-89
27915130-7	2017	The inhibitory action of intact- and gamma-irradiated quercetin on the production of IL-6 and TNF-alpha was not observed in the down-regulation of Tollip.	Quercetin	54-63	tumor necrosis factor	Homo sapiens	94-103
27710596-11	2017	CONCLUSIONS: Five hundred milligrams per day quercetin supplementation for 8 weeks resulted in significant improvements in clinical symptoms, disease activity, hs-TNFalpha, and HAQ in women with RA.	Quercetin	45-54	tumor necrosis factor	Homo sapiens	163-171
26742515-9	2017	The inhibition of HSP70 by quercetin or HSP70 siRNA markedly attenuated the neuroprotective effects of FLZ, confirming that FLZ exerted a neuroprotective effect through HSP70.	Quercetin	27-36	heat shock protein 1B	Mus musculus	18-23
28931163-4	2017	D. melanogaster flies were divided into four groups (group I - control, group II - H2O2 (acute exposure), group III - quercetin, and group IV - quercetin + H2O2 treated).	Quercetin	144-153	l(2)41Ae	Drosophila melanogaster	133-141
28373608-6	2017	Pre-treatment with quercetin and rottlerin, PKCdelta signaling inhibitors, significantly suppressed the PMA-induced elevation of glucagon secretion.	Quercetin	19-28	protein kinase C, delta	Mus musculus	44-52
28373608-8	2017	Quercetin suppressed PMA-induced phosphorylation of Tyr311 of PKCdelta in isolated islets.	Quercetin	0-9	protein kinase C, delta	Mus musculus	62-70
27840962-5	2017	The results of this study showed that quercetin (20 muM) significantly blocked UVB irradiation (15 mJ/cm2)-induced intracellular ROS generation.	Quercetin	38-47	latexin	Homo sapiens	52-55
27615118-8	2017	This was further corroborated by the significantly low circulating TNF-alpha in the quercetin-loaded nanoparticles treated mice.	Quercetin	84-93	tumor necrosis factor	Mus musculus	67-76
27932069-7	2017	Quercetin was shown to block Pi-induced apoptosis and calcification of VSMCs by inhibiting oxidative stress and decreasing mitochondrial fission by inhibiting the expression and phosphorylation of Drp1.	Quercetin	0-9	collapsin response mediator protein 1	Rattus norvegicus	197-201
28740570-7	2017	Our results showed that quercetin downregulates the expression of EGFR and modulates this signaling pathway in spite of the activated status of EGFR as detected by the upregulation of this receptor, with respect to that observed in control rats.	Quercetin	24-33	epidermal growth factor receptor	Rattus norvegicus	66-70
28740570-8	2017	Besides, quercetin affects the phosphorylation status of Src-1, STAT5, and Sp-1.	Quercetin	9-18	nuclear receptor coactivator 1	Rattus norvegicus	57-62
28740570-8	2017	Besides, quercetin affects the phosphorylation status of Src-1, STAT5, and Sp-1.	Quercetin	9-18	signal transducer and activator of transcription 5A	Rattus norvegicus	64-69
28740570-9	2017	The better status of the liver after the treatment with quercetin could also be confirmed by the recovery in the expression of IGF-1.	Quercetin	56-65	insulin-like growth factor 1	Rattus norvegicus	127-132
28740570-10	2017	In conclusion, we suggest that quercetin reversed preneoplastic lesions by EGFR modulation and the activation state of Src, STAT5, and Sp1, so as the basal IGF-1.	Quercetin	31-40	epidermal growth factor receptor	Rattus norvegicus	75-79
28740570-10	2017	In conclusion, we suggest that quercetin reversed preneoplastic lesions by EGFR modulation and the activation state of Src, STAT5, and Sp1, so as the basal IGF-1.	Quercetin	31-40	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	119-122
28740570-10	2017	In conclusion, we suggest that quercetin reversed preneoplastic lesions by EGFR modulation and the activation state of Src, STAT5, and Sp1, so as the basal IGF-1.	Quercetin	31-40	signal transducer and activator of transcription 5A	Rattus norvegicus	124-129
28740570-10	2017	In conclusion, we suggest that quercetin reversed preneoplastic lesions by EGFR modulation and the activation state of Src, STAT5, and Sp1, so as the basal IGF-1.	Quercetin	31-40	insulin-like growth factor 1	Rattus norvegicus	156-161
28191013-0	2017	Quercetin and Quercetin-Rich Red Onion Extract Alter Pgc-1alpha Promoter Methylation and Splice Variant Expression.	Quercetin	0-9	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	53-63
28191013-0	2017	Quercetin and Quercetin-Rich Red Onion Extract Alter Pgc-1alpha Promoter Methylation and Splice Variant Expression.	Quercetin	14-23	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	53-63
28191013-2	2017	8 wks of dietary supplementation with the flavonoid quercetin (Q) or red onion extract (ROE) in a high fat diet (HFD) ameliorates HFD-induced obesity and insulin resistance in C57BL/J mice while upregulating Pgc-1alpha and increasing skeletal muscle mitochondrial number and function.	Quercetin	52-61	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	208-218
28191013-5	2017	Furthermore, Q supplementation decreased Pgc-1alpha-a expression compared to LF and HF, and ROE decreased Pgc-1alpha-a expression compared to LF.	Quercetin	13-14	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	41-51
30263475-2	2016	We examined the associations of quercetin intake and polymorphism of MATE1 in relation to metabolic syndrome (MetS) in Hallym Aging Study.	Quercetin	32-41	solute carrier family 47 member 1	Homo sapiens	69-74
30645874-1	2017	The purpose of the study was to determine the effects of curcumin (CUR) and quercetin (QUER) on the expression of genes and activity of prototypical Nrf2/ARE- and AhR/ XRE-regulated enzymes.	Quercetin	76-85	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
30645874-1	2017	The purpose of the study was to determine the effects of curcumin (CUR) and quercetin (QUER) on the expression of genes and activity of prototypical Nrf2/ARE- and AhR/ XRE-regulated enzymes.	Quercetin	76-85	aryl hydrocarbon receptor	Rattus norvegicus	154-166
27777014-1	2016	The natural flavonoid quercetin is known to activate the transcription factor Nrf2, which regulates the expression of cytoprotective enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1).	Quercetin	22-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
27777014-1	2016	The natural flavonoid quercetin is known to activate the transcription factor Nrf2, which regulates the expression of cytoprotective enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1).	Quercetin	22-31	heme oxygenase 1	Mus musculus	149-165
27777014-1	2016	The natural flavonoid quercetin is known to activate the transcription factor Nrf2, which regulates the expression of cytoprotective enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1).	Quercetin	22-31	NAD(P)H dehydrogenase, quinone 1	Mus musculus	177-209
27777014-1	2016	The natural flavonoid quercetin is known to activate the transcription factor Nrf2, which regulates the expression of cytoprotective enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1).	Quercetin	22-31	NAD(P)H dehydrogenase, quinone 1	Mus musculus	211-215
27777014-2	2016	In this study, a novel semisynthetic flavonoid 7-O-galloylquercetin (or quercetin-7-gallate, 3) was prepared by direct galloylation of quercetin, and its effect on the Nrf2 pathway was examined.	Quercetin	58-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	168-172
28077993-0	2016	Peroxisome proliferator-activated receptor gamma (PPARgamma) mediates the protective effect of quercetin against myocardial ischemia-reperfusion injury via suppressing the NF-kappaB pathway.	Quercetin	95-104	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	0-48
28174680-5	2017	Complexes of the AtGSTF2 dimer were obtained with indole-3-aldehyde, camalexin, the flavonoid quercetrin and its non-rhamnosylated analogue quercetin, at resolutions of 2.00, 2.77, 2.25 and 2.38 A respectively.	Quercetin	140-149	glutathione S-transferase PHI 2	Arabidopsis thaliana	17-24
28077993-0	2016	Peroxisome proliferator-activated receptor gamma (PPARgamma) mediates the protective effect of quercetin against myocardial ischemia-reperfusion injury via suppressing the NF-kappaB pathway.	Quercetin	95-104	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	50-59
28008970-4	2016	Here, TERS in combination with atomic force microscopy (AFM), and conventional Raman spectroscopy characterizes insulin assemblies generated during inhibition and dissection experiments in the presence of benzonitrile, dimethylsulfoxide, quercetin, and beta-carotene.	Quercetin	238-247	insulin	Homo sapiens	112-119
27621033-0	2016	Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	64-67
28077993-14	2016	GW9662 or PPARgamma knockdown partially attenuated these cardioprotective effects of quercetin during myocardial IRI.	Quercetin	85-94	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	10-19
28077993-15	2016	In conclusion, our findings suggest that quercetin ameliorated IRI-induced heart damage via PPARgamma activation and the underlying mechanism might involve the inhibition of NF-kappaB pathway by PPARgamma activation.	Quercetin	41-50	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	92-101
28077993-15	2016	In conclusion, our findings suggest that quercetin ameliorated IRI-induced heart damage via PPARgamma activation and the underlying mechanism might involve the inhibition of NF-kappaB pathway by PPARgamma activation.	Quercetin	41-50	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	195-204
27977770-3	2016	We hypothesized that mild disease found in the limb muscles of mdx mice may be responsive to quercetin-mediated protection of dystrophic muscle via PGC-1alpha pathway activation.	Quercetin	93-102	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	148-158
27621033-0	2016	Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	68-71
27621033-0	2016	Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo.	Quercetin	0-9	caspase 3	Homo sapiens	72-81
27621033-13	2016	Moreover, the expression of activated PI3K/AKT and Bcl-2 were down-regulated upon quercetin nanoparticle treatment in human neuroglioma cells.	Quercetin	82-91	AKT serine/threonine kinase 1	Homo sapiens	43-46
27694000-1	2016	The present study investigated the protective effect of quercetin (Querc) on memory, anxiety-like behavior and impairment of ectonucleotidases and acetylcholinesterase (AChE) activities in brain of streptozotocin-induced diabetic rats (STZ-diabetes).	Quercetin	56-65	acetylcholinesterase	Rattus norvegicus	147-167
27694000-8	2016	Querc 50mg/kg was more effective to prevent the increase in AChE activity in the brain of STZ-diabetes.	Quercetin	0-5	acetylcholinesterase	Rattus norvegicus	60-64
27621033-13	2016	Moreover, the expression of activated PI3K/AKT and Bcl-2 were down-regulated upon quercetin nanoparticle treatment in human neuroglioma cells.	Quercetin	82-91	BCL2 apoptosis regulator	Homo sapiens	51-56
27721177-0	2016	Novel quercetin derivative TEF induces ER stress and mitochondria-mediated apoptosis in human colon cancer HCT-116 cells.	Quercetin	6-15	TEF transcription factor, PAR bZIP family member	Homo sapiens	27-30
27621033-14	2016	The expression level of LC3 and ERK as well as cytoplasm p53, cleaved Caspase-3 and PARP was positively correlated with the concentration of quercetin nanoparticle.	Quercetin	141-150	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	24-27
27721177-2	2016	Herein, we have evaluated the apoptotic effect TEF (5, 3"-dihydroxy-3, 7, 4"-triethoxyflavone), a newly synthesized quercetin derivative on HCT-116 colon cancer cells.	Quercetin	116-125	TEF transcription factor, PAR bZIP family member	Homo sapiens	47-50
27621033-14	2016	The expression level of LC3 and ERK as well as cytoplasm p53, cleaved Caspase-3 and PARP was positively correlated with the concentration of quercetin nanoparticle.	Quercetin	141-150	mitogen-activated protein kinase 1	Homo sapiens	32-35
27621033-14	2016	The expression level of LC3 and ERK as well as cytoplasm p53, cleaved Caspase-3 and PARP was positively correlated with the concentration of quercetin nanoparticle.	Quercetin	141-150	tumor protein p53	Homo sapiens	57-60
27621033-14	2016	The expression level of LC3 and ERK as well as cytoplasm p53, cleaved Caspase-3 and PARP was positively correlated with the concentration of quercetin nanoparticle.	Quercetin	141-150	caspase 3	Homo sapiens	70-79
27756054-3	2016	The free radical scavenging activity of quercetin has been well-documented, wherein quercetin has been observed to exhibit protective effects against oxidative stress mediated neuronal damage by modulating the expression of NRF-2 dependent antioxidant responsive elements, and attenuation of neuroinflammation by suppressing NF-kappaB signal transducer and activator of transcription-1 (STAT-1).	Quercetin	40-49	NFE2 like bZIP transcription factor 2	Homo sapiens	224-229
27756054-3	2016	The free radical scavenging activity of quercetin has been well-documented, wherein quercetin has been observed to exhibit protective effects against oxidative stress mediated neuronal damage by modulating the expression of NRF-2 dependent antioxidant responsive elements, and attenuation of neuroinflammation by suppressing NF-kappaB signal transducer and activator of transcription-1 (STAT-1).	Quercetin	40-49	signal transducer and activator of transcription 1	Homo sapiens	387-393
27756054-3	2016	The free radical scavenging activity of quercetin has been well-documented, wherein quercetin has been observed to exhibit protective effects against oxidative stress mediated neuronal damage by modulating the expression of NRF-2 dependent antioxidant responsive elements, and attenuation of neuroinflammation by suppressing NF-kappaB signal transducer and activator of transcription-1 (STAT-1).	Quercetin	84-93	NFE2 like bZIP transcription factor 2	Homo sapiens	224-229
27756054-3	2016	The free radical scavenging activity of quercetin has been well-documented, wherein quercetin has been observed to exhibit protective effects against oxidative stress mediated neuronal damage by modulating the expression of NRF-2 dependent antioxidant responsive elements, and attenuation of neuroinflammation by suppressing NF-kappaB signal transducer and activator of transcription-1 (STAT-1).	Quercetin	84-93	signal transducer and activator of transcription 1	Homo sapiens	387-393
27756054-4	2016	Several in vitro and in vivo studies have also shown that quercetin destabilizes and enhances the clearance of abnormal protein such as beta- amyloid peptide and hyperphosphorlyated tau, the key pathological hallmarks of Alzheimer"s disease.	Quercetin	58-67	amyloid beta precursor protein	Homo sapiens	136-157
27756054-5	2016	Quercetin enhances neurogenesis and neuronal longevity by modulating a broad number of kinase signaling cascades such as phophoinositide 3- kinase (P13-kinase), AKT/PKB tyrosine kinase and Protein kinase C (PKC).	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	161-164
27621033-14	2016	The expression level of LC3 and ERK as well as cytoplasm p53, cleaved Caspase-3 and PARP was positively correlated with the concentration of quercetin nanoparticle.	Quercetin	141-150	collagen type XI alpha 2 chain	Homo sapiens	84-88
27621033-15	2016	In addition, p-mTOR and GAIP were obviously down-regulated by quercetin nanoparticle treatment in a dose-dependent manner.	Quercetin	62-71	mechanistic target of rapamycin kinase	Homo sapiens	15-19
27621033-16	2016	These results indicated that quercetin nanoparticle could induce autophagy and apoptosis in human neuroglioma cells, the underlying molecular mechanisms, at least partly, through activation LC3/ERK/Caspase-3 and suppression AKT/mTOR signaling.	Quercetin	29-38	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	190-193
27621033-16	2016	These results indicated that quercetin nanoparticle could induce autophagy and apoptosis in human neuroglioma cells, the underlying molecular mechanisms, at least partly, through activation LC3/ERK/Caspase-3 and suppression AKT/mTOR signaling.	Quercetin	29-38	mitogen-activated protein kinase 1	Homo sapiens	194-197
27621033-16	2016	These results indicated that quercetin nanoparticle could induce autophagy and apoptosis in human neuroglioma cells, the underlying molecular mechanisms, at least partly, through activation LC3/ERK/Caspase-3 and suppression AKT/mTOR signaling.	Quercetin	29-38	caspase 3	Homo sapiens	198-207
27621033-16	2016	These results indicated that quercetin nanoparticle could induce autophagy and apoptosis in human neuroglioma cells, the underlying molecular mechanisms, at least partly, through activation LC3/ERK/Caspase-3 and suppression AKT/mTOR signaling.	Quercetin	29-38	AKT serine/threonine kinase 1	Homo sapiens	224-227
27621033-16	2016	These results indicated that quercetin nanoparticle could induce autophagy and apoptosis in human neuroglioma cells, the underlying molecular mechanisms, at least partly, through activation LC3/ERK/Caspase-3 and suppression AKT/mTOR signaling.	Quercetin	29-38	mechanistic target of rapamycin kinase	Homo sapiens	228-232
27832996-6	2016	Results showed that: Ecto-5"-nucleotidase activity decreased in methimazole/water group and the treatment with quercetin 25mg/kg decreased NTPDase, 5"-nucleotidase and adenosine deaminase activities.	Quercetin	111-120	adenosine deaminase	Rattus norvegicus	168-187
27585526-3	2016	Quercetin at 25muM concentration significantly reduced the HUVEC expression of VCAM-1 and ICAM-1 evidently enhanced by oxLDL.	Quercetin	0-9	vascular cell adhesion molecule 1	Rattus norvegicus	79-85
27585526-3	2016	Quercetin at 25muM concentration significantly reduced the HUVEC expression of VCAM-1 and ICAM-1 evidently enhanced by oxLDL.	Quercetin	0-9	intercellular adhesion molecule 1	Rattus norvegicus	90-96
27641938-0	2016	Gold nanoparticle-conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2-mediated pathway in breast cancer.	Quercetin	29-38	epidermal growth factor receptor	Homo sapiens	117-121
27585526-4	2016	In addition, quercetin significantly downregulated the mRNA expression of MCP-1 and alleviated the nuclear translocation of NF-kappaB p65 subunit in oxLDL induced HUVECs.	Quercetin	13-22	mast cell protease 1-like 1	Rattus norvegicus	74-79
27641938-0	2016	Gold nanoparticle-conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2-mediated pathway in breast cancer.	Quercetin	29-38	kinase insert domain receptor	Homo sapiens	122-129
27585526-5	2016	Western blot and PCR analyses revealed that quercetin significantly attenuated the expression of both protein and mRNA expression of TLR2 and TLR4.	Quercetin	44-53	toll-like receptor 2	Rattus norvegicus	133-137
27585526-5	2016	Western blot and PCR analyses revealed that quercetin significantly attenuated the expression of both protein and mRNA expression of TLR2 and TLR4.	Quercetin	44-53	toll-like receptor 4	Rattus norvegicus	142-146
27585526-6	2016	Quercetin supplementation significantly decreased the inflammatory mediators like COX, 5-LOX, MPO, NOS, CRP and the mRNA expression of the cytokine; IL-6 in hypercholesterolemic diet (HCD) fed atherosclerotic rats.	Quercetin	0-9	myeloperoxidase	Rattus norvegicus	94-97
27585526-6	2016	Quercetin supplementation significantly decreased the inflammatory mediators like COX, 5-LOX, MPO, NOS, CRP and the mRNA expression of the cytokine; IL-6 in hypercholesterolemic diet (HCD) fed atherosclerotic rats.	Quercetin	0-9	C-reactive protein	Rattus norvegicus	104-107
28129681-12	2016	IL-4, IL-25, IL-33, TSLP levels in BAL and OVA-specific IgE in serum were lower in quercetin treated mice compared to untreated mice (p&lt;0.05).	Quercetin	83-92	interleukin 25	Mus musculus	6-11
27846408-5	2016	Quercetin, in both cellular systems, tend to level SOD and CAT activities, reaching basal values and could prevent lipidic peroxidation induced by gentamicin.	Quercetin	0-9	catalase	Homo sapiens	59-62
27846408-6	2016	The results in Wistar rats confirmed that therapeutic doses of gentamicin can induce oxidative stress in whole blood and that the gentamicin treatment plus quercetin can suppress ROS generation, collaborate with SOD and CAT and diminish lipid peroxidation.	Quercetin	156-165	catalase	Rattus norvegicus	220-223
28129681-11	2016	Immunohistochemical scores of IL-25, IL-33, TSLP, caspase-3 and TUNEL were lower in quercetin-treated mice  t compared to untreated mice with allergic airway inflammation (p&lt;0.05).	Quercetin	84-93	interleukin 25	Mus musculus	30-35
28129681-12	2016	IL-4, IL-25, IL-33, TSLP levels in BAL and OVA-specific IgE in serum were lower in quercetin treated mice compared to untreated mice (p&lt;0.05).	Quercetin	83-92	interleukin 33	Mus musculus	13-18
28129681-11	2016	Immunohistochemical scores of IL-25, IL-33, TSLP, caspase-3 and TUNEL were lower in quercetin-treated mice  t compared to untreated mice with allergic airway inflammation (p&lt;0.05).	Quercetin	84-93	interleukin 33	Mus musculus	37-42
28129681-11	2016	Immunohistochemical scores of IL-25, IL-33, TSLP, caspase-3 and TUNEL were lower in quercetin-treated mice  t compared to untreated mice with allergic airway inflammation (p&lt;0.05).	Quercetin	84-93	thymic stromal lymphopoietin	Mus musculus	44-48
28129681-11	2016	Immunohistochemical scores of IL-25, IL-33, TSLP, caspase-3 and TUNEL were lower in quercetin-treated mice  t compared to untreated mice with allergic airway inflammation (p&lt;0.05).	Quercetin	84-93	caspase 3	Mus musculus	50-59
28129681-12	2016	IL-4, IL-25, IL-33, TSLP levels in BAL and OVA-specific IgE in serum were lower in quercetin treated mice compared to untreated mice (p&lt;0.05).	Quercetin	83-92	interleukin 4	Mus musculus	0-4
28129681-12	2016	IL-4, IL-25, IL-33, TSLP levels in BAL and OVA-specific IgE in serum were lower in quercetin treated mice compared to untreated mice (p&lt;0.05).	Quercetin	83-92	thymic stromal lymphopoietin	Mus musculus	20-24
29949703-0	2016	Effect of quercetin on the expression of Bcl-2/Bax apoptotic proteins in endometrial cells of lipopolysaccharide-induced-abortion.	Quercetin	10-19	B cell leukemia/lymphoma 2	Mus musculus	41-46
29949703-0	2016	Effect of quercetin on the expression of Bcl-2/Bax apoptotic proteins in endometrial cells of lipopolysaccharide-induced-abortion.	Quercetin	10-19	BCL2-associated X protein	Mus musculus	47-50
29949703-1	2016	OBJECTIVE: To explore the effect of quercetin on the expressions of Bcl-2/Bax apoptotic proteins inendometrial cells in mice with abortion induced by lipopolysaccharide.	Quercetin	36-45	B cell leukemia/lymphoma 2	Mus musculus	68-73
29949703-1	2016	OBJECTIVE: To explore the effect of quercetin on the expressions of Bcl-2/Bax apoptotic proteins inendometrial cells in mice with abortion induced by lipopolysaccharide.	Quercetin	36-45	BCL2-associated X protein	Mus musculus	74-77
27213823-4	2016	Dehydrosilybin and quercetin inhibited superoxide production and MPO release from 10 mum.	Quercetin	19-28	myeloperoxidase	Equus caballus	65-68
29949703-11	2016	CONCLUSION: These results suggest that quercetin has protective effect by partially regulating the expressionof Bcl-2/Bax proteins, which in turn inhibits endometrial cell apoptosis and benefits the embryoimplantation.	Quercetin	39-48	B cell leukemia/lymphoma 2	Mus musculus	112-117
27213823-5	2016	Classical MPO assay showed quercetin as the most potent inhibitor, followed by taxifolin, dehydrosilybin and silybin.	Quercetin	27-36	myeloperoxidase	Equus caballus	10-13
27213823-7	2016	Altogether, our results showed a strong inhibition of PMN activation by planar compounds such as quercetin and dehydrosilybin and a strong inhibition of MPO activity by the smallest molecules, quercetin and taxifolin.	Quercetin	193-202	myeloperoxidase	Equus caballus	153-156
27213823-6	2016	SIEFED MPO assay highlighting the binding of tested compounds to MPO showed that only quercetin and taxifolin maintained an efficient inhibition above 90% at 10 mum.	Quercetin	86-95	myeloperoxidase	Equus caballus	7-10
29949703-11	2016	CONCLUSION: These results suggest that quercetin has protective effect by partially regulating the expressionof Bcl-2/Bax proteins, which in turn inhibits endometrial cell apoptosis and benefits the embryoimplantation.	Quercetin	39-48	BCL2-associated X protein	Mus musculus	118-121
27213823-6	2016	SIEFED MPO assay highlighting the binding of tested compounds to MPO showed that only quercetin and taxifolin maintained an efficient inhibition above 90% at 10 mum.	Quercetin	86-95	myeloperoxidase	Equus caballus	65-68
27665434-9	2016	TLR4 inhibition study confirmed the downstream signaling mechanism mediated by NF-kappaB which is involved in the oxLDL-induced inflammatory response, and quercetin suppresses the cytokine, TNF-alpha release by modulating TLR-NF-kappaB signaling pathway.	Quercetin	155-164	tumor necrosis factor	Rattus norvegicus	190-199
27665434-10	2016	In addition to NF-kappaB signaling pathway, inflammation induced by oxLDL was also related to the activation of p38MAPK, ERK1/2 and JNK, and Akt pathways, and the protective effect of quercetin may be also related to the inhibition of activation of these pathways.	Quercetin	184-193	mitogen activated protein kinase 3	Rattus norvegicus	121-127
27665434-10	2016	In addition to NF-kappaB signaling pathway, inflammation induced by oxLDL was also related to the activation of p38MAPK, ERK1/2 and JNK, and Akt pathways, and the protective effect of quercetin may be also related to the inhibition of activation of these pathways.	Quercetin	184-193	mitogen-activated protein kinase 8	Rattus norvegicus	132-135
27665434-10	2016	In addition to NF-kappaB signaling pathway, inflammation induced by oxLDL was also related to the activation of p38MAPK, ERK1/2 and JNK, and Akt pathways, and the protective effect of quercetin may be also related to the inhibition of activation of these pathways.	Quercetin	184-193	AKT serine/threonine kinase 1	Rattus norvegicus	141-144
27665434-11	2016	Quercetin significantly downregulated the elevated mRNA expression of TLRs and cytokine TNF-alpha in HCD-fed atherosclerotic rats in vivo.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	88-97
27665434-12	2016	As quercetin possesses inhibition on both TLR-NF-kappaB signaling pathway and TLR-mediated MAPK pathway, it is evident that it can be used as a therapeutic agent to ameliorate atherosclerotic inflammation.	Quercetin	3-12	mitogen activated protein kinase 3	Rattus norvegicus	91-95
27572285-5	2016	Quercetin (10-40 muM) effects on the expression of Bcl-2, caspase-9, caspase-3, PARP-1, PERK, IRE1, ATF6, calnexin and CHOP for 24 h were analyzed by Western blot.	Quercetin	0-9	BCL2, apoptosis regulator	Rattus norvegicus	51-56
27909560-0	2016	Induction of heme oxygenase-1 with dietary quercetin reduces obesity-induced hepatic inflammation through macrophage phenotype switching.	Quercetin	43-52	heme oxygenase 1	Mus musculus	13-29
27909560-3	2016	Here, we show that the flavonoid quercetin reduces obesity-induced hepatic inflammation by inducing HO-1, which promotes hepatic macrophage polarization in favor of the M2 phenotype.	Quercetin	33-42	heme oxygenase 1	Mus musculus	100-104
27909560-7	2016	RESULTS: Quercetin supplementation decreased levels of inflammatory cytokines (TNFalpha, IL-6) and increased that of the anti-inflammatory cytokine (IL-10) in the livers of HFD-fed mice.	Quercetin	9-18	tumor necrosis factor	Mus musculus	79-87
27909560-7	2016	RESULTS: Quercetin supplementation decreased levels of inflammatory cytokines (TNFalpha, IL-6) and increased that of the anti-inflammatory cytokine (IL-10) in the livers of HFD-fed mice.	Quercetin	9-18	interleukin 6	Mus musculus	89-93
27909560-7	2016	RESULTS: Quercetin supplementation decreased levels of inflammatory cytokines (TNFalpha, IL-6) and increased that of the anti-inflammatory cytokine (IL-10) in the livers of HFD-fed mice.	Quercetin	9-18	interleukin 10	Mus musculus	149-154
27909560-9	2016	In co-cultures of lipid-laden hepatocytes and macrophages, treatment with quercetin induced HO-1 in the macrophages, markedly suppressed expression of M1 macrophage marker genes, and reduced release of MCP-1.	Quercetin	74-83	heme oxygenase 1	Mus musculus	92-96
27909560-9	2016	In co-cultures of lipid-laden hepatocytes and macrophages, treatment with quercetin induced HO-1 in the macrophages, markedly suppressed expression of M1 macrophage marker genes, and reduced release of MCP-1.	Quercetin	74-83	mast cell protease 1	Mus musculus	202-207
27909560-10	2016	Moreover, these effects of quercetin were blunted by an HO-1 inhibitor and deficiency of nuclear factor E2-related factor 2 (Nrf2) in macrophages.	Quercetin	27-36	heme oxygenase 1	Mus musculus	56-60
27909560-10	2016	Moreover, these effects of quercetin were blunted by an HO-1 inhibitor and deficiency of nuclear factor E2-related factor 2 (Nrf2) in macrophages.	Quercetin	27-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-129
27909560-12	2016	The beneficial effect of quercetin is associated with Nrf2-mediated HO-1 induction.	Quercetin	25-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
27909560-12	2016	The beneficial effect of quercetin is associated with Nrf2-mediated HO-1 induction.	Quercetin	25-34	heme oxygenase 1	Mus musculus	68-72
27572285-9	2016	Quercetin induced downregulation of Bcl-2 and upregulation of Bax, and increased cytochrome C in the cytoplasm in HSCs.	Quercetin	0-9	BCL2, apoptosis regulator	Rattus norvegicus	36-41
27572285-9	2016	Quercetin induced downregulation of Bcl-2 and upregulation of Bax, and increased cytochrome C in the cytoplasm in HSCs.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Rattus norvegicus	62-65
27572285-10	2016	The cleaved forms of caspase-9, caspase-3 and PARP-1 were also increased by quercetin.	Quercetin	76-85	caspase 9	Rattus norvegicus	21-30
27572285-10	2016	The cleaved forms of caspase-9, caspase-3 and PARP-1 were also increased by quercetin.	Quercetin	76-85	caspase 3	Rattus norvegicus	32-41
27572285-10	2016	The cleaved forms of caspase-9, caspase-3 and PARP-1 were also increased by quercetin.	Quercetin	76-85	poly (ADP-ribose) polymerase 1	Rattus norvegicus	46-52
27572285-11	2016	Furthermore, quercetin elevated mRNA and protein expression of calnexin and CHOP in HSCs but not in hepatocytes.	Quercetin	13-22	calnexin	Rattus norvegicus	63-71
27572285-11	2016	Furthermore, quercetin elevated mRNA and protein expression of calnexin and CHOP in HSCs but not in hepatocytes.	Quercetin	13-22	DNA-damage inducible transcript 3	Rattus norvegicus	76-80
27572285-12	2016	Quercetin also increased phosphorylation of PERK and IRE1 and ATF6 cleavage.	Quercetin	0-9	activating transcription factor 6	Rattus norvegicus	62-66
27572285-5	2016	Quercetin (10-40 muM) effects on the expression of Bcl-2, caspase-9, caspase-3, PARP-1, PERK, IRE1, ATF6, calnexin and CHOP for 24 h were analyzed by Western blot.	Quercetin	0-9	caspase 9	Rattus norvegicus	58-67
27572285-5	2016	Quercetin (10-40 muM) effects on the expression of Bcl-2, caspase-9, caspase-3, PARP-1, PERK, IRE1, ATF6, calnexin and CHOP for 24 h were analyzed by Western blot.	Quercetin	0-9	caspase 3	Rattus norvegicus	69-78
27572285-5	2016	Quercetin (10-40 muM) effects on the expression of Bcl-2, caspase-9, caspase-3, PARP-1, PERK, IRE1, ATF6, calnexin and CHOP for 24 h were analyzed by Western blot.	Quercetin	0-9	poly (ADP-ribose) polymerase 1	Rattus norvegicus	80-86
27572285-5	2016	Quercetin (10-40 muM) effects on the expression of Bcl-2, caspase-9, caspase-3, PARP-1, PERK, IRE1, ATF6, calnexin and CHOP for 24 h were analyzed by Western blot.	Quercetin	0-9	activating transcription factor 6	Rattus norvegicus	100-104
27572285-5	2016	Quercetin (10-40 muM) effects on the expression of Bcl-2, caspase-9, caspase-3, PARP-1, PERK, IRE1, ATF6, calnexin and CHOP for 24 h were analyzed by Western blot.	Quercetin	0-9	calnexin	Rattus norvegicus	106-114
27572285-5	2016	Quercetin (10-40 muM) effects on the expression of Bcl-2, caspase-9, caspase-3, PARP-1, PERK, IRE1, ATF6, calnexin and CHOP for 24 h were analyzed by Western blot.	Quercetin	0-9	DNA-damage inducible transcript 3	Rattus norvegicus	119-123
27572285-6	2016	Quercetin (10-40 muM) effects on mRNA expression of calnexin and CHOP for 24 h were analyzed by Real-time PCR.	Quercetin	0-9	calnexin	Rattus norvegicus	52-60
27572285-6	2016	Quercetin (10-40 muM) effects on mRNA expression of calnexin and CHOP for 24 h were analyzed by Real-time PCR.	Quercetin	0-9	DNA-damage inducible transcript 3	Rattus norvegicus	65-69
27823633-8	2016	Expression of EMT markers, such as E-, N-cadherin, beta-catenin, and snail, were regulated by non-toxic concentrations of quercetin.	Quercetin	122-131	cadherin 2	Mus musculus	39-49
27639810-8	2016	Quercetin, EGCG and C3G effectively inhibited alpha-synuclein fibrillation over the relevant timescale applied here.	Quercetin	0-9	synuclein alpha	Homo sapiens	46-61
27823633-8	2016	Expression of EMT markers, such as E-, N-cadherin, beta-catenin, and snail, were regulated by non-toxic concentrations of quercetin.	Quercetin	122-131	catenin (cadherin associated protein), beta 1	Mus musculus	51-63
27932986-7	2016	Ex vivo studies indicated that application of quercetin to mouse ileum and colon on serosal side resulted in activation of CFTR and CaCC-mediated Cl- currents.	Quercetin	46-55	cystic fibrosis transmembrane conductance regulator	Mus musculus	123-127
27932986-8	2016	Notably, we found that quercetin exhibited inhibitory effect against ANO1 chloride channel activity in ANO1-expressing FRT cells and decreased mouse intestinal motility.	Quercetin	23-32	anoctamin 1, calcium activated chloride channel	Mus musculus	69-73
27932986-8	2016	Notably, we found that quercetin exhibited inhibitory effect against ANO1 chloride channel activity in ANO1-expressing FRT cells and decreased mouse intestinal motility.	Quercetin	23-32	anoctamin 1, calcium activated chloride channel	Mus musculus	103-107
27932986-12	2016	The inverse effects of quercetin on CaCCs provided evidence that ANO1 and intestinal epithelial CaCCs are different calcium-activated chloride channels.	Quercetin	23-32	anoctamin 1, calcium activated chloride channel	Mus musculus	65-69
27716626-0	2016	Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFalpha secretion.	Quercetin	60-69	tumor necrosis factor	Homo sapiens	94-102
27716626-4	2016	In numerous studies, polyphenols, including quercetin, demonstrated their ability to suppress TNFalpha secretion and protect from the onset of chronic inflammatory disorders.	Quercetin	44-53	tumor necrosis factor	Homo sapiens	94-102
27765347-0	2016	Neurohormetic responses of quercetin and rutin in a cell line over-expressing the amyloid precursor protein (APPswe cells).	Quercetin	27-36	amyloid beta precursor protein	Homo sapiens	82-107
27716626-5	2016	We show that murine bone marrow derived DCs express Slpi following quercetin exposure.	Quercetin	67-76	secretory leukocyte peptidase inhibitor	Mus musculus	52-56
27765347-3	2016	PURPOSE: We attempt to explore the molecular mechanisms involved in the neurohormetic responses to quercetin and rutin exposure, in a SH-SY5Y cell line which stably overexpresses the amyloid precursor protein (APP) Swedish mutation, based on a biphasic concentration-response relationship for cell viability.	Quercetin	99-108	amyloid beta precursor protein	Homo sapiens	183-208
27765347-6	2016	Activity of caspase-3 was significantly attenuated by treatment with quercetin or rutin.	Quercetin	69-78	caspase 3	Homo sapiens	12-21
27716626-8	2016	Supernatant from quercetin exposed DCs could also reduce LPS-mediated TNFalpha secretion by unrelated DCs, but this property is lost using an anti-Slpi antibody.	Quercetin	17-26	tumor necrosis factor	Homo sapiens	70-78
27765347-10	2016	CONCLUSIONS: The upregulation of the proteasome activity observed upon quercetin or rutin treatment could be afforded by a mild increased of PARP-1.	Quercetin	71-80	poly(ADP-ribose) polymerase 1	Homo sapiens	141-147
27716626-8	2016	Supernatant from quercetin exposed DCs could also reduce LPS-mediated TNFalpha secretion by unrelated DCs, but this property is lost using an anti-Slpi antibody.	Quercetin	17-26	secretory leukocyte peptidase inhibitor	Homo sapiens	147-151
27716626-9	2016	In vivo, oral administration of quercetin is able to induce Slpi expression.	Quercetin	32-41	secretory leukocyte peptidase inhibitor	Homo sapiens	60-64
27716626-10	2016	Human biopsies from inflamed tract of the intestine reveal the presence of numerous SLPI+ cells and the expression level could be further increased by quercetin administration.	Quercetin	151-160	secretory leukocyte peptidase inhibitor	Homo sapiens	84-88
27716626-11	2016	We propose that quercetin induces Slpi expression that in turn reduces the inflammatory response.	Quercetin	16-25	secretory leukocyte peptidase inhibitor	Homo sapiens	34-38
27601294-0	2016	Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-kappaB signaling pathways.	Quercetin	0-9	high mobility group box 1	Mus musculus	111-116
28955981-8	2016	Furthermore, quercetin suppressed the transient increase of Akt phosphorylation induced by the stimulation of macrophage colony-stimulating factor and receptor activator of NF-kappaB ligand with no effect on MAPK phosphorylation, suggesting exquisite crosstalk between cytokine receptor and G-protein coupled receptor signaling.	Quercetin	13-22	AKT serine/threonine kinase 1	Homo sapiens	60-63
27601294-0	2016	Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-kappaB signaling pathways.	Quercetin	0-9	toll-like receptor 2	Mus musculus	117-121
27601294-3	2016	Here, we demonstrated that quercetin dramatically ameliorated liver injury, inflammation, and hepatic fibrogenesis induced by CCl4.	Quercetin	27-36	chemokine (C-C motif) ligand 4	Mus musculus	126-130
27601294-4	2016	Quercetin also inhibited the activation of hepatic stellate cells (HSC) in vivo and in vitro, as evaluated by alpha-smooth muscle actin (alpha-SMA) expression, which is a specific marker of HSC activation.	Quercetin	0-9	actin alpha 2, smooth muscle, aorta	Mus musculus	110-135
27601294-4	2016	Quercetin also inhibited the activation of hepatic stellate cells (HSC) in vivo and in vitro, as evaluated by alpha-smooth muscle actin (alpha-SMA) expression, which is a specific marker of HSC activation.	Quercetin	0-9	actin alpha 2, smooth muscle, aorta	Mus musculus	137-146
27601294-6	2016	Quercetin also inhibited the cytoplasmic translocation of HMGB1 in hepatocytes of fibrotic livers.	Quercetin	0-9	high mobility group box 1	Mus musculus	58-63
27601294-7	2016	Further investigation demonstrated that quercetin treatment significantly attenuated CCl4-induced nuclear translocation of the nuclear factor-kappaB (NF-kappaB) p65 and inhibited degradation of IkappaBalpha (an inhibitor of NF-kappaB) expression in the liver compared with vehicle-treated fibrotic mice.	Quercetin	40-49	chemokine (C-C motif) ligand 4	Mus musculus	85-89
27601294-7	2016	Further investigation demonstrated that quercetin treatment significantly attenuated CCl4-induced nuclear translocation of the nuclear factor-kappaB (NF-kappaB) p65 and inhibited degradation of IkappaBalpha (an inhibitor of NF-kappaB) expression in the liver compared with vehicle-treated fibrotic mice.	Quercetin	40-49	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	161-164
27601294-7	2016	Further investigation demonstrated that quercetin treatment significantly attenuated CCl4-induced nuclear translocation of the nuclear factor-kappaB (NF-kappaB) p65 and inhibited degradation of IkappaBalpha (an inhibitor of NF-kappaB) expression in the liver compared with vehicle-treated fibrotic mice.	Quercetin	40-49	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	194-206
27601294-8	2016	Considered together, our data indicate that quercetin has hepatoprotective and anti-fibrotic effects in animal models of liver fibrosis, the mechanism of which may be involved in modulating the HMGB1-TLR2/4-NF-kappaB signaling pathways.	Quercetin	44-53	high mobility group box 1	Mus musculus	194-199
27601294-8	2016	Considered together, our data indicate that quercetin has hepatoprotective and anti-fibrotic effects in animal models of liver fibrosis, the mechanism of which may be involved in modulating the HMGB1-TLR2/4-NF-kappaB signaling pathways.	Quercetin	44-53	toll-like receptor 2	Mus musculus	200-204
28032729-5	2016	Results: Quercetin elicitedsignificant reduction in serum TAG72 and GAL3 levels, in addition to significant suppression of colonic Wnt5a geneexpression and amplification of colonic Axin-1 gene expression.	Quercetin	9-18	galectin 3	Rattus norvegicus	68-72
27704720-0	2016	Quercetin suppresses lung cancer growth by targeting Aurora B kinase.	Quercetin	0-9	aurora kinase C	Mus musculus	53-61
27704720-3	2016	Herein, we report for the first time that quercetin inhibited aurora B activities by directly binding with aurora B in vitro and in vivo.	Quercetin	42-51	aurora kinase C	Mus musculus	62-70
27704720-3	2016	Herein, we report for the first time that quercetin inhibited aurora B activities by directly binding with aurora B in vitro and in vivo.	Quercetin	42-51	aurora kinase C	Mus musculus	107-115
27704720-4	2016	Ex vivo studies showed that quercetin inhibited aurora B activities in JB6 Cl41 cells and A549 lung cancer cells.	Quercetin	28-37	aurora kinase C	Mus musculus	48-56
27704720-5	2016	Moreover, knockdown of aurora B in A549 cells decreased their sensitivities to quercetin.	Quercetin	79-88	aurora kinase C	Mus musculus	23-31
27704720-8	2016	In short, quercetin can suppress growth of lung cancer cells as an aurora B inhibitor both in vitro and in vivo.	Quercetin	10-19	aurora kinase C	Mus musculus	67-75
27405734-3	2016	The quercetin 3,7-O-dimethyl ether (QDE) isolated from the herbs of S. pubescens suppressed the lipopolysaccharide (LPS)-induced nitric oxide and inducible nitric oxide synthase (iNOS) protein production in mouse macrophages.	Quercetin	4-13	nitric oxide synthase 2	Homo sapiens	179-183
28032729-5	2016	Results: Quercetin elicitedsignificant reduction in serum TAG72 and GAL3 levels, in addition to significant suppression of colonic Wnt5a geneexpression and amplification of colonic Axin-1 gene expression.	Quercetin	9-18	Wnt family member 5A	Rattus norvegicus	131-136
28032729-5	2016	Results: Quercetin elicitedsignificant reduction in serum TAG72 and GAL3 levels, in addition to significant suppression of colonic Wnt5a geneexpression and amplification of colonic Axin-1 gene expression.	Quercetin	9-18	axin 1	Rattus norvegicus	181-187
27271803-2	2016	The present results have shown that quercetin and isoquercetin inhibit the enzymatic activity of thrombin and FXa and suppress fibrin clot formation and blood clotting.	Quercetin	36-45	coagulation factor II	Mus musculus	97-105
28026003-0	2016	Quercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1.	Quercetin	0-9	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	112-118
28026003-14	2016	The findings of our study indicate that quercetin promotes RAFLS apoptosis by upregulating lncRNA MALAT1, and that MALAT1 induces apoptosis by inhibiting the activation of the PI3K/AKT pathway.	Quercetin	40-49	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	98-104
27271803-4	2016	The in vivo and ex vivo anticoagulant efficacy of quercetin and isoquercetin was evaluated in thrombin-induced acute thromboembolism model and in ICR mice.	Quercetin	50-59	coagulation factor II	Mus musculus	94-102
26609631-0	2016	Quercetin inhibits multiple pathways involved in interleukin 6 secretion from human lung fibroblasts and activity in bronchial epithelial cell transformation induced by benzo[a]pyrene diol epoxide.	Quercetin	0-9	interleukin 6	Homo sapiens	49-62
26609631-7	2016	We further show that quercetin, a dietary compound having preventive properties for lung cancer, decreased BPDE-stimulated IL-6 secretion from human lung fibroblasts through inhibition of the NF-kappaB and ERK pathways.	Quercetin	21-30	interleukin 6	Homo sapiens	123-127
27665716-10	2016	Therefore, the results of the present study indicated that the natural products, CA, quercetin and morin hydrate, offer potential as adjuvant therapeutic agents for SM-induced toxicity, not only by reducing inflammation mediated by the p38 and LOX signaling pathways, but also by decreasing the generation of ROS and nitrate/nitrite.	Quercetin	85-94	mitogen-activated protein kinase 14	Homo sapiens	236-239
26609631-7	2016	We further show that quercetin, a dietary compound having preventive properties for lung cancer, decreased BPDE-stimulated IL-6 secretion from human lung fibroblasts through inhibition of the NF-kappaB and ERK pathways.	Quercetin	21-30	mitogen-activated protein kinase 1	Homo sapiens	206-209
26609631-9	2016	Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment.	Quercetin	9-18	interleukin 6	Homo sapiens	27-31
26609631-9	2016	Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment.	Quercetin	9-18	signal transducer and activator of transcription 3	Homo sapiens	40-45
26609631-9	2016	Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment.	Quercetin	136-145	interleukin 6	Homo sapiens	27-31
26609631-9	2016	Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment.	Quercetin	136-145	signal transducer and activator of transcription 3	Homo sapiens	40-45
26609631-9	2016	Finally, quercetin blocked IL-6-induced STAT3 activation in HBECs, and IL-6 enhancement of HBEC transformation by BPDE was abolished by quercetin treatment.	Quercetin	136-145	interleukin 6	Homo sapiens	71-75
27748879-0	2016	Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	78-81
27665716-10	2016	Therefore, the results of the present study indicated that the natural products, CA, quercetin and morin hydrate, offer potential as adjuvant therapeutic agents for SM-induced toxicity, not only by reducing inflammation mediated by the p38 and LOX signaling pathways, but also by decreasing the generation of ROS and nitrate/nitrite.	Quercetin	85-94	lysyl oxidase	Homo sapiens	244-247
27748879-0	2016	Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis.	Quercetin	0-9	COP9 signalosome subunit 6	Homo sapiens	82-86
27690831-0	2016	Quercetin attenuates neuronal autophagy and apoptosis in rat traumatic brain injury model via activation of PI3K/Akt signaling pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
27748879-0	2016	Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis.	Quercetin	0-9	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	87-90
27748879-8	2016	Western blot analysis revealed that quercetin reduced the protein expression levels of phosphorylated-Akt and increased CSN6 protein degradation; therefore, affecting the expression levels of Myc, p53, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein.	Quercetin	36-45	AKT serine/threonine kinase 1	Homo sapiens	102-105
27748879-8	2016	Western blot analysis revealed that quercetin reduced the protein expression levels of phosphorylated-Akt and increased CSN6 protein degradation; therefore, affecting the expression levels of Myc, p53, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein.	Quercetin	36-45	COP9 signalosome subunit 6	Homo sapiens	120-124
27748879-8	2016	Western blot analysis revealed that quercetin reduced the protein expression levels of phosphorylated-Akt and increased CSN6 protein degradation; therefore, affecting the expression levels of Myc, p53, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein.	Quercetin	36-45	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	192-195
27748879-8	2016	Western blot analysis revealed that quercetin reduced the protein expression levels of phosphorylated-Akt and increased CSN6 protein degradation; therefore, affecting the expression levels of Myc, p53, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein.	Quercetin	36-45	tumor protein p53	Homo sapiens	197-200
27748879-8	2016	Western blot analysis revealed that quercetin reduced the protein expression levels of phosphorylated-Akt and increased CSN6 protein degradation; therefore, affecting the expression levels of Myc, p53, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein.	Quercetin	36-45	BCL2 apoptosis regulator	Homo sapiens	202-219
27748879-8	2016	Western blot analysis revealed that quercetin reduced the protein expression levels of phosphorylated-Akt and increased CSN6 protein degradation; therefore, affecting the expression levels of Myc, p53, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein.	Quercetin	36-45	BCL2 apoptosis regulator	Homo sapiens	221-226
27748879-8	2016	Western blot analysis revealed that quercetin reduced the protein expression levels of phosphorylated-Akt and increased CSN6 protein degradation; therefore, affecting the expression levels of Myc, p53, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein.	Quercetin	36-45	BCL2 apoptosis regulator	Homo sapiens	232-237
27748879-9	2016	The overexpression of CSN6 reduced the effect of quercetin treatment on HT-29 cells, suggesting that quercetin-induced apoptosis may involve the Akt-CSN6-Myc signaling axis in HT-29 cells.	Quercetin	49-58	COP9 signalosome subunit 6	Homo sapiens	22-26
27748879-9	2016	The overexpression of CSN6 reduced the effect of quercetin treatment on HT-29 cells, suggesting that quercetin-induced apoptosis may involve the Akt-CSN6-Myc signaling axis in HT-29 cells.	Quercetin	49-58	AKT serine/threonine kinase 1	Homo sapiens	145-148
27748879-9	2016	The overexpression of CSN6 reduced the effect of quercetin treatment on HT-29 cells, suggesting that quercetin-induced apoptosis may involve the Akt-CSN6-Myc signaling axis in HT-29 cells.	Quercetin	49-58	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	154-157
27748879-9	2016	The overexpression of CSN6 reduced the effect of quercetin treatment on HT-29 cells, suggesting that quercetin-induced apoptosis may involve the Akt-CSN6-Myc signaling axis in HT-29 cells.	Quercetin	101-110	COP9 signalosome subunit 6	Homo sapiens	22-26
27748879-9	2016	The overexpression of CSN6 reduced the effect of quercetin treatment on HT-29 cells, suggesting that quercetin-induced apoptosis may involve the Akt-CSN6-Myc signaling axis in HT-29 cells.	Quercetin	101-110	AKT serine/threonine kinase 1	Homo sapiens	145-148
27748879-9	2016	The overexpression of CSN6 reduced the effect of quercetin treatment on HT-29 cells, suggesting that quercetin-induced apoptosis may involve the Akt-CSN6-Myc signaling axis in HT-29 cells.	Quercetin	101-110	COP9 signalosome subunit 6	Homo sapiens	149-153
27748879-9	2016	The overexpression of CSN6 reduced the effect of quercetin treatment on HT-29 cells, suggesting that quercetin-induced apoptosis may involve the Akt-CSN6-Myc signaling axis in HT-29 cells.	Quercetin	101-110	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	154-157
27690831-11	2016	Furthermore, quercetin treatment reduced the expression of LC3 caspase-3 and Bax levels induced following TBI (p &lt; 0.05), and increased the expression of p-Akt and Bcl-2 at 48 h (p &lt; 0.05).	Quercetin	13-22	annexin A3	Rattus norvegicus	59-62
27690831-11	2016	Furthermore, quercetin treatment reduced the expression of LC3 caspase-3 and Bax levels induced following TBI (p &lt; 0.05), and increased the expression of p-Akt and Bcl-2 at 48 h (p &lt; 0.05).	Quercetin	13-22	caspase 3	Rattus norvegicus	63-72
27690831-11	2016	Furthermore, quercetin treatment reduced the expression of LC3 caspase-3 and Bax levels induced following TBI (p &lt; 0.05), and increased the expression of p-Akt and Bcl-2 at 48 h (p &lt; 0.05).	Quercetin	13-22	BCL2 associated X, apoptosis regulator	Rattus norvegicus	77-80
27690831-11	2016	Furthermore, quercetin treatment reduced the expression of LC3 caspase-3 and Bax levels induced following TBI (p &lt; 0.05), and increased the expression of p-Akt and Bcl-2 at 48 h (p &lt; 0.05).	Quercetin	13-22	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
27690831-11	2016	Furthermore, quercetin treatment reduced the expression of LC3 caspase-3 and Bax levels induced following TBI (p &lt; 0.05), and increased the expression of p-Akt and Bcl-2 at 48 h (p &lt; 0.05).	Quercetin	13-22	BCL2, apoptosis regulator	Rattus norvegicus	167-172
27690831-13	2016	The neuroprotective effects of quercetin may be related to modulation of PI3K/Akt signaling pathway.	Quercetin	31-40	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
27690831-3	2016	However, whether PI3K/Akt signaling pathway mediates the neuroprotection of quercetin following TBI is not well clarified.	Quercetin	76-85	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
27690831-4	2016	We sought to propose a hypothesis that quercetin could attenuate neuronal autophagy and apoptosis via enhancing PI3K/Akt signaling.	Quercetin	39-48	AKT serine/threonine kinase 1	Rattus norvegicus	117-120
27690831-10	2016	Double immunolabeling demonstrated that quercetin significantly reduced the LC3-positive cells co-labeled with NeuN, whereas significantly enhanced p-Akt-positive cells co-labeled with NeuN.	Quercetin	40-49	annexin A3	Rattus norvegicus	76-79
27690831-10	2016	Double immunolabeling demonstrated that quercetin significantly reduced the LC3-positive cells co-labeled with NeuN, whereas significantly enhanced p-Akt-positive cells co-labeled with NeuN.	Quercetin	40-49	RNA binding fox-1 homolog 3	Rattus norvegicus	111-115
27690831-10	2016	Double immunolabeling demonstrated that quercetin significantly reduced the LC3-positive cells co-labeled with NeuN, whereas significantly enhanced p-Akt-positive cells co-labeled with NeuN.	Quercetin	40-49	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
28167483-8	2016	Furthermore, quercetin induced a significantly decrease of human sperm [Ca2+]i after 2 min above 50 muM, and dose-dependently decreased the protein-tyrosine phosphorylation of human sperm.	Quercetin	13-22	latexin	Homo sapiens	100-103
27513201-5	2016	Pretreatment for 1 h with quercetin before dieldrin application could significantly suppress dieldrin-induced apoptotic characteristics, including nuclear condensation, DNA fragmentation, and caspase-3/7 activation.	Quercetin	26-35	caspase 3	Mus musculus	192-201
27780244-0	2016	Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway.	Quercetin	22-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	107-111
27780244-1	2016	The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in mitochondrial biogenesis.	Quercetin	122-131	nuclear factor, erythroid derived 2, like 2	Mus musculus	263-306
27780244-1	2016	The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in mitochondrial biogenesis.	Quercetin	122-131	nuclear factor, erythroid derived 2, like 2	Mus musculus	308-312
27780244-7	2016	Quercetin treatment resulted in an upregulation of Nrf2 expression and cytochrome c, malondialdehyde (MDA) and superoxide dismutase (SOD) levels were restored by quercetin treatment.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-55
27780244-7	2016	Quercetin treatment resulted in an upregulation of Nrf2 expression and cytochrome c, malondialdehyde (MDA) and superoxide dismutase (SOD) levels were restored by quercetin treatment.	Quercetin	162-171	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-55
27780244-8	2016	Quercetin markedly promoted the translocation of Nrf2 protein from the cytoplasm to the nucleus.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
27780244-9	2016	These observations suggest that quercetin improves mitochondrial function in TBI models, possibly by activating the Nrf2 pathway.	Quercetin	32-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
27775094-8	2016	After oral administration of 100 mg/kg quercetin or 100 mg/kg Q3G in rats, predominantly Q3G was detected in plasma with AUC at 39529.2 +- 6108.2 mg h L-1 or 24625.1 +- 1563.8 mg h L-1, 18-fold higher than quercetin with AUC at 1583.9 +- 583.3 mg h L-1 or 1394.6 +- 868.1 mg h L-1, respectively.	Quercetin	39-48	ribosomal protein L4	Rattus norvegicus	181-184
27775094-8	2016	After oral administration of 100 mg/kg quercetin or 100 mg/kg Q3G in rats, predominantly Q3G was detected in plasma with AUC at 39529.2 +- 6108.2 mg h L-1 or 24625.1 +- 1563.8 mg h L-1, 18-fold higher than quercetin with AUC at 1583.9 +- 583.3 mg h L-1 or 1394.6 +- 868.1 mg h L-1, respectively.	Quercetin	39-48	ribosomal protein L4	Rattus norvegicus	181-184
27843913-6	2016	Quercetin is readily metabolized by tyrosinase into various compounds that promote anticancer activity; additionally, given that tyrosinase expression increases during tumorigenesis, and its activity is associated with pigmentation changes in both early- and late-stage melanocytic lesions, it suggests that quercetin can be used to target melanoma.	Quercetin	0-9	tyrosinase	Homo sapiens	36-46
27843913-6	2016	Quercetin is readily metabolized by tyrosinase into various compounds that promote anticancer activity; additionally, given that tyrosinase expression increases during tumorigenesis, and its activity is associated with pigmentation changes in both early- and late-stage melanocytic lesions, it suggests that quercetin can be used to target melanoma.	Quercetin	0-9	tyrosinase	Homo sapiens	129-139
27843913-6	2016	Quercetin is readily metabolized by tyrosinase into various compounds that promote anticancer activity; additionally, given that tyrosinase expression increases during tumorigenesis, and its activity is associated with pigmentation changes in both early- and late-stage melanocytic lesions, it suggests that quercetin can be used to target melanoma.	Quercetin	308-317	tyrosinase	Homo sapiens	36-46
27843913-6	2016	Quercetin is readily metabolized by tyrosinase into various compounds that promote anticancer activity; additionally, given that tyrosinase expression increases during tumorigenesis, and its activity is associated with pigmentation changes in both early- and late-stage melanocytic lesions, it suggests that quercetin can be used to target melanoma.	Quercetin	308-317	tyrosinase	Homo sapiens	129-139
27843913-9	2016	In general, quercetin could be used to exploit tyrosinase activity to prevent, and/or treat, melanoma with minimal additional side effects.	Quercetin	12-21	tyrosinase	Homo sapiens	47-57
27775094-8	2016	After oral administration of 100 mg/kg quercetin or 100 mg/kg Q3G in rats, predominantly Q3G was detected in plasma with AUC at 39529.2 +- 6108.2 mg h L-1 or 24625.1 +- 1563.8 mg h L-1, 18-fold higher than quercetin with AUC at 1583.9 +- 583.3 mg h L-1 or 1394.6 +- 868.1 mg h L-1, respectively.	Quercetin	39-48	ribosomal protein L4	Rattus norvegicus	151-154
27775094-8	2016	After oral administration of 100 mg/kg quercetin or 100 mg/kg Q3G in rats, predominantly Q3G was detected in plasma with AUC at 39529.2 +- 6108.2 mg h L-1 or 24625.1 +- 1563.8 mg h L-1, 18-fold higher than quercetin with AUC at 1583.9 +- 583.3 mg h L-1 or 1394.6 +- 868.1 mg h L-1, respectively.	Quercetin	39-48	ribosomal protein L4	Rattus norvegicus	181-184
27513201-10	2016	These results suggest that quercetin may suppress the ER stress-CHOP pathway and dieldrin-induced apoptosis in dopaminergic neurons.	Quercetin	27-36	DNA-damage inducible transcript 3	Mus musculus	64-68
27626494-7	2016	Mechanism study showed quercetin could restore the expression of genes perturbed by Abeta accumulation, such as those involved in cell cycle and DNA replication.	Quercetin	23-32	beta amyloid protein precursor-like	Drosophila melanogaster	84-89
27626494-8	2016	Cyclin B, an important cell cycle protein, was chosen to test whether it participated in the AD ameliorative effects of quercetin.	Quercetin	120-129	Cyclin B	Drosophila melanogaster	0-8
27392941-5	2016	METHODS: We have synthesized folic acid (FA) armed mesoporous silica nanoparticles (MSN-FA-Q) loaded with quercetin and then characterized it by DLS, SEM, TEM and FTIR.	Quercetin	106-115	moesin	Homo sapiens	84-87
27094343-0	2016	Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.	Quercetin	5-14	dystrophin, muscular dystrophy	Mus musculus	75-85
27094343-1	2016	KEY POINT: PGC-1alpha pathway activation has been shown to decrease disease severity and can be driven by quercetin.	Quercetin	106-115	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	11-21
27094343-4	2016	Quercetin supplementation may be a beneficial treatment as part of a cocktail provided continued SIRT1 activity elevation is achieved.	Quercetin	0-9	sirtuin 1	Mus musculus	97-102
27094343-11	2016	To better understand the transient nature of improved respiratory function, we measured PGC-1alpha pathway activity, which is suggested to be up-regulated by quercetin supplementation.	Quercetin	158-167	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	88-98
27295129-8	2016	We also identified 3 drugs, methotrexate, quercetin, and mimosine, which repressed the activated cell cycle genes, ARID5B, STK17B, and CCL2, in HeLa cells with minimal side-effects.	Quercetin	42-51	AT-rich interaction domain 5B	Homo sapiens	115-121
27522262-0	2016	Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells: Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT).	Quercetin	127-136	catechol-O-methyltransferase	Homo sapiens	140-168
27522262-0	2016	Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells: Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT).	Quercetin	127-136	catechol-O-methyltransferase	Homo sapiens	170-174
27522262-7	2016	(2) Inhibition of catechol-O-methyltransferase enzyme by entacapone decreased the antiproliferative effects of fisetin and quercetin.	Quercetin	123-132	catechol-O-methyltransferase	Homo sapiens	18-46
27008429-2	2016	Combining quercetin treatment with delayed transplantation of HUMSCs after local cerebral ischemia significantly (i) improved neurological functional recovery; (ii) reduced proinflammatory cytokines (interleukin(IL)-1beta and IL-6), increased anti-inflammatory cytokines (IL-4, IL-10, and transforming growth factor-beta1), and reduced ED-1 positive areas; (iii) inhibited cell apoptosis (caspase-3 expression); and (iv) improved the survival rate of HUMSCs in the injury site.	Quercetin	10-19	interleukin 1 beta	Rattus norvegicus	200-221
27008429-2	2016	Combining quercetin treatment with delayed transplantation of HUMSCs after local cerebral ischemia significantly (i) improved neurological functional recovery; (ii) reduced proinflammatory cytokines (interleukin(IL)-1beta and IL-6), increased anti-inflammatory cytokines (IL-4, IL-10, and transforming growth factor-beta1), and reduced ED-1 positive areas; (iii) inhibited cell apoptosis (caspase-3 expression); and (iv) improved the survival rate of HUMSCs in the injury site.	Quercetin	10-19	interleukin 6	Rattus norvegicus	226-230
27008429-2	2016	Combining quercetin treatment with delayed transplantation of HUMSCs after local cerebral ischemia significantly (i) improved neurological functional recovery; (ii) reduced proinflammatory cytokines (interleukin(IL)-1beta and IL-6), increased anti-inflammatory cytokines (IL-4, IL-10, and transforming growth factor-beta1), and reduced ED-1 positive areas; (iii) inhibited cell apoptosis (caspase-3 expression); and (iv) improved the survival rate of HUMSCs in the injury site.	Quercetin	10-19	interleukin 4	Rattus norvegicus	272-276
27008429-2	2016	Combining quercetin treatment with delayed transplantation of HUMSCs after local cerebral ischemia significantly (i) improved neurological functional recovery; (ii) reduced proinflammatory cytokines (interleukin(IL)-1beta and IL-6), increased anti-inflammatory cytokines (IL-4, IL-10, and transforming growth factor-beta1), and reduced ED-1 positive areas; (iii) inhibited cell apoptosis (caspase-3 expression); and (iv) improved the survival rate of HUMSCs in the injury site.	Quercetin	10-19	interleukin 10	Rattus norvegicus	278-321
27008429-2	2016	Combining quercetin treatment with delayed transplantation of HUMSCs after local cerebral ischemia significantly (i) improved neurological functional recovery; (ii) reduced proinflammatory cytokines (interleukin(IL)-1beta and IL-6), increased anti-inflammatory cytokines (IL-4, IL-10, and transforming growth factor-beta1), and reduced ED-1 positive areas; (iii) inhibited cell apoptosis (caspase-3 expression); and (iv) improved the survival rate of HUMSCs in the injury site.	Quercetin	10-19	caspase 3	Rattus norvegicus	389-398
27295129-8	2016	We also identified 3 drugs, methotrexate, quercetin, and mimosine, which repressed the activated cell cycle genes, ARID5B, STK17B, and CCL2, in HeLa cells with minimal side-effects.	Quercetin	42-51	serine/threonine kinase 17b	Homo sapiens	123-129
27295129-8	2016	We also identified 3 drugs, methotrexate, quercetin, and mimosine, which repressed the activated cell cycle genes, ARID5B, STK17B, and CCL2, in HeLa cells with minimal side-effects.	Quercetin	42-51	C-C motif chemokine ligand 2	Homo sapiens	135-139
26438716-0	2016	Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities.	Quercetin	39-48	acetylcholinesterase	Rattus norvegicus	86-106
27620077-0	2016	Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt"s lymphoma.	Quercetin	73-82	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-30
27620077-0	2016	Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt"s lymphoma.	Quercetin	73-82	AKT serine/threonine kinase 1	Homo sapiens	51-54
27620077-0	2016	Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt"s lymphoma.	Quercetin	73-82	mechanistic target of rapamycin kinase	Homo sapiens	55-59
27620077-3	2016	In this study we found that quercetin, a bioflavonoid widely distributed in plant kingdom, reduced c-Myc expression and inhibited the PI3K/AKT/mTOR activity in BL, leading to an apoptotic cell death.	Quercetin	28-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	99-104
27620077-3	2016	In this study we found that quercetin, a bioflavonoid widely distributed in plant kingdom, reduced c-Myc expression and inhibited the PI3K/AKT/mTOR activity in BL, leading to an apoptotic cell death.	Quercetin	28-37	AKT serine/threonine kinase 1	Homo sapiens	139-142
27620077-3	2016	In this study we found that quercetin, a bioflavonoid widely distributed in plant kingdom, reduced c-Myc expression and inhibited the PI3K/AKT/mTOR activity in BL, leading to an apoptotic cell death.	Quercetin	28-37	mechanistic target of rapamycin kinase	Homo sapiens	143-147
27620077-5	2016	Besides cell survival, PI3K/AKT/mTOR pathway also regulates autophagy: we found that quercetin induced a complete autophagic flux in BL cells, that contributes to c-Myc reduction in some of these cells.	Quercetin	85-94	AKT serine/threonine kinase 1	Homo sapiens	28-31
27620077-5	2016	Besides cell survival, PI3K/AKT/mTOR pathway also regulates autophagy: we found that quercetin induced a complete autophagic flux in BL cells, that contributes to c-Myc reduction in some of these cells.	Quercetin	85-94	mechanistic target of rapamycin kinase	Homo sapiens	32-36
27620077-5	2016	Besides cell survival, PI3K/AKT/mTOR pathway also regulates autophagy: we found that quercetin induced a complete autophagic flux in BL cells, that contributes to c-Myc reduction in some of these cells.	Quercetin	85-94	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	163-168
27241357-9	2016	Treatment with quercetin significantly suppressed Hsp70 and pAMPK levels and reduced the protective effects of 17-DMAG in HS rats.	Quercetin	15-24	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	50-55
26438716-0	2016	Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities.	Quercetin	39-48	butyrylcholinesterase	Rattus norvegicus	111-132
26438716-3	2016	Quercetin had significantly higher AChE and BChE inhibitory abilities than rutin.	Quercetin	0-9	acetylcholinesterase	Rattus norvegicus	35-39
26438716-3	2016	Quercetin had significantly higher AChE and BChE inhibitory abilities than rutin.	Quercetin	0-9	butyrylcholinesterase	Rattus norvegicus	44-48
28216950-8	2016	Docking studies revealed that thymol binds with AR in similar binding pattern as that of quercetin.	Quercetin	89-98	aldo-keto reductase family 1 member B1	Capra hircus	48-50
27821909-6	2016	Interestingly, quercetin markedly decreased the cadmium-induced LC3-II/beta-actin ratio, reactive oxygen species levels, and malondialdehyde content, and simultaneously increased total antioxidant capacity.	Quercetin	15-24	actin, beta	Mus musculus	71-81
27041117-1	2016	It has been reported that quercetin is an activator of rat vitamin D receptor (rVDR).	Quercetin	26-35	vitamin D receptor	Rattus norvegicus	59-77
27041117-1	2016	It has been reported that quercetin is an activator of rat vitamin D receptor (rVDR).	Quercetin	26-35	vitamin D receptor	Rattus norvegicus	79-83
27041117-3	2016	Furthermore, distinct differences exist in the chemical structures of quercetin and 1alpha,25-dihydroxyvitamin D3, which is a prototypic agonist of VDR.	Quercetin	70-79	vitamin D receptor	Homo sapiens	148-151
30549596-5	2016	When the FRAP assay was applied, the order of increasing of antioxidant activity was quercetin &lt; gallic acid &lt; catechin.	Quercetin	85-94	mechanistic target of rapamycin kinase	Homo sapiens	9-13
27301842-5	2016	The quercetin-supplemented pigs showed decreased serum levels of endotoxin (P&lt;0.05), increased height of jejunum villi (P&lt;0.05), and increased occludin and zonula occudens-1 (ZO-1) mRNA expression in the jejunum (P&lt;0.05).	Quercetin	4-13	occludin	Sus scrofa	149-157
27495232-4	2016	The purpose of this study was to identify alterations in Wnt signaling pathway components involved during prostate cancer progression and to determine the effect of quercetin on TGF-beta-induced EMT in prostate cancer (PC-3) cell line.	Quercetin	165-174	transforming growth factor beta 1	Homo sapiens	178-186
27572418-0	2016	Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase.	Quercetin	0-9	glutamate-cysteine ligase catalytic subunit	Homo sapiens	199-224
27572418-10	2016	Incubation of HAEC with quercetin also led to the appearance of extracellular quercetin-glutathione conjugates, which was paralleled by upregulation of the multidrug resistance protein 1 (MRP1).	Quercetin	24-33	ATP binding cassette subfamily B member 1	Homo sapiens	156-186
27572418-10	2016	Incubation of HAEC with quercetin also led to the appearance of extracellular quercetin-glutathione conjugates, which was paralleled by upregulation of the multidrug resistance protein 1 (MRP1).	Quercetin	24-33	ATP binding cassette subfamily B member 1	Homo sapiens	188-192
27572418-10	2016	Incubation of HAEC with quercetin also led to the appearance of extracellular quercetin-glutathione conjugates, which was paralleled by upregulation of the multidrug resistance protein 1 (MRP1).	Quercetin	78-87	ATP binding cassette subfamily B member 1	Homo sapiens	188-192
27572418-11	2016	Furthermore, quercetin slightly but significantly increased mRNA and protein levels of glutamate-cysteine ligase (GCL) catalytic and modifier subunits.	Quercetin	13-22	glutamate-cysteine ligase catalytic subunit	Homo sapiens	87-112
27572418-11	2016	Furthermore, quercetin slightly but significantly increased mRNA and protein levels of glutamate-cysteine ligase (GCL) catalytic and modifier subunits.	Quercetin	13-22	glutamate-cysteine ligase catalytic subunit	Homo sapiens	114-117
27572418-13	2016	Induction by quercetin of GCL subsequently restores GSH levels, thereby suppressing LPS-induced oxidant production.	Quercetin	13-22	glutamate-cysteine ligase catalytic subunit	Homo sapiens	26-29
27591402-4	2016	Quercetin protected against cholesterol-induced apoptosis of Min6 cells by inhibiting caspase-3 and -9 activation and cytochrome c release.	Quercetin	0-9	caspase 3	Mus musculus	86-102
27591402-6	2016	Quercetin counteracted the cholesterol-induced activation of the NFkappaB pathway in the pancreas and Min6 cells, normalizing the expression of pro-inflammatory cytokines.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	65-73
27591402-7	2016	Quercetin inhibited the cholesterol-induced decrease in sirtuin 1 expression in the pancreas and pancreatic beta-cells.	Quercetin	0-9	sirtuin 1	Mus musculus	56-65
27591402-10	2016	In addition, the inhibition of the NFkappaB pathway is an important mechanism for the protection of quercetin against cytokine mediated cholesterol-induced glycemic control impairment.	Quercetin	100-109	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	35-43
27495232-6	2016	It was observed that quercetin prevented TGF-beta-induced expression of vimentin and N-cadherin and increased the expression of E-cadherin in PC-3 cells, thus preventing TGF-beta-induced EMT.	Quercetin	21-30	vimentin	Homo sapiens	72-80
27495232-6	2016	It was observed that quercetin prevented TGF-beta-induced expression of vimentin and N-cadherin and increased the expression of E-cadherin in PC-3 cells, thus preventing TGF-beta-induced EMT.	Quercetin	21-30	cadherin 2	Homo sapiens	85-95
27495232-6	2016	It was observed that quercetin prevented TGF-beta-induced expression of vimentin and N-cadherin and increased the expression of E-cadherin in PC-3 cells, thus preventing TGF-beta-induced EMT.	Quercetin	21-30	cadherin 1	Homo sapiens	128-138
27495232-6	2016	It was observed that quercetin prevented TGF-beta-induced expression of vimentin and N-cadherin and increased the expression of E-cadherin in PC-3 cells, thus preventing TGF-beta-induced EMT.	Quercetin	21-30	transforming growth factor beta 1	Homo sapiens	170-178
27454768-0	2016	Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	120-123
27454768-0	2016	Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
27454768-4	2016	In this study, we found that quercetin dose-dependently (5-20microM) inhibits lipopolysaccharide (LPS)-induced mRNA and protein expression of E-selectin and ICAM-1 in human aortic endothelial cells (HAEC).	Quercetin	29-38	selectin E	Homo sapiens	142-152
27454768-4	2016	In this study, we found that quercetin dose-dependently (5-20microM) inhibits lipopolysaccharide (LPS)-induced mRNA and protein expression of E-selectin and ICAM-1 in human aortic endothelial cells (HAEC).	Quercetin	29-38	intercellular adhesion molecule 1	Homo sapiens	157-163
27454768-6	2016	Furthermore, quercetin induced activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) and subsequent mRNA and protein expression of the antioxidant enzymes, heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase, quinone 1, and glutamate-cysteine ligase.	Quercetin	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	49-92
27454768-6	2016	Furthermore, quercetin induced activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) and subsequent mRNA and protein expression of the antioxidant enzymes, heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase, quinone 1, and glutamate-cysteine ligase.	Quercetin	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
27454768-6	2016	Furthermore, quercetin induced activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) and subsequent mRNA and protein expression of the antioxidant enzymes, heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase, quinone 1, and glutamate-cysteine ligase.	Quercetin	13-22	heme oxygenase 1	Homo sapiens	171-187
27454768-6	2016	Furthermore, quercetin induced activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) and subsequent mRNA and protein expression of the antioxidant enzymes, heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase, quinone 1, and glutamate-cysteine ligase.	Quercetin	13-22	NAD(P)H quinone dehydrogenase 1	Homo sapiens	196-228
27454768-8	2016	Our results suggest that quercetin suppresses LPS-induced oxidant production and adhesion molecule expression by inducing Nrf2 activation and antioxidant enzyme expression, which is partially mediated by p38; and the inhibitory effect of quercetin on adhesion molecule expression is not due to inhibition of NF-kappaB activation, but instead due to antioxidant-independent effects of HO-1.	Quercetin	25-34	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
27454768-8	2016	Our results suggest that quercetin suppresses LPS-induced oxidant production and adhesion molecule expression by inducing Nrf2 activation and antioxidant enzyme expression, which is partially mediated by p38; and the inhibitory effect of quercetin on adhesion molecule expression is not due to inhibition of NF-kappaB activation, but instead due to antioxidant-independent effects of HO-1.	Quercetin	25-34	mitogen-activated protein kinase 14	Homo sapiens	204-207
26931552-0	2016	3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2.	Quercetin	67-76	nuclear factor, erythroid derived 2, like 2	Mus musculus	153-158
27495232-7	2016	Furthermore, the relative expression of Twist, Snail, and Slug showed that quercetin significantly decreased TGF-beta-induced expression of Twist, Snail, and Slug.	Quercetin	75-84	snail family transcriptional repressor 1	Homo sapiens	47-52
27495232-7	2016	Furthermore, the relative expression of Twist, Snail, and Slug showed that quercetin significantly decreased TGF-beta-induced expression of Twist, Snail, and Slug.	Quercetin	75-84	snail family transcriptional repressor 2	Homo sapiens	58-62
27495232-7	2016	Furthermore, the relative expression of Twist, Snail, and Slug showed that quercetin significantly decreased TGF-beta-induced expression of Twist, Snail, and Slug.	Quercetin	75-84	transforming growth factor beta 1	Homo sapiens	109-117
27495232-7	2016	Furthermore, the relative expression of Twist, Snail, and Slug showed that quercetin significantly decreased TGF-beta-induced expression of Twist, Snail, and Slug.	Quercetin	75-84	snail family transcriptional repressor 1	Homo sapiens	147-152
27495232-7	2016	Furthermore, the relative expression of Twist, Snail, and Slug showed that quercetin significantly decreased TGF-beta-induced expression of Twist, Snail, and Slug.	Quercetin	75-84	snail family transcriptional repressor 2	Homo sapiens	158-162
27495232-6	2016	It was observed that quercetin prevented TGF-beta-induced expression of vimentin and N-cadherin and increased the expression of E-cadherin in PC-3 cells, thus preventing TGF-beta-induced EMT.	Quercetin	21-30	transforming growth factor beta 1	Homo sapiens	41-49
27681719-9	2016	Interestingly, quercetin inhibited EBV viral protein expressions, including EBNA-1 and LMP-2 proteins in tumor tissues from mice injected with EBV(+) human gastric carcinoma.	Quercetin	15-24	EBNA-1	Human gammaherpesvirus 4	76-82
27681719-9	2016	Interestingly, quercetin inhibited EBV viral protein expressions, including EBNA-1 and LMP-2 proteins in tumor tissues from mice injected with EBV(+) human gastric carcinoma.	Quercetin	15-24	BGRF1-BDRF1 protein	Human gammaherpesvirus 4	87-92
27681719-10	2016	Quercetin more effectively induced p53-dependent apoptosis than isoliquiritigenin in EBV(+) human gastric carcinoma, and this induction was correlated with increased expressions of the cleaved forms of caspase-3, -9, and Parp.	Quercetin	0-9	tumor protein p53	Homo sapiens	35-38
27681719-10	2016	Quercetin more effectively induced p53-dependent apoptosis than isoliquiritigenin in EBV(+) human gastric carcinoma, and this induction was correlated with increased expressions of the cleaved forms of caspase-3, -9, and Parp.	Quercetin	0-9	caspase 3	Homo sapiens	202-215
27681719-10	2016	Quercetin more effectively induced p53-dependent apoptosis than isoliquiritigenin in EBV(+) human gastric carcinoma, and this induction was correlated with increased expressions of the cleaved forms of caspase-3, -9, and Parp.	Quercetin	0-9	collagen type XI alpha 2 chain	Homo sapiens	221-225
27681719-11	2016	In EBV(-)human gastric carcinoma (MKN74), both quercetin and isoliquiritigenin induced the expressions of p53, Bax, and Puma and the cleaved forms of caspase-3 and -9 and Parp at similar levels.	Quercetin	47-56	tumor protein p53	Homo sapiens	106-109
27681719-11	2016	In EBV(-)human gastric carcinoma (MKN74), both quercetin and isoliquiritigenin induced the expressions of p53, Bax, and Puma and the cleaved forms of caspase-3 and -9 and Parp at similar levels.	Quercetin	47-56	BCL2 associated X, apoptosis regulator	Homo sapiens	111-114
27681719-11	2016	In EBV(-)human gastric carcinoma (MKN74), both quercetin and isoliquiritigenin induced the expressions of p53, Bax, and Puma and the cleaved forms of caspase-3 and -9 and Parp at similar levels.	Quercetin	47-56	collagen type XI alpha 2 chain	Homo sapiens	171-175
27652191-0	2016	Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs.	Quercetin	33-42	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
27652191-3	2016	In this study, we have evaluated the inhibitory effects of natural bioflavonoids (quercetin and silymarin) on P-gp by using digoxin and quinidine as model P-gp model substrate drugs.	Quercetin	82-91	ATP binding cassette subfamily B member 1	Homo sapiens	110-114
27652191-3	2016	In this study, we have evaluated the inhibitory effects of natural bioflavonoids (quercetin and silymarin) on P-gp by using digoxin and quinidine as model P-gp model substrate drugs.	Quercetin	82-91	ATP binding cassette subfamily B member 1	Homo sapiens	155-159
27652191-11	2016	Caco-2 permeability studies and brain uptake indicate that both quercetin and silymarin can inhibit P-gp mediated efflux of drug into brain.	Quercetin	64-73	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
27652191-12	2016	Our results suggest that both silymarin and quercetin could potentially increase the brain distribution of co-administered drugs that are P-gp substrates.	Quercetin	44-53	ATP binding cassette subfamily B member 1	Homo sapiens	138-142
27450812-0	2016	Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway.	Quercetin	0-9	mitogen-activated protein kinase kinase kinase 5	Mus musculus	84-88
27340105-6	2016	The relative bioavailabilities of quercetin and kaempferol in PLF-PC relative to PLF were 242% and 337%, respectively.	Quercetin	34-43	periostin	Rattus norvegicus	62-65
27450812-0	2016	Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway.	Quercetin	0-9	mitogen-activated protein kinase 10	Mus musculus	89-93
27450812-0	2016	Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway.	Quercetin	0-9	caspase 3	Mus musculus	94-103
27450812-0	2016	Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	121-124
27450812-3	2016	Recent research has demonstrated that quercetin mediates neuroprotective effects associated with the activation of the Akt signaling pathway in the cerebral I/R brain.	Quercetin	38-47	thymoma viral proto-oncogene 1	Mus musculus	119-122
27618095-6	2016	The mixture containing quercetin, curcumin, green tea, cruciferex, and resveratrol (PB) demonstrated significant inhibition of the growth of Fanconi anemia head and neck squamous cell carcinoma and dose-dependent inhibition of cell proliferation, matrix metalloproteinase (MMP)-2 and -9 secretion, cell migration and invasion through Matrigel.	Quercetin	23-32	matrix metallopeptidase 2	Homo sapiens	247-286
27450812-10	2016	Further, western blot analysis revealed that quercetin increased p-Akt expression and decreased p-ASK1, p-JNK3 and cleaved caspase-3 expression after cerebral I/R injury and led to inhibition of neuronal apoptosis.	Quercetin	45-54	thymoma viral proto-oncogene 1	Mus musculus	67-70
27450812-10	2016	Further, western blot analysis revealed that quercetin increased p-Akt expression and decreased p-ASK1, p-JNK3 and cleaved caspase-3 expression after cerebral I/R injury and led to inhibition of neuronal apoptosis.	Quercetin	45-54	mitogen-activated protein kinase kinase kinase 5	Mus musculus	98-102
27450812-10	2016	Further, western blot analysis revealed that quercetin increased p-Akt expression and decreased p-ASK1, p-JNK3 and cleaved caspase-3 expression after cerebral I/R injury and led to inhibition of neuronal apoptosis.	Quercetin	45-54	mitogen-activated protein kinase 10	Mus musculus	106-110
27450812-10	2016	Further, western blot analysis revealed that quercetin increased p-Akt expression and decreased p-ASK1, p-JNK3 and cleaved caspase-3 expression after cerebral I/R injury and led to inhibition of neuronal apoptosis.	Quercetin	45-54	caspase 3	Mus musculus	123-132
27450812-11	2016	Conversely, treatment with LY294002 (a selective inhibitor of Akt1) reversed the effects of quercetin.	Quercetin	92-101	thymoma viral proto-oncogene 1	Mus musculus	62-66
27450812-12	2016	In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt signaling pathway.	Quercetin	62-71	thymoma viral proto-oncogene 1	Mus musculus	155-158
27496247-6	2016	In this study, we investigated the possible effects of flavonoids (quercetin, kaempferol, apigenin, rutin and baicalein) on stimulation of CCK release in vitro using enteroendocrine STC-1 cells.	Quercetin	67-76	cholecystokinin	Homo sapiens	139-142
27610044-16	2016	In addition, quercetin and 2-DG stimulated GSK-3alpha,beta phosphorylation/inactivation, although with different isoform specificity.	Quercetin	13-22	glycogen synthase kinase 3 alpha	Homo sapiens	43-53
27318931-8	2016	As an enhancement to PPTT, we conjugated AuNRs with Quercetin, an inhibitor of HSP70 which displayed anti-cancer effects via apoptosis.	Quercetin	52-61	heat shock protein family A (Hsp70) member 4	Homo sapiens	79-84
27735019-0	2016	Quercetin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in THP-1 macrophages.	Quercetin	0-9	ATP binding cassette subfamily A member 1	Homo sapiens	22-27
27735019-0	2016	Quercetin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in THP-1 macrophages.	Quercetin	0-9	GLI family zinc finger 2	Homo sapiens	91-96
27735019-4	2016	In this study, we try to explore whether quercetin up-regulates LXRa-mediated ABCA1 expression.	Quercetin	41-50	nuclear receptor subfamily 1 group H member 3	Homo sapiens	64-68
27735019-4	2016	In this study, we try to explore whether quercetin up-regulates LXRa-mediated ABCA1 expression.	Quercetin	41-50	ATP binding cassette subfamily A member 1	Homo sapiens	78-83
27735019-8	2016	RESULTS: Real-time PCR and Western blot showed quercetin increased the expression of ABCA1 and LXRalpha at both the mRNA and protein levels in a concentration-dependent and time-dependent manner in THP-1 macrophages.	Quercetin	47-56	ATP binding cassette subfamily A member 1	Homo sapiens	85-90
27735019-8	2016	RESULTS: Real-time PCR and Western blot showed quercetin increased the expression of ABCA1 and LXRalpha at both the mRNA and protein levels in a concentration-dependent and time-dependent manner in THP-1 macrophages.	Quercetin	47-56	nuclear receptor subfamily 1 group H member 3	Homo sapiens	95-103
27735019-8	2016	RESULTS: Real-time PCR and Western blot showed quercetin increased the expression of ABCA1 and LXRalpha at both the mRNA and protein levels in a concentration-dependent and time-dependent manner in THP-1 macrophages.	Quercetin	47-56	GLI family zinc finger 2	Homo sapiens	198-203
27521217-0	2016	Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl.	Quercetin	36-45	microRNA let-7c	Gallus gallus	26-32
27521217-0	2016	Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl.	Quercetin	36-45	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	Gallus gallus	102-107
27521217-5	2016	miR let-7c was among the top up-regulated candidates after quercetin treatment, as measured by qRT-PCR and confirmed in two established and one primary PDA cell lines.	Quercetin	59-68	microRNA let-7c	Gallus gallus	0-10
27521217-8	2016	Let-7c induced Numbl mRNA and protein expression but inhibited Notch just like quercetin.	Quercetin	79-88	microRNA let-7c	Gallus gallus	0-6
27521217-13	2016	These findings show that quercetin-induced let-7c decreases tumor growth by posttranscriptional activation of Numbl and indirect inhibition of Notch.	Quercetin	25-34	microRNA let-7c	Gallus gallus	43-49
27521217-13	2016	These findings show that quercetin-induced let-7c decreases tumor growth by posttranscriptional activation of Numbl and indirect inhibition of Notch.	Quercetin	25-34	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	Gallus gallus	110-115
27498772-0	2016	Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCepsilon-dependent activation of TRPV1.	Quercetin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	146-151
27498772-10	2016	RESULTS: Pretreatment with quercetin (3, 10, 30 mumol/L) dose-dependently inhibited excessive histamine release from paclitaxel-stimulated RBL-2H3 cells in vitro, and quercetin administration significantly suppressed the high plasma histamine levels in paclitaxel-treated rats.	Quercetin	27-36	RB transcriptional corepressor like 2	Rattus norvegicus	139-144
27498772-12	2016	Furthermore, quercetin administration dose-dependently suppressed the increased expression levels of PKCepsilon and TRPV1 in the spinal cords and DRGs of paclitaxel-treated rats and mice.	Quercetin	13-22	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	116-121
27026422-2	2016	We hypothesised that lactose-intolerant people (who do not express lactase) will retain intact quercetin glucosides that can inhibit glucose uptake via the glucose transporter SGLT1, whereas lactose-tolerant people (who do express lactase) will hydrolyse quercetin glucosides to free quercetin that does not inhibit glucose uptake.	Quercetin	95-104	solute carrier family 5 member 1	Homo sapiens	176-181
27735019-11	2016	Meanwhile, the expression of ABCA1 was also recovered after incubated with the combination of LXRa siRNA and quercetin compared with quercetin alone.	Quercetin	109-118	ATP binding cassette subfamily A member 1	Homo sapiens	29-34
27735019-11	2016	Meanwhile, the expression of ABCA1 was also recovered after incubated with the combination of LXRa siRNA and quercetin compared with quercetin alone.	Quercetin	133-142	ATP binding cassette subfamily A member 1	Homo sapiens	29-34
27735019-11	2016	Meanwhile, the expression of ABCA1 was also recovered after incubated with the combination of LXRa siRNA and quercetin compared with quercetin alone.	Quercetin	133-142	nuclear receptor subfamily 1 group H member 3	Homo sapiens	94-98
27735019-12	2016	CONCLUSIONS: Quercetin could increase ABCA1 expression and cholesterol efflux through LXRalpha pathway to eventually promote RCT in the THP-1 macrophage.	Quercetin	13-22	ATP binding cassette subfamily A member 1	Homo sapiens	38-43
27735019-12	2016	CONCLUSIONS: Quercetin could increase ABCA1 expression and cholesterol efflux through LXRalpha pathway to eventually promote RCT in the THP-1 macrophage.	Quercetin	13-22	nuclear receptor subfamily 1 group H member 3	Homo sapiens	86-94
27735019-12	2016	CONCLUSIONS: Quercetin could increase ABCA1 expression and cholesterol efflux through LXRalpha pathway to eventually promote RCT in the THP-1 macrophage.	Quercetin	13-22	GLI family zinc finger 2	Homo sapiens	136-141
27496247-7	2016	In comparison with the control, quercetin, kaempferol and apigenin resulted in a significant increase in CCK secretion with quercetin showing the highest activity.	Quercetin	32-41	cholecystokinin	Homo sapiens	105-108
27496247-7	2016	In comparison with the control, quercetin, kaempferol and apigenin resulted in a significant increase in CCK secretion with quercetin showing the highest activity.	Quercetin	124-133	cholecystokinin	Homo sapiens	105-108
27496247-9	2016	To our knowledge, this is the first report to study the stimulation of CCK peptide hormone secretion from STC-1 cells by quercetin and kaempferol, rutin, apigenin and baicalein.	Quercetin	121-130	cholecystokinin	Homo sapiens	71-74
27477310-0	2016	Quercetin sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through JNK-mediated cFLIP turnover.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	48-53
27477310-0	2016	Quercetin sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through JNK-mediated cFLIP turnover.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	80-83
27477310-0	2016	Quercetin sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through JNK-mediated cFLIP turnover.	Quercetin	0-9	CASP8 and FADD like apoptosis regulator	Homo sapiens	93-98
27477310-3	2016	In this study, we tested the hypothesis that quercetin, a flavonoid, induces apoptosis in TRAIL-resistant pancreatic cancer cells.	Quercetin	45-54	TNF superfamily member 10	Homo sapiens	90-95
27477310-4	2016	Although quercetin alone had no significant cytotoxic effect, when combined with TRAIL, it promoted TRAIL-induced apoptosis that required mitochondrial outer membrane permeabilization.	Quercetin	9-18	TNF superfamily member 10	Homo sapiens	100-105
27477310-5	2016	A BH3-only protein BID knockdown dramatically attenuated TRAIL/quercetin-induced apoptosis.	Quercetin	63-72	TNF superfamily member 10	Homo sapiens	57-62
27477310-6	2016	The expression levels of cellular FLICE-like inhibitory protein (cFLIP) decreased in a dose-dependent manner in the presence of quercetin, and overexpression of cFLIP was able to robustly rescue pancreatic cancer cells from TRAIL/quercetin-induced apoptosis.	Quercetin	128-137	CASP8 and FADD like apoptosis regulator	Homo sapiens	25-63
27477310-6	2016	The expression levels of cellular FLICE-like inhibitory protein (cFLIP) decreased in a dose-dependent manner in the presence of quercetin, and overexpression of cFLIP was able to robustly rescue pancreatic cancer cells from TRAIL/quercetin-induced apoptosis.	Quercetin	128-137	CASP8 and FADD like apoptosis regulator	Homo sapiens	65-70
27477310-6	2016	The expression levels of cellular FLICE-like inhibitory protein (cFLIP) decreased in a dose-dependent manner in the presence of quercetin, and overexpression of cFLIP was able to robustly rescue pancreatic cancer cells from TRAIL/quercetin-induced apoptosis.	Quercetin	128-137	TNF superfamily member 10	Homo sapiens	224-229
27477310-6	2016	The expression levels of cellular FLICE-like inhibitory protein (cFLIP) decreased in a dose-dependent manner in the presence of quercetin, and overexpression of cFLIP was able to robustly rescue pancreatic cancer cells from TRAIL/quercetin-induced apoptosis.	Quercetin	230-239	CASP8 and FADD like apoptosis regulator	Homo sapiens	25-63
27477310-6	2016	The expression levels of cellular FLICE-like inhibitory protein (cFLIP) decreased in a dose-dependent manner in the presence of quercetin, and overexpression of cFLIP was able to robustly rescue pancreatic cancer cells from TRAIL/quercetin-induced apoptosis.	Quercetin	230-239	CASP8 and FADD like apoptosis regulator	Homo sapiens	65-70
27477310-6	2016	The expression levels of cellular FLICE-like inhibitory protein (cFLIP) decreased in a dose-dependent manner in the presence of quercetin, and overexpression of cFLIP was able to robustly rescue pancreatic cancer cells from TRAIL/quercetin-induced apoptosis.	Quercetin	230-239	CASP8 and FADD like apoptosis regulator	Homo sapiens	161-166
27477310-7	2016	Additionally, quercetin activated c-Jun N-terminal kinase (JNK) in a dose-dependent manner, which in turn induced the proteasomal degradation of cFLIP, and JNK activation also sensitized pancreatic cancer cells to TRAIL-induced apoptosis.	Quercetin	14-23	mitogen-activated protein kinase 8	Homo sapiens	34-57
27477310-7	2016	Additionally, quercetin activated c-Jun N-terminal kinase (JNK) in a dose-dependent manner, which in turn induced the proteasomal degradation of cFLIP, and JNK activation also sensitized pancreatic cancer cells to TRAIL-induced apoptosis.	Quercetin	14-23	mitogen-activated protein kinase 8	Homo sapiens	59-62
27477310-7	2016	Additionally, quercetin activated c-Jun N-terminal kinase (JNK) in a dose-dependent manner, which in turn induced the proteasomal degradation of cFLIP, and JNK activation also sensitized pancreatic cancer cells to TRAIL-induced apoptosis.	Quercetin	14-23	CASP8 and FADD like apoptosis regulator	Homo sapiens	145-150
27477310-7	2016	Additionally, quercetin activated c-Jun N-terminal kinase (JNK) in a dose-dependent manner, which in turn induced the proteasomal degradation of cFLIP, and JNK activation also sensitized pancreatic cancer cells to TRAIL-induced apoptosis.	Quercetin	14-23	mitogen-activated protein kinase 8	Homo sapiens	156-159
27477310-7	2016	Additionally, quercetin activated c-Jun N-terminal kinase (JNK) in a dose-dependent manner, which in turn induced the proteasomal degradation of cFLIP, and JNK activation also sensitized pancreatic cancer cells to TRAIL-induced apoptosis.	Quercetin	14-23	TNF superfamily member 10	Homo sapiens	214-219
27477310-8	2016	Thus, our results suggest that quercetin induces TRAIL-induced apoptosis via JNK activation-mediated cFLIP turnover.	Quercetin	31-40	TNF superfamily member 10	Homo sapiens	49-54
27477310-8	2016	Thus, our results suggest that quercetin induces TRAIL-induced apoptosis via JNK activation-mediated cFLIP turnover.	Quercetin	31-40	mitogen-activated protein kinase 8	Homo sapiens	77-80
27477310-8	2016	Thus, our results suggest that quercetin induces TRAIL-induced apoptosis via JNK activation-mediated cFLIP turnover.	Quercetin	31-40	CASP8 and FADD like apoptosis regulator	Homo sapiens	101-106
27114256-0	2016	Quercetin stabilizes apolipoprotein E and reduces brain Abeta levels in amyloid model mice.	Quercetin	0-9	apolipoprotein E	Mus musculus	21-37
27114256-0	2016	Quercetin stabilizes apolipoprotein E and reduces brain Abeta levels in amyloid model mice.	Quercetin	0-9	amyloid beta (A4) precursor protein	Mus musculus	56-61
27114256-10	2016	We report here that quercetin can significantly increase apoE levels by inhibiting apoE degradation in immortalized astrocytes.	Quercetin	20-29	apolipoprotein E	Mus musculus	57-61
27114256-10	2016	We report here that quercetin can significantly increase apoE levels by inhibiting apoE degradation in immortalized astrocytes.	Quercetin	20-29	apolipoprotein E	Mus musculus	83-87
27114256-11	2016	Importantly, we show that oral administration of quercetin significantly increased brain apoE and reduced insoluble Abeta levels in the cortex of 5xFAD amyloid model mice.	Quercetin	49-58	apolipoprotein E	Mus musculus	89-93
27339657-7	2016	Botanicals such as quercetin and honokiol (but not cyanidin-3-O-glucoside, 3CG) were effective in inhibiting LPS-induced nitric oxide (NO) production and phosphorylation of cPLA2.	Quercetin	19-28	phospholipase A2 group IVA	Homo sapiens	173-178
27114256-11	2016	Importantly, we show that oral administration of quercetin significantly increased brain apoE and reduced insoluble Abeta levels in the cortex of 5xFAD amyloid model mice.	Quercetin	49-58	amyloid beta (A4) precursor protein	Mus musculus	116-121
27114256-12	2016	Our results demonstrate that quercetin increases apoE levels through a novel mechanism and can be explored as a novel class of drug for AD therapy.	Quercetin	29-38	apolipoprotein E	Mus musculus	49-53
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	myeloperoxidase	Mus musculus	20-35
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	myeloperoxidase	Mus musculus	37-40
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	O-GlcNAcase	Mus musculus	46-78
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	O-GlcNAcase	Mus musculus	80-83
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	136-152
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	154-159
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	cytochrome b-245, beta polypeptide	Mus musculus	165-173
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	myogenic differentiation 1	Mus musculus	249-279
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	myogenic differentiation 1	Mus musculus	281-285
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	357-361
27583449-4	2016	Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle.	Quercetin	0-9	heme oxygenase 1	Mus musculus	366-370
27583449-5	2016	Beyond inhibiting those peripheral effects, quercetin also inhibited spinal cord cytokine production, oxidative stress and glial cells activation (glial fibrillary acidic protein [GFAP] and ionized calcium-binding adapter molecule 1 [Iba-1] mRNA expression).	Quercetin	44-53	allograft inflammatory factor 1	Mus musculus	190-232
27583449-5	2016	Beyond inhibiting those peripheral effects, quercetin also inhibited spinal cord cytokine production, oxidative stress and glial cells activation (glial fibrillary acidic protein [GFAP] and ionized calcium-binding adapter molecule 1 [Iba-1] mRNA expression).	Quercetin	44-53	allograft inflammatory factor 1	Mus musculus	234-239
27546480-4	2016	In both cell types, quercetin significantly decreased i) the viral genome replication; ii) the production of infectious HCV particles and iii) the specific infectivity of the newly produced viral particles (by 85% and 92%, Huh7.5 and PHH respectively).	Quercetin	20-29	MIR7-3 host gene	Homo sapiens	223-227
27545129-0	2016	[Effects and related mechanism of quercetin on thrombin-induced proliferation and migration of rat vascular smooth muscle cells].	Quercetin	34-43	coagulation factor II	Rattus norvegicus	47-55
27545129-1	2016	OBJECTIVE: To investigate the effects and related mechanism of quercetin on thrombin-induced proliferation and migration of rat vascular smooth muscle cells(VSMCs).	Quercetin	63-72	coagulation factor II	Rattus norvegicus	76-84
27545129-5	2016	RESULTS: (1) According to the CCK-8 results, optical density value was significantly higher in thrombin group than that of control group(2.59+-0.16 vs. 1.97+-0.18, P&lt;0.01), which could be significantly attenuated by pretreatment with quercetin(2.13+-0.19, P&lt;0.01), and there was no significant difference between quercetin group and control group(P&gt;0.05).	Quercetin	237-246	coagulation factor II	Rattus norvegicus	95-103
27545129-5	2016	RESULTS: (1) According to the CCK-8 results, optical density value was significantly higher in thrombin group than that of control group(2.59+-0.16 vs. 1.97+-0.18, P&lt;0.01), which could be significantly attenuated by pretreatment with quercetin(2.13+-0.19, P&lt;0.01), and there was no significant difference between quercetin group and control group(P&gt;0.05).	Quercetin	319-328	coagulation factor II	Rattus norvegicus	95-103
27545129-6	2016	(2) The transwell results showed that the migrated VSMCs were significantly higher in thrombin group than in control group (1 337+-162 vs. 99+-26, P&lt;0.01), which could be significantly reduced by pretreatment with quercetin (926+-111, P&lt;0.05), but still significantly higher than control group (P&lt;0.01).	Quercetin	217-226	coagulation factor II	Rattus norvegicus	86-94
27545129-7	2016	(3) The protein expressions of phospho-extracellular signal regulated kinase 1/2 and phosphor-p38 were significantly upregulated in thrombin group compared to control group (both P&lt;0.05), which could be significantly downregulated by pretreatment with quercetin (P&lt;0.05).	Quercetin	255-264	mitogen activated protein kinase 3	Rattus norvegicus	39-80
27545129-7	2016	(3) The protein expressions of phospho-extracellular signal regulated kinase 1/2 and phosphor-p38 were significantly upregulated in thrombin group compared to control group (both P&lt;0.05), which could be significantly downregulated by pretreatment with quercetin (P&lt;0.05).	Quercetin	255-264	mitogen activated protein kinase 14	Rattus norvegicus	94-97
27545129-7	2016	(3) The protein expressions of phospho-extracellular signal regulated kinase 1/2 and phosphor-p38 were significantly upregulated in thrombin group compared to control group (both P&lt;0.05), which could be significantly downregulated by pretreatment with quercetin (P&lt;0.05).	Quercetin	255-264	coagulation factor II	Rattus norvegicus	132-140
27545129-8	2016	CONCLUSION: Quercetin can effectively attenuate thrombin-induced vascular smooth muscle cells proliferation and migration, possibly through inhibiting the phosphorylation of extracellular signal regulated kinase 1/2 and p38 pathway.	Quercetin	12-21	coagulation factor II	Rattus norvegicus	48-56
27545129-8	2016	CONCLUSION: Quercetin can effectively attenuate thrombin-induced vascular smooth muscle cells proliferation and migration, possibly through inhibiting the phosphorylation of extracellular signal regulated kinase 1/2 and p38 pathway.	Quercetin	12-21	mitogen activated protein kinase 3	Rattus norvegicus	174-215
27545129-8	2016	CONCLUSION: Quercetin can effectively attenuate thrombin-induced vascular smooth muscle cells proliferation and migration, possibly through inhibiting the phosphorylation of extracellular signal regulated kinase 1/2 and p38 pathway.	Quercetin	12-21	mitogen activated protein kinase 14	Rattus norvegicus	220-223
27546480-6	2016	Interestingly, the HCV-induced up-regulation of diacylglycerol acyltransferase (DGAT) and the typical localization of the HCV core protein to the surface of lipid droplets, known to be mediated by DGAT, were both prevented by quercetin.	Quercetin	226-235	diacylglycerol O-acyltransferase 1	Homo sapiens	48-78
27546480-6	2016	Interestingly, the HCV-induced up-regulation of diacylglycerol acyltransferase (DGAT) and the typical localization of the HCV core protein to the surface of lipid droplets, known to be mediated by DGAT, were both prevented by quercetin.	Quercetin	226-235	diacylglycerol O-acyltransferase 1	Homo sapiens	197-201
27494022-0	2016	PI-103 and Quercetin Attenuate PI3K-AKT Signaling Pathway in T- Cell Lymphoma Exposed to Hydrogen Peroxide.	Quercetin	11-20	AKT serine/threonine kinase 1	Homo sapiens	36-39
27648146-0	2016	Quercetin induces mitochondrial biogenesis in experimental traumatic brain injury via the PGC-1alpha signaling pathway.	Quercetin	0-9	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	90-100
27648146-5	2016	Quercetin treatment upregulated the expression of PGC-1alpha and restored the level of cytochrome c, malondialdehyde (MDA) and superoxide dismutase (SOD).	Quercetin	0-9	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	50-60
27648146-6	2016	These results demonstrate that quercetin improves mitochondrial function in mice by improving the level of PGC-1alpha following TBI.	Quercetin	31-40	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	107-117
27132804-0	2016	Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcumin.	Quercetin	169-178	androgen receptor	Homo sapiens	127-144
27132804-2	2016	Some dietary phytocompounds like quercetin (Q) and curcumin (C) with reported DNMT-inhibitory activity were tested for their ability to re-express the AR in AR-negative CaP cell lines PC3 and DU145.	Quercetin	33-42	androgen receptor	Homo sapiens	151-153
27514524-2	2016	Previously, we reported that Quercetin in combination with Cisplatin inhibits cell proliferation and activates caspase-9 and -3 enzymes in different malignant mesothelioma cell lines.	Quercetin	29-38	caspase 9	Homo sapiens	111-127
27514524-7	2016	Moreover, while p38 and JNK phosphorylations were increased, ERK phosphorylations were decreased after using Quercetin + Cisplatin.	Quercetin	109-118	mitogen-activated protein kinase 1	Homo sapiens	61-64
27494022-11	2016	Both PI-103 &amp; quercetin suppressed the enhanced level of ROS and significantly down-regulated phosphorylation of AKT, PDK1, BAD and level of TNFR1 as well as increased the level of PTEN in H2O2 induced lymphoma cells.	Quercetin	18-27	AKT serine/threonine kinase 1	Homo sapiens	117-120
27494022-11	2016	Both PI-103 &amp; quercetin suppressed the enhanced level of ROS and significantly down-regulated phosphorylation of AKT, PDK1, BAD and level of TNFR1 as well as increased the level of PTEN in H2O2 induced lymphoma cells.	Quercetin	18-27	pyruvate dehydrogenase kinase 1	Homo sapiens	122-126
29029404-2	2017	In this context, we have reported that Quercetin (QC) induces cell death selectively in hESCs via p53 mitochondrial localization.	Quercetin	39-48	tumor protein p53	Homo sapiens	98-101
27494022-8	2016	Further, regulation of PI3K-AKT pathway by quercetin as well as PI-103, an inhibitor of PI3K was analyzed.	Quercetin	43-52	AKT serine/threonine kinase 1	Homo sapiens	28-31
27494022-11	2016	Both PI-103 &amp; quercetin suppressed the enhanced level of ROS and significantly down-regulated phosphorylation of AKT, PDK1, BAD and level of TNFR1 as well as increased the level of PTEN in H2O2 induced lymphoma cells.	Quercetin	18-27	TNF receptor superfamily member 1A	Homo sapiens	145-150
27470402-0	2016	The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression.	Quercetin	14-23	Janus kinase 2	Homo sapiens	128-132
27494022-11	2016	Both PI-103 &amp; quercetin suppressed the enhanced level of ROS and significantly down-regulated phosphorylation of AKT, PDK1, BAD and level of TNFR1 as well as increased the level of PTEN in H2O2 induced lymphoma cells.	Quercetin	18-27	phosphatase and tensin homolog	Homo sapiens	185-189
27494022-12	2016	The overall result suggests that quercetin and PI3K inhibitor PI-103 attenuate PI3K-AKT pathway in a similar mechanism.	Quercetin	33-42	AKT serine/threonine kinase 1	Homo sapiens	84-87
27470402-13	2016	Notably, administration with quercetin nanoparticles displayed similar role with JAK2 suppression, which could inhibit cervical cancer cells proliferation, invasion and migration.	Quercetin	29-38	Janus kinase 2	Homo sapiens	81-85
27525872-0	2016	Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression.	Quercetin	21-30	intercellular adhesion molecule 1	Rattus norvegicus	93-99
27393003-8	2016	Quercetin treatment induced the myocardial expression of Prx-3 but not Prx-5 both in control and STZ rats.	Quercetin	0-9	peroxiredoxin 3	Rattus norvegicus	57-62
27393003-9	2016	Prx-3 induction by quercetin prevented diabetes induced oxidative stress as confirmed by decrease in expression of markers such as 4-HNE and mitochondrial uncoupling protein, UCP-3.	Quercetin	19-28	peroxiredoxin 3	Rattus norvegicus	0-5
27393003-9	2016	Prx-3 induction by quercetin prevented diabetes induced oxidative stress as confirmed by decrease in expression of markers such as 4-HNE and mitochondrial uncoupling protein, UCP-3.	Quercetin	19-28	uncoupling protein 3	Rattus norvegicus	175-180
27278820-0	2016	Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	142-145
27278820-4	2016	Moreover, quercetin induced cell apoptosis in a mitochondrial-dependent manner, as shown by the reduction in mitochondrial membrane potential, the activation of caspase-3 and -9, and the downregulation of Bcl-2, as well as the upregulation of Bax and cytochrome c (Cyt-c).	Quercetin	10-19	caspase 3	Homo sapiens	161-177
27278820-4	2016	Moreover, quercetin induced cell apoptosis in a mitochondrial-dependent manner, as shown by the reduction in mitochondrial membrane potential, the activation of caspase-3 and -9, and the downregulation of Bcl-2, as well as the upregulation of Bax and cytochrome c (Cyt-c).	Quercetin	10-19	BCL2 apoptosis regulator	Homo sapiens	205-210
27278820-4	2016	Moreover, quercetin induced cell apoptosis in a mitochondrial-dependent manner, as shown by the reduction in mitochondrial membrane potential, the activation of caspase-3 and -9, and the downregulation of Bcl-2, as well as the upregulation of Bax and cytochrome c (Cyt-c).	Quercetin	10-19	BCL2 associated X, apoptosis regulator	Homo sapiens	243-246
27278820-4	2016	Moreover, quercetin induced cell apoptosis in a mitochondrial-dependent manner, as shown by the reduction in mitochondrial membrane potential, the activation of caspase-3 and -9, and the downregulation of Bcl-2, as well as the upregulation of Bax and cytochrome c (Cyt-c).	Quercetin	10-19	cytochrome c, somatic	Homo sapiens	251-263
27278820-4	2016	Moreover, quercetin induced cell apoptosis in a mitochondrial-dependent manner, as shown by the reduction in mitochondrial membrane potential, the activation of caspase-3 and -9, and the downregulation of Bcl-2, as well as the upregulation of Bax and cytochrome c (Cyt-c).	Quercetin	10-19	cytochrome c, somatic	Homo sapiens	265-270
27278820-5	2016	Additionally, a marked decrease in Akt phosphorylation levels was observed following treatment with quercetin, whereas pre-treatment with fumonisin B1 (FB1, Akt activator) significantly attenuated the inhibitory effects of quercetin on cell growth and its promoting effects on mitochondrial-dependent apoptosis.	Quercetin	100-109	AKT serine/threonine kinase 1	Homo sapiens	35-38
27278820-5	2016	Additionally, a marked decrease in Akt phosphorylation levels was observed following treatment with quercetin, whereas pre-treatment with fumonisin B1 (FB1, Akt activator) significantly attenuated the inhibitory effects of quercetin on cell growth and its promoting effects on mitochondrial-dependent apoptosis.	Quercetin	223-232	AKT serine/threonine kinase 1	Homo sapiens	157-160
27278820-6	2016	Notably, FB1 enhanced the expression of Bcl-2, which was inhibited by quercetin, and prevented the decrease in mitochondrial membrane potential induced by quercetin.	Quercetin	70-79	BCL2 apoptosis regulator	Homo sapiens	40-45
27278820-7	2016	However, the increase in the levels of caspases, Bax and Cyt-c induced by quercetin was also attenuated by the addition of FB1 to the GCSCs.	Quercetin	74-83	caspase 9	Homo sapiens	39-47
27278820-7	2016	However, the increase in the levels of caspases, Bax and Cyt-c induced by quercetin was also attenuated by the addition of FB1 to the GCSCs.	Quercetin	74-83	BCL2 associated X, apoptosis regulator	Homo sapiens	49-52
27278820-7	2016	However, the increase in the levels of caspases, Bax and Cyt-c induced by quercetin was also attenuated by the addition of FB1 to the GCSCs.	Quercetin	74-83	cytochrome c, somatic	Homo sapiens	57-62
27278820-8	2016	Therefore, our results demonstrate that quercetin triggers mitochondrial apoptotic-dependent growth inhibition via the blockade of phosphoinositide 3-kinase (PI3K)-Akt signaling in GCSCs, indicating a potential target for the treatment of gastric cancer.	Quercetin	40-49	AKT serine/threonine kinase 1	Homo sapiens	164-167
27367273-6	2016	In this cell line, both tBHQ and quercetin (Nrf2 agonists), but not rutin, were able to induce, in a dose-dependent fashion, the luciferase response.	Quercetin	33-42	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
27244466-7	2016	Quercetin (100 mg/kg), an inhibitor of heat shock protein 70 (HSP70), was injected into the peritoneum 2 hours before SAH induction.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	39-60
27244466-7	2016	Quercetin (100 mg/kg), an inhibitor of heat shock protein 70 (HSP70), was injected into the peritoneum 2 hours before SAH induction.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	62-67
26754474-0	2016	Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury.	Quercetin	0-9	NLR family, pyrin domain containing 3	Rattus norvegicus	21-26
26754474-7	2016	Quercetin administration significantly decreased reactive oxygen species production, inhibited NLRP3 inflammasome activation and reduced inflammatory cytokine levels.	Quercetin	0-9	NLR family, pyrin domain containing 3	Rattus norvegicus	95-100
26754474-9	2016	CONCLUSION: Quercetin can attenuate tissue damage and improve neurological function recovery, and the mechanism may be related to the inhibition of NLRP3 inflammasome activation.	Quercetin	12-21	NLR family, pyrin domain containing 3	Rattus norvegicus	148-153
27470932-9	2016	Pretreatment with quercetin (20 muM; 24 h before trauma plasma addition) significantly attenuated trauma-induced viability decreases, TNF-alpha increases, ROS overproduction and [Ca(2+)]i overload in H9c2 cells.	Quercetin	18-27	tumor necrosis factor	Rattus norvegicus	134-143
27470932-10	2016	In conclusion, quercetin may reverse posttraumatic cardiac dysfunction by reducing cardiomyocyte apoptosis through the suppression of TNF-alpha increases, ROS overproduction and Ca(2+) overload in cardiomyocytes, representing a potential preventive approach for the treatment of secondary cardiac injury after mechanical trauma.	Quercetin	15-24	tumor necrosis factor	Rattus norvegicus	134-143
26829336-12	2016	Findings for quercetin with regard to UGT2B7 and SULT2A1 and for kaempferol with regard to SULT1E1 and SULT2A1 suggested a mechanism based inhibition.	Quercetin	13-22	sulfotransferase family 2A member 1	Homo sapiens	49-56
26660542-3	2016	Quercetin delivered from hydrogel show a time and CD44 dependent interaction with both cell lines with significant anti-inflammatory effects.	Quercetin	0-9	CD44 molecule (Indian blood group)	Homo sapiens	50-54
27174198-0	2016	Quercetin blocks t-AUCB-induced autophagy by Hsp27 and Atg7 inhibition in glioblastoma cells in vitro.	Quercetin	0-9	heat shock protein family B (small) member 1	Homo sapiens	45-50
27174198-0	2016	Quercetin blocks t-AUCB-induced autophagy by Hsp27 and Atg7 inhibition in glioblastoma cells in vitro.	Quercetin	0-9	autophagy related 7	Homo sapiens	55-59
27174198-5	2016	Hsp27 inhibitor quercetin suppresses Atg7 expression and strengthens t-AUCB-induced cell death by autophagy blockage.	Quercetin	16-25	heat shock protein family B (small) member 1	Homo sapiens	0-5
27174198-5	2016	Hsp27 inhibitor quercetin suppresses Atg7 expression and strengthens t-AUCB-induced cell death by autophagy blockage.	Quercetin	16-25	autophagy related 7	Homo sapiens	37-41
27373212-4	2016	Quercetin treatment inhibited MCT1 expression but did not affect PFKFB3 expression.	Quercetin	0-9	solute carrier family 16 member 1	Homo sapiens	30-34
27373212-8	2016	Thus, we concluded that the targeting of MCT1 and PFKFB3 regulated cell proliferation and apoptosis in BC cells by altering the tumor microenvironment, and quercetin exhibited a potential antitumor effect by targeting MCT1.	Quercetin	156-165	solute carrier family 16 member 1	Homo sapiens	218-222
27525872-0	2016	Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression.	Quercetin	21-30	C-X-C motif chemokine ligand 2	Rattus norvegicus	104-109
27525872-9	2016	The quercetin groups presented lower ICAM-1 and MIP-2 expression than the control model group, with the lowest expression observed in the high-dose group (P &lt; 0.05).	Quercetin	4-13	intercellular adhesion molecule 1	Rattus norvegicus	37-43
27525872-9	2016	The quercetin groups presented lower ICAM-1 and MIP-2 expression than the control model group, with the lowest expression observed in the high-dose group (P &lt; 0.05).	Quercetin	4-13	C-X-C motif chemokine ligand 2	Rattus norvegicus	48-53
27525872-10	2016	Quercetin may protect against ALI in rats with sepsis by inhibiting ICAM-1 and MIP-2 expression.	Quercetin	0-9	intercellular adhesion molecule 1	Rattus norvegicus	68-74
27525872-10	2016	Quercetin may protect against ALI in rats with sepsis by inhibiting ICAM-1 and MIP-2 expression.	Quercetin	0-9	C-X-C motif chemokine ligand 2	Rattus norvegicus	79-84
27415000-11	2016	Importantly, stimulated expression of IL-1beta and IL-8 in HaCaT-TNF-alpha were blocked by Quercetin, a flavanol shown to possess anti-TNF-alpha activities.	Quercetin	91-100	interleukin 1 beta	Homo sapiens	38-46
27216424-7	2016	It has been found that quercetin and rutin were the highly desirable flavonoids for the inhibition of P-gp transport function and they significantly reduced resistance in cytotoxicity assays to paclitaxel in P-gp overexpressing MDR cell lines.	Quercetin	23-32	ATP binding cassette subfamily B member 1	Homo sapiens	102-106
27216424-7	2016	It has been found that quercetin and rutin were the highly desirable flavonoids for the inhibition of P-gp transport function and they significantly reduced resistance in cytotoxicity assays to paclitaxel in P-gp overexpressing MDR cell lines.	Quercetin	23-32	ATP binding cassette subfamily B member 1	Homo sapiens	208-212
27421015-0	2016	Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-kappaB pathway.	Quercetin	0-9	toll like receptor 2	Homo sapiens	112-116
27421015-7	2016	Quercetin suppressed the secretion of tumor necrosis factor-a, interleukin (IL)-1b, and IL-6 in LPS-stimulated human PBMCs.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	63-82
27421015-7	2016	Quercetin suppressed the secretion of tumor necrosis factor-a, interleukin (IL)-1b, and IL-6 in LPS-stimulated human PBMCs.	Quercetin	0-9	interleukin 6	Homo sapiens	88-92
27421015-8	2016	Moreover, quercetin reduced the LPS-induced increase in the expression of TLR2 mRNA and decreased the NF-kB concentration in LPS-stimulated human PBMCs.	Quercetin	10-19	toll like receptor 2	Homo sapiens	74-78
27421015-9	2016	The data indicates that quercetin plays an important role in LPS-induced inflammation in human PBMCs via suppression of the TLR2-NF-kB pathway.	Quercetin	24-33	toll like receptor 2	Homo sapiens	124-128
27329589-5	2016	Quercetin inhibited proliferation of MM cells (RPMI8226, ARP-1, and MM.1R) by inducing cell cycle arrest in the G2/M phase and apoptosis.	Quercetin	0-9	actin related protein 1A	Homo sapiens	57-62
27329589-6	2016	Western blot showed that quercetin downregulated c-myc expression and upregulated p21 expression.	Quercetin	25-34	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	49-54
27329589-6	2016	Western blot showed that quercetin downregulated c-myc expression and upregulated p21 expression.	Quercetin	25-34	H3 histone pseudogene 16	Homo sapiens	82-85
27329589-7	2016	Quercetin also activated caspase-3, caspase-9, and poly(ADP-ribose)polymerase 1.	Quercetin	0-9	caspase 3	Homo sapiens	25-34
27329589-7	2016	Quercetin also activated caspase-3, caspase-9, and poly(ADP-ribose)polymerase 1.	Quercetin	0-9	caspase 9	Homo sapiens	36-45
27329589-7	2016	Quercetin also activated caspase-3, caspase-9, and poly(ADP-ribose)polymerase 1.	Quercetin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	51-79
27329589-11	2016	Caspase-3 was activated to a greater extent when quercetin was combined with dexamethasone.	Quercetin	49-58	caspase 3	Homo sapiens	0-9
27415000-11	2016	Importantly, stimulated expression of IL-1beta and IL-8 in HaCaT-TNF-alpha were blocked by Quercetin, a flavanol shown to possess anti-TNF-alpha activities.	Quercetin	91-100	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
27415000-11	2016	Importantly, stimulated expression of IL-1beta and IL-8 in HaCaT-TNF-alpha were blocked by Quercetin, a flavanol shown to possess anti-TNF-alpha activities.	Quercetin	91-100	tumor necrosis factor	Homo sapiens	65-74
27415000-11	2016	Importantly, stimulated expression of IL-1beta and IL-8 in HaCaT-TNF-alpha were blocked by Quercetin, a flavanol shown to possess anti-TNF-alpha activities.	Quercetin	91-100	tumor necrosis factor	Homo sapiens	135-144
26835548-8	2016	Concentration (10(-3 )M to 10(-8 )M)-dependent in vitro treatment with quercetin causes inhibition of NHE activity.	Quercetin	71-80	solute carrier family 9 member C1	Homo sapiens	102-105
27191500-4	2016	TRAIL-Rs were up-regulated by anti-inflammatory agents (IL-10, glucocorticoids) and by natural compounds (Apigenin, Quercetin, Palmitate) and their treatment resulted in increased TRAIL-induced apoptosis.	Quercetin	116-125	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	0-5
27191500-4	2016	TRAIL-Rs were up-regulated by anti-inflammatory agents (IL-10, glucocorticoids) and by natural compounds (Apigenin, Quercetin, Palmitate) and their treatment resulted in increased TRAIL-induced apoptosis.	Quercetin	116-125	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	180-185
27383124-10	2016	Treatment with quercetin did not significantly alter HIF-1alpha levels, but did reduce AaPO2 as well as lung tissue NF-kappaB activity, VEGFA gene and protein levels, Akt activity, and angiogenesis.	Quercetin	15-24	vascular endothelial growth factor A	Rattus norvegicus	136-141
27383124-10	2016	Treatment with quercetin did not significantly alter HIF-1alpha levels, but did reduce AaPO2 as well as lung tissue NF-kappaB activity, VEGFA gene and protein levels, Akt activity, and angiogenesis.	Quercetin	15-24	AKT serine/threonine kinase 1	Rattus norvegicus	167-170
27383124-12	2016	Interestingly, quercetin inhibited pulmonary vascular angiogenesis in rats with HPS, with involvement of Akt/NF-kappaB and VEGFA/VEGFR-2 pathways.	Quercetin	15-24	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
27383124-12	2016	Interestingly, quercetin inhibited pulmonary vascular angiogenesis in rats with HPS, with involvement of Akt/NF-kappaB and VEGFA/VEGFR-2 pathways.	Quercetin	15-24	vascular endothelial growth factor A	Rattus norvegicus	123-128
27383124-12	2016	Interestingly, quercetin inhibited pulmonary vascular angiogenesis in rats with HPS, with involvement of Akt/NF-kappaB and VEGFA/VEGFR-2 pathways.	Quercetin	15-24	kinase insert domain receptor	Rattus norvegicus	129-136
27354628-9	2016	Expression of HSP70 and HSF1 was suppressed in the group treated with GGA and quercetin, and this group had severe liver damage.	Quercetin	78-87	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	14-19
27354628-9	2016	Expression of HSP70 and HSF1 was suppressed in the group treated with GGA and quercetin, and this group had severe liver damage.	Quercetin	78-87	heat shock transcription factor 1	Rattus norvegicus	24-28
27399675-0	2016	The Effect of Resveratrol and Quercetin Treatment on PPAR Mediated Uncoupling Protein (UCP-) 1, 2, and 3 Expression in Visceral White Adipose Tissue from Metabolic Syndrome Rats.	Quercetin	30-39	uncoupling protein 1	Rattus norvegicus	53-104
27399675-3	2016	We studied the gene expression regulation of UCP1, -2, and -3 in abdominal white adipose tissue (WAT) from control and MetS rats treated with two doses of a commercial mixture of resveratrol (RSV) and quercetin (QRC).	Quercetin	201-210	uncoupling protein 1	Rattus norvegicus	45-61
27399675-3	2016	We studied the gene expression regulation of UCP1, -2, and -3 in abdominal white adipose tissue (WAT) from control and MetS rats treated with two doses of a commercial mixture of resveratrol (RSV) and quercetin (QRC).	Quercetin	212-215	uncoupling protein 1	Rattus norvegicus	45-61
27399675-9	2016	We conclude that the RSV + QRC treatment leads to overexpression of UCP2, which is associated with an increase in MUFA and PUFA, which might increase PPAR-alpha expression.	Quercetin	27-30	uncoupling protein 2	Rattus norvegicus	68-72
27399675-9	2016	We conclude that the RSV + QRC treatment leads to overexpression of UCP2, which is associated with an increase in MUFA and PUFA, which might increase PPAR-alpha expression.	Quercetin	27-30	peroxisome proliferator activated receptor alpha	Rattus norvegicus	150-160
26835548-0	2016	Quercetin-modulated erythrocyte membrane sodium-hydrogen exchanger during human aging: correlation with ATPase"s.	Quercetin	0-9	dynein axonemal heavy chain 8	Homo sapiens	104-110
27260467-0	2016	Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-gamma associated mechanisms.	Quercetin	0-9	matrix metallopeptidase 2	Homo sapiens	30-35
26581561-4	2016	Amodiaquine, montelukast, quercetin and rosiglitazone, known as substrates or competitive inhibitors of human CYP2C8, were metabolically depleted by recombinant monkey CYP2C8 at relatively high rates.	Quercetin	26-35	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	110-116
26581561-4	2016	Amodiaquine, montelukast, quercetin and rosiglitazone, known as substrates or competitive inhibitors of human CYP2C8, were metabolically depleted by recombinant monkey CYP2C8 at relatively high rates.	Quercetin	26-35	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	168-174
27038916-6	2016	The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles.	Quercetin	177-186	interleukin 1 beta	Homo sapiens	74-92
27038916-6	2016	The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles.	Quercetin	177-186	interleukin 6	Homo sapiens	94-107
27038916-6	2016	The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles.	Quercetin	177-186	tumor necrosis factor	Homo sapiens	113-140
25532488-4	2016	Oxidative stress parameters such as antioxidant enzymes, LPO and PCC levels indicated that quercetin exerted a protective effect on OTA-induced oxidative stress.	Quercetin	91-100	lactoperoxidase	Homo sapiens	57-60
25532488-4	2016	Oxidative stress parameters such as antioxidant enzymes, LPO and PCC levels indicated that quercetin exerted a protective effect on OTA-induced oxidative stress.	Quercetin	91-100	crystallin gamma D	Homo sapiens	65-68
25532488-6	2016	OTA-induced NO, TNF-alpha, IL-6, and IL-8 were significantly reduced in the quercetin pretreated samples indicating its anti-inflammatory role.	Quercetin	76-85	tumor necrosis factor	Homo sapiens	16-25
25532488-6	2016	OTA-induced NO, TNF-alpha, IL-6, and IL-8 were significantly reduced in the quercetin pretreated samples indicating its anti-inflammatory role.	Quercetin	76-85	interleukin 6	Homo sapiens	27-31
25532488-6	2016	OTA-induced NO, TNF-alpha, IL-6, and IL-8 were significantly reduced in the quercetin pretreated samples indicating its anti-inflammatory role.	Quercetin	76-85	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
27087120-8	2016	SHSY5Y cells treated with quercetin also increased the expression of Nrf2 (via a decrease in the levels of Keap1), heme oxygenase-1 (HO-1), and nitric oxide synthase 1 (NOS1), which provide further protection from oxidative stress.	Quercetin	26-35	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
27087120-8	2016	SHSY5Y cells treated with quercetin also increased the expression of Nrf2 (via a decrease in the levels of Keap1), heme oxygenase-1 (HO-1), and nitric oxide synthase 1 (NOS1), which provide further protection from oxidative stress.	Quercetin	26-35	kelch like ECH associated protein 1	Homo sapiens	107-112
27087120-8	2016	SHSY5Y cells treated with quercetin also increased the expression of Nrf2 (via a decrease in the levels of Keap1), heme oxygenase-1 (HO-1), and nitric oxide synthase 1 (NOS1), which provide further protection from oxidative stress.	Quercetin	26-35	heme oxygenase 1	Homo sapiens	115-131
27087120-8	2016	SHSY5Y cells treated with quercetin also increased the expression of Nrf2 (via a decrease in the levels of Keap1), heme oxygenase-1 (HO-1), and nitric oxide synthase 1 (NOS1), which provide further protection from oxidative stress.	Quercetin	26-35	heme oxygenase 1	Homo sapiens	133-137
27087120-8	2016	SHSY5Y cells treated with quercetin also increased the expression of Nrf2 (via a decrease in the levels of Keap1), heme oxygenase-1 (HO-1), and nitric oxide synthase 1 (NOS1), which provide further protection from oxidative stress.	Quercetin	26-35	nitric oxide synthase 1	Homo sapiens	144-167
27087120-8	2016	SHSY5Y cells treated with quercetin also increased the expression of Nrf2 (via a decrease in the levels of Keap1), heme oxygenase-1 (HO-1), and nitric oxide synthase 1 (NOS1), which provide further protection from oxidative stress.	Quercetin	26-35	nitric oxide synthase 1	Homo sapiens	169-173
27087120-10	2016	We hypothesize that SUMOylated HIF-1alpha plays a fundamental role in the protection afforded and may underlie some of quercetin"s ability to protect cells from oxygen/glucose deprivation-induced cell death, via an up-regulation of HO-1 and NOS1, which ultimately leads to the induction of pro-life NOS1/protein kinase G signaling.	Quercetin	119-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-41
27087120-10	2016	We hypothesize that SUMOylated HIF-1alpha plays a fundamental role in the protection afforded and may underlie some of quercetin"s ability to protect cells from oxygen/glucose deprivation-induced cell death, via an up-regulation of HO-1 and NOS1, which ultimately leads to the induction of pro-life NOS1/protein kinase G signaling.	Quercetin	119-128	heme oxygenase 1	Homo sapiens	232-236
27087120-10	2016	We hypothesize that SUMOylated HIF-1alpha plays a fundamental role in the protection afforded and may underlie some of quercetin"s ability to protect cells from oxygen/glucose deprivation-induced cell death, via an up-regulation of HO-1 and NOS1, which ultimately leads to the induction of pro-life NOS1/protein kinase G signaling.	Quercetin	119-128	nitric oxide synthase 1	Homo sapiens	241-245
27087120-10	2016	We hypothesize that SUMOylated HIF-1alpha plays a fundamental role in the protection afforded and may underlie some of quercetin"s ability to protect cells from oxygen/glucose deprivation-induced cell death, via an up-regulation of HO-1 and NOS1, which ultimately leads to the induction of pro-life NOS1/protein kinase G signaling.	Quercetin	119-128	nitric oxide synthase 1	Homo sapiens	299-303
27087120-11	2016	Quercetin acts to increase survival in the face of ischemia via an increase of SENP3 expression, the possible inactivation of SENPs 1/2, and via a decrease in KEAP1 levels (thereby increasing Nrf2 stability).	Quercetin	0-9	SUMO specific peptidase 3	Homo sapiens	79-84
27087120-11	2016	Quercetin acts to increase survival in the face of ischemia via an increase of SENP3 expression, the possible inactivation of SENPs 1/2, and via a decrease in KEAP1 levels (thereby increasing Nrf2 stability).	Quercetin	0-9	SUMO specific peptidase 1	Homo sapiens	126-135
27087120-11	2016	Quercetin acts to increase survival in the face of ischemia via an increase of SENP3 expression, the possible inactivation of SENPs 1/2, and via a decrease in KEAP1 levels (thereby increasing Nrf2 stability).	Quercetin	0-9	kelch like ECH associated protein 1	Homo sapiens	159-164
27087120-11	2016	Quercetin acts to increase survival in the face of ischemia via an increase of SENP3 expression, the possible inactivation of SENPs 1/2, and via a decrease in KEAP1 levels (thereby increasing Nrf2 stability).	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	192-196
27260467-0	2016	Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-gamma associated mechanisms.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	76-86
27260467-1	2016	Our previous study demonstrated that quercetin-metabolite-enriched plasma (QP) but not quercetin itself upregulates peroxisome proliferator-activated receptor gamma (PPAR-gamma) expression to induce G2/M arrest in A549 cells.	Quercetin	37-46	peroxisome proliferator activated receptor gamma	Homo sapiens	116-164
27260467-1	2016	Our previous study demonstrated that quercetin-metabolite-enriched plasma (QP) but not quercetin itself upregulates peroxisome proliferator-activated receptor gamma (PPAR-gamma) expression to induce G2/M arrest in A549 cells.	Quercetin	37-46	peroxisome proliferator activated receptor gamma	Homo sapiens	166-176
27166429-4	2016	In contrast, the basolateral-to-apical transport of AAI was higher than the apical-to-basolateral transport of AAI at pH 7.4, and the former transport was decreased by quercetin and the BCRP inhibitors of Ko-143 and mitoxantrone, but not by P-gp or MRP2 inhibitors.	Quercetin	168-177	phosphoglycolate phosphatase	Homo sapiens	241-245
27260467-6	2016	However, QP and TGZ rather than quercetin itself increased the expressions of nm23-H1 and tissue inhibitor of metalloproteinase (TIMP-2).	Quercetin	32-41	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	78-85
27166429-4	2016	In contrast, the basolateral-to-apical transport of AAI was higher than the apical-to-basolateral transport of AAI at pH 7.4, and the former transport was decreased by quercetin and the BCRP inhibitors of Ko-143 and mitoxantrone, but not by P-gp or MRP2 inhibitors.	Quercetin	168-177	ATP binding cassette subfamily C member 2	Homo sapiens	249-253
27260467-6	2016	However, QP and TGZ rather than quercetin itself increased the expressions of nm23-H1 and tissue inhibitor of metalloproteinase (TIMP-2).	Quercetin	32-41	TIMP metallopeptidase inhibitor 2	Homo sapiens	129-135
27260467-11	2016	The upregulation of PPAR-gamma by quercetin metabolites such as Q3G and Q3"S could play an important role in the effects of QP.	Quercetin	34-43	peroxisome proliferator activated receptor gamma	Homo sapiens	20-30
27176922-5	2016	Molecular-level studies indicated that the DHA + QE combination can significantly inhibit the mRNA expression of NF-kappaB subunits p50 and p65, extracellular signal-regulated kinase (ERK) 1/2 and c-JUN N-terminal kinase (JNK) 1/2, which suggests that the NF-kappaB signalling pathway is involved in the synergistic effects observed.	Quercetin	49-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	132-135
27176922-5	2016	Molecular-level studies indicated that the DHA + QE combination can significantly inhibit the mRNA expression of NF-kappaB subunits p50 and p65, extracellular signal-regulated kinase (ERK) 1/2 and c-JUN N-terminal kinase (JNK) 1/2, which suggests that the NF-kappaB signalling pathway is involved in the synergistic effects observed.	Quercetin	49-51	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	140-143
27176922-5	2016	Molecular-level studies indicated that the DHA + QE combination can significantly inhibit the mRNA expression of NF-kappaB subunits p50 and p65, extracellular signal-regulated kinase (ERK) 1/2 and c-JUN N-terminal kinase (JNK) 1/2, which suggests that the NF-kappaB signalling pathway is involved in the synergistic effects observed.	Quercetin	49-51	mitogen-activated protein kinase 3	Mus musculus	145-192
27176922-5	2016	Molecular-level studies indicated that the DHA + QE combination can significantly inhibit the mRNA expression of NF-kappaB subunits p50 and p65, extracellular signal-regulated kinase (ERK) 1/2 and c-JUN N-terminal kinase (JNK) 1/2, which suggests that the NF-kappaB signalling pathway is involved in the synergistic effects observed.	Quercetin	49-51	mitogen-activated protein kinase 8	Mus musculus	197-230
27176922-6	2016	Furthermore, western blot analysis demonstrated that DHA + QE synergistically inhibit the phosphorylation of p50, p65, ERK1/2 and JNK1/2.	Quercetin	59-61	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	109-112
27176922-6	2016	Furthermore, western blot analysis demonstrated that DHA + QE synergistically inhibit the phosphorylation of p50, p65, ERK1/2 and JNK1/2.	Quercetin	59-61	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	114-117
27176922-6	2016	Furthermore, western blot analysis demonstrated that DHA + QE synergistically inhibit the phosphorylation of p50, p65, ERK1/2 and JNK1/2.	Quercetin	59-61	mitogen-activated protein kinase 3	Mus musculus	119-125
27176922-6	2016	Furthermore, western blot analysis demonstrated that DHA + QE synergistically inhibit the phosphorylation of p50, p65, ERK1/2 and JNK1/2.	Quercetin	59-61	mitogen-activated protein kinase 8	Mus musculus	130-136
26964921-11	2016	Sodium cholate (NaC) was found to show strong interaction towards quercitin (QT) due to more electron density on oxygen atom of carboxylate ion.	Quercetin	66-75	synuclein alpha	Homo sapiens	16-19
26569039-4	2016	Meanwhile, quercetin (7), diosmetin (9) and luteolin (10) inhibited TNF-alpha-induced NF-kappaB reporter gene expression on HeLa cells up to 30 and 100 muM.	Quercetin	11-20	tumor necrosis factor	Homo sapiens	68-77
26569039-4	2016	Meanwhile, quercetin (7), diosmetin (9) and luteolin (10) inhibited TNF-alpha-induced NF-kappaB reporter gene expression on HeLa cells up to 30 and 100 muM.	Quercetin	11-20	latexin	Homo sapiens	152-155
27166148-4	2016	Quercetin effectively inhibited LPS-induced NF-kappaB reporter activity and stimulated Nrf2/ARE reporter activity in DI TNC1 astrocytes.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	87-91
27166148-8	2016	Quercetin and botanical extracts induced Nrf2 and HO-1 protein expression.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	41-45
27347174-0	2016	Quercetin reduces cyclin D1 activity and induces G1 phase arrest in HepG2 cells.	Quercetin	0-9	cyclin D1	Homo sapiens	18-27
27347174-12	2016	Based on the aforementioned observations, it is suggested that quercetin exerts antitumor activity in HepG2 cells through multiple pathways, including interfering with CCND1 gene expression to disrupt the cell cycle and proliferation of HepG2 cells.	Quercetin	63-72	cyclin D1	Homo sapiens	168-173
26964921-11	2016	Sodium cholate (NaC) was found to show strong interaction towards quercitin (QT) due to more electron density on oxygen atom of carboxylate ion.	Quercetin	77-79	synuclein alpha	Homo sapiens	16-19
27286825-8	2016	We also show that the A20-inducing effect of ikarugamycin and quercetin is lower in CF-derived airway epithelial cells than in non-CF cells.	Quercetin	62-71	immunoglobulin kappa variable 1-27	Homo sapiens	22-25
27175602-0	2016	Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	78-128
27175602-0	2016	Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells.	Quercetin	0-9	erb-b2 receptor tyrosine kinase 2	Homo sapiens	142-146
27175602-3	2016	The present study aimed to examine the effect of quercetin on proliferation and apoptosis in HER2-expressing breast cancer cells.	Quercetin	49-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	93-97
27175602-12	2016	Quercetin induced caspase-dependent extrinsic apoptosis upregulating the levels of cleaved caspase-8 and cleaved caspase-3, and inducing the cleavage of poly(ADP-ribose) polymerase (PARP).	Quercetin	0-9	caspase 8	Homo sapiens	91-100
27175602-12	2016	Quercetin induced caspase-dependent extrinsic apoptosis upregulating the levels of cleaved caspase-8 and cleaved caspase-3, and inducing the cleavage of poly(ADP-ribose) polymerase (PARP).	Quercetin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	153-180
27175602-12	2016	Quercetin induced caspase-dependent extrinsic apoptosis upregulating the levels of cleaved caspase-8 and cleaved caspase-3, and inducing the cleavage of poly(ADP-ribose) polymerase (PARP).	Quercetin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	182-186
27175602-14	2016	Quercetin reduced the expression of phospho-JAK1 and phospho-STAT3 and decreased STAT3-dependent luciferase reporter gene activity in the BT-474 cells.	Quercetin	0-9	Janus kinase 1	Homo sapiens	44-48
27175602-14	2016	Quercetin reduced the expression of phospho-JAK1 and phospho-STAT3 and decreased STAT3-dependent luciferase reporter gene activity in the BT-474 cells.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	61-66
27175602-14	2016	Quercetin reduced the expression of phospho-JAK1 and phospho-STAT3 and decreased STAT3-dependent luciferase reporter gene activity in the BT-474 cells.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	81-86
27175602-15	2016	Quercetin inhibited MMP-9 secretion and decreased the nuclear translocation of STAT3.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	20-25
27175602-15	2016	Quercetin inhibited MMP-9 secretion and decreased the nuclear translocation of STAT3.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	79-84
27175602-16	2016	Our study indicates that quercetin induces apoptosis at concentrations &gt;20 microM through inhibition of STAT3 signaling and could serve as a useful compound to prevent or treat HER2-overexpressing breast cancer.	Quercetin	25-34	signal transducer and activator of transcription 3	Homo sapiens	107-112
27175602-16	2016	Our study indicates that quercetin induces apoptosis at concentrations &gt;20 microM through inhibition of STAT3 signaling and could serve as a useful compound to prevent or treat HER2-overexpressing breast cancer.	Quercetin	25-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	180-184
27322259-0	2016	Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation.	Quercetin	15-24	islet amyloid polypeptide	Homo sapiens	49-55
27419199-1	2016	The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-alpha, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice that are given a high-fat diet.	Quercetin	88-97	tumor necrosis factor	Mus musculus	140-149
27419199-1	2016	The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-alpha, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice that are given a high-fat diet.	Quercetin	88-97	intercellular adhesion molecule 1	Mus musculus	151-157
27419199-1	2016	The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-alpha, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice that are given a high-fat diet.	Quercetin	88-97	vascular cell adhesion molecule 1	Mus musculus	159-165
27322259-4	2016	Interestingly, three of the compounds analyzed-benzbromarone, quercetin, and folic acid-are able to slow down amylin fiber formation according to Thioflavin T binding, turbidimetry, and Transmission Electron Microscopy assays.	Quercetin	62-71	islet amyloid polypeptide	Homo sapiens	110-116
27322259-5	2016	In addition to the in vitro assays, we have tested the effect of these compounds in an amyloid toxicity cell culture model and we have found that one of them, quercetin, has the ability to partly protect cultured pancreatic insulinoma cells from the cytotoxic effect of amylin.	Quercetin	159-168	islet amyloid polypeptide	Homo sapiens	270-276
27322259-6	2016	Our data suggests that quercetin can contribute to reduce oxidative damage in pancreatic insulinoma beta cells by modulating the aggregation propensity of amylin.	Quercetin	23-32	islet amyloid polypeptide	Homo sapiens	155-161
27145228-2	2016	In previous studies, the authors reported that a flavonoid, quercetin, reduces the expression of ATF4 and delays memory deterioration in an early-stage AD mouse model.	Quercetin	60-69	activating transcription factor 4	Mus musculus	97-101
28881718-0	2017	Quercetin inhibits Cr(VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway.	Quercetin	0-9	microRNA 21	Homo sapiens	77-83
28881718-0	2017	Quercetin inhibits Cr(VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway.	Quercetin	0-9	programmed cell death 4	Homo sapiens	84-89
28881718-7	2017	Chronic Cr(VI) exposure induced malignant cell transformation, increased miR-21 expression and caused inhibition of PDCD4, which were significantly inhibited by the treatment of quercetin in a dose dependent manner.	Quercetin	178-187	microRNA 21	Homo sapiens	73-79
28881718-7	2017	Chronic Cr(VI) exposure induced malignant cell transformation, increased miR-21 expression and caused inhibition of PDCD4, which were significantly inhibited by the treatment of quercetin in a dose dependent manner.	Quercetin	178-187	programmed cell death 4	Homo sapiens	116-121
28881718-10	2017	Taken together, these results demonstrate that quercetin is able to protect BEAS-2B cells from Cr(VI)-induced carcinogenesis by targeting miR-21-PDCD4 signaling.	Quercetin	47-56	microRNA 21	Homo sapiens	138-144
28881718-10	2017	Taken together, these results demonstrate that quercetin is able to protect BEAS-2B cells from Cr(VI)-induced carcinogenesis by targeting miR-21-PDCD4 signaling.	Quercetin	47-56	programmed cell death 4	Homo sapiens	145-150
27510965-3	2016	In a previous study, we demonstrated that quercetin appears to be a potent anti-tumorigenic agent through its inhibition of the EGFR/Akt pathway in oral cancer, but its anti-metastatic potential in HNSCC remains unclear [1].	Quercetin	42-51	epidermal growth factor receptor	Homo sapiens	128-132
27285995-6	2016	Results show that quercetin was the most effective compound for Akt/mTOR inhibition.	Quercetin	18-27	AKT serine/threonine kinase 1	Homo sapiens	64-67
27285995-6	2016	Results show that quercetin was the most effective compound for Akt/mTOR inhibition.	Quercetin	18-27	mechanistic target of rapamycin kinase	Homo sapiens	68-72
27012965-0	2016	The bioflavonoid quercetin synergises with PPAR-gamma agonist pioglitazone in reducing angiotensin-II contractile effect in fructose-streptozotocin induced diabetic rats.	Quercetin	17-26	angiotensinogen	Rattus norvegicus	87-101
27012965-1	2016	This study investigated the effects of combined minimal concentrations of quercetin and pioglitazone on angiotensin II-induced contraction of the aorta from fructose-streptozotocin (F-STZ)-induced type 2 diabetic rats and the possible role of superoxide anions (O2(-)) and nitric oxide (NO) in their potential therapeutic interaction.	Quercetin	74-83	angiotensinogen	Rattus norvegicus	104-118
27510965-8	2016	Quercetin (10 muM) treatment also suppressed the expression and proteolytic activity of MMP-2 and MMP-9.	Quercetin	0-9	matrix metallopeptidase 2	Homo sapiens	88-93
27510965-8	2016	Quercetin (10 muM) treatment also suppressed the expression and proteolytic activity of MMP-2 and MMP-9.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	98-103
27510965-9	2016	Taken together, our data indicate that quercetin is an effective anti-cancer agent against MMP-2- and MMP-9-mediated metastasis in EGFR-overexpressing HNSCC.	Quercetin	39-48	matrix metallopeptidase 2	Homo sapiens	91-96
27510965-9	2016	Taken together, our data indicate that quercetin is an effective anti-cancer agent against MMP-2- and MMP-9-mediated metastasis in EGFR-overexpressing HNSCC.	Quercetin	39-48	matrix metallopeptidase 9	Homo sapiens	102-107
27510965-9	2016	Taken together, our data indicate that quercetin is an effective anti-cancer agent against MMP-2- and MMP-9-mediated metastasis in EGFR-overexpressing HNSCC.	Quercetin	39-48	epidermal growth factor receptor	Homo sapiens	131-135
27285995-0	2016	Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade.	Quercetin	32-41	AKT serine/threonine kinase 1	Homo sapiens	50-53
27285995-0	2016	Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade.	Quercetin	32-41	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	54-58
27285995-0	2016	Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade.	Quercetin	32-41	mechanistic target of rapamycin kinase	Homo sapiens	59-88
27285995-0	2016	Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade.	Quercetin	32-41	mechanistic target of rapamycin kinase	Homo sapiens	90-94
26944603-7	2016	Administration of quercetin (10 mg/kg body wt/day) reduced aluminum (10 mg/kg body wt/day)-induced oxidative stress (decreased ROS production, increased mitochondrial superoxide dismutase (MnSOD) activity).	Quercetin	18-27	superoxide dismutase 2	Rattus norvegicus	153-187
26944603-7	2016	Administration of quercetin (10 mg/kg body wt/day) reduced aluminum (10 mg/kg body wt/day)-induced oxidative stress (decreased ROS production, increased mitochondrial superoxide dismutase (MnSOD) activity).	Quercetin	18-27	superoxide dismutase 2	Rattus norvegicus	189-194
26944603-8	2016	In addition, quercetin also prevents aluminum-induced translocation of cyt-c, and up-regulates Bcl-2, down-regulates Bax, p53, caspase-3 activation and reduces DNA fragmentation.	Quercetin	13-22	BCL2, apoptosis regulator	Rattus norvegicus	95-100
26944603-8	2016	In addition, quercetin also prevents aluminum-induced translocation of cyt-c, and up-regulates Bcl-2, down-regulates Bax, p53, caspase-3 activation and reduces DNA fragmentation.	Quercetin	13-22	BCL2 associated X, apoptosis regulator	Rattus norvegicus	117-120
26944603-8	2016	In addition, quercetin also prevents aluminum-induced translocation of cyt-c, and up-regulates Bcl-2, down-regulates Bax, p53, caspase-3 activation and reduces DNA fragmentation.	Quercetin	13-22	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	122-125
26944603-8	2016	In addition, quercetin also prevents aluminum-induced translocation of cyt-c, and up-regulates Bcl-2, down-regulates Bax, p53, caspase-3 activation and reduces DNA fragmentation.	Quercetin	13-22	caspase 3	Rattus norvegicus	127-136
26521059-9	2016	GST activity was significantly increased in the Cr-treated animals, and this was further increased in groups treated with Cr and quercetin (all doses).	Quercetin	129-138	hematopoietic prostaglandin D synthase	Mus musculus	0-3
26521059-12	2016	Nevertheless, co-treatment with quercetin (25 and 50 mg/kg) resulted in significant decrease in catalase activity.	Quercetin	32-41	catalase	Mus musculus	96-104
27510965-3	2016	In a previous study, we demonstrated that quercetin appears to be a potent anti-tumorigenic agent through its inhibition of the EGFR/Akt pathway in oral cancer, but its anti-metastatic potential in HNSCC remains unclear [1].	Quercetin	42-51	AKT serine/threonine kinase 1	Homo sapiens	133-136
27510965-4	2016	Here, we have hypothesized that quercetin might be effective in metastatic inhibition in EGFR-overexpressing HNSCC cells.	Quercetin	32-41	epidermal growth factor receptor	Homo sapiens	89-93
27510965-5	2016	Quercetin treatment with 10 muM (half concentration of IC50) suppressed cell migration and invasion in EGFR-overexpressing HSC-3 and FaDu HNSCC cells.	Quercetin	0-9	latexin	Homo sapiens	28-31
27510965-5	2016	Quercetin treatment with 10 muM (half concentration of IC50) suppressed cell migration and invasion in EGFR-overexpressing HSC-3 and FaDu HNSCC cells.	Quercetin	0-9	epidermal growth factor receptor	Homo sapiens	103-107
27510965-5	2016	Quercetin treatment with 10 muM (half concentration of IC50) suppressed cell migration and invasion in EGFR-overexpressing HSC-3 and FaDu HNSCC cells.	Quercetin	0-9	DnaJ heat shock protein family (Hsp40) member B7	Homo sapiens	123-128
27510965-6	2016	Quercetin also inhibited the colony growth of HSC-3 cells embedded in a Matrigel matrix.	Quercetin	0-9	DnaJ heat shock protein family (Hsp40) member B7	Homo sapiens	46-51
27510965-8	2016	Quercetin (10 muM) treatment also suppressed the expression and proteolytic activity of MMP-2 and MMP-9.	Quercetin	0-9	latexin	Homo sapiens	14-17
27142748-5	2016	Quercetin (10muM) inhibited cell proliferation, alkaline phosphatase (ALPL) activity and mineralization, down-regulating the expression of ALPL, collagen type I alpha 1 (COL1A1) and osteocalcin [bone gamma-carboxyglutamate protein (BGLAP)] osteoblastogenesis-related genes in MSC differentiating into osteoblasts.	Quercetin	0-9	alkaline phosphatase, biomineralization associated	Homo sapiens	70-74
26706102-5	2016	The results showed that the sugar-conjugated platinum(II) complexes can be recognized by the glucose recognition binding site of GLUT1 and their cell killing effect depends highly on the GLUT1 inhibitor, quercetin.	Quercetin	204-213	solute carrier family 2 member 1	Homo sapiens	129-134
26706102-5	2016	The results showed that the sugar-conjugated platinum(II) complexes can be recognized by the glucose recognition binding site of GLUT1 and their cell killing effect depends highly on the GLUT1 inhibitor, quercetin.	Quercetin	204-213	solute carrier family 2 member 1	Homo sapiens	187-192
27142748-5	2016	Quercetin (10muM) inhibited cell proliferation, alkaline phosphatase (ALPL) activity and mineralization, down-regulating the expression of ALPL, collagen type I alpha 1 (COL1A1) and osteocalcin [bone gamma-carboxyglutamate protein (BGLAP)] osteoblastogenesis-related genes in MSC differentiating into osteoblasts.	Quercetin	0-9	alkaline phosphatase, biomineralization associated	Homo sapiens	139-143
27142748-5	2016	Quercetin (10muM) inhibited cell proliferation, alkaline phosphatase (ALPL) activity and mineralization, down-regulating the expression of ALPL, collagen type I alpha 1 (COL1A1) and osteocalcin [bone gamma-carboxyglutamate protein (BGLAP)] osteoblastogenesis-related genes in MSC differentiating into osteoblasts.	Quercetin	0-9	collagen type I alpha 1 chain	Homo sapiens	145-168
27142748-5	2016	Quercetin (10muM) inhibited cell proliferation, alkaline phosphatase (ALPL) activity and mineralization, down-regulating the expression of ALPL, collagen type I alpha 1 (COL1A1) and osteocalcin [bone gamma-carboxyglutamate protein (BGLAP)] osteoblastogenesis-related genes in MSC differentiating into osteoblasts.	Quercetin	0-9	collagen type I alpha 1 chain	Homo sapiens	170-176
27386150-0	2016	Modulation of the Expression of the GABAA Receptor beta1 and beta3 Subunits by Pretreatment with Quercetin in the KA Model of Epilepsy in Mice: -The Effect of Quercetin on GABAA Receptor Beta Subunits.	Quercetin	97-106	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	36-41
27142748-5	2016	Quercetin (10muM) inhibited cell proliferation, alkaline phosphatase (ALPL) activity and mineralization, down-regulating the expression of ALPL, collagen type I alpha 1 (COL1A1) and osteocalcin [bone gamma-carboxyglutamate protein (BGLAP)] osteoblastogenesis-related genes in MSC differentiating into osteoblasts.	Quercetin	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	182-193
27386150-3	2016	This study evaluated the role of quercetin pretreatment on gene expression of gamma-amino butyric acid type A (GABAA) receptor beta subunits in kainic acid (KA)-induced seizures in mice.	Quercetin	33-42	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	111-116
27142748-5	2016	Quercetin (10muM) inhibited cell proliferation, alkaline phosphatase (ALPL) activity and mineralization, down-regulating the expression of ALPL, collagen type I alpha 1 (COL1A1) and osteocalcin [bone gamma-carboxyglutamate protein (BGLAP)] osteoblastogenesis-related genes in MSC differentiating into osteoblasts.	Quercetin	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	195-230
27386150-7	2016	RESULTS: Pretreatments with quercetin at doses of 50 and 100 mg/kg prevented significant increases in the mRNA levels of the beta 1 and the beta 3 subunits of the GABAA receptor at 2 hours after KA injection.	Quercetin	28-37	hemoglobin, beta adult major chain	Mus musculus	125-146
27386150-7	2016	RESULTS: Pretreatments with quercetin at doses of 50 and 100 mg/kg prevented significant increases in the mRNA levels of the beta 1 and the beta 3 subunits of the GABAA receptor at 2 hours after KA injection.	Quercetin	28-37	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	163-168
27142748-5	2016	Quercetin (10muM) inhibited cell proliferation, alkaline phosphatase (ALPL) activity and mineralization, down-regulating the expression of ALPL, collagen type I alpha 1 (COL1A1) and osteocalcin [bone gamma-carboxyglutamate protein (BGLAP)] osteoblastogenesis-related genes in MSC differentiating into osteoblasts.	Quercetin	0-9	bone gamma-carboxyglutamate protein	Homo sapiens	232-237
27386150-8	2016	Pretreatment with quercetin (100 mg/kg) significantly inhibited beta 1 and beta 3 gene expression in the hippocampus at 7 days after KA injection.	Quercetin	18-27	hemoglobin, beta adult major chain	Mus musculus	64-81
27142748-8	2016	beta- and gamma-catenin (plakoglobin) nuclear levels were reduced and increased, respectively, in quercetin-treated cultures.	Quercetin	98-107	catenin beta 1	Homo sapiens	0-23
27142748-9	2016	This suggests that the effect of high concentration of quercetin on MSC osteoblastic and adipogenic differentiation is mediated via Wnt/beta-catenin inhibition.	Quercetin	55-64	catenin beta 1	Homo sapiens	136-148
27386150-9	2016	But, this inhibitory effect of quercetin at 50 mg/kg on the mRNA levels of the beta 3 subunit of the GABAA receptor was not observed at 7 days after KA administration.	Quercetin	31-40	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	79-85
26222269-5	2016	In a restraint-induced oxidative stress model in mice, quercetin significantly attenuated the increase in plasma ALT and AST levels as well as liver MDA content of restrained mice.	Quercetin	55-64	glutamic pyruvic transaminase, soluble	Mus musculus	113-116
27386150-9	2016	But, this inhibitory effect of quercetin at 50 mg/kg on the mRNA levels of the beta 3 subunit of the GABAA receptor was not observed at 7 days after KA administration.	Quercetin	31-40	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	101-106
27386150-10	2016	CONCLUSION: These results suggest that quercetin (100 mg/kg) modulates the expression of the GABAA receptor beta 1 and beta 3 subunits in the KA model of epilepsy, most likely to prevent compensatory responses.	Quercetin	39-48	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	93-125
27017606-12	2016	An in vitro isotope tracing experiment showed that COT and its bioactive ingredients, such as celastrol, ursolic acid, oleanolic acid, and quercetin, significantly increased the efflux of (3)H-cholesterol.	Quercetin	139-148	mitogen-activated protein kinase kinase kinase 8	Mus musculus	51-54
26222269-5	2016	In a restraint-induced oxidative stress model in mice, quercetin significantly attenuated the increase in plasma ALT and AST levels as well as liver MDA content of restrained mice.	Quercetin	55-64	transmembrane protease, serine 11d	Mus musculus	121-124
30192489-5	2016	It was shown for the first time that quercetin pretreatment inhibited the LC-induced expression of Hsp70 in the SNpc neurons and increased in 1.5 times the dopamine (DA)-ergic neurons death and in 2.7 times the striatal DA-ergic axons degeneration.	Quercetin	37-46	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	99-104
25557047-6	2016	Consistent with the inhibitory activity of quercetin on the enzyme transglutaminase 2 (TG2), genetic ablation of TG2 in mice mirrors the effects of quercetin on birth outcomes and follicular development.	Quercetin	43-52	transglutaminase 2, C polypeptide	Mus musculus	67-85
25557047-6	2016	Consistent with the inhibitory activity of quercetin on the enzyme transglutaminase 2 (TG2), genetic ablation of TG2 in mice mirrors the effects of quercetin on birth outcomes and follicular development.	Quercetin	43-52	transglutaminase 2, C polypeptide	Mus musculus	87-90
25557047-6	2016	Consistent with the inhibitory activity of quercetin on the enzyme transglutaminase 2 (TG2), genetic ablation of TG2 in mice mirrors the effects of quercetin on birth outcomes and follicular development.	Quercetin	43-52	transglutaminase 2, C polypeptide	Mus musculus	113-116
25557047-6	2016	Consistent with the inhibitory activity of quercetin on the enzyme transglutaminase 2 (TG2), genetic ablation of TG2 in mice mirrors the effects of quercetin on birth outcomes and follicular development.	Quercetin	148-157	transglutaminase 2, C polypeptide	Mus musculus	67-85
25557047-6	2016	Consistent with the inhibitory activity of quercetin on the enzyme transglutaminase 2 (TG2), genetic ablation of TG2 in mice mirrors the effects of quercetin on birth outcomes and follicular development.	Quercetin	148-157	transglutaminase 2, C polypeptide	Mus musculus	113-116
25557047-8	2016	Our study shows for the first time that dietary quercetin can cause reduced reproductive potential in female mice and implies that TG2 may regulate ovarian ageing.	Quercetin	48-57	transglutaminase 2, C polypeptide	Mus musculus	131-134
27207147-11	2016	Oral administration of quercetin at more than 25 mg/kg for 5 days significantly inhibited the increase in SP, CGRP and NGF contents in nasal lavage fluids induced by TDI nasal challenge.	Quercetin	23-32	calcitonin-related polypeptide alpha	Rattus norvegicus	110-114
26108947-5	2016	The compounds were ranked based on Glide extra precision docking score and five hits (curcumin, quercetin, morin, naringin and silibinin) were selected on the basis of their interaction with active site amino acid residues of GLO-I.	Quercetin	96-105	glyoxalase I	Homo sapiens	226-231
26806540-0	2016	Activation of transient receptor potential ankyrin 1 by quercetin and its analogs.	Quercetin	56-65	transient receptor potential cation channel subfamily A member 1	Homo sapiens	14-52
26806540-1	2016	The agonistic activity of quercetin and its analogs towards the transient receptor potential ankyrin 1 (TRPA1) has been experimentally investigated.	Quercetin	26-35	transient receptor potential cation channel subfamily A member 1	Homo sapiens	64-102
26806540-1	2016	The agonistic activity of quercetin and its analogs towards the transient receptor potential ankyrin 1 (TRPA1) has been experimentally investigated.	Quercetin	26-35	transient receptor potential cation channel subfamily A member 1	Homo sapiens	104-109
27033602-4	2016	The GLUT specificity of the probes was validated with quercetin, which is both a permeant substrate via GLUTs and a high-affinity inhibitor of GLUT-mediated glucose transport.	Quercetin	54-63	solute carrier family 2 member 1	Homo sapiens	4-8
27033602-4	2016	The GLUT specificity of the probes was validated with quercetin, which is both a permeant substrate via GLUTs and a high-affinity inhibitor of GLUT-mediated glucose transport.	Quercetin	54-63	solute carrier family 2 member 1	Homo sapiens	104-108
27187453-5	2016	We revealed for the first time that quercetin significantly changed expression of adipokine (Angptl4, adipsin, irisin and PAI-1) and glycolysis-involved (ENO2, PFKP and PFKFB4) genes, and that this effect not only antagonized but in part even overcompensated the effect mediated by hypoxia in adipocytes.	Quercetin	36-45	angiopoietin like 4	Homo sapiens	93-100
27187453-5	2016	We revealed for the first time that quercetin significantly changed expression of adipokine (Angptl4, adipsin, irisin and PAI-1) and glycolysis-involved (ENO2, PFKP and PFKFB4) genes, and that this effect not only antagonized but in part even overcompensated the effect mediated by hypoxia in adipocytes.	Quercetin	36-45	complement factor D	Homo sapiens	102-109
27187453-5	2016	We revealed for the first time that quercetin significantly changed expression of adipokine (Angptl4, adipsin, irisin and PAI-1) and glycolysis-involved (ENO2, PFKP and PFKFB4) genes, and that this effect not only antagonized but in part even overcompensated the effect mediated by hypoxia in adipocytes.	Quercetin	36-45	fibronectin type III domain containing 5	Homo sapiens	111-117
27187453-5	2016	We revealed for the first time that quercetin significantly changed expression of adipokine (Angptl4, adipsin, irisin and PAI-1) and glycolysis-involved (ENO2, PFKP and PFKFB4) genes, and that this effect not only antagonized but in part even overcompensated the effect mediated by hypoxia in adipocytes.	Quercetin	36-45	serpin family E member 1	Homo sapiens	122-127
27187453-5	2016	We revealed for the first time that quercetin significantly changed expression of adipokine (Angptl4, adipsin, irisin and PAI-1) and glycolysis-involved (ENO2, PFKP and PFKFB4) genes, and that this effect not only antagonized but in part even overcompensated the effect mediated by hypoxia in adipocytes.	Quercetin	36-45	enolase 2	Homo sapiens	154-158
27187453-5	2016	We revealed for the first time that quercetin significantly changed expression of adipokine (Angptl4, adipsin, irisin and PAI-1) and glycolysis-involved (ENO2, PFKP and PFKFB4) genes, and that this effect not only antagonized but in part even overcompensated the effect mediated by hypoxia in adipocytes.	Quercetin	36-45	phosphofructokinase, platelet	Homo sapiens	160-164
27187453-5	2016	We revealed for the first time that quercetin significantly changed expression of adipokine (Angptl4, adipsin, irisin and PAI-1) and glycolysis-involved (ENO2, PFKP and PFKFB4) genes, and that this effect not only antagonized but in part even overcompensated the effect mediated by hypoxia in adipocytes.	Quercetin	36-45	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	169-175
27133425-5	2016	Phosphorylation of Akt, a key phosphorylation pathway of suppression of protein degradation, was activated in the quercetin-mixed diet group with and without SNX surgery.	Quercetin	114-123	thymoma viral proto-oncogene 1	Mus musculus	19-22
27052533-7	2016	Concentrations of serum C-reactive protein were reduced 29% in quercetin-fed mice compared with HF-fed controls (P &lt; 0.05).	Quercetin	63-72	C-reactive protein, pentraxin-related	Mus musculus	24-42
27133425-6	2016	Intake of a quercetin-mixed diet suppressed the generation of hydrogen peroxide originating from mitochondria and elevated mitochondrial peroxisome proliferator-activated receptor-gamma coactivator 1alpha mRNA expression as well as NADH dehydrogenase 4 expression in the GM with SNX surgery.	Quercetin	12-21	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	137-204
27050422-0	2016	Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3beta Signaling Pathways in HT22 Hippocampal Neurons.	Quercetin	0-9	glycogen synthase kinase 3 beta	Mus musculus	77-85
26865218-3	2016	METHODS AND RESULTS: Coadministration of quercetin and valinomycin (50 muM quercetin/0.05 muM valinomycin) reduced intracellular reactive oxygen species content and increased cell viability (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) of Caco-2 cells compared to valinomycin-only (0.05 muM) treatment.	Quercetin	41-50	latexin	Homo sapiens	71-74
26865218-3	2016	METHODS AND RESULTS: Coadministration of quercetin and valinomycin (50 muM quercetin/0.05 muM valinomycin) reduced intracellular reactive oxygen species content and increased cell viability (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) of Caco-2 cells compared to valinomycin-only (0.05 muM) treatment.	Quercetin	41-50	latexin	Homo sapiens	90-93
26865218-3	2016	METHODS AND RESULTS: Coadministration of quercetin and valinomycin (50 muM quercetin/0.05 muM valinomycin) reduced intracellular reactive oxygen species content and increased cell viability (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) of Caco-2 cells compared to valinomycin-only (0.05 muM) treatment.	Quercetin	41-50	latexin	Homo sapiens	90-93
26865218-3	2016	METHODS AND RESULTS: Coadministration of quercetin and valinomycin (50 muM quercetin/0.05 muM valinomycin) reduced intracellular reactive oxygen species content and increased cell viability (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) of Caco-2 cells compared to valinomycin-only (0.05 muM) treatment.	Quercetin	75-84	latexin	Homo sapiens	71-74
27095146-8	2016	Results indicated that hypaconitine, mesaconitine, higenamine and quercetin in SND can directly bind to TNF-alpha, reduce the TNF-alpha-mediated cytotoxicity on L929 cells and exert anti-myocardial cell apoptosis effects.	Quercetin	66-75	tumor necrosis factor	Mus musculus	104-113
27095146-8	2016	Results indicated that hypaconitine, mesaconitine, higenamine and quercetin in SND can directly bind to TNF-alpha, reduce the TNF-alpha-mediated cytotoxicity on L929 cells and exert anti-myocardial cell apoptosis effects.	Quercetin	66-75	tumor necrosis factor	Mus musculus	126-135
27052477-7	2016	Similar to those findings in the obstructive kidneys, mTORC1, mTORC2 and beta-catenin, but not Smad signaling pathways were remarkably blocked by quercetin treatment.	Quercetin	146-155	catenin beta 1	Homo sapiens	73-85
27052477-8	2016	Together, these results suggest that quercetin inhibits fibroblast activation and kidney fibrosis involving a combined inhibition of mTOR and beta-catenin signaling transduction, which may act as a therapeutic candidate for patients with chronic kidney diseases.	Quercetin	37-46	mechanistic target of rapamycin kinase	Homo sapiens	133-137
27052477-8	2016	Together, these results suggest that quercetin inhibits fibroblast activation and kidney fibrosis involving a combined inhibition of mTOR and beta-catenin signaling transduction, which may act as a therapeutic candidate for patients with chronic kidney diseases.	Quercetin	37-46	catenin beta 1	Homo sapiens	142-154
27050422-0	2016	Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3beta Signaling Pathways in HT22 Hippocampal Neurons.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	73-76
25968914-0	2016	Quercetin regulates beta-catenin signaling and reduces the migration of triple negative breast cancer.	Quercetin	0-9	catenin beta 1	Homo sapiens	20-32
25968914-6	2016	Our data indicated that quercetin can induce the expression of E-cadherin and also downregulate vimentin levels in TNBC.	Quercetin	24-33	cadherin 1	Homo sapiens	63-73
25968914-6	2016	Our data indicated that quercetin can induce the expression of E-cadherin and also downregulate vimentin levels in TNBC.	Quercetin	24-33	vimentin	Homo sapiens	96-104
25968914-8	2016	Quercetin-induced MET was linked with the alteration of nuclear localization of beta-catenin and modulation of beta-catenin target genes such as cyclin D1 and c-Myc.	Quercetin	0-9	catenin beta 1	Homo sapiens	80-92
25968914-8	2016	Quercetin-induced MET was linked with the alteration of nuclear localization of beta-catenin and modulation of beta-catenin target genes such as cyclin D1 and c-Myc.	Quercetin	0-9	catenin beta 1	Homo sapiens	111-123
25968914-8	2016	Quercetin-induced MET was linked with the alteration of nuclear localization of beta-catenin and modulation of beta-catenin target genes such as cyclin D1 and c-Myc.	Quercetin	0-9	cyclin D1	Homo sapiens	145-154
25968914-8	2016	Quercetin-induced MET was linked with the alteration of nuclear localization of beta-catenin and modulation of beta-catenin target genes such as cyclin D1 and c-Myc.	Quercetin	0-9	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	159-164
26986492-8	2016	In subsequent investigations of the RCM-altered signaling pathway, RCM extract, ellagic acid and quercetin were found to commonly induce the phosphorylation of JNK and AKT.	Quercetin	97-106	mitogen-activated protein kinase 8	Homo sapiens	160-163
26986492-8	2016	In subsequent investigations of the RCM-altered signaling pathway, RCM extract, ellagic acid and quercetin were found to commonly induce the phosphorylation of JNK and AKT.	Quercetin	97-106	AKT serine/threonine kinase 1	Homo sapiens	168-171
26986492-9	2016	Additionally, the inhibition of JNK with SP600125 repressed the apoptotic cell death induced by RCM extract, ellagic acid and quercetin, and the inhibition of JNK appeared to switch apoptosis to necrosis.	Quercetin	126-135	mitogen-activated protein kinase 8	Homo sapiens	32-35
26986492-10	2016	JNK inhibition also reduced the phosphorylation of AKT, which was induced by RCM extract, ellagic acid and quercetin, suggesting that the phosphorylation of JNK is required for AKT phosphorylation in RCM-, ellagic acid- or quercetin-induced apoptotic cell death.	Quercetin	107-116	mitogen-activated protein kinase 8	Homo sapiens	0-3
26986492-10	2016	JNK inhibition also reduced the phosphorylation of AKT, which was induced by RCM extract, ellagic acid and quercetin, suggesting that the phosphorylation of JNK is required for AKT phosphorylation in RCM-, ellagic acid- or quercetin-induced apoptotic cell death.	Quercetin	107-116	AKT serine/threonine kinase 1	Homo sapiens	51-54
26986492-10	2016	JNK inhibition also reduced the phosphorylation of AKT, which was induced by RCM extract, ellagic acid and quercetin, suggesting that the phosphorylation of JNK is required for AKT phosphorylation in RCM-, ellagic acid- or quercetin-induced apoptotic cell death.	Quercetin	107-116	mitogen-activated protein kinase 8	Homo sapiens	157-160
26986492-10	2016	JNK inhibition also reduced the phosphorylation of AKT, which was induced by RCM extract, ellagic acid and quercetin, suggesting that the phosphorylation of JNK is required for AKT phosphorylation in RCM-, ellagic acid- or quercetin-induced apoptotic cell death.	Quercetin	107-116	AKT serine/threonine kinase 1	Homo sapiens	177-180
26986492-10	2016	JNK inhibition also reduced the phosphorylation of AKT, which was induced by RCM extract, ellagic acid and quercetin, suggesting that the phosphorylation of JNK is required for AKT phosphorylation in RCM-, ellagic acid- or quercetin-induced apoptotic cell death.	Quercetin	223-232	mitogen-activated protein kinase 8	Homo sapiens	0-3
26986492-10	2016	JNK inhibition also reduced the phosphorylation of AKT, which was induced by RCM extract, ellagic acid and quercetin, suggesting that the phosphorylation of JNK is required for AKT phosphorylation in RCM-, ellagic acid- or quercetin-induced apoptotic cell death.	Quercetin	223-232	AKT serine/threonine kinase 1	Homo sapiens	51-54
26986492-10	2016	JNK inhibition also reduced the phosphorylation of AKT, which was induced by RCM extract, ellagic acid and quercetin, suggesting that the phosphorylation of JNK is required for AKT phosphorylation in RCM-, ellagic acid- or quercetin-induced apoptotic cell death.	Quercetin	223-232	mitogen-activated protein kinase 8	Homo sapiens	157-160
26986492-10	2016	JNK inhibition also reduced the phosphorylation of AKT, which was induced by RCM extract, ellagic acid and quercetin, suggesting that the phosphorylation of JNK is required for AKT phosphorylation in RCM-, ellagic acid- or quercetin-induced apoptotic cell death.	Quercetin	223-232	AKT serine/threonine kinase 1	Homo sapiens	177-180
27279714-0	2016	Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway.	Quercetin	0-9	toll like receptor 4	Homo sapiens	102-122
27279714-0	2016	Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	123-145
27279714-8	2016	RESULTS: The concentration of quercetin &lt;20 muM was chosen for further experiments.	Quercetin	30-39	latexin	Homo sapiens	47-50
27279714-9	2016	Quercetin (5 muM) could remarkably suppress the migratory and invasive capacity of Caco-2 cells.	Quercetin	0-9	latexin	Homo sapiens	13-16
27279714-10	2016	The expressions of metastasis-related proteins of MMP-2, MMP-9 were decreased, whereas the expression of E-cadherin protein was increased by quercetin in a dose-dependent manner.	Quercetin	141-150	cadherin 1	Homo sapiens	105-115
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	Quercetin	122-131	toll like receptor 4	Homo sapiens	24-28
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	Quercetin	122-131	latexin	Homo sapiens	86-89
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	Quercetin	122-131	matrix metallopeptidase 9	Homo sapiens	209-214
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	Quercetin	122-131	cadherin 1	Homo sapiens	216-226
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	Quercetin	122-131	toll like receptor 4	Homo sapiens	228-232
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	Quercetin	122-131	nuclear factor kappa B subunit 1	Homo sapiens	238-247
27279714-11	2016	Interestingly, the anti-TLR4 (2 mug) antibody or pyrrolidine dithiocarbamate (PDTC; 1 muM) could affect the inhibition of quercetin on cell migration and invasion, as well as the protein expressions of MMP-2, MMP-9, E-cadherin, TLR4, and NF-kappaB p65.	Quercetin	122-131	RELA proto-oncogene, NF-kB subunit	Homo sapiens	248-251
27279714-12	2016	In addition, quercetin could reduce the inflammation factors production of TNF-alpha, Cox-2, and IL-6.	Quercetin	13-22	tumor necrosis factor	Homo sapiens	75-84
27279714-12	2016	In addition, quercetin could reduce the inflammation factors production of TNF-alpha, Cox-2, and IL-6.	Quercetin	13-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
27279714-12	2016	In addition, quercetin could reduce the inflammation factors production of TNF-alpha, Cox-2, and IL-6.	Quercetin	13-22	interleukin 6	Homo sapiens	97-101
27279714-13	2016	CONCLUSION: The findings suggested for the 1(st) time that quercetin might exert its anticolon cancer activity via the TLR4- and/or NF-kappaB-mediated signaling pathway.	Quercetin	59-68	toll like receptor 4	Homo sapiens	119-123
27279714-13	2016	CONCLUSION: The findings suggested for the 1(st) time that quercetin might exert its anticolon cancer activity via the TLR4- and/or NF-kappaB-mediated signaling pathway.	Quercetin	59-68	nuclear factor kappa B subunit 1	Homo sapiens	132-141
27052477-0	2016	Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and beta-catenin Signaling.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	90-119
27052477-0	2016	Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and beta-catenin Signaling.	Quercetin	0-9	catenin beta 1	Homo sapiens	124-136
27052477-4	2016	MTORC1, mTORC2, beta-catenin as well as Smad signaling were activated in the obstructive kidneys, whereas quercetin could markedly reduce their abundance except Smad3 phosphorylation.	Quercetin	106-115	SMAD family member 3	Homo sapiens	161-166
27052477-5	2016	In cultured NRK-49F cells, quercetin could inhibit alpha-SMA and fibronectin (FN) expression induced by TGFbeta1 treatment.	Quercetin	27-36	fibronectin 1	Rattus norvegicus	65-76
27052477-5	2016	In cultured NRK-49F cells, quercetin could inhibit alpha-SMA and fibronectin (FN) expression induced by TGFbeta1 treatment.	Quercetin	27-36	fibronectin 1	Rattus norvegicus	78-80
27052477-5	2016	In cultured NRK-49F cells, quercetin could inhibit alpha-SMA and fibronectin (FN) expression induced by TGFbeta1 treatment.	Quercetin	27-36	transforming growth factor, beta 1	Rattus norvegicus	104-112
27052477-7	2016	Similar to those findings in the obstructive kidneys, mTORC1, mTORC2 and beta-catenin, but not Smad signaling pathways were remarkably blocked by quercetin treatment.	Quercetin	146-155	CREB regulated transcription coactivator 1	Mus musculus	54-60
27052477-7	2016	Similar to those findings in the obstructive kidneys, mTORC1, mTORC2 and beta-catenin, but not Smad signaling pathways were remarkably blocked by quercetin treatment.	Quercetin	146-155	CREB regulated transcription coactivator 2	Mus musculus	62-68
27050422-9	2016	Moreover, pre-treatment with quercetin not only inhibited OA-induced apoptosis via the reduction of Bax, and up-regulation of cleaved caspase 3, but also via the inhibition of PI3K/Akt/GSK3beta, MAPKs and activation of NF-kappaB p65.	Quercetin	29-38	BCL2-associated X protein	Mus musculus	100-103
27050422-9	2016	Moreover, pre-treatment with quercetin not only inhibited OA-induced apoptosis via the reduction of Bax, and up-regulation of cleaved caspase 3, but also via the inhibition of PI3K/Akt/GSK3beta, MAPKs and activation of NF-kappaB p65.	Quercetin	29-38	thymoma viral proto-oncogene 1	Mus musculus	181-184
27050422-9	2016	Moreover, pre-treatment with quercetin not only inhibited OA-induced apoptosis via the reduction of Bax, and up-regulation of cleaved caspase 3, but also via the inhibition of PI3K/Akt/GSK3beta, MAPKs and activation of NF-kappaB p65.	Quercetin	29-38	glycogen synthase kinase 3 beta	Mus musculus	185-193
27050422-9	2016	Moreover, pre-treatment with quercetin not only inhibited OA-induced apoptosis via the reduction of Bax, and up-regulation of cleaved caspase 3, but also via the inhibition of PI3K/Akt/GSK3beta, MAPKs and activation of NF-kappaB p65.	Quercetin	29-38	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	229-232
27065883-1	2016	We examined the inhibitory effects of three flavonolignans and their dehydro- derivatives, taxifolin and quercetin on the activity of the Na(+)/K(+)-ATPase (NKA).	Quercetin	105-114	tachykinin precursor 1	Homo sapiens	138-155
27039073-0	2016	Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo.	Quercetin	0-9	heat shock protein 1	Mus musculus	66-71
27039073-0	2016	Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo.	Quercetin	0-9	cytochrome c oxidase II, mitochondrial	Mus musculus	76-81
26718867-0	2016	Experimental evidence and molecular modeling of the interaction between hRSV-NS1 and quercetin.	Quercetin	85-94	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	77-80
26718867-5	2016	The aims of this study include the expression and purification of the NS1 protein besides experimental and computational assays of the NS1-quercetin interaction.	Quercetin	139-148	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	135-138
26718867-7	2016	The melting temperature obtained through DSC analysis was around 56 C. FRET analysis showed a distance of approximately 19A between the NS1 and quercetin.	Quercetin	144-153	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	136-139
26718867-8	2016	Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions.	Quercetin	80-89	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	76-79
26718867-8	2016	Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions.	Quercetin	80-89	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	209-212
26718867-8	2016	Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions.	Quercetin	213-222	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	76-79
26718867-8	2016	Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions.	Quercetin	213-222	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	209-212
26718867-9	2016	The computational results from the molecular modeling for NS1 structure and molecular docking regarding its interaction with quercetin corroborate the experimental data.	Quercetin	125-134	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	58-61
26656634-5	2016	Quercetin-loaded NPs can significantly block UVB irradiation induced COX-2 up-expression and NF-kB activation in Hacat cell line.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
27160136-0	2016	Quercetin inhibits angiotensin II induced apoptosis via mitochondrial pathway in human umbilical vein endothelial cells.	Quercetin	0-9	angiotensinogen	Homo sapiens	19-33
27160136-4	2016	In this study, we attempted to clarify the effect of quercetin on Ang II induced apoptosis.	Quercetin	53-62	angiotensinogen	Homo sapiens	66-72
27160136-12	2016	Quercetin inhibited the effect of Ang II on HUVECs in a concentration- and time-dependent manner.	Quercetin	0-9	angiotensinogen	Homo sapiens	34-40
27160136-13	2016	Furthermore, the loss of mitochondrial membrane potential, upregulation of cytochrome c and Bax, downregulation of Bcl-2, and activation of caspase-9 and caspase-3 caused by angiotensin II were also recovered after treated with quercetin.	Quercetin	228-237	angiotensinogen	Homo sapiens	174-188
27160136-14	2016	CONCLUSIONS: Quercetin could inhibit Ang II induced apoptosis of human umbilical vein endothelial cells via the mitochondrial pathway.	Quercetin	13-22	angiotensinogen	Homo sapiens	37-43
26778209-0	2016	The dietary flavonol quercetin ameliorates angiotensin II-induced redox signaling imbalance in a human umbilical vein endothelial cell model of endothelial dysfunction via ablation of p47phox expression.	Quercetin	21-30	angiotensinogen	Homo sapiens	43-57
26778209-0	2016	The dietary flavonol quercetin ameliorates angiotensin II-induced redox signaling imbalance in a human umbilical vein endothelial cell model of endothelial dysfunction via ablation of p47phox expression.	Quercetin	21-30	neutrophil cytosolic factor 1	Homo sapiens	184-191
26778209-5	2016	Quercetin (3 muM, 8 h) prevented angiotensin II induced changes in nitric oxide and superoxide levels, but no effect upon nitric oxide or superoxide in control cells.	Quercetin	0-9	angiotensinogen	Homo sapiens	33-47
26778209-6	2016	The NADPH oxidase subunit p47(phox) was increased at the mRNA and protein levels in angiotensin II-treated cells (130 +- 14% of control, p&lt;0.05), which was ablated by quercetin co-treatment.	Quercetin	170-179	pleckstrin	Homo sapiens	26-29
26778209-6	2016	The NADPH oxidase subunit p47(phox) was increased at the mRNA and protein levels in angiotensin II-treated cells (130 +- 14% of control, p&lt;0.05), which was ablated by quercetin co-treatment.	Quercetin	170-179	angiotensinogen	Homo sapiens	84-98
26778209-8	2016	CONCLUSION: Physiologically obtainable quercetin concentrations are capable of ameliorating angiotensin II-induced endothelial nitric oxide and superoxide imbalance via protein kinase C-independent restoration of p47(phox) gene and protein expression.	Quercetin	39-48	angiotensinogen	Homo sapiens	92-106
26778209-8	2016	CONCLUSION: Physiologically obtainable quercetin concentrations are capable of ameliorating angiotensin II-induced endothelial nitric oxide and superoxide imbalance via protein kinase C-independent restoration of p47(phox) gene and protein expression.	Quercetin	39-48	pleckstrin	Homo sapiens	213-216
27025983-6	2016	Dimerization changed the chemical regioselectivity, substrate-binding affinity, and enzymatic activity of UGT1A1 and UGT1A9 in glucuronidation of quercetin.	Quercetin	146-155	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	106-112
27025983-6	2016	Dimerization changed the chemical regioselectivity, substrate-binding affinity, and enzymatic activity of UGT1A1 and UGT1A9 in glucuronidation of quercetin.	Quercetin	146-155	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	117-123
27025983-7	2016	These findings provide molecular insights into the consequences of homozygous and heterozygous UGT1A1 and UGT1A9 allozymes expression on quercetin glucuronidation.	Quercetin	137-146	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	95-101
27025983-7	2016	These findings provide molecular insights into the consequences of homozygous and heterozygous UGT1A1 and UGT1A9 allozymes expression on quercetin glucuronidation.	Quercetin	137-146	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	106-112
27065883-1	2016	We examined the inhibitory effects of three flavonolignans and their dehydro- derivatives, taxifolin and quercetin on the activity of the Na(+)/K(+)-ATPase (NKA).	Quercetin	105-114	tachykinin precursor 1	Homo sapiens	157-160
26902087-0	2016	Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin.	Quercetin	0-9	vitamin D receptor	Homo sapiens	34-52
26802551-0	2016	Quercetin derivative induces cell death in glioma cells by modulating NF-kappaB nuclear translocation and caspase-3 activation.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	70-79
26802551-0	2016	Quercetin derivative induces cell death in glioma cells by modulating NF-kappaB nuclear translocation and caspase-3 activation.	Quercetin	0-9	caspase 3	Homo sapiens	106-115
26902087-0	2016	Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin.	Quercetin	0-9	vitamin D receptor	Homo sapiens	54-57
26902087-0	2016	Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin.	Quercetin	0-9	vitamin D receptor	Homo sapiens	86-89
26902087-0	2016	Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin.	Quercetin	104-113	vitamin D receptor	Homo sapiens	34-52
26902087-0	2016	Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin.	Quercetin	104-113	vitamin D receptor	Homo sapiens	54-57
26902087-0	2016	Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin.	Quercetin	104-113	vitamin D receptor	Homo sapiens	86-89
26902087-3	2016	Quercetin is a widely distributed flavonoidin nature that is known to enhance transactivation of VDR target genes.	Quercetin	0-9	vitamin D receptor	Homo sapiens	97-100
26902087-4	2016	However, the detailed molecular mechanism underlying VDR activation by quercetin is not well understood.	Quercetin	71-80	vitamin D receptor	Homo sapiens	53-56
26902087-5	2016	We firstdemonstrated the interaction between quercetin and the VDR at the molecular level by using fluorecence quenching and saturation transfer difference (STD) NMR experiments.	Quercetin	45-54	vitamin D receptor	Homo sapiens	63-66
26902087-6	2016	The dissociation constant (Kd) of quercetin and the VDR was 21.15 +- 4.31 muM, and the mapping of quercetin subsites for VDR binding was performed using STD-NMR.	Quercetin	34-43	vitamin D receptor	Homo sapiens	52-55
26902087-6	2016	The dissociation constant (Kd) of quercetin and the VDR was 21.15 +- 4.31 muM, and the mapping of quercetin subsites for VDR binding was performed using STD-NMR.	Quercetin	34-43	vitamin D receptor	Homo sapiens	121-124
26902087-6	2016	The dissociation constant (Kd) of quercetin and the VDR was 21.15 +- 4.31 muM, and the mapping of quercetin subsites for VDR binding was performed using STD-NMR.	Quercetin	98-107	vitamin D receptor	Homo sapiens	52-55
26902087-6	2016	The dissociation constant (Kd) of quercetin and the VDR was 21.15 +- 4.31 muM, and the mapping of quercetin subsites for VDR binding was performed using STD-NMR.	Quercetin	98-107	vitamin D receptor	Homo sapiens	121-124
26902087-8	2016	Quercetin might serve as a scaffold for the development of VDR modulators with selective biological activities.	Quercetin	0-9	vitamin D receptor	Homo sapiens	59-62
27145632-0	2016	Quercetin accelerated cutaneous wound healing in rats by increasing levels of VEGF and TGF-beta1.	Quercetin	0-9	vascular endothelial growth factor A	Rattus norvegicus	78-82
25929518-12	2016	On the other hand, in the ciprofloxacin + quercetin group, SOD and CAT activities and GSH levels significantly increased with regard to the ciprofloxacin group.	Quercetin	42-51	catalase	Rattus norvegicus	67-70
27145632-0	2016	Quercetin accelerated cutaneous wound healing in rats by increasing levels of VEGF and TGF-beta1.	Quercetin	0-9	transforming growth factor, beta 1	Rattus norvegicus	87-96
27145632-7	2016	Vascular endothelial growth factor and transforming growth factor-beta1 expressions were significantly upregulated in quercetin-treated rats, whereas tumor necrosis factor-alpha level was markedly reduced.	Quercetin	118-127	myotrophin	Rattus norvegicus	21-34
27145632-7	2016	Vascular endothelial growth factor and transforming growth factor-beta1 expressions were significantly upregulated in quercetin-treated rats, whereas tumor necrosis factor-alpha level was markedly reduced.	Quercetin	118-127	myotrophin	Rattus norvegicus	52-65
27145632-7	2016	Vascular endothelial growth factor and transforming growth factor-beta1 expressions were significantly upregulated in quercetin-treated rats, whereas tumor necrosis factor-alpha level was markedly reduced.	Quercetin	118-127	tumor necrosis factor	Rattus norvegicus	150-177
27145632-8	2016	Interleukin- 10 levels and CD31 stained vessels were markedly higher on day 3 and on day 7, respectively, in quercetin-treated rats.	Quercetin	109-118	interleukin 10	Rattus norvegicus	0-15
27145632-8	2016	Interleukin- 10 levels and CD31 stained vessels were markedly higher on day 3 and on day 7, respectively, in quercetin-treated rats.	Quercetin	109-118	platelet and endothelial cell adhesion molecule 1	Rattus norvegicus	27-31
26923514-9	2016	The results showed that the activity of hepatic cholesterol 7alpha-hydroxylase, a critical enzyme in the conversion of cholesterol to bile acids, was significantly elevated by quercetin.	Quercetin	176-185	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	48-78
26627467-3	2016	METHODS AND RESULTS: Under normal conditions, quercetin impaired glucose and insulin tolerance and attenuated insulin-mediated phosphorylation of Akt substrate of 160 kDa (AS160) and TBC1D1 without affecting Akt activity in male Institute of Cancer Research (ICR) mice.	Quercetin	46-55	TBC1 domain family, member 4	Mus musculus	172-177
26627467-3	2016	METHODS AND RESULTS: Under normal conditions, quercetin impaired glucose and insulin tolerance and attenuated insulin-mediated phosphorylation of Akt substrate of 160 kDa (AS160) and TBC1D1 without affecting Akt activity in male Institute of Cancer Research (ICR) mice.	Quercetin	46-55	TBC1 domain family, member 1	Mus musculus	183-189
26627467-5	2016	In C2C12 cells, quercetin also decreased insulin-stimulated AS160 and TBC1D1 phosphorylation and glucose uptake in the absence of an inflammatory insult, whereas it improved the action of insulin under inflammatory conditions.	Quercetin	16-25	TBC1 domain family, member 4	Mus musculus	60-65
26627467-5	2016	In C2C12 cells, quercetin also decreased insulin-stimulated AS160 and TBC1D1 phosphorylation and glucose uptake in the absence of an inflammatory insult, whereas it improved the action of insulin under inflammatory conditions.	Quercetin	16-25	TBC1 domain family, member 1	Mus musculus	70-76
26457790-11	2016	Quercetin at 10, 25, 50 and 100 microg/mL inhibited TNF-alpha, but at 500 and 1,000 microg/mL stimulated cell growth.	Quercetin	0-9	tumor necrosis factor	Mus musculus	52-61
26627467-3	2016	METHODS AND RESULTS: Under normal conditions, quercetin impaired glucose and insulin tolerance and attenuated insulin-mediated phosphorylation of Akt substrate of 160 kDa (AS160) and TBC1D1 without affecting Akt activity in male Institute of Cancer Research (ICR) mice.	Quercetin	46-55	TBC1 domain family, member 4	Mus musculus	146-170
26676551-0	2016	Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo.	Quercetin	0-9	thrombospondin 1	Homo sapiens	40-56
26923514-10	2016	The expression of cholesterol 7alpha-hydroxylase, as well as liver X receptor alpha, an important transcription factor, was also increased at both mRNA and protein levels by quercetin.	Quercetin	174-183	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	18-48
26676551-0	2016	Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo.	Quercetin	0-9	proprotein convertase subtilisin/kexin type 1	Homo sapiens	106-110
26676551-6	2016	Thus, we explored the important role of TSP-1 upregulation in reducing angiogenesis and anti-prostate cancer effect of quercetin both in vitro and in vivo for the first time.	Quercetin	119-128	thrombospondin 1	Homo sapiens	40-45
26923514-10	2016	The expression of cholesterol 7alpha-hydroxylase, as well as liver X receptor alpha, an important transcription factor, was also increased at both mRNA and protein levels by quercetin.	Quercetin	174-183	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	61-83
26676551-8	2016	Therefore, quercetin could increase TSP-1 expression to inhibit angiogenesis resulting in antagonizing prostate cancer PC-3 cell and xenograft tumor growth.	Quercetin	11-20	thrombospondin 1	Homo sapiens	36-41
26676551-8	2016	Therefore, quercetin could increase TSP-1 expression to inhibit angiogenesis resulting in antagonizing prostate cancer PC-3 cell and xenograft tumor growth.	Quercetin	11-20	proprotein convertase subtilisin/kexin type 1	Homo sapiens	119-123
27041924-0	2016	Heat shock protein inhibitor, quercetin, as a novel adjuvant agent to improve radiofrequency ablation-induced tumor destruction and its molecular mechanism.	Quercetin	30-39	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-18
26454746-12	2016	Inhibition of early-stage autophagy by 3-MA or shRNA against Beclin1 attenuated the quercetin-induced cytotoxicity.	Quercetin	84-93	beclin 1	Homo sapiens	61-68
26680104-0	2016	Quercetin attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways.	Quercetin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	63-66
26680104-0	2016	Quercetin attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways.	Quercetin	0-9	mitogen activated protein kinase 14	Rattus norvegicus	71-74
26873426-8	2016	RESULTS: Quercetin intervention reduced plasma amylase level (P &lt; 0.001) in a dose-dependent manner, attenuated pancreatic histopathological damage (P &lt; 0.05), and reduced the mRNA and protein expression of NF-kB, IL-1beta, IL-6, TNFalpha (P &lt; 0.05) more significantly in HTG-related AP rats than in normal-lipid AP rats.	Quercetin	9-18	nuclear factor kappa B subunit 1	Rattus norvegicus	213-218
26873426-8	2016	RESULTS: Quercetin intervention reduced plasma amylase level (P &lt; 0.001) in a dose-dependent manner, attenuated pancreatic histopathological damage (P &lt; 0.05), and reduced the mRNA and protein expression of NF-kB, IL-1beta, IL-6, TNFalpha (P &lt; 0.05) more significantly in HTG-related AP rats than in normal-lipid AP rats.	Quercetin	9-18	interleukin 1 beta	Rattus norvegicus	220-228
26873426-8	2016	RESULTS: Quercetin intervention reduced plasma amylase level (P &lt; 0.001) in a dose-dependent manner, attenuated pancreatic histopathological damage (P &lt; 0.05), and reduced the mRNA and protein expression of NF-kB, IL-1beta, IL-6, TNFalpha (P &lt; 0.05) more significantly in HTG-related AP rats than in normal-lipid AP rats.	Quercetin	9-18	interleukin 6	Rattus norvegicus	230-234
26873426-8	2016	RESULTS: Quercetin intervention reduced plasma amylase level (P &lt; 0.001) in a dose-dependent manner, attenuated pancreatic histopathological damage (P &lt; 0.05), and reduced the mRNA and protein expression of NF-kB, IL-1beta, IL-6, TNFalpha (P &lt; 0.05) more significantly in HTG-related AP rats than in normal-lipid AP rats.	Quercetin	9-18	tumor necrosis factor	Rattus norvegicus	236-244
26873426-9	2016	Quercetin also down-regulated gene and protein expression levels of IRE1alpha, sXBP1, C/EBPalpha and C/EBPbeta in a dose-dependent manner.	Quercetin	0-9	CCAAT/enhancer binding protein alpha	Rattus norvegicus	86-96
26873426-9	2016	Quercetin also down-regulated gene and protein expression levels of IRE1alpha, sXBP1, C/EBPalpha and C/EBPbeta in a dose-dependent manner.	Quercetin	0-9	CCAAT/enhancer binding protein beta	Rattus norvegicus	101-110
26873426-10	2016	CONCLUSIONS: Quercetin attenuates early-stage inflammation in HTG-related AP, probably by reducing IRE1alpha, sXBP1, C/EBPalpha and C/EBPbeta expression.	Quercetin	13-22	CCAAT/enhancer binding protein alpha	Rattus norvegicus	117-127
26873426-10	2016	CONCLUSIONS: Quercetin attenuates early-stage inflammation in HTG-related AP, probably by reducing IRE1alpha, sXBP1, C/EBPalpha and C/EBPbeta expression.	Quercetin	13-22	CCAAT/enhancer binding protein beta	Rattus norvegicus	132-141
26927197-4	2016	In this study, we assess the binding interactions of four flavonoids (kaempferol, luteolin, quercetin, and resveratrol) with human serum albumin (HSA), the most abundant protein in the blood, and with glutathione S-transferase pi isoform-1 (GSTP1), an enzyme with well-characterized hydrophobic binding sites that plays an important role in detoxification of xenobiotics with reduced glutathione, using a novel Taylor dispersion surface plasmon resonance (SPR) technique.	Quercetin	92-101	glutathione S-transferase pi 1	Homo sapiens	201-239
26887929-3	2016	The present study aimed to target nitrosative stress using a naturally occurring Nos2 inhibitor, quercetin, to prevent NTDs in the embryos of diabetic mice.	Quercetin	97-106	nitric oxide synthase 2, inducible	Mus musculus	81-85
26887929-7	2016	Quercetin treatment decreased the levels of Nos2 expression, protein nitrosylation, and protein nitration, alleviating nitrosative stress.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	44-48
26565375-8	2016	The related natural flavonols, kaempferol and quercetin were less potent inhibitors of TRPC5.	Quercetin	46-55	transient receptor potential cation channel subfamily C member 5	Homo sapiens	87-92
27041924-6	2016	Most importantly, quercetin-induced cancer cell death required the presence of HSF1 in animal model.	Quercetin	18-27	heat shock transcription factor 1	Homo sapiens	79-83
27041924-7	2016	Furthermore, quercetin directly down-regulated expression of HSF1 in vitro, which our findings have revealed, required the activation of AP-1 signaling pathways by loss-of-function analysis using siRNA mediated targeting of c-Jun.	Quercetin	13-22	heat shock transcription factor 1	Homo sapiens	61-65
27041924-7	2016	Furthermore, quercetin directly down-regulated expression of HSF1 in vitro, which our findings have revealed, required the activation of AP-1 signaling pathways by loss-of-function analysis using siRNA mediated targeting of c-Jun.	Quercetin	13-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-141
27041924-7	2016	Furthermore, quercetin directly down-regulated expression of HSF1 in vitro, which our findings have revealed, required the activation of AP-1 signaling pathways by loss-of-function analysis using siRNA mediated targeting of c-Jun.	Quercetin	13-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	224-229
25691233-9	2016	The activities of uridine 5"-diphosphate-glucuronosyltransferase, phenolsulfotransferase and catechol-O-methyltransferase were induced by quercetin in a dose- and tissue-dependent manner in all animals.	Quercetin	138-147	catechol-O-methyltransferase	Rattus norvegicus	93-121
27305761-3	2016	This study was designed to investigate the efficacy of a nanoquercetin NQ; i.e., quercetin encapsulated in PAG (p-aminophenyl-1-thio-beta-D-galactopryranoside)-coated NIPAAM (N-isopropyl acrylamide) nanopolymer in liver compared with naked quercetin (Q) using a carbon tetrachloride (CCl4)-mediated liver cirrhosis model.	Quercetin	61-70	C-C motif chemokine ligand 4	Rattus norvegicus	284-288
27305761-3	2016	This study was designed to investigate the efficacy of a nanoquercetin NQ; i.e., quercetin encapsulated in PAG (p-aminophenyl-1-thio-beta-D-galactopryranoside)-coated NIPAAM (N-isopropyl acrylamide) nanopolymer in liver compared with naked quercetin (Q) using a carbon tetrachloride (CCl4)-mediated liver cirrhosis model.	Quercetin	81-90	C-C motif chemokine ligand 4	Rattus norvegicus	284-288
26800359-18	2016	Various vegetable polyphenols (luteolin, quercetin, apigenin) inhibited the hyperosmotic expression of bFGF, HB-EGF, and NFAT5 genes.	Quercetin	41-50	fibroblast growth factor 2	Homo sapiens	103-107
26267064-5	2016	Quercetin pretreatment significantly reduced the ConA-induced elevations in plasma aminotransferase concentrations and liver necrosis, as well as reducing serum concentrations of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, interferon-gamma, and interleukin-4.	Quercetin	0-9	interleukin 4	Mus musculus	267-280
26267064-6	2016	Quercetin pretreatment also reduced expression of high-mobility group box 1 protein (HMGB1) and toll-like receptor (TLR)-2 and TLR-4 messenger RNA (mRNA) and protein in liver tissues.	Quercetin	0-9	high mobility group box 1	Mus musculus	50-75
26267064-6	2016	Quercetin pretreatment also reduced expression of high-mobility group box 1 protein (HMGB1) and toll-like receptor (TLR)-2 and TLR-4 messenger RNA (mRNA) and protein in liver tissues.	Quercetin	0-9	high mobility group box 1	Mus musculus	85-90
26267064-6	2016	Quercetin pretreatment also reduced expression of high-mobility group box 1 protein (HMGB1) and toll-like receptor (TLR)-2 and TLR-4 messenger RNA (mRNA) and protein in liver tissues.	Quercetin	0-9	toll-like receptor 2	Mus musculus	96-122
26267064-6	2016	Quercetin pretreatment also reduced expression of high-mobility group box 1 protein (HMGB1) and toll-like receptor (TLR)-2 and TLR-4 messenger RNA (mRNA) and protein in liver tissues.	Quercetin	0-9	toll-like receptor 4	Mus musculus	127-132
26267064-7	2016	Quercetin pretreatment significantly inhibited degradation of inhibitory kappa B alpha and modulated ConA-induced nuclear translocation in the liver of nuclear factor kappa B (NF-kappaB) p65.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	152-174
26267064-7	2016	Quercetin pretreatment significantly inhibited degradation of inhibitory kappa B alpha and modulated ConA-induced nuclear translocation in the liver of nuclear factor kappa B (NF-kappaB) p65.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	176-185
26267064-7	2016	Quercetin pretreatment significantly inhibited degradation of inhibitory kappa B alpha and modulated ConA-induced nuclear translocation in the liver of nuclear factor kappa B (NF-kappaB) p65.	Quercetin	0-9	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	187-190
26267064-8	2016	These results demonstrate that quercetin protects against ConA-mediated hepatitis in mice by attenuating the HMGB1-TLRs-NF-kappaB signaling pathway.	Quercetin	31-40	high mobility group box 1	Mus musculus	109-114
26267064-8	2016	These results demonstrate that quercetin protects against ConA-mediated hepatitis in mice by attenuating the HMGB1-TLRs-NF-kappaB signaling pathway.	Quercetin	31-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
26499876-3	2016	Supplementation with quercetin suppressed the increase in the number of macrophages, the decrease in the ratio of CD4(+) to CD8(+) T cells in EAT, and the elevation of plasma leptin and tumor necrosis factor alpha levels in mice fed the Western diet.	Quercetin	21-30	CD4 antigen	Mus musculus	114-117
26499876-3	2016	Supplementation with quercetin suppressed the increase in the number of macrophages, the decrease in the ratio of CD4(+) to CD8(+) T cells in EAT, and the elevation of plasma leptin and tumor necrosis factor alpha levels in mice fed the Western diet.	Quercetin	21-30	tumor necrosis factor	Mus musculus	186-213
26267064-0	2016	Quercetin Protects Mice from ConA-Induced Hepatitis by Inhibiting HMGB1-TLR Expression and Down-Regulating the Nuclear Factor Kappa B Pathway.	Quercetin	0-9	high mobility group box 1	Mus musculus	66-71
26267064-0	2016	Quercetin Protects Mice from ConA-Induced Hepatitis by Inhibiting HMGB1-TLR Expression and Down-Regulating the Nuclear Factor Kappa B Pathway.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	111-133
26267064-5	2016	Quercetin pretreatment significantly reduced the ConA-induced elevations in plasma aminotransferase concentrations and liver necrosis, as well as reducing serum concentrations of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, interferon-gamma, and interleukin-4.	Quercetin	0-9	tumor necrosis factor	Mus musculus	210-243
26267064-5	2016	Quercetin pretreatment significantly reduced the ConA-induced elevations in plasma aminotransferase concentrations and liver necrosis, as well as reducing serum concentrations of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, interferon-gamma, and interleukin-4.	Quercetin	0-9	interferon gamma	Mus musculus	245-261
27433585-0	2016	Bovine Serum Albumin Nanoparticles Containing Quercetin: Characterization and Antioxidant Activity.	Quercetin	46-55	albumin	Homo sapiens	7-20
27433585-4	2016	In this study, bovine serum albumin (BSA) nanoparticles containing quercetin were developed by desolvation technique, characterized the mean particle size, polydispersity, zeta potential, encapsulation efficiency, physical state of drug in nanoparticles and drug release profile as well as their antioxidant activity was evaluated.	Quercetin	67-76	albumin	Homo sapiens	22-35
26800359-18	2016	Various vegetable polyphenols (luteolin, quercetin, apigenin) inhibited the hyperosmotic expression of bFGF, HB-EGF, and NFAT5 genes.	Quercetin	41-50	heparin binding EGF like growth factor	Homo sapiens	109-115
26800359-18	2016	Various vegetable polyphenols (luteolin, quercetin, apigenin) inhibited the hyperosmotic expression of bFGF, HB-EGF, and NFAT5 genes.	Quercetin	41-50	nuclear factor of activated T cells 5	Homo sapiens	121-126
27336168-0	2016	Quercetin Stimulates Insulin Secretion and Reduces the Viability of Rat INS-1 Beta-Cells.	Quercetin	0-9	insulin 1	Rattus norvegicus	72-77
26775807-3	2016	Here, we identified that isorhamnetin, a naturally occurring compound in fruits and vegetables and the metabolite of quercetin, is a novel antagonist of PPARgamma.	Quercetin	117-126	peroxisome proliferator activated receptor gamma	Homo sapiens	153-162
26752173-13	2016	Hepatic mRNA expression of tumor necrosis factor was higher after quercetin feeding and expression of C-reactive protein was higher after formula feeding.	Quercetin	66-75	tumor necrosis factor	Bos taurus	27-48
26742072-6	2016	Moreover, quercetin blocked chronic ethanol-induced mitophagy suppression as denoted by mitophagosomes-lysosome fusion and mitophagy-related regulator elements, including LC3II, Parkin, p62 and voltage-dependent anion channel 1 (VDAC1), paralleling with increased FoxO3a nuclear translocation.	Quercetin	10-19	nucleoporin 62	Mus musculus	186-189
26742072-6	2016	Moreover, quercetin blocked chronic ethanol-induced mitophagy suppression as denoted by mitophagosomes-lysosome fusion and mitophagy-related regulator elements, including LC3II, Parkin, p62 and voltage-dependent anion channel 1 (VDAC1), paralleling with increased FoxO3a nuclear translocation.	Quercetin	10-19	voltage-dependent anion channel 1	Mus musculus	194-227
26742072-6	2016	Moreover, quercetin blocked chronic ethanol-induced mitophagy suppression as denoted by mitophagosomes-lysosome fusion and mitophagy-related regulator elements, including LC3II, Parkin, p62 and voltage-dependent anion channel 1 (VDAC1), paralleling with increased FoxO3a nuclear translocation.	Quercetin	10-19	voltage-dependent anion channel 1	Mus musculus	229-234
26742072-6	2016	Moreover, quercetin blocked chronic ethanol-induced mitophagy suppression as denoted by mitophagosomes-lysosome fusion and mitophagy-related regulator elements, including LC3II, Parkin, p62 and voltage-dependent anion channel 1 (VDAC1), paralleling with increased FoxO3a nuclear translocation.	Quercetin	10-19	forkhead box O3	Mus musculus	264-270
26742072-7	2016	AMP-activated protein kinase (AMPK) and extracellular signal regulated kinase 2 (ERK2), instead of AKT and Sirtuin 1, were involved in quercetin-mediated mitophagy activation.	Quercetin	135-144	mitogen-activated protein kinase 1	Mus musculus	40-79
26742072-7	2016	AMP-activated protein kinase (AMPK) and extracellular signal regulated kinase 2 (ERK2), instead of AKT and Sirtuin 1, were involved in quercetin-mediated mitophagy activation.	Quercetin	135-144	mitogen-activated protein kinase 1	Mus musculus	81-85
26742072-7	2016	AMP-activated protein kinase (AMPK) and extracellular signal regulated kinase 2 (ERK2), instead of AKT and Sirtuin 1, were involved in quercetin-mediated mitophagy activation.	Quercetin	135-144	thymoma viral proto-oncogene 1	Mus musculus	99-102
26742072-7	2016	AMP-activated protein kinase (AMPK) and extracellular signal regulated kinase 2 (ERK2), instead of AKT and Sirtuin 1, were involved in quercetin-mediated mitophagy activation.	Quercetin	135-144	sirtuin 1	Mus musculus	107-116
26942188-0	2016	Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes.	Quercetin	39-48	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56
26942188-4	2016	Both, ginger phenylpropanoids and quercetin, significantly increased the level of Nrf2 activity.	Quercetin	34-43	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
26942188-7	2016	Thus, while both ginger phenylpropanoids and quercetin have the property of increasing the level of Nrf2 both in HaCaT and in BJ cells, their effects on its downstream signalling were mediated only in BJ cells.	Quercetin	45-54	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
27186419-0	2016	Quercetin induces bladder cancer cells apoptosis by activation of AMPK signaling pathway.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	66-70
27186419-10	2016	We are the first to show that quercetin displays potent inhibition on bladder cancer cells via activation of AMPK pathway.	Quercetin	30-39	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	109-113
26476923-3	2016	In this work, the inhibitory effects of dexamethasone and quercetin on LPS-CD14 receptor binding in RAW264.7 macrophages was probed by LPS-functionalized tips for the first time.	Quercetin	58-67	CD14 antigen	Mus musculus	75-79
26476923-4	2016	Both dexamethasone and quercetin were found to inhibit LPS-induced NO production, iNOS expression, IkappaBalpha phosphorylation, and IKKalpha/beta phosphorylation in RAW264.7 macrophages.	Quercetin	23-32	nitric oxide synthase 2, inducible	Mus musculus	82-86
26476923-4	2016	Both dexamethasone and quercetin were found to inhibit LPS-induced NO production, iNOS expression, IkappaBalpha phosphorylation, and IKKalpha/beta phosphorylation in RAW264.7 macrophages.	Quercetin	23-32	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	99-111
26476923-4	2016	Both dexamethasone and quercetin were found to inhibit LPS-induced NO production, iNOS expression, IkappaBalpha phosphorylation, and IKKalpha/beta phosphorylation in RAW264.7 macrophages.	Quercetin	23-32	conserved helix-loop-helix ubiquitous kinase	Mus musculus	133-141
26476923-6	2016	The binding of LPS and its receptor in RAW264.7 macrophages was determined by LPS-functionalized AFM tips, which demonstrated that the binding force and binding probability between LPS and CD14 receptor on the surface of RAW264.7 macrophages were also inhibited by dexamethasone or quercetin treatment.	Quercetin	282-291	CD14 antigen	Mus musculus	189-193
27336168-18	2016	Long term application of quercetin inhibits cell proliferation and induces apoptosis, most likely by inhibition of PI3K/Akt signaling.	Quercetin	25-34	AKT serine/threonine kinase 1	Rattus norvegicus	120-123
27336168-8	2016	Quercetin (50 microM) significantly increased the percentage of Annexin-V+ cells within 48 hrs.	Quercetin	0-9	annexin A5	Rattus norvegicus	64-73
27336168-10	2016	Within 2 hrs, quercetin significantly decreased basal- and insulin-stimulated Akt(T308) phosphorylation and increased Erk1/2 phosphorylation, without affecting P-Akt(S473) abundance.	Quercetin	14-23	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
27336168-10	2016	Within 2 hrs, quercetin significantly decreased basal- and insulin-stimulated Akt(T308) phosphorylation and increased Erk1/2 phosphorylation, without affecting P-Akt(S473) abundance.	Quercetin	14-23	mitogen activated protein kinase 3	Rattus norvegicus	118-124
26875909-1	2016	OBJECTIVE: Quercetin, a plant flavonoid with potent antioxidant action, has been shown to be ameliorative against different types of liver insults, including D-Galactosamine/Lipopolysaccharide (D-GalN/LPS).	Quercetin	11-20	galanin and GMAP prepropeptide	Rattus norvegicus	196-200
26607666-6	2016	Quercetin and luteolin were demonstrated to have dual functionality with respect to SIRT6 activity; namely, they inhibited SIRT6 activity with IC50 values of 24 and 2 mum, respectively, and stimulated SIRT6 activity more than sixfold (EC50 values of 990 and 270 mum, respectively).	Quercetin	0-9	sirtuin 6	Homo sapiens	123-128
26607666-6	2016	Quercetin and luteolin were demonstrated to have dual functionality with respect to SIRT6 activity; namely, they inhibited SIRT6 activity with IC50 values of 24 and 2 mum, respectively, and stimulated SIRT6 activity more than sixfold (EC50 values of 990 and 270 mum, respectively).	Quercetin	0-9	sirtuin 6	Homo sapiens	123-128
24937381-2	2016	The present work is aimed to enhance the bioavailability of etoposide by co-administering it with quercetin (a P-gp inhibitor) in dual-loaded polymeric nanoparticle formulation.	Quercetin	98-107	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	111-115
26607666-4	2016	In this study, we investigated whether a series of N-acylethanolamines (NAEs), quercetin, and luteolin could regulate SIRT6 activity.	Quercetin	79-88	sirtuin 6	Homo sapiens	118-123
26607666-6	2016	Quercetin and luteolin were demonstrated to have dual functionality with respect to SIRT6 activity; namely, they inhibited SIRT6 activity with IC50 values of 24 and 2 mum, respectively, and stimulated SIRT6 activity more than sixfold (EC50 values of 990 and 270 mum, respectively).	Quercetin	0-9	sirtuin 6	Homo sapiens	84-89
26844571-4	2016	Among such compounds, flavonoids found in natural sources, like quercetin, genistein, epigallocatechins, resveratrol, have been proposed as AMPK activators.	Quercetin	64-73	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	140-144
26875909-7	2016	Conversely, quercetin and SRT1720 pretreatments upregulated SIRT1 expression and decreased the levels of the aforementioned markers.	Quercetin	12-21	sirtuin 1	Rattus norvegicus	60-65
26875909-8	2016	Quercetin had more profound effect on SIRT1 expression than SRT1720.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	38-43
26875909-9	2016	Moreover, quercetin was more efficacious than SRT1720 in combatting the cytotoxic effects of D-GalN/LPS, as evidenced by lower markers of liver injury.	Quercetin	10-19	galanin and GMAP prepropeptide	Rattus norvegicus	95-99
27034691-9	2016	Pretreatment with Gelam honey and quercetin reduced the expression of phosphorylated JNK, IKK-beta, and IRS-1, thereby significantly reducing the expression of proinflammatory cytokines like TNF-alpha, IL-6, and IL-1beta (p &lt; 0.05).	Quercetin	34-43	insulin receptor substrate 1	Mesocricetus auratus	104-109
26875909-10	2016	CONCLUSIONS: These results strongly suggest the involvement of SIRT1 in the cytoprotective effects of quercetin and SRT1720 against D-GalN/LPS-induced hepatotoxicity.	Quercetin	102-111	sirtuin 1	Rattus norvegicus	63-68
26875909-10	2016	CONCLUSIONS: These results strongly suggest the involvement of SIRT1 in the cytoprotective effects of quercetin and SRT1720 against D-GalN/LPS-induced hepatotoxicity.	Quercetin	102-111	galanin and GMAP prepropeptide	Rattus norvegicus	134-138
27034691-9	2016	Pretreatment with Gelam honey and quercetin reduced the expression of phosphorylated JNK, IKK-beta, and IRS-1, thereby significantly reducing the expression of proinflammatory cytokines like TNF-alpha, IL-6, and IL-1beta (p &lt; 0.05).	Quercetin	34-43	interleukin-6	Mesocricetus auratus	202-206
29537230-0	2016	KORVITIN REDUCES THE HIGH MAINTENANCE OF MYELOPEROXIDASE IN PLASMA OF BLOOD OF PATIENTS WITH THE ACUTE INFARCT OF MYOCARDIUM.	Quercetin	0-8	myeloperoxidase	Homo sapiens	41-56
27034691-9	2016	Pretreatment with Gelam honey and quercetin reduced the expression of phosphorylated JNK, IKK-beta, and IRS-1, thereby significantly reducing the expression of proinflammatory cytokines like TNF-alpha, IL-6, and IL-1beta (p &lt; 0.05).	Quercetin	34-43	interleukin-1 beta	Mesocricetus auratus	212-220
27034691-11	2016	In conclusion, our data suggest the potential use of the extract from Gelam honey and quercetin in modulating the inflammation induced insulin signaling pathways.	Quercetin	86-95	insulin	Mesocricetus auratus	135-142
29537230-1	2016	We studied the content of myeloperoxidase in plasma of blood, which is a new additional marker of the metabolic activity of phagocytes and the activity of inflammation in patientes with the acute infarct of myocardium and possibility of its correction of Korvitin.	Quercetin	255-263	myeloperoxidase	Homo sapiens	26-41
29537230-3	2016	In patients accepting standard treatment (without application of Korvitin), the content of myeloperoxidase was unchanged during 7 days of treatment.	Quercetin	65-73	myeloperoxidase	Homo sapiens	91-106
29537230-4	2016	It patients administered korvitin, the action of this preparation depended on the initial level of myeloperoxidase.	Quercetin	25-33	myeloperoxidase	Homo sapiens	99-114
26709124-0	2016	Suppressive Activity of Quercetin on Periostin Functions In Vitro.	Quercetin	24-33	periostin	Homo sapiens	37-46
26709124-2	2016	Although oral administration of quercetin to patients with AR can favorably modify the clinical condition of this disease, the influence of quercetin on periostin functions is not well understood.	Quercetin	140-149	periostin	Homo sapiens	153-162
26709124-3	2016	The present study was, therefore, undertaken to examine the influence of quercetin on the production of both periostin and periostin-induced eosinophil chemoattractants from human nasal epithelial cells (HNEpC) in vitro.	Quercetin	73-82	periostin	Homo sapiens	109-118
26709124-3	2016	The present study was, therefore, undertaken to examine the influence of quercetin on the production of both periostin and periostin-induced eosinophil chemoattractants from human nasal epithelial cells (HNEpC) in vitro.	Quercetin	73-82	periostin	Homo sapiens	123-132
26709124-5	2016	Addition of 4.0 muM quercetin into cell cultures suppressed periostin production from HNEpC that was induced by IL-4 stimulation through inhibitation of signal transducer and activator of transcription 6 (STAT6) activation.	Quercetin	20-29	periostin	Homo sapiens	60-69
26709124-5	2016	Addition of 4.0 muM quercetin into cell cultures suppressed periostin production from HNEpC that was induced by IL-4 stimulation through inhibitation of signal transducer and activator of transcription 6 (STAT6) activation.	Quercetin	20-29	interleukin 4	Homo sapiens	112-116
26709124-5	2016	Addition of 4.0 muM quercetin into cell cultures suppressed periostin production from HNEpC that was induced by IL-4 stimulation through inhibitation of signal transducer and activator of transcription 6 (STAT6) activation.	Quercetin	20-29	signal transducer and activator of transcription 6	Homo sapiens	153-203
26709124-5	2016	Addition of 4.0 muM quercetin into cell cultures suppressed periostin production from HNEpC that was induced by IL-4 stimulation through inhibitation of signal transducer and activator of transcription 6 (STAT6) activation.	Quercetin	20-29	signal transducer and activator of transcription 6	Homo sapiens	205-210
26709124-6	2016	We then examined whether quercetin could inhibit production of the periostin-induced eosinophil chemoattractants, regulated on activation, normal T-cell expressed and secreted (RANTES) and eotaxin, from HNEpC.	Quercetin	25-34	periostin	Homo sapiens	67-76
26709124-6	2016	We then examined whether quercetin could inhibit production of the periostin-induced eosinophil chemoattractants, regulated on activation, normal T-cell expressed and secreted (RANTES) and eotaxin, from HNEpC.	Quercetin	25-34	C-C motif chemokine ligand 11	Homo sapiens	189-196
26709124-8	2016	Treatment of HNEpC with quercetin at a concentration of 4.0 muM suppressed the ability of cells to produce RANTES and eotaxin.	Quercetin	24-33	C-C motif chemokine ligand 5	Homo sapiens	107-113
26709124-8	2016	Treatment of HNEpC with quercetin at a concentration of 4.0 muM suppressed the ability of cells to produce RANTES and eotaxin.	Quercetin	24-33	C-C motif chemokine ligand 11	Homo sapiens	118-125
26709124-10	2016	These results strongly suggest that quercetin suppresses the production of both periostin and periostin-induced eosinophil chemoattractants from HNEpC and results in improvement of the clinical condition of AR.	Quercetin	36-45	periostin	Homo sapiens	80-89
26709124-10	2016	These results strongly suggest that quercetin suppresses the production of both periostin and periostin-induced eosinophil chemoattractants from HNEpC and results in improvement of the clinical condition of AR.	Quercetin	36-45	periostin	Homo sapiens	94-103
27975068-0	2016	Quercetin Isolated from Toona sinensis Leaves Attenuates Hyperglycemia and Protects Hepatocytes in High-Carbohydrate/High-Fat Diet and Alloxan Induced Experimental Diabetic Mice.	Quercetin	0-9	CD36 molecule	Mus musculus	122-125
26507542-5	2016	Quercetin prevented the decrease in nuclear translocation of Nrf2, a key regulator of the antioxidant response, and the increase in reactive oxygen species levels induced by INDO by inhibiting the enhancement of NADPH oxidase and xanthine oxidase activities as well as the reduction in superoxide dismutase and glutathione peroxidase activities in gastric and ileal tissues.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
27310654-8	2016	MDA levels reduced and SOD, CAT and GPx activities increased significantly in Quercetin + Ischemia reperfusion group.	Quercetin	78-87	catalase	Rattus norvegicus	28-31
26414235-7	2016	The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway.	Quercetin	114-123	BCL2 associated X, apoptosis regulator	Rattus norvegicus	138-141
26414235-7	2016	The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway.	Quercetin	114-123	BCL2, apoptosis regulator	Rattus norvegicus	142-147
26414235-7	2016	The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway.	Quercetin	114-123	AKT serine/threonine kinase 1	Rattus norvegicus	171-174
26414235-7	2016	The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway.	Quercetin	114-123	AKT serine/threonine kinase 1	Rattus norvegicus	302-305
26414235-7	2016	The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway.	Quercetin	203-212	BCL2 associated X, apoptosis regulator	Rattus norvegicus	138-141
26414235-7	2016	The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway.	Quercetin	203-212	AKT serine/threonine kinase 1	Rattus norvegicus	171-174
27057371-0	2016	Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells.	Quercetin	0-9	centromere protein J	Homo sapiens	66-70
27057371-6	2016	Furthermore, it was demonstrated that quercetin induces cancer cell apoptosis by downregulating the levels of Hsp90.	Quercetin	38-47	heat shock protein 90 alpha family class A member 1	Homo sapiens	110-115
27057371-7	2016	In conclusion, we have shown that quercetin induces downregulation of Hsp90 expression that may be involved in the decrease of chymotrypsin-like proteasome activity which, in order, induces inhibition of growth and causes cell death in thyroid cancer cells.	Quercetin	34-43	heat shock protein 90 alpha family class A member 1	Homo sapiens	70-75
27057371-8	2016	Thus, quercetin appears to be a promising candidate drug for Hsp90 downregulation and apoptosis of thyroid cancer cells.	Quercetin	6-15	heat shock protein 90 alpha family class A member 1	Homo sapiens	61-66
26478390-0	2016	Sol-gel synthesis and characterization of SiO2/PCL hybrid materials containing quercetin as new materials for antioxidant implants.	Quercetin	79-88	PHD finger protein 1	Homo sapiens	47-50
26623679-6	2016	The minimal quercetin concentration inducing NQO1, however, was 100-fold higher than that which disrupted mitosis.	Quercetin	12-21	NAD(P)H dehydrogenase, quinone 1	Mus musculus	45-49
26414235-0	2016	Protection afforded by quercetin against H2O2-induced apoptosis on PC12 cells via activating PI3K/Akt signal pathway.	Quercetin	23-32	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
26414235-4	2016	It finally turned out that quercetin might protect PC12 cells against the negative effect of H(2)O(2) by decreasing of LDH release, ROS concentration and MDA level and regaining the GSH-Px and SOD activities.	Quercetin	27-36	glutathione peroxidase 1	Rattus norvegicus	182-188
26507542-6	2016	Quercetin also prevented INDO-induced ICAM-1 and P-selectin expressions and the increase of myeloperoxidase activity in gastric and ileal tissues and NF-kappaB activation and IL-8 production in Caco-2 cells.	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	38-44
26507542-6	2016	Quercetin also prevented INDO-induced ICAM-1 and P-selectin expressions and the increase of myeloperoxidase activity in gastric and ileal tissues and NF-kappaB activation and IL-8 production in Caco-2 cells.	Quercetin	0-9	selectin P	Homo sapiens	49-59
26507542-6	2016	Quercetin also prevented INDO-induced ICAM-1 and P-selectin expressions and the increase of myeloperoxidase activity in gastric and ileal tissues and NF-kappaB activation and IL-8 production in Caco-2 cells.	Quercetin	0-9	myeloperoxidase	Homo sapiens	92-107
26507542-6	2016	Quercetin also prevented INDO-induced ICAM-1 and P-selectin expressions and the increase of myeloperoxidase activity in gastric and ileal tissues and NF-kappaB activation and IL-8 production in Caco-2 cells.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
26507542-8	2016	The protective effects of quercetin observed in the gastric and ileal mucosa of rats as well as in Caco-2 cells relied on the ability of this flavonol to prevent NF-kappaB activation and increase Nrf2 translocation.	Quercetin	26-35	NFE2 like bZIP transcription factor 2	Homo sapiens	196-200
27433029-10	2016	CP and its polyphenolic active components (primarily caffeic acid phenethyl ester and quercetin) had strong inhibitive effects against NF-kappaB activation and increased the transcriptional activity of Nrf2-ARE.	Quercetin	86-95	NFE2 like bZIP transcription factor 2	Bos taurus	202-206
26648539-0	2016	Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells.	Quercetin	57-66	heat shock protein family B (small) member 1	Homo sapiens	15-20
26648539-8	2016	The Notch/AKT/mTOR signaling pathway is important in tumor aggressiveness; quercetin plus shHSP27 significantly decreased Notch 1 expression and the phosphorylation levels of the downstream signaling proteins AKT and mTOR.	Quercetin	75-84	mechanistic target of rapamycin kinase	Homo sapiens	217-221
26648539-3	2016	The present study investigated the effects of small hairpin (sh)RNA-mediated HSP27 knockdown on the anti-cancer effects of quercetin in U937 human leukemia cells.	Quercetin	123-132	heat shock protein family B (small) member 1	Homo sapiens	77-82
26648539-10	2016	Therefore, these findings collectively suggested that suppression of HSP27 expression amplified the anti-cancer effects of quercetin in U937 human leukemia cells, and that quercetin in combination with shHSP27 represents a promising therapeutic strategy for human leukemia.	Quercetin	123-132	heat shock protein family B (small) member 1	Homo sapiens	69-74
26648539-5	2016	The results showed that shHSP27 and quercetin synergistically inhibited U937 cell proliferation and induced apoptosis by decreasing the Bcl2-to-Bax ratio.	Quercetin	36-45	BCL2 apoptosis regulator	Homo sapiens	136-140
26648539-5	2016	The results showed that shHSP27 and quercetin synergistically inhibited U937 cell proliferation and induced apoptosis by decreasing the Bcl2-to-Bax ratio.	Quercetin	36-45	BCL2 associated X, apoptosis regulator	Homo sapiens	144-147
26648539-7	2016	Compared with shHSP27 or quercetin alone, shHSP27 plus quercetin markedly decreased the protein expression of cyclinD1 and thus blocked the cell cycle at G1 phase.	Quercetin	25-34	cyclin D1	Homo sapiens	110-118
26648539-7	2016	Compared with shHSP27 or quercetin alone, shHSP27 plus quercetin markedly decreased the protein expression of cyclinD1 and thus blocked the cell cycle at G1 phase.	Quercetin	55-64	cyclin D1	Homo sapiens	110-118
26648539-8	2016	The Notch/AKT/mTOR signaling pathway is important in tumor aggressiveness; quercetin plus shHSP27 significantly decreased Notch 1 expression and the phosphorylation levels of the downstream signaling proteins AKT and mTOR.	Quercetin	75-84	AKT serine/threonine kinase 1	Homo sapiens	10-13
26648539-8	2016	The Notch/AKT/mTOR signaling pathway is important in tumor aggressiveness; quercetin plus shHSP27 significantly decreased Notch 1 expression and the phosphorylation levels of the downstream signaling proteins AKT and mTOR.	Quercetin	75-84	mechanistic target of rapamycin kinase	Homo sapiens	14-18
26648539-8	2016	The Notch/AKT/mTOR signaling pathway is important in tumor aggressiveness; quercetin plus shHSP27 significantly decreased Notch 1 expression and the phosphorylation levels of the downstream signaling proteins AKT and mTOR.	Quercetin	75-84	notch receptor 1	Homo sapiens	122-129
25774442-0	2016	Naringenin and quercetin--potential anti-HCV agents for NS2 protease targets.	Quercetin	15-24	NS2	Homo sapiens	56-59
26648539-8	2016	The Notch/AKT/mTOR signaling pathway is important in tumor aggressiveness; quercetin plus shHSP27 significantly decreased Notch 1 expression and the phosphorylation levels of the downstream signaling proteins AKT and mTOR.	Quercetin	75-84	AKT serine/threonine kinase 1	Homo sapiens	209-212
25774442-4	2016	Among the molecules tested for docking study, naringenin and quercetin revealed minimum binding energy of - 7.97 and - 7.95 kcal/mol with NS2 protease.	Quercetin	61-70	NS2	Homo sapiens	138-141
26943884-3	2016	Flavonoids, like quercetin, are GLUT-1 competitive inhibitors and may be considered as potential therapeutic agents for PLTs.	Quercetin	17-26	solute carrier family 2 member 1	Homo sapiens	32-38
26943884-6	2016	It was found that in all the cell lines, quercetin induced inhibition of the metabolic activity and cell death by apoptosis, followed by increase in BAX/BCL-2 ratio.	Quercetin	41-50	BCL2 associated X, apoptosis regulator	Homo sapiens	149-152
26943884-6	2016	It was found that in all the cell lines, quercetin induced inhibition of the metabolic activity and cell death by apoptosis, followed by increase in BAX/BCL-2 ratio.	Quercetin	41-50	BCL2 apoptosis regulator	Homo sapiens	153-158
26943884-9	2016	Incubation with quercetin induced an increase in GLUT-1 membrane expression and a consequent reduction in the cytoplasmic fraction, observed as a decrease in (18)F-FDG uptake, indicating a GLUT-1 competitive inhibition.	Quercetin	16-25	solute carrier family 2 member 1	Homo sapiens	49-55
26943884-9	2016	Incubation with quercetin induced an increase in GLUT-1 membrane expression and a consequent reduction in the cytoplasmic fraction, observed as a decrease in (18)F-FDG uptake, indicating a GLUT-1 competitive inhibition.	Quercetin	16-25	solute carrier family 2 member 1	Homo sapiens	189-195
26943884-11	2016	Thus, the use of quercetin seems to be a promising approach for PLTs through GLUT-1 competitive inhibition.	Quercetin	17-26	solute carrier family 2 member 1	Homo sapiens	77-83
26904161-7	2016	In addition, quercetin has been shown to activate sirtuins (SIRT1), to induce autophagy, and to act as a phytoestrogen, all mechanisms by which quercetin may provide its neuroprotection.	Quercetin	13-22	sirtuin 1	Homo sapiens	60-65
26881018-3	2016	We asked whether phenolic compounds (resveratrol, pterostilbene, quercetin, and caffeic acid) behave as MAO and SSAO inhibitors.	Quercetin	65-74	amine oxidase copper containing 2	Homo sapiens	112-116
25858254-8	2016	RESULTS: Our results showed that mulberrin, scutellarin, quercetin, and glycyrrhetinic acid were strong inhibitors of OATP2B1-mediate E3S uptake with IC50 values being 1.8, 2.0, 7.5, and 13.0 muM, which were comparable with their plasma concentrations in clinical trials.	Quercetin	57-66	solute carrier organic anion transporter family member 2B1	Homo sapiens	118-125
27504150-6	2016	Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation).	Quercetin	13-22	mitogen-activated protein kinase 8	Mus musculus	133-154
27504150-6	2016	Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation).	Quercetin	13-22	mitogen-activated protein kinase 8	Mus musculus	156-159
27504150-6	2016	Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation).	Quercetin	13-22	activating transcription factor 6	Mus musculus	162-195
27504150-6	2016	Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation).	Quercetin	13-22	activating transcription factor 6	Mus musculus	197-201
27504150-6	2016	Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation).	Quercetin	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	218-227
27504150-6	2016	Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation).	Quercetin	13-22	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	229-232
27504150-6	2016	Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation).	Quercetin	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	237-240
27504150-8	2016	SP600125 (JNK inhibitor), AEBSF (ATF6 inhibitor), and especially PDTC (NF-kappaB inhibitor) enhanced the quercetin-induced protection against Tg stimulation.	Quercetin	105-114	mitogen-activated protein kinase 8	Mus musculus	10-13
27504150-8	2016	SP600125 (JNK inhibitor), AEBSF (ATF6 inhibitor), and especially PDTC (NF-kappaB inhibitor) enhanced the quercetin-induced protection against Tg stimulation.	Quercetin	105-114	activating transcription factor 6	Mus musculus	33-37
27504150-8	2016	SP600125 (JNK inhibitor), AEBSF (ATF6 inhibitor), and especially PDTC (NF-kappaB inhibitor) enhanced the quercetin-induced protection against Tg stimulation.	Quercetin	105-114	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
26459667-11	2016	Quercetin also demonstrated PI3 kinase inhibition in a docking study and decreased CYP17A1 gene expression.	Quercetin	0-9	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	83-90
26459667-12	2016	DISCUSSION AND CONCLUSION: Thus, we can conclude that quercetin may have beneficial effect in PCOS by virtue of inhibition of PI3K which attributes to a decrease in the expression of CYP17A1 gene, having a key role in steroidogenesis.	Quercetin	54-63	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	183-190
27504150-0	2016	Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress and Inflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinase and Nuclear Factor-Kappa B.	Quercetin	27-36	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	125-150
27504150-5	2016	Intense exercise and thapsigargin- (Tg-) induced ERS (glucose-regulated protein 78, GRP78) and inflammatory cytokines levels (IL-6 and TNF-alpha) were decreased with quercetin.	Quercetin	166-175	heat shock protein 5	Mus musculus	84-89
27504150-5	2016	Intense exercise and thapsigargin- (Tg-) induced ERS (glucose-regulated protein 78, GRP78) and inflammatory cytokines levels (IL-6 and TNF-alpha) were decreased with quercetin.	Quercetin	166-175	interleukin 6	Mus musculus	126-130
27504150-5	2016	Intense exercise and thapsigargin- (Tg-) induced ERS (glucose-regulated protein 78, GRP78) and inflammatory cytokines levels (IL-6 and TNF-alpha) were decreased with quercetin.	Quercetin	166-175	tumor necrosis factor	Mus musculus	135-144
27504150-6	2016	Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation).	Quercetin	13-22	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	35-60
26052623-8	2016	Oxidant-induced damage by 200 muM t-BHP in HepG2 cells was inhibited by compounds 1, 4, and 5 (10 and 20 muM), or quercetin (10 muM; positive control).	Quercetin	114-123	latexin	Homo sapiens	30-33
25858254-8	2016	RESULTS: Our results showed that mulberrin, scutellarin, quercetin, and glycyrrhetinic acid were strong inhibitors of OATP2B1-mediate E3S uptake with IC50 values being 1.8, 2.0, 7.5, and 13.0 muM, which were comparable with their plasma concentrations in clinical trials.	Quercetin	57-66	latexin	Homo sapiens	192-195
26366751-6	2016	Slight but significant increases in the mRNA expression of cytochrome P450 3A4, vitamin D3 24-hydroxylase, multidrug resistance protein 1, and transient receptor potential vanilloid type 6 were observed after 3 days of continual quercetin treatment.	Quercetin	229-238	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-78
26366751-6	2016	Slight but significant increases in the mRNA expression of cytochrome P450 3A4, vitamin D3 24-hydroxylase, multidrug resistance protein 1, and transient receptor potential vanilloid type 6 were observed after 3 days of continual quercetin treatment.	Quercetin	229-238	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	80-105
26366751-0	2016	Vitamin D Receptor-Mediated Upregulation of CYP3A4 and MDR1 by Quercetin in Caco-2 cells.	Quercetin	63-72	vitamin D receptor	Homo sapiens	0-18
26366751-0	2016	Vitamin D Receptor-Mediated Upregulation of CYP3A4 and MDR1 by Quercetin in Caco-2 cells.	Quercetin	63-72	ATP binding cassette subfamily B member 1	Homo sapiens	55-59
26366751-6	2016	Slight but significant increases in the mRNA expression of cytochrome P450 3A4, vitamin D3 24-hydroxylase, multidrug resistance protein 1, and transient receptor potential vanilloid type 6 were observed after 3 days of continual quercetin treatment.	Quercetin	229-238	ATP binding cassette subfamily B member 1	Homo sapiens	107-137
26366751-2	2016	The effects of quercetin on the expression of the vitamin D receptor target genes, vitamin D3 24-hydroxylase, cytochrome P450 3A4, multidrug resistance protein 1, and transient receptor potential vanilloid type 6 were measured using quantitative polymerase chain reaction.	Quercetin	15-24	vitamin D receptor	Homo sapiens	50-68
26366751-2	2016	The effects of quercetin on the expression of the vitamin D receptor target genes, vitamin D3 24-hydroxylase, cytochrome P450 3A4, multidrug resistance protein 1, and transient receptor potential vanilloid type 6 were measured using quantitative polymerase chain reaction.	Quercetin	15-24	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	83-108
26366751-8	2016	Moreover, quercetin significantly enhanced cytochrome P450 3A4 reporter activity in Caco-2 cells in a dose-dependent manner, and the expression of exogenous vitamin D receptor further stimulated the vitamin D receptor activity.	Quercetin	10-19	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-62
26366751-8	2016	Moreover, quercetin significantly enhanced cytochrome P450 3A4 reporter activity in Caco-2 cells in a dose-dependent manner, and the expression of exogenous vitamin D receptor further stimulated the vitamin D receptor activity.	Quercetin	10-19	vitamin D receptor	Homo sapiens	199-217
26366751-9	2016	Quercetin-like flavonoids such as kaempferol stimulated the vitamin D receptor activity in a manner similar to that seen with quercetin.	Quercetin	0-9	vitamin D receptor	Homo sapiens	60-78
26366751-10	2016	Taken together, the data indicates that quercetin upregulates cytochrome P450 3A4 and multidrug resistance protein 1 expression in Caco-2 cells likely via a vitamin D receptor-dependent pathway.	Quercetin	40-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-81
26366751-10	2016	Taken together, the data indicates that quercetin upregulates cytochrome P450 3A4 and multidrug resistance protein 1 expression in Caco-2 cells likely via a vitamin D receptor-dependent pathway.	Quercetin	40-49	ATP binding cassette subfamily B member 1	Homo sapiens	86-116
26366751-10	2016	Taken together, the data indicates that quercetin upregulates cytochrome P450 3A4 and multidrug resistance protein 1 expression in Caco-2 cells likely via a vitamin D receptor-dependent pathway.	Quercetin	40-49	vitamin D receptor	Homo sapiens	157-175
26525112-6	2015	Quercetin, telmisartan, diclofenac, and mulberrin displayed a relatively strong inhibition against OAT3 mediated uptake of SVG with IC50 values of 1.8, 2.9, 8.0, and 10.0 muM, respectively.	Quercetin	0-9	solute carrier family 22 member 8	Homo sapiens	99-103
30198658-4	2016	The adding quercetin into induction medium (1 or 10 mmol/l) enhanced themanifestation of signs of hepatic differentiation MSCs such as urea secretion, cytokeratin 19 and a-fetoproteinsynthesis.	Quercetin	11-20	keratin 19	Homo sapiens	151-165
26690102-9	2015	A decrease in the levels of oxidative stress markers, NOx production and iNOS expression associated with elevated activity of antioxidant enzymes in the aortic tissue were observed in quercetin-treated diabetic trained rats.	Quercetin	184-193	nitric oxide synthase 2	Rattus norvegicus	73-77
26041159-1	2015	This work is to study the potential of particles fabricated from soy protein isolate (SPI) as a protective carrier for quercetin.	Quercetin	119-128	chromogranin A	Homo sapiens	86-89
26041159-2	2015	When the concentration of SPI particles increases from 0 to 0.35 g/L, quercetin gives a gradually increased fluorescence intensity and fluorescence anisotropy.	Quercetin	70-79	chromogranin A	Homo sapiens	26-29
26041159-3	2015	The addition of quercetin can highly quench the intrinsic fluorescence of SPI particles.	Quercetin	16-25	chromogranin A	Homo sapiens	74-77
26041159-4	2015	These results are explained in terms of the binding of quercetin to the hydrophobic pockets of SPI particles mainly through the hydrophobic force together with the hydrogen bonding.	Quercetin	55-64	chromogranin A	Homo sapiens	95-98
26041159-6	2015	The relative changes in values of Gibbs energy, enthalpy, and entropy indicate that the binding of quercetin with SPI particles is spontaneous and hydrophobic interaction is the major force.	Quercetin	99-108	chromogranin A	Homo sapiens	114-117
26041159-7	2015	Furthermore, SPI particles are superior to native SPI for improving the stability and radical scavenging activity of quercetin.	Quercetin	117-126	chromogranin A	Homo sapiens	13-16
26041159-7	2015	Furthermore, SPI particles are superior to native SPI for improving the stability and radical scavenging activity of quercetin.	Quercetin	117-126	chromogranin A	Homo sapiens	50-53
26260273-6	2016	The MDC fluorescence was enhanced with increased concentration of quercetin and hit a plateau at 50 mumol/l.	Quercetin	66-75	C-C motif chemokine ligand 22	Homo sapiens	4-7
26712783-4	2015	Mechanism studies identified that quercetin showed interaction with the HA2 subunit.	Quercetin	34-43	keratin 32	Homo sapiens	72-75
26525112-6	2015	Quercetin, telmisartan, diclofenac, and mulberrin displayed a relatively strong inhibition against OAT3 mediated uptake of SVG with IC50 values of 1.8, 2.9, 8.0, and 10.0 muM, respectively.	Quercetin	0-9	latexin	Homo sapiens	171-174
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Quercetin	23-32	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	75-78
25893829-0	2015	Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are Mediated by CB1 Receptor in Human Colon Cancer Cell Lines.	Quercetin	58-67	cannabinoid receptor 1	Homo sapiens	84-87
25893829-4	2015	We observed a significant increase in the expression of the endocannabinoids receptor (CB1-R) after quercetin treatment.	Quercetin	100-109	cannabinoid receptor 1	Homo sapiens	87-92
25893829-5	2015	CB1-R can be considered an estrogen responsive receptor and quercetin, having a structure similar to that of the estrogens, can interact with CB1-R leading to the regulation of cell growth.	Quercetin	60-69	cannabinoid receptor 1	Homo sapiens	0-5
25893829-5	2015	CB1-R can be considered an estrogen responsive receptor and quercetin, having a structure similar to that of the estrogens, can interact with CB1-R leading to the regulation of cell growth.	Quercetin	60-69	cannabinoid receptor 1	Homo sapiens	142-147
25893829-6	2015	In order to clarify the contribution of the CB1-R to the quercetin action, we investigated some of the principal molecular pathways that are inhibited or activated by this natural compound.	Quercetin	57-66	cannabinoid receptor 1	Homo sapiens	44-49
25893829-9	2015	In all the experiments done, the quercetin action has proven to be reinforced by anandamide (Met-F-AEA), a CB1-R agonist, and partially counteracted by SR141716, a CB1-R antagonist.	Quercetin	33-42	cannabinoid receptor 1	Homo sapiens	107-112
25893829-9	2015	In all the experiments done, the quercetin action has proven to be reinforced by anandamide (Met-F-AEA), a CB1-R agonist, and partially counteracted by SR141716, a CB1-R antagonist.	Quercetin	33-42	cannabinoid receptor 1	Homo sapiens	164-169
26135605-7	2015	Our findings indicated that administration of 10 mg/kg/day of quercetin either alone or with estrogen resulted in decreased uterine expression of PCNA protein and mRNA with the percentage of PCNA-positive cells in uterine luminal and glandular epithelia markedly reduced compared with estrogen-only treatment.	Quercetin	62-71	proliferating cell nuclear antigen	Rattus norvegicus	146-150
26135605-7	2015	Our findings indicated that administration of 10 mg/kg/day of quercetin either alone or with estrogen resulted in decreased uterine expression of PCNA protein and mRNA with the percentage of PCNA-positive cells in uterine luminal and glandular epithelia markedly reduced compared with estrogen-only treatment.	Quercetin	62-71	proliferating cell nuclear antigen	Rattus norvegicus	191-195
26135605-9	2015	Treatment with 100 mg/kg/day of quercetin either alone or with estrogen resulted in elevated PCNA protein and mRNA expression.	Quercetin	32-41	proliferating cell nuclear antigen	Rattus norvegicus	93-97
26432773-0	2015	Quercetin induces hepatic gamma-glutamyl hydrolase expression in rats by suppressing hepatic microRNA rno-miR-125b-3p.	Quercetin	0-9	gamma-glutamyl hydrolase	Rattus norvegicus	26-50
26432773-11	2015	A ninefold reduction in hepatic miRNA rno-miR-125b-3p was paralleled by significant induction of GGH mRNA in liver of quercetin fed rats.	Quercetin	118-127	gamma-glutamyl hydrolase	Rattus norvegicus	97-100
26432773-12	2015	Because increased GGH expressions were repeatedly associated with resistance to methotrexate, concomitant intake with quercetin should be monitored carefully.	Quercetin	118-127	gamma-glutamyl hydrolase	Rattus norvegicus	18-21
26476374-0	2015	Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway.	Quercetin	0-9	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	82-86
26476374-6	2015	Moreover, our results showed that quercetin increased cyclin D1 protein levels and decreased the protein expression of cyclin B1 and Cdc2.	Quercetin	34-43	cyclin D1	Rattus norvegicus	54-63
26476374-6	2015	Moreover, our results showed that quercetin increased cyclin D1 protein levels and decreased the protein expression of cyclin B1 and Cdc2.	Quercetin	34-43	cyclin B1	Rattus norvegicus	119-128
26476374-6	2015	Moreover, our results showed that quercetin increased cyclin D1 protein levels and decreased the protein expression of cyclin B1 and Cdc2.	Quercetin	34-43	cyclin-dependent kinase 1	Rattus norvegicus	133-137
26476374-7	2015	Additionally, quercetin altered the Bax/Bcl-2 ratio and reduced MMP2, MMP9, CXCR4, integrin beta1, and integrin alpha5 expression.	Quercetin	14-23	BCL2 associated X, apoptosis regulator	Rattus norvegicus	36-39
26476374-7	2015	Additionally, quercetin altered the Bax/Bcl-2 ratio and reduced MMP2, MMP9, CXCR4, integrin beta1, and integrin alpha5 expression.	Quercetin	14-23	BCL2, apoptosis regulator	Rattus norvegicus	40-45
26476374-7	2015	Additionally, quercetin altered the Bax/Bcl-2 ratio and reduced MMP2, MMP9, CXCR4, integrin beta1, and integrin alpha5 expression.	Quercetin	14-23	matrix metallopeptidase 2	Rattus norvegicus	64-68
26476374-7	2015	Additionally, quercetin altered the Bax/Bcl-2 ratio and reduced MMP2, MMP9, CXCR4, integrin beta1, and integrin alpha5 expression.	Quercetin	14-23	matrix metallopeptidase 9	Rattus norvegicus	70-74
26476374-7	2015	Additionally, quercetin altered the Bax/Bcl-2 ratio and reduced MMP2, MMP9, CXCR4, integrin beta1, and integrin alpha5 expression.	Quercetin	14-23	C-X-C motif chemokine receptor 4	Rattus norvegicus	76-81
26476374-7	2015	Additionally, quercetin altered the Bax/Bcl-2 ratio and reduced MMP2, MMP9, CXCR4, integrin beta1, and integrin alpha5 expression.	Quercetin	14-23	integrin subunit beta 1	Rattus norvegicus	83-97
26476374-7	2015	Additionally, quercetin altered the Bax/Bcl-2 ratio and reduced MMP2, MMP9, CXCR4, integrin beta1, and integrin alpha5 expression.	Quercetin	14-23	integrin subunit alpha 5	Rattus norvegicus	103-118
26476374-9	2015	In addition, activation of the TrkA/AKT signaling cascade during hypoxia was inhibited by quercetin in a dose-dependent manner.	Quercetin	90-99	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	31-35
26476374-9	2015	In addition, activation of the TrkA/AKT signaling cascade during hypoxia was inhibited by quercetin in a dose-dependent manner.	Quercetin	90-99	AKT serine/threonine kinase 1	Rattus norvegicus	36-39
26476374-10	2015	Moreover, quercetin alone inhibited the TrkA/AKT signaling pathway, resulting in decreased PASMC migration, cell cycle arrest and the induction of apoptosis.	Quercetin	10-19	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	40-44
26476374-10	2015	Moreover, quercetin alone inhibited the TrkA/AKT signaling pathway, resulting in decreased PASMC migration, cell cycle arrest and the induction of apoptosis.	Quercetin	10-19	AKT serine/threonine kinase 1	Rattus norvegicus	45-48
26050647-10	2015	Adding a fixed quercetin dose enhanced gemcitabine-induced cell death, which was related to increased caspase-3 and caspase-9 activities.	Quercetin	15-24	caspase 9	Homo sapiens	116-125
26050647-11	2015	Combination treatment with quercetin and gemcitabine downregulated HSP70 expression more prominently than treatment with quercetin or gemcitabine alone.	Quercetin	27-36	heat shock protein family A (Hsp70) member 4	Homo sapiens	67-72
26050647-11	2015	Combination treatment with quercetin and gemcitabine downregulated HSP70 expression more prominently than treatment with quercetin or gemcitabine alone.	Quercetin	121-130	heat shock protein family A (Hsp70) member 4	Homo sapiens	67-72
26050647-12	2015	CONCLUSION: Quercetin-induced HSP70 inhibition was involved in growth inhibition and sensitization to chemotreatment in lung cancer cells.	Quercetin	12-21	heat shock protein family A (Hsp70) member 4	Homo sapiens	30-35
26352537-8	2015	These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway.	Quercetin	220-229	catenin beta 1	Rattus norvegicus	89-101
26352537-8	2015	These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway.	Quercetin	220-229	glycogen synthase kinase 3 beta	Rattus norvegicus	147-156
26352537-8	2015	These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway.	Quercetin	220-229	catenin beta 1	Rattus norvegicus	252-264
26277481-0	2015	The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling.	Quercetin	26-35	mitogen-activated protein kinase 1	Mus musculus	97-101
26277481-5	2015	Quercetin suppressed protein levels of the key adipogenic factors C/EBPbeta, C/EBPalpha, PPARgamma and FABP4 and the TG-synthesis enzymes lipin1, DGAT1 and LPAATtheta.	Quercetin	0-9	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	66-75
26277481-5	2015	Quercetin suppressed protein levels of the key adipogenic factors C/EBPbeta, C/EBPalpha, PPARgamma and FABP4 and the TG-synthesis enzymes lipin1, DGAT1 and LPAATtheta.	Quercetin	0-9	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	77-87
26277481-5	2015	Quercetin suppressed protein levels of the key adipogenic factors C/EBPbeta, C/EBPalpha, PPARgamma and FABP4 and the TG-synthesis enzymes lipin1, DGAT1 and LPAATtheta.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Mus musculus	89-98
26277481-5	2015	Quercetin suppressed protein levels of the key adipogenic factors C/EBPbeta, C/EBPalpha, PPARgamma and FABP4 and the TG-synthesis enzymes lipin1, DGAT1 and LPAATtheta.	Quercetin	0-9	fatty acid binding protein 4, adipocyte	Mus musculus	103-108
26277481-5	2015	Quercetin suppressed protein levels of the key adipogenic factors C/EBPbeta, C/EBPalpha, PPARgamma and FABP4 and the TG-synthesis enzymes lipin1, DGAT1 and LPAATtheta.	Quercetin	0-9	lipin 1	Mus musculus	138-144
26277481-5	2015	Quercetin suppressed protein levels of the key adipogenic factors C/EBPbeta, C/EBPalpha, PPARgamma and FABP4 and the TG-synthesis enzymes lipin1, DGAT1 and LPAATtheta.	Quercetin	0-9	diacylglycerol O-acyltransferase 1	Mus musculus	146-151
26277481-5	2015	Quercetin suppressed protein levels of the key adipogenic factors C/EBPbeta, C/EBPalpha, PPARgamma and FABP4 and the TG-synthesis enzymes lipin1, DGAT1 and LPAATtheta.	Quercetin	0-9	glycerol-3-phosphate acyltransferase 3	Mus musculus	156-166
26277481-8	2015	Our data showed that quercetin inhibited the MAPK signaling factors ERK1/2, JNK and p38MAPK and MCP-1 and TNF-alpha in adipocytes and macrophages.	Quercetin	21-30	mitogen-activated protein kinase 1	Mus musculus	45-49
26277481-8	2015	Our data showed that quercetin inhibited the MAPK signaling factors ERK1/2, JNK and p38MAPK and MCP-1 and TNF-alpha in adipocytes and macrophages.	Quercetin	21-30	mitogen-activated protein kinase 3	Mus musculus	68-74
26277481-8	2015	Our data showed that quercetin inhibited the MAPK signaling factors ERK1/2, JNK and p38MAPK and MCP-1 and TNF-alpha in adipocytes and macrophages.	Quercetin	21-30	mitogen-activated protein kinase 8	Mus musculus	76-79
26277481-8	2015	Our data showed that quercetin inhibited the MAPK signaling factors ERK1/2, JNK and p38MAPK and MCP-1 and TNF-alpha in adipocytes and macrophages.	Quercetin	21-30	mitogen-activated protein kinase 14	Mus musculus	84-91
26277481-8	2015	Our data showed that quercetin inhibited the MAPK signaling factors ERK1/2, JNK and p38MAPK and MCP-1 and TNF-alpha in adipocytes and macrophages.	Quercetin	21-30	mast cell protease 1	Mus musculus	96-101
26277481-8	2015	Our data showed that quercetin inhibited the MAPK signaling factors ERK1/2, JNK and p38MAPK and MCP-1 and TNF-alpha in adipocytes and macrophages.	Quercetin	21-30	tumor necrosis factor	Mus musculus	106-115
26277481-9	2015	Quercetin also inhibited secretion of the inflammatory cytokines IL-1beta and IL-6 and stimulated that of IL-10, an antiinflammatory cytokine.	Quercetin	0-9	interleukin 1 beta	Mus musculus	65-73
26277481-9	2015	Quercetin also inhibited secretion of the inflammatory cytokines IL-1beta and IL-6 and stimulated that of IL-10, an antiinflammatory cytokine.	Quercetin	0-9	interleukin 6	Mus musculus	78-82
26277481-9	2015	Quercetin also inhibited secretion of the inflammatory cytokines IL-1beta and IL-6 and stimulated that of IL-10, an antiinflammatory cytokine.	Quercetin	0-9	interleukin 10	Mus musculus	106-111
26434546-9	2015	The number of TUNEL positive cells in the inner and outer hair cells in the Corti organ was found to be fewer, and Caspase 3 and 9 expressions were found to be weaker in the group receiving gentamicin plus quercetin than in the group receiving gentamicin plus ethanol.	Quercetin	206-215	caspase 3	Rattus norvegicus	115-124
26560479-5	2015	Quercetin appeared to be a strong antioxidant when the FRAP test was performed and the strongest for ABTS and DPPH tests whereas genkwanin was the weakest antioxidant for three tests (FRAP, ABTS, and DPPH).	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	55-59
26493151-0	2015	Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1alpha signaling pathway.	Quercetin	0-9	PPARG coactivator 1 alpha	Rattus norvegicus	122-132
26493151-1	2015	The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against aluminium-induced oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of PGC-1alpha and its downstream targets, i.e. NRF-1, NRF-2 and Tfam in mitochondrial biogenesis.	Quercetin	122-131	PPARG coactivator 1 alpha	Rattus norvegicus	281-291
26493151-1	2015	The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against aluminium-induced oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of PGC-1alpha and its downstream targets, i.e. NRF-1, NRF-2 and Tfam in mitochondrial biogenesis.	Quercetin	122-131	nuclear respiratory factor 1	Rattus norvegicus	325-330
26493151-1	2015	The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against aluminium-induced oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of PGC-1alpha and its downstream targets, i.e. NRF-1, NRF-2 and Tfam in mitochondrial biogenesis.	Quercetin	122-131	NFE2 like bZIP transcription factor 2	Rattus norvegicus	332-337
26493151-1	2015	The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against aluminium-induced oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of PGC-1alpha and its downstream targets, i.e. NRF-1, NRF-2 and Tfam in mitochondrial biogenesis.	Quercetin	122-131	transcription factor A, mitochondrial	Rattus norvegicus	342-346
26493151-6	2015	The PGC-1alpha was up regulated in quercetin treated rats along with NRF-1, NRF-2 and Tfam, which act downstream from PGC-1alpha.	Quercetin	35-44	PPARG coactivator 1 alpha	Rattus norvegicus	4-14
26493151-6	2015	The PGC-1alpha was up regulated in quercetin treated rats along with NRF-1, NRF-2 and Tfam, which act downstream from PGC-1alpha.	Quercetin	35-44	nuclear respiratory factor 1	Rattus norvegicus	69-74
26493151-6	2015	The PGC-1alpha was up regulated in quercetin treated rats along with NRF-1, NRF-2 and Tfam, which act downstream from PGC-1alpha.	Quercetin	35-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	76-81
26493151-6	2015	The PGC-1alpha was up regulated in quercetin treated rats along with NRF-1, NRF-2 and Tfam, which act downstream from PGC-1alpha.	Quercetin	35-44	transcription factor A, mitochondrial	Rattus norvegicus	86-90
26493151-6	2015	The PGC-1alpha was up regulated in quercetin treated rats along with NRF-1, NRF-2 and Tfam, which act downstream from PGC-1alpha.	Quercetin	35-44	PPARG coactivator 1 alpha	Rattus norvegicus	118-128
26050647-0	2015	Quercetin Enhances Chemosensitivity to Gemcitabine in Lung Cancer Cells by Inhibiting Heat Shock Protein 70 Expression.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	86-107
26050647-2	2015	We demonstrated that quercetin inhibited cancer cell growth and sensitized cancer cells to gemcitabine treatment by promoting apoptosis via inhibiting heat shock protein 70 expression.	Quercetin	21-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	151-172
26050647-6	2015	We investigated whether quercetin-induced inhibition of heat shock protein 70 (HSP70) is involved in its anticancer activity and whether it could modulate the responsiveness of lung cancer cells to chemotherapy.	Quercetin	24-33	heat shock protein family A (Hsp70) member 4	Homo sapiens	56-77
26050647-6	2015	We investigated whether quercetin-induced inhibition of heat shock protein 70 (HSP70) is involved in its anticancer activity and whether it could modulate the responsiveness of lung cancer cells to chemotherapy.	Quercetin	24-33	heat shock protein family A (Hsp70) member 4	Homo sapiens	79-84
26050647-9	2015	RESULTS: Quercetin reduced cell viability and suppressed HSP70 expression in both cell lines dose-dependently.	Quercetin	9-18	heat shock protein family A (Hsp70) member 4	Homo sapiens	57-62
26050647-10	2015	Adding a fixed quercetin dose enhanced gemcitabine-induced cell death, which was related to increased caspase-3 and caspase-9 activities.	Quercetin	15-24	caspase 3	Homo sapiens	102-111
26546527-12	2015	Gene expression of Cox2, Tnfalpha and Nos2 stimulated by exposure to Pg-fimbriae was markedly suppressed by quercetin, but was not modulated by its combination with epicatechin.	Quercetin	108-117	prostaglandin-endoperoxide synthase 2	Mus musculus	19-23
26546527-12	2015	Gene expression of Cox2, Tnfalpha and Nos2 stimulated by exposure to Pg-fimbriae was markedly suppressed by quercetin, but was not modulated by its combination with epicatechin.	Quercetin	108-117	tumor necrosis factor	Mus musculus	25-33
26546527-12	2015	Gene expression of Cox2, Tnfalpha and Nos2 stimulated by exposure to Pg-fimbriae was markedly suppressed by quercetin, but was not modulated by its combination with epicatechin.	Quercetin	108-117	nitric oxide synthase 2, inducible	Mus musculus	38-42
26546527-13	2015	The 50% inhibitory concentration of quercetin for Cox2 expression was approximately 10 muM, while that of catechin and epicatechin was approximately 500 muM.	Quercetin	36-45	prostaglandin-endoperoxide synthase 2	Mus musculus	50-54
26140983-11	2015	Based on these findings, we predicted that quercetin would inhibit activities of Src family kinases with greater potency than apigenin and catechin.	Quercetin	43-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	81-84
26445592-0	2015	Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1.	Quercetin	0-9	heme oxygenase 1	Mus musculus	102-118
26398703-9	2015	In addition, quercetin treatment suppressed the increase of C/EBP homologous protein, and inhibited the activation of JNK and caspase-12, which was induced by glucosamine.	Quercetin	13-22	mitogen-activated protein kinase 8	Mus musculus	118-121
26398703-9	2015	In addition, quercetin treatment suppressed the increase of C/EBP homologous protein, and inhibited the activation of JNK and caspase-12, which was induced by glucosamine.	Quercetin	13-22	caspase 12	Mus musculus	126-136
26639503-4	2015	This study was designed to investigate the changes in serum level of adiponectin in diabetic rats treated with hydroalcoholic extracts of three medicinal plants; jujube (Ziziphus jujuba), barberry (Berberis vulgaris) and saffron (Crocus sativus) in comparison with quercetin.	Quercetin	265-274	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	69-80
26639503-12	2015	These beneficial effects of C. sativus, B. vulgaris and Z. jujube extracts and quercetin in diabetic rats may be associated with increase in adiponectin level.	Quercetin	79-88	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	141-152
26076811-0	2015	Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention.	Quercetin	160-169	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	140-145
26076811-8	2015	Quercetin modulates the expression of almost all isozymes of classical, novel, and atypical PKC as well as downregulates the level and expression of PKCalpha.	Quercetin	0-9	protein kinase C, alpha	Mus musculus	149-157
26076811-9	2015	Further, quercetin improves apoptotic potential, as observed by the levels of caspase 3, caspase 9, PARP, PKCdelta, and nuclear condensation.	Quercetin	9-18	caspase 3	Mus musculus	78-87
26076811-9	2015	Further, quercetin improves apoptotic potential, as observed by the levels of caspase 3, caspase 9, PARP, PKCdelta, and nuclear condensation.	Quercetin	9-18	caspase 9	Mus musculus	89-98
26076811-9	2015	Further, quercetin improves apoptotic potential, as observed by the levels of caspase 3, caspase 9, PARP, PKCdelta, and nuclear condensation.	Quercetin	9-18	poly (ADP-ribose) polymerase family, member 1	Mus musculus	100-104
26076811-9	2015	Further, quercetin improves apoptotic potential, as observed by the levels of caspase 3, caspase 9, PARP, PKCdelta, and nuclear condensation.	Quercetin	9-18	protein kinase C, delta	Mus musculus	106-114
26076811-10	2015	Additionally, quercetin reduces cell survival and promotes death receptor-mediated apoptosis via differential localization of the TNFR1 level in ascite cells.	Quercetin	14-23	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	130-135
26505893-0	2015	Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	91-95
26505893-0	2015	Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1.	Quercetin	0-9	heme oxygenase 1	Mus musculus	121-137
26505893-4	2015	Quercetin was 10 folds more potent than cyanidin in inhibition of lipopolysaccharide (LPS)-induced NO production as well as stimulation of Nrf2-induced heme-oxygenase-1 (HO-1) protein expression.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-143
26505893-4	2015	Quercetin was 10 folds more potent than cyanidin in inhibition of lipopolysaccharide (LPS)-induced NO production as well as stimulation of Nrf2-induced heme-oxygenase-1 (HO-1) protein expression.	Quercetin	0-9	heme oxygenase 1	Mus musculus	152-168
26505893-4	2015	Quercetin was 10 folds more potent than cyanidin in inhibition of lipopolysaccharide (LPS)-induced NO production as well as stimulation of Nrf2-induced heme-oxygenase-1 (HO-1) protein expression.	Quercetin	0-9	heme oxygenase 1	Mus musculus	170-174
26505893-5	2015	In addition, quercetin demonstrated enhanced ability to stimulate HO-1 protein expression when cells were treated with LPS.	Quercetin	13-22	heme oxygenase 1	Mus musculus	66-70
26505893-6	2015	In an attempt to unveil mechanism(s) for quercetin to enhance Nrf2/HO-1 activity under endotoxic stress, results pointed to an increase in phospho-p38MAPK expression upon addition of quercetin to LPS.	Quercetin	41-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	62-66
26505893-6	2015	In an attempt to unveil mechanism(s) for quercetin to enhance Nrf2/HO-1 activity under endotoxic stress, results pointed to an increase in phospho-p38MAPK expression upon addition of quercetin to LPS.	Quercetin	41-50	heme oxygenase 1	Mus musculus	67-71
26505893-6	2015	In an attempt to unveil mechanism(s) for quercetin to enhance Nrf2/HO-1 activity under endotoxic stress, results pointed to an increase in phospho-p38MAPK expression upon addition of quercetin to LPS.	Quercetin	41-50	mitogen-activated protein kinase 14	Mus musculus	147-154
26505893-6	2015	In an attempt to unveil mechanism(s) for quercetin to enhance Nrf2/HO-1 activity under endotoxic stress, results pointed to an increase in phospho-p38MAPK expression upon addition of quercetin to LPS.	Quercetin	183-192	nuclear factor, erythroid derived 2, like 2	Mus musculus	62-66
26505893-6	2015	In an attempt to unveil mechanism(s) for quercetin to enhance Nrf2/HO-1 activity under endotoxic stress, results pointed to an increase in phospho-p38MAPK expression upon addition of quercetin to LPS.	Quercetin	183-192	heme oxygenase 1	Mus musculus	67-71
26505893-6	2015	In an attempt to unveil mechanism(s) for quercetin to enhance Nrf2/HO-1 activity under endotoxic stress, results pointed to an increase in phospho-p38MAPK expression upon addition of quercetin to LPS.	Quercetin	183-192	mitogen-activated protein kinase 14	Mus musculus	147-154
26505893-9	2015	Taken together, results suggest an important role of quercetin to regulate inflammatory responses in microglial cells and its ability to upregulate HO-1 against endotoxic stress through involvement of MAPKs.	Quercetin	53-62	heme oxygenase 1	Mus musculus	148-152
26445592-9	2015	Moreover, the metabolic changes and the lipid-lowering effects of quercetin were completely blocked by the HO-1 inhibitor ZnPP and by deficiency of Nrf-2.	Quercetin	66-75	heme oxygenase 1	Mus musculus	107-111
26445592-9	2015	Moreover, the metabolic changes and the lipid-lowering effects of quercetin were completely blocked by the HO-1 inhibitor ZnPP and by deficiency of Nrf-2.	Quercetin	66-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	148-153
26445592-10	2015	CONCLUSION: These findings suggest that quercetin stimulates hepatic mitochondrial oxidative metabolism by inducing HO-1 via the Nrf-2 pathway.	Quercetin	40-49	heme oxygenase 1	Mus musculus	116-120
26445592-10	2015	CONCLUSION: These findings suggest that quercetin stimulates hepatic mitochondrial oxidative metabolism by inducing HO-1 via the Nrf-2 pathway.	Quercetin	40-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	129-134
26284537-0	2015	Quercetin Mediates beta-Catenin in Pancreatic Cancer Stem-Like Cells.	Quercetin	0-9	catenin beta 1	Homo sapiens	19-31
26284537-9	2015	Targeting beta-catenin using quercetin combined with gemcitabine may be a treatment strategy to improve prognosis in patients with pancreatic cancer.	Quercetin	29-38	catenin beta 1	Homo sapiens	10-22
26491966-2	2015	In this study, we investigated the anti-proliferative effect of quercetin in two breast cancer cell lines (MCF-7 and MDA-MB-231), which differed in hormone receptor.	Quercetin	64-73	nuclear receptor subfamily 4 group A member 1	Homo sapiens	148-164
26491966-6	2015	In addition, quercetin effectively suppressed the expression of CyclinD1, p21, Twist and phospho p38MAPK, which was not observed in MDA-MB-231 cells.	Quercetin	13-22	cyclin D1	Homo sapiens	64-72
26491966-6	2015	In addition, quercetin effectively suppressed the expression of CyclinD1, p21, Twist and phospho p38MAPK, which was not observed in MDA-MB-231 cells.	Quercetin	13-22	H3 histone pseudogene 16	Homo sapiens	74-77
26491966-8	2015	Quercetin effectively regulated the expression of Twist, in turn p16 and p21 which induced apoptosis in MCF-7 cells.	Quercetin	0-9	cyclin dependent kinase inhibitor 2A	Homo sapiens	65-68
26491966-8	2015	Quercetin effectively regulated the expression of Twist, in turn p16 and p21 which induced apoptosis in MCF-7 cells.	Quercetin	0-9	H3 histone pseudogene 16	Homo sapiens	73-76
26445592-3	2015	Here, we demonstrate that the phytochemical, quercetin, a natural polyphenol flavonoid, protects against hepatic steatosis in obese mice fed a high-fat diet, and that it does so by inducing HO-1 and stimulating increased hepatic mitochondrial oxidative metabolism.	Quercetin	45-54	heme oxygenase 1	Mus musculus	190-194
26445592-7	2015	RESULTS: Quercetin upregulated genes involved in mitochondrial biogenesis and oxidative metabolism in lipid-laden hepatocytes and the livers of HFD-fed obese mice, and this was accompanied by increased levels of the transcription factor, nuclear erythroid 2-related factor 2 (Nrf-2), and HO-1 protein.	Quercetin	9-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	238-274
26445592-7	2015	RESULTS: Quercetin upregulated genes involved in mitochondrial biogenesis and oxidative metabolism in lipid-laden hepatocytes and the livers of HFD-fed obese mice, and this was accompanied by increased levels of the transcription factor, nuclear erythroid 2-related factor 2 (Nrf-2), and HO-1 protein.	Quercetin	9-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	276-281
26445592-7	2015	RESULTS: Quercetin upregulated genes involved in mitochondrial biogenesis and oxidative metabolism in lipid-laden hepatocytes and the livers of HFD-fed obese mice, and this was accompanied by increased levels of the transcription factor, nuclear erythroid 2-related factor 2 (Nrf-2), and HO-1 protein.	Quercetin	9-18	heme oxygenase 1	Mus musculus	288-292
25537132-6	2015	However, treatment of both vincristine and quercetin for a similar period reduced the serum CK-MB, LDH, SGPT and cTnT levels near to normal levels in ISO-treated rats.	Quercetin	43-52	troponin T2, cardiac type	Rattus norvegicus	113-117
26297952-7	2015	Quercetin lowered levels of interleukin-1beta, C-reactive protein, and monocyte chemotactic protein-1 and restored plasma antioxidant capacity.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	28-45
26297952-7	2015	Quercetin lowered levels of interleukin-1beta, C-reactive protein, and monocyte chemotactic protein-1 and restored plasma antioxidant capacity.	Quercetin	0-9	C-reactive protein	Rattus norvegicus	47-65
26297952-7	2015	Quercetin lowered levels of interleukin-1beta, C-reactive protein, and monocyte chemotactic protein-1 and restored plasma antioxidant capacity.	Quercetin	0-9	C-C motif chemokine ligand 2	Rattus norvegicus	71-101
26297952-8	2015	In addition, quercetin inhibited the enzymatic activity of pro-inflammatory 12/15-lipoxygenase in lung and liver and increased the expression of heme oxygenase-1 in joint and lung of arthritic rats.	Quercetin	13-22	heme oxygenase 1	Rattus norvegicus	145-161
26297952-9	2015	Finally, quercetin inhibited the 2-fold increase of NF-kB activity observed in lung, liver and joint after induction of arthritis.	Quercetin	9-18	nuclear factor kappa B subunit 1	Rattus norvegicus	52-57
26622474-5	2015	This effect was accompanied by significantly decreased expression of vascular cell adhesion molecule 1 (VCAM-1) and cluster of differentiation (CD)80 for taraxasterol and that of CD80 for quercetin.	Quercetin	188-197	CD80 molecule	Homo sapiens	179-183
26622474-6	2015	In conclusion, the present study showed the protective effects of quercetin and taraxasterol against cell injury and inflammation in HUVECs and indicated that the effects were mediated via the downregulation of VCAM-1 and CD80 expression.	Quercetin	66-75	vascular cell adhesion molecule 1	Homo sapiens	211-217
26622474-6	2015	In conclusion, the present study showed the protective effects of quercetin and taraxasterol against cell injury and inflammation in HUVECs and indicated that the effects were mediated via the downregulation of VCAM-1 and CD80 expression.	Quercetin	66-75	CD80 molecule	Homo sapiens	222-226
26153070-0	2015	Quercetin improves the activity of the ubiquitin-proteasomal system in 150Q mutated huntingtin-expressing cells but exerts detrimental effects on neuronal survivability.	Quercetin	0-9	huntingtin	Mus musculus	84-94
26374991-5	2015	Pretreatment with quercetin or hydroxytyrosol attenuated the phosphorylation of MAPKAPK-2 and cleaved caspase-3 in X/XO-exposed cells (p &lt; 0.01, vs. X/XO).	Quercetin	18-27	MAPK activated protein kinase 2	Homo sapiens	80-89
26374991-5	2015	Pretreatment with quercetin or hydroxytyrosol attenuated the phosphorylation of MAPKAPK-2 and cleaved caspase-3 in X/XO-exposed cells (p &lt; 0.01, vs. X/XO).	Quercetin	18-27	caspase 3	Homo sapiens	102-111
26153070-8	2015	These results suggest that, although quercetin at a low dose protects against mHtt-mediated cell death, higher doses are toxic to the cells, clearly demarcating a narrow therapeutic window for this dietary flavonoid.	Quercetin	37-46	huntingtin	Mus musculus	78-82
26153070-2	2015	Cells were protected from death by a 20-microM dose of quercetin on the second day of Htt induction, but 30-100-microM doses of the drug caused further toxicity in both 16Q and 150Q cells, as indicated by MTT assay and by significant reductions in the number of cells bearing neurites on the second day.	Quercetin	55-64	huntingtin	Coturnix japonica	86-89
26153070-4	2015	Mutated Htt (mHtt)-induced reduction in proteasomal activity of the ubiquitin-proteasomal system (UPS) was significantly attenuated by 20 microM quercetin.	Quercetin	145-154	huntingtin	Mus musculus	8-11
26153070-4	2015	Mutated Htt (mHtt)-induced reduction in proteasomal activity of the ubiquitin-proteasomal system (UPS) was significantly attenuated by 20 microM quercetin.	Quercetin	145-154	huntingtin	Mus musculus	13-17
26153070-6	2015	Our results imply that the neuroprotective effect of quercetin arises out of the upregulation of UPS activity, which causes a decrease in the number of mHtt aggregate-harboring cells.	Quercetin	53-62	huntingtin	Mus musculus	152-156
26202455-0	2015	Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation.	Quercetin	0-9	sirtuin 1	Homo sapiens	69-74
26202455-4	2015	This study was designed to confirm the hypothesis that quercetin inhibits oxidized LDL (oxLDL) induced endothelial oxidative damage by activating sirtuin 1 (SIRT1) and to explore the role of adenosine monophosphate activated protein kinase (AMPK), which is a negative regulator of Nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) and free radicals.	Quercetin	55-64	sirtuin 1	Homo sapiens	146-155
26202455-4	2015	This study was designed to confirm the hypothesis that quercetin inhibits oxidized LDL (oxLDL) induced endothelial oxidative damage by activating sirtuin 1 (SIRT1) and to explore the role of adenosine monophosphate activated protein kinase (AMPK), which is a negative regulator of Nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) and free radicals.	Quercetin	55-64	sirtuin 1	Homo sapiens	157-162
26202455-4	2015	This study was designed to confirm the hypothesis that quercetin inhibits oxidized LDL (oxLDL) induced endothelial oxidative damage by activating sirtuin 1 (SIRT1) and to explore the role of adenosine monophosphate activated protein kinase (AMPK), which is a negative regulator of Nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) and free radicals.	Quercetin	55-64	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	241-245
26202455-6	2015	We found that quercetin pretreatment increased SIRT1 mRNA expression.	Quercetin	14-23	sirtuin 1	Homo sapiens	47-52
26202455-7	2015	In fact, quercetin protected against oxLDL-impaired SIRT1 and AMPK activities and reduced oxLDL-activated NOX2 and NOX4.	Quercetin	9-18	sirtuin 1	Homo sapiens	52-57
26202455-7	2015	In fact, quercetin protected against oxLDL-impaired SIRT1 and AMPK activities and reduced oxLDL-activated NOX2 and NOX4.	Quercetin	9-18	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	62-66
26202455-7	2015	In fact, quercetin protected against oxLDL-impaired SIRT1 and AMPK activities and reduced oxLDL-activated NOX2 and NOX4.	Quercetin	9-18	cytochrome b-245 beta chain	Homo sapiens	106-110
26202455-7	2015	In fact, quercetin protected against oxLDL-impaired SIRT1 and AMPK activities and reduced oxLDL-activated NOX2 and NOX4.	Quercetin	9-18	NADPH oxidase 4	Homo sapiens	115-119
26202455-8	2015	However, silencing SIRT1 and AMPK diminished the protective function of quercetin against oxidative injuries.	Quercetin	72-81	sirtuin 1	Homo sapiens	19-24
26202455-8	2015	However, silencing SIRT1 and AMPK diminished the protective function of quercetin against oxidative injuries.	Quercetin	72-81	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	29-33
26202455-11	2015	Quercetin suppresses oxLDL-induced endothelial oxidative injuries by activating SIRT1 and modulating the AMPK/NADPH oxidase/AKT/endothelial NO synthase signaling pathway.	Quercetin	0-9	sirtuin 1	Homo sapiens	80-85
26202455-11	2015	Quercetin suppresses oxLDL-induced endothelial oxidative injuries by activating SIRT1 and modulating the AMPK/NADPH oxidase/AKT/endothelial NO synthase signaling pathway.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	105-109
26202455-11	2015	Quercetin suppresses oxLDL-induced endothelial oxidative injuries by activating SIRT1 and modulating the AMPK/NADPH oxidase/AKT/endothelial NO synthase signaling pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	124-127
26238175-4	2015	By comparison, 3-hydroxyflavone activated rat PXR, whereas 3-hydroxyflavone, galangin, quercetin, isorhamnetin, and tamarixetin activated human PXR (hPXR).	Quercetin	87-96	nuclear receptor subfamily 1 group I member 2	Homo sapiens	144-147
26238175-4	2015	By comparison, 3-hydroxyflavone activated rat PXR, whereas 3-hydroxyflavone, galangin, quercetin, isorhamnetin, and tamarixetin activated human PXR (hPXR).	Quercetin	87-96	nuclear receptor subfamily 1 group I member 2	Homo sapiens	149-153
26238175-7	2015	In LS180 human colon adenocarcinoma cells, 3-hydroxyflavone, quercetin, and tamarixetin increased CYP3A4, CYP3A5, and ABCB1 mRNA expression, whereas galangin and isorhamnetin increased CYP3A4 and ABCB1 but not CYP3A5 mRNA expression.	Quercetin	61-70	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-104
26238175-5	2015	A time-resolved fluorescence resonance energy transfer competitive ligand-binding assay showed binding to the ligand-binding domain of hPXR by 3-hydroxyflavone, galangin, quercetin, isorhamnetin, and tamarixetin.	Quercetin	171-180	nuclear receptor subfamily 1 group I member 2	Homo sapiens	135-139
26238175-7	2015	In LS180 human colon adenocarcinoma cells, 3-hydroxyflavone, quercetin, and tamarixetin increased CYP3A4, CYP3A5, and ABCB1 mRNA expression, whereas galangin and isorhamnetin increased CYP3A4 and ABCB1 but not CYP3A5 mRNA expression.	Quercetin	61-70	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	106-112
26412426-0	2015	Quercetin promotes neurite growth through enhancing intracellular cAMP level and GAP-43 expression.	Quercetin	0-9	growth associated protein 43	Mus musculus	81-87
26238175-7	2015	In LS180 human colon adenocarcinoma cells, 3-hydroxyflavone, quercetin, and tamarixetin increased CYP3A4, CYP3A5, and ABCB1 mRNA expression, whereas galangin and isorhamnetin increased CYP3A4 and ABCB1 but not CYP3A5 mRNA expression.	Quercetin	61-70	ATP binding cassette subfamily B member 1	Homo sapiens	118-123
26238175-7	2015	In LS180 human colon adenocarcinoma cells, 3-hydroxyflavone, quercetin, and tamarixetin increased CYP3A4, CYP3A5, and ABCB1 mRNA expression, whereas galangin and isorhamnetin increased CYP3A4 and ABCB1 but not CYP3A5 mRNA expression.	Quercetin	61-70	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	185-191
26238175-7	2015	In LS180 human colon adenocarcinoma cells, 3-hydroxyflavone, quercetin, and tamarixetin increased CYP3A4, CYP3A5, and ABCB1 mRNA expression, whereas galangin and isorhamnetin increased CYP3A4 and ABCB1 but not CYP3A5 mRNA expression.	Quercetin	61-70	ATP binding cassette subfamily B member 1	Homo sapiens	196-201
26238175-7	2015	In LS180 human colon adenocarcinoma cells, 3-hydroxyflavone, quercetin, and tamarixetin increased CYP3A4, CYP3A5, and ABCB1 mRNA expression, whereas galangin and isorhamnetin increased CYP3A4 and ABCB1 but not CYP3A5 mRNA expression.	Quercetin	61-70	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	210-216
26393568-8	2015	By contrast, in guava leaf, catechin specifically contributed to GLUT5-mediated fructose uptake inhibition, and quercetin affected both GLUT5- and GLUT2-mediated fructose uptake inhibition, resulting in the higher contribution of GLUT5.	Quercetin	112-121	solute carrier family 2 member 5	Homo sapiens	136-141
26393568-8	2015	By contrast, in guava leaf, catechin specifically contributed to GLUT5-mediated fructose uptake inhibition, and quercetin affected both GLUT5- and GLUT2-mediated fructose uptake inhibition, resulting in the higher contribution of GLUT5.	Quercetin	112-121	solute carrier family 2 member 2	Homo sapiens	147-152
26393568-8	2015	By contrast, in guava leaf, catechin specifically contributed to GLUT5-mediated fructose uptake inhibition, and quercetin affected both GLUT5- and GLUT2-mediated fructose uptake inhibition, resulting in the higher contribution of GLUT5.	Quercetin	112-121	solute carrier family 2 member 5	Homo sapiens	136-141
26393568-10	2015	Quercetin, curcumin and bisdemethoxycurcumin contributed to both GLUT5- and GLUT2-mediated fructose uptake inhibition, but the contribution to GLUT5 inhibition was higher than the contribution to GLUT2 inhibition.	Quercetin	0-9	solute carrier family 2 member 5	Homo sapiens	65-70
26393568-10	2015	Quercetin, curcumin and bisdemethoxycurcumin contributed to both GLUT5- and GLUT2-mediated fructose uptake inhibition, but the contribution to GLUT5 inhibition was higher than the contribution to GLUT2 inhibition.	Quercetin	0-9	solute carrier family 2 member 2	Homo sapiens	76-81
26393568-10	2015	Quercetin, curcumin and bisdemethoxycurcumin contributed to both GLUT5- and GLUT2-mediated fructose uptake inhibition, but the contribution to GLUT5 inhibition was higher than the contribution to GLUT2 inhibition.	Quercetin	0-9	solute carrier family 2 member 5	Homo sapiens	143-148
26393568-10	2015	Quercetin, curcumin and bisdemethoxycurcumin contributed to both GLUT5- and GLUT2-mediated fructose uptake inhibition, but the contribution to GLUT5 inhibition was higher than the contribution to GLUT2 inhibition.	Quercetin	0-9	solute carrier family 2 member 2	Homo sapiens	196-201
26388784-2	2015	Considering our previous report (Gomes et al., 2014) indicating that chronic treatment with oral low-dose quercetin (10 mg/Kg) demonstrated anti-oxidative, anti-apoptotic and renoprotective effects in the C57BL/6J model of DN, we investigated whether this flavonoid could also have beneficial effects in concurrent DN and spontaneous atherosclerosis using the apolipoprotein E-deficient mouse (apoE(-/-)).	Quercetin	106-115	apolipoprotein E	Mus musculus	360-376
26388784-2	2015	Considering our previous report (Gomes et al., 2014) indicating that chronic treatment with oral low-dose quercetin (10 mg/Kg) demonstrated anti-oxidative, anti-apoptotic and renoprotective effects in the C57BL/6J model of DN, we investigated whether this flavonoid could also have beneficial effects in concurrent DN and spontaneous atherosclerosis using the apolipoprotein E-deficient mouse (apoE(-/-)).	Quercetin	106-115	apolipoprotein E	Mus musculus	394-398
26468028-4	2015	The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-gamma content.	Quercetin	19-38	interleukin 2	Homo sapiens	87-91
26468028-4	2015	The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-gamma content.	Quercetin	19-38	interleukin 6	Homo sapiens	96-100
26468028-4	2015	The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-gamma content.	Quercetin	19-38	interferon gamma	Homo sapiens	123-132
26412426-2	2015	Quercetin was evaluated for its effects on cell numbers of neurites, neurite length, intracellular cAMP content, and Gap-43 expression in N1E-115 cells in vitro by use of microscopy, LANCE(tm) cAMP 384 kit, and Western blot analysis, respectively.	Quercetin	0-9	growth associated protein 43	Mus musculus	117-123
26412426-6	2015	In conclusion, quercetin could promote neurite growth through increasing the intracellular cAMP level and Gap-43 expression.	Quercetin	15-24	growth associated protein 43	Mus musculus	106-112
26054880-5	2015	Moreover, Que treatment inhibited the production of oxidative stress biomarkers malondialdehyde, hydrogen peroxide and 8-hydroxy-2"-deoxyguanosine, reduced the levels of proinflammatory cytokines interleukin 6, cyclooxygenase-2 and C-reactive protein, and decreased the number of TUNEL-positive cells in the liver of PFOA-treated mice.	Quercetin	10-13	prostaglandin-endoperoxide synthase 2	Mus musculus	211-227
26203745-8	2015	The quercetin group also exhibited significant declines of MMP-2 (5.1-fold of control, P &lt; 0.01), MMP-9 (2.5-fold of control, P &lt; 0.01), ICAM-1 (2.2-fold of control, P &lt; 0.01), and VCAM-1 (2.3-fold of control, P &lt; 0.01) levels in the lacrimal gland than did the PBS group.	Quercetin	4-13	matrix metallopeptidase 2	Mus musculus	59-64
26203745-8	2015	The quercetin group also exhibited significant declines of MMP-2 (5.1-fold of control, P &lt; 0.01), MMP-9 (2.5-fold of control, P &lt; 0.01), ICAM-1 (2.2-fold of control, P &lt; 0.01), and VCAM-1 (2.3-fold of control, P &lt; 0.01) levels in the lacrimal gland than did the PBS group.	Quercetin	4-13	matrix metallopeptidase 9	Mus musculus	101-106
26203745-8	2015	The quercetin group also exhibited significant declines of MMP-2 (5.1-fold of control, P &lt; 0.01), MMP-9 (2.5-fold of control, P &lt; 0.01), ICAM-1 (2.2-fold of control, P &lt; 0.01), and VCAM-1 (2.3-fold of control, P &lt; 0.01) levels in the lacrimal gland than did the PBS group.	Quercetin	4-13	intercellular adhesion molecule 1	Mus musculus	143-149
26203745-8	2015	The quercetin group also exhibited significant declines of MMP-2 (5.1-fold of control, P &lt; 0.01), MMP-9 (2.5-fold of control, P &lt; 0.01), ICAM-1 (2.2-fold of control, P &lt; 0.01), and VCAM-1 (2.3-fold of control, P &lt; 0.01) levels in the lacrimal gland than did the PBS group.	Quercetin	4-13	vascular cell adhesion molecule 1	Mus musculus	190-196
26286521-11	2015	Melatonin, quercetin and resveratrol administered diabetic rats showed an increase in CAT activities and GSH levels and a decrease in MDA levels (p &lt; 0.05, for all).	Quercetin	11-20	catalase	Rattus norvegicus	86-89
26054880-5	2015	Moreover, Que treatment inhibited the production of oxidative stress biomarkers malondialdehyde, hydrogen peroxide and 8-hydroxy-2"-deoxyguanosine, reduced the levels of proinflammatory cytokines interleukin 6, cyclooxygenase-2 and C-reactive protein, and decreased the number of TUNEL-positive cells in the liver of PFOA-treated mice.	Quercetin	10-13	C-reactive protein, pentraxin-related	Mus musculus	232-250
26116387-5	2015	Preincubation of catalase with epigallocatechin gallate and quercetin before HOCl treatment enhances the degree of catalase inhibition, whereas catechin does not affect this process.	Quercetin	60-69	catalase	Homo sapiens	17-25
26116387-5	2015	Preincubation of catalase with epigallocatechin gallate and quercetin before HOCl treatment enhances the degree of catalase inhibition, whereas catechin does not affect this process.	Quercetin	60-69	catalase	Homo sapiens	115-123
25827944-7	2015	A significant increase in carnitine palmitoyltransferase-1a activity was observed only in rats treated with the combination of resveratrol and quercetin, suggesting increased fatty acid oxidation.	Quercetin	143-152	carnitine palmitoyltransferase 1A	Rattus norvegicus	26-59
25716194-4	2015	The second specific aim was to identify potential signaling pathways in the osteoblast antioxidant response that mediate the effect of quercetin, specifically Nrf2, ERK1/2, and NFkappaB p65.	Quercetin	135-144	NFE2 like bZIP transcription factor 2	Rattus norvegicus	159-163
25716194-4	2015	The second specific aim was to identify potential signaling pathways in the osteoblast antioxidant response that mediate the effect of quercetin, specifically Nrf2, ERK1/2, and NFkappaB p65.	Quercetin	135-144	mitogen activated protein kinase 3	Rattus norvegicus	165-171
25716194-4	2015	The second specific aim was to identify potential signaling pathways in the osteoblast antioxidant response that mediate the effect of quercetin, specifically Nrf2, ERK1/2, and NFkappaB p65.	Quercetin	135-144	synaptotagmin 1	Rattus norvegicus	186-189
25988261-2	2015	To investigate the effect of acute and short-term intake of high-dose quercetin on CYP3A-mediated metabolism, 10 healthy volunteers received 7.5 mg oral midazolam without, with a single dose of 1500 mg quercetin and after 1-week supplementation with 1500 mg quercetin daily.	Quercetin	70-79	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-88
25988261-6	2015	We conclude that a single dose of quercetin would not provoke any toxic adverse events when coadministered with midazolam, whereas repeated quercetin intake can reduce systemic exposure to the orally given drug by increasing its CYP3A-catalyzed metabolism.	Quercetin	140-149	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	229-234
26218279-0	2015	Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-kappaB pathway.	Quercetin	0-9	chemokine (C-C motif) ligand 4	Mus musculus	39-43
26218279-0	2015	Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-kappaB pathway.	Quercetin	0-9	toll-like receptor 2	Mus musculus	72-78
26218279-5	2015	Our results showed that QE administration significantly inhibited CCl4-induced liver injury.	Quercetin	24-26	chemokine (C-C motif) ligand 4	Mus musculus	66-70
26617799-0	2015	Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPARgamma-ABCA1 pathway.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	100-115
26617799-4	2015	We found that quercetin induced the expression of ABCA1 in differentiated THP-1 cells, and increased the cholesterol efflux from THP-1 cell derived foam cells.	Quercetin	14-23	ATP binding cassette subfamily A member 1	Homo sapiens	50-55
26617799-6	2015	In addition, quercetin activated PPARgamma-LXRalpha pathway to upregulate ABCA1 expression through increasing protein level of PPARgamma and its transcriptional activity.	Quercetin	13-22	peroxisome proliferator activated receptor gamma	Homo sapiens	33-42
26617799-6	2015	In addition, quercetin activated PPARgamma-LXRalpha pathway to upregulate ABCA1 expression through increasing protein level of PPARgamma and its transcriptional activity.	Quercetin	13-22	ATP binding cassette subfamily A member 1	Homo sapiens	74-79
26617799-6	2015	In addition, quercetin activated PPARgamma-LXRalpha pathway to upregulate ABCA1 expression through increasing protein level of PPARgamma and its transcriptional activity.	Quercetin	13-22	peroxisome proliferator activated receptor gamma	Homo sapiens	127-136
26617799-7	2015	Inhibition of PPARgamma activity by siRNA knockdown or the addition of chemical inhibitor, GW9662, abolished quercetin induced ABCA1 expression and cholesterol efflux in THP-1 derived macrophages.	Quercetin	109-118	peroxisome proliferator activated receptor gamma	Homo sapiens	14-23
26617799-7	2015	Inhibition of PPARgamma activity by siRNA knockdown or the addition of chemical inhibitor, GW9662, abolished quercetin induced ABCA1 expression and cholesterol efflux in THP-1 derived macrophages.	Quercetin	109-118	ATP binding cassette subfamily A member 1	Homo sapiens	127-132
26617799-8	2015	Our data demonstrated that quercetin increased cholesterol efflux from macrophages through upregulating the expressions of PPARgamma and ABCA1.	Quercetin	27-36	peroxisome proliferator activated receptor gamma	Homo sapiens	123-132
26617799-8	2015	Our data demonstrated that quercetin increased cholesterol efflux from macrophages through upregulating the expressions of PPARgamma and ABCA1.	Quercetin	27-36	ATP binding cassette subfamily A member 1	Homo sapiens	137-142
26311153-12	2015	Additionally, QUE enhanced the expression of p53 and BAX in HepG2 cells.	Quercetin	14-17	tumor protein p53	Homo sapiens	45-48
26311153-12	2015	Additionally, QUE enhanced the expression of p53 and BAX in HepG2 cells.	Quercetin	14-17	BCL2 associated X, apoptosis regulator	Homo sapiens	53-56
26311153-0	2015	Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line.	Quercetin	27-36	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	58-87
26311153-0	2015	Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line.	Quercetin	27-36	tumor protein p53	Homo sapiens	139-142
26408884-8	2015	This study concludes that flavonoids primarily, quercetin ameliorates obesity by establishing a physical interaction with FTO.	Quercetin	48-57	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	122-125
26081168-7	2015	Furthermore, the six compounds reduced the production of TARC, macrophage-derived chemokine and regulated on activation normal T-cell expressed and secreted in TI-stimulated HaCaT cells; in particular, ethyl gallate and quercetin exhibited a significant dose-dependent inhibition.	Quercetin	220-229	C-C motif chemokine ligand 17	Homo sapiens	57-61
26081168-7	2015	Furthermore, the six compounds reduced the production of TARC, macrophage-derived chemokine and regulated on activation normal T-cell expressed and secreted in TI-stimulated HaCaT cells; in particular, ethyl gallate and quercetin exhibited a significant dose-dependent inhibition.	Quercetin	220-229	C-C motif chemokine ligand 22	Homo sapiens	63-91
26016839-0	2015	Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway.	Quercetin	27-36	thymoma viral proto-oncogene 1	Mus musculus	134-137
26016839-10	2015	Furthermore, the neuroprotective effects of quercetin (5, 10 mg/kg/day) in the brain were associated with an upregulation of Akt signaling.	Quercetin	44-53	AKT serine/threonine kinase 1	Rattus norvegicus	125-128
26070242-0	2015	Quercetin reduces eIF2alpha phosphorylation by GADD34 induction.	Quercetin	0-9	eukaryotic translation initiation factor 2A	Mus musculus	18-27
26070242-0	2015	Quercetin reduces eIF2alpha phosphorylation by GADD34 induction.	Quercetin	0-9	protein phosphatase 1, regulatory subunit 15A	Mus musculus	47-53
26070242-5	2015	A polyhydroxylated flavonoid, quercetin, suppressed presenilin 1 expression and Abeta secretion in autophagy-impaired cells by the induction of growth arrest and DNA damaged-inducible gene (GADD) 34, which mediates eIF2alpha dephosphorylation, leading to decreased ATF4 expression.	Quercetin	30-39	presenilin 1	Mus musculus	52-64
26070242-5	2015	A polyhydroxylated flavonoid, quercetin, suppressed presenilin 1 expression and Abeta secretion in autophagy-impaired cells by the induction of growth arrest and DNA damaged-inducible gene (GADD) 34, which mediates eIF2alpha dephosphorylation, leading to decreased ATF4 expression.	Quercetin	30-39	amyloid beta (A4) precursor protein	Mus musculus	80-85
26070242-5	2015	A polyhydroxylated flavonoid, quercetin, suppressed presenilin 1 expression and Abeta secretion in autophagy-impaired cells by the induction of growth arrest and DNA damaged-inducible gene (GADD) 34, which mediates eIF2alpha dephosphorylation, leading to decreased ATF4 expression.	Quercetin	30-39	protein phosphatase 1, regulatory subunit 15A	Mus musculus	144-198
26070242-5	2015	A polyhydroxylated flavonoid, quercetin, suppressed presenilin 1 expression and Abeta secretion in autophagy-impaired cells by the induction of growth arrest and DNA damaged-inducible gene (GADD) 34, which mediates eIF2alpha dephosphorylation, leading to decreased ATF4 expression.	Quercetin	30-39	eukaryotic translation initiation factor 2A	Mus musculus	215-224
26070242-5	2015	A polyhydroxylated flavonoid, quercetin, suppressed presenilin 1 expression and Abeta secretion in autophagy-impaired cells by the induction of growth arrest and DNA damaged-inducible gene (GADD) 34, which mediates eIF2alpha dephosphorylation, leading to decreased ATF4 expression.	Quercetin	30-39	activating transcription factor 4	Mus musculus	265-269
26070242-6	2015	GADD34 induction was observed in the brain of wild-type mice, and APP23 mice fed quercetin in their diet.	Quercetin	81-90	protein phosphatase 1, regulatory subunit 15A	Mus musculus	0-6
26070242-8	2015	These results indicate that quercetin may reduce eIF2alpha phosphorylation and ATF4 expression through GADD34 induction in the brain, leading to the improvement of memory in aged mice and the delay of deterioration in memory at the early stage of AD in AD model mice.	Quercetin	28-37	eukaryotic translation initiation factor 2A	Mus musculus	49-58
26070242-8	2015	These results indicate that quercetin may reduce eIF2alpha phosphorylation and ATF4 expression through GADD34 induction in the brain, leading to the improvement of memory in aged mice and the delay of deterioration in memory at the early stage of AD in AD model mice.	Quercetin	28-37	activating transcription factor 4	Mus musculus	79-83
26070242-8	2015	These results indicate that quercetin may reduce eIF2alpha phosphorylation and ATF4 expression through GADD34 induction in the brain, leading to the improvement of memory in aged mice and the delay of deterioration in memory at the early stage of AD in AD model mice.	Quercetin	28-37	protein phosphatase 1, regulatory subunit 15A	Mus musculus	103-109
26151815-0	2015	Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy.	Quercetin	0-9	CREB regulated transcription coactivator 1	Mus musculus	23-29
26151815-0	2015	Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy.	Quercetin	0-9	ribosomal protein S6 kinase B1	Rattus norvegicus	30-36
26151815-5	2015	Quercetin effectively ameliorated the high glucose-induced EMT of HK-2 and NRK-52E cells and inhibited the activation of mTORC1/p70S6K.	Quercetin	0-9	hexokinase 2	Rattus norvegicus	66-70
26357463-10	2015	Src inhibitors, including PP2, PP1, Saracatinib, and Quercetin, partially inhibited LPS-induced phosphorylation of Cav-1.	Quercetin	53-62	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	0-3
26151815-5	2015	Quercetin effectively ameliorated the high glucose-induced EMT of HK-2 and NRK-52E cells and inhibited the activation of mTORC1/p70S6K.	Quercetin	0-9	CREB regulated transcription coactivator 1	Mus musculus	121-127
26151815-5	2015	Quercetin effectively ameliorated the high glucose-induced EMT of HK-2 and NRK-52E cells and inhibited the activation of mTORC1/p70S6K.	Quercetin	0-9	ribosomal protein S6 kinase B1	Rattus norvegicus	128-134
26151815-8	2015	Treatment with quercetin alleviated the decline in renal function, and the progression of renal fibrosis and inhibited mTORC1/p70S6K activation in the diabetic renal cortex.	Quercetin	15-24	CREB regulated transcription coactivator 1	Mus musculus	119-125
26151815-8	2015	Treatment with quercetin alleviated the decline in renal function, and the progression of renal fibrosis and inhibited mTORC1/p70S6K activation in the diabetic renal cortex.	Quercetin	15-24	ribosomal protein S6 kinase B1	Rattus norvegicus	126-132
26151815-10	2015	The results revealed that the elevated expression of snail and twist in HK-2 and NRK-52E cells cultured under high glucose and in the renal cortex of diabetic rats was inhibited by quercetin.	Quercetin	181-190	hexokinase 2	Rattus norvegicus	72-76
26151815-11	2015	These results demonstrated that quercetin ameliorates the EMT of HK-2 and NRK-52E cells induced by high glucose and renal fibrosis induced by diabetes, and these effects have been associated with the inhibition of the two transcriptional factors (snail and twist) and the activation of mTORC1/p70S6K.	Quercetin	32-41	hexokinase 2	Rattus norvegicus	65-69
26151815-11	2015	These results demonstrated that quercetin ameliorates the EMT of HK-2 and NRK-52E cells induced by high glucose and renal fibrosis induced by diabetes, and these effects have been associated with the inhibition of the two transcriptional factors (snail and twist) and the activation of mTORC1/p70S6K.	Quercetin	32-41	CREB regulated transcription coactivator 1	Mus musculus	286-292
26151815-11	2015	These results demonstrated that quercetin ameliorates the EMT of HK-2 and NRK-52E cells induced by high glucose and renal fibrosis induced by diabetes, and these effects have been associated with the inhibition of the two transcriptional factors (snail and twist) and the activation of mTORC1/p70S6K.	Quercetin	32-41	ribosomal protein S6 kinase B1	Rattus norvegicus	293-299
26170247-3	2015	We investigated the possibility that okra (Abelmoschus esculentus) and quercetin could mitigate this risk factor by examining its effect on AD-associated cellular events in HFE stably expressing SH-SY5Y cells.	Quercetin	71-80	homeostatic iron regulator	Homo sapiens	173-176
26357463-10	2015	Src inhibitors, including PP2, PP1, Saracatinib, and Quercetin, partially inhibited LPS-induced phosphorylation of Cav-1.	Quercetin	53-62	caveolin 1	Rattus norvegicus	115-120
25881548-0	2015	The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.	Quercetin	113-122	nucleoporin 62	Homo sapiens	19-22
26349981-11	2015	Furthermore, the therapeutic response of Quercetin in the combination of miR-143 was evaluated by MTT, Hochest and western blot, results suggesting that the chemosensitivity of Quercetin was enhanced when in combination with miR-143 in AGS/MNK28 cells.	Quercetin	177-186	microRNA 143	Homo sapiens	73-80
26349981-11	2015	Furthermore, the therapeutic response of Quercetin in the combination of miR-143 was evaluated by MTT, Hochest and western blot, results suggesting that the chemosensitivity of Quercetin was enhanced when in combination with miR-143 in AGS/MNK28 cells.	Quercetin	177-186	microRNA 143	Homo sapiens	225-232
26349981-12	2015	In conclusion, we determined miR-143 as a potent inhibitor of autophagy via targeting GABARAPL1 and miR-143 could improve the efficacy of Quercetin though autophagy inhibition in GC cell lines, thus representing a novel potential therapeutic target for gastric cancer.	Quercetin	138-147	microRNA 143	Homo sapiens	29-36
26349981-12	2015	In conclusion, we determined miR-143 as a potent inhibitor of autophagy via targeting GABARAPL1 and miR-143 could improve the efficacy of Quercetin though autophagy inhibition in GC cell lines, thus representing a novel potential therapeutic target for gastric cancer.	Quercetin	138-147	GABA type A receptor associated protein like 1	Homo sapiens	86-95
26349981-12	2015	In conclusion, we determined miR-143 as a potent inhibitor of autophagy via targeting GABARAPL1 and miR-143 could improve the efficacy of Quercetin though autophagy inhibition in GC cell lines, thus representing a novel potential therapeutic target for gastric cancer.	Quercetin	138-147	microRNA 143	Homo sapiens	100-107
25881548-9	2015	JNK inhibitor SP600125 and JNK siRNA both reduced quercetin-induced hepatoprotection.	Quercetin	50-59	mitogen-activated protein kinase 8	Homo sapiens	0-3
25881548-9	2015	JNK inhibitor SP600125 and JNK siRNA both reduced quercetin-induced hepatoprotection.	Quercetin	50-59	mitogen-activated protein kinase 8	Homo sapiens	27-30
26249340-3	2015	Here, structures of TTR in complex with three natural polyphenols (pterostilbene, quercetin and apigenin) have been determined, in which this asymmetry manifests itself as the presence of a main binding site with clear ligand occupancy and related electron density and a second minor site with a much lower ligand occupancy.	Quercetin	82-91	transthyretin	Homo sapiens	20-23
26249340-9	2015	Competition binding assays carried out in solution revealed the presence of a preferential binding site in TTR for the polyphenols pterostilbene and quercetin that was different from the preferential binding site for T4.	Quercetin	149-158	transthyretin	Homo sapiens	107-110
26349981-0	2015	MicroRNA-143 enhances chemosensitivity of Quercetin through autophagy inhibition via target GABARAPL1 in gastric cancer cells.	Quercetin	42-51	GABA type A receptor associated protein like 1	Homo sapiens	92-101
26349981-11	2015	Furthermore, the therapeutic response of Quercetin in the combination of miR-143 was evaluated by MTT, Hochest and western blot, results suggesting that the chemosensitivity of Quercetin was enhanced when in combination with miR-143 in AGS/MNK28 cells.	Quercetin	41-50	microRNA 143	Homo sapiens	73-80
26349981-11	2015	Furthermore, the therapeutic response of Quercetin in the combination of miR-143 was evaluated by MTT, Hochest and western blot, results suggesting that the chemosensitivity of Quercetin was enhanced when in combination with miR-143 in AGS/MNK28 cells.	Quercetin	41-50	microRNA 143	Homo sapiens	225-232
25957741-0	2015	Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	107-111
25957741-0	2015	Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway.	Quercetin	0-9	heme oxygenase 1	Mus musculus	112-116
25957741-0	2015	Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway.	Quercetin	0-9	mitogen-activated protein kinase 14	Mus musculus	121-124
25957741-0	2015	Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway.	Quercetin	0-9	signal transducer and activator of transcription 1	Mus musculus	125-130
25881548-10	2015	SP600125 and JNK siRNA decreased the increased p62 expression induced by quercetin.	Quercetin	73-82	mitogen-activated protein kinase 8	Homo sapiens	13-16
25881548-10	2015	SP600125 and JNK siRNA decreased the increased p62 expression induced by quercetin.	Quercetin	73-82	nucleoporin 62	Homo sapiens	47-50
25881548-11	2015	In addition, SP600125 also decreased the increased mRNA and protein expression of GCLC, GCLM, and HO-1 induced by quercetin.	Quercetin	114-123	glutamate-cysteine ligase catalytic subunit	Homo sapiens	82-86
25957741-0	2015	Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	131-140
25881548-11	2015	In addition, SP600125 also decreased the increased mRNA and protein expression of GCLC, GCLM, and HO-1 induced by quercetin.	Quercetin	114-123	glutamate-cysteine ligase modifier subunit	Homo sapiens	88-92
25881548-11	2015	In addition, SP600125 also decreased the increased mRNA and protein expression of GCLC, GCLM, and HO-1 induced by quercetin.	Quercetin	114-123	heme oxygenase 1	Homo sapiens	98-102
25881548-12	2015	Taken together, our present study demonstrates that quercetin prevents hepatotoxicity by inducing p62 expression, inhibiting the binding of Keap1 to Nrf2, and thus leading to the increased expression of antioxidative genes dependent on Nrf2.	Quercetin	52-61	nucleoporin 62	Homo sapiens	98-101
25881548-12	2015	Taken together, our present study demonstrates that quercetin prevents hepatotoxicity by inducing p62 expression, inhibiting the binding of Keap1 to Nrf2, and thus leading to the increased expression of antioxidative genes dependent on Nrf2.	Quercetin	52-61	kelch like ECH associated protein 1	Homo sapiens	140-145
25881548-12	2015	Taken together, our present study demonstrates that quercetin prevents hepatotoxicity by inducing p62 expression, inhibiting the binding of Keap1 to Nrf2, and thus leading to the increased expression of antioxidative genes dependent on Nrf2.	Quercetin	52-61	NFE2 like bZIP transcription factor 2	Homo sapiens	149-153
25957741-6	2015	In exploring the underlying mechanisms of quercetin action, we found that quercetin decreased total DNA methyltransferases (DNMTs) activity and DNA methylation level of the NF-E2 related factor 2 (Nrf2) DNA in livers of nickel-treated mice.	Quercetin	42-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	173-195
25957741-6	2015	In exploring the underlying mechanisms of quercetin action, we found that quercetin decreased total DNA methyltransferases (DNMTs) activity and DNA methylation level of the NF-E2 related factor 2 (Nrf2) DNA in livers of nickel-treated mice.	Quercetin	42-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	197-201
25957741-6	2015	In exploring the underlying mechanisms of quercetin action, we found that quercetin decreased total DNA methyltransferases (DNMTs) activity and DNA methylation level of the NF-E2 related factor 2 (Nrf2) DNA in livers of nickel-treated mice.	Quercetin	74-83	nuclear factor, erythroid derived 2, like 2	Mus musculus	173-195
25957741-6	2015	In exploring the underlying mechanisms of quercetin action, we found that quercetin decreased total DNA methyltransferases (DNMTs) activity and DNA methylation level of the NF-E2 related factor 2 (Nrf2) DNA in livers of nickel-treated mice.	Quercetin	74-83	nuclear factor, erythroid derived 2, like 2	Mus musculus	197-201
25957741-7	2015	Quercetin also induced Nrf2 nuclear translocation and heme oxygenase-1 (HO-1) activity.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
25957741-7	2015	Quercetin also induced Nrf2 nuclear translocation and heme oxygenase-1 (HO-1) activity.	Quercetin	0-9	heme oxygenase 1	Mus musculus	54-70
25881548-12	2015	Taken together, our present study demonstrates that quercetin prevents hepatotoxicity by inducing p62 expression, inhibiting the binding of Keap1 to Nrf2, and thus leading to the increased expression of antioxidative genes dependent on Nrf2.	Quercetin	52-61	NFE2 like bZIP transcription factor 2	Homo sapiens	236-240
25957741-7	2015	Quercetin also induced Nrf2 nuclear translocation and heme oxygenase-1 (HO-1) activity.	Quercetin	0-9	heme oxygenase 1	Mus musculus	72-76
25881548-0	2015	The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.	Quercetin	113-122	mitogen-activated protein kinase 8	Homo sapiens	70-73
25957741-8	2015	Moreover, quercetin decreased production of pro-inflammatory markers including TNF-alpha, IL-1beta and iNOS.	Quercetin	10-19	tumor necrosis factor	Mus musculus	79-88
25957741-8	2015	Moreover, quercetin decreased production of pro-inflammatory markers including TNF-alpha, IL-1beta and iNOS.	Quercetin	10-19	interleukin 1 beta	Mus musculus	90-98
25881548-2	2015	The present study aims to investigate the critical role of the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidative signaling pathway in the protection of quercetin against hepatotoxicity.	Quercetin	167-176	NFE2 like bZIP transcription factor 2	Homo sapiens	63-106
25957741-8	2015	Moreover, quercetin decreased production of pro-inflammatory markers including TNF-alpha, IL-1beta and iNOS.	Quercetin	10-19	nitric oxide synthase 2, inducible	Mus musculus	103-107
25881548-2	2015	The present study aims to investigate the critical role of the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidative signaling pathway in the protection of quercetin against hepatotoxicity.	Quercetin	167-176	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
25881548-3	2015	Quercetin prevented the cytotoxicity induced by a variety of hepatotoxicants including clivorine (Cliv), acetaminophen (APAP), ethanol, carbon tetrachloride (CCl4), and toosendanin (TSN) in human normal liver L-02 cells.	Quercetin	0-9	C-C motif chemokine ligand 4	Homo sapiens	158-162
25957741-9	2015	Quercetin significantly inhibited the p38 and signal transducer and activator of transcription 1 (STAT1) activation, which in turn inactivated NF-kappaB and the inflammatory cytokines in livers of the nickel-treated mice.	Quercetin	0-9	mitogen-activated protein kinase 14	Mus musculus	38-41
25957741-9	2015	Quercetin significantly inhibited the p38 and signal transducer and activator of transcription 1 (STAT1) activation, which in turn inactivated NF-kappaB and the inflammatory cytokines in livers of the nickel-treated mice.	Quercetin	0-9	signal transducer and activator of transcription 1	Mus musculus	46-96
25881548-4	2015	Quercetin induced the nuclear translocation of Nrf2, along with the increased expression of the antioxidant responsive element (ARE)-dependent genes like catalytic or modify subunit of glutamate-cysteine ligase (GCLC/GCLM), and heme oxygenase-1 (HO-1).	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
25957741-9	2015	Quercetin significantly inhibited the p38 and signal transducer and activator of transcription 1 (STAT1) activation, which in turn inactivated NF-kappaB and the inflammatory cytokines in livers of the nickel-treated mice.	Quercetin	0-9	signal transducer and activator of transcription 1	Mus musculus	98-103
25881548-4	2015	Quercetin induced the nuclear translocation of Nrf2, along with the increased expression of the antioxidant responsive element (ARE)-dependent genes like catalytic or modify subunit of glutamate-cysteine ligase (GCLC/GCLM), and heme oxygenase-1 (HO-1).	Quercetin	0-9	glutamate-cysteine ligase catalytic subunit	Homo sapiens	212-216
25957741-9	2015	Quercetin significantly inhibited the p38 and signal transducer and activator of transcription 1 (STAT1) activation, which in turn inactivated NF-kappaB and the inflammatory cytokines in livers of the nickel-treated mice.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
25957741-10	2015	In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway.	Quercetin	93-102	nuclear factor, erythroid derived 2, like 2	Mus musculus	146-150
26156396-4	2015	Tentative identification of significantly differing metabolites highlighted the presence of carbohydrate derivatives or conjugates (3-phenylpropyl glucosinolate and dTDP-D-mycaminose) in the quercetin group.	Quercetin	191-200	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	165-169
25881548-4	2015	Quercetin induced the nuclear translocation of Nrf2, along with the increased expression of the antioxidant responsive element (ARE)-dependent genes like catalytic or modify subunit of glutamate-cysteine ligase (GCLC/GCLM), and heme oxygenase-1 (HO-1).	Quercetin	0-9	glutamate-cysteine ligase modifier subunit	Homo sapiens	217-221
25957741-10	2015	In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway.	Quercetin	93-102	heme oxygenase 1	Mus musculus	151-155
25957741-10	2015	In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway.	Quercetin	93-102	mitogen-activated protein kinase 14	Mus musculus	160-163
25957741-10	2015	In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway.	Quercetin	93-102	signal transducer and activator of transcription 1	Mus musculus	164-169
25957741-10	2015	In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway.	Quercetin	93-102	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	170-179
25881548-4	2015	Quercetin induced the nuclear translocation of Nrf2, along with the increased expression of the antioxidant responsive element (ARE)-dependent genes like catalytic or modify subunit of glutamate-cysteine ligase (GCLC/GCLM), and heme oxygenase-1 (HO-1).	Quercetin	0-9	heme oxygenase 1	Homo sapiens	228-244
25881548-4	2015	Quercetin induced the nuclear translocation of Nrf2, along with the increased expression of the antioxidant responsive element (ARE)-dependent genes like catalytic or modify subunit of glutamate-cysteine ligase (GCLC/GCLM), and heme oxygenase-1 (HO-1).	Quercetin	0-9	heme oxygenase 1	Homo sapiens	246-250
25881548-5	2015	In addition, the HO-1 inhibitor zinc protoporphyrin (ZnPP) and the GCL inhibitor L-buthionine-(S,R)-sulfoximine (BSO) both reduced the hepatoprotection induced by quercetin.	Quercetin	163-172	heme oxygenase 1	Homo sapiens	17-21
25881548-5	2015	In addition, the HO-1 inhibitor zinc protoporphyrin (ZnPP) and the GCL inhibitor L-buthionine-(S,R)-sulfoximine (BSO) both reduced the hepatoprotection induced by quercetin.	Quercetin	163-172	glutamate-cysteine ligase catalytic subunit	Homo sapiens	67-70
25881548-6	2015	Quercetin had no effect on kelch-like ECH-associated protein-1(Keap1) expression, but molecular docking results indicated the potential interaction of quercetin with the Nrf2-binding site in Keap1 protein.	Quercetin	151-160	NFE2 like bZIP transcription factor 2	Homo sapiens	170-174
25881548-6	2015	Quercetin had no effect on kelch-like ECH-associated protein-1(Keap1) expression, but molecular docking results indicated the potential interaction of quercetin with the Nrf2-binding site in Keap1 protein.	Quercetin	151-160	kelch like ECH associated protein 1	Homo sapiens	191-196
25881548-7	2015	Quercetin increased the expression of p62, and p62 siRNA decreased quercetin-induced hepatoprotection.	Quercetin	0-9	nucleoporin 62	Homo sapiens	38-41
25881548-7	2015	Quercetin increased the expression of p62, and p62 siRNA decreased quercetin-induced hepatoprotection.	Quercetin	67-76	nucleoporin 62	Homo sapiens	47-50
25881548-8	2015	Quercetin induced the activation of c-Jun N-terminal kinase (JNK) in hepatocytes.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	36-59
25881548-8	2015	Quercetin induced the activation of c-Jun N-terminal kinase (JNK) in hepatocytes.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	61-64
25937243-0	2015	Quercetin induces the apoptosis of human ovarian carcinoma cells by upregulating the expression of microRNA-145.	Quercetin	0-9	microRNA 145	Homo sapiens	99-111
26557974-8	2015	pioglitazone and hydroxy citric acid, the group treated with quercetin showed significant decrease in the levels of hyaluronic acid and leptin and significant decrease in adiponectin levels compared with that of experimentally induced NASH NASH group, offering maximum protection against NASH.	Quercetin	61-70	leptin	Rattus norvegicus	136-142
26557974-8	2015	pioglitazone and hydroxy citric acid, the group treated with quercetin showed significant decrease in the levels of hyaluronic acid and leptin and significant decrease in adiponectin levels compared with that of experimentally induced NASH NASH group, offering maximum protection against NASH.	Quercetin	61-70	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	171-182
26557974-9	2015	CONCLUSION: Considering our findings, it could be concluded that quercetin may offer maximum protection against NASH by significantly increasing the levels of adiponectin, when compared to pioglitazone and hydroxy citric acid.	Quercetin	65-74	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	159-170
25937243-3	2015	Therefore, the present study investigated the effect of quercetin on the expression of miR-145 in SKOV-3 and A2780 human ovarian cancer cell lines.	Quercetin	56-65	microRNA 145	Homo sapiens	87-94
25937243-4	2015	The results revealed that the expression levels of cleaved caspase-3 in the SKOV-3 and A2780 cells were significantly increased following treatment to induce overexpression of miR-145 compared with treatment with quercetin alone (P&lt;0.01).	Quercetin	213-222	microRNA 145	Homo sapiens	176-183
26434118-0	2015	Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines.	Quercetin	10-19	proliferating cell nuclear antigen	Homo sapiens	38-44
26434118-4	2015	Quercetin (10-50 muM) caused evident changes in the distribution of cell cycle phases in the CDDP-resistant SKOV3/CDDP ovarian cell line.	Quercetin	0-9	latexin	Homo sapiens	17-20
26434118-5	2015	The levels of cyclin D1 and cyclin B1 were determined by means of Western blot in all cell lines incubated with quercetin (50 muM) for 48 hours.	Quercetin	112-121	cyclin D1	Homo sapiens	14-23
26434118-5	2015	The levels of cyclin D1 and cyclin B1 were determined by means of Western blot in all cell lines incubated with quercetin (50 muM) for 48 hours.	Quercetin	112-121	latexin	Homo sapiens	126-129
26434118-6	2015	The cyclin D1 expression was significantly decreased following the treatment with quercetin in SKOV3 and U2OSPt cells, but not in SKOV3/CDDP and U2OS cells.	Quercetin	82-91	cyclin D1	Homo sapiens	4-13
26434118-7	2015	The reduction of cyclin D1 level could be linked to the G1/S phase alteration found in quercetin-treated cells.	Quercetin	87-96	cyclin D1	Homo sapiens	17-26
26268473-6	2015	Quercetin was shown to significantly reduce Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg), secretion and HBV genomic DNA levels in both cell lines.	Quercetin	0-9	capsid protein;pre-capsid protein	Hepatitis B virus	84-113
26099270-6	2015	Genetic and biochemical evidence indicated that low-sulfur Pox are the result of peroxidase-catalyzed oxidation of quercetin in roots grown under sulfur-depleted conditions.	Quercetin	115-124	peroxidase	Arabidopsis thaliana	81-91
26197788-7	2015	Unfortunately, all of the tested derivatives rendered lower inhibitory potency than quercetin towards 15-LOX-1.	Quercetin	84-93	arachidonate 15-lipoxygenase	Homo sapiens	102-110
26148186-2	2015	Quercetin (Qu), the most widely consumed dietary bioflavonoid and well known inhibitor of phosphoinositide 3-kinase (PI3K) and mitogen activated protein (MAP) kinase signalling, has been reported to be chemopreventive in several forms of non-melanoma skin cancers.	Quercetin	0-9	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	90-115
26141765-0	2015	Quercetin-POM (pivaloxymethyl) conjugates: Modulatory activity for P-glycoprotein-based multidrug resistance.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	67-81
26148186-5	2015	Promotion of UVB-induced cell death by quercetin was further revealed by cleavage of chromosomal DNA, caspase activation, poly (ADP) ribose polymerase (PARP) cleavage, and an increase in sub-G1 cells.	Quercetin	39-48	poly (ADP-ribose) polymerase family, member 1	Mus musculus	152-156
26148186-6	2015	Quercetin markedly attenuated MEK-ERK signalling, influenced PI3K/Akt pathway, and potentially enhanced the UVB-induced NF-kappaB nuclear translocation.	Quercetin	0-9	midkine	Mus musculus	30-33
26148186-6	2015	Quercetin markedly attenuated MEK-ERK signalling, influenced PI3K/Akt pathway, and potentially enhanced the UVB-induced NF-kappaB nuclear translocation.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	66-69
26148186-7	2015	Furthermore, combined UVB and quercetin treatment decreased the ratio of Bcl-2 to that of Bax, and upregulated the expression of Bim and apoptosis inducing factor (AIF).	Quercetin	30-39	B cell leukemia/lymphoma 2	Mus musculus	73-78
26148186-7	2015	Furthermore, combined UVB and quercetin treatment decreased the ratio of Bcl-2 to that of Bax, and upregulated the expression of Bim and apoptosis inducing factor (AIF).	Quercetin	30-39	BCL2-associated X protein	Mus musculus	90-93
26148186-7	2015	Furthermore, combined UVB and quercetin treatment decreased the ratio of Bcl-2 to that of Bax, and upregulated the expression of Bim and apoptosis inducing factor (AIF).	Quercetin	30-39	BCL2-like 11 (apoptosis facilitator)	Mus musculus	129-132
26148186-7	2015	Furthermore, combined UVB and quercetin treatment decreased the ratio of Bcl-2 to that of Bax, and upregulated the expression of Bim and apoptosis inducing factor (AIF).	Quercetin	30-39	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	137-162
26148186-7	2015	Furthermore, combined UVB and quercetin treatment decreased the ratio of Bcl-2 to that of Bax, and upregulated the expression of Bim and apoptosis inducing factor (AIF).	Quercetin	30-39	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	164-167
25138434-0	2015	Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	87-90
25138434-3	2015	Results from Western blot and flow cytometric assays revealed that quercetin significantly induced caspase-8, caspase-9, and caspase-3 activation, poly ADP-ribose polymerase (PARP) cleavage, and mitochondrial membrane depolarization in HL-60 AML cells.	Quercetin	67-76	caspase 8	Homo sapiens	99-108
25138434-3	2015	Results from Western blot and flow cytometric assays revealed that quercetin significantly induced caspase-8, caspase-9, and caspase-3 activation, poly ADP-ribose polymerase (PARP) cleavage, and mitochondrial membrane depolarization in HL-60 AML cells.	Quercetin	67-76	caspase 9	Homo sapiens	110-119
25138434-3	2015	Results from Western blot and flow cytometric assays revealed that quercetin significantly induced caspase-8, caspase-9, and caspase-3 activation, poly ADP-ribose polymerase (PARP) cleavage, and mitochondrial membrane depolarization in HL-60 AML cells.	Quercetin	67-76	caspase 3	Homo sapiens	125-134
25138434-3	2015	Results from Western blot and flow cytometric assays revealed that quercetin significantly induced caspase-8, caspase-9, and caspase-3 activation, poly ADP-ribose polymerase (PARP) cleavage, and mitochondrial membrane depolarization in HL-60 AML cells.	Quercetin	67-76	poly(ADP-ribose) polymerase 1	Homo sapiens	147-173
25138434-3	2015	Results from Western blot and flow cytometric assays revealed that quercetin significantly induced caspase-8, caspase-9, and caspase-3 activation, poly ADP-ribose polymerase (PARP) cleavage, and mitochondrial membrane depolarization in HL-60 AML cells.	Quercetin	67-76	poly(ADP-ribose) polymerase 1	Homo sapiens	175-179
25138434-4	2015	The induction of PARP cleavage by quercetin was also observed in other AML cell lines: THP-1, MV4-11, and U937.	Quercetin	34-43	poly(ADP-ribose) polymerase 1	Homo sapiens	17-21
25138434-5	2015	Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis.	Quercetin	40-49	mitogen-activated protein kinase 1	Homo sapiens	82-119
25138434-5	2015	Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis.	Quercetin	40-49	mitogen-activated protein kinase 1	Homo sapiens	121-124
25138434-5	2015	Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis.	Quercetin	40-49	mitogen-activated protein kinase 1	Homo sapiens	145-148
25138434-5	2015	Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis.	Quercetin	40-49	mitogen-activated protein kinase 1	Homo sapiens	145-148
25138434-5	2015	Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis.	Quercetin	193-202	mitogen-activated protein kinase 1	Homo sapiens	82-119
25138434-5	2015	Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis.	Quercetin	193-202	mitogen-activated protein kinase 1	Homo sapiens	121-124
25138434-5	2015	Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis.	Quercetin	193-202	mitogen-activated protein kinase 1	Homo sapiens	145-148
25138434-5	2015	Moreover, treatment of HL-60 cells with quercetin induced sustained activation of extracellular signal-regulated kinase (ERK), and inhibition of ERK by an ERK inhibitor significantly abolished quercetin-induced cell apoptosis.	Quercetin	193-202	mitogen-activated protein kinase 1	Homo sapiens	145-148
25138434-7	2015	Moreover, both N-acetylcysteine and the superoxide dismutase mimetic, MnTBAP, reversed quercetin-induced intracellular reactive oxygen species production, ERK activation, and subsequent cell death.	Quercetin	87-96	mitogen-activated protein kinase 1	Homo sapiens	155-158
25138434-8	2015	The in vivo xenograft mice experiments revealed that quercetin significantly reduced tumor growth through inducing intratumoral oxidative stress while activating the ERK pathway and subsequent cell apoptosis in mice with HL-60 tumor xenografts.	Quercetin	53-62	mitogen-activated protein kinase 1	Mus musculus	166-169
26154585-6	2015	Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM).	Quercetin	123-132	sucrase-isomaltase	Homo sapiens	9-26
25138434-9	2015	In conclusions, our results indicated that quercetin induced cell death of HL-60 cells in vitro and in vivo through induction of intracellular oxidative stress following activation of an ERK-mediated apoptosis pathway.	Quercetin	43-52	mitogen-activated protein kinase 1	Homo sapiens	187-190
25796361-12	2015	Activation of NRF2 with quercetin or by oxidative stress reduced expression of ITPR3 and calcium signaling in NHC cells; quercetin also reduced secretion by bile duct units isolated from rats.	Quercetin	24-33	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
25796361-12	2015	Activation of NRF2 with quercetin or by oxidative stress reduced expression of ITPR3 and calcium signaling in NHC cells; quercetin also reduced secretion by bile duct units isolated from rats.	Quercetin	24-33	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	79-84
25796361-12	2015	Activation of NRF2 with quercetin or by oxidative stress reduced expression of ITPR3 and calcium signaling in NHC cells; quercetin also reduced secretion by bile duct units isolated from rats.	Quercetin	121-130	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
26022682-6	2015	Mesenteric adipose tissue weight and serum leptin levels were significantly lowered by quercetin, hesperetin and anthocyanins.	Quercetin	87-96	leptin	Mus musculus	43-49
25796361-13	2015	Knockdown of NRF2 with small interfering RNAs restored expression and function of ITPR3 in NHC cells incubated with quercetin.	Quercetin	116-125	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
25796361-13	2015	Knockdown of NRF2 with small interfering RNAs restored expression and function of ITPR3 in NHC cells incubated with quercetin.	Quercetin	116-125	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	82-87
26139922-2	2015	The present study was aimed to compare the inhibitory potential of selected common dietary bioactive molecules (Gallic acid, Ellagic acid, beta-Sitosterol, Stigmasterol, Quercetin and Rutin) on CYP3A4 and CYP2D6 to assess safety through its inhibitory potency and to predict interaction potential with co-administered drugs.	Quercetin	170-179	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	205-211
26351552-0	2015	Quercetin induces cell cycle arrest and apoptosis in CD133(+) cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin.	Quercetin	0-9	prominin 1	Homo sapiens	53-58
26139922-4	2015	CYP450 concentration of the rat liver microsome was found to be 0.474 nmol/mg protein, quercetin in DMSO has shown maximum inhibition on CYP450 (51.02 +- 1.24 %) but less when compared with positive control (79.02 +- 1.61 %).	Quercetin	87-96	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-6
26139922-4	2015	CYP450 concentration of the rat liver microsome was found to be 0.474 nmol/mg protein, quercetin in DMSO has shown maximum inhibition on CYP450 (51.02 +- 1.24 %) but less when compared with positive control (79.02 +- 1.61 %).	Quercetin	87-96	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	137-143
26139922-5	2015	In high throughput fluorometric assay, IC50 value of quercetin (49.08 +- 1.02-54.36 +- 0.85 mug/ml) and gallic acid (78.46 +- 1.32-83.84 +- 1.06 mug/ml) was lower than other bioactive compounds on CYP3A4 and CYP2D6 respectively but it was higher than positive controls (06.28 +- 1.76-07.74 +- 1.32 mug/ml).	Quercetin	53-62	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	208-214
26139922-6	2015	In comparison of in vitro inhibitory potential on CYP3A4 and CYP2D6, consumption of food or herbal or dietary supplements containing quercetin and gallic acid without any limitation should be carefully considered when narrow therapeutic drugs are administered together.	Quercetin	133-142	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	61-67
25972527-9	2015	Quercetin changed Deltaquercetin - Deltaplacebo for sE-selectin by -7.4 ng/mL (95% CI: -14.3, -0.56; P = 0.03), that for IL-1beta by -0.23 pg/mL (95% CI: -0.40, -0.06; P = 0.009), and that for the z score for inflammation by -0.33 (95% CI: -0.60, -0.05; P = 0.02).	Quercetin	0-9	interleukin 1 beta	Homo sapiens	121-129
26062553-0	2015	Quercetin Enhances Cisplatin Sensitivity of Human Osteosarcoma Cells by Modulating microRNA-217-KRAS Axis.	Quercetin	0-9	KRAS proto-oncogene, GTPase	Homo sapiens	96-100
26198964-1	2015	OBJECTIVE: To evaluate the protective effect of quercetin against lipopolysaccharide (LPS)-induced cardiac injury in mice.	Quercetin	48-57	toll-like receptor 4	Mus musculus	86-89
26198964-5	2015	RESULTS: Quercetin pretreatment significantly improved the cardiac function of LPS-challenged mice (P&lt;0.05), and attenuated LPS-induced increment in myocardial iNOS expression and decrement in eNOS level.	Quercetin	9-18	toll-like receptor 4	Mus musculus	79-82
26198964-5	2015	RESULTS: Quercetin pretreatment significantly improved the cardiac function of LPS-challenged mice (P&lt;0.05), and attenuated LPS-induced increment in myocardial iNOS expression and decrement in eNOS level.	Quercetin	9-18	toll-like receptor 4	Mus musculus	127-130
26198964-5	2015	RESULTS: Quercetin pretreatment significantly improved the cardiac function of LPS-challenged mice (P&lt;0.05), and attenuated LPS-induced increment in myocardial iNOS expression and decrement in eNOS level.	Quercetin	9-18	nitric oxide synthase 2, inducible	Mus musculus	163-167
26198964-6	2015	LPS significantly increased the myocardial Bax expression and slightly decreased Bcl-2 expression; quercetin pretreatment decreased Bax expression to the control level and significantly lowered Bax/Bcl-2 ratio as compared with the LPS group.	Quercetin	99-108	BCL2-associated X protein	Mus musculus	132-135
26198964-6	2015	LPS significantly increased the myocardial Bax expression and slightly decreased Bcl-2 expression; quercetin pretreatment decreased Bax expression to the control level and significantly lowered Bax/Bcl-2 ratio as compared with the LPS group.	Quercetin	99-108	BCL2-associated X protein	Mus musculus	132-135
26198964-6	2015	LPS significantly increased the myocardial Bax expression and slightly decreased Bcl-2 expression; quercetin pretreatment decreased Bax expression to the control level and significantly lowered Bax/Bcl-2 ratio as compared with the LPS group.	Quercetin	99-108	B cell leukemia/lymphoma 2	Mus musculus	198-203
26198964-8	2015	The 5-day survival rate of LPS-treated mice was 10%, which was increased to 45% in quercetin- pretreated mice (P&lt;0.05).	Quercetin	83-92	toll-like receptor 4	Mus musculus	27-30
26198964-9	2015	CONCLUSION: Quercetin can alleviate LPS-induced cardiac dysfunctions in mice to increase their survival rate following LPS challenge.	Quercetin	12-21	toll-like receptor 4	Mus musculus	36-39
26198964-9	2015	CONCLUSION: Quercetin can alleviate LPS-induced cardiac dysfunctions in mice to increase their survival rate following LPS challenge.	Quercetin	12-21	toll-like receptor 4	Mus musculus	119-122
26330835-3	2015	However, the influence of dietary factors such as quercetin on alpha-synuclein was rarely studied.	Quercetin	50-59	synuclein alpha	Rattus norvegicus	63-78
26330835-4	2015	Herein we aimed to study the neuroprotective role of quercetin against various toxins affecting apoptosis, autophagy and aggresome, and the role of quercetin on alpha-synuclein expression.	Quercetin	148-157	synuclein alpha	Rattus norvegicus	161-176
26330835-13	2015	Quercetin treatment increased alpha-synuclein expression.	Quercetin	0-9	synuclein alpha	Rattus norvegicus	30-45
26330835-16	2015	Because alpha-synuclein expression is increased by quercetin, the role of quercetin as an environmental factor in Parkinson"s disease pathogenesis needs further investigation.	Quercetin	51-60	synuclein alpha	Rattus norvegicus	8-23
25997470-0	2015	Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	42-47
25997470-3	2015	We investigated whether quercetin enhances TRAIL-induced tumor cell death and the possible mechanism in human lung cancer cells.	Quercetin	24-33	TNF superfamily member 10	Homo sapiens	43-48
25997470-4	2015	We identified that quercetin markedly enhanced TRAIL-mediated lung cancer cell death.	Quercetin	19-28	TNF superfamily member 10	Homo sapiens	47-52
25997470-5	2015	Quercetin treatment dose-dependently decreased the p62 protein expression and increased GFP-LC3B.	Quercetin	0-9	nucleoporin 62	Homo sapiens	51-54
25997470-5	2015	Quercetin treatment dose-dependently decreased the p62 protein expression and increased GFP-LC3B.	Quercetin	0-9	microtubule associated protein 1 light chain 3 beta	Homo sapiens	92-96
25997470-6	2015	Autophagy flux inhibitor, chloroquine treatment blocked the enhancing effects of TRAIL-induced apoptosis by quercetin.	Quercetin	108-117	TNF superfamily member 10	Homo sapiens	81-86
25997470-7	2015	Our results indicated that quercetin enhanced TRAIL-induced cell death via autophagy flux activation, and also suggest that quercetin may be a therapeutic agent against human lung cancer via combination therapy with many anticancer drugs including TRAIL.	Quercetin	27-36	TNF superfamily member 10	Homo sapiens	46-51
25997470-7	2015	Our results indicated that quercetin enhanced TRAIL-induced cell death via autophagy flux activation, and also suggest that quercetin may be a therapeutic agent against human lung cancer via combination therapy with many anticancer drugs including TRAIL.	Quercetin	27-36	TNF superfamily member 10	Homo sapiens	248-253
25997470-7	2015	Our results indicated that quercetin enhanced TRAIL-induced cell death via autophagy flux activation, and also suggest that quercetin may be a therapeutic agent against human lung cancer via combination therapy with many anticancer drugs including TRAIL.	Quercetin	124-133	TNF superfamily member 10	Homo sapiens	46-51
25997470-7	2015	Our results indicated that quercetin enhanced TRAIL-induced cell death via autophagy flux activation, and also suggest that quercetin may be a therapeutic agent against human lung cancer via combination therapy with many anticancer drugs including TRAIL.	Quercetin	124-133	TNF superfamily member 10	Homo sapiens	248-253
26062553-9	2015	Expression of miR-217 was upregulated after quercetin and/or cisplatin treatment, while its target KRAS was downregulated both at mRNA and protein levels.	Quercetin	44-53	microRNA 217	Homo sapiens	14-21
26062553-10	2015	MiR-217 knockdown led to the loss of enhanced cisplatin sensitivity while miR-217 overexpression showed the opposite effects, indicating that quercetin regulated cisplatin sensitivity by modulating the miR-217-KRAS axis.	Quercetin	142-151	microRNA 217	Homo sapiens	0-7
26062553-10	2015	MiR-217 knockdown led to the loss of enhanced cisplatin sensitivity while miR-217 overexpression showed the opposite effects, indicating that quercetin regulated cisplatin sensitivity by modulating the miR-217-KRAS axis.	Quercetin	142-151	microRNA 217	Homo sapiens	74-81
26062553-10	2015	MiR-217 knockdown led to the loss of enhanced cisplatin sensitivity while miR-217 overexpression showed the opposite effects, indicating that quercetin regulated cisplatin sensitivity by modulating the miR-217-KRAS axis.	Quercetin	142-151	microRNA 217	Homo sapiens	202-209
26062553-10	2015	MiR-217 knockdown led to the loss of enhanced cisplatin sensitivity while miR-217 overexpression showed the opposite effects, indicating that quercetin regulated cisplatin sensitivity by modulating the miR-217-KRAS axis.	Quercetin	142-151	KRAS proto-oncogene, GTPase	Homo sapiens	210-214
26062553-11	2015	In conclusion, 5 muM quercetin enhanced the cisplatin sensitivity by modulating the miR-217-KRAS axis.	Quercetin	21-30	microRNA 217	Homo sapiens	84-91
26062553-11	2015	In conclusion, 5 muM quercetin enhanced the cisplatin sensitivity by modulating the miR-217-KRAS axis.	Quercetin	21-30	KRAS proto-oncogene, GTPase	Homo sapiens	92-96
26061016-0	2015	Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells.	Quercetin	0-9	claudin 2	Homo sapiens	20-29
29124159-6	2015	Particularly, phloretin and quercetin, which are major components of apple juice, were potent in inhibiting OCT1-mediated atenolol transport with the inhibition constants of 38.0 and 48.0 microM, respectively.	Quercetin	28-37	solute carrier family 22 member 1	Homo sapiens	108-112
26111180-8	2015	Combined treatment with curcumin and quercetin resulted in significant inhibition of cell proliferation, accompanied by loss of mitochondrial membrane potential (DeltaPsim), release of cytochrome c and decreased phosphorylation of AKT and ERK.	Quercetin	37-46	cytochrome c, somatic	Homo sapiens	185-197
26111180-8	2015	Combined treatment with curcumin and quercetin resulted in significant inhibition of cell proliferation, accompanied by loss of mitochondrial membrane potential (DeltaPsim), release of cytochrome c and decreased phosphorylation of AKT and ERK.	Quercetin	37-46	AKT serine/threonine kinase 1	Homo sapiens	231-234
26111180-8	2015	Combined treatment with curcumin and quercetin resulted in significant inhibition of cell proliferation, accompanied by loss of mitochondrial membrane potential (DeltaPsim), release of cytochrome c and decreased phosphorylation of AKT and ERK.	Quercetin	37-46	mitogen-activated protein kinase 1	Homo sapiens	239-242
26061016-0	2015	Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells.	Quercetin	0-9	glycerophosphodiester phosphodiesterase 1	Homo sapiens	79-85
26061016-5	2015	We here found that quercetin, a flavonoid present in fruits and vegetables, time- and concentration-dependently decreases claudin-2 expression in lung adenocarcinoma A549 cells.	Quercetin	19-28	claudin 2	Homo sapiens	122-131
26053266-6	2015	Moreover, the activation of the extracellular signal-regulated protein kinases (ERK) and p38 pathways was observed in quercetin-treated rBMSCs.	Quercetin	118-127	Eph receptor B1	Rattus norvegicus	32-78
26053266-6	2015	Moreover, the activation of the extracellular signal-regulated protein kinases (ERK) and p38 pathways was observed in quercetin-treated rBMSCs.	Quercetin	118-127	Eph receptor B1	Rattus norvegicus	80-83
26061016-6	2015	In the present study, we examined what regulatory mechanism is involved in the decrease in claudin-2 expression by quercetin.	Quercetin	115-124	claudin 2	Homo sapiens	91-100
26053266-6	2015	Moreover, the activation of the extracellular signal-regulated protein kinases (ERK) and p38 pathways was observed in quercetin-treated rBMSCs.	Quercetin	118-127	mitogen activated protein kinase 14	Rattus norvegicus	89-92
26061016-11	2015	The stability of claudin-2 mRNA was decreased by quercetin.	Quercetin	49-58	claudin 2	Homo sapiens	17-26
26053266-8	2015	These data indicated that quercetin could promote the proliferation, osteogenic differentiation and angiogenic factor secretion of rBMSCs in vitro, partially through the ERK and p38 signaling pathways.	Quercetin	26-35	Eph receptor B1	Rattus norvegicus	170-173
26053266-8	2015	These data indicated that quercetin could promote the proliferation, osteogenic differentiation and angiogenic factor secretion of rBMSCs in vitro, partially through the ERK and p38 signaling pathways.	Quercetin	26-35	mitogen activated protein kinase 14	Rattus norvegicus	178-181
26061016-12	2015	Quercetin increased the expression of microRNA miR-16.	Quercetin	0-9	glycerophosphodiester phosphodiesterase 1	Homo sapiens	47-53
26061016-13	2015	An inhibitor of miR-16 rescued quercetin-induced decrease in the claudin-2 expression.	Quercetin	31-40	glycerophosphodiester phosphodiesterase 1	Homo sapiens	16-22
26061016-13	2015	An inhibitor of miR-16 rescued quercetin-induced decrease in the claudin-2 expression.	Quercetin	31-40	claudin 2	Homo sapiens	65-74
26061016-14	2015	These results suggest that quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 expression and instability of claudin-2 mRNA in lung adenocarcinoma cells.	Quercetin	27-36	claudin 2	Homo sapiens	47-56
26061016-14	2015	These results suggest that quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 expression and instability of claudin-2 mRNA in lung adenocarcinoma cells.	Quercetin	27-36	glycerophosphodiester phosphodiesterase 1	Homo sapiens	97-103
26061016-14	2015	These results suggest that quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 expression and instability of claudin-2 mRNA in lung adenocarcinoma cells.	Quercetin	27-36	claudin 2	Homo sapiens	134-143
25424246-5	2015	When using HL60, losartan and the CYP3A4-selective inhibitors, erythromycin and ketoconazole, caused a greater inhibition of the paclitaxel metabolism than quercetin, a CYP2C8-selective inhibitor.	Quercetin	156-165	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	34-40
25810437-0	2015	Quercetin attenuates cyclooxygenase-2 expression in response to acute ureteral obstruction.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	21-37
25810437-3	2015	The aim of the present study was to evaluate the effect of quercetin, a naturally occurring antioxidant, on COX-2 induction in vivo and in vitro.	Quercetin	59-68	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	108-113
25810437-5	2015	Quercetin partly prevented COX-2 induction in the renal inner medulla in response to UUO.	Quercetin	0-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	27-32
25810437-7	2015	Interestingly, quercetin reduced COX-2 induction in RMICs subjected to stretched.	Quercetin	15-24	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	33-38
25810437-9	2015	Furthermore, stretch-induced phosphorylation of ERK1/2 was blocked by quercetin, and inhibition of ERK1/2 attenuated stretch-induced COX-2 induction in RMICs.	Quercetin	70-79	mitogen activated protein kinase 3	Rattus norvegicus	48-54
25810437-10	2015	These results indicate that quercetin attenuated the induction of COX-2 expression and activity in RMICs exposed to mechanical stress as a consequence of acute UUO and that the MAPK ERK1/2 pathway might be involved in this quercetin-mediated reduction in COX-2.	Quercetin	28-37	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	66-71
25810437-10	2015	These results indicate that quercetin attenuated the induction of COX-2 expression and activity in RMICs exposed to mechanical stress as a consequence of acute UUO and that the MAPK ERK1/2 pathway might be involved in this quercetin-mediated reduction in COX-2.	Quercetin	28-37	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	255-260
25810437-10	2015	These results indicate that quercetin attenuated the induction of COX-2 expression and activity in RMICs exposed to mechanical stress as a consequence of acute UUO and that the MAPK ERK1/2 pathway might be involved in this quercetin-mediated reduction in COX-2.	Quercetin	223-232	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	66-71
25810437-10	2015	These results indicate that quercetin attenuated the induction of COX-2 expression and activity in RMICs exposed to mechanical stress as a consequence of acute UUO and that the MAPK ERK1/2 pathway might be involved in this quercetin-mediated reduction in COX-2.	Quercetin	223-232	mitogen activated protein kinase 3	Rattus norvegicus	177-181
25810437-10	2015	These results indicate that quercetin attenuated the induction of COX-2 expression and activity in RMICs exposed to mechanical stress as a consequence of acute UUO and that the MAPK ERK1/2 pathway might be involved in this quercetin-mediated reduction in COX-2.	Quercetin	223-232	mitogen activated protein kinase 3	Rattus norvegicus	182-188
25810437-10	2015	These results indicate that quercetin attenuated the induction of COX-2 expression and activity in RMICs exposed to mechanical stress as a consequence of acute UUO and that the MAPK ERK1/2 pathway might be involved in this quercetin-mediated reduction in COX-2.	Quercetin	223-232	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	255-260
24998094-4	2015	Oral administration of the flavonol, quercetin, appears to be an effective and safe method to activate the PGC-1alpha pathway.	Quercetin	37-46	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	107-117
24998094-6	2015	We hypothesized that a quercetin enriched diet would rescue dystrophic muscle from further decline and increase utrophin abundance.	Quercetin	23-32	utrophin	Mus musculus	112-120
25940566-5	2015	We also determined that quercetin and mangiferin selectively activated ERalpha whereas norathyriol activated both ERalpha and ERbeta.	Quercetin	24-33	estrogen receptor 1	Homo sapiens	71-78
24659525-4	2015	The reduction activity was also inhibited by quercetin and menadione [carbonyl reductase (CBR) inhibitors], and by phenolphthalein and medroxyprogesterone acetate [potent inhibitors of aldo-keto reductase (AKR) 1C1, 1C2 and 1C4] in the cytosol.	Quercetin	45-54	carbonyl reductase 1	Homo sapiens	70-88
24659525-4	2015	The reduction activity was also inhibited by quercetin and menadione [carbonyl reductase (CBR) inhibitors], and by phenolphthalein and medroxyprogesterone acetate [potent inhibitors of aldo-keto reductase (AKR) 1C1, 1C2 and 1C4] in the cytosol.	Quercetin	45-54	carbonyl reductase 1	Homo sapiens	90-93
26136938-1	2015	The aim of the present study was to investigate the effects of quercetin on the mitogen-activated protein kinase (MAPK) signaling pathway in the osteogenic differentiation of rat mesenchymal stem cells (MSCs).	Quercetin	63-72	mitogen activated protein kinase 3	Rattus norvegicus	114-118
26136938-8	2015	Furthermore, the mRNA expression levels of TGF-beta1, BMP-2 and CBFalpha1 decreased in the quercetin + SP600125 (inhibitor of JNK) and quercetin + PD98059 (inhibitor of ERK1/2) groups.	Quercetin	91-100	transforming growth factor, beta 1	Rattus norvegicus	43-52
26136938-8	2015	Furthermore, the mRNA expression levels of TGF-beta1, BMP-2 and CBFalpha1 decreased in the quercetin + SP600125 (inhibitor of JNK) and quercetin + PD98059 (inhibitor of ERK1/2) groups.	Quercetin	91-100	bone morphogenetic protein 2	Rattus norvegicus	54-59
26136938-8	2015	Furthermore, the mRNA expression levels of TGF-beta1, BMP-2 and CBFalpha1 decreased in the quercetin + SP600125 (inhibitor of JNK) and quercetin + PD98059 (inhibitor of ERK1/2) groups.	Quercetin	91-100	RUNX family transcription factor 2	Rattus norvegicus	64-73
26136938-8	2015	Furthermore, the mRNA expression levels of TGF-beta1, BMP-2 and CBFalpha1 decreased in the quercetin + SP600125 (inhibitor of JNK) and quercetin + PD98059 (inhibitor of ERK1/2) groups.	Quercetin	91-100	mitogen-activated protein kinase 8	Rattus norvegicus	126-129
26136938-8	2015	Furthermore, the mRNA expression levels of TGF-beta1, BMP-2 and CBFalpha1 decreased in the quercetin + SP600125 (inhibitor of JNK) and quercetin + PD98059 (inhibitor of ERK1/2) groups.	Quercetin	135-144	transforming growth factor, beta 1	Rattus norvegicus	43-52
26136938-8	2015	Furthermore, the mRNA expression levels of TGF-beta1, BMP-2 and CBFalpha1 decreased in the quercetin + SP600125 (inhibitor of JNK) and quercetin + PD98059 (inhibitor of ERK1/2) groups.	Quercetin	135-144	bone morphogenetic protein 2	Rattus norvegicus	54-59
26136938-8	2015	Furthermore, the mRNA expression levels of TGF-beta1, BMP-2 and CBFalpha1 decreased in the quercetin + SP600125 (inhibitor of JNK) and quercetin + PD98059 (inhibitor of ERK1/2) groups.	Quercetin	135-144	RUNX family transcription factor 2	Rattus norvegicus	64-73
26136938-8	2015	Furthermore, the mRNA expression levels of TGF-beta1, BMP-2 and CBFalpha1 decreased in the quercetin + SP600125 (inhibitor of JNK) and quercetin + PD98059 (inhibitor of ERK1/2) groups.	Quercetin	135-144	mitogen activated protein kinase 3	Rattus norvegicus	169-175
26136938-9	2015	Therefore, quercetin was demonstrated to promote the osteogenic differentiation of MSCs by activating the MAPK signaling pathway.	Quercetin	11-20	mitogen activated protein kinase 3	Rattus norvegicus	106-110
26136938-11	2015	Thus, activation of the ERK1/2 and JNK signaling pathways may play a leading role in the quercetin-promoted osteogenic proliferation and differentiation of MSCs.	Quercetin	89-98	mitogen activated protein kinase 3	Rattus norvegicus	24-30
26136938-11	2015	Thus, activation of the ERK1/2 and JNK signaling pathways may play a leading role in the quercetin-promoted osteogenic proliferation and differentiation of MSCs.	Quercetin	89-98	mitogen-activated protein kinase 8	Rattus norvegicus	35-38
25739980-0	2015	Modulation of HMGB1 translocation and RAGE/NFkappaB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice.	Quercetin	63-72	high mobility group box 1	Mus musculus	14-19
25739980-0	2015	Modulation of HMGB1 translocation and RAGE/NFkappaB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice.	Quercetin	63-72	advanced glycosylation end product-specific receptor	Mus musculus	38-42
25739980-0	2015	Modulation of HMGB1 translocation and RAGE/NFkappaB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice.	Quercetin	63-72	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-51
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	high mobility group box 1	Mus musculus	59-64
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	advanced glycosylation end product-specific receptor	Mus musculus	66-70
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-90
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	cytochrome c oxidase II, mitochondrial	Mus musculus	102-106
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	tumor necrosis factor	Mus musculus	108-116
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	interleukin 1 beta	Mus musculus	118-126
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	interleukin 2 receptor, alpha chain	Mus musculus	128-138
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	interferon gamma	Mus musculus	140-148
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	interleukin 4	Mus musculus	153-157
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	182-186
25739980-10	2015	Our data demonstrated that the HMGB1/RAGE/NFkappaB signalling might play an important role in skin inflammation, and quercetin treatment could be a promising agent for AD by modulating the HMGB1/RAGE/NFkappaB signalling and induction of Nrf2 protein.	Quercetin	117-126	high mobility group box 1	Mus musculus	189-194
25739980-10	2015	Our data demonstrated that the HMGB1/RAGE/NFkappaB signalling might play an important role in skin inflammation, and quercetin treatment could be a promising agent for AD by modulating the HMGB1/RAGE/NFkappaB signalling and induction of Nrf2 protein.	Quercetin	117-126	advanced glycosylation end product-specific receptor	Mus musculus	195-199
25739980-10	2015	Our data demonstrated that the HMGB1/RAGE/NFkappaB signalling might play an important role in skin inflammation, and quercetin treatment could be a promising agent for AD by modulating the HMGB1/RAGE/NFkappaB signalling and induction of Nrf2 protein.	Quercetin	117-126	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	200-208
25739980-10	2015	Our data demonstrated that the HMGB1/RAGE/NFkappaB signalling might play an important role in skin inflammation, and quercetin treatment could be a promising agent for AD by modulating the HMGB1/RAGE/NFkappaB signalling and induction of Nrf2 protein.	Quercetin	117-126	nuclear factor, erythroid derived 2, like 2	Mus musculus	237-241
25788151-9	2015	Additionally, quercetin showed inhibition of transcriptional activation and mRNA-expression of HNF4alpha and its target genes.	Quercetin	14-23	hepatocyte nuclear factor 4 alpha	Homo sapiens	95-104
25891365-7	2015	Quercetin significantly decreased the expression of transcription factors, including C/EBPalpha, PPARgamma and SREBP-1c both at the protein and mRNA level.	Quercetin	0-9	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	85-95
25891365-7	2015	Quercetin significantly decreased the expression of transcription factors, including C/EBPalpha, PPARgamma and SREBP-1c both at the protein and mRNA level.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Mus musculus	97-106
25891365-7	2015	Quercetin significantly decreased the expression of transcription factors, including C/EBPalpha, PPARgamma and SREBP-1c both at the protein and mRNA level.	Quercetin	0-9	sterol regulatory element binding transcription factor 1	Mus musculus	111-119
25891365-8	2015	The results from the present study demonstrate that quercetin prevents adipogenesis by upregulating ATGL and HSL expression and downregulating FAS, LPL and adipocyte fatty acid-binding protein (aP2) expression, as well as the expression of transcription factors.	Quercetin	52-61	patatin-like phospholipase domain containing 2	Mus musculus	100-104
25891365-8	2015	The results from the present study demonstrate that quercetin prevents adipogenesis by upregulating ATGL and HSL expression and downregulating FAS, LPL and adipocyte fatty acid-binding protein (aP2) expression, as well as the expression of transcription factors.	Quercetin	52-61	lipase, hormone sensitive	Mus musculus	109-112
25891365-8	2015	The results from the present study demonstrate that quercetin prevents adipogenesis by upregulating ATGL and HSL expression and downregulating FAS, LPL and adipocyte fatty acid-binding protein (aP2) expression, as well as the expression of transcription factors.	Quercetin	52-61	fatty acid synthase	Mus musculus	143-146
25891365-8	2015	The results from the present study demonstrate that quercetin prevents adipogenesis by upregulating ATGL and HSL expression and downregulating FAS, LPL and adipocyte fatty acid-binding protein (aP2) expression, as well as the expression of transcription factors.	Quercetin	52-61	lipoprotein lipase	Mus musculus	148-151
25891365-8	2015	The results from the present study demonstrate that quercetin prevents adipogenesis by upregulating ATGL and HSL expression and downregulating FAS, LPL and adipocyte fatty acid-binding protein (aP2) expression, as well as the expression of transcription factors.	Quercetin	52-61	fatty acid binding protein 4, adipocyte	Mus musculus	194-197
26261493-0	2015	Synergistic effects of snail and quercetin on renal cell carcinoma Caki-2 by altering AKT/mTOR/ERK1/2 signaling pathways.	Quercetin	33-42	AKT serine/threonine kinase 1	Homo sapiens	86-89
26261493-0	2015	Synergistic effects of snail and quercetin on renal cell carcinoma Caki-2 by altering AKT/mTOR/ERK1/2 signaling pathways.	Quercetin	33-42	mechanistic target of rapamycin kinase	Homo sapiens	90-94
26261493-0	2015	Synergistic effects of snail and quercetin on renal cell carcinoma Caki-2 by altering AKT/mTOR/ERK1/2 signaling pathways.	Quercetin	33-42	mitogen-activated protein kinase 3	Homo sapiens	95-101
26261493-3	2015	Therefore, in current study, we explore the anti-tumoral effect of a potential chemopreventive natural product, quercetin, combined with anti-sense oligo gene therapy (inhibiting Snail gene).	Quercetin	112-121	snail family transcriptional repressor 1	Homo sapiens	179-184
26164506-1	2015	OBJECTIVE: To study the effect of quercetin, an inhibitor of matrix metalloproteinases 9 (MMP-9), on the growth and metastasis of lung cancer cells and the underlying mechanisms.	Quercetin	34-43	matrix metallopeptidase 9	Homo sapiens	61-88
25947292-0	2015	PLGA-Loaded Gold-Nanoparticles Precipitated with Quercetin Downregulate HDAC-Akt Activities Controlling Proliferation and Activate p53-ROS Crosstalk to Induce Apoptosis in Hepatocarcinoma Cells.	Quercetin	49-58	tumor protein p53	Homo sapiens	131-134
25625855-0	2015	Quercetin attenuates the effects of H2O2 on endoplasmic reticulum morphology and tyrosinase export from the endoplasmic reticulum in melanocytes.	Quercetin	0-9	tyrosinase	Homo sapiens	81-91
25625855-3	2015	The aim of the present study was to further investigate the role of H2O2 in the ER of melanocytes as well as its role in the export of tyrosinase from ER; in addition, the present study aimed to determine the mechanism by which quercetin protects against the effects of H2O2.	Quercetin	228-237	tyrosinase	Homo sapiens	135-145
26164506-1	2015	OBJECTIVE: To study the effect of quercetin, an inhibitor of matrix metalloproteinases 9 (MMP-9), on the growth and metastasis of lung cancer cells and the underlying mechanisms.	Quercetin	34-43	matrix metallopeptidase 9	Homo sapiens	90-95
26164506-2	2015	:  METHODS: We evaluated the inhibitory effect and the inhibitory kinetics of quercetin on MMP-9 by ELISA and enzyme inhibition kinetics, and the inhibitory effect of quercetin on the growth of lung cancer cell (A549) by MTT.	Quercetin	78-87	matrix metallopeptidase 9	Homo sapiens	91-96
26164506-3	2015	The effect of quercetin on levels of MMP-9 (mRNA and protein) and TGF-beta1 (protein) in A549 were measured by RT-PCR and Western blot, respectively.	Quercetin	14-23	matrix metallopeptidase 9	Homo sapiens	37-42
26164506-3	2015	The effect of quercetin on levels of MMP-9 (mRNA and protein) and TGF-beta1 (protein) in A549 were measured by RT-PCR and Western blot, respectively.	Quercetin	14-23	transforming growth factor beta 1	Homo sapiens	66-75
26164506-7	2015	With the increase in quercetin concentration, the levels of MMP-9 (mRNA and protein) and TGF-beta1 (protein) were decreased, and the number of tumor cells on wear filter membrane was reduced.	Quercetin	21-30	matrix metallopeptidase 9	Homo sapiens	60-65
26164506-7	2015	With the increase in quercetin concentration, the levels of MMP-9 (mRNA and protein) and TGF-beta1 (protein) were decreased, and the number of tumor cells on wear filter membrane was reduced.	Quercetin	21-30	transforming growth factor beta 1	Homo sapiens	89-98
26164506-9	2015	:  CONCLUSION: Quercetin is a competitive inhibitor of MMP-9 and could downregulate the expression of MMP-9 and TGF-beta1, which plays an important role in A549 apoptosis.	Quercetin	15-24	matrix metallopeptidase 9	Homo sapiens	55-60
26164506-9	2015	:  CONCLUSION: Quercetin is a competitive inhibitor of MMP-9 and could downregulate the expression of MMP-9 and TGF-beta1, which plays an important role in A549 apoptosis.	Quercetin	15-24	matrix metallopeptidase 9	Homo sapiens	102-107
26164506-9	2015	:  CONCLUSION: Quercetin is a competitive inhibitor of MMP-9 and could downregulate the expression of MMP-9 and TGF-beta1, which plays an important role in A549 apoptosis.	Quercetin	15-24	transforming growth factor beta 1	Homo sapiens	112-121
25971889-0	2015	Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion.	Quercetin	0-9	hepatocyte growth factor	Homo sapiens	19-22
26221305-6	2015	The changes of ICP and MBp were determined by cavernous nerve electrostimulation after treatment of quercetin at indicated doses.	Quercetin	100-109	myelin basic protein	Rattus norvegicus	23-26
26221305-9	2015	The data also showed that sGC inhibitor ODQ and NOS inhibitor LNNA can significantly inhibited the ICP which induced by quercetin.	Quercetin	120-129	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	26-29
26221305-13	2015	iNOS expression have a certain degree of increased after quercetin treatment.	Quercetin	57-66	nitric oxide synthase 2	Rattus norvegicus	0-4
26059439-8	2015	Although both quercetin and isoliquiritigenin are cytotoxic to SNU719 cells, quercetin induced more apoptosis in SNU719 cells than isoliquiritigenin, more completely eliminated DNMT1 and DNMT3A expressions than isoliquiritigenin, and more strongly affects the cell cycle progression of SNU719 than isoliquiritigenin.	Quercetin	77-86	DNA methyltransferase 1	Homo sapiens	177-182
26059439-8	2015	Although both quercetin and isoliquiritigenin are cytotoxic to SNU719 cells, quercetin induced more apoptosis in SNU719 cells than isoliquiritigenin, more completely eliminated DNMT1 and DNMT3A expressions than isoliquiritigenin, and more strongly affects the cell cycle progression of SNU719 than isoliquiritigenin.	Quercetin	77-86	DNA methyltransferase 3 alpha	Homo sapiens	187-193
25971889-0	2015	Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion.	Quercetin	0-9	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	23-28
25971889-0	2015	Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion.	Quercetin	0-9	hepatocyte growth factor	Homo sapiens	43-46
25971889-6	2015	In this study, we sought to determine the involvement of HGF/c-Met signaling in the anti-metastatic action of quercetin in melanoma.	Quercetin	110-119	hepatocyte growth factor	Homo sapiens	57-60
25971889-6	2015	In this study, we sought to determine the involvement of HGF/c-Met signaling in the anti-metastatic action of quercetin in melanoma.	Quercetin	110-119	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	61-66
25971889-13	2015	RESULTS: Quercetin dose-dependently suppressed HGF-stimulated melanoma cell migration and invasion.	Quercetin	9-18	hepatocyte growth factor	Homo sapiens	47-50
25971889-14	2015	Further study indicated that quercetin inhibited c-Met phosphorylation, reduced c-Met homo-dimerization and decreased c-Met protein expression.	Quercetin	29-38	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	49-54
25985359-2	2015	Based on considerable structural information obtained through ESI-MSn, all of the first transition metal ions (Fe2+, Co2+, Ni2+, Cu2+ and Zn2+) were found to form different complexes with quercetin, while with the number of chelating flavonoids decreasing along with the reduction of the metal ionic radius.	Quercetin	188-197	moesin	Homo sapiens	66-69
25971889-14	2015	Further study indicated that quercetin inhibited c-Met phosphorylation, reduced c-Met homo-dimerization and decreased c-Met protein expression.	Quercetin	29-38	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	80-85
25971889-14	2015	Further study indicated that quercetin inhibited c-Met phosphorylation, reduced c-Met homo-dimerization and decreased c-Met protein expression.	Quercetin	29-38	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	80-85
25971889-15	2015	The effect of quercetin on c-Met expression was associated with a reduced expression of fatty acid synthase.	Quercetin	14-23	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	27-32
25971889-15	2015	The effect of quercetin on c-Met expression was associated with a reduced expression of fatty acid synthase.	Quercetin	14-23	fatty acid synthase	Homo sapiens	88-107
25971889-16	2015	In addition, quercetin suppressed the phosphorylation of c-Met downstream molecules including Gab1 (GRB2-associated-binding protein 1), FAK (Focal Adhesion Kinase) and PAK (p21-activated kinases).	Quercetin	13-22	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	57-62
25971889-16	2015	In addition, quercetin suppressed the phosphorylation of c-Met downstream molecules including Gab1 (GRB2-associated-binding protein 1), FAK (Focal Adhesion Kinase) and PAK (p21-activated kinases).	Quercetin	13-22	GRB2 associated binding protein 1	Homo sapiens	94-98
25971889-16	2015	In addition, quercetin suppressed the phosphorylation of c-Met downstream molecules including Gab1 (GRB2-associated-binding protein 1), FAK (Focal Adhesion Kinase) and PAK (p21-activated kinases).	Quercetin	13-22	GRB2 associated binding protein 1	Homo sapiens	100-133
25971889-16	2015	In addition, quercetin suppressed the phosphorylation of c-Met downstream molecules including Gab1 (GRB2-associated-binding protein 1), FAK (Focal Adhesion Kinase) and PAK (p21-activated kinases).	Quercetin	13-22	protein tyrosine kinase 2	Homo sapiens	136-139
25971889-16	2015	In addition, quercetin suppressed the phosphorylation of c-Met downstream molecules including Gab1 (GRB2-associated-binding protein 1), FAK (Focal Adhesion Kinase) and PAK (p21-activated kinases).	Quercetin	13-22	protein tyrosine kinase 2	Homo sapiens	141-162
25971889-17	2015	More importantly, overexpression of FAK or PAK significantly reduced the inhibitory effect of quercetin on the migration of the melanoma cells.	Quercetin	94-103	protein tyrosine kinase 2	Homo sapiens	36-39
25971889-18	2015	CONCLUSIONS: Our findings suggest that suppression of the HGF/c-Met signaling pathway contributes to the anti-metastatic action of quercetin in melanoma.	Quercetin	131-140	hepatocyte growth factor	Homo sapiens	58-61
25971889-18	2015	CONCLUSIONS: Our findings suggest that suppression of the HGF/c-Met signaling pathway contributes to the anti-metastatic action of quercetin in melanoma.	Quercetin	131-140	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	62-67
26214621-9	2015	Further, with increasing dosage of quercetin, we observed a gradual reduction in Her-2 expression and upregulation of ERalpha.	Quercetin	35-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	81-86
25793633-3	2015	In addition, we found that quercetin significantly decreased the phosphorylation of ERK1/2 and FAK, a downstream ERK signaling protein.	Quercetin	27-36	mitogen-activated protein kinase 3	Homo sapiens	84-90
25793633-3	2015	In addition, we found that quercetin significantly decreased the phosphorylation of ERK1/2 and FAK, a downstream ERK signaling protein.	Quercetin	27-36	protein tyrosine kinase 2	Homo sapiens	95-98
25793633-3	2015	In addition, we found that quercetin significantly decreased the phosphorylation of ERK1/2 and FAK, a downstream ERK signaling protein.	Quercetin	27-36	mitogen-activated protein kinase 1	Homo sapiens	84-87
25793633-5	2015	Our findings thus indicate that quercetin inhibits healing in the scratch-wound model of primary astrocytes in two ways: blockade of the G1 to S phase cell cycle transition and inhibition of the ERK/FAK signaling pathway, which may contribute toward decreasing astroglial scar formation in vivo.	Quercetin	32-41	mitogen-activated protein kinase 1	Homo sapiens	195-198
25793633-5	2015	Our findings thus indicate that quercetin inhibits healing in the scratch-wound model of primary astrocytes in two ways: blockade of the G1 to S phase cell cycle transition and inhibition of the ERK/FAK signaling pathway, which may contribute toward decreasing astroglial scar formation in vivo.	Quercetin	32-41	protein tyrosine kinase 2	Homo sapiens	199-202
25995828-9	2015	In particular, quercetin exhibited similar inhibitory activities against tyrosinase and L-DOPA oxidation without cytotoxicity.	Quercetin	15-24	tyrosinase	Mus musculus	73-83
25983116-0	2015	Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells.	Quercetin	0-9	advanced glycosylation end-product specific receptor	Homo sapiens	91-95
25983116-0	2015	Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells.	Quercetin	0-9	high mobility group box 1	Homo sapiens	111-116
25983116-6	2015	This study was aimed to examine the biological potential of quercetin on the regulation of RAGE- and HMGB1-mediated activation of NF-kappaB and induction of apoptotic cell death in MCF-7 cells.	Quercetin	60-69	advanced glycosylation end-product specific receptor	Homo sapiens	91-95
25983116-6	2015	This study was aimed to examine the biological potential of quercetin on the regulation of RAGE- and HMGB1-mediated activation of NF-kappaB and induction of apoptotic cell death in MCF-7 cells.	Quercetin	60-69	high mobility group box 1	Homo sapiens	101-106
25983116-7	2015	Our findings demonstrate that quercetin inhibits the expression of RAGE and HMGB1 in MCF-7 cells.	Quercetin	30-39	advanced glycosylation end-product specific receptor	Homo sapiens	67-71
25983116-7	2015	Our findings demonstrate that quercetin inhibits the expression of RAGE and HMGB1 in MCF-7 cells.	Quercetin	30-39	high mobility group box 1	Homo sapiens	76-81
25983116-9	2015	Taken together, these results suggest that quercetin plays an important role in modulating RAGE and HMGB1 signaling and induces apoptotic cell death in MCF-7 cells.	Quercetin	43-52	advanced glycosylation end-product specific receptor	Homo sapiens	91-95
25983116-9	2015	Taken together, these results suggest that quercetin plays an important role in modulating RAGE and HMGB1 signaling and induces apoptotic cell death in MCF-7 cells.	Quercetin	43-52	high mobility group box 1	Homo sapiens	100-105
26214621-9	2015	Further, with increasing dosage of quercetin, we observed a gradual reduction in Her-2 expression and upregulation of ERalpha.	Quercetin	35-44	estrogen receptor 1	Homo sapiens	118-125
25896339-0	2015	Nrf2 Expression and Apoptosis in Quercetin-treated Malignant Mesothelioma Cells.	Quercetin	33-42	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
25867625-12	2015	Moreover, the increased accumulation of the flavonols quercetin and kaempferol appears closely related to the increase of PAL5, chalcone synthase (CHS) and flavonol synthase/flavanone 3-hydroxylase-like (FLS) genes.	Quercetin	54-63	phenylalanine ammonia-lyase	Solanum lycopersicum	122-126
25867625-12	2015	Moreover, the increased accumulation of the flavonols quercetin and kaempferol appears closely related to the increase of PAL5, chalcone synthase (CHS) and flavonol synthase/flavanone 3-hydroxylase-like (FLS) genes.	Quercetin	54-63	chalcone synthase 1	Solanum lycopersicum	128-145
25867625-12	2015	Moreover, the increased accumulation of the flavonols quercetin and kaempferol appears closely related to the increase of PAL5, chalcone synthase (CHS) and flavonol synthase/flavanone 3-hydroxylase-like (FLS) genes.	Quercetin	54-63	LOC101250319	Solanum lycopersicum	156-202
25867625-12	2015	Moreover, the increased accumulation of the flavonols quercetin and kaempferol appears closely related to the increase of PAL5, chalcone synthase (CHS) and flavonol synthase/flavanone 3-hydroxylase-like (FLS) genes.	Quercetin	54-63	LOC101250319	Solanum lycopersicum	204-207
25712622-0	2015	Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	75-78
25712622-6	2015	Treatment with quercetin reduced AKT phosphorylation, and oxidative/nitrosative stress, inflammation and lipid metabolism-related genes displayed a tendency to normalize in both in vivo and in vitro models.	Quercetin	15-24	thymoma viral proto-oncogene 1	Mus musculus	33-36
25712622-7	2015	CONCLUSION: These results place quercetin as a potential therapeutic strategy for preventing NAFLD progression by attenuating gene expression deregulation, at least in part through PI3K/AKT pathway inactivation.	Quercetin	32-41	thymoma viral proto-oncogene 1	Mus musculus	186-189
25896339-2	2015	In this study, we investigated the apoptosis-inducing and Nrf2-upregulating effects of quercetin on malignant mesothelioma (MM) MSTO-211H and H2452 cells.	Quercetin	87-96	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
25896339-3	2015	Quercetin treatment inhibited cell growth and led to upregulation of Nrf2 at both the mRNA and protein levels without altering the ubiquitination and extending the half-life of the Nrf2 protein.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
25896339-4	2015	Following treatment with quercetin, analyses of the nuclear level of Nrf2, Nrf2 antioxidant response element-binding assay, Nrf2 promoter-luc assay, and RT-PCR toward the Nrf2-regulated gene, heme oxygenase-1, demonstrated that the induced Nrf2 is transcriptionally active.	Quercetin	25-34	heme oxygenase 1	Homo sapiens	192-208
24601972-4	2015	Docetaxel caused a significant increase in TBARS level and a significant decrease in SOD, GPX, CAT and GSH levels in the testicular tissues compared with the control group, whereas quercetin led to a significant decrease in lipid peroxidation, which was caused by docetaxel, via reducing TBARS level and increasing the levels of SOD, CAT, GPX and GSH.	Quercetin	181-190	catalase	Rattus norvegicus	334-337
25684704-6	2015	The flavonoids, quercetin, and kaempferol showed potent (IC50 values less than 100 muM) inhibition of CYP3A4 activity, whereas quercetin alone showed potent inhibition of CYP2D6 activity in HLM.	Quercetin	16-25	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	102-108
25684704-6	2015	The flavonoids, quercetin, and kaempferol showed potent (IC50 values less than 100 muM) inhibition of CYP3A4 activity, whereas quercetin alone showed potent inhibition of CYP2D6 activity in HLM.	Quercetin	16-25	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	171-177
25684704-6	2015	The flavonoids, quercetin, and kaempferol showed potent (IC50 values less than 100 muM) inhibition of CYP3A4 activity, whereas quercetin alone showed potent inhibition of CYP2D6 activity in HLM.	Quercetin	127-136	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	171-177
25995762-8	2015	Moreover, quercetin significantly (p &lt; 0.05) attenuated the increase in the BALF protein level and neutrophil count and lung wet/dry weight ratio and myeloperoxidase activity in LPS-challenged rats.	Quercetin	10-19	myeloperoxidase	Rattus norvegicus	153-168
25995762-9	2015	The LPS exposure evoked a 4- to 5-fold rise in BALF levels of tumor necrosis factor-alpha and interleukin-6, which was significantly (p &lt; 0.05) counteracted by quercetin pretreatment.	Quercetin	163-172	tumor necrosis factor	Rattus norvegicus	62-89
25995762-9	2015	The LPS exposure evoked a 4- to 5-fold rise in BALF levels of tumor necrosis factor-alpha and interleukin-6, which was significantly (p &lt; 0.05) counteracted by quercetin pretreatment.	Quercetin	163-172	interleukin 6	Rattus norvegicus	94-107
25995762-10	2015	Additionally, quercetin significantly (p &lt; 0.05) suppressed the malondialdehyde level and increased the activities of superoxide dismutase, catalase, and glutathione peroxidase in the lung of LPS-treated rats.	Quercetin	14-23	catalase	Rattus norvegicus	143-151
25872140-0	2015	Quercetin improves postischemic recovery of heart function in doxorubicin-treated rats and prevents doxorubicin-induced matrix metalloproteinase-2 activation and apoptosis induction.	Quercetin	0-9	matrix metallopeptidase 2	Rattus norvegicus	120-146
25875015-0	2015	Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPbeta.	Quercetin	0-9	apolipoprotein B	Homo sapiens	20-36
25875015-0	2015	Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPbeta.	Quercetin	0-9	CCAAT enhancer binding protein beta	Homo sapiens	94-103
25875015-4	2015	We found that mRNA levels of some apolipoproteins, particularly apolipoprotein B (apoB), are downregulated in the presence of quercetin.	Quercetin	126-135	apolipoprotein B	Homo sapiens	64-80
25875015-4	2015	We found that mRNA levels of some apolipoproteins, particularly apolipoprotein B (apoB), are downregulated in the presence of quercetin.	Quercetin	126-135	apolipoprotein B	Homo sapiens	82-86
25875015-5	2015	On the exposure of Caco-2 cells to quercetin, both mRNA and protein levels of apoB were decreased.	Quercetin	35-44	apolipoprotein B	Homo sapiens	78-82
25875015-7	2015	We found that quercetin reduces the promoter activity of apoB, driven by the enforced expression of C/EBPbeta.	Quercetin	14-23	apolipoprotein B	Homo sapiens	57-61
25875015-7	2015	We found that quercetin reduces the promoter activity of apoB, driven by the enforced expression of C/EBPbeta.	Quercetin	14-23	CCAAT enhancer binding protein beta	Homo sapiens	100-109
25875015-9	2015	In contrast, we found that quercetin inhibits the transcriptional activity of C/EBPbeta but not its recruitment to the apoB promoter.	Quercetin	27-36	CCAAT enhancer binding protein beta	Homo sapiens	78-87
25875015-11	2015	In vitro interaction experiments using quercetin-conjugated beads revealed that quercetin binds to C/EBPbeta.	Quercetin	39-48	CCAAT enhancer binding protein beta	Homo sapiens	99-108
25875015-11	2015	In vitro interaction experiments using quercetin-conjugated beads revealed that quercetin binds to C/EBPbeta.	Quercetin	80-89	CCAAT enhancer binding protein beta	Homo sapiens	99-108
26081216-11	2015	The retinal level of VEGF decreased significantly in quercetin treatment group.	Quercetin	53-62	vascular endothelial growth factor A	Mus musculus	21-25
25706320-6	2015	Among them, f8, f4 and f6 (IC50=1.64, 1.82 and 2.69 muM, respectively) showed significantly better ABTS cation radical scavenging ability than standard quercetin (IC50 = 15.49 muM).	Quercetin	152-161	latexin	Homo sapiens	52-55
25706320-6	2015	Among them, f8, f4 and f6 (IC50=1.64, 1.82 and 2.69 muM, respectively) showed significantly better ABTS cation radical scavenging ability than standard quercetin (IC50 = 15.49 muM).	Quercetin	152-161	latexin	Homo sapiens	176-179
26066604-10	2015	CONCLUSIONS: Quercetin and RES have anti-inflammatory and antioxidant effects on IOBA-NHC and HCE cells.	Quercetin	13-22	RNA guanylyltransferase and 5'-phosphatase	Homo sapiens	94-97
26066604-5	2015	Quercetin and RES decreased IL-6 and IP-10 secretion in a dose-dependent manner in both cell lines.	Quercetin	0-9	interleukin 6	Homo sapiens	28-32
25596948-0	2015	Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells.	Quercetin	0-9	microRNA 146a	Homo sapiens	68-76
26066604-5	2015	Quercetin and RES decreased IL-6 and IP-10 secretion in a dose-dependent manner in both cell lines.	Quercetin	0-9	C-X-C motif chemokine ligand 10	Homo sapiens	37-42
25596948-6	2015	All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells, which was performed by up-regulating miR-146a expression, then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways, and inhibiting invasion through down-regulating the expression of EGFR.	Quercetin	34-43	caspase 3	Homo sapiens	228-237
25596948-6	2015	All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells, which was performed by up-regulating miR-146a expression, then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways, and inhibiting invasion through down-regulating the expression of EGFR.	Quercetin	34-43	microRNA 146a	Homo sapiens	171-179
25596948-6	2015	All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells, which was performed by up-regulating miR-146a expression, then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways, and inhibiting invasion through down-regulating the expression of EGFR.	Quercetin	34-43	epidermal growth factor receptor	Homo sapiens	353-357
25829782-6	2015	In this study, we demonstrate that quercetin induces apoptosis in human colon cancer CACO-2 and SW-620 cells through inhibiting NF-kappaB pathway, as well as down-regulation of B-cell lymphoma 2 and up-regulation of Bax, thus providing basis for clinical application of quercetin in colon cancer cases.	Quercetin	35-44	nuclear factor kappa B subunit 1	Homo sapiens	128-137
25829782-6	2015	In this study, we demonstrate that quercetin induces apoptosis in human colon cancer CACO-2 and SW-620 cells through inhibiting NF-kappaB pathway, as well as down-regulation of B-cell lymphoma 2 and up-regulation of Bax, thus providing basis for clinical application of quercetin in colon cancer cases.	Quercetin	35-44	BCL2 associated X, apoptosis regulator	Homo sapiens	216-219
25758533-9	2015	Quercetin down regulated TGF-betaR2 and TGF-beta2 expression in HKCs suggesting a significant link to the TGF-beta pathway.	Quercetin	0-9	transforming growth factor beta 2	Homo sapiens	25-28
25561246-8	2015	Quercetin significantly inhibited 6beta- and 11beta-hydroxytestosterone in all species investigated, suggesting that CYP2C8 is involved in testosterone metabolism, whereas sulfaphenazole significantly inhibited the formation of 6beta- and 11beta-hydroxytestosterone in human microsomes, at 60 min in equine microsomes, but not in canine microsomes.	Quercetin	0-9	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	117-123
25758533-9	2015	Quercetin down regulated TGF-betaR2 and TGF-beta2 expression in HKCs suggesting a significant link to the TGF-beta pathway.	Quercetin	0-9	transforming growth factor beta 2	Homo sapiens	40-49
25758533-9	2015	Quercetin down regulated TGF-betaR2 and TGF-beta2 expression in HKCs suggesting a significant link to the TGF-beta pathway.	Quercetin	0-9	transforming growth factor beta 2	Homo sapiens	25-33
25758533-10	2015	These results assert that Quercetin is a key regulator of fibrotic markers and ECM assembly by modulating cellular metabolism and TGF-beta signaling.	Quercetin	26-35	transforming growth factor beta 2	Homo sapiens	130-138
25485477-6	2015	The cytochrome c/H2O2 permeabilization activity was substantially diminished by antioxidants (trolox, butylhydroxytoluene and quercetin) and was precluded if fully saturated tetramyristoyl-cardiolipin was substituted for bovine heart cardiolipin.	Quercetin	126-135	LOC104968582	Bos taurus	4-16
25945531-10	2015	The antiapoptotic effect of quercetin in terms of reducing the numbers of both TUNEL (+) cells and caspase-3 (+) cells was significant in INL.	Quercetin	28-37	caspase 3	Rattus norvegicus	99-108
25945531-12	2015	The mean number of caspase-3 (+) cells in INL of ischemic and quercetin groups was 633.6 +- 38.7/mm2 and 342.4 +- 36.1/mm2, respectively (P&lt;0.001).	Quercetin	62-71	caspase 3	Rattus norvegicus	19-28
25611565-0	2015	Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling.	Quercetin	0-9	signal transducer and activator of transcription 3	Mus musculus	110-115
25319353-4	2015	In this study, SMN2-inducing effects of quercetin, an abundant flavonoid polyphenol in human diet, was investigated in the fibroblast cell lines of two SMA type I patients.	Quercetin	40-49	survival of motor neuron 2, centromeric	Homo sapiens	15-19
25319353-5	2015	Gene expression studies showed that quercetin upregulates SMN2 mRNA up to fourfold, but not the SMN protein level.	Quercetin	36-45	survival of motor neuron 2, centromeric	Homo sapiens	58-62
25776502-0	2015	Quercetin derivatives regulate melanosome transportation via EPI64 inhibition and elongate the cell shape of B16 melanoma cells.	Quercetin	0-9	TBC1 domain family, member 10a	Mus musculus	61-66
25373458-5	2015	HUVEC proliferation induced by HG was observed to be reduced by the HSP27 inhibitor quercetin in a concentration-dependent manner, with a concomitant increase in apoptosis.	Quercetin	84-93	heat shock protein family B (small) member 1	Homo sapiens	68-73
25662315-7	2015	In addition, we probed the signaling behind the effects and observed that p38 and ERK MAPK pathways, and CREB signaling are regulated by quercetin in ARPE-19 cells.	Quercetin	137-146	mitogen-activated protein kinase 14	Homo sapiens	74-77
25662315-7	2015	In addition, we probed the signaling behind the effects and observed that p38 and ERK MAPK pathways, and CREB signaling are regulated by quercetin in ARPE-19 cells.	Quercetin	137-146	mitogen-activated protein kinase 1	Homo sapiens	82-85
25662315-7	2015	In addition, we probed the signaling behind the effects and observed that p38 and ERK MAPK pathways, and CREB signaling are regulated by quercetin in ARPE-19 cells.	Quercetin	137-146	mitogen-activated protein kinase 1	Homo sapiens	86-90
25895265-10	2015	Anti obesity drug, orlistat was also incorporated in the studyto prove that quercetin could be a potent inhibitorfor FTO.	Quercetin	76-85	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	117-120
25830055-0	2015	Quercetin Down-regulates IL-6/STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Nonsmall- cell Lung-cancer Cell Line, A549.	Quercetin	0-9	interleukin 6	Homo sapiens	25-29
25830055-0	2015	Quercetin Down-regulates IL-6/STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Nonsmall- cell Lung-cancer Cell Line, A549.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	30-36
25830055-5	2015	RESULTS: Results revealed that quercetin could induce apoptosis in A549 cells through mitochondrial depolarization by causing an imbalance in B-cell lymphoma 2/ Bcl2 Antagonist X (Bcl2/Bax) ratio and by down-regulating the interleukine-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway.	Quercetin	31-40	BCL2 apoptosis regulator	Homo sapiens	161-165
25830055-5	2015	RESULTS: Results revealed that quercetin could induce apoptosis in A549 cells through mitochondrial depolarization by causing an imbalance in B-cell lymphoma 2/ Bcl2 Antagonist X (Bcl2/Bax) ratio and by down-regulating the interleukine-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway.	Quercetin	31-40	BCL2 apoptosis regulator	Homo sapiens	180-184
25830055-5	2015	RESULTS: Results revealed that quercetin could induce apoptosis in A549 cells through mitochondrial depolarization by causing an imbalance in B-cell lymphoma 2/ Bcl2 Antagonist X (Bcl2/Bax) ratio and by down-regulating the interleukine-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway.	Quercetin	31-40	BCL2 associated X, apoptosis regulator	Homo sapiens	185-188
25830055-5	2015	RESULTS: Results revealed that quercetin could induce apoptosis in A549 cells through mitochondrial depolarization by causing an imbalance in B-cell lymphoma 2/ Bcl2 Antagonist X (Bcl2/Bax) ratio and by down-regulating the interleukine-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway.	Quercetin	31-40	signal transducer and activator of transcription 3	Homo sapiens	223-288
25830055-5	2015	RESULTS: Results revealed that quercetin could induce apoptosis in A549 cells through mitochondrial depolarization by causing an imbalance in B-cell lymphoma 2/ Bcl2 Antagonist X (Bcl2/Bax) ratio and by down-regulating the interleukine-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway.	Quercetin	31-40	interleukin 6	Homo sapiens	290-294
25830055-5	2015	RESULTS: Results revealed that quercetin could induce apoptosis in A549 cells through mitochondrial depolarization by causing an imbalance in B-cell lymphoma 2/ Bcl2 Antagonist X (Bcl2/Bax) ratio and by down-regulating the interleukine-6/signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway.	Quercetin	31-40	signal transducer and activator of transcription 3	Homo sapiens	295-300
25830055-6	2015	An analysis of the data revealed that quercetin could block nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity at early hours, which might cause a down-regulation of the IL-6 titer, and the IL-6 expression, in turn, could inhibit p-STAT3 expression.	Quercetin	38-47	nuclear factor kappa B subunit 1	Homo sapiens	124-133
25830055-6	2015	An analysis of the data revealed that quercetin could block nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity at early hours, which might cause a down-regulation of the IL-6 titer, and the IL-6 expression, in turn, could inhibit p-STAT3 expression.	Quercetin	38-47	interleukin 6	Homo sapiens	203-207
25830055-6	2015	An analysis of the data revealed that quercetin could block nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity at early hours, which might cause a down-regulation of the IL-6 titer, and the IL-6 expression, in turn, could inhibit p-STAT3 expression.	Quercetin	38-47	interleukin 6	Homo sapiens	223-227
25830055-6	2015	An analysis of the data revealed that quercetin could block nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activity at early hours, which might cause a down-regulation of the IL-6 titer, and the IL-6 expression, in turn, could inhibit p-STAT3 expression.	Quercetin	38-47	signal transducer and activator of transcription 3	Homo sapiens	265-270
25547049-5	2015	Interestingly, oral supplementation of quercetin (15mg/kg/day) prior to APAP intoxication dramatically reduced APAP-induced hepatorenal toxicity as evidenced by measuring serum lipid profile, total protein, urea, creatinine, ALT, AST, ALP, G-GT and liver tissue content of TC and TG.	Quercetin	39-48	PDZ and LIM domain 3	Rattus norvegicus	235-238
24666303-0	2015	2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent.	Quercetin	42-51	aldo-keto reductase family 1 member B1	Rattus norvegicus	71-87
24666303-2	2015	In this study, the inhibition of rat lens aldose reductase by 3,7-di-hydroxy-2-[4-(2-chloro-1,4-naphthoquinone-3-yloxy)-3-hydroxy-phenyl]-5-hydroxy-chromen-4-one (compound 1), was studied in greater detail in comparison with the parent quercetin (compound 2).	Quercetin	236-245	aldo-keto reductase family 1 member B1	Rattus norvegicus	42-58
25359171-4	2015	Interestingly, separate as well as combined supplementation of curcumin (60 mg/kg body weight) and quercetin (40 mg/kg body weight) to BP-treated animals resulted in a significant decrease in the protein expression of Bcl-2 but caused a significant increase in the protein expression of Bax along with a noticeable improvement in the number of apoptotic cells.	Quercetin	99-108	B cell leukemia/lymphoma 2	Mus musculus	218-223
25359171-4	2015	Interestingly, separate as well as combined supplementation of curcumin (60 mg/kg body weight) and quercetin (40 mg/kg body weight) to BP-treated animals resulted in a significant decrease in the protein expression of Bcl-2 but caused a significant increase in the protein expression of Bax along with a noticeable improvement in the number of apoptotic cells.	Quercetin	99-108	BCL2-associated X protein	Mus musculus	287-290
25359171-5	2015	Also, supplementation with curcumin and quercetin separately to BP-treated mice brought a significant improvement in the enzyme activities of caspase 9 as well as caspase 3 but the improvement was more pronounced following combined treatment.	Quercetin	40-49	caspase 9	Mus musculus	142-151
25359171-5	2015	Also, supplementation with curcumin and quercetin separately to BP-treated mice brought a significant improvement in the enzyme activities of caspase 9 as well as caspase 3 but the improvement was more pronounced following combined treatment.	Quercetin	40-49	caspase 3	Mus musculus	163-172
25662315-7	2015	In addition, we probed the signaling behind the effects and observed that p38 and ERK MAPK pathways, and CREB signaling are regulated by quercetin in ARPE-19 cells.	Quercetin	137-146	cAMP responsive element binding protein 1	Homo sapiens	105-109
25578686-10	2015	Quercetin indeed showed a renal protective effect by increasing glutathione reductase and peroxidase levels and reducing MDA levels.	Quercetin	0-9	glutathione-disulfide reductase	Rattus norvegicus	64-85
25578686-12	2015	TiO2 induces significantly the glutathione reductase expression and it can be down-regulated by quercetin.	Quercetin	96-105	glutathione-disulfide reductase	Rattus norvegicus	31-52
26118109-9	2015	BCRP inhibitor quercetin (50 mumol x L(-1)) significantly increased the accumulation of flecainide in MDCKII-BCRP cells (P &lt; 0.05).	Quercetin	15-24	ATP binding cassette subfamily G member 2	Canis lupus familiaris	0-4
26118109-9	2015	BCRP inhibitor quercetin (50 mumol x L(-1)) significantly increased the accumulation of flecainide in MDCKII-BCRP cells (P &lt; 0.05).	Quercetin	15-24	ATP binding cassette subfamily G member 2	Canis lupus familiaris	109-113
25203460-4	2015	Quercetin-induced cardiotoxicity was assessed by monitoring MTT reduction, lactate dehydrogenase (LDH) release, caspase 3 activity and reactive oxygen species production after prolonged flavonoid exposure (72 hr).	Quercetin	0-9	caspase 3	Rattus norvegicus	112-121
25203460-8	2015	Quercetin attenuated H2 O2 -induced activation of ERK1/2, PKB, p38 MAPK and JNK, but inhibitors of these kinases did not modulate quercetin-induced protection or H2 O2 -induced cell death.	Quercetin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	50-56
25203460-8	2015	Quercetin attenuated H2 O2 -induced activation of ERK1/2, PKB, p38 MAPK and JNK, but inhibitors of these kinases did not modulate quercetin-induced protection or H2 O2 -induced cell death.	Quercetin	0-9	mitogen activated protein kinase 14	Rattus norvegicus	63-66
25203460-8	2015	Quercetin attenuated H2 O2 -induced activation of ERK1/2, PKB, p38 MAPK and JNK, but inhibitors of these kinases did not modulate quercetin-induced protection or H2 O2 -induced cell death.	Quercetin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	67-71
25203460-8	2015	Quercetin attenuated H2 O2 -induced activation of ERK1/2, PKB, p38 MAPK and JNK, but inhibitors of these kinases did not modulate quercetin-induced protection or H2 O2 -induced cell death.	Quercetin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	76-79
25619802-0	2015	Quercetin Induces Antiproliferative Activity Against Human Hepatocellular Carcinoma (HepG2) Cells by Suppressing Specificity Protein 1 (Sp1).	Quercetin	0-9	Sp1 transcription factor	Homo sapiens	113-134
25619802-2	2015	However, the apoptotic effect of quercetin in hepatocellular carcinoma HepG2 cells via regulation of specificity protein 1 (Sp1) has not been studied.	Quercetin	33-42	Sp1 transcription factor	Homo sapiens	101-122
25354548-0	2015	Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA-21.	Quercetin	15-24	microRNA 21	Homo sapiens	110-121
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Quercetin	252-261	ATP binding cassette subfamily B member 1	Homo sapiens	25-29
25687049-0	2015	[Effect of quercetin on doxorubicin-induced expression of MDR1 gene in HL-60 cells].	Quercetin	11-20	ATP binding cassette subfamily B member 1	Homo sapiens	58-62
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Quercetin	252-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-68
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Quercetin	279-288	ATP binding cassette subfamily B member 1	Homo sapiens	120-124
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Quercetin	279-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Quercetin	279-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
25687049-3	2015	Recent studies showed Dox-induced coexpression of COX2 and MDR1 genes in human leukaemia cells, and whether Dox-induced MDR1 up-regulation in acute leukaemia cells is dependent on COX2-transcriptional activity and thus might be overcome or prevented with COX2-promotor inhibitor quercetin interfering with COX2 expression and activity.	Quercetin	279-288	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184
25687049-4	2015	This study was purposed to investigate the impacts of quercetin on Dox-induced mRNA expression of MDR1 and COX2 genes in HL-60 leukemia cells.	Quercetin	54-63	ATP binding cassette subfamily B member 1	Homo sapiens	98-102
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Quercetin	252-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
25687049-4	2015	This study was purposed to investigate the impacts of quercetin on Dox-induced mRNA expression of MDR1 and COX2 genes in HL-60 leukemia cells.	Quercetin	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-111
25687049-6	2015	RESULTS: The incubation of HL-60 cells with Dox not only up-regulated MDR1 mRNA, but also COX2 mRNA expression, and after co-incubation with quercetin or celecoxib, Dox-induced overexpression of MDR1 and COX2 mRNA were reduced by quercetin, not by celecoxib, whereas PGE2 release was significantly decreased with subsequent enhancement of Dox cytotoxic efficacy by both of them.	Quercetin	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-94
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Quercetin	252-261	ATP binding cassette subfamily B member 1	Homo sapiens	167-171
25687049-6	2015	RESULTS: The incubation of HL-60 cells with Dox not only up-regulated MDR1 mRNA, but also COX2 mRNA expression, and after co-incubation with quercetin or celecoxib, Dox-induced overexpression of MDR1 and COX2 mRNA were reduced by quercetin, not by celecoxib, whereas PGE2 release was significantly decreased with subsequent enhancement of Dox cytotoxic efficacy by both of them.	Quercetin	141-150	ATP binding cassette subfamily B member 1	Homo sapiens	195-199
25687049-6	2015	RESULTS: The incubation of HL-60 cells with Dox not only up-regulated MDR1 mRNA, but also COX2 mRNA expression, and after co-incubation with quercetin or celecoxib, Dox-induced overexpression of MDR1 and COX2 mRNA were reduced by quercetin, not by celecoxib, whereas PGE2 release was significantly decreased with subsequent enhancement of Dox cytotoxic efficacy by both of them.	Quercetin	141-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	204-208
25687049-7	2015	CONCLUSIONS: Dox-induced MDR1 up-regulation may be dependent on COX2-transcriptional activity, not PGE2, suggesting that the existence of causal link between COX2 and MDR1 expression induced by Dox, and modulation of COX2 transcriptional expression by quercetin would not only sensitize leukemia cells to Dox, but also prevent the acquisition of MDR during chemotherapy.	Quercetin	252-261	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	158-162
25629520-5	2015	The results showed that quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and suppresses oxidative stress and inflammatory responses induced by radiation exposure, suggesting that quercetin intake may be an effective method to treat impaired salivary secretion.	Quercetin	24-33	aquaporin 5	Mus musculus	43-54
25629520-5	2015	The results showed that quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and suppresses oxidative stress and inflammatory responses induced by radiation exposure, suggesting that quercetin intake may be an effective method to treat impaired salivary secretion.	Quercetin	24-33	aquaporin 5	Mus musculus	56-60
25629520-5	2015	The results showed that quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and suppresses oxidative stress and inflammatory responses induced by radiation exposure, suggesting that quercetin intake may be an effective method to treat impaired salivary secretion.	Quercetin	199-208	aquaporin 5	Mus musculus	43-54
25629520-5	2015	The results showed that quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and suppresses oxidative stress and inflammatory responses induced by radiation exposure, suggesting that quercetin intake may be an effective method to treat impaired salivary secretion.	Quercetin	199-208	aquaporin 5	Mus musculus	56-60
25580686-3	2015	In this study, the expression level of TRAIL-R1 on murine RAW264.7 macrophages in the presence of selected flavonols: galangin, kaempferol, kaempferide and quercetin, which differ from their phenyl ring substituents, were studied.	Quercetin	156-165	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	39-44
25486072-6	2015	The energetically favored Zn chelation sites of the 1:1 complex were found to be either the C-3 O(-) and CO-4 or C-5 O(-) and CO-4 sites, depending on the functional used, for quercetin and the C-5 O(-) and CO-4 sites for luteolin.	Quercetin	176-185	complement C5	Homo sapiens	113-116
25486072-2	2015	Very sharp phenolic OH (1)H resonances in DMSO-d6 were observed for both free and complexed quercetin which allowed (i) the unequivocal assignment with the combined use of (1)H-(13)C HSQC and HMBC experiments and (ii) the determination of complexation sites which were found to be the CO-4 carbonyl oxygen and the deprotonated C-5 OH group of quercetin and CO-4 carbonyl oxygen and the deprotonated C-5 OH group of luteolin.	Quercetin	92-101	complement C5	Homo sapiens	327-330
25486072-2	2015	Very sharp phenolic OH (1)H resonances in DMSO-d6 were observed for both free and complexed quercetin which allowed (i) the unequivocal assignment with the combined use of (1)H-(13)C HSQC and HMBC experiments and (ii) the determination of complexation sites which were found to be the CO-4 carbonyl oxygen and the deprotonated C-5 OH group of quercetin and CO-4 carbonyl oxygen and the deprotonated C-5 OH group of luteolin.	Quercetin	92-101	complement C5	Homo sapiens	399-402
25486072-4	2015	DFT calculations of the 1:1 complex in the gas phase demonstrated that the C-3 O(-) and CO-4 sites are favored for quercetin at both GGA and LDA approximations and the C-5 O(-) and CO-4 groups of luteolin at the LDA approximation.	Quercetin	115-124	complement C3	Homo sapiens	75-78
25612678-0	2015	Quercetin Increase the Chemosensitivity of Breast Cancer Cells to Doxorubicin Via PTEN/Akt Pathway.	Quercetin	0-9	phosphatase and tensin homolog	Homo sapiens	82-86
25765278-3	2015	The pn-MWCNTs modified electrode (pn-MWCNTs/GCE) was further explored for the analysis of quercetin and kaempferol in diluted blood serum and average recovery rates of 96.91 and 100.5% were obtained, respectively.	Quercetin	90-99	aminomethyltransferase	Homo sapiens	44-47
26351625-7	2015	Regarding the analgesic mechanisms of quercetin, it inhibited the production of hyperalgesic cytokines IL-1beta and TNFalpha and decreased neutrophil recruitment (myeloperoxidase activity) and oxidative stress.	Quercetin	38-47	interleukin 1 beta	Mus musculus	103-111
26351625-7	2015	Regarding the analgesic mechanisms of quercetin, it inhibited the production of hyperalgesic cytokines IL-1beta and TNFalpha and decreased neutrophil recruitment (myeloperoxidase activity) and oxidative stress.	Quercetin	38-47	tumor necrosis factor	Mus musculus	116-124
25612678-0	2015	Quercetin Increase the Chemosensitivity of Breast Cancer Cells to Doxorubicin Via PTEN/Akt Pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	87-90
25612678-7	2015	However, co-treatment with PTEN inhibitor bpV (HOpic) could revert the effects of Que on Dox.	Quercetin	82-85	phosphatase and tensin homolog	Homo sapiens	27-31
26419090-12	2015	Inhibition was reversible and competitive for most enzymes; mechanism-based inhibition was evident for UGT2B7 and SULT2A1 with regard to quercetin and for SULT1E1 with regard to kaempferol.	Quercetin	137-146	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	103-109
24895146-5	2015	The role of the glycosides attached to quercetin in the regulation of gamma-aminobutyric acid class C (GABAC) receptor channel activity has not been determined.	Quercetin	39-48	gamma-aminobutyric acid type A receptor subunit rho1	Homo sapiens	70-118
24895146-6	2015	In the present study, we examined the effects of quercetin glycosides on GABAC receptor channel activity by expressing human GABAC alone in Xenopus oocytes using a two-electrode voltage clamp technique and also compared the effects of quercetin glycosides with quercetin.	Quercetin	49-58	gamma-aminobutyric acid type A receptor subunit rho1	Homo sapiens	73-87
24895146-10	2015	These results indicate that quercetin and its glycosides regulate GABAC receptor channel activity through interaction with a different site from that of GABA, and that the number of carbohydrate attached to quercetin might play an important role in the regulation of GABAC receptor channel activity.	Quercetin	28-37	gamma-aminobutyric acid type A receptor subunit rho1	Homo sapiens	66-80
24895146-10	2015	These results indicate that quercetin and its glycosides regulate GABAC receptor channel activity through interaction with a different site from that of GABA, and that the number of carbohydrate attached to quercetin might play an important role in the regulation of GABAC receptor channel activity.	Quercetin	28-37	gamma-aminobutyric acid type A receptor subunit rho1	Homo sapiens	267-281
24895146-10	2015	These results indicate that quercetin and its glycosides regulate GABAC receptor channel activity through interaction with a different site from that of GABA, and that the number of carbohydrate attached to quercetin might play an important role in the regulation of GABAC receptor channel activity.	Quercetin	207-216	gamma-aminobutyric acid type A receptor subunit rho1	Homo sapiens	267-281
26419090-12	2015	Inhibition was reversible and competitive for most enzymes; mechanism-based inhibition was evident for UGT2B7 and SULT2A1 with regard to quercetin and for SULT1E1 with regard to kaempferol.	Quercetin	137-146	sulfotransferase family 2A member 1	Homo sapiens	114-121
26558284-4	2015	The mRNA expression of methionine synthase was significantly increased after methionine or methionine plus quercetin supplementation, while its enzymatic activity was significantly increased after methionine plus quercetin supplementation.	Quercetin	107-116	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	23-42
26320505-15	2015	CME and CEE had high contents of gallic acid and quercetin.	Quercetin	49-58	guided entry of tail-anchored proteins factor 4	Homo sapiens	8-11
26328486-5	2015	Additionally, the DOX-elicited cytotoxicity was lowered by overexpression of CBR1 and inversely strengthened by knockdown of the enzyme using small interfering RNA or pretreating with the specific inhibitor quercetin, which also reduced the DOX refractoriness of the two resistant cells.	Quercetin	207-216	carbonyl reductase 1	Homo sapiens	77-81
25854382-6	2015	Results of IHC and Western blotting demonstrated the expression level of NF-kappaB to be decreased and that of an inhibitor of NF-kappaB (Ikappab-alpha) to be increased by the quercetin intervention compared with the radiation control group.	Quercetin	176-185	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82
25854382-6	2015	Results of IHC and Western blotting demonstrated the expression level of NF-kappaB to be decreased and that of an inhibitor of NF-kappaB (Ikappab-alpha) to be increased by the quercetin intervention compared with the radiation control group.	Quercetin	176-185	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	127-136
25854382-6	2015	Results of IHC and Western blotting demonstrated the expression level of NF-kappaB to be decreased and that of an inhibitor of NF-kappaB (Ikappab-alpha) to be increased by the quercetin intervention compared with the radiation control group.	Quercetin	176-185	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	138-151
25854382-7	2015	Numbers of JNK/SAPK, p38 and p44/p42 positive inflammatory cells were decreased in the radiation+quercetin injection group (P&lt;0.05).	Quercetin	97-106	mitogen-activated protein kinase 8	Mus musculus	11-19
25854382-7	2015	Numbers of JNK/SAPK, p38 and p44/p42 positive inflammatory cells were decreased in the radiation+quercetin injection group (P&lt;0.05).	Quercetin	97-106	mitogen-activated protein kinase 14	Mus musculus	21-24
25854382-7	2015	Numbers of JNK/SAPK, p38 and p44/p42 positive inflammatory cells were decreased in the radiation+quercetin injection group (P&lt;0.05).	Quercetin	97-106	mitogen-activated protein kinase 3	Mus musculus	29-32
25854382-7	2015	Numbers of JNK/SAPK, p38 and p44/p42 positive inflammatory cells were decreased in the radiation+quercetin injection group (P&lt;0.05).	Quercetin	97-106	cyclin-dependent kinase 20	Mus musculus	33-36
25854382-8	2015	CONCLUSIONS: Quercetin may play a radio-protective role in mice lung via suppression of NF-kappaB and MAPK pathways.	Quercetin	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97
25854382-8	2015	CONCLUSIONS: Quercetin may play a radio-protective role in mice lung via suppression of NF-kappaB and MAPK pathways.	Quercetin	13-22	mitogen-activated protein kinase 3	Mus musculus	102-106
26558284-4	2015	The mRNA expression of methionine synthase was significantly increased after methionine or methionine plus quercetin supplementation, while its enzymatic activity was significantly increased after methionine plus quercetin supplementation.	Quercetin	213-222	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	23-42
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	127-136	cystathionine beta synthase	Rattus norvegicus	46-73
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	127-136	cystathionine gamma-lyase	Rattus norvegicus	78-103
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	127-136	cystathionine beta synthase	Rattus norvegicus	246-273
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	153-162	cystathionine beta synthase	Rattus norvegicus	46-73
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	153-162	cystathionine gamma-lyase	Rattus norvegicus	78-103
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	153-162	cystathionine beta synthase	Rattus norvegicus	246-273
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	153-162	cystathionine beta synthase	Rattus norvegicus	46-73
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	153-162	cystathionine gamma-lyase	Rattus norvegicus	78-103
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	153-162	cystathionine beta synthase	Rattus norvegicus	246-273
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	153-162	cystathionine beta synthase	Rattus norvegicus	46-73
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	153-162	cystathionine gamma-lyase	Rattus norvegicus	78-103
26558284-5	2015	The mRNA expression and enzymatic activity of cystathionine beta-synthase and cystathionine gamma-lyase were upregulated after quercetin, methionine, or quercetin plus methionine treatment and a more significant increase was observed for hepatic cystathionine beta-synthase in the methionine plus quercetin treated rats, suggesting an interaction between methionine and quercetin.	Quercetin	153-162	cystathionine beta synthase	Rattus norvegicus	246-273
25896587-6	2015	When inhibiting the miR-34a, the sensitivity of the cells to quercetin decreased and the expression of the SIRT1 was up-regulated, but the acetylation of p53 and the expression of some genes related to p53 down-regulated.	Quercetin	61-70	tumor protein p53	Homo sapiens	202-205
25685784-7	2015	Quercetin competitively inhibited CYP2E1 and CYP1A activity in the microsomes from male pigs and irreversibly CY3A in female pigs.	Quercetin	0-9	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	34-40
25685784-10	2015	Taken together, our results suggest that the flavonoids myricetin, isorhamnetin, and quercetin may affect the activities of porcine CYP1A, CYP3A, and CYP2E1 in a gender-dependent manner.	Quercetin	85-94	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	150-156
26004618-10	2015	Curcumin and quercetin treatments to mice were able to decrease significantly the levels of LPO, ROS, as well as activities of SOD, GST.	Quercetin	13-22	lactoperoxidase	Mus musculus	92-95
25967872-11	2015	Furthermore, quercetin inhibited both Ca(2+)-activated Cl(-) channels (TMEM16A, ANO1) and TRPM7 channels.	Quercetin	13-22	anoctamin 1, calcium activated chloride channel	Mus musculus	71-78
25967872-11	2015	Furthermore, quercetin inhibited both Ca(2+)-activated Cl(-) channels (TMEM16A, ANO1) and TRPM7 channels.	Quercetin	13-22	anoctamin 1, calcium activated chloride channel	Mus musculus	80-84
25967872-11	2015	Furthermore, quercetin inhibited both Ca(2+)-activated Cl(-) channels (TMEM16A, ANO1) and TRPM7 channels.	Quercetin	13-22	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	90-95
25967872-14	2015	CONCLUSIONS: Quercetin inhibited ICC pacemaker activities by inhibiting TRPM7 and ANO1 via opioid receptor signaling pathways in cultured murine ICCs.	Quercetin	13-22	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	72-77
25967872-14	2015	CONCLUSIONS: Quercetin inhibited ICC pacemaker activities by inhibiting TRPM7 and ANO1 via opioid receptor signaling pathways in cultured murine ICCs.	Quercetin	13-22	anoctamin 1, calcium activated chloride channel	Mus musculus	82-86
25678313-3	2015	Quercetin and chrysin are naturally occurring flavonoids, reported as modulators of P-gp and DMEs.	Quercetin	0-9	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	84-88
25678313-10	2015	Our findings suggested that the quercetin and chrysin might be inhibited the P-gp and metabolism of paracetamol; thereby increased the systemic exposure of paracetamol.	Quercetin	32-41	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	77-81
25678313-11	2015	Further studies are needed to evaluate whether the quercetin or chrysin are involved in the formation of NAPQI by CYP2E1 or not on isolated rat hepatocytes or using cell lines.	Quercetin	51-60	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	114-120
25896587-0	2015	The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis.	Quercetin	48-57	tumor protein p53	Homo sapiens	4-7
25896587-0	2015	The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis.	Quercetin	48-57	microRNA 34a	Homo sapiens	8-15
25896587-0	2015	The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis.	Quercetin	48-57	sirtuin 1	Homo sapiens	16-21
25896587-5	2015	RESULTS: miR-34a was up-regulated in HepG2 cells treated by quercetin exhibiting wild-type p53.	Quercetin	60-69	microRNA 34a	Homo sapiens	9-16
25896587-5	2015	RESULTS: miR-34a was up-regulated in HepG2 cells treated by quercetin exhibiting wild-type p53.	Quercetin	60-69	tumor protein p53	Homo sapiens	91-94
25896587-6	2015	When inhibiting the miR-34a, the sensitivity of the cells to quercetin decreased and the expression of the SIRT1 was up-regulated, but the acetylation of p53 and the expression of some genes related to p53 down-regulated.	Quercetin	61-70	microRNA 34a	Homo sapiens	20-27
26633020-3	2015	The catechol moiety of Cat, Que, and rutin plays an essential role in concerted proton-coupled electron transfer (PCET) to HO2( ) derived from O2( -) to give H2O2 and the corresponding o-benzoquinone radical anions.	Quercetin	28-31	heme oxygenase 2	Homo sapiens	123-126
25478737-3	2015	The present study was aimed to evaluate the potential of aminopropyl functionalized mesoporous silica nanoparticles (NH2-MSN) as topical carrier system for quercetin delivery.	Quercetin	156-165	moesin	Homo sapiens	121-124
25478737-9	2015	At a concentration 60 muM the complex with NH2-MSN was more effective than quercetin alone, causing about 50% inhibition of cell proliferation.	Quercetin	75-84	moesin	Homo sapiens	47-50
26273314-0	2015	Allium cepa L. and Quercetin Inhibit RANKL/Porphyromonas gingivalis LPS-Induced Osteoclastogenesis by Downregulating NF-kappaB Signaling Pathway.	Quercetin	19-28	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	37-42
26626251-5	2015	RESULTS: EpiDerm  treated topically with quercetin significantly decreased MMP-1 secretion induced by UVA (100 microM) or UVB (200 microM) and TNF-a secretion was significantly reduced at 100 microM quercetin for both UVA and UVB radiation.	Quercetin	41-50	matrix metallopeptidase 1	Homo sapiens	75-80
25557727-6	2015	Quercetin is a flavonol with anti-inflammatory and antioxidant effects and is also an activator of peroxisome proliferator-activated receptor gamma coactivator 1alpha capable of antioxidant upregulation, mitochondrial biogenesis and prevention of cardiac complications.	Quercetin	0-9	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	99-166
25557727-15	2015	Six months of quercetin feeding increased a mitochondrial biomarker, antioxidant protein and utrophin and decreased matrix metalloproteinase 9 in young mice.	Quercetin	14-23	utrophin	Mus musculus	93-101
25557727-15	2015	Six months of quercetin feeding increased a mitochondrial biomarker, antioxidant protein and utrophin and decreased matrix metalloproteinase 9 in young mice.	Quercetin	14-23	matrix metallopeptidase 9	Mus musculus	116-142
25245014-0	2015	Blockage of Wnt/beta-catenin signaling by quercetin reduces survival and proliferation of B-1 cells in vitro.	Quercetin	42-51	catenin beta 1	Homo sapiens	16-28
25245014-7	2015	Furthermore, the quercetin treatment diminishes IL-6 production by peritoneal cells, a cytokine important to the maintenance of B-1 cells in vitro.	Quercetin	17-26	interleukin 6	Homo sapiens	48-52
25245014-8	2015	Importantly, the IL-6 addition to B-1 cell culture prevents cells from apoptosis, even in the presence of quercetin.	Quercetin	106-115	interleukin 6	Homo sapiens	17-21
24903407-4	2015	Quercetin and taxifolin (natural polyphenols) efficiently bound to hydrophobic groove of Bcl-2 and altered the structure by inducing conformational changes.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	89-94
24903407-6	2015	Taxifolin and quercetin were found to dissociate the Bcl-2-Bax complex during 12 ns MD simulation.	Quercetin	14-23	BCL2 apoptosis regulator	Homo sapiens	53-58
24903407-6	2015	Taxifolin and quercetin were found to dissociate the Bcl-2-Bax complex during 12 ns MD simulation.	Quercetin	14-23	BCL2 associated X, apoptosis regulator	Homo sapiens	59-62
24903407-7	2015	The effect of taxifolin and quercetin was, further validated by the MD simulation of ligand-unbound Bcl-2-Bax which showed stability during the simulation.	Quercetin	28-37	BCL2 apoptosis regulator	Homo sapiens	100-105
24903407-7	2015	The effect of taxifolin and quercetin was, further validated by the MD simulation of ligand-unbound Bcl-2-Bax which showed stability during the simulation.	Quercetin	28-37	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
26609312-0	2015	The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue.	Quercetin	35-44	sirtuin 1	Rattus norvegicus	149-155
26609312-0	2015	The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue.	Quercetin	35-44	sirtuin 2	Rattus norvegicus	160-166
26609312-9	2015	RSV + QRC administration improved the serum health parameters modified by MetS and upregulate SIRT 1 and SIRT 2 expression in white abdominal tissue in MetS animals.	Quercetin	6-9	sirtuin 1	Rattus norvegicus	94-100
26609312-9	2015	RSV + QRC administration improved the serum health parameters modified by MetS and upregulate SIRT 1 and SIRT 2 expression in white abdominal tissue in MetS animals.	Quercetin	6-9	sirtuin 2	Rattus norvegicus	105-111
26626251-5	2015	RESULTS: EpiDerm  treated topically with quercetin significantly decreased MMP-1 secretion induced by UVA (100 microM) or UVB (200 microM) and TNF-a secretion was significantly reduced at 100 microM quercetin for both UVA and UVB radiation.	Quercetin	199-208	tumor necrosis factor	Homo sapiens	143-148
25145901-12	2015	Quercetin decreased Hsp70 and resulted again in increased H2O2-induced apoptosis.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	20-25
25658812-0	2015	Quercetin regresses Dalton"s lymphoma growth via suppression of PI3K/AKT signaling leading to upregulation of p53 and decrease in energy metabolism.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	69-72
25339115-11	2015	The present study demonstrated a quercetin-induced reduction of the oxidative stress-associated increase in Nrf2 expression that may be useful for preventing cancer cell survival in response to ionizing radiation exposure.	Quercetin	33-42	NFE2 like bZIP transcription factor 2	Rattus norvegicus	108-112
25339540-6	2015	In addition, treatment of K562/ADR cells with quercetin alone or in combination with ADR resulted in loss of mitochondrial membrane potential, activation of caspase-8, -9 and -3, reduced expression of the anti-apoptotic proteins B-cell lymphoma (Bcl)-2 and Bcl-extra large and enhanced expression of the pro-apoptotic proteins Bcl-2-interacting mediator of cell death, Bcl-2-associated death promoter and Bcl-2-associated X protein in the cells.	Quercetin	46-55	caspase 8	Homo sapiens	157-177
25339540-6	2015	In addition, treatment of K562/ADR cells with quercetin alone or in combination with ADR resulted in loss of mitochondrial membrane potential, activation of caspase-8, -9 and -3, reduced expression of the anti-apoptotic proteins B-cell lymphoma (Bcl)-2 and Bcl-extra large and enhanced expression of the pro-apoptotic proteins Bcl-2-interacting mediator of cell death, Bcl-2-associated death promoter and Bcl-2-associated X protein in the cells.	Quercetin	46-55	BCL2 apoptosis regulator	Homo sapiens	229-252
25339540-6	2015	In addition, treatment of K562/ADR cells with quercetin alone or in combination with ADR resulted in loss of mitochondrial membrane potential, activation of caspase-8, -9 and -3, reduced expression of the anti-apoptotic proteins B-cell lymphoma (Bcl)-2 and Bcl-extra large and enhanced expression of the pro-apoptotic proteins Bcl-2-interacting mediator of cell death, Bcl-2-associated death promoter and Bcl-2-associated X protein in the cells.	Quercetin	46-55	BCL2 like 11	Homo sapiens	327-367
25339540-6	2015	In addition, treatment of K562/ADR cells with quercetin alone or in combination with ADR resulted in loss of mitochondrial membrane potential, activation of caspase-8, -9 and -3, reduced expression of the anti-apoptotic proteins B-cell lymphoma (Bcl)-2 and Bcl-extra large and enhanced expression of the pro-apoptotic proteins Bcl-2-interacting mediator of cell death, Bcl-2-associated death promoter and Bcl-2-associated X protein in the cells.	Quercetin	46-55	BCL2 apoptosis regulator	Homo sapiens	327-332
25339540-6	2015	In addition, treatment of K562/ADR cells with quercetin alone or in combination with ADR resulted in loss of mitochondrial membrane potential, activation of caspase-8, -9 and -3, reduced expression of the anti-apoptotic proteins B-cell lymphoma (Bcl)-2 and Bcl-extra large and enhanced expression of the pro-apoptotic proteins Bcl-2-interacting mediator of cell death, Bcl-2-associated death promoter and Bcl-2-associated X protein in the cells.	Quercetin	46-55	BCL2 apoptosis regulator	Homo sapiens	369-374
25339540-8	2015	In addition, the expression of P-glycoprotein was significantly decreased following treatment with quercetin alone or in combination with ADR.	Quercetin	99-108	ATP binding cassette subfamily B member 1	Homo sapiens	31-45
25481090-0	2015	Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	65-70
25481090-0	2015	Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells.	Quercetin	0-9	fibronectin 1	Homo sapiens	75-86
25481090-0	2015	Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	95-98
25481090-0	2015	Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	103-106
25481090-6	2015	beta-galactosidase staining, DNA staining and Annexin V-EGF/PI double staining assays demonstrated that quercetin promoted cell senescence and apoptosis.	Quercetin	104-113	annexin A5	Homo sapiens	46-55
25481090-7	2015	In addition, the protein levels of p-AKT, p-ERK, Bcl-2, matrix metallopeptidase 9 (MMP-9) and fibronectin (FN) were significantly reduced following quercetin treatment.	Quercetin	148-157	AKT serine/threonine kinase 1	Homo sapiens	37-40
25481090-7	2015	In addition, the protein levels of p-AKT, p-ERK, Bcl-2, matrix metallopeptidase 9 (MMP-9) and fibronectin (FN) were significantly reduced following quercetin treatment.	Quercetin	148-157	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	42-47
25481090-7	2015	In addition, the protein levels of p-AKT, p-ERK, Bcl-2, matrix metallopeptidase 9 (MMP-9) and fibronectin (FN) were significantly reduced following quercetin treatment.	Quercetin	148-157	BCL2 apoptosis regulator	Homo sapiens	49-54
25481090-7	2015	In addition, the protein levels of p-AKT, p-ERK, Bcl-2, matrix metallopeptidase 9 (MMP-9) and fibronectin (FN) were significantly reduced following quercetin treatment.	Quercetin	148-157	matrix metallopeptidase 9	Homo sapiens	56-81
25481090-7	2015	In addition, the protein levels of p-AKT, p-ERK, Bcl-2, matrix metallopeptidase 9 (MMP-9) and fibronectin (FN) were significantly reduced following quercetin treatment.	Quercetin	148-157	matrix metallopeptidase 9	Homo sapiens	83-88
25481090-7	2015	In addition, the protein levels of p-AKT, p-ERK, Bcl-2, matrix metallopeptidase 9 (MMP-9) and fibronectin (FN) were significantly reduced following quercetin treatment.	Quercetin	148-157	fibronectin 1	Homo sapiens	94-105
25481090-8	2015	Therefore, we conclude that quercetin might inhibit the viability and migration and promote the senescence and apoptosis of glioma cells by suppressing the Ras/MAPK/ERK and PI3K/AKT signalling pathways.	Quercetin	28-37	mitogen-activated protein kinase 1	Homo sapiens	165-168
25481090-8	2015	Therefore, we conclude that quercetin might inhibit the viability and migration and promote the senescence and apoptosis of glioma cells by suppressing the Ras/MAPK/ERK and PI3K/AKT signalling pathways.	Quercetin	28-37	AKT serine/threonine kinase 1	Homo sapiens	178-181
26492225-5	2015	Curcumin, berberine, and quercetin effectively downregulated pSTAT3 levels, survivin expression, and gastric cancer cells viability in a dose-dependent manner (with corresponding IC50 values of 40.3muM, 29.2muM and 37.5muM, respectively).	Quercetin	25-34	latexin	Homo sapiens	198-201
25339115-0	2015	Hepatic Nrf2 expression is altered by quercetin supplementation in X-irradiated rats.	Quercetin	38-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	8-12
25622620-5	2015	From the evaluated compounds, myricetin (5) and quercetin (6) showed the most promising results with IC50 of 4.9 and 8.2 muM, respectively, and mode of inhibition as uncompetitive on catB.	Quercetin	48-57	cathepsin B	Homo sapiens	183-187
25514492-5	2015	Apoptosis analysis showed that quercetin at 50 or 100 mumol/L induced apoptosis of KB/VCR cells by suppressing expression of Bax and inducing the expression of Caspase-3 and Bcl-2.	Quercetin	31-40	BCL2 associated X, apoptosis regulator	Homo sapiens	125-128
25514492-5	2015	Apoptosis analysis showed that quercetin at 50 or 100 mumol/L induced apoptosis of KB/VCR cells by suppressing expression of Bax and inducing the expression of Caspase-3 and Bcl-2.	Quercetin	31-40	caspase 3	Homo sapiens	160-169
25514492-5	2015	Apoptosis analysis showed that quercetin at 50 or 100 mumol/L induced apoptosis of KB/VCR cells by suppressing expression of Bax and inducing the expression of Caspase-3 and Bcl-2.	Quercetin	31-40	BCL2 apoptosis regulator	Homo sapiens	174-179
25658812-0	2015	Quercetin regresses Dalton"s lymphoma growth via suppression of PI3K/AKT signaling leading to upregulation of p53 and decrease in energy metabolism.	Quercetin	0-9	transformation related protein 53, pseudogene	Mus musculus	110-113
25658812-5	2015	The present study is focused on the role of quercetin on regulation of PI3K/AKT pathways in Dalton"s lymphoma mice.	Quercetin	44-53	thymoma viral proto-oncogene 1	Mus musculus	76-79
25658812-11	2015	The findings suggest that quercetin may contribute to lymphoma prevention by downregulating PI3K-AKT1-p53 pathway as well as by glycolytic metabolism.	Quercetin	26-35	thymoma viral proto-oncogene 1	Mus musculus	97-101
25658812-11	2015	The findings suggest that quercetin may contribute to lymphoma prevention by downregulating PI3K-AKT1-p53 pathway as well as by glycolytic metabolism.	Quercetin	26-35	transformation related protein 53, pseudogene	Mus musculus	102-105
26106459-5	2015	Treatment with quercetin decreased body weight, serum insulin, and ceruloplasmin levels as compared with untreated mice.	Quercetin	15-24	ceruloplasmin	Mus musculus	67-80
25922642-0	2015	Quercetin affects Hsp70/IRE1alpha mediated protection from death induced by endoplasmic reticulum stress.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	18-23
25922642-0	2015	Quercetin affects Hsp70/IRE1alpha mediated protection from death induced by endoplasmic reticulum stress.	Quercetin	0-9	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	24-33
25922642-3	2015	Quercetin, a major dietary flavonoid, or specific silencing affected the expression level of Hsp70 and did not allow the upregulation of inositol-requiring kinase 1alpha (IRE1alpha), the prototype ER stress sensor regulating the unfolded protein response (UPR), that protects the cells against the stress of misfolded proteins in the ER.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	93-98
25922642-6	2015	These results suggest that drugs affecting the Hsp70-IRE1alpha axis, like quercetin, or affecting directly IRE1alpha may represent an effective adjuvant antileukemia therapy.	Quercetin	74-83	heat shock protein family A (Hsp70) member 4	Homo sapiens	47-52
25922642-6	2015	These results suggest that drugs affecting the Hsp70-IRE1alpha axis, like quercetin, or affecting directly IRE1alpha may represent an effective adjuvant antileukemia therapy.	Quercetin	74-83	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	53-62
25676100-0	2015	Quercetin inhibits vascular endothelial growth factor-induced choroidal and retinal angiogenesis in vitro.	Quercetin	0-9	vascular endothelial growth factor A	Macaca mulatta	19-53
25676100-1	2015	PURPOSE: The aim of this study was to investigate the effects of quercetin on vascular endothelial growth factor (VEGF)-induced choroidal and retinal angiogenesis in vitro using a rhesus macaque choroid-retinal endothelial (RF/6A) cell line.	Quercetin	65-74	vascular endothelial growth factor A	Macaca mulatta	78-112
25676100-1	2015	PURPOSE: The aim of this study was to investigate the effects of quercetin on vascular endothelial growth factor (VEGF)-induced choroidal and retinal angiogenesis in vitro using a rhesus macaque choroid-retinal endothelial (RF/6A) cell line.	Quercetin	65-74	vascular endothelial growth factor A	Macaca mulatta	114-118
25676100-7	2015	Furthermore, the impact of quercetin"s effects on VEGF-induced activation of VEGF receptor 2 (VEGFR-2) downstream signal pathways was tested by Western blot analysis.	Quercetin	27-36	vascular endothelial growth factor A	Macaca mulatta	50-54
25676100-7	2015	Furthermore, the impact of quercetin"s effects on VEGF-induced activation of VEGF receptor 2 (VEGFR-2) downstream signal pathways was tested by Western blot analysis.	Quercetin	27-36	vascular endothelial growth factor A	Macaca mulatta	77-81
25676100-9	2015	VEGF-induced migration and tube formation of RF/6A cells were also significantly inhibited by quercetin in a dose-dependent manner.	Quercetin	94-103	vascular endothelial growth factor A	Macaca mulatta	0-4
25676100-10	2015	Quercetin inhibits VEGF-induced VEGFR-2 downstream signal pathways of RF/6A.	Quercetin	0-9	vascular endothelial growth factor A	Macaca mulatta	19-23
25676100-11	2015	CONCLUSIONS: The results show that quercetin inhibits VEGF-induced cell proliferation, migration and tube formation of RF/6A.	Quercetin	35-44	vascular endothelial growth factor A	Macaca mulatta	54-58
25676100-12	2015	We suggest that quercetin inhibits VEGF-induced choroidal and retinal angiogenesis in vitro.	Quercetin	16-25	vascular endothelial growth factor A	Macaca mulatta	35-39
25676100-13	2015	Collectively, the findings in the present study suggest that quercetin inhibits VEGF-induced choroidal and retinal angiogenesis by targeting the VEGFR-2 pathway.	Quercetin	61-70	vascular endothelial growth factor A	Macaca mulatta	80-84
26329008-0	2015	The Suppressive Effect of Quercetin on Toll-Like Receptor 7-Mediated Activation in Alveolar Macrophages.	Quercetin	26-35	toll-like receptor 7	Mus musculus	39-59
26180590-8	2015	1 microM of quercetin reduced C/EBPbeta gene expression, SREBP1 mature protein levels, and PPARgamma gene expression.	Quercetin	12-21	CCAAT enhancer binding protein beta	Homo sapiens	30-39
26180590-8	2015	1 microM of quercetin reduced C/EBPbeta gene expression, SREBP1 mature protein levels, and PPARgamma gene expression.	Quercetin	12-21	sterol regulatory element binding transcription factor 1	Homo sapiens	57-63
26180590-8	2015	1 microM of quercetin reduced C/EBPbeta gene expression, SREBP1 mature protein levels, and PPARgamma gene expression.	Quercetin	12-21	peroxisome proliferator activated receptor gamma	Homo sapiens	91-100
26180590-9	2015	10 microM of quercetin reduced LPL gene expression and PPARgamma and SREBP1c expression.	Quercetin	13-22	lipoprotein lipase	Homo sapiens	31-34
26180590-9	2015	10 microM of quercetin reduced LPL gene expression and PPARgamma and SREBP1c expression.	Quercetin	13-22	peroxisome proliferator activated receptor gamma	Homo sapiens	55-64
26180590-9	2015	10 microM of quercetin reduced LPL gene expression and PPARgamma and SREBP1c expression.	Quercetin	13-22	sterol regulatory element binding transcription factor 1	Homo sapiens	69-76
25856712-8	2015	Unaffected by other compounds, fMLP-dependent increase of [Ca(2+)]i was inhibited by quercetin and catechol (5 microM) by 32 +- 14 and 12 +- 10% (p &lt; 0.04), respectively.	Quercetin	85-94	formyl peptide receptor 1	Homo sapiens	31-35
25856712-10	2015	Catechol, quercetin, and gallic acid acted most potently reducing fMLP-LBCL by 49 +- 5, 42 +- 15, and 28 +- 18% (p &lt; 0.05), respectively.	Quercetin	10-19	formyl peptide receptor 1	Homo sapiens	66-70
25709214-2	2015	In a previous study, we have reported that quercetin stimulated glucose uptake in cultured C2C12 skeletal muscle through an insulin-independent mechanism involving adenosine monophosphate-activated protein kinase (AMPK).	Quercetin	43-52	insulin	Homo sapiens	124-131
25709214-7	2015	MATERIALS AND METHODS: L6 skeletal muscle cells, murine H4IIE and human HepG2 hepatocytes were treated with quercetin (50 muM) for 18 h. RESULTS: An 18 h treatment with quercetin (50 muM) stimulated AMPK and increased GLUT4 translocation and protein content in cultured rat L6 skeletal muscle cells.	Quercetin	108-117	solute carrier family 2 member 4	Rattus norvegicus	218-223
25709214-8	2015	On the other hand, we report that quercetin induced hepatic AMPK activation and inhibited G6pase in H4IIE hepatocytes.	Quercetin	34-43	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	90-96
26329008-5	2015	In both a mouse AM cell line (AMJ2-C11 cells) and mouse bronchoalveolar fluid cells, we demonstrated that quercetin attenuated TLR7-induced the expression of TNF-alpha and IL-6.	Quercetin	106-115	toll-like receptor 7	Mus musculus	127-131
26329008-5	2015	In both a mouse AM cell line (AMJ2-C11 cells) and mouse bronchoalveolar fluid cells, we demonstrated that quercetin attenuated TLR7-induced the expression of TNF-alpha and IL-6.	Quercetin	106-115	tumor necrosis factor	Mus musculus	158-167
26329008-5	2015	In both a mouse AM cell line (AMJ2-C11 cells) and mouse bronchoalveolar fluid cells, we demonstrated that quercetin attenuated TLR7-induced the expression of TNF-alpha and IL-6.	Quercetin	106-115	interleukin 6	Mus musculus	172-176
26329008-6	2015	In AMJ2-C11 cells, quercetin also attenuated the TLR7-induced CD40 expression; attenuated the translocation of p65; induced translocation of Nrf2 from cytosol to nucleus; and induced heme oxygenase (HO)-1 expression.	Quercetin	19-28	toll-like receptor 7	Mus musculus	49-53
26329008-6	2015	In AMJ2-C11 cells, quercetin also attenuated the TLR7-induced CD40 expression; attenuated the translocation of p65; induced translocation of Nrf2 from cytosol to nucleus; and induced heme oxygenase (HO)-1 expression.	Quercetin	19-28	CD40 antigen	Mus musculus	62-66
26329008-6	2015	In AMJ2-C11 cells, quercetin also attenuated the TLR7-induced CD40 expression; attenuated the translocation of p65; induced translocation of Nrf2 from cytosol to nucleus; and induced heme oxygenase (HO)-1 expression.	Quercetin	19-28	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	111-114
26329008-6	2015	In AMJ2-C11 cells, quercetin also attenuated the TLR7-induced CD40 expression; attenuated the translocation of p65; induced translocation of Nrf2 from cytosol to nucleus; and induced heme oxygenase (HO)-1 expression.	Quercetin	19-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	141-145
26329008-6	2015	In AMJ2-C11 cells, quercetin also attenuated the TLR7-induced CD40 expression; attenuated the translocation of p65; induced translocation of Nrf2 from cytosol to nucleus; and induced heme oxygenase (HO)-1 expression.	Quercetin	19-28	heme oxygenase 1	Mus musculus	183-204
26329008-7	2015	Notably, tin protoporphyrin IX (SnPP), an inhibitor of HO-1, also attenuated TLR7-induced transcription of the TNF-alpha and IL-6 genes, suggesting that the effect of quercetin is mediated by HO-1.	Quercetin	167-176	toll-like receptor 7	Mus musculus	77-81
26329008-7	2015	Notably, tin protoporphyrin IX (SnPP), an inhibitor of HO-1, also attenuated TLR7-induced transcription of the TNF-alpha and IL-6 genes, suggesting that the effect of quercetin is mediated by HO-1.	Quercetin	167-176	tumor necrosis factor	Mus musculus	111-120
26329008-7	2015	Notably, tin protoporphyrin IX (SnPP), an inhibitor of HO-1, also attenuated TLR7-induced transcription of the TNF-alpha and IL-6 genes, suggesting that the effect of quercetin is mediated by HO-1.	Quercetin	167-176	interleukin 6	Mus musculus	125-129
25588463-0	2015	Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1alpha pathway.	Quercetin	0-9	PPARG coactivator 1 alpha	Rattus norvegicus	127-137
25588463-10	2015	Furthermore, quercetin regulated the expression of sirtuin 1(Sirt1), PGC-1alpha, and the proteins related with mitochondrial biogenesis and dynamics.	Quercetin	13-22	sirtuin 1	Rattus norvegicus	51-60
26146123-11	2015	Quercetin derivatives have revealed antidepressant potential via elevating pro-opiomelanocortin and neuroprotective properties, as well as reduction of proinflammatory cytokines.	Quercetin	0-9	proopiomelanocortin	Homo sapiens	75-95
25588463-10	2015	Furthermore, quercetin regulated the expression of sirtuin 1(Sirt1), PGC-1alpha, and the proteins related with mitochondrial biogenesis and dynamics.	Quercetin	13-22	sirtuin 1	Rattus norvegicus	61-66
25588463-10	2015	Furthermore, quercetin regulated the expression of sirtuin 1(Sirt1), PGC-1alpha, and the proteins related with mitochondrial biogenesis and dynamics.	Quercetin	13-22	PPARG coactivator 1 alpha	Rattus norvegicus	69-79
25588463-11	2015	Moreover, quercetin increased expression of fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF), showing the PGC-1alpha/FNDC5/BNDF pathways might be involved in neuronal adaptation.	Quercetin	10-19	fibronectin type III domain containing 5	Rattus norvegicus	44-92
25588463-11	2015	Moreover, quercetin increased expression of fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF), showing the PGC-1alpha/FNDC5/BNDF pathways might be involved in neuronal adaptation.	Quercetin	10-19	fibronectin type III domain containing 5	Rattus norvegicus	94-99
25588463-11	2015	Moreover, quercetin increased expression of fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF), showing the PGC-1alpha/FNDC5/BNDF pathways might be involved in neuronal adaptation.	Quercetin	10-19	brain-derived neurotrophic factor	Rattus norvegicus	105-138
25588463-11	2015	Moreover, quercetin increased expression of fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF), showing the PGC-1alpha/FNDC5/BNDF pathways might be involved in neuronal adaptation.	Quercetin	10-19	brain-derived neurotrophic factor	Rattus norvegicus	140-144
25588463-11	2015	Moreover, quercetin increased expression of fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF), showing the PGC-1alpha/FNDC5/BNDF pathways might be involved in neuronal adaptation.	Quercetin	10-19	PPARG coactivator 1 alpha	Rattus norvegicus	159-169
25588463-11	2015	Moreover, quercetin increased expression of fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF), showing the PGC-1alpha/FNDC5/BNDF pathways might be involved in neuronal adaptation.	Quercetin	10-19	fibronectin type III domain containing 5	Rattus norvegicus	170-175
25460361-7	2014	Quercetin significantly restored the decrease in Kv currents, the upregulation of 5-HT2A receptors and reduced the Akt and S6 phosphorylation.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	115-118
26281317-2	2015	In this study, the comparative effect of pioglitazone, quercetin, and hydroxy citric acid on VEGF mRNA in experimentally induced NASH was investigated.	Quercetin	55-64	vascular endothelial growth factor A	Rattus norvegicus	93-97
26281317-6	2015	A very mild increase in VEGF mRNA expression was observed in the rats treated with quercetin.	Quercetin	83-92	vascular endothelial growth factor A	Rattus norvegicus	24-28
25211642-0	2014	Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity.	Quercetin	43-52	BCL2 apoptosis regulator	Homo sapiens	18-23
25211642-4	2014	It may be concluded that, quercetin binds directly to the BH3 domain of Bcl-2 and Bcl-xL proteins, thereby inhibiting their activity and promoting cancer cell apoptosis.	Quercetin	26-35	BCL2 apoptosis regulator	Homo sapiens	72-77
25211642-4	2014	It may be concluded that, quercetin binds directly to the BH3 domain of Bcl-2 and Bcl-xL proteins, thereby inhibiting their activity and promoting cancer cell apoptosis.	Quercetin	26-35	BCL2 like 1	Homo sapiens	82-88
25446924-9	2014	In conclusion, quercetin, luteolin and EGCG inhibited ER stress-associated TXNIP and NLRP3 inflammasome activation, and thereby protected endothelial cells from inflammatory and apoptotic damage.	Quercetin	15-24	thioredoxin interacting protein	Homo sapiens	75-80
25446924-9	2014	In conclusion, quercetin, luteolin and EGCG inhibited ER stress-associated TXNIP and NLRP3 inflammasome activation, and thereby protected endothelial cells from inflammatory and apoptotic damage.	Quercetin	15-24	NLR family pyrin domain containing 3	Homo sapiens	85-90
25498599-6	2014	RESULTS: The quality assessment methods and simultaneous docking studies on interaction of quercetin (as the most studied flavonoids) with BSA and Human serum albumin (HAS), confirm the accuracy of simulation and the second stage of docking results which were in close agreement with experimental observations, suggest that the potential residues in flavonoids binding sites (which were place neighbor of tryptophan 212 within 5A) cannot be considered as one of glycation sites.	Quercetin	91-100	albumin	Homo sapiens	153-166
25493635-5	2014	Among the isolated compounds, 5-hydroxy-7-methoxyflavone (5), quercetin (6), and (2S)-7-hydroxyflavanone (10) exhibited potent inhibition of fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 1.77 +- 0.70, 3.82 +- 0.46, and 4.92 +- 1.71 muM, respectively.	Quercetin	62-71	formyl peptide receptor 1	Homo sapiens	141-145
25493635-5	2014	Among the isolated compounds, 5-hydroxy-7-methoxyflavone (5), quercetin (6), and (2S)-7-hydroxyflavanone (10) exhibited potent inhibition of fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 1.77 +- 0.70, 3.82 +- 0.46, and 4.92 +- 1.71 muM, respectively.	Quercetin	62-71	latexin	Homo sapiens	269-272
26281317-8	2015	CONCLUSION: Quercetin exhibited an effective inhibition of VEGF mRNA expression, while a lower inhibition of the VEGF mRNA level was observed in the hydroxy citric acid- and the pioglitazone-treated rats.	Quercetin	12-21	vascular endothelial growth factor A	Rattus norvegicus	59-63
25446924-0	2014	Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells.	Quercetin	0-9	thioredoxin interacting protein	Homo sapiens	59-64
25446924-0	2014	Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells.	Quercetin	0-9	NLR family pyrin domain containing 3	Homo sapiens	69-74
25446924-0	2014	Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells.	Quercetin	0-9	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	130-134
25446924-5	2014	Quercetin, luteolin and EGCG reduced reactive oxygen species production and inhibited TXNIP and NLRP3 inflammasome activation, lead to the downregulation of IL-1beta expression.	Quercetin	0-9	thioredoxin interacting protein	Homo sapiens	86-91
25446924-5	2014	Quercetin, luteolin and EGCG reduced reactive oxygen species production and inhibited TXNIP and NLRP3 inflammasome activation, lead to the downregulation of IL-1beta expression.	Quercetin	0-9	NLR family pyrin domain containing 3	Homo sapiens	96-101
25446924-5	2014	Quercetin, luteolin and EGCG reduced reactive oxygen species production and inhibited TXNIP and NLRP3 inflammasome activation, lead to the downregulation of IL-1beta expression.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	157-165
25293876-1	2014	This study proposes to investigate quercetin antitumor efficacy in vitro and in vivo, using the P39 cell line as a model.	Quercetin	35-44	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	96-99
24266675-10	2014	Renal CAT levels were increased by cisplatin and cisplatin plus quercetin groups that is reversed by administration of quercetin before cisplatin.	Quercetin	64-73	catalase	Rattus norvegicus	6-9
24266675-10	2014	Renal CAT levels were increased by cisplatin and cisplatin plus quercetin groups that is reversed by administration of quercetin before cisplatin.	Quercetin	119-128	catalase	Rattus norvegicus	6-9
25293876-3	2014	Quercetin caused pronounced apoptosis in P39 leukemia cells, followed by Bcl-2, Bcl-xL, Mcl-1 downregulation, Bax upregulation, and mitochondrial translocation, triggering cytochrome c release and caspases activation.	Quercetin	0-9	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	41-44
25293876-3	2014	Quercetin caused pronounced apoptosis in P39 leukemia cells, followed by Bcl-2, Bcl-xL, Mcl-1 downregulation, Bax upregulation, and mitochondrial translocation, triggering cytochrome c release and caspases activation.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	73-78
25293876-3	2014	Quercetin caused pronounced apoptosis in P39 leukemia cells, followed by Bcl-2, Bcl-xL, Mcl-1 downregulation, Bax upregulation, and mitochondrial translocation, triggering cytochrome c release and caspases activation.	Quercetin	0-9	BCL2 like 1	Homo sapiens	80-86
25293876-3	2014	Quercetin caused pronounced apoptosis in P39 leukemia cells, followed by Bcl-2, Bcl-xL, Mcl-1 downregulation, Bax upregulation, and mitochondrial translocation, triggering cytochrome c release and caspases activation.	Quercetin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	88-93
25293876-3	2014	Quercetin caused pronounced apoptosis in P39 leukemia cells, followed by Bcl-2, Bcl-xL, Mcl-1 downregulation, Bax upregulation, and mitochondrial translocation, triggering cytochrome c release and caspases activation.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	110-113
25293876-3	2014	Quercetin caused pronounced apoptosis in P39 leukemia cells, followed by Bcl-2, Bcl-xL, Mcl-1 downregulation, Bax upregulation, and mitochondrial translocation, triggering cytochrome c release and caspases activation.	Quercetin	0-9	cytochrome c, somatic	Homo sapiens	172-184
25293876-4	2014	Quercetin also induced the expression of FasL protein.	Quercetin	0-9	Fas ligand	Homo sapiens	41-45
25293876-6	2014	Quercetin treatment resulted in an increased cell arrest in G1 phase of the cell cycle, with pronounced decrease in CDK2, CDK6, cyclin D, cyclin E, and cyclin A proteins, decreased Rb phosphorylation and increased p21 and p27 expression.	Quercetin	0-9	cyclin dependent kinase 2	Homo sapiens	116-120
25293876-6	2014	Quercetin treatment resulted in an increased cell arrest in G1 phase of the cell cycle, with pronounced decrease in CDK2, CDK6, cyclin D, cyclin E, and cyclin A proteins, decreased Rb phosphorylation and increased p21 and p27 expression.	Quercetin	0-9	cyclin dependent kinase 6	Homo sapiens	122-126
25293876-6	2014	Quercetin treatment resulted in an increased cell arrest in G1 phase of the cell cycle, with pronounced decrease in CDK2, CDK6, cyclin D, cyclin E, and cyclin A proteins, decreased Rb phosphorylation and increased p21 and p27 expression.	Quercetin	0-9	cyclin A2	Homo sapiens	152-160
25293876-6	2014	Quercetin treatment resulted in an increased cell arrest in G1 phase of the cell cycle, with pronounced decrease in CDK2, CDK6, cyclin D, cyclin E, and cyclin A proteins, decreased Rb phosphorylation and increased p21 and p27 expression.	Quercetin	0-9	H3 histone pseudogene 16	Homo sapiens	214-217
25311813-1	2014	The study aimed to assess biophysical changes that take place in the peripheral blood mononuclear cell (PBMC) membranes when exposed in vitro to 10 muM quercetin or epigallocatechin gallate (EGCG) for 24 and 48 h. PBMCs isolated from hypercholesterolemia patients were compared to those from normocholesterolemia subjects.	Quercetin	152-161	latexin	Homo sapiens	148-151
25293876-6	2014	Quercetin treatment resulted in an increased cell arrest in G1 phase of the cell cycle, with pronounced decrease in CDK2, CDK6, cyclin D, cyclin E, and cyclin A proteins, decreased Rb phosphorylation and increased p21 and p27 expression.	Quercetin	0-9	dynactin subunit 6	Homo sapiens	222-225
25293876-7	2014	Quercetin induced autophagosome formation in the P39 cell line.	Quercetin	0-9	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	49-52
25293876-9	2014	P39 cell treatment with a combination of quercetin and selective inhibitors of ERK1/2 and/or JNK (PD184352 or SP600125, respectively), significantly decreased cells in G1 phase, this treatment, however, did not change the apoptotic cell number.	Quercetin	41-50	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	0-3
25293876-9	2014	P39 cell treatment with a combination of quercetin and selective inhibitors of ERK1/2 and/or JNK (PD184352 or SP600125, respectively), significantly decreased cells in G1 phase, this treatment, however, did not change the apoptotic cell number.	Quercetin	41-50	mitogen-activated protein kinase 3	Homo sapiens	79-85
25293876-10	2014	Furthermore, in vivo administration of quercetin significantly reduced tumor volume in P39 xenografts and confirmed in vitro results regarding apoptosis, autophagy, and cell-cycle arrest.	Quercetin	39-48	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	87-90
24702479-3	2014	We previously showed on beta-cells that quercetin (Q), but not resveratrol (R) or N-acetyl cysteine (NAC), amplified glucose-induced insulin secretion in a calcium- and ERK1/2-dependent manner.	Quercetin	40-49	mitogen activated protein kinase 3	Rattus norvegicus	169-175
24702479-4	2014	Quercetin, but not resveratrol or NAC, also protected beta-cell function and hyperamplified ERK1/2 phosphorylation in oxidative stress conditions.	Quercetin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	92-98
24702479-5	2014	As quercetin may interfere with other stress-activated protein kinases (JNK and p38 MAPK), we further explored MAPK cross talks and their relationships with the mechanism of the protective effect of quercetin against oxidative stress.	Quercetin	3-12	mitogen-activated protein kinase 8	Rattus norvegicus	72-75
25204422-0	2014	Reduced glutathione increases quercetin stimulatory effects on HDL- or apoA1-mediated cholesterol efflux from J774A.1 macrophages.	Quercetin	30-39	apolipoprotein A1	Homo sapiens	71-76
25204422-3	2014	Similarly, apoA1-mediated cholesterol efflux was increased by 11% or 22% in quercetin or quercetin + GSH-treated cells, respectively, versus control cells.	Quercetin	76-85	apolipoprotein A1	Homo sapiens	11-16
25204422-3	2014	Similarly, apoA1-mediated cholesterol efflux was increased by 11% or 22% in quercetin or quercetin + GSH-treated cells, respectively, versus control cells.	Quercetin	89-98	apolipoprotein A1	Homo sapiens	11-16
25204422-8	2014	In contrast, mRNA levels for ABCA1 and peroxisome proliferator-activated receptor alpha (PPARalpha) were both significantly increased by 89% and 93%, respectively, in quercetin + GSH-treated cells versus control cells.	Quercetin	167-176	ATP binding cassette subfamily A member 1	Homo sapiens	29-34
25204422-8	2014	In contrast, mRNA levels for ABCA1 and peroxisome proliferator-activated receptor alpha (PPARalpha) were both significantly increased by 89% and 93%, respectively, in quercetin + GSH-treated cells versus control cells.	Quercetin	167-176	peroxisome proliferator activated receptor alpha	Homo sapiens	39-87
25204422-8	2014	In contrast, mRNA levels for ABCA1 and peroxisome proliferator-activated receptor alpha (PPARalpha) were both significantly increased by 89% and 93%, respectively, in quercetin + GSH-treated cells versus control cells.	Quercetin	167-176	peroxisome proliferator activated receptor alpha	Homo sapiens	89-98
25204422-9	2014	Quercetin alone increased the mRNA levels for ABCA1 or PPARalpha by 42% or 77%, respectively, whereas GSH alone increased it by 22% or 28%, respectively.	Quercetin	0-9	ATP binding cassette subfamily A member 1	Homo sapiens	46-51
25204422-9	2014	Quercetin alone increased the mRNA levels for ABCA1 or PPARalpha by 42% or 77%, respectively, whereas GSH alone increased it by 22% or 28%, respectively.	Quercetin	0-9	peroxisome proliferator activated receptor alpha	Homo sapiens	55-64
24702479-5	2014	As quercetin may interfere with other stress-activated protein kinases (JNK and p38 MAPK), we further explored MAPK cross talks and their relationships with the mechanism of the protective effect of quercetin against oxidative stress.	Quercetin	3-12	mitogen activated protein kinase 14	Rattus norvegicus	80-83
25204422-11	2014	We thus conclude that the stimulatory effects of quercetin + GSH on apoA1- or HDL-mediated macrophage cholesterol efflux are related to the ability of GSH to preserve quercetin in its reduced form.	Quercetin	49-58	apolipoprotein A1	Homo sapiens	68-73
24702479-5	2014	As quercetin may interfere with other stress-activated protein kinases (JNK and p38 MAPK), we further explored MAPK cross talks and their relationships with the mechanism of the protective effect of quercetin against oxidative stress.	Quercetin	3-12	mitogen activated protein kinase 3	Rattus norvegicus	84-88
25204422-11	2014	We thus conclude that the stimulatory effects of quercetin + GSH on apoA1- or HDL-mediated macrophage cholesterol efflux are related to the ability of GSH to preserve quercetin in its reduced form.	Quercetin	167-176	apolipoprotein A1	Homo sapiens	68-73
24702479-8	2014	The protecting effect of quercetin appears due to ERK1/2 hyperactivation, possibly induced by L-type calcium channel opening as we recently showed.	Quercetin	25-34	mitogen activated protein kinase 3	Rattus norvegicus	50-56
25471833-2	2014	Quercetin decreased CCl4-increased serum activities of alanine and aspartate aminotransferases (ALT/AST) when orally taken 30 min after CCl4 intoxication.	Quercetin	0-9	chemokine (C-C motif) ligand 4	Mus musculus	20-24
24912504-5	2014	Quercetin markedly rescued lethality, improved survival time, and inhibited serum necrosis factor alpha, interleukin 1beta, and interleukin 6, and nitric oxide (NO), and increased IL-10 secretion.	Quercetin	0-9	interleukin 1 beta	Mus musculus	105-122
24912504-5	2014	Quercetin markedly rescued lethality, improved survival time, and inhibited serum necrosis factor alpha, interleukin 1beta, and interleukin 6, and nitric oxide (NO), and increased IL-10 secretion.	Quercetin	0-9	interleukin 6	Mus musculus	128-141
24912504-5	2014	Quercetin markedly rescued lethality, improved survival time, and inhibited serum necrosis factor alpha, interleukin 1beta, and interleukin 6, and nitric oxide (NO), and increased IL-10 secretion.	Quercetin	0-9	interleukin 10	Mus musculus	180-185
24912504-6	2014	Moreover, quercetin decreased lung pathological changes, myeloperoxidase activity, and malondialdehyde levels.	Quercetin	10-19	myeloperoxidase	Mus musculus	57-72
24912504-8	2014	Additionally, quercetin significantly reduced COX-2, HMGB1, iNOS expression, and NF-kappaB p65 phosphorylation.	Quercetin	14-23	cytochrome c oxidase II, mitochondrial	Mus musculus	46-51
24912504-8	2014	Additionally, quercetin significantly reduced COX-2, HMGB1, iNOS expression, and NF-kappaB p65 phosphorylation.	Quercetin	14-23	high mobility group box 1	Mus musculus	53-58
24912504-8	2014	Additionally, quercetin significantly reduced COX-2, HMGB1, iNOS expression, and NF-kappaB p65 phosphorylation.	Quercetin	14-23	nitric oxide synthase 2, inducible	Mus musculus	60-64
25471833-1	2014	This study observes the therapeutic detoxification of quercetin, a well-known flavonoid, against carbon tetrachloride (CCl4) induced acute liver injury in vivo and explores its mechanism.	Quercetin	54-63	chemokine (C-C motif) ligand 4	Mus musculus	119-123
25471833-2	2014	Quercetin decreased CCl4-increased serum activities of alanine and aspartate aminotransferases (ALT/AST) when orally taken 30 min after CCl4 intoxication.	Quercetin	0-9	glutamic pyruvic transaminase, soluble	Mus musculus	96-99
25471833-2	2014	Quercetin decreased CCl4-increased serum activities of alanine and aspartate aminotransferases (ALT/AST) when orally taken 30 min after CCl4 intoxication.	Quercetin	0-9	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	100-103
25471833-2	2014	Quercetin decreased CCl4-increased serum activities of alanine and aspartate aminotransferases (ALT/AST) when orally taken 30 min after CCl4 intoxication.	Quercetin	0-9	chemokine (C-C motif) ligand 4	Mus musculus	136-140
24801949-0	2014	Investigation of the interaction between quercetin and human serum albumin by multiple spectra, electrochemical impedance spectra and molecular modeling.	Quercetin	41-50	albumin	Homo sapiens	61-74
25471833-3	2014	The results of a histological evaluation further evidenced the ability of quercetin to protect against CCl4-induced liver injury.	Quercetin	74-83	chemokine (C-C motif) ligand 4	Mus musculus	103-107
25471833-4	2014	Quercetin decreased the CCl4-increased malondialdehyde (MDA) and reduced the glutathione (GSH) amounts in the liver.	Quercetin	0-9	chemokine (C-C motif) ligand 4	Mus musculus	24-28
25471833-7	2014	Real-time polymerase chain reaction (PCR) results demonstrated that quercetin reversed the decreased mRNA expression of all those genes induced by CCl4.	Quercetin	68-77	chemokine (C-C motif) ligand 4	Mus musculus	147-151
25471833-8	2014	In conclusion, our results demonstrate that quercetin ameliorates CCl4-induced acute liver injury in vivo via alleviating oxidative stress injuries when orally taken after CCl4 intoxication.	Quercetin	44-53	chemokine (C-C motif) ligand 4	Mus musculus	66-70
25471833-8	2014	In conclusion, our results demonstrate that quercetin ameliorates CCl4-induced acute liver injury in vivo via alleviating oxidative stress injuries when orally taken after CCl4 intoxication.	Quercetin	44-53	chemokine (C-C motif) ligand 4	Mus musculus	172-176
25323558-7	2014	Quercetin also restored the protein expression of Osterix in MC3T3-E1 cells suppressed by LPS.	Quercetin	0-9	Sp7 transcription factor 7	Mus musculus	50-57
25084985-0	2014	ELF-MF attenuates quercetin-induced apoptosis in K562 cells through modulating the expression of Bcl-2 family proteins.	Quercetin	18-27	BCL2 apoptosis regulator	Homo sapiens	97-102
25084985-3	2014	On the contrary, in quercetin-treated cells, exposure to ELF-MF significantly reduced the percentage of apoptotic cells and the caspase-3 activity and modified the cell cycle profile especially after 48 h of exposure.	Quercetin	20-29	caspase 3	Homo sapiens	128-137
25084985-4	2014	In addition, the simultaneous treatments for 24 h with quercetin plus ELF-MF increased Bcl-2 protein expression and prevented quercetin-induced downregulation of Mcl-1 and Bcl-xL.	Quercetin	55-64	BCL2 apoptosis regulator	Homo sapiens	87-92
25084985-4	2014	In addition, the simultaneous treatments for 24 h with quercetin plus ELF-MF increased Bcl-2 protein expression and prevented quercetin-induced downregulation of Mcl-1 and Bcl-xL.	Quercetin	55-64	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	162-167
25084985-4	2014	In addition, the simultaneous treatments for 24 h with quercetin plus ELF-MF increased Bcl-2 protein expression and prevented quercetin-induced downregulation of Mcl-1 and Bcl-xL.	Quercetin	55-64	BCL2 like 1	Homo sapiens	172-178
25084985-4	2014	In addition, the simultaneous treatments for 24 h with quercetin plus ELF-MF increased Bcl-2 protein expression and prevented quercetin-induced downregulation of Mcl-1 and Bcl-xL.	Quercetin	126-135	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	162-167
25084985-4	2014	In addition, the simultaneous treatments for 24 h with quercetin plus ELF-MF increased Bcl-2 protein expression and prevented quercetin-induced downregulation of Mcl-1 and Bcl-xL.	Quercetin	126-135	BCL2 like 1	Homo sapiens	172-178
25543474-6	2014	Quercetin could activate caspase-3 and promote leukemic cell apoptosis.	Quercetin	0-9	caspase 3	Mus musculus	25-34
24118142-9	2014	Quercetin supplementation increased SIRT1 expression, but when quercetin is supplemented during exercise, this effect is abolished (P &lt; 0.001).	Quercetin	0-9	sirtuin 1	Rattus norvegicus	36-41
24118142-10	2014	The combination of exercise and quercetin supplementation caused lower (P &lt; 0.05) mtDNA content and CS activity when compared with exercise alone.	Quercetin	32-41	citrate synthase	Rattus norvegicus	103-105
25281414-12	2014	Rutin had no effect on splenocytes or murine T cells in vitro, while its aglycone, quercetin, exhibited a concentration dependent inhibition of proinflammatory cytokines, including IFNgamma.	Quercetin	83-92	interferon gamma	Mus musculus	181-189
25196644-5	2014	Both caffeic acid and quercetin were potent competitive inhibitors of CYP1A2 (Ki = 1.16 and 0.93 muM, respectively) and CYP2C9 (Ki = 0.95 and 1.67 muM, respectively).	Quercetin	22-31	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
25196644-5	2014	Both caffeic acid and quercetin were potent competitive inhibitors of CYP1A2 (Ki = 1.16 and 0.93 muM, respectively) and CYP2C9 (Ki = 0.95 and 1.67 muM, respectively).	Quercetin	22-31	latexin	Homo sapiens	97-100
25196644-5	2014	Both caffeic acid and quercetin were potent competitive inhibitors of CYP1A2 (Ki = 1.16 and 0.93 muM, respectively) and CYP2C9 (Ki = 0.95 and 1.67 muM, respectively).	Quercetin	22-31	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	120-126
25196644-5	2014	Both caffeic acid and quercetin were potent competitive inhibitors of CYP1A2 (Ki = 1.16 and 0.93 muM, respectively) and CYP2C9 (Ki = 0.95 and 1.67 muM, respectively).	Quercetin	22-31	latexin	Homo sapiens	147-150
25196644-7	2014	Quercetin was a potent competitive inhibitor of CYP 2C19 and CYP3A4 (Ki = 1.74 and 4.12 muM, respectively) and a moderate competitive inhibitor of CYP2D6 (Ki = 18.72 muM).	Quercetin	0-9	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	48-56
25196644-7	2014	Quercetin was a potent competitive inhibitor of CYP 2C19 and CYP3A4 (Ki = 1.74 and 4.12 muM, respectively) and a moderate competitive inhibitor of CYP2D6 (Ki = 18.72 muM).	Quercetin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	61-67
25196644-7	2014	Quercetin was a potent competitive inhibitor of CYP 2C19 and CYP3A4 (Ki = 1.74 and 4.12 muM, respectively) and a moderate competitive inhibitor of CYP2D6 (Ki = 18.72 muM).	Quercetin	0-9	latexin	Homo sapiens	88-91
25196644-7	2014	Quercetin was a potent competitive inhibitor of CYP 2C19 and CYP3A4 (Ki = 1.74 and 4.12 muM, respectively) and a moderate competitive inhibitor of CYP2D6 (Ki = 18.72 muM).	Quercetin	0-9	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	147-153
25196644-7	2014	Quercetin was a potent competitive inhibitor of CYP 2C19 and CYP3A4 (Ki = 1.74 and 4.12 muM, respectively) and a moderate competitive inhibitor of CYP2D6 (Ki = 18.72 muM).	Quercetin	0-9	latexin	Homo sapiens	166-169
25543474-7	2014	Meanwhile, quercetin could down-regulate the expression of BCL-2 and NF-kappaB gene, and up-regulate the expression of BAX gene.	Quercetin	11-20	B cell leukemia/lymphoma 2	Mus musculus	59-64
25543474-7	2014	Meanwhile, quercetin could down-regulate the expression of BCL-2 and NF-kappaB gene, and up-regulate the expression of BAX gene.	Quercetin	11-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
25543474-7	2014	Meanwhile, quercetin could down-regulate the expression of BCL-2 and NF-kappaB gene, and up-regulate the expression of BAX gene.	Quercetin	11-20	BCL2-associated X protein	Mus musculus	119-122
25413579-4	2014	Here, we investigated whether the intratracheal administration of quercetin could suppress lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice as well as the involvement of HO-1 in quercetin"s suppressive effects.	Quercetin	194-203	heme oxygenase 1	Mus musculus	186-190
25413579-9	2014	Moreover, quercetin decreased MMP-9 activity and the production of pro-inflammatory cytokines in BALF cells activated by LPS in advance.	Quercetin	10-19	matrix metallopeptidase 9	Mus musculus	30-35
25413579-10	2014	We determined the expression of quercetin-induced HO-1 in mouse lung, e.g., alveolar macrophages (AMs), alveolar and bronchial epithelial cells.	Quercetin	32-41	heme oxygenase 1	Mus musculus	50-54
25108658-10	2014	The antifibrotic effect of quercetin was accompanied by reductions in alpha-smooth muscle actin-positive matrix-producing cells and Smad 2/3 activity critical to the fibrogenic potential of TGF-beta1.	Quercetin	27-36	SMAD family member 2	Rattus norvegicus	132-140
24902540-0	2014	Quercetin potentiates the antitumor activity of rituximab in diffuse large B-cell lymphoma by inhibiting STAT3 pathway.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	105-110
24976071-0	2014	Biological evaluation and SAR analysis of O-methylated analogs of quercetin as inhibitors of cancer cell proliferation.	Quercetin	66-75	sarcosine dehydrogenase	Homo sapiens	26-29
25375374-5	2014	Natural polyphenolic compounds that are present in our diet, such as rottlerin, genistein, quercetin, curcumin, and resveratrol, can trigger type II PCD via various mechanisms through the canonical (Beclin-1 dependent) and non-canonical (Beclin-1 independent) routes of autophagy.	Quercetin	91-100	beclin 1	Homo sapiens	199-207
25375374-5	2014	Natural polyphenolic compounds that are present in our diet, such as rottlerin, genistein, quercetin, curcumin, and resveratrol, can trigger type II PCD via various mechanisms through the canonical (Beclin-1 dependent) and non-canonical (Beclin-1 independent) routes of autophagy.	Quercetin	91-100	beclin 1	Homo sapiens	238-246
24902540-4	2014	Moreover, we found Quercetin exerted inhibitory activity against STAT3 pathway and downregulated the expression of survival genes.	Quercetin	19-28	signal transducer and activator of transcription 3	Homo sapiens	65-70
25087994-0	2014	Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	76-104
25087994-4	2014	Here, we investigated the role of AMP-activated protein kinase (AMPK)-regulated autophagy in renal protection by quercetin.	Quercetin	113-122	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	34-62
25087994-4	2014	Here, we investigated the role of AMP-activated protein kinase (AMPK)-regulated autophagy in renal protection by quercetin.	Quercetin	113-122	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	64-68
25087994-9	2014	In cultured renal tubular cell I/R model, quercetin decreased the cell injury, up-regulated the AMPK phosphorylation, down-regulated the mammalian target of rapamycin (mTOR) phosphorylation and activated autophagy during I/R.	Quercetin	42-51	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	96-100
25087994-9	2014	In cultured renal tubular cell I/R model, quercetin decreased the cell injury, up-regulated the AMPK phosphorylation, down-regulated the mammalian target of rapamycin (mTOR) phosphorylation and activated autophagy during I/R.	Quercetin	42-51	mechanistic target of rapamycin kinase	Homo sapiens	137-166
25087994-9	2014	In cultured renal tubular cell I/R model, quercetin decreased the cell injury, up-regulated the AMPK phosphorylation, down-regulated the mammalian target of rapamycin (mTOR) phosphorylation and activated autophagy during I/R.	Quercetin	42-51	mechanistic target of rapamycin kinase	Homo sapiens	168-172
25087994-10	2014	Knockdown of AMPK by shRNA transfection decreased the quercetin-induced autophagy but did not affect the mTOR phosphorylation.	Quercetin	54-63	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	13-17
25087994-12	2014	Quercetin also increased AMPK phosphorylation, inhibited the mTOR phosphorylation and activated autophagy in the kidneys of I/R mice.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	25-29
25087994-12	2014	Quercetin also increased AMPK phosphorylation, inhibited the mTOR phosphorylation and activated autophagy in the kidneys of I/R mice.	Quercetin	0-9	mechanistic target of rapamycin kinase	Mus musculus	61-65
25087994-13	2014	These results suggest that quercetin activates an AMPK-regulated autophagy signaling pathway, which offers a protective effect in renal I/R injury.	Quercetin	27-36	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	50-54
25150162-4	2014	Quercetin, a plant flavonoid, prevented EGF-induced invasion and migration of PC-3 cells.	Quercetin	0-9	epidermal growth factor	Homo sapiens	40-43
25150162-6	2014	Quercetin prevented EGF-induced expression of N-cadherin and vimentin and increased the expression of E-cadherin in PC-3 cells, therefore preventing EGF-induced EMT.	Quercetin	0-9	epidermal growth factor	Homo sapiens	20-23
25150162-6	2014	Quercetin prevented EGF-induced expression of N-cadherin and vimentin and increased the expression of E-cadherin in PC-3 cells, therefore preventing EGF-induced EMT.	Quercetin	0-9	cadherin 2	Homo sapiens	46-56
25150162-6	2014	Quercetin prevented EGF-induced expression of N-cadherin and vimentin and increased the expression of E-cadherin in PC-3 cells, therefore preventing EGF-induced EMT.	Quercetin	0-9	vimentin	Homo sapiens	61-69
25150162-6	2014	Quercetin prevented EGF-induced expression of N-cadherin and vimentin and increased the expression of E-cadherin in PC-3 cells, therefore preventing EGF-induced EMT.	Quercetin	0-9	cadherin 1	Homo sapiens	102-112
25150162-6	2014	Quercetin prevented EGF-induced expression of N-cadherin and vimentin and increased the expression of E-cadherin in PC-3 cells, therefore preventing EGF-induced EMT.	Quercetin	0-9	epidermal growth factor	Homo sapiens	149-152
25150162-7	2014	EGF-induced cell adhesion proteins, intercellular adhesion molecule and vascular cell adhesion molecule were significantly decreased by quercetin treatment.	Quercetin	136-145	epidermal growth factor	Homo sapiens	0-3
25150162-8	2014	Furthermore, mRNA and protein expressions of Snail, Slug and Twist showed that quercetin significantly decreased EGF-induced expressions of Snail, Slug and Twist.	Quercetin	79-88	snail family transcriptional repressor 1	Homo sapiens	45-50
25150162-8	2014	Furthermore, mRNA and protein expressions of Snail, Slug and Twist showed that quercetin significantly decreased EGF-induced expressions of Snail, Slug and Twist.	Quercetin	79-88	snail family transcriptional repressor 2	Homo sapiens	52-56
25150162-8	2014	Furthermore, mRNA and protein expressions of Snail, Slug and Twist showed that quercetin significantly decreased EGF-induced expressions of Snail, Slug and Twist.	Quercetin	79-88	epidermal growth factor	Homo sapiens	113-116
25108658-9	2014	Quercetin alleviated BDL-induced transforming growth factor beta-1 (TGF-beta1), interleukin-1 beta, connective tissue growth factor and collagen expression.	Quercetin	0-9	transforming growth factor, beta 1	Rattus norvegicus	68-77
25108658-9	2014	Quercetin alleviated BDL-induced transforming growth factor beta-1 (TGF-beta1), interleukin-1 beta, connective tissue growth factor and collagen expression.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	80-98
25150162-8	2014	Furthermore, mRNA and protein expressions of Snail, Slug and Twist showed that quercetin significantly decreased EGF-induced expressions of Snail, Slug and Twist.	Quercetin	79-88	snail family transcriptional repressor 1	Homo sapiens	140-145
25108658-10	2014	The antifibrotic effect of quercetin was accompanied by reductions in alpha-smooth muscle actin-positive matrix-producing cells and Smad 2/3 activity critical to the fibrogenic potential of TGF-beta1.	Quercetin	27-36	transforming growth factor, beta 1	Rattus norvegicus	190-199
25150162-8	2014	Furthermore, mRNA and protein expressions of Snail, Slug and Twist showed that quercetin significantly decreased EGF-induced expressions of Snail, Slug and Twist.	Quercetin	79-88	snail family transcriptional repressor 2	Homo sapiens	147-151
25150162-9	2014	The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells.	Quercetin	177-186	epidermal growth factor receptor	Homo sapiens	27-59
25150162-0	2014	Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway.	Quercetin	0-9	epidermal growth factor	Homo sapiens	19-22
25108658-9	2014	Quercetin alleviated BDL-induced transforming growth factor beta-1 (TGF-beta1), interleukin-1 beta, connective tissue growth factor and collagen expression.	Quercetin	0-9	cellular communication network factor 2	Rattus norvegicus	100-131
25150162-3	2014	The purpose of this study was to determine the effect of quercetin on EGF-induced EMT in prostate cancer (PC-3) cell line.	Quercetin	57-66	epidermal growth factor	Homo sapiens	70-73
25150162-9	2014	The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells.	Quercetin	177-186	epidermal growth factor receptor	Homo sapiens	61-65
25108658-12	2014	Further studies demonstrated an inhibitory effect of quercetin on MyD88 and TGF-beta-activated kinase-1 critical for linking toll-like receptor (TLR) and NF-kappaB.	Quercetin	53-62	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	66-71
25150162-9	2014	The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells.	Quercetin	177-186	AKT serine/threonine kinase 1	Homo sapiens	106-109
25150162-9	2014	The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells.	Quercetin	177-186	mitogen-activated protein kinase 1	Homo sapiens	110-156
25150162-9	2014	The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells.	Quercetin	177-186	epidermal growth factor	Homo sapiens	61-64
25150162-9	2014	The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells.	Quercetin	177-186	epidermal growth factor receptor	Homo sapiens	216-220
25150162-9	2014	The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells.	Quercetin	177-186	AKT serine/threonine kinase 1	Homo sapiens	226-229
25108658-14	2014	The beneficial effects of daily quercetin supplementation are associated with antioxidative and anti-inflammatory potential as well as down-regulation of NF-kappaB and TGF-beta/Smad signaling, probably via interference with TLR signaling.	Quercetin	32-41	transforming growth factor, beta 1	Rattus norvegicus	168-176
25150162-9	2014	The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells.	Quercetin	177-186	mitogen-activated protein kinase 3	Homo sapiens	230-236
25150162-9	2014	The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells.	Quercetin	177-186	snail family transcriptional repressor 1	Homo sapiens	291-296
25150162-0	2014	Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway.	Quercetin	0-9	epidermal growth factor receptor	Homo sapiens	125-129
25150162-9	2014	The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells.	Quercetin	177-186	snail family transcriptional repressor 2	Homo sapiens	298-302
25150162-0	2014	Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	135-138
24397597-4	2014	We found that quercetin inhibited the proliferation of MM cells in a dose- and time-dependent manner, accompanied by reduced IQGAP1 expression at mRNA and protein levels, and reduced extracellular signal-regulated kinase 1/2 (ERK1/2) activation.	Quercetin	14-23	IQ motif containing GTPase activating protein 1	Homo sapiens	125-131
24397597-0	2014	Quercetin suppresses the proliferation of multiple myeloma cells by down-regulating IQ motif-containing GTPase activating protein 1 expression and extracellular signal-regulated kinase activation.	Quercetin	0-9	IQ motif containing GTPase activating protein 1	Homo sapiens	84-131
24397597-4	2014	We found that quercetin inhibited the proliferation of MM cells in a dose- and time-dependent manner, accompanied by reduced IQGAP1 expression at mRNA and protein levels, and reduced extracellular signal-regulated kinase 1/2 (ERK1/2) activation.	Quercetin	14-23	mitogen-activated protein kinase 1	Homo sapiens	183-224
24397597-4	2014	We found that quercetin inhibited the proliferation of MM cells in a dose- and time-dependent manner, accompanied by reduced IQGAP1 expression at mRNA and protein levels, and reduced extracellular signal-regulated kinase 1/2 (ERK1/2) activation.	Quercetin	14-23	mitogen-activated protein kinase 3	Homo sapiens	226-232
24397597-5	2014	Furthermore, we found that quercetin inhibited the interaction between IQGAP1 and ERK1/2 in RPMI8226 cells.	Quercetin	27-36	IQ motif containing GTPase activating protein 1	Homo sapiens	71-77
24397597-5	2014	Furthermore, we found that quercetin inhibited the interaction between IQGAP1 and ERK1/2 in RPMI8226 cells.	Quercetin	27-36	mitogen-activated protein kinase 3	Homo sapiens	82-88
24397597-6	2014	In summary, our results suggest that quercetin suppresses the proliferation of MM cells by down-regulating IQGAP1 expression and ERK activation, and has potential as a novel agent to target oncogenic kinase cascades for MM therapy.	Quercetin	37-46	IQ motif containing GTPase activating protein 1	Homo sapiens	107-113
24397597-6	2014	In summary, our results suggest that quercetin suppresses the proliferation of MM cells by down-regulating IQGAP1 expression and ERK activation, and has potential as a novel agent to target oncogenic kinase cascades for MM therapy.	Quercetin	37-46	mitogen-activated protein kinase 1	Homo sapiens	129-132
25241911-3	2014	We have determined that the multidrug and toxic compound extrusion transporter-1 (MATE1) is a membrane transporter for flavonoids and has a high affinity for quercetin.	Quercetin	158-167	solute carrier family 47 member 1	Homo sapiens	28-80
25064450-5	2014	The treatment with quercetin 25 and 50 mg/kg prevented this increase in the ATP and ADP hydrolysis, while the treatment with quercetin 5, 25, and 50 mg/kg prevented the increase in the ADA activity.	Quercetin	125-134	adenosine deaminase	Rattus norvegicus	185-188
25064450-6	2014	AChE, BChE, and MPO activities ex vivo presented an increase in the Cd-exposed group when compared to the control group, and the treatment with quercetin 5, 25, and 50 mg/kg prevented this increase caused by Cd exposure.	Quercetin	144-153	butyrylcholinesterase	Rattus norvegicus	6-10
25064450-6	2014	AChE, BChE, and MPO activities ex vivo presented an increase in the Cd-exposed group when compared to the control group, and the treatment with quercetin 5, 25, and 50 mg/kg prevented this increase caused by Cd exposure.	Quercetin	144-153	myeloperoxidase	Rattus norvegicus	16-19
25064450-7	2014	The in vitro experiment showed that quercetin 5, 10, 25, or 50 microM decreased the ADA activity proportionally to the increase of the concentrations of quercetin when compared to the control group.	Quercetin	36-45	adenosine deaminase	Rattus norvegicus	84-87
25064450-7	2014	The in vitro experiment showed that quercetin 5, 10, 25, or 50 microM decreased the ADA activity proportionally to the increase of the concentrations of quercetin when compared to the control group.	Quercetin	153-162	adenosine deaminase	Rattus norvegicus	84-87
25064450-8	2014	Thus, we can suggest that the quercetin is able to modulate NTPDase, ADA, AChE, and MPO activities and contribute to maintain the levels of ATP, adenosine, and acetylcholine normal, respectively, exhibiting potent pro-inflammatory and anti-inflammatory actions.	Quercetin	30-39	adenosine deaminase	Rattus norvegicus	69-72
25064450-8	2014	Thus, we can suggest that the quercetin is able to modulate NTPDase, ADA, AChE, and MPO activities and contribute to maintain the levels of ATP, adenosine, and acetylcholine normal, respectively, exhibiting potent pro-inflammatory and anti-inflammatory actions.	Quercetin	30-39	myeloperoxidase	Rattus norvegicus	84-87
24837940-5	2014	Unsupervised principal component analysis of samples from 2012 indicated that a major difference between fresh material and dried material is the increased amount of quercetin, a known alpha-glucosidase inhibitor.	Quercetin	166-175	sucrase-isomaltase	Homo sapiens	185-202
25064450-0	2014	Protective effect of quercetin in ecto-enzymes, cholinesterases, and myeloperoxidase activities in the lymphocytes of rats exposed to cadmium.	Quercetin	21-30	myeloperoxidase	Rattus norvegicus	69-84
25004411-7	2014	EX-527, quercetin and three pseudopeptidic compounds were found to be the most potent SIRT6 inhibitors, exhibiting over 50% deacetylation inhibition.	Quercetin	8-17	sirtuin 6	Homo sapiens	86-91
25241911-3	2014	We have determined that the multidrug and toxic compound extrusion transporter-1 (MATE1) is a membrane transporter for flavonoids and has a high affinity for quercetin.	Quercetin	158-167	solute carrier family 47 member 1	Homo sapiens	82-87
25241911-4	2014	HEK293T cells overexpressing MATE1 exhibited increased intracellular quercetin accumulation.	Quercetin	69-78	solute carrier family 47 member 1	Homo sapiens	29-34
25241911-6	2014	HepG2 cells expressed MATE1 significantly, with the uptake quercetin of which was dramatically reduced with MATE1 inhibition.	Quercetin	59-68	solute carrier family 47 member 1	Homo sapiens	108-113
25241911-7	2014	On the basis of immunofluorescence analysis, MATE1 was highly expressed in peroxisomes and the endoplasmic reticulum (ER) as well as in plasma membranes in the liver and intestine, which suggests potential accumulation of quercetin in peroxisomes and the ER in these tissues.	Quercetin	222-231	solute carrier family 47 member 1	Homo sapiens	45-50
25241911-9	2014	The effects of quercetin on cellular lipid reduction and glucose uptake were exaggerated with MATE1 overexpression.	Quercetin	15-24	solute carrier family 47 member 1	Homo sapiens	94-99
25241911-10	2014	In conclusion, MATE1 is a membrane transporter for quercetin; its overexpression enhances the hypolipidemic activity of quercetin and cellular glucose transport.	Quercetin	51-60	solute carrier family 47 member 1	Homo sapiens	15-20
25241911-10	2014	In conclusion, MATE1 is a membrane transporter for quercetin; its overexpression enhances the hypolipidemic activity of quercetin and cellular glucose transport.	Quercetin	120-129	solute carrier family 47 member 1	Homo sapiens	15-20
25241911-11	2014	Considering the low bioavailability of quercetin, appropriate regulation of MATE1 expression may optimize cellular quercetin concentrations and promote health benefits.	Quercetin	39-48	solute carrier family 47 member 1	Homo sapiens	76-81
25241911-11	2014	Considering the low bioavailability of quercetin, appropriate regulation of MATE1 expression may optimize cellular quercetin concentrations and promote health benefits.	Quercetin	115-124	solute carrier family 47 member 1	Homo sapiens	76-81
24902966-0	2014	Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression.	Quercetin	0-9	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	62-67
24020584-1	2014	This study was conducted to investigate the effect of quercetin on carbon tetrachloride (CCl4 )-induced sperm damages, testicular apoptosis and oxidative stress in male rats.	Quercetin	54-63	C-C motif chemokine ligand 4	Rattus norvegicus	89-93
24020584-5	2014	However, administration of CCl4 together with quercetin provided statistically significant improvements in LPO level, abnormal sperm rate, the degree of histopathological lesions and testicular apoptotic cell index when compared to only CCl4 group.	Quercetin	46-55	C-C motif chemokine ligand 4	Rattus norvegicus	237-241
24020584-7	2014	In conclusion, quercetin has antiperoxidative effect, and its oral administration attenuates the CCl4 -induced some damages in male reproductive organs and cells by decreasing the LPO.	Quercetin	15-24	C-C motif chemokine ligand 4	Rattus norvegicus	97-101
25241191-0	2014	RETRACTED: Quercetin suppresses insulin receptor signaling through inhibition of the insulin ligand-receptor binding and therefore impairs cancer cell proliferation.	Quercetin	11-20	insulin	Homo sapiens	32-39
25241191-0	2014	RETRACTED: Quercetin suppresses insulin receptor signaling through inhibition of the insulin ligand-receptor binding and therefore impairs cancer cell proliferation.	Quercetin	11-20	insulin	Homo sapiens	85-92
25241191-1	2014	Although the flavonoid quercetin is known to inhibit activation of insulin receptor signaling, the inhibitory mechanism is largely unknown.	Quercetin	23-32	insulin receptor	Homo sapiens	67-83
25241191-2	2014	In this study, we demonstrate that quercetin suppresses insulin induced dimerization of the insulin receptor (IR) through interfering with ligand-receptor interactions, which reduces the phosphorylation of IR and Akt.	Quercetin	35-44	insulin	Homo sapiens	56-63
25241191-2	2014	In this study, we demonstrate that quercetin suppresses insulin induced dimerization of the insulin receptor (IR) through interfering with ligand-receptor interactions, which reduces the phosphorylation of IR and Akt.	Quercetin	35-44	insulin	Homo sapiens	92-99
25241191-2	2014	In this study, we demonstrate that quercetin suppresses insulin induced dimerization of the insulin receptor (IR) through interfering with ligand-receptor interactions, which reduces the phosphorylation of IR and Akt.	Quercetin	35-44	AKT serine/threonine kinase 1	Homo sapiens	213-216
24657077-8	2014	Our results show that quercetin-3-O-glucuronide, one of the main human phase II metabolites produced after intake of dietary quercetin, displays ERalpha- and ERbeta-dependent estrogenic activity, the functional consequences of which might be related to the protective activity of diets rich in quercetin glycosides.	Quercetin	22-31	estrogen receptor 1	Homo sapiens	145-152
24657077-8	2014	Our results show that quercetin-3-O-glucuronide, one of the main human phase II metabolites produced after intake of dietary quercetin, displays ERalpha- and ERbeta-dependent estrogenic activity, the functional consequences of which might be related to the protective activity of diets rich in quercetin glycosides.	Quercetin	22-31	estrogen receptor 2	Homo sapiens	158-164
24902966-3	2014	In this study, we tested the effects of quercetin on the expression of Bmi-1, a protein regulating mitochondrial function and ROS generation, as a mechanism underlying quercetin-mediated protection against doxorubicin-induced cardiotoxicity.	Quercetin	40-49	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	71-76
24902966-3	2014	In this study, we tested the effects of quercetin on the expression of Bmi-1, a protein regulating mitochondrial function and ROS generation, as a mechanism underlying quercetin-mediated protection against doxorubicin-induced cardiotoxicity.	Quercetin	168-177	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	71-76
24902966-8	2014	The quercetin-mediated protection against doxorubicin toxicity was characterized by decreased expression of Bid, p53 and oxidase (p47 and Nox1) and by increased expression of Bcl-2 and Bmi-1.	Quercetin	4-13	BH3 interacting domain death agonist	Rattus norvegicus	108-111
24902966-8	2014	The quercetin-mediated protection against doxorubicin toxicity was characterized by decreased expression of Bid, p53 and oxidase (p47 and Nox1) and by increased expression of Bcl-2 and Bmi-1.	Quercetin	4-13	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	113-128
24902966-8	2014	The quercetin-mediated protection against doxorubicin toxicity was characterized by decreased expression of Bid, p53 and oxidase (p47 and Nox1) and by increased expression of Bcl-2 and Bmi-1.	Quercetin	4-13	NSFL1 cofactor	Rattus norvegicus	130-133
24902966-8	2014	The quercetin-mediated protection against doxorubicin toxicity was characterized by decreased expression of Bid, p53 and oxidase (p47 and Nox1) and by increased expression of Bcl-2 and Bmi-1.	Quercetin	4-13	NADPH oxidase 1	Rattus norvegicus	138-142
24902966-8	2014	The quercetin-mediated protection against doxorubicin toxicity was characterized by decreased expression of Bid, p53 and oxidase (p47 and Nox1) and by increased expression of Bcl-2 and Bmi-1.	Quercetin	4-13	BCL2, apoptosis regulator	Rattus norvegicus	175-180
24902966-8	2014	The quercetin-mediated protection against doxorubicin toxicity was characterized by decreased expression of Bid, p53 and oxidase (p47 and Nox1) and by increased expression of Bcl-2 and Bmi-1.	Quercetin	4-13	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	185-190
24902966-9	2014	Bmi-1 siRNA abolished the protective effect of quercetin against doxorubicin-induced toxicity in H9c2 cells.	Quercetin	47-56	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	0-5
24902966-10	2014	Furthermore, quercetin protected mice from doxorubicin-induced cardiac dysfunction that was accompanied by reduced ROS levels and lipid peroxidation, but enhanced the expression of Bmi-1 and anti-oxidative superoxide dismutase.	Quercetin	13-22	Bmi1 polycomb ring finger oncogene	Mus musculus	181-186
24902966-11	2014	CONCLUSIONS AND IMPLICATIONS: Our results demonstrate that quercetin decreased doxorubicin-induced cardiotoxicity in vitro and in vivo by reducing oxidative stress by up-regulation of Bmi-1 expression.	Quercetin	59-68	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	184-189
25111660-0	2014	The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway.	Quercetin	23-32	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
25179857-6	2014	Consequently, four compounds, namely apigenin, quercetin, gallocatechin and myricetin, were suggested to have high binding potency to Akt active site.	Quercetin	47-56	AKT serine/threonine kinase 1	Homo sapiens	134-137
24928376-7	2014	The mRNA and protein expression of Smoothened and Glioma1 (Gli1), the members of Hh pathway decreased after treatment with quercetin.	Quercetin	123-132	GLI family zinc finger 1	Homo sapiens	50-57
24928376-7	2014	The mRNA and protein expression of Smoothened and Glioma1 (Gli1), the members of Hh pathway decreased after treatment with quercetin.	Quercetin	123-132	GLI family zinc finger 1	Homo sapiens	59-63
24928376-8	2014	The Bcl-2 and Cyclin D1, targets of Hh signaling, also decreased after treatment with quercetin, respectively.	Quercetin	86-95	BCL2 apoptosis regulator	Homo sapiens	4-9
24928376-8	2014	The Bcl-2 and Cyclin D1, targets of Hh signaling, also decreased after treatment with quercetin, respectively.	Quercetin	86-95	cyclin D1	Homo sapiens	14-23
24928376-9	2014	Quercetin also could increase p53 and Caspase-3 expression.	Quercetin	0-9	tumor protein p53	Homo sapiens	30-33
24928376-9	2014	Quercetin also could increase p53 and Caspase-3 expression.	Quercetin	0-9	caspase 3	Homo sapiens	38-47
24928376-10	2014	Bcr-abl mRNA copies decreased, but no changes of phosphorylated Bcr-abl and Bcr-abl proteins were observed, after treatment with quercetin.	Quercetin	129-138	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-7
25096193-4	2014	We recently demonstrated that quercetin is able to sensitize several leukemia cell lines as well as B cells isolated from patients affected by chronic lymphocytic leukemia (CLL) to death ligand agonists (anti-CD95 and rTRAIL).	Quercetin	30-39	Fas cell surface death receptor	Homo sapiens	209-213
25111660-10	2014	Collectively, our study demonstrated that the berry constituents quercetin, kaempferol, and pterostilbene activated the Nrf2-ARE signaling pathway and exhibited synergistic anti-oxidative stress activity at appropriate concentrations.	Quercetin	65-74	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
25096193-4	2014	We recently demonstrated that quercetin is able to sensitize several leukemia cell lines as well as B cells isolated from patients affected by chronic lymphocytic leukemia (CLL) to death ligand agonists (anti-CD95 and rTRAIL).	Quercetin	30-39	TNF superfamily member 10	Rattus norvegicus	218-224
25138740-0	2014	Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/beta-catenin signaling.	Quercetin	0-9	catenin beta 1	Homo sapiens	115-127
25096193-6	2014	The apoptosis-enhancing activity of quercetin in cell lines and B-CLL cells depends upon the modulated expression and activity of Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family.	Quercetin	36-45	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	130-135
25164625-0	2014	Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent against prostate cancer in an in vivo model by inhibiting the EGFR signaling pathway.	Quercetin	0-9	epidermal growth factor receptor	Rattus norvegicus	134-138
25096193-6	2014	The apoptosis-enhancing activity of quercetin in cell lines and B-CLL cells depends upon the modulated expression and activity of Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family.	Quercetin	36-45	BCL2 apoptosis regulator	Homo sapiens	180-185
25096193-7	2014	Herein, we suggest that the pleotropic activity of quercetin in CLL is obtained by the direct inhibition of key protein kinases, which positively regulate Mcl-1 activity and by indirect downregulation of Mcl-1 mRNA and protein levels acting on its mRNA stability and proteasome-mediated degradation.	Quercetin	51-60	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	155-160
25096193-7	2014	Herein, we suggest that the pleotropic activity of quercetin in CLL is obtained by the direct inhibition of key protein kinases, which positively regulate Mcl-1 activity and by indirect downregulation of Mcl-1 mRNA and protein levels acting on its mRNA stability and proteasome-mediated degradation.	Quercetin	51-60	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	204-209
25138740-3	2014	We have shown that quercetin inhibits the proliferation, adhesion and migration of NT2/D1 cells and downregulates the expression of pluripotency factors SOX2, Oct4 and Nanog.	Quercetin	19-28	SRY-box transcription factor 2	Homo sapiens	153-157
25138740-3	2014	We have shown that quercetin inhibits the proliferation, adhesion and migration of NT2/D1 cells and downregulates the expression of pluripotency factors SOX2, Oct4 and Nanog.	Quercetin	19-28	POU class 5 homeobox 1	Homo sapiens	159-163
25138740-3	2014	We have shown that quercetin inhibits the proliferation, adhesion and migration of NT2/D1 cells and downregulates the expression of pluripotency factors SOX2, Oct4 and Nanog.	Quercetin	19-28	Nanog homeobox	Homo sapiens	168-173
25138740-5	2014	Quercetin antagonized the Wnt/beta-catenin signaling pathway in NT2/D1 cells by inhibiting beta-catenin nuclear translocation and the consequent downregulation of beta-catenin-dependent transcription.	Quercetin	0-9	catenin beta 1	Homo sapiens	30-42
25138740-5	2014	Quercetin antagonized the Wnt/beta-catenin signaling pathway in NT2/D1 cells by inhibiting beta-catenin nuclear translocation and the consequent downregulation of beta-catenin-dependent transcription.	Quercetin	0-9	catenin beta 1	Homo sapiens	91-103
25138740-5	2014	Quercetin antagonized the Wnt/beta-catenin signaling pathway in NT2/D1 cells by inhibiting beta-catenin nuclear translocation and the consequent downregulation of beta-catenin-dependent transcription.	Quercetin	0-9	catenin beta 1	Homo sapiens	91-103
25164625-6	2014	EGFR, PI3K/Akt protein levels were significantly increased in chemically induced cancer rats, which were brought back to normalcy in both DLP &amp; VP (dorsolateral prostate &amp; ventral prostate) by quercetin supplementation.	Quercetin	201-210	epidermal growth factor receptor	Rattus norvegicus	0-4
25164625-8	2014	However, simultaneous quercetin supplementation significantly decreased PCNA, N-cadherin, vimentin, and cyclin D1 protein levels compared to chemically induced cancer rats.	Quercetin	22-31	proliferating cell nuclear antigen	Rattus norvegicus	72-76
25164625-8	2014	However, simultaneous quercetin supplementation significantly decreased PCNA, N-cadherin, vimentin, and cyclin D1 protein levels compared to chemically induced cancer rats.	Quercetin	22-31	cadherin 2	Rattus norvegicus	78-88
26461378-0	2014	The role of HSP90 in Quercetin-induced apoptosis in human papillary thyroid (B-CPAP) cancer cells.	Quercetin	21-30	heat shock protein 90 alpha family class A member 1	Homo sapiens	12-17
26461378-0	2014	The role of HSP90 in Quercetin-induced apoptosis in human papillary thyroid (B-CPAP) cancer cells.	Quercetin	21-30	centromere protein J	Homo sapiens	79-83
25164625-8	2014	However, simultaneous quercetin supplementation significantly decreased PCNA, N-cadherin, vimentin, and cyclin D1 protein levels compared to chemically induced cancer rats.	Quercetin	22-31	vimentin	Rattus norvegicus	90-98
26461378-7	2014	Then, we chose Quercetin concentrations between 10-75microM for 24hours, for the apoptosis and cell cycle analysis in flow cytometry by Annexin V and propidium iodide.	Quercetin	15-24	annexin A5	Homo sapiens	136-145
26461378-9	2014	Finally, we used Western blotting to compare HSP90 and Cleaved-PARP levels in cells treated with Quercetin and the control group.	Quercetin	97-106	heat shock protein 90 alpha family class A member 1	Homo sapiens	45-50
25164625-8	2014	However, simultaneous quercetin supplementation significantly decreased PCNA, N-cadherin, vimentin, and cyclin D1 protein levels compared to chemically induced cancer rats.	Quercetin	22-31	cyclin D1	Rattus norvegicus	104-113
26461378-9	2014	Finally, we used Western blotting to compare HSP90 and Cleaved-PARP levels in cells treated with Quercetin and the control group.	Quercetin	97-106	poly(ADP-ribose) polymerase 1	Homo sapiens	63-67
25164625-13	2014	To conclude from the present study, quercetin was effective in preventing prostate cancer progression by inhibiting the EGFR signaling pathway and by regulating cell adhesion molecules in Sprague Dawley rats.	Quercetin	36-45	epidermal growth factor receptor	Rattus norvegicus	120-124
24561812-13	2014	PI3K/Akt inhibition eliminated the protective effects of exercise training and quercetin treatment.	Quercetin	79-88	AKT serine/threonine kinase 1	Rattus norvegicus	5-8
25017900-0	2014	Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.	Quercetin	14-23	membrane associated ring-CH-type finger 8	Homo sapiens	108-111
25017900-0	2014	Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.	Quercetin	14-23	KRAS proto-oncogene, GTPase	Homo sapiens	132-137
25017900-8	2014	These data demonstrate that sulforaphane, quercetin and GTC complement each other in inhibition of PDA progression by induction of miR-let7-a and inhibition of K-ras.	Quercetin	42-51	membrane associated ring-CH-type finger 8	Homo sapiens	131-134
25017900-8	2014	These data demonstrate that sulforaphane, quercetin and GTC complement each other in inhibition of PDA progression by induction of miR-let7-a and inhibition of K-ras.	Quercetin	42-51	KRAS proto-oncogene, GTPase	Homo sapiens	160-165
25197782-7	2014	Quercetin also increased Sirt1 expression in EPCs.	Quercetin	0-9	sirtuin 1	Homo sapiens	25-30
25197782-8	2014	Inhibition of Sirt1 by a chemical antagonist sirtinol abolished the protective effect of quercetin on eNOS phosphorylation, NO production and cGMP levels following high glucose stress.	Quercetin	89-98	sirtuin 1	Homo sapiens	14-19
25197782-9	2014	To the best of our knowledge, the results provide the first evidence that quercetin protects against high glucose-induced damage by inducing Sirt1-dependent eNOS upregulation in EPCs, and suggest that quercetin is a promising therapeutic agent for diabetic patients undergoing surgery or other invasive procedures.	Quercetin	74-83	sirtuin 1	Homo sapiens	141-146
25197782-9	2014	To the best of our knowledge, the results provide the first evidence that quercetin protects against high glucose-induced damage by inducing Sirt1-dependent eNOS upregulation in EPCs, and suggest that quercetin is a promising therapeutic agent for diabetic patients undergoing surgery or other invasive procedures.	Quercetin	201-210	sirtuin 1	Homo sapiens	141-146
25318886-0	2014	Quercetin suppresses HeLa cells by blocking PI3K/Akt pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	49-52
25318886-6	2014	Quercetin treatment down-regulated the expression of the PI3K and p-Akt.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	68-71
25318886-7	2014	In addition, quercetin could down-regulate expression of bcl-2, up-regulate Bax, but exerted no effect on the overall expression of Akt.	Quercetin	13-22	BCL2 apoptosis regulator	Homo sapiens	57-62
25318886-7	2014	In addition, quercetin could down-regulate expression of bcl-2, up-regulate Bax, but exerted no effect on the overall expression of Akt.	Quercetin	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	76-79
25318886-8	2014	We are led to conclude that quercetin induces apoptosis via PI3k/Akt pathways, and quercetin has potential to be used as an anti-tumor agent against human cervix cancer.	Quercetin	28-37	AKT serine/threonine kinase 1	Homo sapiens	65-68
24561812-14	2014	CONCLUSION: Quercetin enhances exercise-mediated functional recovery after brain ischemia via up-regulation of PI3K/Akt activity to promote antioxidative and antiapoptotic signaling.	Quercetin	12-21	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
24593002-0	2014	Nanocapsulated quercetin downregulates rat hepatic MMP-13 and controls diethylnitrosamine-induced carcinoma.	Quercetin	15-24	matrix metallopeptidase 13	Rattus norvegicus	51-57
24593002-1	2014	AIMS: The aims of our work were to investigate the controlling role and the efficacy of nanocapsulated quercetin drug delivery system on the decrement of inflammatory mediators such as MMP-13 in diethyl nitrosamine (DEN)-induced hepatocarcinogenesis.	Quercetin	103-112	matrix metallopeptidase 13	Rattus norvegicus	185-191
24472704-1	2014	Quercetin has been shown to inhibit intestinal P-glycoprotein-mediated drug efflux.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	47-61
24472704-2	2014	A crossover clinical study was performed in 10 healthy volunteers to assess the effect of single-dose and repeated quercetin intake on the pharmacokinetics of talinolol, a substrate of intestinal P-glycoprotein.	Quercetin	115-124	ATP binding cassette subfamily B member 1	Homo sapiens	196-210
25108166-0	2014	Quercetin attenuates cell apoptosis of oxidant-stressed SK-N-MC cells while suppressing up-regulation of the defensive element, HIF-1alpha.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
25360648-0	2014	[Effect of quercetin on heat shock protein 27 expression in prostate cancer cells].	Quercetin	11-20	heat shock protein family B (small) member 1	Homo sapiens	24-45
25360648-1	2014	OBJECTIVE: To evaluate the mRNA expression of heat shock protein 27 (HSP27) in different prostate cancer cell lines including RWPE-1, LNCaP, PC-3, and TSU-Pr1 and to further analyze the effect of quercetin on PC-3 cell lines.	Quercetin	196-205	heat shock protein family B (small) member 1	Homo sapiens	46-67
25360648-1	2014	OBJECTIVE: To evaluate the mRNA expression of heat shock protein 27 (HSP27) in different prostate cancer cell lines including RWPE-1, LNCaP, PC-3, and TSU-Pr1 and to further analyze the effect of quercetin on PC-3 cell lines.	Quercetin	196-205	heat shock protein family B (small) member 1	Homo sapiens	69-74
25360648-4	2014	RESULTS: RT-PCR and immunofluorescence staining showed that HSP27 expression were highly dependent on the cell types and increased in an order of RWPE-1, LNCaP, PC-3, and TSU-Pr1 after quercetin treatment.	Quercetin	185-194	heat shock protein family B (small) member 1	Homo sapiens	60-65
25360648-8	2014	Quercetin may inhibit HSP27 expression in PC-3 cell.	Quercetin	0-9	heat shock protein family B (small) member 1	Homo sapiens	22-27
25108166-6	2014	However, Quercetin decreased cell contents of HIF-1alpha, Foxo-3a and NICD as well as pro-apoptotic factors including p53 and Bax compared to H2O2-treated cells.	Quercetin	9-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
25108166-6	2014	However, Quercetin decreased cell contents of HIF-1alpha, Foxo-3a and NICD as well as pro-apoptotic factors including p53 and Bax compared to H2O2-treated cells.	Quercetin	9-18	forkhead box O3	Homo sapiens	58-65
25108166-6	2014	However, Quercetin decreased cell contents of HIF-1alpha, Foxo-3a and NICD as well as pro-apoptotic factors including p53 and Bax compared to H2O2-treated cells.	Quercetin	9-18	tumor protein p53	Homo sapiens	118-121
25108166-6	2014	However, Quercetin decreased cell contents of HIF-1alpha, Foxo-3a and NICD as well as pro-apoptotic factors including p53 and Bax compared to H2O2-treated cells.	Quercetin	9-18	BCL2 associated X, apoptosis regulator	Homo sapiens	126-129
28962277-0	2014	Cellular uptake of quercetin and luteolin and their effects on monoamine oxidase-A in human neuroblastoma SH-SY5Y cells.	Quercetin	19-28	monoamine oxidase A	Homo sapiens	63-82
25122155-0	2014	Water-soluble and cleavable quercetin-amino acid conjugates as safe modulators for P-glycoprotein-based multidrug resistance.	Quercetin	28-37	ATP binding cassette subfamily B member 1	Homo sapiens	83-97
28962277-3	2014	Plant flavonoids, such as flavonol quercetin and flavone luteolin, have been suggested to be potential antidepressant compounds because they exert a suppressive effect on the MAO-A reaction.	Quercetin	35-44	monoamine oxidase A	Homo sapiens	175-180
28962277-8	2014	Luteolin and quercetin were incorporated into mitochondria fractions within 1-h incubation and attenuated MAO-A activity slightly but significantly.	Quercetin	13-22	monoamine oxidase A	Homo sapiens	106-111
28962277-11	2014	These data suggest that luteolin and quercetin can be direct inhibitors of MAO-A in nerve cells by targeting mitochondria.	Quercetin	37-46	monoamine oxidase A	Homo sapiens	75-80
25183267-2	2014	Ginkgo biloba extract (GBE) and its flavonoid ingredients (quercetin, kaempferol, and isorhamnetin) could lessen the lipid accumulation associated with up-regulation of the rate-limiting enzyme, carnitine palmitoyltransferase 1A (CPT1A), in the beta-oxidation of long-chain fatty acids.	Quercetin	59-68	carnitine palmitoyltransferase 1A	Homo sapiens	230-235
24731381-6	2014	Increased glucose uptake in L6 myotubes was attributed to GLUT 4 translocation, the most downstream factor in the insulin signalling cascade, which increased two to threefold on chronic pretreatment of quercetin (10 muM) and rutin (100 muM).	Quercetin	202-211	solute carrier family 2 member 4	Homo sapiens	58-64
25183267-7	2014	The regulatory effects of GBE on CPT1A were also verified on the flavonoid ingredients quercetin, kaempferol, and isorhamnetin.	Quercetin	87-96	carnitine palmitoyltransferase 1A	Homo sapiens	33-38
25230879-10	2014	We thus concluded that HDL (mostly HDL3), stimulates PON1 antiatherogenic activities in macrophages, and these PON1 activities were further stimulated by quercetin, or by simvastatin.	Quercetin	154-163	high density lipoprotein (HDL) level 3	Mus musculus	23-26
25230879-10	2014	We thus concluded that HDL (mostly HDL3), stimulates PON1 antiatherogenic activities in macrophages, and these PON1 activities were further stimulated by quercetin, or by simvastatin.	Quercetin	154-163	high density lipoprotein (HDL) level 3	Mus musculus	35-39
25230879-10	2014	We thus concluded that HDL (mostly HDL3), stimulates PON1 antiatherogenic activities in macrophages, and these PON1 activities were further stimulated by quercetin, or by simvastatin.	Quercetin	154-163	paraoxonase 1	Mus musculus	111-115
25002746-6	2014	Among the flavonoids screened, fisetin, luteolin, morin, and quercetin exhibited the strongest effect and produced complete inhibition of OAT1-mediated PAH uptake at a concentration of 50 muM.	Quercetin	61-70	solute carrier family 22 member 6	Homo sapiens	138-142
25002746-6	2014	Among the flavonoids screened, fisetin, luteolin, morin, and quercetin exhibited the strongest effect and produced complete inhibition of OAT1-mediated PAH uptake at a concentration of 50 muM.	Quercetin	61-70	latexin	Homo sapiens	188-191
24929186-4	2014	In this study, we investigated the effects of quercetin-3-O-glucuronide (Q3G), a circulating metabolite of quercetin, which is a type of natural flavonoid, on the catecholamine-induced beta2-adrenergic receptor (beta2-AR)-mediated response in MDA-MB-231 human breast cancer cells expressing beta2-AR.	Quercetin	46-55	adrenoceptor beta 2	Homo sapiens	185-210
24929186-4	2014	In this study, we investigated the effects of quercetin-3-O-glucuronide (Q3G), a circulating metabolite of quercetin, which is a type of natural flavonoid, on the catecholamine-induced beta2-adrenergic receptor (beta2-AR)-mediated response in MDA-MB-231 human breast cancer cells expressing beta2-AR.	Quercetin	46-55	adrenoceptor beta 2	Homo sapiens	212-220
24929186-4	2014	In this study, we investigated the effects of quercetin-3-O-glucuronide (Q3G), a circulating metabolite of quercetin, which is a type of natural flavonoid, on the catecholamine-induced beta2-adrenergic receptor (beta2-AR)-mediated response in MDA-MB-231 human breast cancer cells expressing beta2-AR.	Quercetin	46-55	adrenoceptor beta 2	Homo sapiens	291-299
24950183-9	2014	By quercetin treatment, a plant flavonoid compound which is known to suppress heat shock proteins, or siRNA-mediated gene silencing, both Hsp27 expression and VM capability of BCSCs were suppressed.	Quercetin	3-12	heat shock protein family B (small) member 1	Homo sapiens	138-143
25098616-6	2014	Seven days later, Tn-I and TNF-alpha levels decreased in the rats treated with methylprednisolone, quercetin, and the combination of methylprednisolone and quercetin compared to the rats without therapy, but a statistical significance was found only with the combination therapy (P=0.001 and P=0.011, respectively).	Quercetin	99-108	troponin I3, cardiac type	Rattus norvegicus	18-22
25098616-6	2014	Seven days later, Tn-I and TNF-alpha levels decreased in the rats treated with methylprednisolone, quercetin, and the combination of methylprednisolone and quercetin compared to the rats without therapy, but a statistical significance was found only with the combination therapy (P=0.001 and P=0.011, respectively).	Quercetin	99-108	tumor necrosis factor	Rattus norvegicus	27-36
25098616-6	2014	Seven days later, Tn-I and TNF-alpha levels decreased in the rats treated with methylprednisolone, quercetin, and the combination of methylprednisolone and quercetin compared to the rats without therapy, but a statistical significance was found only with the combination therapy (P=0.001 and P=0.011, respectively).	Quercetin	156-165	troponin I3, cardiac type	Rattus norvegicus	18-22
25098616-6	2014	Seven days later, Tn-I and TNF-alpha levels decreased in the rats treated with methylprednisolone, quercetin, and the combination of methylprednisolone and quercetin compared to the rats without therapy, but a statistical significance was found only with the combination therapy (P=0.001 and P=0.011, respectively).	Quercetin	156-165	tumor necrosis factor	Rattus norvegicus	27-36
24945955-8	2014	In contrast, Cyb5R3 inhibitors (6-propyl-2-thiouracil, p-chloromercuriobenzoate, quercetin, mersalyl, and ebselen) showed similar patterns of inhibition of ROS generation and cytochrome c reduction.	Quercetin	81-90	cytochrome b5 reductase 3	Homo sapiens	13-19
24731381-6	2014	Increased glucose uptake in L6 myotubes was attributed to GLUT 4 translocation, the most downstream factor in the insulin signalling cascade, which increased two to threefold on chronic pretreatment of quercetin (10 muM) and rutin (100 muM).	Quercetin	202-211	latexin	Homo sapiens	216-219
24731381-6	2014	Increased glucose uptake in L6 myotubes was attributed to GLUT 4 translocation, the most downstream factor in the insulin signalling cascade, which increased two to threefold on chronic pretreatment of quercetin (10 muM) and rutin (100 muM).	Quercetin	202-211	latexin	Homo sapiens	236-239
25050614-4	2014	Isobologram graphs revealed synergy of NQO1 induction for a combination of hGSL 9 and quercetin.	Quercetin	86-95	NAD(P)H dehydrogenase, quinone 1	Mus musculus	39-43
25026201-8	2014	That of quercetin compared to genistein was more efficient in reducing the levels of protein carbonylation in hemoglobin and myoglobin, respectively.	Quercetin	8-17	myoglobin	Homo sapiens	125-134
24947867-0	2014	Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin.	Quercetin	124-133	solute carrier organic anion transporter family member 1A2	Homo sapiens	0-39
24947867-0	2014	Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin.	Quercetin	124-133	solute carrier family 22 member 1	Homo sapiens	44-72
24947867-6	2014	Quercetin showed a significantly higher uptake into the HEK293-OATP1A2, HEK293-OATP2A1, HEK293-OATP2B1, and HEK293-OCT1 cells compared to control cells.	Quercetin	0-9	solute carrier organic anion transporter family member 1A2	Homo sapiens	63-70
24947867-6	2014	Quercetin showed a significantly higher uptake into the HEK293-OATP1A2, HEK293-OATP2A1, HEK293-OATP2B1, and HEK293-OCT1 cells compared to control cells.	Quercetin	0-9	solute carrier organic anion transporter family member 2A1	Homo sapiens	79-86
24947867-6	2014	Quercetin showed a significantly higher uptake into the HEK293-OATP1A2, HEK293-OATP2A1, HEK293-OATP2B1, and HEK293-OCT1 cells compared to control cells.	Quercetin	0-9	solute carrier organic anion transporter family member 2B1	Homo sapiens	95-102
24947867-6	2014	Quercetin showed a significantly higher uptake into the HEK293-OATP1A2, HEK293-OATP2A1, HEK293-OATP2B1, and HEK293-OCT1 cells compared to control cells.	Quercetin	0-9	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	115-119
24947867-7	2014	The OATP1A2-, OATP2B1-, and OCT1-mediated quercetin uptake was inhibited by known inhibitors such as naringin, cyclosporin A, and quinidine, respectively.	Quercetin	42-51	solute carrier organic anion transporter family member 1A2	Homo sapiens	4-11
24947867-7	2014	The OATP1A2-, OATP2B1-, and OCT1-mediated quercetin uptake was inhibited by known inhibitors such as naringin, cyclosporin A, and quinidine, respectively.	Quercetin	42-51	solute carrier organic anion transporter family member 2B1	Homo sapiens	14-21
24947867-7	2014	The OATP1A2-, OATP2B1-, and OCT1-mediated quercetin uptake was inhibited by known inhibitors such as naringin, cyclosporin A, and quinidine, respectively.	Quercetin	42-51	solute carrier family 22 member 1	Homo sapiens	28-32
24947867-8	2014	The cellular accumulation of quercetin into HEK293-OATP2A1 cells was not inhibited by prostaglandin E2 and diclofenac.	Quercetin	29-38	solute carrier organic anion transporter family member 2A1	Homo sapiens	51-58
24947867-9	2014	The ionophore carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) reduced the net uptake of quercetin by increasing the uptake in the HEK293-control cells and causing no significant change in the HEK293-OATP2B1 cells indicating that quercetin follows the FCCP-driven proton flux through the plasma membrane.	Quercetin	100-109	solute carrier organic anion transporter family member 2B1	Homo sapiens	211-218
24947867-10	2014	In addition to passive diffusion, the SLC transporters OATP1A2, OATP2B1, and OCT1 contribute to cellular accumulation of quercetin.	Quercetin	121-130	C-C motif chemokine ligand 21	Homo sapiens	38-41
24947867-10	2014	In addition to passive diffusion, the SLC transporters OATP1A2, OATP2B1, and OCT1 contribute to cellular accumulation of quercetin.	Quercetin	121-130	solute carrier organic anion transporter family member 1A2	Homo sapiens	55-62
24947867-10	2014	In addition to passive diffusion, the SLC transporters OATP1A2, OATP2B1, and OCT1 contribute to cellular accumulation of quercetin.	Quercetin	121-130	solute carrier organic anion transporter family member 2B1	Homo sapiens	64-71
24947867-10	2014	In addition to passive diffusion, the SLC transporters OATP1A2, OATP2B1, and OCT1 contribute to cellular accumulation of quercetin.	Quercetin	121-130	solute carrier family 22 member 1	Homo sapiens	77-81
25050614-6	2014	Interestingly, synergy of NQO1 induction was also seen for physiologically relevant doses of sulforaphane (SF) and quercetin, two key bioactives present in broccoli.	Quercetin	115-124	NAD(P)H dehydrogenase, quinone 1	Mus musculus	26-30
24962584-3	2014	Here, employing affinity chromatography and mass spectrometry, we identified heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) as a direct target of quercetin.	Quercetin	152-161	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	77-119
25337190-3	2014	Our findings indicated that co-administration of 10 mg/kg/day quercetin with estrogen and progesterone caused a significant decrease in the size of uterine lumen and epithelial heights with lower PCNA protein and mRNA expression as compared to estrogen plus progesterone-only treatment (P &lt; 0.05).	Quercetin	62-71	proliferating cell nuclear antigen	Rattus norvegicus	196-200
25337190-4	2014	Concomitant treatment with estrogen and progesterone with 100 mg/kg/day quercetin resulted in a marked increase in the number of glands with increased PCNA protein and mRNA expression.	Quercetin	72-81	proliferating cell nuclear antigen	Rattus norvegicus	151-155
25132926-4	2014	Cell viability was examined by acridine orange staining following treatments for 48 or 144 h. Effects of quercetin and genistein on ERbeta transcriptional transactivation were examined by luciferase activity in HCT8-beta8-expressing cells transiently transfected with a pEREtkLUC reporter vector.	Quercetin	105-114	estrogen receptor 2	Homo sapiens	132-138
25132926-10	2014	Furthermore, genistein and quercetin (50 mumol/L), as well as 10 nmol/L 17beta-E2 significantly increased ERbeta mRNA levels in HCT8-beta8-expressing cells (P &lt; 0.05).	Quercetin	27-36	estrogen receptor 2	Homo sapiens	106-112
25132926-11	2014	In addition, treatment of HCT8-pSV2neo-expressing cells with 50 micromol/L quercetin or 10 nmol/L 17beta-E2 significantly increased ERbeta mRNA levels compared to untreated controls (P &lt; 0.05), though the absolute levels were much lower than in HCT8-beta8-expressing cells.	Quercetin	75-84	estrogen receptor 2	Homo sapiens	132-138
25132926-12	2014	CONCLUSION: The antitumorigenic effects of the phytoestrogenic compounds quercetin and genistein on colon cancers cells occur through ERbeta activity and expression.	Quercetin	73-82	estrogen receptor 2	Homo sapiens	134-140
24963805-0	2014	Induction of hepatic apolipoprotein A-I gene expression by the isoflavones quercetin and isoquercetrin.	Quercetin	75-84	apolipoprotein A1	Homo sapiens	21-39
24963805-5	2014	KEY FINDINGS: Quercetin and isoquercetin, but not myrecetin, induced apo A-I protein and mRNA synthesis, and induced apo A-I promoter activity.	Quercetin	14-23	apolipoprotein A1	Homo sapiens	69-76
24963805-5	2014	KEY FINDINGS: Quercetin and isoquercetin, but not myrecetin, induced apo A-I protein and mRNA synthesis, and induced apo A-I promoter activity.	Quercetin	14-23	apolipoprotein A1	Homo sapiens	117-124
24963805-6	2014	Induction by quercetin required an estrogen-responsive region of the apo A-I promoter.	Quercetin	13-22	apolipoprotein A1	Homo sapiens	69-76
24963805-7	2014	Addition of estrogen receptor blocker ICI-182780 to quercetin-treated cells inhibited the effects of quercetin on apo A-I gene expression.	Quercetin	52-61	apolipoprotein A1	Homo sapiens	114-121
24963805-7	2014	Addition of estrogen receptor blocker ICI-182780 to quercetin-treated cells inhibited the effects of quercetin on apo A-I gene expression.	Quercetin	101-110	apolipoprotein A1	Homo sapiens	114-121
24963805-8	2014	Down-regulation of ESR1 with ESR1 siRNA had no effect on basal apo A-I gene expression; however it prevented quercetin-mediated induction of apo A-I gene expression.	Quercetin	109-118	estrogen receptor 1	Homo sapiens	19-23
24963805-8	2014	Down-regulation of ESR1 with ESR1 siRNA had no effect on basal apo A-I gene expression; however it prevented quercetin-mediated induction of apo A-I gene expression.	Quercetin	109-118	apolipoprotein A1	Homo sapiens	141-148
24963805-9	2014	SIGNIFICANCE: We conclude that quercetin induces apo A-I gene expression at least in part through induction of ESR1 and may be useful in treating hypoalphalipoproteinemia.	Quercetin	31-40	apolipoprotein A1	Homo sapiens	49-56
24963805-9	2014	SIGNIFICANCE: We conclude that quercetin induces apo A-I gene expression at least in part through induction of ESR1 and may be useful in treating hypoalphalipoproteinemia.	Quercetin	31-40	estrogen receptor 1	Homo sapiens	111-115
24927684-0	2014	Amphiphilic carboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel.	Quercetin	35-44	phosphoglycolate phosphatase	Homo sapiens	60-64
24962584-3	2014	Here, employing affinity chromatography and mass spectrometry, we identified heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) as a direct target of quercetin.	Quercetin	152-161	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	121-128
24962584-4	2014	A specific interaction between quercetin and hnRNPA1 was validated by immunoblotting and in vitro binding experiments.	Quercetin	31-40	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	45-52
24962584-5	2014	We found that quercetin bound the C-terminal region of hnRNPA1, impairing the ability of hnRNPA1 to shuttle between the nucleus and cytoplasm and ultimately resulting in its cytoplasmic retention.	Quercetin	14-23	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	55-62
24962584-5	2014	We found that quercetin bound the C-terminal region of hnRNPA1, impairing the ability of hnRNPA1 to shuttle between the nucleus and cytoplasm and ultimately resulting in its cytoplasmic retention.	Quercetin	14-23	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	89-96
24962584-6	2014	In addition, hnRNPA1 was recruited to stress granules after treatment of cells with quercetin for up to 48 h, and the levels of cIAP1 (cellular inhibitor of apoptosis), an internal ribosome entry site translation-dependent protein, were reduced by hnRNPA1 regulation.	Quercetin	84-93	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	13-20
24962584-7	2014	This is the first report that anti-cancer effects of quercetin are mediated, in part, by impairing functions of hnRNPA1, insights that were obtained using a chemical proteomics strategy.	Quercetin	53-62	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	112-119
25098714-5	2014	Treatment with quercetin significantly decreased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Quercetin	15-24	glutamic pyruvic transaminase, soluble	Mus musculus	63-87
25098714-5	2014	Treatment with quercetin significantly decreased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Quercetin	15-24	glutamic pyruvic transaminase, soluble	Mus musculus	89-92
25098714-5	2014	Treatment with quercetin significantly decreased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Quercetin	15-24	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	98-124
25098714-5	2014	Treatment with quercetin significantly decreased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Quercetin	15-24	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	126-129
25098714-11	2014	NF-kappaB and TGF-beta production was decreased after treatment with quercetin, indicating that the antifibrotic effect of quercetin is associated with its ability to modulate NF-kappaB and TGF-beta production.	Quercetin	69-78	transforming growth factor, beta 1	Mus musculus	14-22
25098714-11	2014	NF-kappaB and TGF-beta production was decreased after treatment with quercetin, indicating that the antifibrotic effect of quercetin is associated with its ability to modulate NF-kappaB and TGF-beta production.	Quercetin	69-78	transforming growth factor, beta 1	Mus musculus	190-198
25098714-11	2014	NF-kappaB and TGF-beta production was decreased after treatment with quercetin, indicating that the antifibrotic effect of quercetin is associated with its ability to modulate NF-kappaB and TGF-beta production.	Quercetin	123-132	transforming growth factor, beta 1	Mus musculus	14-22
25098714-11	2014	NF-kappaB and TGF-beta production was decreased after treatment with quercetin, indicating that the antifibrotic effect of quercetin is associated with its ability to modulate NF-kappaB and TGF-beta production.	Quercetin	123-132	transforming growth factor, beta 1	Mus musculus	190-198
24299158-6	2014	Significantly elevated caspase-3 activity was noted after treatment with genistein (10(-9)-10(-7) mol/l), as well as with resveratrol and quercetin (10(-9)-10(-5) mol/l).	Quercetin	138-147	caspase 3	Homo sapiens	23-32
24846663-6	2014	Quercetin reduced cognitive deficits, the number of TUNEL- and ED-1-positive cells, the protein expressions of Bax and cleaved-caspase-3 proteins, and the levels of TBARS and proinflammatory cytokines, and increased the activity of antioxidant enzymes (GSH-Px, SOD, and CAT) at 1 week after TBI.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Rattus norvegicus	111-114
24846663-6	2014	Quercetin reduced cognitive deficits, the number of TUNEL- and ED-1-positive cells, the protein expressions of Bax and cleaved-caspase-3 proteins, and the levels of TBARS and proinflammatory cytokines, and increased the activity of antioxidant enzymes (GSH-Px, SOD, and CAT) at 1 week after TBI.	Quercetin	0-9	catalase	Rattus norvegicus	270-273
24299158-9	2014	Estrogen receptor (ER) alpha expression was significantly increased with 17beta-estradiol, whereas ERbeta expression was significantly elevated in the cultures with genistein, resveratrol, and quercetin.	Quercetin	193-202	estrogen receptor 2	Homo sapiens	99-105
25057854-0	2014	Quercetin, luteolin, and epigallocatechin gallate promote glucose disposal in adipocytes with regulation of AMP-activated kinase and/or sirtuin 1 activity.	Quercetin	0-9	sirtuin 1	Homo sapiens	136-145
25009654-10	2014	These results suggested that the apoptosis induced by quercetin was via the inhibition of FASN.	Quercetin	54-63	fatty acid synthase	Homo sapiens	90-94
23949287-3	2014	In the present study, the antitumor effects of combining Hsp90 inhibitor (17DMAG) and Hsp70 inhibitor (quercetin) with FMP-mediated hyperthermia were examined.	Quercetin	103-112	heat shock protein 1B	Mus musculus	86-91
23949287-8	2014	RESULTS: In the group pretreated with hyperthermia + quercetin + 17DMAG, Akt expression was reduced in vitro, the incidence of apoptosis within tumors was greater, and tumor growth was significantly suppressed 20 days after FMP injection in vivo, compared with other treatment groups.	Quercetin	53-62	thymoma viral proto-oncogene 1	Mus musculus	73-76
25009654-4	2014	Previous studies have shown that quercetin has potent inhibitory effects on animal fatty acid synthase (FASN).	Quercetin	33-42	fatty acid synthase	Homo sapiens	83-102
25009654-4	2014	Previous studies have shown that quercetin has potent inhibitory effects on animal fatty acid synthase (FASN).	Quercetin	33-42	fatty acid synthase	Homo sapiens	104-108
25009654-8	2014	In the present study, it was found that quercetin could induce apoptosis in human liver cancer HepG2 cells with overexpression of FASN.	Quercetin	40-49	fatty acid synthase	Homo sapiens	130-134
25057854-5	2014	Quercetin, luteolin, and epigallocatechin gallate suppressed nuclear factor-kappaB activation by inhibition of p65 phosphorylation with beneficial regulation of adipokine expression, whereas these actions were diminished by coincubation with compound C. The sirtuin 1 inhibitor nicotinamide attenuated the effects of luteolin and EGCG on p65 phosphorylation and adipokine expression without any influence on the activity of quercetin.	Quercetin	0-9	RELA proto-oncogene, NF-kB subunit	Homo sapiens	111-114
25057854-5	2014	Quercetin, luteolin, and epigallocatechin gallate suppressed nuclear factor-kappaB activation by inhibition of p65 phosphorylation with beneficial regulation of adipokine expression, whereas these actions were diminished by coincubation with compound C. The sirtuin 1 inhibitor nicotinamide attenuated the effects of luteolin and EGCG on p65 phosphorylation and adipokine expression without any influence on the activity of quercetin.	Quercetin	0-9	sirtuin 1	Homo sapiens	258-267
25057854-5	2014	Quercetin, luteolin, and epigallocatechin gallate suppressed nuclear factor-kappaB activation by inhibition of p65 phosphorylation with beneficial regulation of adipokine expression, whereas these actions were diminished by coincubation with compound C. The sirtuin 1 inhibitor nicotinamide attenuated the effects of luteolin and EGCG on p65 phosphorylation and adipokine expression without any influence on the activity of quercetin.	Quercetin	0-9	RELA proto-oncogene, NF-kB subunit	Homo sapiens	338-341
25057854-5	2014	Quercetin, luteolin, and epigallocatechin gallate suppressed nuclear factor-kappaB activation by inhibition of p65 phosphorylation with beneficial regulation of adipokine expression, whereas these actions were diminished by coincubation with compound C. The sirtuin 1 inhibitor nicotinamide attenuated the effects of luteolin and EGCG on p65 phosphorylation and adipokine expression without any influence on the activity of quercetin.	Quercetin	424-433	sirtuin 1	Homo sapiens	258-267
25057854-6	2014	Results of Western blot and fluorescence microscopy also showed that quercetin, luteolin, and epigallocatechin gallate increased Akt substrate of 160 kDa phosphorylation and promoted 2-deoxy-D-glucose uptake by adipocytes under basal and inflammatory conditions.	Quercetin	69-78	AKT serine/threonine kinase 1	Homo sapiens	129-132
25057854-7	2014	These findings suggested that quercetin, luteolin, and epigallocatechin gallate inhibited inflammation and promoted glucose disposal in adipocytes with the regulation of AMP-activated kinase and/or sirtuin 1.	Quercetin	30-39	sirtuin 1	Homo sapiens	198-207
28962259-0	2014	Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow.	Quercetin	22-31	polymerase (DNA directed), gamma	Mus musculus	91-95
28962259-0	2014	Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow.	Quercetin	22-31	transcription factor A, mitochondrial	Mus musculus	121-125
28962259-5	2014	In the mice exposed to TBI combined with quercetin, we found: (1) the radiation-induced increase of mtDNAcn was inhibited with a concurrent significant decrease in POLG expression; (2) TFAM expression was significantly increased; and (3) the expression of POLG2 was not influenced by the treatments.	Quercetin	41-50	polymerase (DNA directed), gamma	Mus musculus	164-168
28962259-5	2014	In the mice exposed to TBI combined with quercetin, we found: (1) the radiation-induced increase of mtDNAcn was inhibited with a concurrent significant decrease in POLG expression; (2) TFAM expression was significantly increased; and (3) the expression of POLG2 was not influenced by the treatments.	Quercetin	41-50	transcription factor A, mitochondrial	Mus musculus	185-189
28962259-5	2014	In the mice exposed to TBI combined with quercetin, we found: (1) the radiation-induced increase of mtDNAcn was inhibited with a concurrent significant decrease in POLG expression; (2) TFAM expression was significantly increased; and (3) the expression of POLG2 was not influenced by the treatments.	Quercetin	41-50	polymerase (DNA directed), gamma 2, accessory subunit	Mus musculus	256-261
25005324-0	2014	[Erythropoietin as a protective factor in radiotherapy on cells in the central nervous system: quercetin and its potential associative effect].	Quercetin	95-104	erythropoietin	Homo sapiens	1-15
24946265-8	2014	Glutathione, SOD, catalase, and glutathione-S-transferase levels were also found to be increased on quercetin supplementation.	Quercetin	100-109	catalase	Mus musculus	18-26
24946265-8	2014	Glutathione, SOD, catalase, and glutathione-S-transferase levels were also found to be increased on quercetin supplementation.	Quercetin	100-109	hematopoietic prostaglandin D synthase	Mus musculus	32-57
24952260-0	2014	Quercetin protects the impairment of memory and anxiogenic-like behavior in rats exposed to cadmium: Possible involvement of the acetylcholinesterase and Na(+),K(+)-ATPase activities.	Quercetin	0-9	acetylcholinesterase	Rattus norvegicus	129-149
24952260-9	2014	Quercetin prevented these effects in AChE and Na(+),K(+)-ATPase activities.	Quercetin	0-9	acetylcholinesterase	Rattus norvegicus	37-41
24952260-13	2014	Co-treatment with quercetin prevented reduction in T-SH, GSH, and GR activities and the rise of GST activity.	Quercetin	18-27	hematopoietic prostaglandin D synthase	Rattus norvegicus	96-99
24952260-14	2014	The present findings show that quercetin prevents alterations in oxidative stress parameters as well as AChE and Na(+),K(+)-ATPase activities, consequently preventing memory impairment and anxiogenic-like behavior displayed by Cd exposure.	Quercetin	31-40	acetylcholinesterase	Rattus norvegicus	104-108
25221598-2	2014	Zinc sulfate and quercetin induced and inhibited the expression of HSP72, respectively.	Quercetin	17-26	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	67-72
24769323-9	2014	The results showed that quercetin significantly reduced apoptosis rate, improved cardiac function, decreased levels of creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH).	Quercetin	24-33	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	141-167
24769323-9	2014	The results showed that quercetin significantly reduced apoptosis rate, improved cardiac function, decreased levels of creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH).	Quercetin	24-33	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	169-172
24769323-10	2014	Quercetin also restrained the oxidative stress related to myocardial ischemia injury as evidenced by decreased malondialdehyde (MDA), and elevated GSH, superoxide dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), glutathione reductase (GR) activity.	Quercetin	0-9	catalase	Rattus norvegicus	180-188
24769323-10	2014	Quercetin also restrained the oxidative stress related to myocardial ischemia injury as evidenced by decreased malondialdehyde (MDA), and elevated GSH, superoxide dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), glutathione reductase (GR) activity.	Quercetin	0-9	catalase	Rattus norvegicus	190-193
24769323-10	2014	Quercetin also restrained the oxidative stress related to myocardial ischemia injury as evidenced by decreased malondialdehyde (MDA), and elevated GSH, superoxide dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), glutathione reductase (GR) activity.	Quercetin	0-9	glutathione peroxidase 1	Rattus norvegicus	220-226
24769323-10	2014	Quercetin also restrained the oxidative stress related to myocardial ischemia injury as evidenced by decreased malondialdehyde (MDA), and elevated GSH, superoxide dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), glutathione reductase (GR) activity.	Quercetin	0-9	glutathione-disulfide reductase	Rattus norvegicus	229-250
24769323-10	2014	Quercetin also restrained the oxidative stress related to myocardial ischemia injury as evidenced by decreased malondialdehyde (MDA), and elevated GSH, superoxide dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), glutathione reductase (GR) activity.	Quercetin	0-9	glutathione-disulfide reductase	Rattus norvegicus	252-254
25024815-5	2014	RESULTS: Investigations with several molecules that have been reported to be associated with AMPK activation (A-769662, 5-aminoimidazole-4-carboxamide-1-b-D-ribofuranoside, EGCG, KU-55933, quercetin, resveratrol and salicylates) or AMPK inhibition (compound C) failed to reveal increased medium acidification and increased glucose uptake in colon cancer cells as previously established with metformin and phenformin.	Quercetin	189-198	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	93-97
24769323-12	2014	Our results still showed that quercetin pretreatment significantly inhibited the apoptosis by decreasing the number of apoptotic cells, decreasing the level of cleaved Bax, and increasing the level of Bcl-2 in rats subjected to I/R injury.	Quercetin	30-39	BCL2 associated X, apoptosis regulator	Rattus norvegicus	168-171
24769323-12	2014	Our results still showed that quercetin pretreatment significantly inhibited the apoptosis by decreasing the number of apoptotic cells, decreasing the level of cleaved Bax, and increasing the level of Bcl-2 in rats subjected to I/R injury.	Quercetin	30-39	BCL2, apoptosis regulator	Rattus norvegicus	201-206
24769323-13	2014	Simultaneously, quercetin pretreatment markedly increased the phosphorylation of Akt.	Quercetin	16-25	AKT serine/threonine kinase 1	Rattus norvegicus	81-84
24769323-15	2014	It can be concluded that quercetin pretreatment was protected against myocardium IR injury by decreasing oxidative stress, repressing inflammatory cascade, inhibiting apoptosis in vivo and PI3K/Akt pathway involved in the anti-apoptotic effect.	Quercetin	25-34	AKT serine/threonine kinase 1	Rattus norvegicus	194-197
25221598-4	2014	Our results showed that compared with the control group, the expression of HSP72 in retinal ganglion cells and the lateral geniculate body was increased after the injection of zinc sulfate, but was decreased after the injection of quercetin.	Quercetin	231-240	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	75-80
24760952-5	2014	Quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, Cyclin D1, Cdk2, and Cdk7 down-regulation.	Quercetin	0-9	tumor protein p53	Homo sapiens	54-57
24726691-10	2014	Resveratrol, quercetin and morin were the only nutrients that significantly inhibited AR mRNA expression.	Quercetin	13-22	androgen receptor	Homo sapiens	86-88
24726691-13	2014	We confirm that resveratrol, morin and quercetin may achieve such effect through reduced expression of AR.	Quercetin	39-48	androgen receptor	Homo sapiens	103-105
24853321-0	2014	Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK.	Quercetin	12-21	melanogenesis associated transcription factor	Mus musculus	143-147
24853321-0	2014	Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK.	Quercetin	12-21	mitogen-activated protein kinase 14	Mus musculus	152-160
25150121-8	2014	Compared with mice not exposed to heat, quercetin-treated mice had significantly lower interleukin 6 (P &lt; .01) and higher superoxide dismutase levels (P &lt; .01), whereas vehicle-treated mice had significantly lower total glutathione and higher 8-isoprostane levels in the circulation after heat exposure.	Quercetin	40-49	interleukin 6	Mus musculus	87-100
23024111-11	2014	Accordingly, this study suggests that the reduction in oxidative stress and modulation of HO-1 mRNA expression and TNF-alpha release by curcumin and quercetin may contribute to the synergistic anti-inflammatory effects of these two flavonoids upon combination.	Quercetin	149-158	heme oxygenase 1	Rattus norvegicus	90-94
23024111-11	2014	Accordingly, this study suggests that the reduction in oxidative stress and modulation of HO-1 mRNA expression and TNF-alpha release by curcumin and quercetin may contribute to the synergistic anti-inflammatory effects of these two flavonoids upon combination.	Quercetin	149-158	tumor necrosis factor	Rattus norvegicus	115-124
24727558-7	2014	In addition, compared to Quercetin, the tested synthetic product reveals a relatively-strong antiradical activity towards the DPPH (activity percentage of 81.22%) free radicals and significantly decreased the reactive oxygen species such as (O2(-)) formation evaluated by the non-enzymatic (nitroblue tetrazolium/riboflavine) and the enzymatic (xanthine/xanthine oxidase) systems.	Quercetin	25-34	xanthine dehydrogenase	Mus musculus	354-370
24943009-0	2014	[Effects of quercetin in pregnant and lactation period on weight and expression of insulin-like growth factors-1 mRNA of obese female rats offspring].	Quercetin	12-21	insulin-like growth factor 1	Rattus norvegicus	83-112
24943009-1	2014	OBJECTIVE: To study the effect of quercetin given during pregnancy and lactation period of obese rats on weight and expression of insulin-like growth factors-1 (IGF-1) mRNA of the offspring.	Quercetin	34-43	insulin-like growth factor 1	Rattus norvegicus	130-166
24943009-10	2014	The quercetin also reduced the expression of IGF-1 mRNA in livers of the F1 generation, and this effect remained to the adulthood.	Quercetin	4-13	insulin-like growth factor 1	Rattus norvegicus	45-50
24943009-12	2014	CONCLUSION: The averaged birth weight of the F1 generation of obese pregnant rats was significantly increased, and quercetin could effectively inhibit the expression of IGF-1 mRNA in livers of F1 generation to decrease cell proliferation and cell differentiation.	Quercetin	115-124	insulin-like growth factor 1	Rattus norvegicus	169-174
24845384-6	2014	We further confirmed Quercetin, a reported inhibitor of T-bet, could target USP10.	Quercetin	21-30	T-box transcription factor 21	Homo sapiens	56-61
24845384-6	2014	We further confirmed Quercetin, a reported inhibitor of T-bet, could target USP10.	Quercetin	21-30	ubiquitin specific peptidase 10	Homo sapiens	76-81
24845384-7	2014	Quercetin treatment downregulated USP10 and promoted T-bet degradation in a proteasome dependent way.	Quercetin	0-9	ubiquitin specific peptidase 10	Homo sapiens	34-39
24845384-7	2014	Quercetin treatment downregulated USP10 and promoted T-bet degradation in a proteasome dependent way.	Quercetin	0-9	T-box transcription factor 21	Homo sapiens	53-58
24905073-5	2014	Western-blot analysis of caspase-3 showed that quercetin inhibited the cleaved activation of caspase-3 induced by clivorine.	Quercetin	47-56	caspase 3	Mus musculus	25-34
24905073-5	2014	Western-blot analysis of caspase-3 showed that quercetin inhibited the cleaved activation of caspase-3 induced by clivorine.	Quercetin	47-56	caspase 3	Mus musculus	93-102
24902789-0	2014	Quercetin sensitizes human glioblastoma cells to temozolomide in vitro via inhibition of Hsp27.	Quercetin	0-9	heat shock protein family B (small) member 1	Homo sapiens	89-94
24902789-1	2014	AIM: Quercetin is an effective Hsp27 inhibitor and has been reported to facilitate tumor cell apoptosis.	Quercetin	5-14	heat shock protein family B (small) member 1	Homo sapiens	31-36
24760952-5	2014	Quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, Cyclin D1, Cdk2, and Cdk7 down-regulation.	Quercetin	0-9	cyclin dependent kinase inhibitor 1A	Homo sapiens	62-65
24760952-5	2014	Quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, Cyclin D1, Cdk2, and Cdk7 down-regulation.	Quercetin	0-9	cyclin D1	Homo sapiens	81-90
24760952-5	2014	Quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, Cyclin D1, Cdk2, and Cdk7 down-regulation.	Quercetin	0-9	cyclin dependent kinase 2	Homo sapiens	92-96
24760952-5	2014	Quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, Cyclin D1, Cdk2, and Cdk7 down-regulation.	Quercetin	0-9	cyclin dependent kinase 7	Homo sapiens	102-106
24760952-6	2014	These results suggested that the induction of G2/M arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of Cyclin D1, Cdk2, and Cdk7 levels, and generation of reactive oxygen species in cells.	Quercetin	88-97	tumor protein p53	Homo sapiens	141-144
24760952-6	2014	These results suggested that the induction of G2/M arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of Cyclin D1, Cdk2, and Cdk7 levels, and generation of reactive oxygen species in cells.	Quercetin	88-97	cyclin dependent kinase inhibitor 1A	Homo sapiens	149-152
24760952-6	2014	These results suggested that the induction of G2/M arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of Cyclin D1, Cdk2, and Cdk7 levels, and generation of reactive oxygen species in cells.	Quercetin	88-97	cyclin D1	Homo sapiens	166-175
24760952-6	2014	These results suggested that the induction of G2/M arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of Cyclin D1, Cdk2, and Cdk7 levels, and generation of reactive oxygen species in cells.	Quercetin	88-97	cyclin dependent kinase 2	Homo sapiens	177-181
24760952-6	2014	These results suggested that the induction of G2/M arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of Cyclin D1, Cdk2, and Cdk7 levels, and generation of reactive oxygen species in cells.	Quercetin	88-97	cyclin dependent kinase 7	Homo sapiens	187-191
24666891-6	2014	Quercetin administration modulated expression level of ER stress genes coding for glucose-regulated protein 78 (GRP78) and C/EBP-homologous protein (CHOP), and antioxidant enzymes such as superoxide dismutase and catalase, along with free radical generation assessed by malondialdehyde assay.	Quercetin	0-9	heat shock protein family A (Hsp70) member 5	Homo sapiens	82-110
24666891-6	2014	Quercetin administration modulated expression level of ER stress genes coding for glucose-regulated protein 78 (GRP78) and C/EBP-homologous protein (CHOP), and antioxidant enzymes such as superoxide dismutase and catalase, along with free radical generation assessed by malondialdehyde assay.	Quercetin	0-9	heat shock protein family A (Hsp70) member 5	Homo sapiens	112-117
24666891-6	2014	Quercetin administration modulated expression level of ER stress genes coding for glucose-regulated protein 78 (GRP78) and C/EBP-homologous protein (CHOP), and antioxidant enzymes such as superoxide dismutase and catalase, along with free radical generation assessed by malondialdehyde assay.	Quercetin	0-9	DNA damage inducible transcript 3	Homo sapiens	123-147
24666891-6	2014	Quercetin administration modulated expression level of ER stress genes coding for glucose-regulated protein 78 (GRP78) and C/EBP-homologous protein (CHOP), and antioxidant enzymes such as superoxide dismutase and catalase, along with free radical generation assessed by malondialdehyde assay.	Quercetin	0-9	DNA damage inducible transcript 3	Homo sapiens	149-153
24666891-6	2014	Quercetin administration modulated expression level of ER stress genes coding for glucose-regulated protein 78 (GRP78) and C/EBP-homologous protein (CHOP), and antioxidant enzymes such as superoxide dismutase and catalase, along with free radical generation assessed by malondialdehyde assay.	Quercetin	0-9	catalase	Homo sapiens	213-221
24666891-8	2014	CONCLUSION: The current study indicates that quercetin modulated stress responsive genes GRP78 and CHOP, helping endothelial cells prevent TUN-induced ER stress.	Quercetin	45-54	heat shock protein family A (Hsp70) member 5	Homo sapiens	89-94
24666891-8	2014	CONCLUSION: The current study indicates that quercetin modulated stress responsive genes GRP78 and CHOP, helping endothelial cells prevent TUN-induced ER stress.	Quercetin	45-54	DNA damage inducible transcript 3	Homo sapiens	99-103
24647664-0	2014	Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells.	Quercetin	0-9	transient receptor potential cation channel subfamily M member 7	Homo sapiens	52-57
24793929-11	2014	Treatment with quercetin decreased the number of caspase-3 and TUNEL positive cells.	Quercetin	15-24	caspase 3	Rattus norvegicus	49-58
24337631-1	2014	Previously, we reported that isorhamnentin, a 3"-O-methylated metabolite of quercetin, reduced inducible nitric oxide synthase (iNOS) expression and NO production.	Quercetin	76-85	nitric oxide synthase 2	Rattus norvegicus	95-126
24337631-1	2014	Previously, we reported that isorhamnentin, a 3"-O-methylated metabolite of quercetin, reduced inducible nitric oxide synthase (iNOS) expression and NO production.	Quercetin	76-85	nitric oxide synthase 2	Rattus norvegicus	128-132
24530315-0	2014	Quercetin mitigates lead acetate-induced behavioral and histological alterations via suppression of oxidative stress, Hsp-70, Bak and upregulation of Bcl-2.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	118-124
24530315-0	2014	Quercetin mitigates lead acetate-induced behavioral and histological alterations via suppression of oxidative stress, Hsp-70, Bak and upregulation of Bcl-2.	Quercetin	0-9	BCL2-antagonist/killer 1	Rattus norvegicus	126-129
24530315-0	2014	Quercetin mitigates lead acetate-induced behavioral and histological alterations via suppression of oxidative stress, Hsp-70, Bak and upregulation of Bcl-2.	Quercetin	0-9	BCL2, apoptosis regulator	Rattus norvegicus	150-155
24530315-9	2014	Quercetin however, restored the normal morphology of brain and the expressions of Bak, Bcl-2 and Hsp-70.	Quercetin	0-9	BCL2-antagonist/killer 1	Rattus norvegicus	82-85
24530315-9	2014	Quercetin however, restored the normal morphology of brain and the expressions of Bak, Bcl-2 and Hsp-70.	Quercetin	0-9	BCL2, apoptosis regulator	Rattus norvegicus	87-92
24530315-9	2014	Quercetin however, restored the normal morphology of brain and the expressions of Bak, Bcl-2 and Hsp-70.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	97-103
24647664-7	2014	Quercetin was found to induce the apoptosis of these cells, and this apoptosis was inhibited by SB203580 (a p38 kinase inhibitor), SP600125 (a JNK inhibitor) and PD98059 (an ERK inhibitor).	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	143-146
24647664-7	2014	Quercetin was found to induce the apoptosis of these cells, and this apoptosis was inhibited by SB203580 (a p38 kinase inhibitor), SP600125 (a JNK inhibitor) and PD98059 (an ERK inhibitor).	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	174-177
24647664-8	2014	In addition, quercetin inhibited TRPM7 currents in the AGS cells and in human embryo kidney (HEK)293 cells which overexpress TRPM7 channels.	Quercetin	13-22	transient receptor potential cation channel subfamily M member 7	Homo sapiens	33-38
24647664-8	2014	In addition, quercetin inhibited TRPM7 currents in the AGS cells and in human embryo kidney (HEK)293 cells which overexpress TRPM7 channels.	Quercetin	13-22	transient receptor potential cation channel subfamily M member 7	Homo sapiens	125-130
24647664-9	2014	Furthermore, treatment with quercetin increased the apoptosis of HEK293 cells, which overexpress TRPM7, indicating that the upregulation of TRPM7 channels underlies quercetin-induced cell death.	Quercetin	28-37	transient receptor potential cation channel subfamily M member 7	Homo sapiens	97-102
24647664-9	2014	Furthermore, treatment with quercetin increased the apoptosis of HEK293 cells, which overexpress TRPM7, indicating that the upregulation of TRPM7 channels underlies quercetin-induced cell death.	Quercetin	28-37	transient receptor potential cation channel subfamily M member 7	Homo sapiens	140-145
24647664-9	2014	Furthermore, treatment with quercetin increased the apoptosis of HEK293 cells, which overexpress TRPM7, indicating that the upregulation of TRPM7 channels underlies quercetin-induced cell death.	Quercetin	165-174	transient receptor potential cation channel subfamily M member 7	Homo sapiens	97-102
24647664-9	2014	Furthermore, treatment with quercetin increased the apoptosis of HEK293 cells, which overexpress TRPM7, indicating that the upregulation of TRPM7 channels underlies quercetin-induced cell death.	Quercetin	165-174	transient receptor potential cation channel subfamily M member 7	Homo sapiens	140-145
24647664-10	2014	These results suggest that quercetin plays an important pathophysiological role in AGS cells through mitogen-activated protein kinase (MAPK) signaling pathways and TRPM7 channels, and that quercetin has potential as a pharmacological agent for the treatment of gastric cancer.	Quercetin	27-36	mitogen-activated protein kinase 1	Homo sapiens	135-139
24647664-10	2014	These results suggest that quercetin plays an important pathophysiological role in AGS cells through mitogen-activated protein kinase (MAPK) signaling pathways and TRPM7 channels, and that quercetin has potential as a pharmacological agent for the treatment of gastric cancer.	Quercetin	27-36	transient receptor potential cation channel subfamily M member 7	Homo sapiens	164-169
24647664-10	2014	These results suggest that quercetin plays an important pathophysiological role in AGS cells through mitogen-activated protein kinase (MAPK) signaling pathways and TRPM7 channels, and that quercetin has potential as a pharmacological agent for the treatment of gastric cancer.	Quercetin	189-198	transient receptor potential cation channel subfamily M member 7	Homo sapiens	164-169
25244766-3	2014	Quercetin with the concentrations of 82.78, 41.39, 20.70 micromol x L(-1) could notably inhibit the increase of TNF-alpha and IL-1beta induced by LPS 100 microg x L(-1) for 3 h and then ATP 5 mmol x L(-1) for 36 h (P &lt; 0.01 or P &lt; 0.05).	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	112-121
24613711-7	2014	RESULTS: Phloretin, quercetin, or PIH significantly prevented the increase in serum ALT, AST, gamma-GT, ALP, and TB in acute liver damage induced by D-GalN, and produced a marked reduction in the histopathological hepatic lesions.	Quercetin	20-29	glutamic pyruvic transaminase, soluble	Mus musculus	84-87
24613711-7	2014	RESULTS: Phloretin, quercetin, or PIH significantly prevented the increase in serum ALT, AST, gamma-GT, ALP, and TB in acute liver damage induced by D-GalN, and produced a marked reduction in the histopathological hepatic lesions.	Quercetin	20-29	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	89-92
24613711-7	2014	RESULTS: Phloretin, quercetin, or PIH significantly prevented the increase in serum ALT, AST, gamma-GT, ALP, and TB in acute liver damage induced by D-GalN, and produced a marked reduction in the histopathological hepatic lesions.	Quercetin	20-29	galanin and GMAP prepropeptide	Mus musculus	151-155
24746831-0	2014	Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway.	Quercetin	0-9	hepcidin antimicrobial peptide	Mus musculus	63-71
24746831-0	2014	Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway.	Quercetin	0-9	bone morphogenetic protein 6	Mus musculus	84-88
24746831-0	2014	Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway.	Quercetin	0-9	SMAD family member 4	Mus musculus	89-94
24746831-10	2014	In contrast, co-treatment with iron and ethanol, especially exposure of iron alone, activated BMP6/SMAD4 pathway and up-regulated hepcidin expression, which was also normalized by quercetin in vivo.	Quercetin	180-189	SMAD family member 4	Mus musculus	99-104
24746831-10	2014	In contrast, co-treatment with iron and ethanol, especially exposure of iron alone, activated BMP6/SMAD4 pathway and up-regulated hepcidin expression, which was also normalized by quercetin in vivo.	Quercetin	180-189	hepcidin antimicrobial peptide	Mus musculus	130-138
24746831-11	2014	Quercetin prevented ethanol-induced hepatic iron overload different from what carbonyl iron diet elicited in the mechanism, by regulating hepcidin expression via the BMP6/SMAD4 signaling pathway.	Quercetin	0-9	hepcidin antimicrobial peptide	Mus musculus	138-146
24746831-11	2014	Quercetin prevented ethanol-induced hepatic iron overload different from what carbonyl iron diet elicited in the mechanism, by regulating hepcidin expression via the BMP6/SMAD4 signaling pathway.	Quercetin	0-9	bone morphogenetic protein 6	Mus musculus	166-170
24746831-11	2014	Quercetin prevented ethanol-induced hepatic iron overload different from what carbonyl iron diet elicited in the mechanism, by regulating hepcidin expression via the BMP6/SMAD4 signaling pathway.	Quercetin	0-9	SMAD family member 4	Mus musculus	171-176
24038588-3	2014	The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin-6 and interferon-gamma in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated-STAT1 and STAT3 proteins in a dose-dependent manner.	Quercetin	168-177	interleukin 6	Homo sapiens	84-97
24038588-3	2014	The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin-6 and interferon-gamma in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated-STAT1 and STAT3 proteins in a dose-dependent manner.	Quercetin	168-177	interferon gamma	Homo sapiens	102-118
24038588-3	2014	The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin-6 and interferon-gamma in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated-STAT1 and STAT3 proteins in a dose-dependent manner.	Quercetin	168-177	signal transducer and activator of transcription 1	Homo sapiens	243-248
24038588-3	2014	The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin-6 and interferon-gamma in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated-STAT1 and STAT3 proteins in a dose-dependent manner.	Quercetin	168-177	signal transducer and activator of transcription 3	Homo sapiens	253-258
24038588-4	2014	The cytokine-mediated up-regulation of inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule-1 (ICAM-1) via JAK/STAT cascade was abolished by both quercetin and EGCG pretreatment.	Quercetin	168-177	nitric oxide synthase 2	Homo sapiens	39-70
24038588-4	2014	The cytokine-mediated up-regulation of inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule-1 (ICAM-1) via JAK/STAT cascade was abolished by both quercetin and EGCG pretreatment.	Quercetin	168-177	nitric oxide synthase 2	Homo sapiens	72-76
24038588-4	2014	The cytokine-mediated up-regulation of inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule-1 (ICAM-1) via JAK/STAT cascade was abolished by both quercetin and EGCG pretreatment.	Quercetin	168-177	intercellular adhesion molecule 1	Homo sapiens	82-115
24038588-4	2014	The cytokine-mediated up-regulation of inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule-1 (ICAM-1) via JAK/STAT cascade was abolished by both quercetin and EGCG pretreatment.	Quercetin	168-177	intercellular adhesion molecule 1	Homo sapiens	117-123
25244766-3	2014	Quercetin with the concentrations of 82.78, 41.39, 20.70 micromol x L(-1) could notably inhibit the increase of TNF-alpha and IL-1beta induced by LPS 100 microg x L(-1) for 3 h and then ATP 5 mmol x L(-1) for 36 h (P &lt; 0.01 or P &lt; 0.05).	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	126-134
25244766-4	2014	Quercetin with the concentrations of 82.78, 41.39 micromol x L(-1) could notably inhibit the increase of IL-6 induced LPS 100 microg x L(-1) for 3 h and then ATP 5 mmol x L(-1) for 36 h (P &lt; 0.05), without any notable effect of quercetin with the concentration of 20.70 micromol x L(-1).	Quercetin	0-9	interleukin 6	Rattus norvegicus	105-109
25244766-4	2014	Quercetin with the concentrations of 82.78, 41.39 micromol x L(-1) could notably inhibit the increase of IL-6 induced LPS 100 microg x L(-1) for 3 h and then ATP 5 mmol x L(-1) for 36 h (P &lt; 0.05), without any notable effect of quercetin with the concentration of 20.70 micromol x L(-1).	Quercetin	231-240	interleukin 6	Rattus norvegicus	105-109
25244766-8	2014	Therefore, this study believes that quercetin could attenuate the secretion of inflammatory factors TNF-alpha, IL-1beta and IL-6 of cardiac fibroblasts by inhibiting the activation of NF-kappaB p65 (S276) and Akt (473).	Quercetin	36-45	tumor necrosis factor	Rattus norvegicus	100-109
25244766-8	2014	Therefore, this study believes that quercetin could attenuate the secretion of inflammatory factors TNF-alpha, IL-1beta and IL-6 of cardiac fibroblasts by inhibiting the activation of NF-kappaB p65 (S276) and Akt (473).	Quercetin	36-45	interleukin 1 beta	Rattus norvegicus	111-119
25244766-8	2014	Therefore, this study believes that quercetin could attenuate the secretion of inflammatory factors TNF-alpha, IL-1beta and IL-6 of cardiac fibroblasts by inhibiting the activation of NF-kappaB p65 (S276) and Akt (473).	Quercetin	36-45	interleukin 6	Rattus norvegicus	124-128
25244766-8	2014	Therefore, this study believes that quercetin could attenuate the secretion of inflammatory factors TNF-alpha, IL-1beta and IL-6 of cardiac fibroblasts by inhibiting the activation of NF-kappaB p65 (S276) and Akt (473).	Quercetin	36-45	synaptotagmin 1	Rattus norvegicus	194-197
24612139-0	2014	Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway.	Quercetin	0-9	DNA damage inducible transcript 3	Homo sapiens	174-223
24859282-0	2014	Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter niemann-pick c1-like 1 in caco-2 cells and rats.	Quercetin	13-22	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	104-126
24859282-8	2014	Luteolin and quercetin inhibited cholesterol absorption by Caco-2 cells and human embryonic kidney 293T cells expressing NPC1L1.	Quercetin	13-22	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	121-127
24859282-13	2014	As quercetin induced a significant decrease in the levels of NPC1L1 mRNA in Caco-2 cells, the in vivo inhibitory effect may be due to the expression of NPC1L1.	Quercetin	3-12	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	61-67
24859282-13	2014	As quercetin induced a significant decrease in the levels of NPC1L1 mRNA in Caco-2 cells, the in vivo inhibitory effect may be due to the expression of NPC1L1.	Quercetin	3-12	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	152-158
24859282-14	2014	These results suggest that luteolin and quercetin reduce high blood cholesterol levels by specifically inhibiting intestinal cholesterol absorption mediated by NPC1L1.	Quercetin	40-49	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	160-166
25191605-4	2014	Quercetin and licorice extract exhibited bone formation activity as measured by bone morphogenetic protein-2 (BMP-2) promoter activation, increased expression of BMP-2 mRNA and protein levels, and promotion of bone growth in cultured mouse calvariae.	Quercetin	0-9	bone morphogenetic protein 2	Mus musculus	80-108
25191605-4	2014	Quercetin and licorice extract exhibited bone formation activity as measured by bone morphogenetic protein-2 (BMP-2) promoter activation, increased expression of BMP-2 mRNA and protein levels, and promotion of bone growth in cultured mouse calvariae.	Quercetin	0-9	bone morphogenetic protein 2	Mus musculus	110-115
25191605-4	2014	Quercetin and licorice extract exhibited bone formation activity as measured by bone morphogenetic protein-2 (BMP-2) promoter activation, increased expression of BMP-2 mRNA and protein levels, and promotion of bone growth in cultured mouse calvariae.	Quercetin	0-9	bone morphogenetic protein 2	Mus musculus	162-167
24727240-6	2014	KEY FINDINGS: The quercetin promoted earlier locomotor recovery, suggesting that there was demyelination prevention or further remyelination velocity as well as it was able to prevent the inhibition of AChE activity and the increase of lipidic peroxidation, suggesting that this compound can protect cholinergic neurotransmission.	Quercetin	18-27	acetylcholinesterase	Rattus norvegicus	202-206
24705122-0	2014	The role of AMP-activated protein kinase in quercetin-induced apoptosis of HL-60 cells.	Quercetin	44-53	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	12-40
24705122-1	2014	Our previous studies have shown that quercetin inhibits Cox-2 and Bcl-2 expressions, and induces human leukemia HL-60 cell apoptosis.	Quercetin	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
24705122-1	2014	Our previous studies have shown that quercetin inhibits Cox-2 and Bcl-2 expressions, and induces human leukemia HL-60 cell apoptosis.	Quercetin	37-46	BCL2 apoptosis regulator	Homo sapiens	66-71
24705122-2	2014	In order to investigate the role of AMP-activated protein kinase (AMPK) on quercetin-induced apoptosis of HL-60 cells, we used flow cytometry to detect cell apoptosis.	Quercetin	75-84	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	36-64
24705122-2	2014	In order to investigate the role of AMP-activated protein kinase (AMPK) on quercetin-induced apoptosis of HL-60 cells, we used flow cytometry to detect cell apoptosis.	Quercetin	75-84	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	66-70
24705122-4	2014	The expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin.	Quercetin	91-100	serine/threonine kinase 11	Homo sapiens	19-23
24705122-4	2014	The expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin.	Quercetin	91-100	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	27-31
24705122-4	2014	The expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin.	Quercetin	91-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
24705122-5	2014	The expressions of p-AMPK were detected in HL-60 cells after culture with AMPK inhibitor Compound C. Then, the expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin alone or quercetin + Compound C. It was found that there was no significant difference in LKB1 between PBMCs and HL-60.	Quercetin	198-207	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	21-25
24705122-5	2014	The expressions of p-AMPK were detected in HL-60 cells after culture with AMPK inhibitor Compound C. Then, the expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin alone or quercetin + Compound C. It was found that there was no significant difference in LKB1 between PBMCs and HL-60.	Quercetin	198-207	serine/threonine kinase 11	Homo sapiens	126-130
24705122-5	2014	The expressions of p-AMPK were detected in HL-60 cells after culture with AMPK inhibitor Compound C. Then, the expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin alone or quercetin + Compound C. It was found that there was no significant difference in LKB1 between PBMCs and HL-60.	Quercetin	198-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
24705122-5	2014	The expressions of p-AMPK were detected in HL-60 cells after culture with AMPK inhibitor Compound C. Then, the expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin alone or quercetin + Compound C. It was found that there was no significant difference in LKB1 between PBMCs and HL-60.	Quercetin	217-226	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	21-25
24705122-5	2014	The expressions of p-AMPK were detected in HL-60 cells after culture with AMPK inhibitor Compound C. Then, the expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin alone or quercetin + Compound C. It was found that there was no significant difference in LKB1 between PBMCs and HL-60.	Quercetin	217-226	serine/threonine kinase 11	Homo sapiens	126-130
24705122-5	2014	The expressions of p-AMPK were detected in HL-60 cells after culture with AMPK inhibitor Compound C. Then, the expressions of LKB1, p-AMPK, and Cox-2 were detected in HL-60 cells after culture with quercetin alone or quercetin + Compound C. It was found that there was no significant difference in LKB1 between PBMCs and HL-60.	Quercetin	217-226	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	144-149
24705122-7	2014	After culture of HL-60 with quercetin, p-AMPK was increased, Cox-2 was decreased, but LKB1 remained unchanged.	Quercetin	28-37	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	41-45
24705122-7	2014	After culture of HL-60 with quercetin, p-AMPK was increased, Cox-2 was decreased, but LKB1 remained unchanged.	Quercetin	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
24705122-7	2014	After culture of HL-60 with quercetin, p-AMPK was increased, Cox-2 was decreased, but LKB1 remained unchanged.	Quercetin	28-37	serine/threonine kinase 11	Homo sapiens	86-90
24705122-10	2014	p-AMPK decreased more significantly, while Cox-2 increased more significantly in the quercetin + Compound C groups than those in the quercetin-alone groups.	Quercetin	85-94	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	2-6
24705122-10	2014	p-AMPK decreased more significantly, while Cox-2 increased more significantly in the quercetin + Compound C groups than those in the quercetin-alone groups.	Quercetin	85-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
24705122-11	2014	Taken together, these findings suggested that quercetin activates AMPK expression in HL-60 cells independent of LKB1 activation, inhibits Cox-2 expression by activating AMPK, and further regulates the Bcl-2-dependent pathways of apoptosis to exert its anti-leukemia effect.	Quercetin	46-55	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	66-70
24705122-11	2014	Taken together, these findings suggested that quercetin activates AMPK expression in HL-60 cells independent of LKB1 activation, inhibits Cox-2 expression by activating AMPK, and further regulates the Bcl-2-dependent pathways of apoptosis to exert its anti-leukemia effect.	Quercetin	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
24705122-11	2014	Taken together, these findings suggested that quercetin activates AMPK expression in HL-60 cells independent of LKB1 activation, inhibits Cox-2 expression by activating AMPK, and further regulates the Bcl-2-dependent pathways of apoptosis to exert its anti-leukemia effect.	Quercetin	46-55	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	169-173
24705122-11	2014	Taken together, these findings suggested that quercetin activates AMPK expression in HL-60 cells independent of LKB1 activation, inhibits Cox-2 expression by activating AMPK, and further regulates the Bcl-2-dependent pathways of apoptosis to exert its anti-leukemia effect.	Quercetin	46-55	BCL2 apoptosis regulator	Homo sapiens	201-206
24612139-0	2014	Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	39-94
24612139-0	2014	Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	96-101
24612139-0	2014	Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway.	Quercetin	0-9	DNA damage inducible transcript 3	Homo sapiens	225-229
24612139-2	2014	We investigated whether quercetin, a flavonoid, can sensitize human ovarian cancer cells to TRAIL.	Quercetin	24-33	TNF superfamily member 10	Homo sapiens	92-97
24612139-3	2014	Results indicate that quercetin sensitized cancer cells to TRAIL.	Quercetin	22-31	TNF superfamily member 10	Homo sapiens	59-64
24612139-4	2014	The quercetin induced expression of death receptor DR5 but did not affect expression of DR4 in cancer cells.	Quercetin	4-13	TNF receptor superfamily member 10b	Homo sapiens	51-54
24612139-5	2014	The induction of DR5 was mediated through activation of JNK and through upregulation of a transcription factor CCAAT enhancer-binding protein homologous protein (CHOP); as silencing of these signaling molecules abrogated the effect of quercetin.	Quercetin	235-244	TNF receptor superfamily member 10b	Homo sapiens	17-20
24612139-5	2014	The induction of DR5 was mediated through activation of JNK and through upregulation of a transcription factor CCAAT enhancer-binding protein homologous protein (CHOP); as silencing of these signaling molecules abrogated the effect of quercetin.	Quercetin	235-244	DNA damage inducible transcript 3	Homo sapiens	111-160
24612139-5	2014	The induction of DR5 was mediated through activation of JNK and through upregulation of a transcription factor CCAAT enhancer-binding protein homologous protein (CHOP); as silencing of these signaling molecules abrogated the effect of quercetin.	Quercetin	235-244	DNA damage inducible transcript 3	Homo sapiens	162-166
24612139-6	2014	Upregulation of DR5 was mediated through the generation of reactive oxygen species (ROS), as ROS scavengers reduced the effect of quercetin on JNK activation, CHOP upregulation, DR induction, TRAIL sensitization, downregulated the expression of cell survival proteins and upregulated the proapoptotic proteins.	Quercetin	130-139	TNF receptor superfamily member 10b	Homo sapiens	16-19
24612139-6	2014	Upregulation of DR5 was mediated through the generation of reactive oxygen species (ROS), as ROS scavengers reduced the effect of quercetin on JNK activation, CHOP upregulation, DR induction, TRAIL sensitization, downregulated the expression of cell survival proteins and upregulated the proapoptotic proteins.	Quercetin	130-139	mitogen-activated protein kinase 8	Homo sapiens	143-146
24612139-6	2014	Upregulation of DR5 was mediated through the generation of reactive oxygen species (ROS), as ROS scavengers reduced the effect of quercetin on JNK activation, CHOP upregulation, DR induction, TRAIL sensitization, downregulated the expression of cell survival proteins and upregulated the proapoptotic proteins.	Quercetin	130-139	DNA damage inducible transcript 3	Homo sapiens	159-163
24612139-7	2014	Furthermore, quercetin enhances TRAIL mediated inhibition of tumor growth of human SKOV-3 xenograft was associated with induction of apoptosis, activation of caspase-3, CHOP and DR5.	Quercetin	13-22	TNF superfamily member 10	Homo sapiens	32-37
24612139-7	2014	Furthermore, quercetin enhances TRAIL mediated inhibition of tumor growth of human SKOV-3 xenograft was associated with induction of apoptosis, activation of caspase-3, CHOP and DR5.	Quercetin	13-22	caspase 3	Homo sapiens	158-167
24612139-7	2014	Furthermore, quercetin enhances TRAIL mediated inhibition of tumor growth of human SKOV-3 xenograft was associated with induction of apoptosis, activation of caspase-3, CHOP and DR5.	Quercetin	13-22	DNA damage inducible transcript 3	Homo sapiens	169-173
24612139-7	2014	Furthermore, quercetin enhances TRAIL mediated inhibition of tumor growth of human SKOV-3 xenograft was associated with induction of apoptosis, activation of caspase-3, CHOP and DR5.	Quercetin	13-22	TNF receptor superfamily member 10b	Homo sapiens	178-181
24612139-8	2014	Overall, our data suggest that quercetin enhances apoptotic death of ovarian cancer cells to TRAIL through upregulation of CHOP-induced DR5 expression following ROS mediated endoplasmic reticulum-stress.	Quercetin	31-40	TNF superfamily member 10	Homo sapiens	93-98
24612139-8	2014	Overall, our data suggest that quercetin enhances apoptotic death of ovarian cancer cells to TRAIL through upregulation of CHOP-induced DR5 expression following ROS mediated endoplasmic reticulum-stress.	Quercetin	31-40	DNA damage inducible transcript 3	Homo sapiens	123-127
24612139-8	2014	Overall, our data suggest that quercetin enhances apoptotic death of ovarian cancer cells to TRAIL through upregulation of CHOP-induced DR5 expression following ROS mediated endoplasmic reticulum-stress.	Quercetin	31-40	TNF receptor superfamily member 10b	Homo sapiens	136-139
24325454-0	2014	Quercetin suppresses MIP-1alpha-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling.	Quercetin	0-9	C-C motif chemokine ligand 3	Homo sapiens	21-31
24569067-8	2014	The expressions of divalent metal transporter 1, zinc transporter member 14, mucolipin 1, transferrin receptor 1 (TfR1) and ferritin were up-regulated by ethanol and/or iron, which were partially normalized by quercetin.	Quercetin	210-219	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	Mus musculus	19-88
24569067-8	2014	The expressions of divalent metal transporter 1, zinc transporter member 14, mucolipin 1, transferrin receptor 1 (TfR1) and ferritin were up-regulated by ethanol and/or iron, which were partially normalized by quercetin.	Quercetin	210-219	transferrin receptor	Mus musculus	90-112
24569067-8	2014	The expressions of divalent metal transporter 1, zinc transporter member 14, mucolipin 1, transferrin receptor 1 (TfR1) and ferritin were up-regulated by ethanol and/or iron, which were partially normalized by quercetin.	Quercetin	210-219	transferrin receptor	Mus musculus	114-118
24325454-0	2014	Quercetin suppresses MIP-1alpha-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling.	Quercetin	0-9	C-C motif chemokine receptor 1	Homo sapiens	93-97
24325454-0	2014	Quercetin suppresses MIP-1alpha-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling.	Quercetin	0-9	C-C motif chemokine receptor 5	Homo sapiens	98-102
24325454-4	2014	Here we demonstrate that quercetin decreases MIP-1alpha release from adipocytes and macrophages and from cocultured adipocytes/macrophages; it also opposes MIP-1alpha-induced macrophage infiltration and activation.	Quercetin	25-34	C-C motif chemokine ligand 3	Homo sapiens	45-55
24325454-4	2014	Here we demonstrate that quercetin decreases MIP-1alpha release from adipocytes and macrophages and from cocultured adipocytes/macrophages; it also opposes MIP-1alpha-induced macrophage infiltration and activation.	Quercetin	25-34	C-C motif chemokine ligand 3	Homo sapiens	156-166
24325454-5	2014	The inhibitory action of quercetin on the MIP-1alpha-induced inflammatory responses of macrophages is mediated by downregulation of CCR1/CCR5, and inhibition of activation of JNK, p38 mitogen-activated-protein kinase (MAPK), and IKK as well as IkappaBalpha degradation.	Quercetin	25-34	C-C motif chemokine ligand 3	Homo sapiens	42-52
24325454-5	2014	The inhibitory action of quercetin on the MIP-1alpha-induced inflammatory responses of macrophages is mediated by downregulation of CCR1/CCR5, and inhibition of activation of JNK, p38 mitogen-activated-protein kinase (MAPK), and IKK as well as IkappaBalpha degradation.	Quercetin	25-34	C-C motif chemokine receptor 1	Homo sapiens	132-136
24325454-5	2014	The inhibitory action of quercetin on the MIP-1alpha-induced inflammatory responses of macrophages is mediated by downregulation of CCR1/CCR5, and inhibition of activation of JNK, p38 mitogen-activated-protein kinase (MAPK), and IKK as well as IkappaBalpha degradation.	Quercetin	25-34	C-C motif chemokine receptor 5	Homo sapiens	137-141
24325454-5	2014	The inhibitory action of quercetin on the MIP-1alpha-induced inflammatory responses of macrophages is mediated by downregulation of CCR1/CCR5, and inhibition of activation of JNK, p38 mitogen-activated-protein kinase (MAPK), and IKK as well as IkappaBalpha degradation.	Quercetin	25-34	mitogen-activated protein kinase 14	Homo sapiens	180-216
24325454-5	2014	The inhibitory action of quercetin on the MIP-1alpha-induced inflammatory responses of macrophages is mediated by downregulation of CCR1/CCR5, and inhibition of activation of JNK, p38 mitogen-activated-protein kinase (MAPK), and IKK as well as IkappaBalpha degradation.	Quercetin	25-34	NFKB inhibitor alpha	Homo sapiens	244-256
24407905-0	2014	The polyphenol quercetin protects the mev-1 mutant of Caenorhabditis elegans from glucose-induced reduction of survival under heat-stress depending on SIR-2.1, DAF-12, and proteasomal activity.	Quercetin	15-24	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	38-43
24343960-0	2014	Quercetin differently regulates insulin-mediated glucose transporter 4 translocation under basal and inflammatory conditions in adipocytes.	Quercetin	0-9	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	49-70
24343960-2	2014	This study aims to investigate the effects of quercetin on insulin-mediated glucose transporter 4 (GLUT4) translocation under basal and inflammatory conditions as well as the molecular mechanisms in adipocytes.	Quercetin	46-55	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	76-97
24407905-0	2014	The polyphenol quercetin protects the mev-1 mutant of Caenorhabditis elegans from glucose-induced reduction of survival under heat-stress depending on SIR-2.1, DAF-12, and proteasomal activity.	Quercetin	15-24	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	151-158
24343960-2	2014	This study aims to investigate the effects of quercetin on insulin-mediated glucose transporter 4 (GLUT4) translocation under basal and inflammatory conditions as well as the molecular mechanisms in adipocytes.	Quercetin	46-55	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	99-104
24343960-3	2014	METHODS AND RESULTS: The effects of quercetin on insulin-mediated GLUT4 translocation in 3T3-L1 cells under basal and insulin resistant conditions were investigated.	Quercetin	36-45	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	66-71
24343960-5	2014	Quercetin inhibited insulin-mediated GLUT4 translocation by inhibiting AS160 phosphorylation.	Quercetin	0-9	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	37-42
24343960-5	2014	Quercetin inhibited insulin-mediated GLUT4 translocation by inhibiting AS160 phosphorylation.	Quercetin	0-9	TBC1 domain family, member 4	Mus musculus	71-76
24343960-6	2014	Differently, when inflammatory challenge impaired insulin action in 3T3-L1 cells, quercetin inhibited IkappaB kinase beta (IKKbeta) phosphorylation and facilitated insulin signaling, leading to the restoration of insulin-mediated AS160 phosphorylation and downstream GLUT4 translocation.	Quercetin	82-91	inhibitor of kappaB kinase beta	Mus musculus	102-121
24343960-6	2014	Differently, when inflammatory challenge impaired insulin action in 3T3-L1 cells, quercetin inhibited IkappaB kinase beta (IKKbeta) phosphorylation and facilitated insulin signaling, leading to the restoration of insulin-mediated AS160 phosphorylation and downstream GLUT4 translocation.	Quercetin	82-91	inhibitor of kappaB kinase beta	Mus musculus	123-130
24407905-0	2014	The polyphenol quercetin protects the mev-1 mutant of Caenorhabditis elegans from glucose-induced reduction of survival under heat-stress depending on SIR-2.1, DAF-12, and proteasomal activity.	Quercetin	15-24	Nuclear hormone receptor family member daf-12	Caenorhabditis elegans	160-166
24343960-6	2014	Differently, when inflammatory challenge impaired insulin action in 3T3-L1 cells, quercetin inhibited IkappaB kinase beta (IKKbeta) phosphorylation and facilitated insulin signaling, leading to the restoration of insulin-mediated AS160 phosphorylation and downstream GLUT4 translocation.	Quercetin	82-91	TBC1 domain family, member 4	Mus musculus	230-235
24343960-6	2014	Differently, when inflammatory challenge impaired insulin action in 3T3-L1 cells, quercetin inhibited IkappaB kinase beta (IKKbeta) phosphorylation and facilitated insulin signaling, leading to the restoration of insulin-mediated AS160 phosphorylation and downstream GLUT4 translocation.	Quercetin	82-91	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	267-272
24343960-9	2014	CONCLUSION: Quercetin demonstrated divergent effects on insulin-mediated GLUT4 translocation in adipocytes under basal and insulin resistant conditions, which were related to its regulation of AMPK activity.	Quercetin	12-21	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	73-78
24407905-4	2014	RNA interference revealed that the sirtuin SIR-2.1, the nuclear hormone receptor DAF-12, and its putative co-activator MDT-15 were critical for the quercetin effects.	Quercetin	148-157	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	43-50
24407905-4	2014	RNA interference revealed that the sirtuin SIR-2.1, the nuclear hormone receptor DAF-12, and its putative co-activator MDT-15 were critical for the quercetin effects.	Quercetin	148-157	Nuclear hormone receptor family member daf-12	Caenorhabditis elegans	81-87
24407905-4	2014	RNA interference revealed that the sirtuin SIR-2.1, the nuclear hormone receptor DAF-12, and its putative co-activator MDT-15 were critical for the quercetin effects.	Quercetin	148-157	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	119-125
24951996-8	2014	CAT and GPx decreased in PCBs and increased when quercetin was added.	Quercetin	49-58	catalase	Rattus norvegicus	0-3
25151738-5	2014	The mechanism of quercetin enhancing ability of retinoic acid on the induction of RARbeta, activating TPO, using as COX-2 and PDEs inhibitor was approved by biomolecular network and related literatures.	Quercetin	17-26	retinoic acid receptor, beta	Rattus norvegicus	82-89
24720993-6	2014	It was found that flavonols (quercetin and myricetin) and flavans (epicatechin gallate (ECG) and epigallocatechin (EGC)) showed higher TOD inhibitory activity than flavones and flavanones.	Quercetin	29-38	monoamine oxidase B	Homo sapiens	135-138
24849437-0	2014	[Effect of quercetin on glioma cell U87 apoptosis and feedback regulation of MDM2-p53].	Quercetin	11-20	MDM2 proto-oncogene	Homo sapiens	77-81
24849437-0	2014	[Effect of quercetin on glioma cell U87 apoptosis and feedback regulation of MDM2-p53].	Quercetin	11-20	tumor protein p53	Homo sapiens	82-85
24849437-1	2014	OBJECTIVE: To investigate the effect of quercetin on apoptosis and feedback regulation of MDM2-p53 in multiform glioblastoma U87 cells in vitro.	Quercetin	40-49	MDM2 proto-oncogene	Homo sapiens	90-94
24849437-1	2014	OBJECTIVE: To investigate the effect of quercetin on apoptosis and feedback regulation of MDM2-p53 in multiform glioblastoma U87 cells in vitro.	Quercetin	40-49	tumor protein p53	Homo sapiens	95-98
24849437-2	2014	METHODS: U87 cells exposed to different concentrations of quercetin (50, 100, and 150 micromol/L) were examined with flow cytometry, RT-PCR and Western blotting for detecting the cell apoptosis, MDM2 mRNA expression, and p53 and caspase-3 expressions.	Quercetin	58-67	MDM2 proto-oncogene	Homo sapiens	195-199
24849437-2	2014	METHODS: U87 cells exposed to different concentrations of quercetin (50, 100, and 150 micromol/L) were examined with flow cytometry, RT-PCR and Western blotting for detecting the cell apoptosis, MDM2 mRNA expression, and p53 and caspase-3 expressions.	Quercetin	58-67	tumor protein p53	Homo sapiens	221-224
24849437-2	2014	METHODS: U87 cells exposed to different concentrations of quercetin (50, 100, and 150 micromol/L) were examined with flow cytometry, RT-PCR and Western blotting for detecting the cell apoptosis, MDM2 mRNA expression, and p53 and caspase-3 expressions.	Quercetin	58-67	caspase 3	Homo sapiens	229-238
24849437-4	2014	Quercetin significantly increased the expressions of MDM2 mRNA and active caspase-3 protein but decreased the expression of p53 in the cells.	Quercetin	0-9	MDM2 proto-oncogene	Homo sapiens	53-57
25151738-5	2014	The mechanism of quercetin enhancing ability of retinoic acid on the induction of RARbeta, activating TPO, using as COX-2 and PDEs inhibitor was approved by biomolecular network and related literatures.	Quercetin	17-26	thyroid peroxidase	Rattus norvegicus	102-105
24849437-4	2014	Quercetin significantly increased the expressions of MDM2 mRNA and active caspase-3 protein but decreased the expression of p53 in the cells.	Quercetin	0-9	caspase 3	Homo sapiens	74-83
24849437-4	2014	Quercetin significantly increased the expressions of MDM2 mRNA and active caspase-3 protein but decreased the expression of p53 in the cells.	Quercetin	0-9	tumor protein p53	Homo sapiens	124-127
25151738-5	2014	The mechanism of quercetin enhancing ability of retinoic acid on the induction of RARbeta, activating TPO, using as COX-2 and PDEs inhibitor was approved by biomolecular network and related literatures.	Quercetin	17-26	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	116-121
24849437-5	2014	CONCLUSION: Quercetin promotes the apoptosis of multiform glioblastoma U87 cells mediated by caspase-3 and influences the feedback balance of MDM2-p53.	Quercetin	12-21	caspase 3	Homo sapiens	93-102
24849437-5	2014	CONCLUSION: Quercetin promotes the apoptosis of multiform glioblastoma U87 cells mediated by caspase-3 and influences the feedback balance of MDM2-p53.	Quercetin	12-21	MDM2 proto-oncogene	Homo sapiens	142-146
24705271-7	2014	Dark-grown prn1 mutant seedlings produced more quercetin after UV (317 nm) induction, compared to levels observed in wild type (WT) seedlings.	Quercetin	47-56	pirin	Arabidopsis thaliana	11-15
24849437-5	2014	CONCLUSION: Quercetin promotes the apoptosis of multiform glioblastoma U87 cells mediated by caspase-3 and influences the feedback balance of MDM2-p53.	Quercetin	12-21	tumor protein p53	Homo sapiens	147-150
24705271-0	2014	Pirin1 (PRN1) is a multifunctional protein that regulates quercetin, and impacts specific light and UV responses in the seed-to-seedling transition of Arabidopsis thaliana.	Quercetin	58-67	pirin	Arabidopsis thaliana	0-6
24705271-0	2014	Pirin1 (PRN1) is a multifunctional protein that regulates quercetin, and impacts specific light and UV responses in the seed-to-seedling transition of Arabidopsis thaliana.	Quercetin	58-67	pirin	Arabidopsis thaliana	8-12
24705271-13	2014	PRN1 may play a critical role in cellular quercetin levels and influence light- or hormonal-directed early development.	Quercetin	42-51	pirin	Arabidopsis thaliana	0-4
22431435-8	2014	Western blotting analysis indicated that quercetin induces the G0/G1 phase arrest via decreasing the levels of CDK2, cyclins E, and D proteins.	Quercetin	41-50	cyclin dependent kinase 2	Homo sapiens	111-115
24617900-7	2014	Results of qPCR indicated that quercetin promoted expressions of Osx, Runx2, BMP-2, Col-1, OPN and OCN at the mRNA level in the presence of osteo-induction medium.	Quercetin	31-40	Sp7 transcription factor 7	Mus musculus	65-68
24617900-7	2014	Results of qPCR indicated that quercetin promoted expressions of Osx, Runx2, BMP-2, Col-1, OPN and OCN at the mRNA level in the presence of osteo-induction medium.	Quercetin	31-40	runt related transcription factor 2	Mus musculus	70-75
24617900-7	2014	Results of qPCR indicated that quercetin promoted expressions of Osx, Runx2, BMP-2, Col-1, OPN and OCN at the mRNA level in the presence of osteo-induction medium.	Quercetin	31-40	bone morphogenetic protein 2	Mus musculus	77-82
24617900-7	2014	Results of qPCR indicated that quercetin promoted expressions of Osx, Runx2, BMP-2, Col-1, OPN and OCN at the mRNA level in the presence of osteo-induction medium.	Quercetin	31-40	secreted phosphoprotein 1	Mus musculus	91-94
24617900-8	2014	CONCLUSIONS: Our data demonstrated that quercetin was not active in terms of enhancing mASCs proliferation; however, it increased osteogenesis of mASCs by up-regulation of genes including Osx, Runx2, BMP-2, Col-1, OPN and OCN.	Quercetin	40-49	Sp7 transcription factor 7	Mus musculus	188-191
24617900-8	2014	CONCLUSIONS: Our data demonstrated that quercetin was not active in terms of enhancing mASCs proliferation; however, it increased osteogenesis of mASCs by up-regulation of genes including Osx, Runx2, BMP-2, Col-1, OPN and OCN.	Quercetin	40-49	runt related transcription factor 2	Mus musculus	193-198
24617900-8	2014	CONCLUSIONS: Our data demonstrated that quercetin was not active in terms of enhancing mASCs proliferation; however, it increased osteogenesis of mASCs by up-regulation of genes including Osx, Runx2, BMP-2, Col-1, OPN and OCN.	Quercetin	40-49	bone morphogenetic protein 2	Mus musculus	200-205
22431435-9	2014	Quercetin also stimulated the protein expression of ATF, GRP78, and GADD153 which is a hall marker of ER stress.	Quercetin	0-9	glial cell derived neurotrophic factor	Homo sapiens	52-55
22431435-9	2014	Quercetin also stimulated the protein expression of ATF, GRP78, and GADD153 which is a hall marker of ER stress.	Quercetin	0-9	heat shock protein family A (Hsp70) member 5	Homo sapiens	57-62
22431435-9	2014	Quercetin also stimulated the protein expression of ATF, GRP78, and GADD153 which is a hall marker of ER stress.	Quercetin	0-9	DNA damage inducible transcript 3	Homo sapiens	68-75
24491314-12	2014	These results provide in vivo evidence that quercetin-mediated down-regulation of AMPK/TXNIP and subsequent inhibition of NF-kappaB pathway/NLRP3 inflammasome activation in the hypothalamus of rats may be associated with the reduction of hypothalamic inflammatory lesions, contributing to the improvement of hypothalamic insulin signaling defect in this model.	Quercetin	44-53	thioredoxin interacting protein	Rattus norvegicus	87-92
24447974-6	2014	In the present study, we have evaluated the effects of quercetin on the expression of other thyroid-restricted genes, and we show that quercetin decreases the expression of the thyrotropin receptor, thyroid peroxidase and thyroglobulin genes.	Quercetin	135-144	thyroid stimulating hormone receptor	Rattus norvegicus	177-197
24535669-0	2014	Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.	Quercetin	0-9	sestrin 2	Homo sapiens	24-33
24535669-0	2014	Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	39-42
24535669-0	2014	Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.	Quercetin	0-9	tumor protein p53	Homo sapiens	143-146
24535669-2	2014	In the present study, we investigated the regulatory mechanisms responsible for quercetin-induced apoptosis, mamely the increased expression of sestrin 2 and the activation of the 5" AMP-activated protein kinase (AMPK)/p38 MAPK signaling pathway.	Quercetin	80-89	sestrin 2	Homo sapiens	144-153
24535669-2	2014	In the present study, we investigated the regulatory mechanisms responsible for quercetin-induced apoptosis, mamely the increased expression of sestrin 2 and the activation of the 5" AMP-activated protein kinase (AMPK)/p38 MAPK signaling pathway.	Quercetin	80-89	mitogen-activated protein kinase 14	Homo sapiens	219-222
24535669-3	2014	Our results revealed that quercetin induced apoptosis by generating the production of intracellular reactive oxygen species (ROS) and increasing the expression of sestrin 2.	Quercetin	26-35	sestrin 2	Homo sapiens	163-172
24535669-4	2014	The induction of apoptosis by quercetin occurred through the activation of the AMPK/p38 signaling pathway and was dependent on sestrin 2.	Quercetin	30-39	mitogen-activated protein kinase 14	Homo sapiens	84-87
24535669-4	2014	The induction of apoptosis by quercetin occurred through the activation of the AMPK/p38 signaling pathway and was dependent on sestrin 2.	Quercetin	30-39	sestrin 2	Homo sapiens	127-136
24535669-7	2014	We demonstrate that the increase in the expression of sestrin 2 by quercetin-generated intracellular ROS is p53-independent.	Quercetin	67-76	sestrin 2	Homo sapiens	54-63
24535669-7	2014	We demonstrate that the increase in the expression of sestrin 2 by quercetin-generated intracellular ROS is p53-independent.	Quercetin	67-76	tumor protein p53	Homo sapiens	108-111
24535669-8	2014	The increased expression of sestrin 2 induced apoptosis through the AMPK/p38 signaling pathway in the HT-29 colon cancer cells, which are p53 mutant, treated with quercetin.	Quercetin	163-172	sestrin 2	Homo sapiens	28-37
24535669-9	2014	Thus, our data suggest that quercetin induces apoptosis by reducing mitochondrial membrane potential, generating intracellular ROS production and increasing sestrin 2 expression through the AMPK/p38 pathway.	Quercetin	28-37	sestrin 2	Homo sapiens	157-166
24535669-9	2014	Thus, our data suggest that quercetin induces apoptosis by reducing mitochondrial membrane potential, generating intracellular ROS production and increasing sestrin 2 expression through the AMPK/p38 pathway.	Quercetin	28-37	mitogen-activated protein kinase 14	Homo sapiens	195-198
24491314-0	2014	Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats.	Quercetin	0-9	thioredoxin interacting protein	Rattus norvegicus	24-29
24491314-4	2014	Quercetin, a natural flavonoid, has been reported to ameliorate high fructose-induced rat insulin resistance and hyperlipidemia.	Quercetin	0-9	insulin	Homo sapiens	90-97
24491314-8	2014	Quercetin effectively restored high fructose-induced hypothalamic insulin signaling defect by up-regulating the phosphorylation of insulin receptor and protein kinase B.	Quercetin	0-9	insulin	Homo sapiens	66-73
24491314-9	2014	Furthermore, quercetin was found to reduce metabolic nutrient sensors adenosine monophosphate-activated protein kinase (AMPK) activation and thioredoxin-interacting protein (TXNIP) overexpression, as well as the glutamine-glutamate cycle dysfunction in the hypothalamus of high fructose-fed rats.	Quercetin	13-22	thioredoxin interacting protein	Rattus norvegicus	141-172
24491314-9	2014	Furthermore, quercetin was found to reduce metabolic nutrient sensors adenosine monophosphate-activated protein kinase (AMPK) activation and thioredoxin-interacting protein (TXNIP) overexpression, as well as the glutamine-glutamate cycle dysfunction in the hypothalamus of high fructose-fed rats.	Quercetin	13-22	thioredoxin interacting protein	Rattus norvegicus	174-179
24444877-6	2014	We observed that only four polyphenols belonging to flavonoids group: procyanidin B2, cyanidin, quercetin and silybin, had inhibitory effect on FXa activity.	Quercetin	96-105	coagulation factor X	Homo sapiens	144-147
24444877-7	2014	Bioinformatic analyses revealed that procyanidin B2, cyanidin, quercetin and silybin bound in the S1-S4 pockets located in vicinity of the FXa active site and blocked access of substrates to Ser195.	Quercetin	63-72	coagulation factor X	Homo sapiens	139-142
24491483-0	2014	Pharmacophore model of the quercetin binding site of the SIRT6 protein.	Quercetin	27-36	sirtuin 6	Homo sapiens	57-62
24491483-2	2014	We have previously reported on the identification of quercetin and vitexin as SIRT6 inhibitors, and studied structurally related flavonoids including luteolin, kaempferol, apigenin and naringenin.	Quercetin	53-62	sirtuin 6	Homo sapiens	78-83
24491483-4	2014	The previous study generated a preliminary pharmacophore for the quercetin binding site on SIRT6, containing 3 hydrogen bond donors and one hydrogen bond acceptor.	Quercetin	65-74	sirtuin 6	Homo sapiens	91-96
24491314-12	2014	These results provide in vivo evidence that quercetin-mediated down-regulation of AMPK/TXNIP and subsequent inhibition of NF-kappaB pathway/NLRP3 inflammasome activation in the hypothalamus of rats may be associated with the reduction of hypothalamic inflammatory lesions, contributing to the improvement of hypothalamic insulin signaling defect in this model.	Quercetin	44-53	NLR family, pyrin domain containing 3	Rattus norvegicus	140-145
24491314-13	2014	Thus, quercetin with the central activity may be a therapeutic for high fructose-induced insulin resistance and hyperlipidemia in humans.	Quercetin	6-15	insulin	Homo sapiens	89-96
24297068-4	2014	The anti-inflammatory efficacy of quercetin nanovesicles was assessed in vivo on TPA-treated mice dorsal skin by the determination of two biomarkers: oedema formation and myeloperoxidase activity.	Quercetin	34-43	myeloperoxidase	Mus musculus	171-186
24362044-7	2014	The efflux mechanism related with P-glycoprotein also existed with the polar flavonoids; verapamil could enhance the permeation of rutin and quercetin via inhibition of P-glycoprotein.	Quercetin	141-150	ATP binding cassette subfamily B member 1	Homo sapiens	34-48
24761121-8	2014	However, the experimental NASH rats treated with pioglitazone, with quercetin and with hydroxy citric acid showed an obvious decrease in ALT, AST, GGT and LDH levels when compared with that of NASH induced group.	Quercetin	68-77	gamma-glutamyltransferase 1	Rattus norvegicus	147-150
24362044-7	2014	The efflux mechanism related with P-glycoprotein also existed with the polar flavonoids; verapamil could enhance the permeation of rutin and quercetin via inhibition of P-glycoprotein.	Quercetin	141-150	ATP binding cassette subfamily B member 1	Homo sapiens	169-183
24378351-0	2014	Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1.	Quercetin	60-69	toll-like receptor 4	Mus musculus	127-130
24447267-3	2014	In this study, we evaluated the protective capacity of melatonin and quercetin against CCl4-induced oxidative lung damage in rats.	Quercetin	69-78	C-C motif chemokine ligand 4	Rattus norvegicus	87-91
24462958-7	2014	Water solubility was increased 22.75-, 15.15-, and 12.86-fold for isorhamnetin, kaempferol, and quercetin, respectively, in the presence of 20mg/mL IP6.	Quercetin	96-105	DnaJ heat shock protein family (Hsp40) member C14	Mus musculus	145-151
24586721-0	2014	Dietary quercetin supplementation in mice increases skeletal muscle PGC1alpha expression, improves mitochondrial function and attenuates insulin resistance in a time-specific manner.	Quercetin	8-17	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	68-77
24586721-3	2014	The aim of this study was to investigate whether differing doses of quercetin act in a time-dependent manner to attenuate HFD-induced IR in association with improved skeletal muscle mitochondrial function and PGC1alpha expression.	Quercetin	68-77	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	209-218
24586721-7	2014	RESULTS: Quercetin at 50 ug/day for 8 wk attenuated HFD-induced increases in fat mass, body weight and IR and increased PGC1alpha expression, whereas 600 ug/day of quercetin exacerbated fat mass accumulation without altering body weight, IR or PGC1alpha.	Quercetin	9-18	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	120-129
24586721-7	2014	RESULTS: Quercetin at 50 ug/day for 8 wk attenuated HFD-induced increases in fat mass, body weight and IR and increased PGC1alpha expression, whereas 600 ug/day of quercetin exacerbated fat mass accumulation without altering body weight, IR or PGC1alpha.	Quercetin	9-18	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	244-253
24586721-7	2014	RESULTS: Quercetin at 50 ug/day for 8 wk attenuated HFD-induced increases in fat mass, body weight and IR and increased PGC1alpha expression, whereas 600 ug/day of quercetin exacerbated fat mass accumulation without altering body weight, IR or PGC1alpha.	Quercetin	164-173	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	244-253
24586721-10	2014	CONCLUSIONS/INTERPRETATION: Chronic dietary quercetin supplementation at low but not higher dose ameliorates the development of diet-induced IR while increasing PGC1alpha expression in muscle, suggesting that skeletal muscle may be an important target for the insulin-sensitizing effects of a low dose of quercetin.	Quercetin	44-53	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	161-170
24625230-6	2014	The down-regulation of HSP70 using quercetin, a HSPs synthesis inhibitor, or small interfering RNAs (siRNA) reduced the viral protein level and viral production.	Quercetin	35-44	heat shock protein family A (Hsp70) member 4	Homo sapiens	23-28
24593786-8	2014	The protective effect of quercetin on mitochondrial function was accompanied by a reduction in CCK-induced changes to the cell membrane.	Quercetin	25-34	cholecystokinin	Rattus norvegicus	95-98
24593786-10	2014	In addition, quercetin strongly inhibited CCK-induced trypsin activity.	Quercetin	13-22	cholecystokinin	Rattus norvegicus	42-45
24176370-2	2014	Hence new complex, quercetin with cadmium was synthesised, and the synthesised complex structures were determined by UV-vis spectrophotometry, infrared spectroscopy, thermogravimetry and differential thermal analysis techniques (UV-vis, IR, TGA and DTA).	Quercetin	19-28	T-box transcription factor 1	Homo sapiens	241-244
24465016-0	2014	Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKalpha1/SIRT1.	Quercetin	0-9	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	102-112
24465016-0	2014	Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKalpha1/SIRT1.	Quercetin	0-9	sirtuin 1	Mus musculus	113-118
24465016-8	2014	Dietary quercetin also modified the phenotype ratio of M1/M2 macrophages, lowered the levels of proinflammatory cytokines, and enhanced adenosine monophosphate-activated protein kinase (AMPK) alpha1 phosphorylation and silent information regulator 1 (SIRT1) expression in EATs.	Quercetin	8-17	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	186-190
24465016-8	2014	Dietary quercetin also modified the phenotype ratio of M1/M2 macrophages, lowered the levels of proinflammatory cytokines, and enhanced adenosine monophosphate-activated protein kinase (AMPK) alpha1 phosphorylation and silent information regulator 1 (SIRT1) expression in EATs.	Quercetin	8-17	sirtuin 1	Mus musculus	219-249
24465016-8	2014	Dietary quercetin also modified the phenotype ratio of M1/M2 macrophages, lowered the levels of proinflammatory cytokines, and enhanced adenosine monophosphate-activated protein kinase (AMPK) alpha1 phosphorylation and silent information regulator 1 (SIRT1) expression in EATs.	Quercetin	8-17	sirtuin 1	Mus musculus	251-256
24465016-9	2014	Further, using AMPK activator 5-aminoimidazole-4-carboxamide-1-beta4-ribofuranoside and inhibitor Compound C, we found that quercetin inhibited polarization and inflammation of mouse bone marrow-derived macrophages through an AMPKalpha1/SIRT1-mediated mechanism.	Quercetin	124-133	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	15-19
24465016-9	2014	Further, using AMPK activator 5-aminoimidazole-4-carboxamide-1-beta4-ribofuranoside and inhibitor Compound C, we found that quercetin inhibited polarization and inflammation of mouse bone marrow-derived macrophages through an AMPKalpha1/SIRT1-mediated mechanism.	Quercetin	124-133	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	226-236
24465016-9	2014	Further, using AMPK activator 5-aminoimidazole-4-carboxamide-1-beta4-ribofuranoside and inhibitor Compound C, we found that quercetin inhibited polarization and inflammation of mouse bone marrow-derived macrophages through an AMPKalpha1/SIRT1-mediated mechanism.	Quercetin	124-133	sirtuin 1	Mus musculus	237-242
24465016-10	2014	In conclusion, dietary quercetin might suppress ATM infiltration and inflammation through the AMPKalpha1/SIRT1 pathway in HFD-fed mice.	Quercetin	23-32	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	94-104
24465016-10	2014	In conclusion, dietary quercetin might suppress ATM infiltration and inflammation through the AMPKalpha1/SIRT1 pathway in HFD-fed mice.	Quercetin	23-32	sirtuin 1	Mus musculus	105-110
24492281-0	2014	Modulation of PI3K-LXRalpha-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin.	Quercetin	139-148	nuclear receptor subfamily 1 group H member 3	Homo sapiens	19-27
24492281-6	2014	Quercetin also inhibited liver X receptor (LXR)alpha-induced lipid accumulation in LXRalpha-overexpressing and replicon-containing Huh7 cells.	Quercetin	0-9	nuclear receptor subfamily 1 group H member 3	Homo sapiens	43-52
24492281-6	2014	Quercetin also inhibited liver X receptor (LXR)alpha-induced lipid accumulation in LXRalpha-overexpressing and replicon-containing Huh7 cells.	Quercetin	0-9	nuclear receptor subfamily 1 group H member 3	Homo sapiens	83-91
24492281-7	2014	The mechanism underlying the LXRalpha-dependent lipogenesis modulatory effect of quercetin in HCV-replicating cells seems to involve phosphatidylinositol 3-kinase (PI3K)/AKT pathway inactivation.	Quercetin	81-90	nuclear receptor subfamily 1 group H member 3	Homo sapiens	29-37
24492281-9	2014	Inactivation of the PI3K pathway by quercetin may contribute to the repression of LXRalpha-dependent lipogenesis and to the inhibition of viral replication induced by the flavonol.	Quercetin	36-45	nuclear receptor subfamily 1 group H member 3	Homo sapiens	82-90
24492281-10	2014	Combined, our data suggest that oxidative/nitrosative stress blockage and subsequent modulation of PI3K-LXRalpha-mediated lipogenesis might contribute to the inhibitory effect of quercetin on HCV replication.	Quercetin	179-188	nuclear receptor subfamily 1 group H member 3	Homo sapiens	104-112
24559113-2	2014	Dietary components such as sulforaphane in broccoli and quercetin in onions have been shown to be inducers of Nrf2.	Quercetin	56-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	110-114
24693251-5	2014	The presence of catechin or quercetin at 10 muM have no effect on SB-induced toxicity at high concentrations of SB (50 and 100 mug/mL).	Quercetin	28-37	latexin	Homo sapiens	44-47
24238016-8	2014	However, both galangin and 3,6-DHF increased the affinity of Ca2+ for the ATPase by decreasing the Ca2+-dissociation rate constant, whereas quercetin had little effect.	Quercetin	140-149	dynein axonemal heavy chain 8	Homo sapiens	74-80
24531473-7	2014	Lower fluorescent signals were reported after soaking SKF86002-Pim1 and SKF86002-HCK co-crystals with the inhibitors quercetin, a quinazoline derivative and A-419259.	Quercetin	117-126	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	63-67
24531473-7	2014	Lower fluorescent signals were reported after soaking SKF86002-Pim1 and SKF86002-HCK co-crystals with the inhibitors quercetin, a quinazoline derivative and A-419259.	Quercetin	117-126	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
24275163-0	2014	Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling.	Quercetin	0-9	signal transducer and activator of transcription 3	Mus musculus	55-60
24275163-5	2014	In this study, we sought to test the involvement of STAT3 signaling in the inhibitory effects of quercetin on melanoma cell growth, migration and invasion.	Quercetin	97-106	signal transducer and activator of transcription 3	Mus musculus	52-57
24275163-7	2014	Mechanistic study indicated that quercetin inhibited the activation of STAT3 signaling by interfering with STAT3 phosphorylation, and reducing STAT3 nuclear localization.	Quercetin	33-42	signal transducer and activator of transcription 3	Mus musculus	71-76
24275163-7	2014	Mechanistic study indicated that quercetin inhibited the activation of STAT3 signaling by interfering with STAT3 phosphorylation, and reducing STAT3 nuclear localization.	Quercetin	33-42	signal transducer and activator of transcription 3	Mus musculus	107-112
24275163-7	2014	Mechanistic study indicated that quercetin inhibited the activation of STAT3 signaling by interfering with STAT3 phosphorylation, and reducing STAT3 nuclear localization.	Quercetin	33-42	signal transducer and activator of transcription 3	Mus musculus	107-112
24275163-9	2014	Importantly, overexpression of constitutively active STAT3 partially rescued the growth inhibiting effects induced by quercetin.	Quercetin	118-127	signal transducer and activator of transcription 3	Mus musculus	53-58
24275163-10	2014	Furthermore, quercetin suppressed A375 tumor growth and STAT3 activities in xenografted mice model, and inhibited murine B16F10 cells lung metastasis in an animal model.	Quercetin	13-22	signal transducer and activator of transcription 3	Mus musculus	56-61
24275163-11	2014	Overall, these results indicate that the antitumor activity of quercetin is at least partially due to inhibition of STAT3 signaling in melanoma cells.	Quercetin	63-72	signal transducer and activator of transcription 3	Mus musculus	116-121
24275163-12	2014	Our findings provided new insight into the action of quercetin potently inhibits the STAT3 signaling pathway, suggesting it has a potential role in the prevention and treatment of melanoma.	Quercetin	53-62	signal transducer and activator of transcription 3	Mus musculus	85-90
24271942-9	2014	Quercetin, an inhibitor of Hsc70 and Hsp70, significantly reduced SBL/RC-RNase-induced apoptosis.	Quercetin	0-9	heat shock protein 8	Mus musculus	27-32
24271942-9	2014	Quercetin, an inhibitor of Hsc70 and Hsp70, significantly reduced SBL/RC-RNase-induced apoptosis.	Quercetin	0-9	heat shock protein 1B	Mus musculus	37-42
24337353-6	2014	In addition, quercetin-treated mice exhibited significantly lower expression of the p47phox subunit of nicotinamide adenine dinucleotide phosphate oxidase and inducible nitric oxide synthase, as well as coordinated downregulation of manganese-superoxide dismutase activities and glutathione peroxidase (GPx)-1 and GPx-3 expression.	Quercetin	13-22	glutathione peroxidase 1	Mus musculus	279-309
24622831-10	2014	On contrary to these two drugs, the experimental NASH rats treated with quercetin showed significant increase in the levels of antioxidants as follows: GSH, catalase, SOD, GPx, GR and GST when compared with that of NASH induced group.	Quercetin	72-81	catalase	Rattus norvegicus	157-165
24622831-10	2014	On contrary to these two drugs, the experimental NASH rats treated with quercetin showed significant increase in the levels of antioxidants as follows: GSH, catalase, SOD, GPx, GR and GST when compared with that of NASH induced group.	Quercetin	72-81	glutathione-disulfide reductase	Rattus norvegicus	177-179
24622831-10	2014	On contrary to these two drugs, the experimental NASH rats treated with quercetin showed significant increase in the levels of antioxidants as follows: GSH, catalase, SOD, GPx, GR and GST when compared with that of NASH induced group.	Quercetin	72-81	hematopoietic prostaglandin D synthase	Rattus norvegicus	184-187
24337353-6	2014	In addition, quercetin-treated mice exhibited significantly lower expression of the p47phox subunit of nicotinamide adenine dinucleotide phosphate oxidase and inducible nitric oxide synthase, as well as coordinated downregulation of manganese-superoxide dismutase activities and glutathione peroxidase (GPx)-1 and GPx-3 expression.	Quercetin	13-22	neutrophil cytosolic factor 1	Mus musculus	84-91
24337353-6	2014	In addition, quercetin-treated mice exhibited significantly lower expression of the p47phox subunit of nicotinamide adenine dinucleotide phosphate oxidase and inducible nitric oxide synthase, as well as coordinated downregulation of manganese-superoxide dismutase activities and glutathione peroxidase (GPx)-1 and GPx-3 expression.	Quercetin	13-22	nitric oxide synthase 2, inducible	Mus musculus	159-190
24337353-6	2014	In addition, quercetin-treated mice exhibited significantly lower expression of the p47phox subunit of nicotinamide adenine dinucleotide phosphate oxidase and inducible nitric oxide synthase, as well as coordinated downregulation of manganese-superoxide dismutase activities and glutathione peroxidase (GPx)-1 and GPx-3 expression.	Quercetin	13-22	glutathione peroxidase 3	Mus musculus	314-319
24337353-8	2014	Gelatin zymography showed that quercetin eliminated matrix metalloproteinase (MMP)-2 and MMP-9 activation during AAA formation.	Quercetin	31-40	matrix metallopeptidase 2	Mus musculus	52-84
24337353-8	2014	Gelatin zymography showed that quercetin eliminated matrix metalloproteinase (MMP)-2 and MMP-9 activation during AAA formation.	Quercetin	31-40	matrix metallopeptidase 9	Mus musculus	89-94
24337353-9	2014	In conclusion, the inhibitory effects of quercetin on oxidative stress and MMP activation, through modulation of JNK/AP-1 signaling, may partly account for its benefit in CaCl2-induced AAA.	Quercetin	41-50	matrix metallopeptidase 2	Mus musculus	75-78
24516353-7	2014	Treatment with a high dose (50 mg/kg) of quercetin markedly enhanced the activities of copper/zinc superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GSH-Px), and treatment with this dose significantly reduced the level of malondialdehyde (MDA).	Quercetin	41-50	superoxide dismutase 1	Rattus norvegicus	121-129
24516353-8	2014	Caspase-3 and brain edema was ameliorated and neurobehavioral deficits improved in rats that received the high dose of quercetin.	Quercetin	119-128	caspase 3	Rattus norvegicus	0-9
24354565-0	2014	Computational studies of the regioselectivities of COMT-catalyzed meta-/para-O methylations of luteolin and quercetin.	Quercetin	108-117	catechol-O-methyltransferase	Homo sapiens	51-55
24354565-4	2014	To elucidate the mechanism for different preferences of methylations of quercetin and luteolin, we performed a theoretical investigation on the different regioseletivities of COMT-catalyzed methylations for quercetin and luteolin by a combined approach of MD simulations, ab initio calculations, and QM/MM computations.	Quercetin	72-81	catechol-O-methyltransferase	Homo sapiens	175-179
24354565-4	2014	To elucidate the mechanism for different preferences of methylations of quercetin and luteolin, we performed a theoretical investigation on the different regioseletivities of COMT-catalyzed methylations for quercetin and luteolin by a combined approach of MD simulations, ab initio calculations, and QM/MM computations.	Quercetin	207-216	catechol-O-methyltransferase	Homo sapiens	175-179
24296267-3	2014	Meanwhile, the HSF1 transcription inhibitor quercetin increased UVA-induced apoptosis, activation of JNK, expression of XO and iNOS and release of NO/ROS.	Quercetin	44-53	heat shock transcription factor 1	Homo sapiens	15-19
24211784-9	2014	In addition, quercetin (Que), a beta-catenin pathway inhibitor, abolished such a recovery effect of VPA.	Quercetin	13-22	catenin beta 1	Rattus norvegicus	32-44
24211784-9	2014	In addition, quercetin (Que), a beta-catenin pathway inhibitor, abolished such a recovery effect of VPA.	Quercetin	24-27	catenin beta 1	Rattus norvegicus	32-44
24239714-6	2014	In HUVECs, quercetin inhibited cell viability, the expression of vascular endothelial growth factor receptor 2 and tube formation in a dose-dependent manner.	Quercetin	11-20	kinase insert domain receptor (a type III receptor tyrosine kinase)	Danio rerio	65-110
24296267-3	2014	Meanwhile, the HSF1 transcription inhibitor quercetin increased UVA-induced apoptosis, activation of JNK, expression of XO and iNOS and release of NO/ROS.	Quercetin	44-53	mitogen-activated protein kinase 8	Homo sapiens	101-104
24296267-3	2014	Meanwhile, the HSF1 transcription inhibitor quercetin increased UVA-induced apoptosis, activation of JNK, expression of XO and iNOS and release of NO/ROS.	Quercetin	44-53	nitric oxide synthase 2	Homo sapiens	127-131
25493440-0	2014	The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide.	Quercetin	16-25	myeloperoxidase	Homo sapiens	57-72
25493440-1	2014	The protective action of quercetin against the pro-oxidant and apoptotic effect of etoposide was investigated in HL-60 cells with a high level of myeloperoxidase (MPO) activity and in cells treated with MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH).	Quercetin	25-34	myeloperoxidase	Homo sapiens	146-161
25493440-1	2014	The protective action of quercetin against the pro-oxidant and apoptotic effect of etoposide was investigated in HL-60 cells with a high level of myeloperoxidase (MPO) activity and in cells treated with MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH).	Quercetin	25-34	myeloperoxidase	Homo sapiens	163-166
25493440-1	2014	The protective action of quercetin against the pro-oxidant and apoptotic effect of etoposide was investigated in HL-60 cells with a high level of myeloperoxidase (MPO) activity and in cells treated with MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH).	Quercetin	25-34	myeloperoxidase	Homo sapiens	203-206
25493440-2	2014	Quercetin significantly protected MPO-rich cells against the pro-oxidative (p&lt;0.05) and apoptotic (p&lt;0.05) effects of etoposide.	Quercetin	0-9	myeloperoxidase	Homo sapiens	34-37
25004880-12	2014	Results showed that quercetin and catechin significantly decreased the proteins expression of iNOS, COX-2 and phospho-JNK.	Quercetin	20-29	cox2	Nelumbo nucifera	100-105
25004880-13	2014	Besides, the mRNAs and levels of IL-6 and TNF-alpha also decreased by quercetin and catechin treatment in LPS-induced RAW264.7 cells.	Quercetin	70-79	interleukin 6	Mus musculus	33-37
25004880-13	2014	Besides, the mRNAs and levels of IL-6 and TNF-alpha also decreased by quercetin and catechin treatment in LPS-induced RAW264.7 cells.	Quercetin	70-79	tumor necrosis factor	Mus musculus	42-51
25374189-9	2014	Apoptotic effects of liposomal quercetin (LQ, with cytomembrane-philia) combined with CD133 antiserum were also detected by CD133 immunocytochemistry combined with TUNEL assay.	Quercetin	31-40	prominin 1	Homo sapiens	124-129
24122665-3	2014	To this end, HepG2 cells were exposed to quercetin (50 muM) or cisplatin (10 muM) alone or combination of both and cell proliferation and apoptosis were investigated.	Quercetin	41-50	latexin	Homo sapiens	55-58
24122665-6	2014	Treatment with quercetin rather than cisplatin resulted in a marked elevation of p16 expression in HepG2 cells.	Quercetin	15-24	cyclin dependent kinase inhibitor 2A	Homo sapiens	81-84
24122665-7	2014	Targeted reduction of p16 using RNA interference technology partially reversed quercetin-induced cell cycle G1 arrest and apoptosis in HepG2 cells.	Quercetin	79-88	cyclin dependent kinase inhibitor 2A	Homo sapiens	22-25
24122665-8	2014	In conclusion, quercetin has suppressive activity against HCC cells through p16-mediated cell cycle arrest and apoptosis and its combination with cisplatin yielded synergistic inhibitory effects in suppressing cell growth and inducing apoptosis.	Quercetin	15-24	cyclin dependent kinase inhibitor 2A	Homo sapiens	76-79
25374189-6	2014	In E-cancer cells exposed to nanoliposomal quercetin (nLQ with cytomembrane permeability), down-regulation of NF-kappaBp65, histone deacetylase 1 (HDAC1) and cyclin D1 and up-regulation of caspase-3 were shown by immunoblotting, and attenuated HDAC1 with nuclear translocation and promoted E-cadherin expression were demonstrated by immunocytochemistry.	Quercetin	43-52	RELA proto-oncogene, NF-kB subunit	Homo sapiens	110-122
24001508-11	2014	Pretreatment of HeLa cells with quercetin alleviated H2O2-induced cell injury by improving redox balance as indicated by the increase in glutathione content and SOD (superoxide dismutase) levels as well as by the decrease in ROS level.	Quercetin	32-41	superoxide dismutase 1	Homo sapiens	161-164
25374189-6	2014	In E-cancer cells exposed to nanoliposomal quercetin (nLQ with cytomembrane permeability), down-regulation of NF-kappaBp65, histone deacetylase 1 (HDAC1) and cyclin D1 and up-regulation of caspase-3 were shown by immunoblotting, and attenuated HDAC1 with nuclear translocation and promoted E-cadherin expression were demonstrated by immunocytochemistry.	Quercetin	43-52	histone deacetylase 1	Homo sapiens	124-145
25374189-6	2014	In E-cancer cells exposed to nanoliposomal quercetin (nLQ with cytomembrane permeability), down-regulation of NF-kappaBp65, histone deacetylase 1 (HDAC1) and cyclin D1 and up-regulation of caspase-3 were shown by immunoblotting, and attenuated HDAC1 with nuclear translocation and promoted E-cadherin expression were demonstrated by immunocytochemistry.	Quercetin	43-52	histone deacetylase 1	Homo sapiens	147-152
25374189-6	2014	In E-cancer cells exposed to nanoliposomal quercetin (nLQ with cytomembrane permeability), down-regulation of NF-kappaBp65, histone deacetylase 1 (HDAC1) and cyclin D1 and up-regulation of caspase-3 were shown by immunoblotting, and attenuated HDAC1 with nuclear translocation and promoted E-cadherin expression were demonstrated by immunocytochemistry.	Quercetin	43-52	cyclin D1	Homo sapiens	158-167
25374189-6	2014	In E-cancer cells exposed to nanoliposomal quercetin (nLQ with cytomembrane permeability), down-regulation of NF-kappaBp65, histone deacetylase 1 (HDAC1) and cyclin D1 and up-regulation of caspase-3 were shown by immunoblotting, and attenuated HDAC1 with nuclear translocation and promoted E-cadherin expression were demonstrated by immunocytochemistry.	Quercetin	43-52	caspase 3	Homo sapiens	189-198
25374189-6	2014	In E-cancer cells exposed to nanoliposomal quercetin (nLQ with cytomembrane permeability), down-regulation of NF-kappaBp65, histone deacetylase 1 (HDAC1) and cyclin D1 and up-regulation of caspase-3 were shown by immunoblotting, and attenuated HDAC1 with nuclear translocation and promoted E-cadherin expression were demonstrated by immunocytochemistry.	Quercetin	43-52	histone deacetylase 1	Homo sapiens	244-249
25374189-6	2014	In E-cancer cells exposed to nanoliposomal quercetin (nLQ with cytomembrane permeability), down-regulation of NF-kappaBp65, histone deacetylase 1 (HDAC1) and cyclin D1 and up-regulation of caspase-3 were shown by immunoblotting, and attenuated HDAC1 with nuclear translocation and promoted E-cadherin expression were demonstrated by immunocytochemistry.	Quercetin	43-52	cadherin 1	Homo sapiens	290-300
24001508-11	2014	Pretreatment of HeLa cells with quercetin alleviated H2O2-induced cell injury by improving redox balance as indicated by the increase in glutathione content and SOD (superoxide dismutase) levels as well as by the decrease in ROS level.	Quercetin	32-41	superoxide dismutase 1	Homo sapiens	166-186
25025048-0	2014	Quercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A2*1C  (-2964G&gt;A) and *1F (734C&gt;A) gene polymorphisms.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-95
24987689-6	2014	DSE and quercetin have shown significant prophylactic effects by restoring the liver function markers (AST, ALT, ALP, serum bilirubin, and total protein) and antioxidant enzymes (SOD, CAT, GPx, and GST).	Quercetin	8-17	catalase	Rattus norvegicus	184-187
24987689-8	2014	The results indicated that the DSE and quercetin were significant for prophylactic activity against CCl4-induced liver damage in rats.	Quercetin	39-48	C-C motif chemokine ligand 4	Rattus norvegicus	100-104
24161694-0	2014	Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-kappaB and COX-2.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
24161694-0	2014	Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-kappaB and COX-2.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	143-152
24161694-0	2014	Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-kappaB and COX-2.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162
24161694-11	2014	Pre-treatment with quercetin ameliorated ROS and calcium release as well as NF-kappaB induction and expression.	Quercetin	19-28	nuclear factor kappa B subunit 1	Homo sapiens	76-85
24161694-12	2014	Quercetin induced Nrf-2 nuclear translocation and expression.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	18-23
24161694-13	2014	Quercetin"s anti-inflammatory property was exhibited as it down regulated COX-2.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
25025048-0	2014	Quercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A2*1C  (-2964G&gt;A) and *1F (734C&gt;A) gene polymorphisms.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	109-115
25025048-2	2014	Previous studies indicated that quercetin inhibited the activity of CYP1A2, and the combination of quercetin with the substrates of CYP1A2 might produce herb-drug interactions.	Quercetin	32-41	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	68-74
25025048-2	2014	Previous studies indicated that quercetin inhibited the activity of CYP1A2, and the combination of quercetin with the substrates of CYP1A2 might produce herb-drug interactions.	Quercetin	99-108	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	68-74
25025048-2	2014	Previous studies indicated that quercetin inhibited the activity of CYP1A2, and the combination of quercetin with the substrates of CYP1A2 might produce herb-drug interactions.	Quercetin	99-108	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	132-138
25025048-3	2014	This research aims to determine the effects of quercetin and the CYP1A2 gene polymorphisms, namely, CYP1A2*1C  (-2964G&gt;A) and *1F (734C&gt;A), on the metabolism of caffeine.	Quercetin	47-56	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	100-106
24533936-5	2014	A similar protective effect was also achieved with a dietary bioflavonoid quercetin that inhibits TG2 and beta-catenin signaling.	Quercetin	74-83	transglutaminase 2	Homo sapiens	98-101
24711995-6	2014	It showed that the viability of the cultured endometrial cells, the expression of CYP1A1 and CYP2B1, and the contents of TNF-alpha, E2, and IL-6 in the injured endometrial cells increased with the treatment of quercetin.	Quercetin	210-219	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	82-88
24711995-6	2014	It showed that the viability of the cultured endometrial cells, the expression of CYP1A1 and CYP2B1, and the contents of TNF-alpha, E2, and IL-6 in the injured endometrial cells increased with the treatment of quercetin.	Quercetin	210-219	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	93-99
24606795-21	2014	Several pharmacological strategies to trigger these signaling cascades, according to these authors, are the use of bezafibrate to activate the PPAR-PGC-1alpha axis, the activation of AMPK by resveratrol and the use of Sirt1 agonists such as quercetin or resveratrol.	Quercetin	241-250	sirtuin 1	Homo sapiens	218-223
24479689-6	2014	Moreover, an integrated in silico approach for the prediction of Phase I metabolism of the flavonoids quercetin, rutin, naringenin and naringin, which provided useful information about the most likely metabolites of these flavonoids and their interactions with amino acid residues of CYP2C9, is described.	Quercetin	102-111	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	284-290
24533936-5	2014	A similar protective effect was also achieved with a dietary bioflavonoid quercetin that inhibits TG2 and beta-catenin signaling.	Quercetin	74-83	catenin beta 1	Homo sapiens	106-118
24533936-6	2014	We have shown that quercetin intercepts the chondrogenic transformation of vascular smooth muscle and also drastically attenuates calcifying cartilaginous metaplasia in another model of AC caused by genetic loss of matrix gla protein (MGP).	Quercetin	19-28	matrix Gla protein	Homo sapiens	215-233
24533936-6	2014	We have shown that quercetin intercepts the chondrogenic transformation of vascular smooth muscle and also drastically attenuates calcifying cartilaginous metaplasia in another model of AC caused by genetic loss of matrix gla protein (MGP).	Quercetin	19-28	matrix Gla protein	Homo sapiens	235-238
24001813-6	2014	Collectively, these results suggest that PI3K is a molecular target of quercetin for the inhibition of H-Ras-induced invasion and migration of MCF10A cells.	Quercetin	71-80	HRas proto-oncogene, GTPase	Homo sapiens	103-108
25317811-4	2014	In this study, the comparative effect of pioglitazone, quercetin and hydroxy citric acid on liver CYP2E1 enzyme levels in experimentally induced NASH has been studied.	Quercetin	55-64	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	98-104
25317811-9	2014	It revealed low CYP2E1 in the experimentally induced NASH, treated with pioglitazone, quercetin and hydroxy citric acid.	Quercetin	86-95	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	16-22
25317811-12	2014	On contrary to the action of pioglitazone and hydroxy citric acid, quercetin showed an approximate 2-fold decrease in the level of CYP2E1 in experimental NASH treated with quercetin compared to NASH group.	Quercetin	67-76	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	131-137
25317811-12	2014	On contrary to the action of pioglitazone and hydroxy citric acid, quercetin showed an approximate 2-fold decrease in the level of CYP2E1 in experimental NASH treated with quercetin compared to NASH group.	Quercetin	172-181	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	131-137
25317811-13	2014	CONCLUSIONS: Being a powerful antioxidant, quercetin offers absolute protection to liver against NASH by reducing the levels of CYP2E1 and, thereby, reducing CYP2E1 mediated oxidative stress, which is believed to be the one of the key factor in the pathogenesis of NASH.	Quercetin	43-52	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	128-134
25317811-13	2014	CONCLUSIONS: Being a powerful antioxidant, quercetin offers absolute protection to liver against NASH by reducing the levels of CYP2E1 and, thereby, reducing CYP2E1 mediated oxidative stress, which is believed to be the one of the key factor in the pathogenesis of NASH.	Quercetin	43-52	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	158-164
25530789-6	2014	Quercetin can decrease the expression of ERalpha, ERbeta, and PR in hypothalamus, pituitary, and endometrium, thereby inhibiting estrogen and progesterone binding to their receptors to play the role of antiestrogen and progesterone.	Quercetin	0-9	estrogen receptor 1	Rattus norvegicus	41-48
25530789-6	2014	Quercetin can decrease the expression of ERalpha, ERbeta, and PR in hypothalamus, pituitary, and endometrium, thereby inhibiting estrogen and progesterone binding to their receptors to play the role of antiestrogen and progesterone.	Quercetin	0-9	estrogen receptor 2	Rattus norvegicus	50-56
25095668-6	2014	Application of Quercetin prevents the inhibition of TPP II activity in aorta tissues of rabbits and SHR at experimental hypercholesterolemia.	Quercetin	15-24	tripeptidyl peptidase 2	Rattus norvegicus	52-58
24001813-0	2014	Quercetin suppresses invasion and migration of H-Ras-transformed MCF10A human epithelial cells by inhibiting phosphatidylinositol 3-kinase.	Quercetin	0-9	HRas proto-oncogene, GTPase	Homo sapiens	47-52
24001813-0	2014	Quercetin suppresses invasion and migration of H-Ras-transformed MCF10A human epithelial cells by inhibiting phosphatidylinositol 3-kinase.	Quercetin	0-9	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	109-138
24001813-2	2014	In this study, we examined potential anti-metastatic effects and found that compared to resveratrol, quercetin more potently inhibits H-Ras-induced invasion and migration in MCF10A human epithelial cells, an effect likely mediated by the mitigation of matrix metalloproteinase (MMP)-2 activation.	Quercetin	101-110	HRas proto-oncogene, GTPase	Homo sapiens	134-139
25614714-7	2014	In vitro, quercetin markedly diminished transcript levels of inflammatory receptors and activation of their signaling molecules (ERK, p38 MAPK, and NF-kappaB) in cocultured myotubes/macrophages, and this was accompanied by reduced expression of the atrophic factors.	Quercetin	10-19	mitogen-activated protein kinase 14	Mus musculus	134-137
24001813-2	2014	In this study, we examined potential anti-metastatic effects and found that compared to resveratrol, quercetin more potently inhibits H-Ras-induced invasion and migration in MCF10A human epithelial cells, an effect likely mediated by the mitigation of matrix metalloproteinase (MMP)-2 activation.	Quercetin	101-110	matrix metallopeptidase 2	Homo sapiens	252-284
24001813-4	2014	Quercetin, but not resveratrol at equivalent concentrations, suppressed the phosphorylation of Akt and was a more potent inhibitor of PI3K activity than resveratrol.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	95-98
23884338-7	2014	Inhibition of HSP70 by quercetin suppressed Treg expansion, as well as renoprotective effects.	Quercetin	23-32	heat shock protein 1B	Mus musculus	14-19
24610996-5	2014	Only six compounds, cyanidin, quercetin, silybin, cyanin, (+)-catechin and (-)-epicatechin, of all examined in this study polyphenols caused the inhibition of thrombin amidolytic activity.	Quercetin	30-39	coagulation factor II, thrombin	Homo sapiens	159-167
24610996-6	2014	But only three of the six compounds (cyanidin, quercetin and silybin) changed thrombin proteolytic activity.	Quercetin	47-56	coagulation factor II, thrombin	Homo sapiens	78-86
24610996-7	2014	BIAcore analyses demonstrated that cyanidin and quercetin caused a strong response in the interaction with immobilized thrombin, while cyanin and (-)-epicatechin induced a low response.	Quercetin	48-57	coagulation factor II, thrombin	Homo sapiens	119-127
24173369-0	2014	Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a.	Quercetin	15-24	microRNA 27a	Homo sapiens	117-129
24141791-0	2014	Novel quercetin derivatives in treatment of peroxynitrite-oxidized SERCA1.	Quercetin	6-15	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	67-73
24141791-4	2014	Quercetin derivatives were found to be weaker antioxidants compared with Q, as indicated by their ability to scavenge peroxynitrite and prevent of SERCA1 carbonylation, both decreasing in the order (Q &gt; MPQ &gt; CHQ).	Quercetin	0-9	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	147-153
24141791-9	2014	More expressive alterations of conformation in the transmembrane region of SERCA1 induced by quercetin derivatives, as compared with Q, may at least partially correlate with their higher lipophilicities.	Quercetin	93-102	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	75-81
24269256-9	2014	Silibinin, quercetin and genistein inhibited ssDNA binding, DNA chain annealing and DNA unwinding activities of purified nuclear mono-ubiquitinated annexin A1.	Quercetin	11-20	annexin A1	Homo sapiens	148-158
24121953-6	2013	Apigenin and the methylated metabolite of quercetin, tamarixetin significantly reduced thrombus volume at concentrations (5 muM) that suggested their reported physiological levels (0.1-1 muM) may exert low levels of inhibition.	Quercetin	42-51	latexin	Homo sapiens	124-127
24246038-6	2013	These results demonstrated that quercetin exhibits protective effects in A. actinomycetemcomitans-induced periodontitis in mice by modulating cytokine and ICAM-1 production.	Quercetin	32-41	intercellular adhesion molecule 1	Mus musculus	155-161
24318284-4	2013	Additionally, the expression of tyrosinase protein was significantly enhanced in proportion to increases in the concentration of quercetin added.	Quercetin	129-138	tyrosinase	Mus musculus	32-42
24318284-6	2013	In addition, tyrosinase-related protein-2 (TRP-2), which is a melanogenic enzyme, was increased depending on the concentration of added quercetin but its mRNA expression was not altered.	Quercetin	136-145	dopachrome tautomerase	Mus musculus	13-41
24318284-6	2013	In addition, tyrosinase-related protein-2 (TRP-2), which is a melanogenic enzyme, was increased depending on the concentration of added quercetin but its mRNA expression was not altered.	Quercetin	136-145	dopachrome tautomerase	Mus musculus	43-48
24318284-7	2013	These results show that quercetin stimulates the synthesis of tyrosinase protein as well as TRP-2 protein, thereby enhancing melanin producibility in hair follicle tissues from the buccal region of C3H/HeN Jel mice.	Quercetin	24-33	tyrosinase	Mus musculus	62-72
24318284-7	2013	These results show that quercetin stimulates the synthesis of tyrosinase protein as well as TRP-2 protein, thereby enhancing melanin producibility in hair follicle tissues from the buccal region of C3H/HeN Jel mice.	Quercetin	24-33	dopachrome tautomerase	Mus musculus	92-97
24126416-0	2013	Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment.	Quercetin	113-122	heat shock protein family B (small) member 1	Homo sapiens	13-18
24126416-0	2013	Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment.	Quercetin	113-122	heat shock protein family A (Hsp70) member 1A	Homo sapiens	23-28
24126416-1	2013	The aim of the present study was to investigate whether silencing of Hsp27 or Hsp72 expression in glioblastoma multiforme T98G and anaplastic astrocytoma MOGGCCM cells increases their sensitivity to programmed cell death induction upon temozolomide and/or quercetin treatment.	Quercetin	256-265	heat shock protein family B (small) member 1	Homo sapiens	69-74
24126416-1	2013	The aim of the present study was to investigate whether silencing of Hsp27 or Hsp72 expression in glioblastoma multiforme T98G and anaplastic astrocytoma MOGGCCM cells increases their sensitivity to programmed cell death induction upon temozolomide and/or quercetin treatment.	Quercetin	256-265	heat shock protein family A (Hsp70) member 1A	Homo sapiens	78-83
24126416-10	2013	Our results indicate that blocking of Hsp27 and Hsp72 expression makes T98G cells and MOGGCCM cells extremely vulnerable to apoptosis induction upon temozolomide and quercetin treatment and that programmed cell death is initiated by an internal signal.	Quercetin	166-175	heat shock protein family B (small) member 1	Homo sapiens	38-43
24126416-10	2013	Our results indicate that blocking of Hsp27 and Hsp72 expression makes T98G cells and MOGGCCM cells extremely vulnerable to apoptosis induction upon temozolomide and quercetin treatment and that programmed cell death is initiated by an internal signal.	Quercetin	166-175	heat shock protein family A (Hsp70) member 1A	Homo sapiens	48-53
24102669-4	2013	Among the flavonoids (quercetin, genistein and baicalin), quercetin induced the highest alkaline phosphatase (ALP) activity of human dental pulp (HDP) cells.	Quercetin	22-31	alkaline phosphatase, placental	Homo sapiens	88-108
24102669-4	2013	Among the flavonoids (quercetin, genistein and baicalin), quercetin induced the highest alkaline phosphatase (ALP) activity of human dental pulp (HDP) cells.	Quercetin	22-31	alkaline phosphatase, placental	Homo sapiens	110-113
24102669-4	2013	Among the flavonoids (quercetin, genistein and baicalin), quercetin induced the highest alkaline phosphatase (ALP) activity of human dental pulp (HDP) cells.	Quercetin	58-67	alkaline phosphatase, placental	Homo sapiens	88-108
24102669-4	2013	Among the flavonoids (quercetin, genistein and baicalin), quercetin induced the highest alkaline phosphatase (ALP) activity of human dental pulp (HDP) cells.	Quercetin	58-67	alkaline phosphatase, placental	Homo sapiens	110-113
24211435-0	2013	RyR3 in situ regulation by Ca(2+) and quercetin and the RyR3-mediated Ca(2+) release flux in intact Jurkat cells.	Quercetin	38-47	ryanodine receptor 3	Homo sapiens	0-4
24211435-2	2013	By performing conformation selective measurements in which quercetin was used as a fluorescent marker for RyR3 (ryanodine receptor type 3) in Jurkat cells, we now find that the rectified RyR3 channel in open conformation may be regulated in situ by two cytosolic activating Ca(2+) sites, of low and high affinity, respectively, whereas no inhibitory Ca(2+) effect could be delineated.	Quercetin	59-68	ryanodine receptor 3	Homo sapiens	106-110
24211435-2	2013	By performing conformation selective measurements in which quercetin was used as a fluorescent marker for RyR3 (ryanodine receptor type 3) in Jurkat cells, we now find that the rectified RyR3 channel in open conformation may be regulated in situ by two cytosolic activating Ca(2+) sites, of low and high affinity, respectively, whereas no inhibitory Ca(2+) effect could be delineated.	Quercetin	59-68	ryanodine receptor 3	Homo sapiens	112-137
24211435-2	2013	By performing conformation selective measurements in which quercetin was used as a fluorescent marker for RyR3 (ryanodine receptor type 3) in Jurkat cells, we now find that the rectified RyR3 channel in open conformation may be regulated in situ by two cytosolic activating Ca(2+) sites, of low and high affinity, respectively, whereas no inhibitory Ca(2+) effect could be delineated.	Quercetin	59-68	ryanodine receptor 3	Homo sapiens	187-191
24211435-4	2013	RyR3 also seems to possess one activating and two inhibitory quercetin sites.	Quercetin	61-70	ryanodine receptor 3	Homo sapiens	0-4
24102669-6	2013	However, increased expression of dentin sialophosphoprotein (DSPP) mRNA and mineral deposition were seen in cultures treated with quercetin compared with phenamil.	Quercetin	130-139	dentin sialophosphoprotein	Homo sapiens	33-59
24102669-6	2013	However, increased expression of dentin sialophosphoprotein (DSPP) mRNA and mineral deposition were seen in cultures treated with quercetin compared with phenamil.	Quercetin	130-139	dentin sialophosphoprotein	Homo sapiens	61-65
24102669-8	2013	The increase in ALP activity in the quercetin-treated cells was not affected by ICI 182,780, an estrogen receptor inhibitor, and was partially blocked by PD98059, an extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor.	Quercetin	36-45	alkaline phosphatase, placental	Homo sapiens	16-19
24102669-8	2013	The increase in ALP activity in the quercetin-treated cells was not affected by ICI 182,780, an estrogen receptor inhibitor, and was partially blocked by PD98059, an extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor.	Quercetin	36-45	mitogen-activated protein kinase 1	Homo sapiens	166-207
24102669-8	2013	The increase in ALP activity in the quercetin-treated cells was not affected by ICI 182,780, an estrogen receptor inhibitor, and was partially blocked by PD98059, an extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor.	Quercetin	36-45	mitogen-activated protein kinase 3	Homo sapiens	209-215
24102669-9	2013	This suggests that ERK1/2 is activated in the quercetin-induced differentiation of HDP cells without the mediation of estrogen receptors, which are known to be involved in osteoblast differentiation induced by quercetin.	Quercetin	46-55	mitogen-activated protein kinase 3	Homo sapiens	19-25
24121953-6	2013	Apigenin and the methylated metabolite of quercetin, tamarixetin significantly reduced thrombus volume at concentrations (5 muM) that suggested their reported physiological levels (0.1-1 muM) may exert low levels of inhibition.	Quercetin	42-51	latexin	Homo sapiens	187-190
24017971-0	2013	Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1.	Quercetin	8-17	apolipoprotein E	Mus musculus	92-108
23735482-0	2013	Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-kappaB-induced inflammatory mediators production in RAW 264.7 cells.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-164
23735482-8	2013	Quercetin attenuated p38(MAPK) and JNK1/2 but not ERK1/2 activations and this effect was further confirmed by SB203580 and SP600125-mediated suppressions of HO-1, iNOS, and COX-2 protein expressions.	Quercetin	0-9	mitogen-activated protein kinase 14	Mus musculus	21-24
23735482-8	2013	Quercetin attenuated p38(MAPK) and JNK1/2 but not ERK1/2 activations and this effect was further confirmed by SB203580 and SP600125-mediated suppressions of HO-1, iNOS, and COX-2 protein expressions.	Quercetin	0-9	mitogen-activated protein kinase 8	Mus musculus	35-41
23735482-12	2013	Quercetin limits LPS-induced inflammation via inhibition of Src- and Syk-mediated PI3K-(p85) tyrosine phosphorylation and subsequent TLR4/MyD88/PI3K complex formation that limits activation of downstream signaling pathways.	Quercetin	0-9	myeloid differentiation primary response gene 88	Mus musculus	138-143
23735482-6	2013	Quercetin inhibited LPS-induced NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and GM-CSF mRNA and protein expressions while it promoted HO-1 induction in a dose- and time-dependent manner.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	42-46
23735482-8	2013	Quercetin attenuated p38(MAPK) and JNK1/2 but not ERK1/2 activations and this effect was further confirmed by SB203580 and SP600125-mediated suppressions of HO-1, iNOS, and COX-2 protein expressions.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	163-167
23735482-8	2013	Quercetin attenuated p38(MAPK) and JNK1/2 but not ERK1/2 activations and this effect was further confirmed by SB203580 and SP600125-mediated suppressions of HO-1, iNOS, and COX-2 protein expressions.	Quercetin	0-9	cytochrome c oxidase II, mitochondrial	Mus musculus	173-178
23735482-6	2013	Quercetin inhibited LPS-induced NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and GM-CSF mRNA and protein expressions while it promoted HO-1 induction in a dose- and time-dependent manner.	Quercetin	0-9	cytochrome c oxidase II, mitochondrial	Mus musculus	48-53
23735482-9	2013	Moreover, quercetin arrested Src, PI3K, PDK1 and Akt activation in a time- and dose-dependent manner, which was comparable to PP2 and LY294002 inhibition of Src, PI3K/Akt and iNOS expressions.	Quercetin	10-19	Rous sarcoma oncogene	Mus musculus	29-32
23735482-6	2013	Quercetin inhibited LPS-induced NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and GM-CSF mRNA and protein expressions while it promoted HO-1 induction in a dose- and time-dependent manner.	Quercetin	0-9	tumor necrosis factor	Mus musculus	55-64
23735482-9	2013	Moreover, quercetin arrested Src, PI3K, PDK1 and Akt activation in a time- and dose-dependent manner, which was comparable to PP2 and LY294002 inhibition of Src, PI3K/Akt and iNOS expressions.	Quercetin	10-19	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	40-44
23735482-9	2013	Moreover, quercetin arrested Src, PI3K, PDK1 and Akt activation in a time- and dose-dependent manner, which was comparable to PP2 and LY294002 inhibition of Src, PI3K/Akt and iNOS expressions.	Quercetin	10-19	thymoma viral proto-oncogene 1	Mus musculus	49-52
23735482-6	2013	Quercetin inhibited LPS-induced NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and GM-CSF mRNA and protein expressions while it promoted HO-1 induction in a dose- and time-dependent manner.	Quercetin	0-9	interleukin 1 beta	Mus musculus	66-74
23735482-9	2013	Moreover, quercetin arrested Src, PI3K, PDK1 and Akt activation in a time- and dose-dependent manner, which was comparable to PP2 and LY294002 inhibition of Src, PI3K/Akt and iNOS expressions.	Quercetin	10-19	thymoma viral proto-oncogene 1	Mus musculus	167-170
23735482-9	2013	Moreover, quercetin arrested Src, PI3K, PDK1 and Akt activation in a time- and dose-dependent manner, which was comparable to PP2 and LY294002 inhibition of Src, PI3K/Akt and iNOS expressions.	Quercetin	10-19	nitric oxide synthase 2, inducible	Mus musculus	175-179
23735482-6	2013	Quercetin inhibited LPS-induced NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and GM-CSF mRNA and protein expressions while it promoted HO-1 induction in a dose- and time-dependent manner.	Quercetin	0-9	interleukin 6	Mus musculus	76-80
23735482-10	2013	Quercetin further arrested Src and Syk tyrosine phosphorylations and their kinase activities followed by inhibition of PI3K tyrosine phosphorylation.	Quercetin	0-9	Rous sarcoma oncogene	Mus musculus	27-30
23735482-6	2013	Quercetin inhibited LPS-induced NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and GM-CSF mRNA and protein expressions while it promoted HO-1 induction in a dose- and time-dependent manner.	Quercetin	0-9	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	85-91
24368982-11	2013	Treatment with quercetin also increased the expression of Grp78/Bip and GADD153/CHOP protein and induced mitochondrial dysfunction.	Quercetin	15-24	heat shock protein family A (Hsp70) member 5	Homo sapiens	58-63
23735482-10	2013	Quercetin further arrested Src and Syk tyrosine phosphorylations and their kinase activities followed by inhibition of PI3K tyrosine phosphorylation.	Quercetin	0-9	spleen tyrosine kinase	Mus musculus	35-38
23735482-11	2013	Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation.	Quercetin	10-19	extracellular matrix protein 1	Mus musculus	42-45
23735482-11	2013	Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation.	Quercetin	10-19	toll-like receptor 4	Mus musculus	61-65
23735482-11	2013	Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation.	Quercetin	10-19	myeloid differentiation primary response gene 88	Mus musculus	66-71
23735482-11	2013	Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation.	Quercetin	10-19	interleukin-1 receptor-associated kinase 1	Mus musculus	114-119
23735482-11	2013	Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation.	Quercetin	10-19	TNF receptor-associated factor 6	Mus musculus	121-126
23735482-11	2013	Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation.	Quercetin	10-19	mitogen-activated protein kinase kinase kinase 7	Mus musculus	131-135
23735482-11	2013	Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation.	Quercetin	10-19	mitogen-activated protein kinase 14	Mus musculus	167-170
23735482-11	2013	Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation.	Quercetin	10-19	mitogen-activated protein kinase 8	Mus musculus	175-178
23735482-11	2013	Moreover, quercetin disrupted LPS-induced p85 association to TLR4/MyD88 complex and it then limited activation of IRAK1, TRAF6 and TAK1 with a subsequent reduction in p38 and JNK activations, and suppression in IKKalpha/beta-mediated I-kappaB phosphorylation.	Quercetin	10-19	conserved helix-loop-helix ubiquitous kinase	Mus musculus	211-219
23735482-12	2013	Quercetin limits LPS-induced inflammation via inhibition of Src- and Syk-mediated PI3K-(p85) tyrosine phosphorylation and subsequent TLR4/MyD88/PI3K complex formation that limits activation of downstream signaling pathways.	Quercetin	0-9	Rous sarcoma oncogene	Mus musculus	60-63
23735482-12	2013	Quercetin limits LPS-induced inflammation via inhibition of Src- and Syk-mediated PI3K-(p85) tyrosine phosphorylation and subsequent TLR4/MyD88/PI3K complex formation that limits activation of downstream signaling pathways.	Quercetin	0-9	spleen tyrosine kinase	Mus musculus	69-72
23735482-12	2013	Quercetin limits LPS-induced inflammation via inhibition of Src- and Syk-mediated PI3K-(p85) tyrosine phosphorylation and subsequent TLR4/MyD88/PI3K complex formation that limits activation of downstream signaling pathways.	Quercetin	0-9	extracellular matrix protein 1	Mus musculus	88-91
23735482-12	2013	Quercetin limits LPS-induced inflammation via inhibition of Src- and Syk-mediated PI3K-(p85) tyrosine phosphorylation and subsequent TLR4/MyD88/PI3K complex formation that limits activation of downstream signaling pathways.	Quercetin	0-9	toll-like receptor 4	Mus musculus	133-137
24368982-11	2013	Treatment with quercetin also increased the expression of Grp78/Bip and GADD153/CHOP protein and induced mitochondrial dysfunction.	Quercetin	15-24	heat shock protein family A (Hsp70) member 5	Homo sapiens	64-67
24368982-11	2013	Treatment with quercetin also increased the expression of Grp78/Bip and GADD153/CHOP protein and induced mitochondrial dysfunction.	Quercetin	15-24	DNA damage inducible transcript 3	Homo sapiens	72-79
24368982-11	2013	Treatment with quercetin also increased the expression of Grp78/Bip and GADD153/CHOP protein and induced mitochondrial dysfunction.	Quercetin	15-24	DNA damage inducible transcript 3	Homo sapiens	80-84
24353828-0	2013	Anticarcinogenic effect of quercetin by inhibition of insulin-like growth factor (IGF)-1 signaling in mouse skin cancer.	Quercetin	27-36	insulin-like growth factor 1	Mus musculus	54-88
23933436-9	2013	These results suggest that quercetin inhibits glutamate release from rat cortical synaptosomes and this effect is linked to a decrease in presynaptic voltage-dependent Ca(2+) entry and to the suppression of PKC and PKA activity.	Quercetin	27-36	protein kinase C, gamma	Rattus norvegicus	207-210
23933436-9	2013	These results suggest that quercetin inhibits glutamate release from rat cortical synaptosomes and this effect is linked to a decrease in presynaptic voltage-dependent Ca(2+) entry and to the suppression of PKC and PKA activity.	Quercetin	27-36	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	215-218
23933436-6	2013	The quercetin-mediated inhibition of glutamate release was prevented by blocking the Cav2.2 (N-type) and Cav2.1 (P/Q-type) channels, but not by blocking intracellular Ca(2+) release.	Quercetin	4-13	calcium voltage-gated channel subunit alpha1 A	Rattus norvegicus	105-111
23933436-7	2013	Combined inhibition of protein kinase C (PKC) and protein kinase A (PKA) also prevented the inhibitory effect of quercetin on evoked glutamate release.	Quercetin	113-122	protein kinase C, gamma	Rattus norvegicus	23-39
23933436-7	2013	Combined inhibition of protein kinase C (PKC) and protein kinase A (PKA) also prevented the inhibitory effect of quercetin on evoked glutamate release.	Quercetin	113-122	protein kinase C, gamma	Rattus norvegicus	41-44
23933436-7	2013	Combined inhibition of protein kinase C (PKC) and protein kinase A (PKA) also prevented the inhibitory effect of quercetin on evoked glutamate release.	Quercetin	113-122	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	50-66
24353828-6	2013	Further analysis of the MT1/2 skin papilloma cell line showed that a quercetin treatment dose dependently suppressed IGF-1 induced phosphorylation of the IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1, Akt and S6K; however, had no effect on the phosphorylation of PTEN.	Quercetin	69-78	metallothionein 1	Mus musculus	24-29
23933436-7	2013	Combined inhibition of protein kinase C (PKC) and protein kinase A (PKA) also prevented the inhibitory effect of quercetin on evoked glutamate release.	Quercetin	113-122	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	68-71
23933436-8	2013	Furthermore, quercetin decreased the 4-AP-induced phosphorylation of PKC and PKA.	Quercetin	13-22	protein kinase C, gamma	Rattus norvegicus	69-72
24353828-6	2013	Further analysis of the MT1/2 skin papilloma cell line showed that a quercetin treatment dose dependently suppressed IGF-1 induced phosphorylation of the IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1, Akt and S6K; however, had no effect on the phosphorylation of PTEN.	Quercetin	69-78	insulin-like growth factor 1	Mus musculus	117-122
23933436-8	2013	Furthermore, quercetin decreased the 4-AP-induced phosphorylation of PKC and PKA.	Quercetin	13-22	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	77-80
24353828-6	2013	Further analysis of the MT1/2 skin papilloma cell line showed that a quercetin treatment dose dependently suppressed IGF-1 induced phosphorylation of the IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1, Akt and S6K; however, had no effect on the phosphorylation of PTEN.	Quercetin	69-78	insulin-like growth factor I receptor	Mus musculus	154-168
24353828-6	2013	Further analysis of the MT1/2 skin papilloma cell line showed that a quercetin treatment dose dependently suppressed IGF-1 induced phosphorylation of the IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1, Akt and S6K; however, had no effect on the phosphorylation of PTEN.	Quercetin	69-78	insulin-like growth factor I receptor	Mus musculus	170-176
24353828-6	2013	Further analysis of the MT1/2 skin papilloma cell line showed that a quercetin treatment dose dependently suppressed IGF-1 induced phosphorylation of the IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1, Akt and S6K; however, had no effect on the phosphorylation of PTEN.	Quercetin	69-78	insulin receptor substrate 1	Mus musculus	179-213
24353828-6	2013	Further analysis of the MT1/2 skin papilloma cell line showed that a quercetin treatment dose dependently suppressed IGF-1 induced phosphorylation of the IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1, Akt and S6K; however, had no effect on the phosphorylation of PTEN.	Quercetin	69-78	thymoma viral proto-oncogene 1	Mus musculus	215-218
24353828-6	2013	Further analysis of the MT1/2 skin papilloma cell line showed that a quercetin treatment dose dependently suppressed IGF-1 induced phosphorylation of the IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1, Akt and S6K; however, had no effect on the phosphorylation of PTEN.	Quercetin	69-78	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	223-226
24353828-6	2013	Further analysis of the MT1/2 skin papilloma cell line showed that a quercetin treatment dose dependently suppressed IGF-1 induced phosphorylation of the IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1, Akt and S6K; however, had no effect on the phosphorylation of PTEN.	Quercetin	69-78	phosphatase and tensin homolog	Mus musculus	277-281
24353828-7	2013	Additionally, the quercetin treatment inhibited IGF-1 stimulated cell proliferation in a dose dependent manner.	Quercetin	18-27	insulin-like growth factor 1	Mus musculus	48-53
24353828-8	2013	Taken together, these data suggest that quercetin has a potent anticancer activity through the inhibition of IGF-1 signaling.	Quercetin	40-49	insulin-like growth factor 1	Mus musculus	109-114
24216107-4	2013	We found that quercetin-3-O-glucuronide (Q3GA), a major quercetin metabolite after absorption from the digestive tract, enhanced ABCA1 expression, in vitro, via LXRalpha in macrophages.	Quercetin	14-23	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	129-134
24892140-0	2013	Modulatory effects of quercetin and rutin on the activity, expression and inducibility of CYP1A1 in intestinal HCT-8 cells.	Quercetin	22-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	90-96
24210099-5	2013	Downregulation of Hsp70 by the specific chaperone inhibitor Quercetin or RNA interference and upregulation of Hsp70 by expression from a recombinant adenovirus showed that Hsp70 enhanced PCV2 genome replication and virion production.	Quercetin	60-69	heat shock protein family A (Hsp70) member 4	Homo sapiens	18-23
24216107-4	2013	We found that quercetin-3-O-glucuronide (Q3GA), a major quercetin metabolite after absorption from the digestive tract, enhanced ABCA1 expression, in vitro, via LXRalpha in macrophages.	Quercetin	14-23	nuclear receptor subfamily 1, group H, member 3	Mus musculus	161-169
24260470-5	2013	Our results show that quercetin significantly attenuates LPS-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW264.7 macrophages.	Quercetin	22-31	tumor necrosis factor	Mus musculus	83-110
24260470-5	2013	Our results show that quercetin significantly attenuates LPS-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW264.7 macrophages.	Quercetin	22-31	tumor necrosis factor	Mus musculus	112-121
24260470-5	2013	Our results show that quercetin significantly attenuates LPS-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW264.7 macrophages.	Quercetin	22-31	interleukin 1 beta	Mus musculus	127-144
24260470-5	2013	Our results show that quercetin significantly attenuates LPS-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW264.7 macrophages.	Quercetin	22-31	interleukin 1 beta	Mus musculus	146-154
24260470-6	2013	The LPS-stimulated phosphorylations of the inhibitors of kappaB kinase (IKKs), Akt, and c-Jun N-terminal kinase (JNK) are also inhibited by quercetin.	Quercetin	140-149	thymoma viral proto-oncogene 1	Mus musculus	79-82
24260470-6	2013	The LPS-stimulated phosphorylations of the inhibitors of kappaB kinase (IKKs), Akt, and c-Jun N-terminal kinase (JNK) are also inhibited by quercetin.	Quercetin	140-149	mitogen-activated protein kinase 8	Mus musculus	88-111
24260470-6	2013	The LPS-stimulated phosphorylations of the inhibitors of kappaB kinase (IKKs), Akt, and c-Jun N-terminal kinase (JNK) are also inhibited by quercetin.	Quercetin	140-149	mitogen-activated protein kinase 8	Mus musculus	113-116
24260470-7	2013	Quercetin causes a significant reduction in the phosphorylation and degradation of inhibitor of kappaBalpha (IkappaBalpha) and in the nuclear level of nuclear factor-kappaB (NF-kappaB), the latter being associated with decreased NF-kappaB binding activity.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	109-121
24260470-8	2013	Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels.	Quercetin	42-51	tumor necrosis factor	Mus musculus	105-114
24260470-8	2013	Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels.	Quercetin	42-51	interleukin 1 beta	Mus musculus	119-127
24260470-8	2013	Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels.	Quercetin	42-51	tumor necrosis factor	Mus musculus	269-278
24260470-8	2013	Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels.	Quercetin	42-51	interleukin 1 beta	Mus musculus	283-291
24260470-8	2013	Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels.	Quercetin	223-232	tumor necrosis factor	Mus musculus	269-278
24260470-8	2013	Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels.	Quercetin	223-232	interleukin 1 beta	Mus musculus	283-291
24260490-9	2013	The deconjugated aglycone, quercetin, acts as an anti-inflammatory agent in the stimulated macrophages by inhibiting the c-Jun N-terminal kinase activation, whereas Q3GA acts only in the presence of extracellular beta-glucuronidase activity.	Quercetin	27-36	glucuronidase beta	Homo sapiens	213-231
24117263-6	2013	Furthermore, overexpression of transforming growth factor beta1 (TGF-beta1), connective tissue growth factor (CTGF), and excessive deposition of extracellular matrix (ECM) in isoproterenol-treated myocardial tissues were normalized by quercetin and rutin.	Quercetin	235-244	transforming growth factor, beta 1	Rattus norvegicus	31-63
24244355-7	2013	PFT-mu decreased the viabilities of all cell lines at one-tenth the dose of Quercetin, a well-known HSP inhibitor.	Quercetin	76-85	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	100-103
24117263-6	2013	Furthermore, overexpression of transforming growth factor beta1 (TGF-beta1), connective tissue growth factor (CTGF), and excessive deposition of extracellular matrix (ECM) in isoproterenol-treated myocardial tissues were normalized by quercetin and rutin.	Quercetin	235-244	transforming growth factor, beta 1	Rattus norvegicus	65-74
24117263-5	2013	The administration of quercetin and rutin signifcantly decreased the cardiac weight index and myocardial enzyme activity, increased the activity of superoxide dismutase in the serum, and inhibited the ISO-induced increase in angiotensin II and aldosterone in the plasma.	Quercetin	22-31	angiotensinogen	Rattus norvegicus	225-239
24117263-6	2013	Furthermore, overexpression of transforming growth factor beta1 (TGF-beta1), connective tissue growth factor (CTGF), and excessive deposition of extracellular matrix (ECM) in isoproterenol-treated myocardial tissues were normalized by quercetin and rutin.	Quercetin	235-244	cellular communication network factor 2	Rattus norvegicus	77-108
24312717-11	2013	Treatment with either gemcitabine or quercetin augmented caspase-3 activity in both cell lines, and a combination of these compounds further potentiated caspase-3 activity.	Quercetin	37-46	caspase 3	Homo sapiens	57-66
24312717-14	2013	CONCLUSIONS: Modulation of HSP 70 expression with quercetin enhanced the chemoresponsiveness of PCCs to gemcitabine.	Quercetin	50-59	heat shock protein family A (Hsp70) member 4	Homo sapiens	27-33
24076371-0	2013	Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-kappaB pathway and activating the Nrf2-dependent HO-1 pathway.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	150-154
24076371-5	2013	Here, we found that quercetin significantly suppressed LPS-induced NO production and inducible NO synthase (iNOS) expression.	Quercetin	20-29	nitric oxide synthase 2, inducible	Mus musculus	85-106
24076371-5	2013	Here, we found that quercetin significantly suppressed LPS-induced NO production and inducible NO synthase (iNOS) expression.	Quercetin	20-29	nitric oxide synthase 2, inducible	Mus musculus	108-112
24076371-6	2013	Notably, quercetin inhibited nuclear factor-kappaB (NF-kappaB) activation by inhibiting degradation of the inhibitor of kappa Balpha (IkappaBalpha) in LPS-stimulated BV2 microglial cells corresponding to the inhibitory effect of specific NF-kappaB inhibitors, namely proteasome inhibitor I (PSI) and MG132.	Quercetin	9-18	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	134-146
24076371-7	2013	Quercetin caused significant increases in the levels of heme oxgenase-1 (HO-1) mRNA and protein.	Quercetin	0-9	heme oxygenase 1	Mus musculus	56-77
24076371-9	2013	Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression.	Quercetin	14-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
24076371-9	2013	Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression.	Quercetin	204-213	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
23679081-7	2013	The inhibition of HSP70 using quercetin resulted in an elevation of JNK activity by decreasing the cytoplasmic solubility of M3/6.	Quercetin	30-39	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	18-23
23679081-7	2013	The inhibition of HSP70 using quercetin resulted in an elevation of JNK activity by decreasing the cytoplasmic solubility of M3/6.	Quercetin	30-39	mitogen-activated protein kinase 8	Rattus norvegicus	68-71
24076371-9	2013	Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression.	Quercetin	204-213	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
24076371-9	2013	Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression.	Quercetin	204-213	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
24076371-9	2013	Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression.	Quercetin	204-213	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
24076371-9	2013	Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression.	Quercetin	204-213	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
24076371-9	2013	Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression.	Quercetin	204-213	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
24076371-10	2013	Therefore, quercetin has the potential to decrease nitrosative stress by suppressing NF-kappaB activation and inducing Nrf2-mediated HO-1 expression.	Quercetin	11-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
24331699-6	2013	CONCLUSION: Quercetin may induce HO-1 expression via the ERK/Nrf2 signaling transduction pathway.	Quercetin	12-21	heme oxygenase 1	Rattus norvegicus	33-37
24331699-6	2013	CONCLUSION: Quercetin may induce HO-1 expression via the ERK/Nrf2 signaling transduction pathway.	Quercetin	12-21	Eph receptor B1	Rattus norvegicus	57-60
24331699-0	2013	[Potential molecular mechanisms of quercetin-induced heme oxygenase-1 in rat primary hepatocytes].	Quercetin	35-44	heme oxygenase 1	Rattus norvegicus	53-69
24331699-6	2013	CONCLUSION: Quercetin may induce HO-1 expression via the ERK/Nrf2 signaling transduction pathway.	Quercetin	12-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	61-65
24331699-1	2013	OBJECTIVE: To investigate the possible molecular mechanisms of heme oxygenase-1 (HO-1) induction by quercetin using rat primary hepatocytes.	Quercetin	100-109	heme oxygenase 1	Rattus norvegicus	63-79
23692748-7	2013	By correlation analysis, the compounds showing the strongest association with TF-inhibiting activity were quercetin and cyanidin.	Quercetin	106-115	coagulation factor III, tissue factor	Homo sapiens	78-80
24331699-1	2013	OBJECTIVE: To investigate the possible molecular mechanisms of heme oxygenase-1 (HO-1) induction by quercetin using rat primary hepatocytes.	Quercetin	100-109	heme oxygenase 1	Rattus norvegicus	81-85
24331699-4	2013	RESULTS: After 4 - 12 h of treatment with quercetin at all concentrations, the HO-1 mRNA level in hepatocytes had increased significantly (vs. untreated control cells; all P less than 0.01).	Quercetin	42-51	heme oxygenase 1	Rattus norvegicus	79-83
24331699-5	2013	The quercetin-induced HO-1 expression and Nrf2 translocation into the nucleolus was inhibited by PD98059.	Quercetin	4-13	heme oxygenase 1	Rattus norvegicus	22-26
24331699-5	2013	The quercetin-induced HO-1 expression and Nrf2 translocation into the nucleolus was inhibited by PD98059.	Quercetin	4-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	42-46
23997041-5	2013	However, simultaneous supplementation with quercetin (75 mg/kg) attenuated the toxicity induced by PNP through renewal of the antioxidant enzyme"s status, alleviating apoptosis by regulating the expressions of Bax and Bcl-xl, XBP-1 and HO-1mRNAs, and the regulation of caspase-3 activity.	Quercetin	43-52	BCL2-associated X protein	Mus musculus	210-213
24151360-8	2013	Quercetin induced a VIP-IR and glial cells areas (P &lt; 0.001) in DQ group when compared to C, CQ and D groups.	Quercetin	0-9	vasoactive intestinal peptide	Rattus norvegicus	20-23
23931732-1	2013	LY294002 is a synthetic quercetin-like compound, which, unlike wortmannin, is more specific inhibitor of phosphatidylinositol 3-kinase (PI3K).	Quercetin	24-33	vacuolar protein sorting 34	Arabidopsis thaliana	105-134
23997041-5	2013	However, simultaneous supplementation with quercetin (75 mg/kg) attenuated the toxicity induced by PNP through renewal of the antioxidant enzyme"s status, alleviating apoptosis by regulating the expressions of Bax and Bcl-xl, XBP-1 and HO-1mRNAs, and the regulation of caspase-3 activity.	Quercetin	43-52	BCL2-like 1	Mus musculus	218-224
23997041-5	2013	However, simultaneous supplementation with quercetin (75 mg/kg) attenuated the toxicity induced by PNP through renewal of the antioxidant enzyme"s status, alleviating apoptosis by regulating the expressions of Bax and Bcl-xl, XBP-1 and HO-1mRNAs, and the regulation of caspase-3 activity.	Quercetin	43-52	X-box binding protein 1	Mus musculus	226-231
23997041-5	2013	However, simultaneous supplementation with quercetin (75 mg/kg) attenuated the toxicity induced by PNP through renewal of the antioxidant enzyme"s status, alleviating apoptosis by regulating the expressions of Bax and Bcl-xl, XBP-1 and HO-1mRNAs, and the regulation of caspase-3 activity.	Quercetin	43-52	caspase 3	Mus musculus	269-278
23900432-3	2013	Thus, the objective of this study was to examine the biological activities of quercetin against mammary cancer cells, and to determine whether quercetin could regulate the Wnt/beta-catenin signaling pathway.	Quercetin	143-152	catenin (cadherin associated protein), beta 1	Mus musculus	176-188
24068165-0	2013	Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
23900432-6	2013	Moreover, the inhibitory effect of quercetin on the Wnt/beta-catenin signaling pathway was confirmed by the reduced stabilization of the beta-catenin protein.	Quercetin	35-44	catenin (cadherin associated protein), beta 1	Mus musculus	56-68
23900432-6	2013	Moreover, the inhibitory effect of quercetin on the Wnt/beta-catenin signaling pathway was confirmed by the reduced stabilization of the beta-catenin protein.	Quercetin	35-44	catenin (cadherin associated protein), beta 1	Mus musculus	137-149
23900432-7	2013	Among various antagonists screened for the Wnt/beta-catenin signaling pathway, the expression of DKK1, 2 and 3 was induced after treatment with 20 microM of quercetin.	Quercetin	157-166	catenin (cadherin associated protein), beta 1	Mus musculus	47-59
23900432-7	2013	Among various antagonists screened for the Wnt/beta-catenin signaling pathway, the expression of DKK1, 2 and 3 was induced after treatment with 20 microM of quercetin.	Quercetin	157-166	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	97-110
23900432-8	2013	Stimulation with recombinant DKK1 protein, showed suppressive cell growth of mammary cancer cells instead of quercetin.	Quercetin	109-118	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	29-33
23900432-9	2013	When 4T1 cells were treated with recombinant Wnt3a or LiCl along with quercetin, both stimulators for the Wnt/beta-catenin signaling pathway were able to restore the suppressed cell viability by quercetin.	Quercetin	70-79	wingless-type MMTV integration site family, member 3A	Mus musculus	45-50
23900432-9	2013	When 4T1 cells were treated with recombinant Wnt3a or LiCl along with quercetin, both stimulators for the Wnt/beta-catenin signaling pathway were able to restore the suppressed cell viability by quercetin.	Quercetin	70-79	catenin (cadherin associated protein), beta 1	Mus musculus	110-122
23900432-9	2013	When 4T1 cells were treated with recombinant Wnt3a or LiCl along with quercetin, both stimulators for the Wnt/beta-catenin signaling pathway were able to restore the suppressed cell viability by quercetin.	Quercetin	195-204	wingless-type MMTV integration site family, member 3A	Mus musculus	45-50
23900432-9	2013	When 4T1 cells were treated with recombinant Wnt3a or LiCl along with quercetin, both stimulators for the Wnt/beta-catenin signaling pathway were able to restore the suppressed cell viability by quercetin.	Quercetin	195-204	catenin (cadherin associated protein), beta 1	Mus musculus	110-122
23900432-10	2013	Thus, our data suggest that quercetin exerts its anticancer activity through the downregulation of Wnt/beta-catenin signaling activity.	Quercetin	28-37	catenin (cadherin associated protein), beta 1	Mus musculus	103-115
23900432-11	2013	These results indicate for the first time that quercetin decreases cell viability and induces apoptosis in murine mammary cancer cells, which is possibly mediated by DKK-dependent inhibition of the Wnt/beta-catenin signaling pathway.	Quercetin	47-56	catenin (cadherin associated protein), beta 1	Mus musculus	202-214
23900432-12	2013	In conclusion, our findings suggest that quercetin has great potential value as chemotherapeutic agent for cancer treatment, especially in breast cancer controlled by Wnt/beta-catenin signaling activity.	Quercetin	41-50	catenin (cadherin associated protein), beta 1	Mus musculus	171-183
24148954-14	2013	The lead acetate + quercetin group had higher Cu/Zn SOD activity and CP content in the hippocampus than the lead acetate group (P &lt; 0.05).	Quercetin	19-28	superoxide dismutase 1	Rattus norvegicus	46-55
22137869-4	2013	Here, we investigated the quercetin effect on the E-NTPDases and ecto-5"-nucleotidase/CD73, which catalyzes the introversion of the extracellular purine nucleotides in T24 human bladder cancer cells.	Quercetin	26-35	5'-nucleotidase ecto	Homo sapiens	65-85
22137869-4	2013	Here, we investigated the quercetin effect on the E-NTPDases and ecto-5"-nucleotidase/CD73, which catalyzes the introversion of the extracellular purine nucleotides in T24 human bladder cancer cells.	Quercetin	26-35	5'-nucleotidase ecto	Homo sapiens	86-90
24148954-14	2013	The lead acetate + quercetin group had higher Cu/Zn SOD activity and CP content in the hippocampus than the lead acetate group (P &lt; 0.05).	Quercetin	19-28	ceruloplasmin	Rattus norvegicus	69-71
24098781-0	2013	Attenuation of chondrogenic transformation in vascular smooth muscle by dietary quercetin in the MGP-deficient mouse model.	Quercetin	80-89	matrix Gla protein	Mus musculus	97-100
24098781-5	2013	Quercetin intercepted chondrogenic transformation of VSM and blocked activation of beta-catenin both in vivo and in vitro.	Quercetin	0-9	catenin (cadherin associated protein), beta 1	Mus musculus	83-95
24098781-6	2013	Although dietary quercetin drastically attenuated calcifying cartilaginous metaplasia in Mgp-/- animals, approximately one-half of total vascular calcium mineral remained as depositions along elastic lamellae.	Quercetin	17-26	matrix Gla protein	Mus musculus	89-92
24098781-8	2013	Combined with the demonstrated efficiency of dietary quercetin in preventing ectopic chondrogenesis in the MGP-null vasculature, these findings indicate a potentially broad therapeutic applicability of this safe for human consumption bioflavonoid in the therapy of cardiovascular conditions linked to cartilaginous metaplasia of VSM.	Quercetin	53-62	matrix Gla protein	Homo sapiens	107-110
24044691-0	2013	Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum.	Quercetin	19-28	fatty acid synthase	Homo sapiens	43-62
24044691-16	2013	Trans-chalcone and quercetin inhibited the enzymatic activity of FAS, with IC50 values of 68.23 and 17.1 mug/mL, respectively.	Quercetin	19-28	fatty acid synthase	Homo sapiens	65-68
23272907-0	2013	Inhibition of mTOR signaling by quercetin in cancer treatment and prevention.	Quercetin	32-41	mechanistic target of rapamycin kinase	Homo sapiens	14-18
23856525-14	2013	The increased cytotoxicity of the studied ANPs found in OAT1 transfected cells was effectively reduced by OAT inhibitors probenecid and quercetin.	Quercetin	136-145	solute carrier family 22 member 6	Homo sapiens	56-60
24039778-9	2013	Furthermore, western blotting and real time-PCR analyses also showed that transfection with PPAR-gamma siRNA significantly increased AP-1 signaling and reversed the effects of quercetin inhibition on mRNA expression levels of genes such as ANP and BNP in hypertrophic H9C2 cells.	Quercetin	176-185	natriuretic peptide B	Rattus norvegicus	248-251
24039778-10	2013	CONCLUSIONS: Our data indicate that quercetin may inhibit cardiac hypertrophy by enhancing PPAR-gamma expression and by suppressing the AP-1 signaling pathway.	Quercetin	36-45	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	91-101
24039778-10	2013	CONCLUSIONS: Our data indicate that quercetin may inhibit cardiac hypertrophy by enhancing PPAR-gamma expression and by suppressing the AP-1 signaling pathway.	Quercetin	36-45	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	136-140
23770986-0	2013	Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-kappaB inhibition.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	105-110
23770986-7	2013	Co-treatment with quercetin (2.5, 5, and 10 mmol/L) dose-dependently decreased HG-induced caspase-3 activation and apoptosis.	Quercetin	18-27	caspase 3	Rattus norvegicus	90-99
23770986-8	2013	Quercetin could directly scavenge ROS and significantly increased the expression of Nrf-2 and HO-1 in DRG neurons.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	84-89
23770986-9	2013	Quercetin also dose-dependently inhibited the NF-kappaB signaling pathway and suppressed the expression of iNOS, COX-2, and proinflammatory cytokines IL-6 and TNF-alpha.	Quercetin	0-9	nitric oxide synthase 2	Rattus norvegicus	107-111
23770986-9	2013	Quercetin also dose-dependently inhibited the NF-kappaB signaling pathway and suppressed the expression of iNOS, COX-2, and proinflammatory cytokines IL-6 and TNF-alpha.	Quercetin	0-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	113-118
23770986-9	2013	Quercetin also dose-dependently inhibited the NF-kappaB signaling pathway and suppressed the expression of iNOS, COX-2, and proinflammatory cytokines IL-6 and TNF-alpha.	Quercetin	0-9	interleukin 6	Rattus norvegicus	150-154
23770986-9	2013	Quercetin also dose-dependently inhibited the NF-kappaB signaling pathway and suppressed the expression of iNOS, COX-2, and proinflammatory cytokines IL-6 and TNF-alpha.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	159-168
23770986-10	2013	CONCLUSION: Quercetin protects rat DRG neurons against HG-induced injury in vitro through Nrf-2/HO-1 activation and NF-kappaB inhibition, thus may be beneficial for the treatment of diabetic neuropathy.	Quercetin	12-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	90-95
23947593-0	2013	Human metabolic transformation of quercetin blocks its capacity to decrease endothelial nitric oxide synthase (eNOS) expression and endothelin-1 secretion by human endothelial cells.	Quercetin	34-43	nitric oxide synthase 3	Homo sapiens	76-109
23947593-0	2013	Human metabolic transformation of quercetin blocks its capacity to decrease endothelial nitric oxide synthase (eNOS) expression and endothelin-1 secretion by human endothelial cells.	Quercetin	34-43	nitric oxide synthase 3	Homo sapiens	111-115
23947593-0	2013	Human metabolic transformation of quercetin blocks its capacity to decrease endothelial nitric oxide synthase (eNOS) expression and endothelin-1 secretion by human endothelial cells.	Quercetin	34-43	endothelin 1	Homo sapiens	132-144
23947593-2	2013	This study examined the relative abilities of quercetin and its human metabolites to modulate the expression of eNOS and ET-1, which are involved in regulating endothelial homeostasis.	Quercetin	46-55	nitric oxide synthase 3	Homo sapiens	112-116
23947593-2	2013	This study examined the relative abilities of quercetin and its human metabolites to modulate the expression of eNOS and ET-1, which are involved in regulating endothelial homeostasis.	Quercetin	46-55	endothelin 1	Homo sapiens	121-125
23947593-5	2013	ET-1 expression was significantly reduced by quercetin in both TNFalpha-stimulated or unstimulated HUVECs.	Quercetin	45-54	endothelin 1	Homo sapiens	0-4
23947593-5	2013	ET-1 expression was significantly reduced by quercetin in both TNFalpha-stimulated or unstimulated HUVECs.	Quercetin	45-54	tumor necrosis factor	Homo sapiens	63-71
23947593-7	2013	These results suggest that metabolic transformation of quercetin prevents it from causing a potentially deleterious decrease in eNOS in endothelial cells.	Quercetin	55-64	nitric oxide synthase 3	Homo sapiens	128-132
24039778-0	2013	Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-gamma expression and suppressing AP-1 activity.	Quercetin	0-9	angiotensinogen	Rattus norvegicus	96-110
24039778-0	2013	Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-gamma expression and suppressing AP-1 activity.	Quercetin	0-9	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	155-165
24039778-0	2013	Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-gamma expression and suppressing AP-1 activity.	Quercetin	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	193-197
24039778-2	2013	We hypothesized that quercetin inhibits cardiac hypertrophy by blocking AP-1 (c-fos, c-jun) and activating PPAR-gamma signaling pathways.	Quercetin	21-30	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-76
24039778-2	2013	We hypothesized that quercetin inhibits cardiac hypertrophy by blocking AP-1 (c-fos, c-jun) and activating PPAR-gamma signaling pathways.	Quercetin	21-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	78-83
24039778-2	2013	We hypothesized that quercetin inhibits cardiac hypertrophy by blocking AP-1 (c-fos, c-jun) and activating PPAR-gamma signaling pathways.	Quercetin	21-30	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	107-117
24039778-5	2013	In vitro, quercetin also significantly attenuated Ang II-induced H9C2 cells hypertrophy, as indicated by its concentration dependent inhibitory effects on [3H]leucine incorporation into H9C2 cells (64% reduction) and by the reduced hypertrophic surface area in H9C2 cells compared with the Ang II group (P&lt;0.01, vs. Ang II group).	Quercetin	10-19	angiogenin	Rattus norvegicus	50-53
24039778-5	2013	In vitro, quercetin also significantly attenuated Ang II-induced H9C2 cells hypertrophy, as indicated by its concentration dependent inhibitory effects on [3H]leucine incorporation into H9C2 cells (64% reduction) and by the reduced hypertrophic surface area in H9C2 cells compared with the Ang II group (P&lt;0.01, vs. Ang II group).	Quercetin	10-19	angiotensinogen	Rattus norvegicus	50-56
24039778-5	2013	In vitro, quercetin also significantly attenuated Ang II-induced H9C2 cells hypertrophy, as indicated by its concentration dependent inhibitory effects on [3H]leucine incorporation into H9C2 cells (64% reduction) and by the reduced hypertrophic surface area in H9C2 cells compared with the Ang II group (P&lt;0.01, vs. Ang II group).	Quercetin	10-19	angiotensinogen	Rattus norvegicus	290-296
24039778-6	2013	Concurrently, we found that PPAR-gamma activity was significantly increased in the quercetin-treated group both in vivo and in vitro when analyzed using immunofluorescent or immunohistochemical assays (P&lt;0.05, vs. SHRs or P&lt;0.01, vs. the Ang II group).	Quercetin	83-92	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	28-38
24039778-6	2013	Concurrently, we found that PPAR-gamma activity was significantly increased in the quercetin-treated group both in vivo and in vitro when analyzed using immunofluorescent or immunohistochemical assays (P&lt;0.05, vs. SHRs or P&lt;0.01, vs. the Ang II group).	Quercetin	83-92	angiotensinogen	Rattus norvegicus	244-250
24039778-7	2013	Conversely, in vivo, AP-1 (c-fos, s-jun) activation was suppressed in the quercetin-treated group, as was the downstream hypertrophy gene, including mRNA levels of ANP and BNP (P&lt;0.05, vs. SHRs).	Quercetin	74-83	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-25
24039778-7	2013	Conversely, in vivo, AP-1 (c-fos, s-jun) activation was suppressed in the quercetin-treated group, as was the downstream hypertrophy gene, including mRNA levels of ANP and BNP (P&lt;0.05, vs. SHRs).	Quercetin	74-83	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-32
24039778-7	2013	Conversely, in vivo, AP-1 (c-fos, s-jun) activation was suppressed in the quercetin-treated group, as was the downstream hypertrophy gene, including mRNA levels of ANP and BNP (P&lt;0.05, vs. SHRs).	Quercetin	74-83	natriuretic peptide B	Rattus norvegicus	172-175
24039778-8	2013	Additionally, both western blotting and real time-PCR demonstrated that PPAR-gamma protein and mRNA were increased in the myocardium and AP-1 protein and mRNA were significantly decreased in the quercetin-treated group (P&lt;0.05, vs. SHRs).	Quercetin	195-204	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	137-141
24039778-9	2013	Furthermore, western blotting and real time-PCR analyses also showed that transfection with PPAR-gamma siRNA significantly increased AP-1 signaling and reversed the effects of quercetin inhibition on mRNA expression levels of genes such as ANP and BNP in hypertrophic H9C2 cells.	Quercetin	176-185	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	92-102
23873842-0	2013	Quercetin acutely relaxes airway smooth muscle and potentiates beta-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCbeta and PDE4.	Quercetin	0-9	phospholipase C, beta 1	Mus musculus	136-143
23272907-4	2013	Among these, recent data reveal that quercetin can inhibit mTOR activity in cancer cells.	Quercetin	37-46	mechanistic target of rapamycin kinase	Homo sapiens	59-63
23272907-5	2013	Inhibition of the mTOR signaling pathway by quercetin has directly been described and can further be deduced from its interference with PI3K-dependent Akt stimulation, AMP-dependent protein kinase activation and hamartin upregulation.	Quercetin	44-53	mechanistic target of rapamycin kinase	Homo sapiens	18-22
23272907-5	2013	Inhibition of the mTOR signaling pathway by quercetin has directly been described and can further be deduced from its interference with PI3K-dependent Akt stimulation, AMP-dependent protein kinase activation and hamartin upregulation.	Quercetin	44-53	AKT serine/threonine kinase 1	Homo sapiens	151-154
23272907-5	2013	Inhibition of the mTOR signaling pathway by quercetin has directly been described and can further be deduced from its interference with PI3K-dependent Akt stimulation, AMP-dependent protein kinase activation and hamartin upregulation.	Quercetin	44-53	TSC complex subunit 1	Homo sapiens	212-220
23272907-6	2013	The ability of quercetin to interfere with both mTOR activity and activation of the PI3K/Akt signaling pathway gives quercetin the advantage to function as a dual-specific mTOR/PI3K inhibitor.	Quercetin	15-24	mechanistic target of rapamycin kinase	Homo sapiens	48-52
23272907-6	2013	The ability of quercetin to interfere with both mTOR activity and activation of the PI3K/Akt signaling pathway gives quercetin the advantage to function as a dual-specific mTOR/PI3K inhibitor.	Quercetin	15-24	AKT serine/threonine kinase 1	Homo sapiens	89-92
23272907-6	2013	The ability of quercetin to interfere with both mTOR activity and activation of the PI3K/Akt signaling pathway gives quercetin the advantage to function as a dual-specific mTOR/PI3K inhibitor.	Quercetin	15-24	mechanistic target of rapamycin kinase	Homo sapiens	172-176
23272907-6	2013	The ability of quercetin to interfere with both mTOR activity and activation of the PI3K/Akt signaling pathway gives quercetin the advantage to function as a dual-specific mTOR/PI3K inhibitor.	Quercetin	117-126	AKT serine/threonine kinase 1	Homo sapiens	89-92
23272907-6	2013	The ability of quercetin to interfere with both mTOR activity and activation of the PI3K/Akt signaling pathway gives quercetin the advantage to function as a dual-specific mTOR/PI3K inhibitor.	Quercetin	117-126	mechanistic target of rapamycin kinase	Homo sapiens	172-176
23272907-8	2013	The ability of quercetin to inhibit mTOR activity by multiple pathways makes this otherwise safe bioflavonoid an interesting tool for the treatment of cancers and other diseases associated with mTOR deregulation.	Quercetin	15-24	mechanistic target of rapamycin kinase	Homo sapiens	36-40
23272907-8	2013	The ability of quercetin to inhibit mTOR activity by multiple pathways makes this otherwise safe bioflavonoid an interesting tool for the treatment of cancers and other diseases associated with mTOR deregulation.	Quercetin	15-24	mechanistic target of rapamycin kinase	Homo sapiens	194-198
23758074-8	2013	On the other hand, increase in lucigenin CL, NO, MDA levels and MPO and caspase-3 activities and decrease in GSH levels and SOD activity in the cavernosal tissues of the I/R group were also significantly reversed by quercetin treatment.	Quercetin	216-225	myeloperoxidase	Rattus norvegicus	64-67
23809009-8	2013	The flavonols 3-Hydroxyflavone, galangin, quercetin and tamarixetin transactivated the ligand-binding domain of hCAR-WT, but only 3-hydroxyflavone recruited SRC-1, SRC-2 and SRC-3 to the receptor.	Quercetin	42-51	CXADR Ig-like cell adhesion molecule	Homo sapiens	112-116
23809009-8	2013	The flavonols 3-Hydroxyflavone, galangin, quercetin and tamarixetin transactivated the ligand-binding domain of hCAR-WT, but only 3-hydroxyflavone recruited SRC-1, SRC-2 and SRC-3 to the receptor.	Quercetin	42-51	nuclear receptor coactivator 2	Homo sapiens	164-169
23809009-8	2013	The flavonols 3-Hydroxyflavone, galangin, quercetin and tamarixetin transactivated the ligand-binding domain of hCAR-WT, but only 3-hydroxyflavone recruited SRC-1, SRC-2 and SRC-3 to the receptor.	Quercetin	42-51	nuclear receptor coactivator 3	Homo sapiens	174-179
23809009-7	2013	By comparison, 3-hydroxyflavone, galangin, datiscetin, kaempferol, quercetin, isorhamnetin and tamarixetin activated hCAR-WT, whereas none of the flavonols activated hCAR-SV25 (both SPTV and APYLT insertions).	Quercetin	67-76	CXADR Ig-like cell adhesion molecule	Homo sapiens	117-121
23758074-8	2013	On the other hand, increase in lucigenin CL, NO, MDA levels and MPO and caspase-3 activities and decrease in GSH levels and SOD activity in the cavernosal tissues of the I/R group were also significantly reversed by quercetin treatment.	Quercetin	216-225	caspase 3	Rattus norvegicus	72-81
25337554-0	2013	Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells.	Quercetin	0-9	sestrin 2	Homo sapiens	20-29
25337554-9	2013	On the other hand, the expression of Sestrin 2 by quercetin-generated intracellular ROS was independent of p53.	Quercetin	50-59	sestrin 2	Homo sapiens	37-46
25337554-10	2013	CONCLUSIONS: We suggested that quercetin-induced apoptosis involved Sestrin 2/AMPK/mTOR pathway, which was regulated by increased intracellular ROS by quercetin.	Quercetin	31-40	sestrin 2	Homo sapiens	68-77
25337554-0	2013	Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	30-34
25337554-10	2013	CONCLUSIONS: We suggested that quercetin-induced apoptosis involved Sestrin 2/AMPK/mTOR pathway, which was regulated by increased intracellular ROS by quercetin.	Quercetin	31-40	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	78-82
25337554-0	2013	Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	35-39
25337554-10	2013	CONCLUSIONS: We suggested that quercetin-induced apoptosis involved Sestrin 2/AMPK/mTOR pathway, which was regulated by increased intracellular ROS by quercetin.	Quercetin	31-40	mechanistic target of rapamycin kinase	Homo sapiens	83-87
25337554-10	2013	CONCLUSIONS: We suggested that quercetin-induced apoptosis involved Sestrin 2/AMPK/mTOR pathway, which was regulated by increased intracellular ROS by quercetin.	Quercetin	151-160	sestrin 2	Homo sapiens	68-77
25337554-2	2013	In this study, we investigated the regulatory mechanism of quercetin-induced apoptosis through regulation of Sestrin 2 and AMPK signaling pathway.	Quercetin	59-68	sestrin 2	Homo sapiens	109-118
25337554-10	2013	CONCLUSIONS: We suggested that quercetin-induced apoptosis involved Sestrin 2/AMPK/mTOR pathway, which was regulated by increased intracellular ROS by quercetin.	Quercetin	151-160	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	78-82
25337554-10	2013	CONCLUSIONS: We suggested that quercetin-induced apoptosis involved Sestrin 2/AMPK/mTOR pathway, which was regulated by increased intracellular ROS by quercetin.	Quercetin	151-160	mechanistic target of rapamycin kinase	Homo sapiens	83-87
25337554-2	2013	In this study, we investigated the regulatory mechanism of quercetin-induced apoptosis through regulation of Sestrin 2 and AMPK signaling pathway.	Quercetin	59-68	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	123-127
25337554-6	2013	RESULTS: Quercetin increased apoptotic cell death though generating intracellular reactive oxygen species (ROS), and it was responsible for Sestrin 2 expression.	Quercetin	9-18	sestrin 2	Homo sapiens	140-149
23634787-5	2013	RESULTS: When ROS were generated by ABAP, EC50 values for quercetin, epigallocatechin gallate (EGCG), n-propyl gallate, and gallic acid were 2.98, 3.41, 6.30, and 50.7 muM, respectively.	Quercetin	58-67	latexin	Homo sapiens	168-171
23618529-0	2013	Quercetin induces growth arrest through activation of FOXO1 transcription factor in EGFR-overexpressing oral cancer cells.	Quercetin	0-9	forkhead box O1	Mus musculus	54-59
23618529-0	2013	Quercetin induces growth arrest through activation of FOXO1 transcription factor in EGFR-overexpressing oral cancer cells.	Quercetin	0-9	epidermal growth factor receptor	Mus musculus	84-88
23618529-5	2013	Here, we hypothesized that FOXO1 might be crucial in quercetin-induced growth inhibition in EGFR-overexpressing oral cancer.	Quercetin	53-62	forkhead box O1	Mus musculus	27-32
23618529-5	2013	Here, we hypothesized that FOXO1 might be crucial in quercetin-induced growth inhibition in EGFR-overexpressing oral cancer.	Quercetin	53-62	epidermal growth factor receptor	Mus musculus	92-96
23618529-6	2013	Quercetin treatment suppressed cell growth by inducing G2 arrest and apoptosis in EGFR-overexpressing HSC-3 and TW206 oral cancer cells.	Quercetin	0-9	epidermal growth factor receptor	Mus musculus	82-86
23618529-7	2013	Quercetin inhibited EGFR/Akt activation with a concomitant induction of FOXO1 activation.	Quercetin	0-9	epidermal growth factor receptor	Mus musculus	20-24
23618529-7	2013	Quercetin inhibited EGFR/Akt activation with a concomitant induction of FOXO1 activation.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	25-28
23618529-7	2013	Quercetin inhibited EGFR/Akt activation with a concomitant induction of FOXO1 activation.	Quercetin	0-9	forkhead box O1	Mus musculus	72-77
23618529-8	2013	FOXO1 knockdown attenuated quercetin-induced p21 and FasL expression and subsequent G2 arrest and apoptosis, respectively.	Quercetin	27-36	forkhead box O1	Mus musculus	0-5
23618529-8	2013	FOXO1 knockdown attenuated quercetin-induced p21 and FasL expression and subsequent G2 arrest and apoptosis, respectively.	Quercetin	27-36	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	45-48
23618529-8	2013	FOXO1 knockdown attenuated quercetin-induced p21 and FasL expression and subsequent G2 arrest and apoptosis, respectively.	Quercetin	27-36	Fas ligand (TNF superfamily, member 6)	Mus musculus	53-57
23618529-10	2013	Taken together, our data indicate that quercetin is an effective anticancer agent and that FOXO1 is crucial in quercetin-induced growth suppression in EGFR-overexpressing oral cancer.	Quercetin	111-120	forkhead box O1	Mus musculus	91-96
23618529-10	2013	Taken together, our data indicate that quercetin is an effective anticancer agent and that FOXO1 is crucial in quercetin-induced growth suppression in EGFR-overexpressing oral cancer.	Quercetin	111-120	epidermal growth factor receptor	Mus musculus	151-155
23794501-3	2013	Eight major flavonoids (naringin, naringenin, hesperidin, hesperetin, phloridzin, phloretin, quercetin, and kaempferol) contained in the juices inhibited OATP2B1-mediated estrone-3-sulfate uptake with IC50 values of 4.63, 49.2, 1.92, 67.6, 23.2, 1.31, 9.47, and 21.3 muM, respectively.	Quercetin	93-102	solute carrier organic anion transporter family member 2B1 L homeolog	Xenopus laevis	154-161
23794501-6	2013	However, significant inhibition of OATP2B1 was observed with a mixture of phloridzin, phloretin, hesperidin, and quercetin at the concentrations present in AJ.	Quercetin	113-122	solute carrier organic anion transporter family member 2B1 L homeolog	Xenopus laevis	35-42
23743621-3	2013	The present study investigated whether quercetin could increase the levels of paraoxonase 2 (PON2), a mitochondrial enzyme expressed in brain cells, which has been shown to have potent antioxidant properties.	Quercetin	39-48	paraoxonase 2	Mus musculus	78-91
23743621-3	2013	The present study investigated whether quercetin could increase the levels of paraoxonase 2 (PON2), a mitochondrial enzyme expressed in brain cells, which has been shown to have potent antioxidant properties.	Quercetin	39-48	paraoxonase 2	Mus musculus	93-97
23743621-5	2013	Quercetin increased PON2 levels, possibly by activating the JNK/AP-1 pathway.	Quercetin	0-9	paraoxonase 2	Mus musculus	20-24
23743621-6	2013	The increased PON2 levels induced by quercetin resulted in decreased oxidative stress and ensuing toxicity induced by two oxidants.	Quercetin	37-46	paraoxonase 2	Mus musculus	14-18
23743621-7	2013	The neuroprotective effect of quercetin was significantly diminished in cells from PON2 knockout mice.	Quercetin	30-39	paraoxonase 2	Mus musculus	83-87
23743621-8	2013	These findings suggest that induction of PON2 by quercetin represents an important mechanism by which this polyphenol may exert its neuroprotective action.	Quercetin	49-58	paraoxonase 2	Mus musculus	41-45
23634787-6	2013	When ROS were generated extracellularly by xanthine oxidase, EC50 values for quercetin, EGCG, n-propyl gallate, and gallic acid were 41.3, 56.5, 70.5, and 337.5 muM.	Quercetin	77-86	latexin	Homo sapiens	161-164
23684917-2	2013	However, the effect of quercetin-3-O-(2""-galloyl)-alpha-l-rhamnopyranoside (QGR), a new quercetin derivative, on the tumor necrosis factor (TNF)-alpha-stimulated production of inflammatory mediators in keratinocytes is unclear.	Quercetin	23-32	tumor necrosis factor	Homo sapiens	118-151
23918355-7	2013	We found that quercetin-induced selective cell death is caused by mitochondrial accumulation of p53 and is sufficient to prevent teratoma formation after transplantation of hESC- or hiPSC-derived cells.	Quercetin	14-23	tumor protein p53	Homo sapiens	96-99
24133573-6	2013	Quercetin also increased the expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions.	Quercetin	0-9	beclin 1, autophagy related	Mus musculus	67-74
23432816-0	2013	Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa 1.1 channels.	Quercetin	0-9	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	80-87
23432816-2	2013	Thus, the aim of the present investigation was to address the hypothesis that quercetin-induced vasorelaxation is caused by a PKG-mediated stimulation of KCa 1.1 currents.	Quercetin	78-87	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	154-161
23432816-4	2013	RESULTS: Quercetin relaxed vessels and increased KCa 1.1 currents in a concentration-dependent manner: both effects were antagonized by the specific KCa 1.1 channel blocker iberiotoxin.	Quercetin	9-18	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	49-56
23432816-4	2013	RESULTS: Quercetin relaxed vessels and increased KCa 1.1 currents in a concentration-dependent manner: both effects were antagonized by the specific KCa 1.1 channel blocker iberiotoxin.	Quercetin	9-18	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	149-156
23432816-6	2013	Quercetin shifted by 34.3 mV the voltage dependence of KCa 1.1 channel activation towards more negative membrane potentials without affecting its slope.	Quercetin	0-9	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	55-62
23432816-7	2013	Under conditions of tight functional coupling between sarcoplasmic reticulum Ca(2+) release sites and KCa 1.1 channels, quercetin decreased both the frequency and the amplitude of KCa 1.1 transient currents in a ryanodine-like manner.	Quercetin	120-129	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	102-109
23432816-7	2013	Under conditions of tight functional coupling between sarcoplasmic reticulum Ca(2+) release sites and KCa 1.1 channels, quercetin decreased both the frequency and the amplitude of KCa 1.1 transient currents in a ryanodine-like manner.	Quercetin	120-129	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	180-187
23907460-0	2013	The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death.	Quercetin	60-69	Janus kinase 2	Homo sapiens	4-8
23907460-0	2013	The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death.	Quercetin	60-69	signal transducer and activator of transcription 3	Homo sapiens	9-14
23797318-5	2013	Treatment with quercetin prevented the increase in AChE activity when compared to Cd/ethanol group.	Quercetin	15-24	acetylcholinesterase	Rattus norvegicus	51-55
23797318-6	2013	Quercetin treatment prevented the cadmium-induced increase in NTPDase, 5-nucleotidase, and ADA activities in Cd/ethanol group when compared to saline/ethanol group.	Quercetin	0-9	adenosine deaminase	Rattus norvegicus	91-94
23711929-3	2013	Furthermore, the effect of quercetin-3-O-(2"-galloyl)-alpha-l-rhamnopyranoside (QGR), a new quercetin derivative, on TRAIL-induced apoptosis in keratinocytes has not been studied.	Quercetin	27-36	TNF superfamily member 10	Homo sapiens	117-122
23711929-7	2013	In contrast, quercetin induces cytotoxicity and had an additive effect on TRAIL-induced apoptosis-related protein activation and cell death.	Quercetin	13-22	TNF superfamily member 10	Homo sapiens	74-79
25788280-5	2013	Q-NPs effectively enhanced xanthine oxidase inhibitory and free radical scavenging effect of quercetin.	Quercetin	93-102	xanthine dehydrogenase	Mus musculus	27-43
25788280-6	2013	Furthermore, Q-NPs showed marked reduction (compared to quercetin alone) in production of nitric oxide and cytokine (interleukin-6 and tumor necrosis factor alpha) from lipopolysaccharide-activated macrophages.	Quercetin	56-65	interleukin 6	Mus musculus	117-130
25788280-6	2013	Furthermore, Q-NPs showed marked reduction (compared to quercetin alone) in production of nitric oxide and cytokine (interleukin-6 and tumor necrosis factor alpha) from lipopolysaccharide-activated macrophages.	Quercetin	56-65	tumor necrosis factor	Mus musculus	135-162
23475436-0	2013	Quercetin as a fluorescent probe for the ryanodine receptor activity in Jurkat cells.	Quercetin	0-9	ryanodine receptor 1	Homo sapiens	41-59
23490140-8	2013	On the other hand, increase in nitric oxide, malondialdehyde, luminol chemiluminescence levels, and myeloperoxidase and caspase 3 activities of tissues in the SCI group were significantly reversed by quercetin treatment.	Quercetin	200-209	myeloperoxidase	Rattus norvegicus	100-115
23490140-8	2013	On the other hand, increase in nitric oxide, malondialdehyde, luminol chemiluminescence levels, and myeloperoxidase and caspase 3 activities of tissues in the SCI group were significantly reversed by quercetin treatment.	Quercetin	200-209	caspase 3	Rattus norvegicus	120-129
24137346-5	2013	Quercetin liposome administration significantly reduced the MDA content and increased SOD and GSH-PX activities in the lung tissues, and reduced the total cell counts and inflammatory cell proportions in the BALF, plasma TNF-alpha and TGF-beta1 concentrations and the HP content in the lung tissues.	Quercetin	0-9	tumor necrosis factor	Mus musculus	221-230
24137346-5	2013	Quercetin liposome administration significantly reduced the MDA content and increased SOD and GSH-PX activities in the lung tissues, and reduced the total cell counts and inflammatory cell proportions in the BALF, plasma TNF-alpha and TGF-beta1 concentrations and the HP content in the lung tissues.	Quercetin	0-9	transforming growth factor, beta 1	Mus musculus	235-244
23475436-2	2013	Here, we present strong evidence that the ratio F380/F440 of the quercetin-specific cellular fluorescence emitted at 540 nm upon excitation at 380/440 nm reflects the open probability of an endoplasmic reticulum Ca(2+) release channel, the ryanodine receptor (RyR), in both intact and permeabilized Jurkat cells.	Quercetin	65-74	ryanodine receptor 1	Homo sapiens	240-258
23475436-2	2013	Here, we present strong evidence that the ratio F380/F440 of the quercetin-specific cellular fluorescence emitted at 540 nm upon excitation at 380/440 nm reflects the open probability of an endoplasmic reticulum Ca(2+) release channel, the ryanodine receptor (RyR), in both intact and permeabilized Jurkat cells.	Quercetin	65-74	ryanodine receptor 1	Homo sapiens	260-263
23475436-4	2013	The RyR specific inhibitor, ryanodine, the RyR type 3 and 1 but not type 2 specific inhibitor, dantrolene, as well as the non-specific RyR inhibitor, ruthenium red, depressed consistently the quercetin-induced Ca(2+) transient.	Quercetin	192-201	ryanodine receptor 1	Homo sapiens	4-7
23475436-4	2013	The RyR specific inhibitor, ryanodine, the RyR type 3 and 1 but not type 2 specific inhibitor, dantrolene, as well as the non-specific RyR inhibitor, ruthenium red, depressed consistently the quercetin-induced Ca(2+) transient.	Quercetin	192-201	ryanodine receptor 1	Homo sapiens	43-46
23475436-4	2013	The RyR specific inhibitor, ryanodine, the RyR type 3 and 1 but not type 2 specific inhibitor, dantrolene, as well as the non-specific RyR inhibitor, ruthenium red, depressed consistently the quercetin-induced Ca(2+) transient.	Quercetin	192-201	ryanodine receptor 1	Homo sapiens	43-46
23475436-8	2013	So, quercetin appears to be a semi-specific fluorescent probe for the activity of ryanodine receptors, which in our Jurkat (clone E6.1) cell preparations probably reports the type 3 RyR activity.	Quercetin	4-13	ryanodine receptor 1	Homo sapiens	182-185
23856194-0	2013	Quercetin suppresses inflammation by reducing ERK1/2 phosphorylation and NF kappa B activation in Leptin-induced Human Umbilical Vein Endothelial Cells (HUVECs).	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	46-52
23819596-9	2013	Quercetin treatment significantly reduced hind limb contracture, collagen accumulation and expression of TGF-beta in irradiated skin.	Quercetin	0-9	transforming growth factor, beta 1	Mus musculus	105-113
23819596-10	2013	Quercetin had no effect on the radioresponse of fibroblasts or murine tumors, but was capable of reducing the contractility of fibroblasts in response to TGF-beta, an effect that correlated with partial stabilization of phosphorylated cofilin.	Quercetin	0-9	transforming growth factor, beta 1	Mus musculus	154-162
23922702-10	2013	The neuroprotective effect of YC-1 was significantly attenuated by an Hsp70 inhibitor (quercetin, 50 microM) or in PC12 cells transfected with an Hsp70 small interfering RNA.	Quercetin	87-96	glutathione S-transferase alpha 1	Rattus norvegicus	30-34
23922702-10	2013	The neuroprotective effect of YC-1 was significantly attenuated by an Hsp70 inhibitor (quercetin, 50 microM) or in PC12 cells transfected with an Hsp70 small interfering RNA.	Quercetin	87-96	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	70-75
23894631-6	2013	Inhibition of HSP70 expression by quercetin caused a decrease in the amount of nuclear CP aggregates and a re-localization of a GFP-CP fusion protein from the nucleus to the cytoplasm.	Quercetin	34-43	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
23856194-0	2013	Quercetin suppresses inflammation by reducing ERK1/2 phosphorylation and NF kappa B activation in Leptin-induced Human Umbilical Vein Endothelial Cells (HUVECs).	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	73-83
23856194-0	2013	Quercetin suppresses inflammation by reducing ERK1/2 phosphorylation and NF kappa B activation in Leptin-induced Human Umbilical Vein Endothelial Cells (HUVECs).	Quercetin	0-9	leptin	Homo sapiens	98-104
23856194-2	2013	The objective of this study was to elucidate the role of quercetin in modulating leptin-induced inflammation as assessed by the levels of Ob-Ra expression, ERK1/2 phosphorylation, NF-kappa B activation and TNF-alpha secretion in umbilical vein endothelial cells (HUVECs) in vitro.	Quercetin	57-66	leptin	Homo sapiens	81-87
23856194-2	2013	The objective of this study was to elucidate the role of quercetin in modulating leptin-induced inflammation as assessed by the levels of Ob-Ra expression, ERK1/2 phosphorylation, NF-kappa B activation and TNF-alpha secretion in umbilical vein endothelial cells (HUVECs) in vitro.	Quercetin	57-66	tumor necrosis factor	Homo sapiens	206-215
23664836-1	2013	In this study we characterized (3)H-2-deoxy-d-glucose ((3)H -DG) uptake by the estrogen receptor (ER)-positive MCF7 and the ER-negative MDA-MB-231 human breast cancer cell lines and investigated the effect of quercetin (QUE) and epigallocatechin gallate (EGCG) upon (3)H-DG uptake, glucose metabolism and cell viability and proliferation.	Quercetin	209-218	estrogen receptor 1	Homo sapiens	79-96
24024175-0	2013	Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouse.	Quercetin	0-9	apolipoprotein E	Mus musculus	55-60
24024175-6	2013	Oral low dose quercetin (QCN; 0.1 micromol QCN/kg body weight for 6 weeks) significantly reduced total cholesterol and very low density lipoprotein in the plasma of Apo E(-/-) mice.	Quercetin	14-23	apolipoprotein E	Mus musculus	165-170
23664836-1	2013	In this study we characterized (3)H-2-deoxy-d-glucose ((3)H -DG) uptake by the estrogen receptor (ER)-positive MCF7 and the ER-negative MDA-MB-231 human breast cancer cell lines and investigated the effect of quercetin (QUE) and epigallocatechin gallate (EGCG) upon (3)H-DG uptake, glucose metabolism and cell viability and proliferation.	Quercetin	209-218	estrogen receptor 1	Homo sapiens	98-100
23664836-0	2013	Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism.	Quercetin	0-9	estrogen receptor 1	Homo sapiens	106-123
23664836-1	2013	In this study we characterized (3)H-2-deoxy-d-glucose ((3)H -DG) uptake by the estrogen receptor (ER)-positive MCF7 and the ER-negative MDA-MB-231 human breast cancer cell lines and investigated the effect of quercetin (QUE) and epigallocatechin gallate (EGCG) upon (3)H-DG uptake, glucose metabolism and cell viability and proliferation.	Quercetin	220-223	estrogen receptor 1	Homo sapiens	79-96
23664836-1	2013	In this study we characterized (3)H-2-deoxy-d-glucose ((3)H -DG) uptake by the estrogen receptor (ER)-positive MCF7 and the ER-negative MDA-MB-231 human breast cancer cell lines and investigated the effect of quercetin (QUE) and epigallocatechin gallate (EGCG) upon (3)H-DG uptake, glucose metabolism and cell viability and proliferation.	Quercetin	220-223	estrogen receptor 1	Homo sapiens	98-100
23874982-6	2013	The enhanced proliferation of CD8(+) T cells due to 4-1BB signaling was completely abolished by treatment with the TCF1/beta-catenin inhibitor quercetin.	Quercetin	143-152	CD8a molecule	Homo sapiens	30-33
23874982-6	2013	The enhanced proliferation of CD8(+) T cells due to 4-1BB signaling was completely abolished by treatment with the TCF1/beta-catenin inhibitor quercetin.	Quercetin	143-152	TNF receptor superfamily member 9	Homo sapiens	52-57
23688865-0	2013	Antioxidant effect of quercetin against acute spinal cord injury in rats and its correlation with the p38MAPK/iNOS signaling pathway.	Quercetin	22-31	mitogen activated protein kinase 14	Rattus norvegicus	102-109
23688865-0	2013	Antioxidant effect of quercetin against acute spinal cord injury in rats and its correlation with the p38MAPK/iNOS signaling pathway.	Quercetin	22-31	nitric oxide synthase 2	Rattus norvegicus	110-114
23688865-1	2013	AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI.	Quercetin	69-78	mitogen activated protein kinase 14	Rattus norvegicus	93-129
23688865-1	2013	AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI.	Quercetin	69-78	mitogen activated protein kinase 14	Rattus norvegicus	131-138
23688865-1	2013	AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI.	Quercetin	69-78	nitric oxide synthase 2	Rattus norvegicus	140-171
23688865-1	2013	AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI.	Quercetin	69-78	nitric oxide synthase 2	Rattus norvegicus	173-177
23688865-1	2013	AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI.	Quercetin	80-83	mitogen activated protein kinase 14	Rattus norvegicus	93-129
23688865-1	2013	AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI.	Quercetin	80-83	mitogen activated protein kinase 14	Rattus norvegicus	131-138
23874982-6	2013	The enhanced proliferation of CD8(+) T cells due to 4-1BB signaling was completely abolished by treatment with the TCF1/beta-catenin inhibitor quercetin.	Quercetin	143-152	transcription factor 7	Homo sapiens	115-119
23688865-1	2013	AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI.	Quercetin	80-83	nitric oxide synthase 2	Rattus norvegicus	140-171
23688865-1	2013	AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI.	Quercetin	80-83	nitric oxide synthase 2	Rattus norvegicus	173-177
23688865-6	2013	Que significantly inhibited increases in phosphorylated-p38MAPK (p-p38MAPK) and iNOS expression and reduced the rate of iNOS-positive cells in rats with SCI, similar to the effects of SB203580.	Quercetin	0-3	mitogen activated protein kinase 14	Rattus norvegicus	56-63
23874982-6	2013	The enhanced proliferation of CD8(+) T cells due to 4-1BB signaling was completely abolished by treatment with the TCF1/beta-catenin inhibitor quercetin.	Quercetin	143-152	catenin beta 1	Homo sapiens	120-132
23688865-6	2013	Que significantly inhibited increases in phosphorylated-p38MAPK (p-p38MAPK) and iNOS expression and reduced the rate of iNOS-positive cells in rats with SCI, similar to the effects of SB203580.	Quercetin	0-3	mitogen activated protein kinase 14	Rattus norvegicus	67-74
23688865-6	2013	Que significantly inhibited increases in phosphorylated-p38MAPK (p-p38MAPK) and iNOS expression and reduced the rate of iNOS-positive cells in rats with SCI, similar to the effects of SB203580.	Quercetin	0-3	nitric oxide synthase 2	Rattus norvegicus	80-84
23647015-0	2013	Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats.	Quercetin	0-9	thioredoxin interacting protein	Rattus norvegicus	39-70
23688865-6	2013	Que significantly inhibited increases in phosphorylated-p38MAPK (p-p38MAPK) and iNOS expression and reduced the rate of iNOS-positive cells in rats with SCI, similar to the effects of SB203580.	Quercetin	0-3	nitric oxide synthase 2	Rattus norvegicus	120-124
23647015-2	2013	In this study we investigated whether TXNIP is involved in type 1 diabetes-associated NAFLD and whether antioxidants, quercetin and allopurinol, alleviate NAFLD by targeting TXNIP.	Quercetin	118-127	thioredoxin interacting protein	Rattus norvegicus	174-179
23647015-9	2013	KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver.	Quercetin	13-22	thioredoxin interacting protein	Rattus norvegicus	67-72
23673431-6	2013	Compared to quercetin and 2-ME alone, combining quercetin with 2-ME at appropriate concentrations i) showed synergistic antiproliferative and proapoptotic activities; ii) increased G2/M phase population of cells; iii) decreased the ratio of Bcl-2/Bax significantly.	Quercetin	48-57	BCL2 apoptosis regulator	Homo sapiens	241-246
23647015-9	2013	KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver.	Quercetin	13-22	NLR family, pyrin domain containing 3	Rattus norvegicus	103-108
23647015-9	2013	KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver.	Quercetin	13-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	142-151
23647015-9	2013	KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver.	Quercetin	13-22	sterol regulatory element binding transcription factor 1	Rattus norvegicus	173-217
23647015-9	2013	KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver.	Quercetin	13-22	sterol regulatory element binding transcription factor 1	Rattus norvegicus	219-227
23647015-9	2013	KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver.	Quercetin	13-22	sterol regulatory element binding transcription factor 2	Rattus norvegicus	230-237
23647015-9	2013	KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver.	Quercetin	13-22	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	263-285
23647015-9	2013	KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver.	Quercetin	13-22	interleukin 1 beta	Rattus norvegicus	319-327
23647015-11	2013	CONCLUSIONS AND IMPLICATIONS: Inhibition of hepatic TXNIP by quercetin and allopurinol contributes to the reduction in liver inflammation and lipid accumulation under hyperglycaemic conditions.	Quercetin	61-70	thioredoxin interacting protein	Rattus norvegicus	52-57
23647015-12	2013	The targeting of hepatic TXNIP by quercetin and allopurinol may have therapeutic implications for prevention of type 1 diabetes-associated NAFLD.	Quercetin	34-43	thioredoxin interacting protein	Rattus norvegicus	25-30
23560676-0	2013	On the repair of oxidative damage to apoferritin: a model study with the flavonoids quercetin and rutin in aerated and deaerated solutions.	Quercetin	84-93	ferritin heavy chain	Equus caballus	37-48
24049596-9	2013	Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P &lt; 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	75-102
24049596-9	2013	Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P &lt; 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	104-113
24049596-9	2013	Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P &lt; 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups.	Quercetin	0-9	interleukin 6	Homo sapiens	119-132
24049596-9	2013	Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P &lt; 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups.	Quercetin	0-9	interleukin 6	Homo sapiens	134-138
24049596-9	2013	Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P &lt; 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups.	Quercetin	0-9	interleukin 6	Homo sapiens	229-233
24049596-9	2013	Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P &lt; 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	235-244
24049596-9	2013	Quercetin supplementation significantly reduced the serum concentration of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) (P = 0.01 and P &lt; 0.0001, respectively); however, the mean changes in serum levels of IL-6, TNF-alpha, and high-sensitivity C-reactive protein were not significant between the groups.	Quercetin	0-9	C-reactive protein	Homo sapiens	267-285
23559539-8	2013	Inhibition of AMPK activity decreased phase II enzyme activities that were upregulated by treatment with ACA plus sodium butyrate or other phytochemicals, including kaempferol, quercetin, and epigallocatechin-3-gallate.	Quercetin	177-186	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18
23673431-6	2013	Compared to quercetin and 2-ME alone, combining quercetin with 2-ME at appropriate concentrations i) showed synergistic antiproliferative and proapoptotic activities; ii) increased G2/M phase population of cells; iii) decreased the ratio of Bcl-2/Bax significantly.	Quercetin	48-57	BCL2 associated X, apoptosis regulator	Homo sapiens	247-250
23668856-4	2013	The protective effect of quercetin was associated with its capacity to inhibit the redistribution of ZO-1 protein induced in the tight junction by indomethacin or rotenone, a mitochondrial complex-I inhibitor, and to prevent the decrease of ZO-1 and occludin expression induced by indomethacin.	Quercetin	25-34	tight junction protein 1	Homo sapiens	101-105
23583009-8	2013	CO scavenging blocked the suppression of quercetin only on CYP2E1 activity.	Quercetin	41-50	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	59-65
23583009-10	2013	Thus, CYP2E1-mediated ethanol hepatotoxicity was alleviated by quercetin through HO-1 induction.	Quercetin	63-72	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	6-12
23583009-10	2013	Thus, CYP2E1-mediated ethanol hepatotoxicity was alleviated by quercetin through HO-1 induction.	Quercetin	63-72	heme oxygenase 1	Homo sapiens	81-85
23583009-0	2013	Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO.	Quercetin	0-9	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	21-27
23583009-2	2013	However, the precise mechanism by which quercetin counteracts CYP2E1-mediated ethanol hepatotoxicity through HO-1 system is still remained unclear.	Quercetin	40-49	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	62-68
23583009-2	2013	However, the precise mechanism by which quercetin counteracts CYP2E1-mediated ethanol hepatotoxicity through HO-1 system is still remained unclear.	Quercetin	40-49	heme oxygenase 1	Homo sapiens	109-113
23583009-5	2013	Our data showed that chronic ethanol over-activated CYP2E1 but suppressed HO-1 with concurrent hepatic oxidative damage, which was partially normalized by quercetin (100mg/kg.bw.).	Quercetin	155-164	heme oxygenase 1	Homo sapiens	74-78
23583009-6	2013	Quercetin (100 muM) induced HO-1 and depleted heme pool when incubated to human hepatocytes.	Quercetin	0-9	heme oxygenase 1	Homo sapiens	28-32
23583009-7	2013	Ethanol-stimulated (100mM) CYP2E1 upregulation was suppressed by quercetin but further enhanced by HO-1 inhibition with resultant heme accumulation.	Quercetin	65-74	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	27-33
23668856-4	2013	The protective effect of quercetin was associated with its capacity to inhibit the redistribution of ZO-1 protein induced in the tight junction by indomethacin or rotenone, a mitochondrial complex-I inhibitor, and to prevent the decrease of ZO-1 and occludin expression induced by indomethacin.	Quercetin	25-34	tight junction protein 1	Homo sapiens	241-245
23668856-4	2013	The protective effect of quercetin was associated with its capacity to inhibit the redistribution of ZO-1 protein induced in the tight junction by indomethacin or rotenone, a mitochondrial complex-I inhibitor, and to prevent the decrease of ZO-1 and occludin expression induced by indomethacin.	Quercetin	25-34	occludin	Homo sapiens	250-258
23549747-5	2013	For the synthesis of quercetin 3-O-glucoside-7-O-rhamnoside, AtUGT78D2, which transfers glucose from UDP-glucose to the 3-hydroxyl group of quercetin, and AtUGT89C1, which transfers rhamnose from UDP-rhamnose to the 7-hydroxyl group of quercetin 3-O-glucoside, were transformed into E. coli.	Quercetin	21-30	UDP-glucosyl transferase 78D2	Arabidopsis thaliana	61-70
23564507-0	2013	Simultaneous inactivation of GSK-3beta suppresses quercetin-induced apoptosis by inhibiting the JNK pathway.	Quercetin	50-59	glycogen synthase kinase 3 beta	Homo sapiens	29-38
23564507-0	2013	Simultaneous inactivation of GSK-3beta suppresses quercetin-induced apoptosis by inhibiting the JNK pathway.	Quercetin	50-59	mitogen-activated protein kinase 8	Homo sapiens	96-99
23564507-8	2013	Quercetin activated JNK and increased the expression levels of c-Jun and p53-dependent Bax.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	20-23
23564507-8	2013	Quercetin activated JNK and increased the expression levels of c-Jun and p53-dependent Bax.	Quercetin	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
23564507-8	2013	Quercetin activated JNK and increased the expression levels of c-Jun and p53-dependent Bax.	Quercetin	0-9	tumor protein p53	Homo sapiens	73-76
23564507-8	2013	Quercetin activated JNK and increased the expression levels of c-Jun and p53-dependent Bax.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
23564507-9	2013	Blockade of JNK activation by overexpression of dominant negative JNK1 suppressed apoptosis by quercetin via inhibition of caspase-3 activation and reduction of p53 and Bax expression.	Quercetin	95-104	mitogen-activated protein kinase 8	Homo sapiens	12-15
23564507-9	2013	Blockade of JNK activation by overexpression of dominant negative JNK1 suppressed apoptosis by quercetin via inhibition of caspase-3 activation and reduction of p53 and Bax expression.	Quercetin	95-104	mitogen-activated protein kinase 8	Homo sapiens	66-70
23564507-9	2013	Blockade of JNK activation by overexpression of dominant negative JNK1 suppressed apoptosis by quercetin via inhibition of caspase-3 activation and reduction of p53 and Bax expression.	Quercetin	95-104	caspase 3	Homo sapiens	123-132
23564507-9	2013	Blockade of JNK activation by overexpression of dominant negative JNK1 suppressed apoptosis by quercetin via inhibition of caspase-3 activation and reduction of p53 and Bax expression.	Quercetin	95-104	tumor protein p53	Homo sapiens	161-164
23564507-9	2013	Blockade of JNK activation by overexpression of dominant negative JNK1 suppressed apoptosis by quercetin via inhibition of caspase-3 activation and reduction of p53 and Bax expression.	Quercetin	95-104	BCL2 associated X, apoptosis regulator	Homo sapiens	169-172
23564507-10	2013	Simultaneously, quercetin inactivated glycogen synthase kinase (GSK)-3beta, which is phosphatidylinositol 3-kinase/Akt dependent.	Quercetin	16-25	AKT serine/threonine kinase 1	Homo sapiens	115-118
23564507-11	2013	Overexpression of a constitutively active GSK-3beta mutant enhanced quercetin-induced JNK activation.	Quercetin	68-77	glycogen synthase kinase 3 beta	Homo sapiens	42-51
23564507-11	2013	Overexpression of a constitutively active GSK-3beta mutant enhanced quercetin-induced JNK activation.	Quercetin	68-77	mitogen-activated protein kinase 8	Homo sapiens	86-89
23564507-12	2013	In contrast, overexpression of enzymatically inert GSK-3beta inhibited JNK activation, resulting in a suppression of apoptosis by quercetin.	Quercetin	130-139	glycogen synthase kinase 3 beta	Homo sapiens	51-60
23564507-12	2013	In contrast, overexpression of enzymatically inert GSK-3beta inhibited JNK activation, resulting in a suppression of apoptosis by quercetin.	Quercetin	130-139	mitogen-activated protein kinase 8	Homo sapiens	71-74
23564507-13	2013	Taken together, the JNK-p53 pathway is involved in quercetin-induced apoptosis, and simultaneous inactivation of GSK-3beta can attenuate apoptosis in normal bronchial epithelial cells.	Quercetin	51-60	mitogen-activated protein kinase 8	Homo sapiens	20-23
23564507-13	2013	Taken together, the JNK-p53 pathway is involved in quercetin-induced apoptosis, and simultaneous inactivation of GSK-3beta can attenuate apoptosis in normal bronchial epithelial cells.	Quercetin	51-60	tumor protein p53	Homo sapiens	24-27
23549747-7	2013	For the synthesis of quercetin 3,7-O-bisrhamnoside, AtUGT78D1, which transfers rhamnose to the 3-hydroxy group of quercetin, and AtUGT89C1 were used.	Quercetin	21-30	UDP-glucosyl transferase 78D1	Arabidopsis thaliana	52-61
23537890-0	2013	The involvement of heme oxygenase 1 but not nitric oxide synthase 2 in a hepatoprotective action of quercetin in lipopolysaccharide-induced hepatotoxicity of D-galactosamine sensitized rats.	Quercetin	100-109	heme oxygenase 1	Rattus norvegicus	19-35
22817837-10	2013	Quercetin is an inhibitor of CYP3A4 and P-gp.	Quercetin	0-9	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	40-44
23537890-1	2013	The objective of this study was to evaluate potential hepatoprotective capabilities of quercetin in relation to its modulation of the HO-1 and NOS-2 activities in an experimental model of fulminant liver failure.	Quercetin	87-96	heme oxygenase 1	Rattus norvegicus	134-138
23537890-1	2013	The objective of this study was to evaluate potential hepatoprotective capabilities of quercetin in relation to its modulation of the HO-1 and NOS-2 activities in an experimental model of fulminant liver failure.	Quercetin	87-96	nitric oxide synthase 2	Rattus norvegicus	143-148
23537890-4	2013	The effects of quercetin (50 mg/kg, i.p) on D-GalN toxicity was evaluated by standard biochemical, RT-PCR and Western blot methods.	Quercetin	15-24	galanin and GMAP prepropeptide	Rattus norvegicus	46-50
23537890-7	2013	Additionally, quercetin treatment in D-GalN/LPS treated rats significantly increased HO-1 mRNA and its protein expressions.	Quercetin	14-23	galanin and GMAP prepropeptide	Rattus norvegicus	39-43
23537890-7	2013	Additionally, quercetin treatment in D-GalN/LPS treated rats significantly increased HO-1 mRNA and its protein expressions.	Quercetin	14-23	heme oxygenase 1	Rattus norvegicus	85-89
23537890-10	2013	It can be concluded that the quercetin"s induction of HO-1 and its byproducts, without concomitant NOS-2 activity reduction, is among mechanisms contributing to the hepatoprotective effect in D-GalN/LPS hepatotoxicity.	Quercetin	29-38	heme oxygenase 1	Rattus norvegicus	54-58
23537890-10	2013	It can be concluded that the quercetin"s induction of HO-1 and its byproducts, without concomitant NOS-2 activity reduction, is among mechanisms contributing to the hepatoprotective effect in D-GalN/LPS hepatotoxicity.	Quercetin	29-38	nitric oxide synthase 2	Rattus norvegicus	99-104
23537890-10	2013	It can be concluded that the quercetin"s induction of HO-1 and its byproducts, without concomitant NOS-2 activity reduction, is among mechanisms contributing to the hepatoprotective effect in D-GalN/LPS hepatotoxicity.	Quercetin	29-38	galanin and GMAP prepropeptide	Rattus norvegicus	194-198
23504962-0	2013	Quercetin and quercetin-3-O-glucuronide are equally effective in ameliorating endothelial insulin resistance through inhibition of reactive oxygen species-associated inflammation.	Quercetin	0-9	insulin	Homo sapiens	90-97
23590821-4	2013	Our results suggest that ES and EM that are rich in p-coumaric acid, rutin, morin or quercetin, may have strong immunomodulatory effects on splenocytes, via decreasing Th1/Th2 and pro-/anti-inflammatory cytokine secretion ratios.	Quercetin	85-94	negative elongation factor complex member C/D, Th1l	Mus musculus	168-171
23590821-4	2013	Our results suggest that ES and EM that are rich in p-coumaric acid, rutin, morin or quercetin, may have strong immunomodulatory effects on splenocytes, via decreasing Th1/Th2 and pro-/anti-inflammatory cytokine secretion ratios.	Quercetin	85-94	heart and neural crest derivatives expressed 2	Mus musculus	172-175
23504962-3	2013	This study aims to parallelly investigate whether quercetin and quercetin-3-O-glucuronide exert protection against palmitate (PA)-induced inflammation and insulin resistance in the endothelium.	Quercetin	50-59	insulin	Homo sapiens	155-162
23504962-7	2013	Also, quercetin and quercetin-3-O-glucuronide inhibited ROS-associated inflammation by inhibition of interleukin-6 and tumor necrosis factor-alpha production with suppression of IKKbeta/NF-kappaB phosphorylation.	Quercetin	6-15	interleukin 6	Homo sapiens	101-146
23504962-7	2013	Also, quercetin and quercetin-3-O-glucuronide inhibited ROS-associated inflammation by inhibition of interleukin-6 and tumor necrosis factor-alpha production with suppression of IKKbeta/NF-kappaB phosphorylation.	Quercetin	6-15	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	178-185
23504962-9	2013	Quercetin and quercetin-3-O-glucuronide facilitated PI3K signaling by positive regulation of serine/tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and restoration of downstream Akt/eNOS activation, leading to an increased insulin-mediated NO level.	Quercetin	0-9	insulin receptor substrate 1	Homo sapiens	128-156
23504962-9	2013	Quercetin and quercetin-3-O-glucuronide facilitated PI3K signaling by positive regulation of serine/tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and restoration of downstream Akt/eNOS activation, leading to an increased insulin-mediated NO level.	Quercetin	0-9	insulin receptor substrate 1	Homo sapiens	158-163
23504962-9	2013	Quercetin and quercetin-3-O-glucuronide facilitated PI3K signaling by positive regulation of serine/tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and restoration of downstream Akt/eNOS activation, leading to an increased insulin-mediated NO level.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	195-198
23504962-9	2013	Quercetin and quercetin-3-O-glucuronide facilitated PI3K signaling by positive regulation of serine/tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and restoration of downstream Akt/eNOS activation, leading to an increased insulin-mediated NO level.	Quercetin	0-9	insulin	Homo sapiens	128-135
23504962-10	2013	CONCLUSION: The above-mentioned evidence indicates that quercetin and quercetin-3-O-glucuronide are equally effective in inhibiting ROS-associated inflammation and ameliorating insulin resistant endothelial dysfunction by beneficial regulation of IRS-1 function.	Quercetin	56-65	insulin	Homo sapiens	177-184
23504962-10	2013	CONCLUSION: The above-mentioned evidence indicates that quercetin and quercetin-3-O-glucuronide are equally effective in inhibiting ROS-associated inflammation and ameliorating insulin resistant endothelial dysfunction by beneficial regulation of IRS-1 function.	Quercetin	56-65	insulin receptor substrate 1	Homo sapiens	247-252
23571140-7	2013	The intravenous administration of quercetin significantly attenuated the increase of APTT, PT, ALT, BUN, and TNF-alpha, and the decrease of plasma FIB level and activity of Protein C and ATIII.	Quercetin	34-43	tumor necrosis factor	Oryctolagus cuniculus	109-118
23656499-7	2013	Quercetin noticeably elevated osteocalcin as a bone formation marker, while alendronate did not show such an effect.	Quercetin	0-9	bone gamma-carboxyglutamate protein	Rattus norvegicus	30-41
23376017-3	2013	We have previously reported on the identification of quercetin and vitexin as SIRT6 inhibitors, using SIRT6-coated magnetic beads.	Quercetin	53-62	sirtuin 6	Homo sapiens	78-83
23376017-3	2013	We have previously reported on the identification of quercetin and vitexin as SIRT6 inhibitors, using SIRT6-coated magnetic beads.	Quercetin	53-62	sirtuin 6	Homo sapiens	102-107
23376017-4	2013	In this study, we have immobilized SIRT6 onto the surface of an open tubular capillary and characterized the quercetin binding site using frontal displacement chromatography.	Quercetin	109-118	sirtuin 6	Homo sapiens	35-40
23645742-0	2013	Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-kappaB and matrix metalloproteinase-2/-9 signaling pathways.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	95-104
23645742-0	2013	Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-kappaB and matrix metalloproteinase-2/-9 signaling pathways.	Quercetin	0-9	matrix metallopeptidase 2	Homo sapiens	109-135
23645742-4	2013	Results indicated that quercetin inhibited the expression and activity of matrix metalloproteinase (MMP)-2 and MMP-9, as measured by western blotting and gelatin zymography.	Quercetin	23-32	matrix metallopeptidase 2	Homo sapiens	74-106
23645742-4	2013	Results indicated that quercetin inhibited the expression and activity of matrix metalloproteinase (MMP)-2 and MMP-9, as measured by western blotting and gelatin zymography.	Quercetin	23-32	matrix metallopeptidase 9	Homo sapiens	111-116
23645742-6	2013	Confocal laser microscopy also showed that quercetin promoted the expressions of RhoA and Rho-associated, coiled-coil containing protein kinase-1 (ROCK1), but inhibited the expression of NF-kappaB p65 in SAS cells.	Quercetin	43-52	ras homolog family member A	Homo sapiens	81-85
23645742-6	2013	Confocal laser microscopy also showed that quercetin promoted the expressions of RhoA and Rho-associated, coiled-coil containing protein kinase-1 (ROCK1), but inhibited the expression of NF-kappaB p65 in SAS cells.	Quercetin	43-52	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	90-145
23645742-6	2013	Confocal laser microscopy also showed that quercetin promoted the expressions of RhoA and Rho-associated, coiled-coil containing protein kinase-1 (ROCK1), but inhibited the expression of NF-kappaB p65 in SAS cells.	Quercetin	43-52	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	147-152
23645742-6	2013	Confocal laser microscopy also showed that quercetin promoted the expressions of RhoA and Rho-associated, coiled-coil containing protein kinase-1 (ROCK1), but inhibited the expression of NF-kappaB p65 in SAS cells.	Quercetin	43-52	nuclear factor kappa B subunit 1	Homo sapiens	187-196
23645742-6	2013	Confocal laser microscopy also showed that quercetin promoted the expressions of RhoA and Rho-associated, coiled-coil containing protein kinase-1 (ROCK1), but inhibited the expression of NF-kappaB p65 in SAS cells.	Quercetin	43-52	RELA proto-oncogene, NF-kB subunit	Homo sapiens	197-200
23645742-7	2013	It is concluded from these data that inhibition of migration and invasion of SAS cells by quercetin is associated with the down-regulation of PKC and RhoA by blocking MAPK and PI3K/AKT signaling pathways and NF-kappaB and uPA, resulting in inhibition of MMP-2 and MMP-9 signaling.	Quercetin	90-99	ras homolog family member A	Homo sapiens	150-154
23645742-7	2013	It is concluded from these data that inhibition of migration and invasion of SAS cells by quercetin is associated with the down-regulation of PKC and RhoA by blocking MAPK and PI3K/AKT signaling pathways and NF-kappaB and uPA, resulting in inhibition of MMP-2 and MMP-9 signaling.	Quercetin	90-99	mitogen activated protein kinase 3	Rattus norvegicus	167-171
23645742-7	2013	It is concluded from these data that inhibition of migration and invasion of SAS cells by quercetin is associated with the down-regulation of PKC and RhoA by blocking MAPK and PI3K/AKT signaling pathways and NF-kappaB and uPA, resulting in inhibition of MMP-2 and MMP-9 signaling.	Quercetin	90-99	nuclear factor kappa B subunit 1	Homo sapiens	208-217
23645742-7	2013	It is concluded from these data that inhibition of migration and invasion of SAS cells by quercetin is associated with the down-regulation of PKC and RhoA by blocking MAPK and PI3K/AKT signaling pathways and NF-kappaB and uPA, resulting in inhibition of MMP-2 and MMP-9 signaling.	Quercetin	90-99	plasminogen activator, urokinase	Homo sapiens	222-225
23645742-7	2013	It is concluded from these data that inhibition of migration and invasion of SAS cells by quercetin is associated with the down-regulation of PKC and RhoA by blocking MAPK and PI3K/AKT signaling pathways and NF-kappaB and uPA, resulting in inhibition of MMP-2 and MMP-9 signaling.	Quercetin	90-99	matrix metallopeptidase 2	Homo sapiens	254-259
23645742-7	2013	It is concluded from these data that inhibition of migration and invasion of SAS cells by quercetin is associated with the down-regulation of PKC and RhoA by blocking MAPK and PI3K/AKT signaling pathways and NF-kappaB and uPA, resulting in inhibition of MMP-2 and MMP-9 signaling.	Quercetin	90-99	matrix metallopeptidase 9	Homo sapiens	264-269
23480575-3	2013	Quantum mechanical calculations using density function theory (DFT) indicate a modest decrease in bond dissociation enthalpy, BDE, for (weakest) hydrogen-oxygen phenolic bond in daidzein from 368.4 kJ   mol(- 1) to 367.7 kJ   mol(- 1) compared to a significant increase in quercetin from 329.5 kJ   mol(- 1) to 356.6 kJ   mol(- 1) upon derivatization.	Quercetin	273-282	homeobox D13	Homo sapiens	126-129
23265512-7	2013	The three in vivo quercetin metabolites; quercetin-3"-sulfate, quercetin-3-glucuronic acid and isorhamnetin-3-glucuronic acid were effective at physiological concentrations and therefore, QAE can be effective in LDL-C oxidation inhibition under physiological conditions.	Quercetin	18-27	component of oligomeric golgi complex 2	Homo sapiens	212-217
22918785-7	2013	Quercetin supplementation to Al-treated animals also reduced oxidative stress, decreased ROS production, increased MnSOD activity and glutathione levels with decreased lipid peroxidation and protein oxidation.	Quercetin	0-9	superoxide dismutase 2	Rattus norvegicus	115-120
23432965-0	2013	Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest.	Quercetin	16-25	caspase 3	Homo sapiens	111-120
23432965-9	2013	Treatment of CLL cells with resveratrol and quercetin caused dose dependent inhibition of cell proliferation and increased apoptotic cell population through induction of caspase-3 activity.	Quercetin	44-53	caspase 3	Homo sapiens	170-179
22740083-3	2013	It has been reported that quercetin can suppress cancer by inhibiting the intratumoral expression of Hsp70.	Quercetin	26-35	heat shock protein 1B	Mus musculus	101-106
22740083-7	2013	The results showed that quercetin liposome inhibited the upregulation of Hsp70 and enhanced apoptosis induced by hyperthermia and thermochemotherapy.	Quercetin	24-33	heat shock protein 1B	Mus musculus	73-78
23271130-2	2013	Bm-UGT10286 (UGT86) is the sole provider of UGT activity against the 5-O position of quercetin and directly influences the formation of green pigment in the Bombyx cocoon.	Quercetin	85-94	UDP-glucosyltransferase	Bombyx mori	0-11
23271130-2	2013	Bm-UGT10286 (UGT86) is the sole provider of UGT activity against the 5-O position of quercetin and directly influences the formation of green pigment in the Bombyx cocoon.	Quercetin	85-94	UDP-glucosyltransferase	Bombyx mori	13-18
23271130-2	2013	Bm-UGT10286 (UGT86) is the sole provider of UGT activity against the 5-O position of quercetin and directly influences the formation of green pigment in the Bombyx cocoon.	Quercetin	85-94	uridine diphosphate glucosyltransferase	Bombyx mori	3-6
23271130-6	2013	In vitro, the fusion protein of UGT86 showed quercetin metabolic activity.	Quercetin	45-54	UDP-glucosyltransferase	Bombyx mori	32-37
23649461-0	2013	Relative antioxidant activities of quercetin and its structurally related substances and their effects on NF-kappaB/CRE/AP-1 signaling in murine macrophages.	Quercetin	35-44	jun proto-oncogene	Mus musculus	120-124
23396185-9	2013	However, the pre-treatment of Quercetin in a dose-response manner prevented these changes and restored the expansion of neurospheres preferably by neutralizing the oxidative conditions and thereby reducing peroxynitrite formation, protein nitration and PK-M2 depletion.	Quercetin	30-39	pyruvate kinase M1/2	Rattus norvegicus	253-258
23271130-12	2013	The conclusion is that the reaction of Ugt86 on the silkworm cocoon pigment quercetin is not the result of active mimetic ecogenesis, but derives from the detoxification of UGTs.	Quercetin	76-85	UDP-glucosyltransferase	Bombyx mori	39-44
23649461-5	2013	Regarding mechanisms, the quercetincontaining flavonoids QGR and QGG differentially targeted compared with quercetin in the NF-kappaB signaling pathway that inhibited the DNA binding activity of the NF-kappaB complex without affecting the degradation and phosphorylation of IkappaBalpha and NF-kappaB phosphorylation.	Quercetin	26-35	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	274-286
23434495-9	2013	Both quercetin (CYP2C8 inhibitor) and ketoconazole (CYP3A4 inhibitor) showed 60-100% inhibition of M1-M4 and M6 formations in HLMs, while M5 formation was mainly inhibited by alpha-naphthoflavone (CYP1A2 inhibitor, 70-80%) and quercetin (90%).	Quercetin	5-14	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	16-22
23357119-6	2013	We observed dose-dependent attenuation of the rotenone-induced loss in striatal dopamine, and nigral oxidized and reduced glutathione, as well as the increases in endogenous antioxidant enzymes (catalase and superoxide dismutase) activities supporting the notion that quercetin-effect is mediated via its powerful hydroxyl radicals-scavenging and antioxidant actions.	Quercetin	268-277	catalase	Rattus norvegicus	195-228
22118955-0	2013	Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms.	Quercetin	10-19	apolipoprotein E	Homo sapiens	117-121
22118955-8	2013	Quercetin also moderately increased levels of TNFalpha (P = 0.024).	Quercetin	0-9	tumor necrosis factor	Homo sapiens	46-54
23620721-10	2013	However, it was observed that oral treatment of nanoencapsulated quercetin (2.7 mg/kg b wt) resulted in downregulation of iNOS and caspase-3 activities and improved neuronal count in the hippocampal subfields even 3 days after reperfusion.	Quercetin	65-74	nitric oxide synthase 2	Rattus norvegicus	122-126
23620721-10	2013	However, it was observed that oral treatment of nanoencapsulated quercetin (2.7 mg/kg b wt) resulted in downregulation of iNOS and caspase-3 activities and improved neuronal count in the hippocampal subfields even 3 days after reperfusion.	Quercetin	65-74	caspase 3	Rattus norvegicus	131-140
23434495-9	2013	Both quercetin (CYP2C8 inhibitor) and ketoconazole (CYP3A4 inhibitor) showed 60-100% inhibition of M1-M4 and M6 formations in HLMs, while M5 formation was mainly inhibited by alpha-naphthoflavone (CYP1A2 inhibitor, 70-80%) and quercetin (90%).	Quercetin	5-14	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	197-203
23434495-9	2013	Both quercetin (CYP2C8 inhibitor) and ketoconazole (CYP3A4 inhibitor) showed 60-100% inhibition of M1-M4 and M6 formations in HLMs, while M5 formation was mainly inhibited by alpha-naphthoflavone (CYP1A2 inhibitor, 70-80%) and quercetin (90%).	Quercetin	227-236	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	16-22
23434495-9	2013	Both quercetin (CYP2C8 inhibitor) and ketoconazole (CYP3A4 inhibitor) showed 60-100% inhibition of M1-M4 and M6 formations in HLMs, while M5 formation was mainly inhibited by alpha-naphthoflavone (CYP1A2 inhibitor, 70-80%) and quercetin (90%).	Quercetin	227-236	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	52-58
23353698-0	2013	ABT-737 resistance in B-cells isolated from chronic lymphocytic leukemia patients and leukemia cell lines is overcome by the pleiotropic kinase inhibitor quercetin through Mcl-1 down-regulation.	Quercetin	154-163	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	172-177
23454558-12	2013	Pretreatment with quercetin, which was showed to inhibit HSP-70 expression, abolished glutamine"s renal-protective effects.	Quercetin	18-27	heat shock protein 1B	Mus musculus	57-63
23454558-13	2013	Quercetin also abrogated glutamine"s beneficial effects on renal TNF-alpha, chemokines, and neutrophil infiltration.	Quercetin	0-9	tumor necrosis factor	Mus musculus	65-74
23295967-0	2013	Oxidized quercetin inhibits alpha-synuclein fibrillization.	Quercetin	9-18	synuclein alpha	Homo sapiens	28-43
23353698-4	2013	Previous studies demonstrated that quercetin, a flavonoid naturally present in food and beverages, was able to sensitize B-cells isolated from CLL patients to apoptosis when associated with death ligands or fludarabine, through a mechanism involving Mcl-1 down-regulation.	Quercetin	35-44	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	250-255
23353698-8	2013	In this cell line, quercetin down-regulated Mcl-1 through the inhibition of PI3K/Akt signaling pathway, leading to Mcl-1 instability.	Quercetin	19-28	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	44-49
23353698-8	2013	In this cell line, quercetin down-regulated Mcl-1 through the inhibition of PI3K/Akt signaling pathway, leading to Mcl-1 instability.	Quercetin	19-28	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	115-120
23295412-3	2013	Maternal intake of quercetin increased the expression of Nrf2 and Sod2 in fetal liver at gestational day 14.5.	Quercetin	19-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
23241588-6	2013	Finally, the inhibition of the proteasome by a combination of quercetin plus tannic acid in Hep-2 cells resulted in the induction of S5a at low dose, accumulation of ubiquitin, and the cleavage of pro-caspase-3, followed by the induction of apoptotic cell death.	Quercetin	62-71	caspase 3	Homo sapiens	197-210
23510470-5	2013	RESULTS: Quercetin intercalated with calf thymus cell DNA and HeLa cell DNA and inhibition of anti-apoptotic AKT and Bcl-2 expression were observed.	Quercetin	9-18	AKT serine/threonine kinase 1	Homo sapiens	109-112
23510470-5	2013	RESULTS: Quercetin intercalated with calf thymus cell DNA and HeLa cell DNA and inhibition of anti-apoptotic AKT and Bcl-2 expression were observed.	Quercetin	9-18	BCL2 apoptosis regulator	Homo sapiens	117-122
23172919-8	2013	In addition, we characterize two CD38 inhibitors: quercetin and apigenin.	Quercetin	50-59	CD38 antigen	Mus musculus	33-37
23422925-0	2013	Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects.	Quercetin	10-19	ATP binding cassette subfamily B member 1	Homo sapiens	23-37
23422925-1	2013	OBJECTIVES: The aim of this study was to investigate the effect of quercetin on P-glycoprotein (P-gp) transport ability in vivo.	Quercetin	67-76	ATP binding cassette subfamily B member 1	Homo sapiens	80-94
23422925-1	2013	OBJECTIVES: The aim of this study was to investigate the effect of quercetin on P-glycoprotein (P-gp) transport ability in vivo.	Quercetin	67-76	ATP binding cassette subfamily B member 1	Homo sapiens	96-100
23422925-10	2013	CONCLUSIONS: Quercetin significantly induced the activity of P-gp and this induced effect was more obvious in MDR1 3435 TT individuals.	Quercetin	13-22	ATP binding cassette subfamily B member 1	Homo sapiens	61-65
23422925-10	2013	CONCLUSIONS: Quercetin significantly induced the activity of P-gp and this induced effect was more obvious in MDR1 3435 TT individuals.	Quercetin	13-22	ATP binding cassette subfamily B member 1	Homo sapiens	110-114
23295412-3	2013	Maternal intake of quercetin increased the expression of Nrf2 and Sod2 in fetal liver at gestational day 14.5.	Quercetin	19-28	superoxide dismutase 2, mitochondrial	Mus musculus	66-70
23231807-0	2013	Quercetin protects against the Abeta(25-35)-induced amnesic injury: involvement of inactivation of rage-mediated pathway and conservation of the NVU.	Quercetin	0-9	MOK protein kinase	Mus musculus	99-103
22983795-0	2013	p53 contributes to quercetin-induced apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.	Quercetin	19-28	tumor protein p53	Homo sapiens	0-3
22983795-3	2013	The cleavages of caspase-3 and caspase-9 and the accumulation of cytosolic cytochrome C were measured by western blot in quercetin-treated RAFLSs.	Quercetin	121-130	caspase 3	Homo sapiens	17-26
22983795-3	2013	The cleavages of caspase-3 and caspase-9 and the accumulation of cytosolic cytochrome C were measured by western blot in quercetin-treated RAFLSs.	Quercetin	121-130	caspase 9	Homo sapiens	31-40
22983795-3	2013	The cleavages of caspase-3 and caspase-9 and the accumulation of cytosolic cytochrome C were measured by western blot in quercetin-treated RAFLSs.	Quercetin	121-130	cytochrome c, somatic	Homo sapiens	75-87
22983795-6	2013	DNA fragmentation assay showed that quercetin dose-dependently elevated the apoptosis of RAFLSs, accompanying with enhanced caspase-3 and caspase-9 cleavages.	Quercetin	36-45	caspase 3	Homo sapiens	124-133
22983795-6	2013	DNA fragmentation assay showed that quercetin dose-dependently elevated the apoptosis of RAFLSs, accompanying with enhanced caspase-3 and caspase-9 cleavages.	Quercetin	36-45	caspase 9	Homo sapiens	138-147
22983795-7	2013	Moreover, quercetin caused a concentration-dependent loss of mitochondrial membrane potential and cytochrome c release to cytosol and also decreased Bcl-2/Bax ratio, indicating that quercetin-induced apoptosis is through mitochondrial pathway.	Quercetin	10-19	cytochrome c, somatic	Homo sapiens	98-110
22983795-7	2013	Moreover, quercetin caused a concentration-dependent loss of mitochondrial membrane potential and cytochrome c release to cytosol and also decreased Bcl-2/Bax ratio, indicating that quercetin-induced apoptosis is through mitochondrial pathway.	Quercetin	10-19	BCL2 apoptosis regulator	Homo sapiens	149-154
22983795-7	2013	Moreover, quercetin caused a concentration-dependent loss of mitochondrial membrane potential and cytochrome c release to cytosol and also decreased Bcl-2/Bax ratio, indicating that quercetin-induced apoptosis is through mitochondrial pathway.	Quercetin	10-19	BCL2 associated X, apoptosis regulator	Homo sapiens	155-158
22983795-7	2013	Moreover, quercetin caused a concentration-dependent loss of mitochondrial membrane potential and cytochrome c release to cytosol and also decreased Bcl-2/Bax ratio, indicating that quercetin-induced apoptosis is through mitochondrial pathway.	Quercetin	182-191	cytochrome c, somatic	Homo sapiens	98-110
22983795-7	2013	Moreover, quercetin caused a concentration-dependent loss of mitochondrial membrane potential and cytochrome c release to cytosol and also decreased Bcl-2/Bax ratio, indicating that quercetin-induced apoptosis is through mitochondrial pathway.	Quercetin	182-191	BCL2 apoptosis regulator	Homo sapiens	149-154
22983795-7	2013	Moreover, quercetin caused a concentration-dependent loss of mitochondrial membrane potential and cytochrome c release to cytosol and also decreased Bcl-2/Bax ratio, indicating that quercetin-induced apoptosis is through mitochondrial pathway.	Quercetin	182-191	BCL2 associated X, apoptosis regulator	Homo sapiens	155-158
22983795-8	2013	Quercetin also elevated p53 phosphorylation at ser15.	Quercetin	0-9	tumor protein p53	Homo sapiens	24-27
22983795-9	2013	Pretreatment with pifithrin-alpha, a p53 inhibitor, significantly diminished p53 phosphorylation at the concentration of 30 muM and abrogated quercetin-induced apoptosis in a dose-dependent manner.	Quercetin	142-151	tumor protein p53	Homo sapiens	37-40
22983795-10	2013	Quercetin-induced apoptosis was also significantly blocked by p53 silencing, further suggesting the involvement of p53 in quercetin-induced apoptosis in RAFLSs.	Quercetin	0-9	tumor protein p53	Homo sapiens	62-65
22983795-10	2013	Quercetin-induced apoptosis was also significantly blocked by p53 silencing, further suggesting the involvement of p53 in quercetin-induced apoptosis in RAFLSs.	Quercetin	0-9	tumor protein p53	Homo sapiens	115-118
22983795-10	2013	Quercetin-induced apoptosis was also significantly blocked by p53 silencing, further suggesting the involvement of p53 in quercetin-induced apoptosis in RAFLSs.	Quercetin	122-131	tumor protein p53	Homo sapiens	62-65
22983795-10	2013	Quercetin-induced apoptosis was also significantly blocked by p53 silencing, further suggesting the involvement of p53 in quercetin-induced apoptosis in RAFLSs.	Quercetin	122-131	tumor protein p53	Homo sapiens	115-118
22983795-11	2013	Our study indicated that quercetin-induced apoptosis of RAFLSs is through mitochondrial pathway, in which p53 plays an important role.	Quercetin	25-34	tumor protein p53	Homo sapiens	106-109
23097160-7	2013	Since the 3"-methylation of quercetin is induced by catechol-O-methyl transferase, the enzyme may regulate the intracellular activity of quercetin.	Quercetin	28-37	catechol-O-methyltransferase	Homo sapiens	52-81
23097160-7	2013	Since the 3"-methylation of quercetin is induced by catechol-O-methyl transferase, the enzyme may regulate the intracellular activity of quercetin.	Quercetin	137-146	catechol-O-methyltransferase	Homo sapiens	52-81
22882531-13	2013	Quercetin could noticeably elevate osteocalcin as a bone formation marker.	Quercetin	0-9	bone gamma-carboxyglutamate protein	Rattus norvegicus	35-46
23231807-10	2013	Our results demonstrate that quercetin treatment for Abeta(25-35)-induced amnesic mice improved the learning and memory capabilities and conferred robust neurovascular coupling protection, involving maintenance of the NVU integrity, reduction of neurovascular oxidation, modulation of microvascular function, improvement of cholinergic system, and regulation of neurovascular RAGE signaling pathway and ERK/CREB/BDNF pathway.	Quercetin	29-38	MOK protein kinase	Mus musculus	376-380
23231807-10	2013	Our results demonstrate that quercetin treatment for Abeta(25-35)-induced amnesic mice improved the learning and memory capabilities and conferred robust neurovascular coupling protection, involving maintenance of the NVU integrity, reduction of neurovascular oxidation, modulation of microvascular function, improvement of cholinergic system, and regulation of neurovascular RAGE signaling pathway and ERK/CREB/BDNF pathway.	Quercetin	29-38	mitogen-activated protein kinase 1	Mus musculus	403-406
23231807-10	2013	Our results demonstrate that quercetin treatment for Abeta(25-35)-induced amnesic mice improved the learning and memory capabilities and conferred robust neurovascular coupling protection, involving maintenance of the NVU integrity, reduction of neurovascular oxidation, modulation of microvascular function, improvement of cholinergic system, and regulation of neurovascular RAGE signaling pathway and ERK/CREB/BDNF pathway.	Quercetin	29-38	cAMP responsive element binding protein 1	Mus musculus	407-411
23231807-10	2013	Our results demonstrate that quercetin treatment for Abeta(25-35)-induced amnesic mice improved the learning and memory capabilities and conferred robust neurovascular coupling protection, involving maintenance of the NVU integrity, reduction of neurovascular oxidation, modulation of microvascular function, improvement of cholinergic system, and regulation of neurovascular RAGE signaling pathway and ERK/CREB/BDNF pathway.	Quercetin	29-38	brain derived neurotrophic factor	Mus musculus	412-416
23231807-12	2013	Quercetin protected the NVU likely through reduction of oxidative damage, inactivation of RAGE-mediated pathway and preservation of cholinergic neurons, offering an alternative medication for Alzheimer"s disease.	Quercetin	0-9	MOK protein kinase	Mus musculus	90-94
23396969-10	2013	DHA transport activity in GLUT2- and GLUT8-expressing oocytes was inhibited by glucose, fructose, and by the flavonoids phloretin and quercetin.	Quercetin	134-143	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	26-31
22850125-3	2013	Conversely, in vitro, naringenin and quercetin are described to inhibit phosphoinositide-3-kinase (PI3K), an enzyme that is essential for the neuronal control of whole body glucose homoeostasis.	Quercetin	37-46	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	72-97
22850125-5	2013	Quercetin was found to inhibit basal and insulin-induced phosphorylation of Akt (Ser473), a downstream target of PI3K, in HT-22 cells, whereas naringenin and curcumin had no effect.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	76-79
22850125-6	2013	In Djungarian hamsters (Phodopus sungorus) naringenin and quercetin (10 mg/kg administered orally) diminished insulin-induced phosphorylation of Akt (Ser473) in the arcuate nucleus, indicating a reduction in hypothalamic PI3K activity.	Quercetin	58-67	thymoma viral proto-oncogene 1	Mus musculus	145-148
23396969-10	2013	DHA transport activity in GLUT2- and GLUT8-expressing oocytes was inhibited by glucose, fructose, and by the flavonoids phloretin and quercetin.	Quercetin	134-143	solute carrier family 2, (facilitated glucose transporter), member 8	Mus musculus	37-42
23466865-4	2013	PSPLE, aspirin, cyanidin and quercetin significantly inhibited TNF-alpha-induced monocyte-endothelial cell adhesion (p &lt; 0.05).	Quercetin	29-38	tumor necrosis factor	Homo sapiens	63-72
23220257-6	2013	Quercetin administration also restored the activities of superoxide dismutase and catalase along with thiol content in 3-NP treated animals.	Quercetin	0-9	catalase	Rattus norvegicus	82-90
23265624-0	2013	Bilirubin participates in protecting of heme oxygenase-1 induction by quercetin against ethanol hepatotoxicity in cultured rat hepatocytes.	Quercetin	70-79	heme oxygenase 1	Rattus norvegicus	40-56
23265624-4	2013	Quercetin lowered ethanol-induced glutathione depletion and superoxide dismutase inactivation, inhibited the overproduction of malondialdehyde and reactive oxygen species, and decreased the leakage of cellular aspartate aminotransferase and lactate dehydrogenase, accompanying the normalization of bilirubin level.	Quercetin	0-9	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	210-236
23466865-5	2013	Cyanidin, quercetin and PSPLE also significantly attenuated VCAM-1, IL-8 and CD40 expression, and quercetin significantly attenuated ICAM-1 and E-selectin expression (p &lt; 0.05).	Quercetin	10-19	vascular cell adhesion molecule 1	Homo sapiens	60-66
23466865-5	2013	Cyanidin, quercetin and PSPLE also significantly attenuated VCAM-1, IL-8 and CD40 expression, and quercetin significantly attenuated ICAM-1 and E-selectin expression (p &lt; 0.05).	Quercetin	10-19	CD40 molecule	Homo sapiens	77-81
23466865-5	2013	Cyanidin, quercetin and PSPLE also significantly attenuated VCAM-1, IL-8 and CD40 expression, and quercetin significantly attenuated ICAM-1 and E-selectin expression (p &lt; 0.05).	Quercetin	98-107	intercellular adhesion molecule 1	Homo sapiens	133-139
23466865-5	2013	Cyanidin, quercetin and PSPLE also significantly attenuated VCAM-1, IL-8 and CD40 expression, and quercetin significantly attenuated ICAM-1 and E-selectin expression (p &lt; 0.05).	Quercetin	98-107	selectin E	Homo sapiens	144-154
23466865-6	2013	Significant reductions in NFkappaB expression and DNA binding by aspirin, cyanidin and quercetin were also observed in addition to decreased expression of ERK1, ERK2 and p38 MAPK (p &lt; 0.05).	Quercetin	87-96	nuclear factor kappa B subunit 1	Homo sapiens	26-34
23466865-7	2013	Thus, PSPLE and its components, cyanidin and quercetin, have anti-inflammatory effects through modulation of NFkappaB and MAPK signaling.	Quercetin	45-54	nuclear factor kappa B subunit 1	Homo sapiens	109-117
23466865-7	2013	Thus, PSPLE and its components, cyanidin and quercetin, have anti-inflammatory effects through modulation of NFkappaB and MAPK signaling.	Quercetin	45-54	mitogen-activated protein kinase 3	Homo sapiens	122-126
23249147-0	2013	Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway.	Quercetin	21-30	mitogen-activated protein kinase 8	Rattus norvegicus	123-126
22422628-3	2013	METHOD: ALDH1 activity of head and neck cancer cells with quercetin treatment was assessed by the Aldefluor assay flow cytometry analysis.	Quercetin	58-67	aldehyde dehydrogenase 1 family member A1	Homo sapiens	8-13
22422628-5	2013	RESULTS: We first observed that the treatment of quercetin significantly downregulated the ALDH1 activity of head and neck cancer cells in a dose-dependent manner (p &lt; .05).	Quercetin	49-58	aldehyde dehydrogenase 1 family member A1	Homo sapiens	91-96
22422628-7	2013	The migration ability of head and neck cancer-derived sphere cells was lessened under quercetin treatment partially due to the decreased productions of Twist, N-cadherin, and vimentin.	Quercetin	86-95	cadherin 2	Homo sapiens	159-169
22422628-7	2013	The migration ability of head and neck cancer-derived sphere cells was lessened under quercetin treatment partially due to the decreased productions of Twist, N-cadherin, and vimentin.	Quercetin	86-95	vimentin	Homo sapiens	175-183
24170973-4	2013	Two derivatives of the flavonoid quercetin (Q), chloronaphthoquinone quercetin (CNC) and monochloropivaloyl quercetin (MCP), showed improved antioxidant properties and moreover, they efficiently inhibited aldose reductase activity in vitro.	Quercetin	33-42	aldo-keto reductase family 1 member B1	Rattus norvegicus	205-221
23662249-8	2013	Thus, our study has identified LSD1 as a novel target of bioactive natural compounds, such as resveratrol, curcumin and quercetin, and such finding suggests that LSD1 inhibition can at least partially contribute to some of the previously observed beneficial effects of these compounds.	Quercetin	120-129	lysine demethylase 1A	Homo sapiens	31-35
23662249-8	2013	Thus, our study has identified LSD1 as a novel target of bioactive natural compounds, such as resveratrol, curcumin and quercetin, and such finding suggests that LSD1 inhibition can at least partially contribute to some of the previously observed beneficial effects of these compounds.	Quercetin	120-129	lysine demethylase 1A	Homo sapiens	162-166
23662249-4	2013	Here, we studied the effect of natural polyphenols resveratrol, curcumin, quercetin and analogs on LSD1.	Quercetin	74-83	lysine demethylase 1A	Homo sapiens	99-103
23662249-5	2013	Using in vitro LSD1 enzymatic assays, we show that resveratrol, curcumin and quercetin displayed a potent inhibitory effect on the LSD1 activity and were more potent than the known LSD1 inhibitor trans-2-phenylcyclopropylamine (TCP).	Quercetin	77-86	lysine demethylase 1A	Homo sapiens	15-19
23662249-5	2013	Using in vitro LSD1 enzymatic assays, we show that resveratrol, curcumin and quercetin displayed a potent inhibitory effect on the LSD1 activity and were more potent than the known LSD1 inhibitor trans-2-phenylcyclopropylamine (TCP).	Quercetin	77-86	lysine demethylase 1A	Homo sapiens	131-135
23662249-5	2013	Using in vitro LSD1 enzymatic assays, we show that resveratrol, curcumin and quercetin displayed a potent inhibitory effect on the LSD1 activity and were more potent than the known LSD1 inhibitor trans-2-phenylcyclopropylamine (TCP).	Quercetin	77-86	lysine demethylase 1A	Homo sapiens	131-135
23249147-0	2013	Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway.	Quercetin	21-30	AKT serine/threonine kinase 1	Rattus norvegicus	136-139
23249147-11	2013	Additionally, quercetin dramatically increased Phosphoinositide-3-kinase (PI3K) and phosphorylated protein kinase B (PKB/Akt) levels in liver rats.	Quercetin	14-23	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	47-72
23249147-11	2013	Additionally, quercetin dramatically increased Phosphoinositide-3-kinase (PI3K) and phosphorylated protein kinase B (PKB/Akt) levels in liver rats.	Quercetin	14-23	AKT serine/threonine kinase 1	Rattus norvegicus	121-124
23249147-12	2013	In the examined unfolded protein response (UPR) pathways, quercetin markedly inhibited the Pb-induced increase of the phosphorylated inositol-requiring enzyme 1 (IRE1) and c-jun N-terminal kinase (JNK) in rat liver.	Quercetin	58-67	mitogen-activated protein kinase 8	Rattus norvegicus	172-195
23249147-12	2013	In the examined unfolded protein response (UPR) pathways, quercetin markedly inhibited the Pb-induced increase of the phosphorylated inositol-requiring enzyme 1 (IRE1) and c-jun N-terminal kinase (JNK) in rat liver.	Quercetin	58-67	mitogen-activated protein kinase 8	Rattus norvegicus	197-200
23249147-13	2013	Taken together, these results suggested that the inhibition of Pb-induced ER stress by quercetin is due at least in part to its anti-oxidant stress activity and its ability to modulate the PI3K/Akt and IRE1/JNK signaling pathway.	Quercetin	87-96	AKT serine/threonine kinase 1	Rattus norvegicus	194-197
23249147-13	2013	Taken together, these results suggested that the inhibition of Pb-induced ER stress by quercetin is due at least in part to its anti-oxidant stress activity and its ability to modulate the PI3K/Akt and IRE1/JNK signaling pathway.	Quercetin	87-96	mitogen-activated protein kinase 8	Rattus norvegicus	207-210
23206800-5	2013	While both tea catechins and quercetin strongly inhibit human liver catechol-O-methyltransferase (COMT)-mediated O-methylation of L-DOPA in vitro, only (+)-catechin exerts a significant inhibition of L-DOPA methylation in both peripheral compartment and striatum in rats.	Quercetin	29-38	catechol-O-methyltransferase	Homo sapiens	68-96
23292678-10	2013	In addition, a polyphenolic             flavonoid compound, quercetin, known to inhibit FASN, was found to inhibit proliferation             of NPC cells.	Quercetin	60-69	fatty acid synthase	Homo sapiens	88-92
23348005-0	2013	Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells.	Quercetin	0-9	insulin	Homo sapiens	21-28
23348005-7	2013	Quercetin (10 muM) increased cell proliferation by 3.05 folds with decreased TAG content (45%) and was effective in increasing insulin mediated glucose uptake by 2.65 folds.	Quercetin	0-9	latexin	Homo sapiens	14-17
23348005-7	2013	Quercetin (10 muM) increased cell proliferation by 3.05 folds with decreased TAG content (45%) and was effective in increasing insulin mediated glucose uptake by 2.65 folds.	Quercetin	0-9	insulin	Homo sapiens	127-134
23348005-9	2013	Quercetin (10 muM) decreased TNF-alpha and IL-8 by 59.74% and 41.11% respectively and inhibited generation of lipid peroxides by 50.5%.	Quercetin	0-9	latexin	Homo sapiens	14-17
23348005-9	2013	Quercetin (10 muM) decreased TNF-alpha and IL-8 by 59.74% and 41.11% respectively and inhibited generation of lipid peroxides by 50.5%.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	29-38
23348005-9	2013	Quercetin (10 muM) decreased TNF-alpha and IL-8 by 59.74% and 41.11% respectively and inhibited generation of lipid peroxides by 50.5%.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
23348005-10	2013	In addition, RT-PCR results confirmed quercetin (10 muM) inhibited TNF-alpha gene expression.	Quercetin	38-47	latexin	Homo sapiens	52-55
23348005-10	2013	In addition, RT-PCR results confirmed quercetin (10 muM) inhibited TNF-alpha gene expression.	Quercetin	38-47	tumor necrosis factor	Homo sapiens	67-76
23348005-12	2013	Albumin and urea content was increased while the alanine aminotransferase (ALAT) activity was significantly decreased by quercetin.	Quercetin	121-130	glutamic--pyruvic transaminase	Homo sapiens	49-73
23348005-12	2013	Albumin and urea content was increased while the alanine aminotransferase (ALAT) activity was significantly decreased by quercetin.	Quercetin	121-130	glutamic--pyruvic transaminase	Homo sapiens	75-79
23348005-13	2013	Hence, quercetin effectively reversed NAFLD symptoms by decreased triacyl glycerol accumulation, insulin resistance, inflammatory cytokine secretion and increased cellular antioxidants in OA induced hepatic steatosis in HepG2 cells.	Quercetin	7-16	insulin	Homo sapiens	97-104
23849943-0	2013	[Impact of quercetin on the expression of heparanase in cervical cancer cells].	Quercetin	11-20	heparanase	Homo sapiens	42-52
23849943-1	2013	OBJECTIVE: To detect the expression of heparanase (HPA) in cervical cancer cells and investigate the impact of quercetin on the expression of HPA, and the molecular mechanism that quercetin inhibits the growth of cervical cancer cells.	Quercetin	111-120	heparanase	Homo sapiens	142-145
23849943-1	2013	OBJECTIVE: To detect the expression of heparanase (HPA) in cervical cancer cells and investigate the impact of quercetin on the expression of HPA, and the molecular mechanism that quercetin inhibits the growth of cervical cancer cells.	Quercetin	180-189	heparanase	Homo sapiens	39-49
23849943-1	2013	OBJECTIVE: To detect the expression of heparanase (HPA) in cervical cancer cells and investigate the impact of quercetin on the expression of HPA, and the molecular mechanism that quercetin inhibits the growth of cervical cancer cells.	Quercetin	180-189	heparanase	Homo sapiens	51-54
23849943-1	2013	OBJECTIVE: To detect the expression of heparanase (HPA) in cervical cancer cells and investigate the impact of quercetin on the expression of HPA, and the molecular mechanism that quercetin inhibits the growth of cervical cancer cells.	Quercetin	180-189	heparanase	Homo sapiens	142-145
23849943-6	2013	(2) The real-time PCR shows as follows: as the quercetin concentration increased (20, 40 and 80 micromol/L), the mRNA expression level of HPA decreased (P &lt; 0.01), in which the inhibition of HPA expression was concentration dependent.	Quercetin	47-56	heparanase	Homo sapiens	138-141
23849943-6	2013	(2) The real-time PCR shows as follows: as the quercetin concentration increased (20, 40 and 80 micromol/L), the mRNA expression level of HPA decreased (P &lt; 0.01), in which the inhibition of HPA expression was concentration dependent.	Quercetin	47-56	heparanase	Homo sapiens	194-197
23849943-9	2013	Compared with negative control group, the expression level of HPA mRNA decreased in different concentrations of quercetin (40 and 80 micromol/L) in both HeLa and Caski cells (all P &lt; 0.05); Compared with positive control group, the expression level of HPA mRNA expressed no obvious difference in quercetin (80 micromol/L) group (P &gt; 0.05) in HeLa cells, while it was opposite in Caski cells (P &lt; 0.01).	Quercetin	112-121	heparanase	Homo sapiens	62-65
23849943-9	2013	Compared with negative control group, the expression level of HPA mRNA decreased in different concentrations of quercetin (40 and 80 micromol/L) in both HeLa and Caski cells (all P &lt; 0.05); Compared with positive control group, the expression level of HPA mRNA expressed no obvious difference in quercetin (80 micromol/L) group (P &gt; 0.05) in HeLa cells, while it was opposite in Caski cells (P &lt; 0.01).	Quercetin	299-308	heparanase	Homo sapiens	62-65
23849943-10	2013	(3) The result of western blot shown that, as the quercetin concentration increased (20, 40 and 80 micromol/L) and time growth (24, 48 and 72 hours), the expression level of HPA protein decreased (P &lt; 0.01), and the inhibition of HPA protein expression was concentration and time dependent.	Quercetin	50-59	heparanase	Homo sapiens	174-177
23849943-10	2013	(3) The result of western blot shown that, as the quercetin concentration increased (20, 40 and 80 micromol/L) and time growth (24, 48 and 72 hours), the expression level of HPA protein decreased (P &lt; 0.01), and the inhibition of HPA protein expression was concentration and time dependent.	Quercetin	50-59	heparanase	Homo sapiens	233-236
23849943-11	2013	Compared with negative control group, the expression level of HPA protein decreased in different concentrations of quercetin (40 and 80 micromol/L) in both HeLa and Caski cells (all P &lt; 0.05); Compared with positive control group, the expression level of HPA protein expressed no obvious difference in quercetin (80 micromol/L) group (all P &gt; 0.05) in both HeLa cells and Caski cells (all P &gt; 0.05).	Quercetin	115-124	heparanase	Homo sapiens	62-65
23849943-11	2013	Compared with negative control group, the expression level of HPA protein decreased in different concentrations of quercetin (40 and 80 micromol/L) in both HeLa and Caski cells (all P &lt; 0.05); Compared with positive control group, the expression level of HPA protein expressed no obvious difference in quercetin (80 micromol/L) group (all P &gt; 0.05) in both HeLa cells and Caski cells (all P &gt; 0.05).	Quercetin	305-314	heparanase	Homo sapiens	62-65
23849943-12	2013	CONCLUSION: Quercetin could inhibits the expression of HPA in cervical carcinoma cell lines, which inhibition is concentration and time dependent.	Quercetin	12-21	heparanase	Homo sapiens	55-58
23440277-5	2013	In a screen of biological metabolites, we have now identified four flavonoids as potentiators of EAG1 channels: fisetin, quercetin, luteolin, and kaempferol.	Quercetin	121-130	potassium voltage-gated channel subfamily H member 1	Homo sapiens	97-101
23206800-5	2013	While both tea catechins and quercetin strongly inhibit human liver catechol-O-methyltransferase (COMT)-mediated O-methylation of L-DOPA in vitro, only (+)-catechin exerts a significant inhibition of L-DOPA methylation in both peripheral compartment and striatum in rats.	Quercetin	29-38	catechol-O-methyltransferase	Homo sapiens	98-102
23581983-7	2013	Widely known natural Keap1-Nrf2 activators include curcumin, quercetin, resveratrol, and sulforaphane.	Quercetin	61-70	kelch like ECH associated protein 1	Homo sapiens	21-26
23353651-5	2013	In addition, quercetin-treated macrophages inhibited lipopolysaccharide-induced activation of mitogen-activated protein kinases, such as extracellular signal-regulated kinase 1/2, p38, and c-Jun N-terminal kinase, and the translocation of nuclear factor-kappaB and p65 through Toll-interacting protein.	Quercetin	13-22	mitogen-activated protein kinase 3	Homo sapiens	137-178
23353651-5	2013	In addition, quercetin-treated macrophages inhibited lipopolysaccharide-induced activation of mitogen-activated protein kinases, such as extracellular signal-regulated kinase 1/2, p38, and c-Jun N-terminal kinase, and the translocation of nuclear factor-kappaB and p65 through Toll-interacting protein.	Quercetin	13-22	mitogen-activated protein kinase 14	Homo sapiens	180-183
23353651-5	2013	In addition, quercetin-treated macrophages inhibited lipopolysaccharide-induced activation of mitogen-activated protein kinases, such as extracellular signal-regulated kinase 1/2, p38, and c-Jun N-terminal kinase, and the translocation of nuclear factor-kappaB and p65 through Toll-interacting protein.	Quercetin	13-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	265-268
23353651-6	2013	Treatment with quercetin resulted in a significant decrease in prostaglandin E2 and cyclooxygenase-2 levels as well as inducible nitric oxide synthase-mediated nitric oxide production induced by lipopolysaccharide.	Quercetin	15-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	84-100
23353651-0	2013	Quercetin negatively regulates TLR4 signaling induced by lipopolysaccharide through Tollip expression.	Quercetin	0-9	toll like receptor 4	Homo sapiens	31-35
23353651-0	2013	Quercetin negatively regulates TLR4 signaling induced by lipopolysaccharide through Tollip expression.	Quercetin	0-9	toll interacting protein	Homo sapiens	84-90
23353651-2	2013	In this study, we showed the molecular basis for the downregulation of TLR4 signal transduction by quercetin.	Quercetin	99-108	toll like receptor 4	Homo sapiens	71-75
23353651-3	2013	Quercetin markedly elevated the expression of the Toll-interacting protein, a negative regulator of TLR signaling.	Quercetin	0-9	toll like receptor 4	Homo sapiens	100-103
23353651-4	2013	Lipopolysaccharide-induced expression of cell surface molecules (CD80, CD86, and MHC class I/II) and production of pro-inflammatory cytokines (tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-12p70) were inhibited by quercetin, and this action was prevented by Toll-interacting protein silencing.	Quercetin	220-229	tumor necrosis factor	Homo sapiens	115-170
23294286-1	2013	Quercetin and gallic acid are natural activators of the transcription factor Nrf2, which regulates the expression of many cytoprotective enzymes including heme oxygenase-1 (HO-1).	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
23294286-1	2013	Quercetin and gallic acid are natural activators of the transcription factor Nrf2, which regulates the expression of many cytoprotective enzymes including heme oxygenase-1 (HO-1).	Quercetin	0-9	heme oxygenase 1	Mus musculus	155-171
23294286-1	2013	Quercetin and gallic acid are natural activators of the transcription factor Nrf2, which regulates the expression of many cytoprotective enzymes including heme oxygenase-1 (HO-1).	Quercetin	0-9	heme oxygenase 1	Mus musculus	173-177
22721393-7	2013	Compared to treatment with doxorubicin alone, combined treatment with doxorubicin and quercetin (0.7 muM) significantly inhibited cell proliferation and invasion and suppressed the expression of HIF-1alpha and P-gp.	Quercetin	86-95	latexin	Homo sapiens	101-104
22721393-7	2013	Compared to treatment with doxorubicin alone, combined treatment with doxorubicin and quercetin (0.7 muM) significantly inhibited cell proliferation and invasion and suppressed the expression of HIF-1alpha and P-gp.	Quercetin	86-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	195-205
22721393-7	2013	Compared to treatment with doxorubicin alone, combined treatment with doxorubicin and quercetin (0.7 muM) significantly inhibited cell proliferation and invasion and suppressed the expression of HIF-1alpha and P-gp.	Quercetin	86-95	ATP binding cassette subfamily B member 1	Homo sapiens	210-214
22721393-8	2013	Quercetin (0.7 muM) increased the intracellular doxorubicin concentration and enhanced doxorubicin cytotoxicity as 1.49-fold in MCF-7 cells and 1.98-fold in MCF-7/dox cells.	Quercetin	0-9	latexin	Homo sapiens	15-18
23581983-7	2013	Widely known natural Keap1-Nrf2 activators include curcumin, quercetin, resveratrol, and sulforaphane.	Quercetin	61-70	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
23467948-9	2013	RESULTS: Quercetin (50 mg/kg) and rutin (10 mg/kg) administered 10 min before reperfusion resulted in significant reduction of infarct size, MDA, and MPO levels and significant increase in SOD and CAT levels.	Quercetin	9-18	myeloperoxidase	Rattus norvegicus	150-153
23231348-10	2013	Adding glutathione to the detergent-based assay, as used in these studies to measure furin processing activity, strongly reduced inhibition by a number of polyphenols (catechins, gallic acid and quercetin), while the effect on the genuine inhibitor nona-D-arginine remained unchanged.	Quercetin	195-204	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
23467948-9	2013	RESULTS: Quercetin (50 mg/kg) and rutin (10 mg/kg) administered 10 min before reperfusion resulted in significant reduction of infarct size, MDA, and MPO levels and significant increase in SOD and CAT levels.	Quercetin	9-18	catalase	Rattus norvegicus	197-200
23123425-7	2013	The results showed that oral administration of quercetin at doses of 30-60 mg/kg to hyperlipidemia rats for 14 days were highly effective in decreasing the levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Quercetin	47-56	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	296-322
22843013-8	2013	Quercetin, luteolin, and EGCG inhibited inflammation-evoked IKKbeta activation and IRS-1 serine phosphorylation in adipose tissue, and thereby effectively restored glucose load-stimulated IRS-1 tyrosine and Akt phosphorylation, leading to an increase in insulin-mediated glucose uptake in adipocytes.	Quercetin	0-9	inhibitor of kappaB kinase beta	Mus musculus	60-67
22843013-8	2013	Quercetin, luteolin, and EGCG inhibited inflammation-evoked IKKbeta activation and IRS-1 serine phosphorylation in adipose tissue, and thereby effectively restored glucose load-stimulated IRS-1 tyrosine and Akt phosphorylation, leading to an increase in insulin-mediated glucose uptake in adipocytes.	Quercetin	0-9	insulin receptor substrate 1	Mus musculus	83-88
22843013-8	2013	Quercetin, luteolin, and EGCG inhibited inflammation-evoked IKKbeta activation and IRS-1 serine phosphorylation in adipose tissue, and thereby effectively restored glucose load-stimulated IRS-1 tyrosine and Akt phosphorylation, leading to an increase in insulin-mediated glucose uptake in adipocytes.	Quercetin	0-9	insulin receptor substrate 1	Mus musculus	188-193
22843013-8	2013	Quercetin, luteolin, and EGCG inhibited inflammation-evoked IKKbeta activation and IRS-1 serine phosphorylation in adipose tissue, and thereby effectively restored glucose load-stimulated IRS-1 tyrosine and Akt phosphorylation, leading to an increase in insulin-mediated glucose uptake in adipocytes.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	207-210
23333628-9	2013	Quercetin also inhibited histamine- or PMA-induced phosphorylation of Tyr(311) of PKCdelta and translocation of PKCdelta to the Golgi.	Quercetin	0-9	protein kinase C delta	Homo sapiens	82-90
23333628-9	2013	Quercetin also inhibited histamine- or PMA-induced phosphorylation of Tyr(311) of PKCdelta and translocation of PKCdelta to the Golgi.	Quercetin	0-9	protein kinase C delta	Homo sapiens	112-120
23333628-10	2013	Pre-treatment with quercetin for 3weeks suppressed TDI-induced nasal allergy-like symptoms and elevation of H1R mRNA in the nasal mucosa of TDI-sensitized rats.	Quercetin	19-28	histamine receptor H 1	Rattus norvegicus	108-111
23333628-11	2013	These data suggest that quercetin suppresses H1R gene expression by the suppression of PKCdelta activation through the inhibition of its translocation to the Golgi.	Quercetin	24-33	histamine receptor H 1	Rattus norvegicus	45-48
23333628-11	2013	These data suggest that quercetin suppresses H1R gene expression by the suppression of PKCdelta activation through the inhibition of its translocation to the Golgi.	Quercetin	24-33	protein kinase C delta	Homo sapiens	87-95
23333628-0	2013	Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-delta/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells.	Quercetin	0-9	histamine receptor H1	Homo sapiens	52-73
23333628-5	2013	However, effect of quercetin on H1R signaling is remained unknown.	Quercetin	19-28	histamine receptor H1	Homo sapiens	32-35
23333628-6	2013	In the present study, we examined the effect of quercetin on histamine- and PMA-induced up-regulation of H1R gene expression in HeLa cells.	Quercetin	48-57	histamine receptor H1	Homo sapiens	105-108
23333628-8	2013	Quercetin suppressed histamine- and PMA-induced up-regulation of H1R gene expression.	Quercetin	0-9	histamine receptor H1	Homo sapiens	65-68
23123425-7	2013	The results showed that oral administration of quercetin at doses of 30-60 mg/kg to hyperlipidemia rats for 14 days were highly effective in decreasing the levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Quercetin	47-56	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	324-327
23188647-3	2013	The flavonoids, naringin, naringenin, and quercetin, were subsequently incubated with felodipine at the determined K(m) value in HLM.	Quercetin	42-51	oxysterol binding protein 2	Homo sapiens	129-132
23192864-9	2013	Moreover, the flavonoids equol and quercetin exhibited interaction with all ruminant ABCG2 clones.	Quercetin	35-44	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	85-90
27481281-2	2013	Quercetin and taxifolin bind to p53 binding hydrophobic groove of MDM2, and alter the conformation of groove as evidenced by 65 ns molecular dynamics simulation.	Quercetin	0-9	tumor protein p53	Homo sapiens	32-35
27481281-2	2013	Quercetin and taxifolin bind to p53 binding hydrophobic groove of MDM2, and alter the conformation of groove as evidenced by 65 ns molecular dynamics simulation.	Quercetin	0-9	MDM2 proto-oncogene	Homo sapiens	66-70
23399664-0	2013	Quercetin up-regulates expressions of peroxisome proliferator-activated receptor gamma, liver X receptor alpha, and ATP binding cassette transporter A1 genes and increases cholesterol efflux in human macrophage cell line.	Quercetin	0-9	ATP binding cassette subfamily A member 1	Homo sapiens	116-151
23399664-0	2013	Quercetin up-regulates expressions of peroxisome proliferator-activated receptor gamma, liver X receptor alpha, and ATP binding cassette transporter A1 genes and increases cholesterol efflux in human macrophage cell line.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	38-110
23399664-2	2013	We hypothesized that quercetin could lower the content of cholesterol in macrophages by regulating the expression of the ATP binding cassette transporter A1 (ABCA1) gene in differentiated human acute monocyte leukemia cell line (THP-1) cells and thereby reducing the chance of forming foam cells.	Quercetin	21-30	ATP binding cassette subfamily A member 1	Homo sapiens	121-156
23399664-2	2013	We hypothesized that quercetin could lower the content of cholesterol in macrophages by regulating the expression of the ATP binding cassette transporter A1 (ABCA1) gene in differentiated human acute monocyte leukemia cell line (THP-1) cells and thereby reducing the chance of forming foam cells.	Quercetin	21-30	ATP binding cassette subfamily A member 1	Homo sapiens	158-163
23399664-2	2013	We hypothesized that quercetin could lower the content of cholesterol in macrophages by regulating the expression of the ATP binding cassette transporter A1 (ABCA1) gene in differentiated human acute monocyte leukemia cell line (THP-1) cells and thereby reducing the chance of forming foam cells.	Quercetin	21-30	GLI family zinc finger 2	Homo sapiens	229-234
23399664-3	2013	Quercetin, in concentrations up to 30 muM, was not cytotoxic to differentiated THP-1 cells.	Quercetin	0-9	latexin	Homo sapiens	38-41
23399664-4	2013	Quercetin up-regulated both ABCA1 messenger RNA and protein expression in differentiated THP-1 cells, and its maximum effects were demonstrated at 0.3 muM for 4 to 8 hours in incubation.	Quercetin	0-9	ATP binding cassette subfamily A member 1	Homo sapiens	28-33
23399664-4	2013	Quercetin up-regulated both ABCA1 messenger RNA and protein expression in differentiated THP-1 cells, and its maximum effects were demonstrated at 0.3 muM for 4 to 8 hours in incubation.	Quercetin	0-9	GLI family zinc finger 2	Homo sapiens	89-94
23399664-4	2013	Quercetin up-regulated both ABCA1 messenger RNA and protein expression in differentiated THP-1 cells, and its maximum effects were demonstrated at 0.3 muM for 4 to 8 hours in incubation.	Quercetin	0-9	latexin	Homo sapiens	151-154
23399664-5	2013	In addition, quercetin increased protein levels of peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha (LXRalpha) within 2 hours of treatment.	Quercetin	13-22	peroxisome proliferator activated receptor gamma	Homo sapiens	51-99
23399664-5	2013	In addition, quercetin increased protein levels of peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha (LXRalpha) within 2 hours of treatment.	Quercetin	13-22	peroxisome proliferator activated receptor gamma	Homo sapiens	101-110
23399664-5	2013	In addition, quercetin increased protein levels of peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha (LXRalpha) within 2 hours of treatment.	Quercetin	13-22	nuclear receptor subfamily 1 group H member 3	Homo sapiens	140-148
23399664-6	2013	Because PPARgamma and LXRalpha are important transcriptional factors for ABCA1, quercetin-induced up-regulation of ABCA1 may be mediated by increased expression levels of the PPARgamma and LXRalpha genes.	Quercetin	80-89	peroxisome proliferator activated receptor gamma	Homo sapiens	8-17
23399664-6	2013	Because PPARgamma and LXRalpha are important transcriptional factors for ABCA1, quercetin-induced up-regulation of ABCA1 may be mediated by increased expression levels of the PPARgamma and LXRalpha genes.	Quercetin	80-89	nuclear receptor subfamily 1 group H member 3	Homo sapiens	22-30
23399664-6	2013	Because PPARgamma and LXRalpha are important transcriptional factors for ABCA1, quercetin-induced up-regulation of ABCA1 may be mediated by increased expression levels of the PPARgamma and LXRalpha genes.	Quercetin	80-89	ATP binding cassette subfamily A member 1	Homo sapiens	73-78
23399664-6	2013	Because PPARgamma and LXRalpha are important transcriptional factors for ABCA1, quercetin-induced up-regulation of ABCA1 may be mediated by increased expression levels of the PPARgamma and LXRalpha genes.	Quercetin	80-89	ATP binding cassette subfamily A member 1	Homo sapiens	115-120
23399664-6	2013	Because PPARgamma and LXRalpha are important transcriptional factors for ABCA1, quercetin-induced up-regulation of ABCA1 may be mediated by increased expression levels of the PPARgamma and LXRalpha genes.	Quercetin	80-89	peroxisome proliferator activated receptor gamma	Homo sapiens	175-184
23399664-6	2013	Because PPARgamma and LXRalpha are important transcriptional factors for ABCA1, quercetin-induced up-regulation of ABCA1 may be mediated by increased expression levels of the PPARgamma and LXRalpha genes.	Quercetin	80-89	nuclear receptor subfamily 1 group H member 3	Homo sapiens	189-197
23399664-7	2013	Furthermore, quercetin-enhanced cholesterol efflux from differentiated THP-1 cells to both high-density lipoprotein (HDL) and apolipoprotein A1.	Quercetin	13-22	GLI family zinc finger 2	Homo sapiens	71-76
23399664-7	2013	Furthermore, quercetin-enhanced cholesterol efflux from differentiated THP-1 cells to both high-density lipoprotein (HDL) and apolipoprotein A1.	Quercetin	13-22	apolipoprotein A1	Homo sapiens	126-143
23399664-8	2013	Quercetin at the dose of 0.15 muM elevated the cholesterol efflux only for HDL.	Quercetin	0-9	latexin	Homo sapiens	30-33
23399664-9	2013	At the dose of 0.3 muM, quercetin demonstrated effects both on HDL and apolipoprotein A1.	Quercetin	24-33	latexin	Homo sapiens	19-22
23399664-9	2013	At the dose of 0.3 muM, quercetin demonstrated effects both on HDL and apolipoprotein A1.	Quercetin	24-33	apolipoprotein A1	Homo sapiens	71-88
23399664-10	2013	Our data demonstrated that quercetin increased the expressions of PPARgamma, LXRalpha, and ABCA1 genes and cholesterol efflux from THP-1 macrophages.	Quercetin	27-36	peroxisome proliferator activated receptor gamma	Homo sapiens	66-75
23399664-10	2013	Our data demonstrated that quercetin increased the expressions of PPARgamma, LXRalpha, and ABCA1 genes and cholesterol efflux from THP-1 macrophages.	Quercetin	27-36	nuclear receptor subfamily 1 group H member 3	Homo sapiens	77-85
23399664-10	2013	Our data demonstrated that quercetin increased the expressions of PPARgamma, LXRalpha, and ABCA1 genes and cholesterol efflux from THP-1 macrophages.	Quercetin	27-36	ATP binding cassette subfamily A member 1	Homo sapiens	91-96
23399664-10	2013	Our data demonstrated that quercetin increased the expressions of PPARgamma, LXRalpha, and ABCA1 genes and cholesterol efflux from THP-1 macrophages.	Quercetin	27-36	GLI family zinc finger 2	Homo sapiens	131-136
23399664-11	2013	Quercetin-induced expression of PPARgamma and LXRalpha might subsequently affect up-regulation of their target gene ABCA1.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	32-41
23399664-11	2013	Quercetin-induced expression of PPARgamma and LXRalpha might subsequently affect up-regulation of their target gene ABCA1.	Quercetin	0-9	nuclear receptor subfamily 1 group H member 3	Homo sapiens	46-54
23399664-11	2013	Quercetin-induced expression of PPARgamma and LXRalpha might subsequently affect up-regulation of their target gene ABCA1.	Quercetin	0-9	ATP binding cassette subfamily A member 1	Homo sapiens	116-121
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	forkhead box O3	Mus musculus	10-16
23099361-13	2013	Quercetin restores nuclear FoxO3A and reduces chemokine expression partly by modulating EGFR/PI 3-kinase/Akt activity.	Quercetin	0-9	forkhead box O3	Mus musculus	27-33
23223575-5	2013	In the presence of quercetin, reactivation of beta-catenin using the glycogen synthase kinase-3beta (GSK-3beta) inhibitor LiCl restores calcium accumulation, confirming that quercetin mechanism of action hinges on inhibition of the beta-catenin pathway.	Quercetin	19-28	catenin beta 1	Homo sapiens	46-58
23099361-13	2013	Quercetin restores nuclear FoxO3A and reduces chemokine expression partly by modulating EGFR/PI 3-kinase/Akt activity.	Quercetin	0-9	epidermal growth factor receptor	Mus musculus	88-92
23099361-13	2013	Quercetin restores nuclear FoxO3A and reduces chemokine expression partly by modulating EGFR/PI 3-kinase/Akt activity.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	105-108
23663887-10	2013	Compared to the model group, quercetin treatment (both low- and high-dose) led to significant decreases in the liver index, FBG and IL-18 (all, P less than 0.01), and significant increase in IL-10 (P less than 0.05); however, the changes in liver index, FBG and IL-10 were not significantly different between the low- and high-dose treatment groups, but the high-dose of quercetin did induce a significantly greater decrease in IL-18 than the low-dose (P less than 0.05).	Quercetin	29-38	interleukin 18	Rattus norvegicus	132-137
23663887-10	2013	Compared to the model group, quercetin treatment (both low- and high-dose) led to significant decreases in the liver index, FBG and IL-18 (all, P less than 0.01), and significant increase in IL-10 (P less than 0.05); however, the changes in liver index, FBG and IL-10 were not significantly different between the low- and high-dose treatment groups, but the high-dose of quercetin did induce a significantly greater decrease in IL-18 than the low-dose (P less than 0.05).	Quercetin	29-38	interleukin 10	Rattus norvegicus	191-196
23663887-10	2013	Compared to the model group, quercetin treatment (both low- and high-dose) led to significant decreases in the liver index, FBG and IL-18 (all, P less than 0.01), and significant increase in IL-10 (P less than 0.05); however, the changes in liver index, FBG and IL-10 were not significantly different between the low- and high-dose treatment groups, but the high-dose of quercetin did induce a significantly greater decrease in IL-18 than the low-dose (P less than 0.05).	Quercetin	29-38	interleukin 10	Rattus norvegicus	262-267
23663887-10	2013	Compared to the model group, quercetin treatment (both low- and high-dose) led to significant decreases in the liver index, FBG and IL-18 (all, P less than 0.01), and significant increase in IL-10 (P less than 0.05); however, the changes in liver index, FBG and IL-10 were not significantly different between the low- and high-dose treatment groups, but the high-dose of quercetin did induce a significantly greater decrease in IL-18 than the low-dose (P less than 0.05).	Quercetin	29-38	interleukin 18	Rattus norvegicus	428-433
23223575-4	2013	However, beta-catenin activity is important because inhibition of beta-catenin with shRNA or bioflavonoid quercetin prevents calcification in primary human VSMCs, rodent aortic rings, and rat A10 VSMC line.	Quercetin	106-115	catenin beta 1	Homo sapiens	9-21
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	epidermal growth factor receptor	Mus musculus	80-84
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	forkhead box O3	Mus musculus	94-100
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	forkhead box O3	Mus musculus	94-100
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	chemokine (C-X-C motif) ligand 15	Mus musculus	192-196
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	thymoma viral proto-oncogene 1	Mus musculus	220-223
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	epidermal growth factor receptor	Mus musculus	225-229
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	forkhead box O3	Mus musculus	94-100
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	forkhead box O3	Mus musculus	94-100
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	epidermal growth factor receptor	Mus musculus	225-229
23099361-10	2013	Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.	Quercetin	120-129	thymoma viral proto-oncogene 1	Mus musculus	220-223
23211630-6	2013	Lithium (Li), an inhibitor of GSK-3beta, recovered Y27632-decreased proliferation and quercetin (Que), an inhibitor of beta-catenin pathway, reversed the recovery effect of Li.	Quercetin	86-95	catenin beta 1	Homo sapiens	119-131
23223575-5	2013	In the presence of quercetin, reactivation of beta-catenin using the glycogen synthase kinase-3beta (GSK-3beta) inhibitor LiCl restores calcium accumulation, confirming that quercetin mechanism of action hinges on inhibition of the beta-catenin pathway.	Quercetin	174-183	catenin beta 1	Homo sapiens	46-58
23223575-5	2013	In the presence of quercetin, reactivation of beta-catenin using the glycogen synthase kinase-3beta (GSK-3beta) inhibitor LiCl restores calcium accumulation, confirming that quercetin mechanism of action hinges on inhibition of the beta-catenin pathway.	Quercetin	174-183	glycogen synthase kinase 3 beta	Homo sapiens	69-99
23223575-5	2013	In the presence of quercetin, reactivation of beta-catenin using the glycogen synthase kinase-3beta (GSK-3beta) inhibitor LiCl restores calcium accumulation, confirming that quercetin mechanism of action hinges on inhibition of the beta-catenin pathway.	Quercetin	174-183	glycogen synthase kinase 3 beta	Homo sapiens	101-110
23223575-5	2013	In the presence of quercetin, reactivation of beta-catenin using the glycogen synthase kinase-3beta (GSK-3beta) inhibitor LiCl restores calcium accumulation, confirming that quercetin mechanism of action hinges on inhibition of the beta-catenin pathway.	Quercetin	174-183	catenin beta 1	Homo sapiens	232-244
23223575-8	2013	These results suggest a new beta-catenin-targeting strategy to prevent vascular calcification induced by warfarin and identify quercetin as a potential therapeutic in this pathology.	Quercetin	127-136	catenin beta 1	Homo sapiens	28-40
23143154-12	2013	Additionally, the expressions of PPARgamma, C/EBPalpha, and C/EBPbeta proteins were reduced in the quercetin-treated OFs.	Quercetin	99-108	peroxisome proliferator activated receptor gamma	Homo sapiens	33-42
23143154-12	2013	Additionally, the expressions of PPARgamma, C/EBPalpha, and C/EBPbeta proteins were reduced in the quercetin-treated OFs.	Quercetin	99-108	CCAAT enhancer binding protein alpha	Homo sapiens	44-54
23143154-12	2013	Additionally, the expressions of PPARgamma, C/EBPalpha, and C/EBPbeta proteins were reduced in the quercetin-treated OFs.	Quercetin	99-108	CCAAT enhancer binding protein beta	Homo sapiens	60-69
23143154-13	2013	Quercetin also reduced the CSE- and H(2)O(2)-induced upregulation of ROS and HO-1 protein in differentiated OFs and preadipocyte OFs.	Quercetin	0-9	heme oxygenase 1	Homo sapiens	77-81
24083712-6	2013	Viability of K562 cells was increased by low dose of quercetin (5-100 muM) for 3 hours.	Quercetin	53-62	latexin	Homo sapiens	70-73
23219797-5	2013	Male Sprague-Dawley rats untreated or treated with either YC-1 or quercetin (heat shock protein (Hsp) 70 inhibitor) were exposures to heat as a model of heat stroke.	Quercetin	66-75	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	77-104
23219797-12	2013	All of the protective effects of YC-1 were all significantly suppressed when pretreated with quercetin (400mg/kg).	Quercetin	93-102	glutathione S-transferase alpha 1	Rattus norvegicus	33-37
23085029-12	2013	These results indicate that quercetin has antioxidant effect and protects NO from endogenous superoxide anion-driven inactivation and enhances its biological activity, suggesting that quercetin may scavenge superoxide anion in a Cu/Zn SOD, glutathione or ascorbic acid-inhibitable manner.	Quercetin	28-37	superoxide dismutase 1, soluble	Mus musculus	229-238
23085029-12	2013	These results indicate that quercetin has antioxidant effect and protects NO from endogenous superoxide anion-driven inactivation and enhances its biological activity, suggesting that quercetin may scavenge superoxide anion in a Cu/Zn SOD, glutathione or ascorbic acid-inhibitable manner.	Quercetin	184-193	superoxide dismutase 1, soluble	Mus musculus	229-238
23117658-3	2013	These effects of warfarin can be completely reversed by intraperitoneal administration of the TG2-specific inhibitor KCC-009 or dietary supplementation with the bioflavonoid quercetin, known to inhibit beta-catenin signaling.	Quercetin	174-183	catenin beta 1	Rattus norvegicus	202-214
23117658-4	2013	Our study also uncovers a previously uncharacterized ability of quercetin to inhibit TG2.	Quercetin	64-73	transglutaminase 2	Rattus norvegicus	85-88
24083712-7	2013	High doses of quercetin proved toxic (100-500 muM, 24 hours) and resulted in decrease of K562 cell viability as expected (P&lt;0.01).	Quercetin	14-23	latexin	Homo sapiens	46-49
24083712-8	2013	As to results, 100 muM quercetin was defined as a protective dose.	Quercetin	23-32	latexin	Homo sapiens	19-22
23727915-6	2013	Further validation assays confirmed that quercetin inhibited growth by suppressing NF-kappaB and by increasing the expression of death receptors and cell cycle inhibitors.	Quercetin	41-50	nuclear factor kappa B subunit 1	Homo sapiens	83-92
23439570-0	2013	Quercetin but not quercitrin ameliorates tumor necrosis factor-alpha-induced insulin resistance in C2C12 skeletal muscle cells.	Quercetin	0-9	tumor necrosis factor	Mus musculus	41-68
23439570-3	2013	We aimed to investigate the role of quercetin and its glycoside, quercitrin in tumor necrosis factor-alpha (TNF-alpha) induced C2C12 skeletal muscle cell impairment.	Quercetin	36-45	tumor necrosis factor	Mus musculus	79-106
23439570-3	2013	We aimed to investigate the role of quercetin and its glycoside, quercitrin in tumor necrosis factor-alpha (TNF-alpha) induced C2C12 skeletal muscle cell impairment.	Quercetin	36-45	tumor necrosis factor	Mus musculus	108-117
23439570-4	2013	Quercetin, but not quercitrin moderately attenuated the effects of TNF-alpha and enhanced the basal and insulin stimulated uptake of glucose in a dose-dependent manner via the activation of the protein kinase B (Akt) and AMP-activated protein kinase (AMPK) pathways.	Quercetin	0-9	tumor necrosis factor	Mus musculus	67-76
23439570-4	2013	Quercetin, but not quercitrin moderately attenuated the effects of TNF-alpha and enhanced the basal and insulin stimulated uptake of glucose in a dose-dependent manner via the activation of the protein kinase B (Akt) and AMP-activated protein kinase (AMPK) pathways.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	212-215
23439570-6	2013	In summary, quercetin exhibited its effect of improving glucose uptake and insulin sensitivity in skeletal muscle cells via the two independent signaling pathways of Akt and AMPK, and can be developed as a potential anti-diabetic agent.	Quercetin	12-21	thymoma viral proto-oncogene 1	Mus musculus	166-169
24648896-0	2013	Quercetin improves insulin resistance and hepatic lipid accumulation in vitro in a NAFLD cell model.	Quercetin	0-9	insulin	Homo sapiens	19-26
23995665-6	2013	AKR1C5 was potently and competitively inhibited by flavonoids such as kaempferol and quercetin, suggesting that its activity is affected by ingested flavonoids.	Quercetin	85-94	prostaglandin-E(2) 9-reductase	Oryctolagus cuniculus	0-6
24648896-6	2013	These results demonstrated that quercetin was able to improve insulin resistance and hepatic lipid accumulation by suppressing two lipogenesis gene expression levels of SREBP-1c and FAS.	Quercetin	32-41	sterol regulatory element binding transcription factor 1	Homo sapiens	169-177
24648896-2	2013	The aim of this study was to investigate the effect of quercetin on insulin resistance and lipid metabolic abnormalities in free fatty acid (FFA)- and insulin-induced HepG2 cell model of NAFLD, and to determine the possible underlying mechanism.	Quercetin	55-64	insulin	Homo sapiens	68-75
24648896-6	2013	These results demonstrated that quercetin was able to improve insulin resistance and hepatic lipid accumulation by suppressing two lipogenesis gene expression levels of SREBP-1c and FAS.	Quercetin	32-41	fatty acid synthase	Homo sapiens	182-185
24648896-2	2013	The aim of this study was to investigate the effect of quercetin on insulin resistance and lipid metabolic abnormalities in free fatty acid (FFA)- and insulin-induced HepG2 cell model of NAFLD, and to determine the possible underlying mechanism.	Quercetin	55-64	insulin	Homo sapiens	151-158
24648896-5	2013	Quercetin was found to enhance tyrosine phosphorylation in the insulin-signaling pathway and to downregulate the expression levels of the sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) in quercetin-treated groups, compared to the control group.	Quercetin	0-9	insulin	Homo sapiens	63-70
24648896-5	2013	Quercetin was found to enhance tyrosine phosphorylation in the insulin-signaling pathway and to downregulate the expression levels of the sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) in quercetin-treated groups, compared to the control group.	Quercetin	0-9	sterol regulatory element binding transcription factor 1	Homo sapiens	138-182
24648896-5	2013	Quercetin was found to enhance tyrosine phosphorylation in the insulin-signaling pathway and to downregulate the expression levels of the sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) in quercetin-treated groups, compared to the control group.	Quercetin	0-9	sterol regulatory element binding transcription factor 1	Homo sapiens	184-192
24648896-5	2013	Quercetin was found to enhance tyrosine phosphorylation in the insulin-signaling pathway and to downregulate the expression levels of the sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) in quercetin-treated groups, compared to the control group.	Quercetin	0-9	fatty acid synthase	Homo sapiens	198-217
24648896-5	2013	Quercetin was found to enhance tyrosine phosphorylation in the insulin-signaling pathway and to downregulate the expression levels of the sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) in quercetin-treated groups, compared to the control group.	Quercetin	0-9	fatty acid synthase	Homo sapiens	219-222
24648896-5	2013	Quercetin was found to enhance tyrosine phosphorylation in the insulin-signaling pathway and to downregulate the expression levels of the sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) in quercetin-treated groups, compared to the control group.	Quercetin	227-236	sterol regulatory element binding transcription factor 1	Homo sapiens	138-182
24648896-5	2013	Quercetin was found to enhance tyrosine phosphorylation in the insulin-signaling pathway and to downregulate the expression levels of the sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) in quercetin-treated groups, compared to the control group.	Quercetin	227-236	sterol regulatory element binding transcription factor 1	Homo sapiens	184-192
24648896-5	2013	Quercetin was found to enhance tyrosine phosphorylation in the insulin-signaling pathway and to downregulate the expression levels of the sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) in quercetin-treated groups, compared to the control group.	Quercetin	227-236	fatty acid synthase	Homo sapiens	198-217
24648896-6	2013	These results demonstrated that quercetin was able to improve insulin resistance and hepatic lipid accumulation by suppressing two lipogenesis gene expression levels of SREBP-1c and FAS.	Quercetin	32-41	insulin	Homo sapiens	62-69
23365610-2	2013	Pretreatment with both H. inuloides extracts or quercetin attenuated the increase in serum activity of alkaline phosphatase (ALP), total bilirubin (BB), creatinine (CRE), and creatine kinase (CK), and impeded the decrease of gamma-globulin (gamma-GLOB) and albumin (ALB) observed in CCl(4)-induced tissue injury.	Quercetin	48-57	albumin	Rattus norvegicus	266-269
23840245-5	2013	The second part of the experiment was designed to examine the influence of quercetin on eosinophil activation induced by SCF stimulation in vitro.	Quercetin	75-84	kit ligand	Mus musculus	121-124
23840245-6	2013	Eosinophils were obtained from M. corti-infected mice and stimulated with SCF in the presence of various concentrations of quercetin for 24 h. The addition of quercetin into cell cultures could suppress eosinophil activation induced by SCF stimulation as assessed by measuring the contents of RANTES, MIP-1 beta , ECP, and MBP in culture supernatants.	Quercetin	159-168	kit ligand	Mus musculus	74-77
23840245-6	2013	Eosinophils were obtained from M. corti-infected mice and stimulated with SCF in the presence of various concentrations of quercetin for 24 h. The addition of quercetin into cell cultures could suppress eosinophil activation induced by SCF stimulation as assessed by measuring the contents of RANTES, MIP-1 beta , ECP, and MBP in culture supernatants.	Quercetin	159-168	kit ligand	Mus musculus	236-239
23840245-6	2013	Eosinophils were obtained from M. corti-infected mice and stimulated with SCF in the presence of various concentrations of quercetin for 24 h. The addition of quercetin into cell cultures could suppress eosinophil activation induced by SCF stimulation as assessed by measuring the contents of RANTES, MIP-1 beta , ECP, and MBP in culture supernatants.	Quercetin	159-168	chemokine (C-C motif) ligand 5	Mus musculus	293-299
23840245-6	2013	Eosinophils were obtained from M. corti-infected mice and stimulated with SCF in the presence of various concentrations of quercetin for 24 h. The addition of quercetin into cell cultures could suppress eosinophil activation induced by SCF stimulation as assessed by measuring the contents of RANTES, MIP-1 beta , ECP, and MBP in culture supernatants.	Quercetin	159-168	chemokine (C-C motif) ligand 4	Mus musculus	301-311
23533474-0	2013	Quercetin Preserves beta -Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
23533474-0	2013	Quercetin Preserves beta -Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation.	Quercetin	0-9	forkhead box O1	Rattus norvegicus	120-125
23533474-5	2013	High fructose increased forkhead box protein O1 (FoxO1) expressions in vivo and in vitro, which were reversed by quercetin.	Quercetin	113-122	forkhead box O1	Rattus norvegicus	24-47
23533474-5	2013	High fructose increased forkhead box protein O1 (FoxO1) expressions in vivo and in vitro, which were reversed by quercetin.	Quercetin	113-122	forkhead box O1	Rattus norvegicus	49-54
23533474-6	2013	Quercetin downregulated Akt and FoxO1 phosphorylation in fructose-fed rat islets and increased the nuclear FoxO1 levels in fructose-treated INS-1 beta -cells.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	24-27
23533474-6	2013	Quercetin downregulated Akt and FoxO1 phosphorylation in fructose-fed rat islets and increased the nuclear FoxO1 levels in fructose-treated INS-1 beta -cells.	Quercetin	0-9	forkhead box O1	Rattus norvegicus	32-37
23533474-6	2013	Quercetin downregulated Akt and FoxO1 phosphorylation in fructose-fed rat islets and increased the nuclear FoxO1 levels in fructose-treated INS-1 beta -cells.	Quercetin	0-9	forkhead box O1	Rattus norvegicus	107-112
23533474-7	2013	The elevated Akt phosphorylation in fructose-treated INS-1 beta -cells was also restored by quercetin.	Quercetin	92-101	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
23479759-11	2013	l-NAME or quercetin eliminated most of the beneficial effects of HBO on DCS, and counteracted the stimulation of HSP70 by HBO.	Quercetin	10-19	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	113-118
23017387-5	2013	Expression of quinone reductase, glutathione reductase and methionine sulfoxide reductase A proteins were significantly up-regulated by quercetin, suggesting their involvement in the cytoprotective activity of quercetin.	Quercetin	136-145	glutathione-disulfide reductase	Homo sapiens	33-54
23573126-3	2013	The cardioprotective effects of quercetin are achieved by reducing the activity of Src kinase, signal transducer and activator of transcription 3 (STAT3), caspase 9, Bax, intracellular reactive oxygen species production, and inflammatory factor and inducible MnSOD expression.	Quercetin	32-41	signal transducer and activator of transcription 3	Rattus norvegicus	95-145
23573126-3	2013	The cardioprotective effects of quercetin are achieved by reducing the activity of Src kinase, signal transducer and activator of transcription 3 (STAT3), caspase 9, Bax, intracellular reactive oxygen species production, and inflammatory factor and inducible MnSOD expression.	Quercetin	32-41	signal transducer and activator of transcription 3	Rattus norvegicus	147-152
23573126-3	2013	The cardioprotective effects of quercetin are achieved by reducing the activity of Src kinase, signal transducer and activator of transcription 3 (STAT3), caspase 9, Bax, intracellular reactive oxygen species production, and inflammatory factor and inducible MnSOD expression.	Quercetin	32-41	caspase 9	Rattus norvegicus	155-164
23573126-3	2013	The cardioprotective effects of quercetin are achieved by reducing the activity of Src kinase, signal transducer and activator of transcription 3 (STAT3), caspase 9, Bax, intracellular reactive oxygen species production, and inflammatory factor and inducible MnSOD expression.	Quercetin	32-41	BCL2 associated X, apoptosis regulator	Rattus norvegicus	166-169
23573126-3	2013	The cardioprotective effects of quercetin are achieved by reducing the activity of Src kinase, signal transducer and activator of transcription 3 (STAT3), caspase 9, Bax, intracellular reactive oxygen species production, and inflammatory factor and inducible MnSOD expression.	Quercetin	32-41	superoxide dismutase 2	Rattus norvegicus	259-264
23573126-6	2013	Quercetin dephosphorylates Src kinase in H2O2-induced H9C2 cells and likely blocks the H2O2-induced inflammatory response through STAT3 kinase modulation.	Quercetin	0-9	signal transducer and activator of transcription 3	Rattus norvegicus	130-135
23724859-3	2013	In vitro studies using Caco-2 cells have shown that some polyphenols (quercetin, genistein, resveratrol) may impair OTA efflux through competitive inhibition of MRP2, possibly resulting in an increased systemic availability of OTA.	Quercetin	70-79	ATP binding cassette subfamily C member 2	Homo sapiens	161-165
23533474-8	2013	Additionally, quercetin suppressed the expression of pancreatic and duodenal homeobox 1 (Pdx1) and insulin gene (Ins1 and Ins2) in vivo and in vitro.	Quercetin	14-23	pancreatic and duodenal homeobox 1	Rattus norvegicus	89-93
23533474-8	2013	Additionally, quercetin suppressed the expression of pancreatic and duodenal homeobox 1 (Pdx1) and insulin gene (Ins1 and Ins2) in vivo and in vitro.	Quercetin	14-23	insulin 1	Rattus norvegicus	113-117
23533474-8	2013	Additionally, quercetin suppressed the expression of pancreatic and duodenal homeobox 1 (Pdx1) and insulin gene (Ins1 and Ins2) in vivo and in vitro.	Quercetin	14-23	insulin 2	Rattus norvegicus	122-126
23533474-9	2013	In fructose-treated INS-1 beta -cells, quercetin elevated the reduced janus kinase 2/signal transducers and activators of transcription 3 (Jak2/Stat3) phosphorylation and suppressed the increased suppressor of cytokine signaling 3 (Socs3) expression.	Quercetin	39-48	Janus kinase 2	Rattus norvegicus	70-84
23533474-9	2013	In fructose-treated INS-1 beta -cells, quercetin elevated the reduced janus kinase 2/signal transducers and activators of transcription 3 (Jak2/Stat3) phosphorylation and suppressed the increased suppressor of cytokine signaling 3 (Socs3) expression.	Quercetin	39-48	Janus kinase 2	Rattus norvegicus	139-143
23533474-9	2013	In fructose-treated INS-1 beta -cells, quercetin elevated the reduced janus kinase 2/signal transducers and activators of transcription 3 (Jak2/Stat3) phosphorylation and suppressed the increased suppressor of cytokine signaling 3 (Socs3) expression.	Quercetin	39-48	signal transducer and activator of transcription 3	Rattus norvegicus	144-149
23533474-9	2013	In fructose-treated INS-1 beta -cells, quercetin elevated the reduced janus kinase 2/signal transducers and activators of transcription 3 (Jak2/Stat3) phosphorylation and suppressed the increased suppressor of cytokine signaling 3 (Socs3) expression.	Quercetin	39-48	suppressor of cytokine signaling 3	Rattus norvegicus	196-230
23533474-9	2013	In fructose-treated INS-1 beta -cells, quercetin elevated the reduced janus kinase 2/signal transducers and activators of transcription 3 (Jak2/Stat3) phosphorylation and suppressed the increased suppressor of cytokine signaling 3 (Socs3) expression.	Quercetin	39-48	suppressor of cytokine signaling 3	Rattus norvegicus	232-237
23533474-10	2013	These results demonstrate that quercetin protects beta -cell mass and function under high-fructose induction through improving leptin signaling and preserving pancreatic Akt/FoxO1 activation.	Quercetin	31-40	forkhead box O1	Rattus norvegicus	174-179
23172078-3	2013	The maximum amount of soluble quercetin that could be loaded into a carrier oil phase (medium chain triglycerides, MCT) at ambient temperature was C(Sat)  0.15 mg mL(-1).	Quercetin	30-39	solute carrier family 16 member 1	Homo sapiens	115-118
23017387-5	2013	Expression of quinone reductase, glutathione reductase and methionine sulfoxide reductase A proteins were significantly up-regulated by quercetin, suggesting their involvement in the cytoprotective activity of quercetin.	Quercetin	210-219	glutathione-disulfide reductase	Homo sapiens	33-54
23132664-3	2013	Eight major flavonoids (naringin, naringenin, hesperidin, hesperetin, phloridzin, phloretin, quercetin, and kaempferol) contained in the juices inhibited OATP2B1-mediated estrone-3-sulfate uptake with IC(50) values of 4.63, 49.2, 1.92, 67.6, 23.2, 1.31, 9.47, and 21.3 microM, respectively.	Quercetin	93-102	solute carrier organic anion transporter family member 2B1 L homeolog	Xenopus laevis	154-161
24324490-8	2013	Pretreatment with quercetin and Gelam honey extract improved insulin resistance and insulin content by reducing the expression of MAPK, NF- kappa B, and IRS-1 serine phosphorylation (ser307) and increasing the expression of Akt significantly.	Quercetin	18-27	insulin	Mesocricetus auratus	61-68
24324490-8	2013	Pretreatment with quercetin and Gelam honey extract improved insulin resistance and insulin content by reducing the expression of MAPK, NF- kappa B, and IRS-1 serine phosphorylation (ser307) and increasing the expression of Akt significantly.	Quercetin	18-27	insulin	Mesocricetus auratus	84-91
24324490-8	2013	Pretreatment with quercetin and Gelam honey extract improved insulin resistance and insulin content by reducing the expression of MAPK, NF- kappa B, and IRS-1 serine phosphorylation (ser307) and increasing the expression of Akt significantly.	Quercetin	18-27	insulin receptor substrate 1	Mesocricetus auratus	153-158
23132664-6	2013	However, significant inhibition of OATP2B1 was observed with a mixture of phloridzin, phloretin, hesperidin, and quercetin at the concentrations present in AJ.	Quercetin	113-122	solute carrier organic anion transporter family member 2B1 L homeolog	Xenopus laevis	35-42
22595451-6	2013	RESULTS: In the atherosclerotic progression study, quercetin coadministered with the HCD significantly decreased the activities of inflammatory enzymes such as cyclooxygenase, lipoxygenases (LOX) such as 5-LOX and 12-LOX in monocytes, nitric oxide synthase activity in the plasma, myeloperoxidase activity in the aorta, and the level of C-reactive protein in serum.	Quercetin	51-60	arachidonate 12-lipoxygenase, 12S-type	Oryctolagus cuniculus	214-220
23530649-0	2013	Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a.	Quercetin	16-25	microRNA 27a	Homo sapiens	110-122
24032376-5	2013	Quercetin alone, or in combination with IR, increased the cleavage of caspase-3 and PARP-1 showing an activated apoptosis and significantly reduced the level of phospho-Akt.	Quercetin	0-9	caspase 3	Homo sapiens	70-79
24032376-5	2013	Quercetin alone, or in combination with IR, increased the cleavage of caspase-3 and PARP-1 showing an activated apoptosis and significantly reduced the level of phospho-Akt.	Quercetin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	84-90
24032376-7	2013	Our data indicate that the supplementation of standard therapy with quercetin increases efficacy of treatment of experimental glioblastoma through synergism in the induction of apoptosis via the cleavage of caspase-3 and PARP-1 and by the suppression of the actitivation of Akt pathway.	Quercetin	68-77	caspase 3	Homo sapiens	207-216
22595451-6	2013	RESULTS: In the atherosclerotic progression study, quercetin coadministered with the HCD significantly decreased the activities of inflammatory enzymes such as cyclooxygenase, lipoxygenases (LOX) such as 5-LOX and 12-LOX in monocytes, nitric oxide synthase activity in the plasma, myeloperoxidase activity in the aorta, and the level of C-reactive protein in serum.	Quercetin	51-60	myeloperoxidase	Oryctolagus cuniculus	281-296
24032376-7	2013	Our data indicate that the supplementation of standard therapy with quercetin increases efficacy of treatment of experimental glioblastoma through synergism in the induction of apoptosis via the cleavage of caspase-3 and PARP-1 and by the suppression of the actitivation of Akt pathway.	Quercetin	68-77	poly(ADP-ribose) polymerase 1	Homo sapiens	221-227
23359794-11	2013	Two relevant regulators, cytochrome P450 oxidoreductase (Por, rate limiting for cytochrome P450s) and the transcription factor constitutive androstane receptor (Car; official symbol Nr1i3) were also up-regulated in the quercetin-fed mice.	Quercetin	219-228	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	25-40
24288584-5	2013	We found that quercetin treatment induced expression of mitochondrial biogenesis activators (PGC-1 alpha , NRF-1, TFAM), mitochondrial DNA (mtDNA), and proteins (COX IV) in HepG2 cells.	Quercetin	14-23	PPARG coactivator 1 alpha	Homo sapiens	93-104
24288584-5	2013	We found that quercetin treatment induced expression of mitochondrial biogenesis activators (PGC-1 alpha , NRF-1, TFAM), mitochondrial DNA (mtDNA), and proteins (COX IV) in HepG2 cells.	Quercetin	14-23	nuclear respiratory factor 1	Homo sapiens	107-112
24288584-5	2013	We found that quercetin treatment induced expression of mitochondrial biogenesis activators (PGC-1 alpha , NRF-1, TFAM), mitochondrial DNA (mtDNA), and proteins (COX IV) in HepG2 cells.	Quercetin	14-23	transcription factor A, mitochondrial	Homo sapiens	114-118
24288584-5	2013	We found that quercetin treatment induced expression of mitochondrial biogenesis activators (PGC-1 alpha , NRF-1, TFAM), mitochondrial DNA (mtDNA), and proteins (COX IV) in HepG2 cells.	Quercetin	14-23	cytochrome c oxidase subunit 4I1	Homo sapiens	162-168
24288584-10	2013	Thus, our results suggest that quercetin enhances mitochondrial biogenesis mainly via the HO-1/CO system in vitro and in vivo.	Quercetin	31-40	heme oxygenase 1	Homo sapiens	90-97
23661994-9	2013	CONCLUSION: Our in silico study has explored the possible chemopreventive mechanism of these phytochemicals against the NF-kappaB precursor protein p105 and deciphered that quercetin, 1-caffeoylquinic acid and guggulsterone were the potent inhibitors against target molecule.	Quercetin	173-182	nuclear factor kappa B subunit 1	Homo sapiens	120-129
23342112-0	2013	Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo.	Quercetin	0-9	tumor protein p53	Homo sapiens	84-87
23342112-2	2013	We first showed that quercetin (5 microM) significantly increased the growth arrest and apoptosis in A549 cells (expressing wild-type p53) induced by 25 ng/mL of (82.5 nM) TSA at 48 h by about 25% and 101%, respectively.	Quercetin	21-30	tumor protein p53	Homo sapiens	134-137
23342112-4	2013	In addition, quercetin significantly increased TSA-induced p53 expression in A549 cells.	Quercetin	13-22	tumor protein p53	Homo sapiens	59-62
23342112-7	2013	Transfection of p53 siRNA abolished such enhancing effects of quercetin.	Quercetin	62-71	tumor protein p53	Homo sapiens	16-19
23342112-8	2013	However, quercetin increased the acetylation of histones H3 and H4 induced by TSA in A549 cells, even with p53 siRNA transfection as well as in H1299 cells.	Quercetin	9-18	tumor protein p53	Homo sapiens	107-110
23342112-10	2013	Tumors from mice treated with TSA in combination with quercetin had higher p53 and apoptosis levels than did those from control and TSA-treated mice.	Quercetin	54-63	transformation related protein 53, pseudogene	Mus musculus	75-78
23342112-11	2013	These data indicate that regulation of the expression of p53 by quercetin plays an important role in enhancing TSA-induced apoptosis in A549 cells.	Quercetin	64-73	tumor protein p53	Homo sapiens	57-60
23342112-12	2013	However, p53-independent mechanisms may also contribute to the enhancing effect of quercetin.	Quercetin	83-92	tumor protein p53	Homo sapiens	9-12
22595451-7	2013	In the regression study, quercetin administration significantly decreased the increased activities of inflammatory mediators such as cyclooxygenase, 5-LOX, 12-LOX, myeloperoxidase, and nitric oxide synthase and the serum level of C-reactive protein in HCD-fed rabbits compared with regression control rabbits.	Quercetin	25-34	arachidonate 12-lipoxygenase, 12S-type	Oryctolagus cuniculus	156-162
22595451-7	2013	In the regression study, quercetin administration significantly decreased the increased activities of inflammatory mediators such as cyclooxygenase, 5-LOX, 12-LOX, myeloperoxidase, and nitric oxide synthase and the serum level of C-reactive protein in HCD-fed rabbits compared with regression control rabbits.	Quercetin	25-34	myeloperoxidase	Oryctolagus cuniculus	164-179
24379902-2	2013	However, U373MG malignant glioma cells expressing mutant p53 are resistant to a 24 h quercetin treatment.	Quercetin	85-94	tumor protein p53	Homo sapiens	57-60
24379902-4	2013	Quercetin induced U373MG cell death through apoptosis, as evidenced by the increased number of cells in the sub-G1 phase, the appearance of fragmented nuclei, decreased mitochondrial membrane potential, proteolytic activation of caspase-3 and caspase-7, an increase in caspase-3 and 9 activities, and degradation of poly(ADP-ribose) polymerase protein.	Quercetin	0-9	caspase 3	Homo sapiens	229-238
24379902-4	2013	Quercetin induced U373MG cell death through apoptosis, as evidenced by the increased number of cells in the sub-G1 phase, the appearance of fragmented nuclei, decreased mitochondrial membrane potential, proteolytic activation of caspase-3 and caspase-7, an increase in caspase-3 and 9 activities, and degradation of poly(ADP-ribose) polymerase protein.	Quercetin	0-9	caspase 7	Homo sapiens	243-252
24379902-4	2013	Quercetin induced U373MG cell death through apoptosis, as evidenced by the increased number of cells in the sub-G1 phase, the appearance of fragmented nuclei, decreased mitochondrial membrane potential, proteolytic activation of caspase-3 and caspase-7, an increase in caspase-3 and 9 activities, and degradation of poly(ADP-ribose) polymerase protein.	Quercetin	0-9	caspase 3	Homo sapiens	269-278
24379902-5	2013	Furthermore, quercetin activated JNK and increased the expression of p53, which translocated to the mitochondria and simultaneously led to the release of cytochrome c from mitochondria to the cytosol.	Quercetin	13-22	mitogen-activated protein kinase 8	Homo sapiens	33-36
24379902-5	2013	Furthermore, quercetin activated JNK and increased the expression of p53, which translocated to the mitochondria and simultaneously led to the release of cytochrome c from mitochondria to the cytosol.	Quercetin	13-22	tumor protein p53	Homo sapiens	69-72
24379902-5	2013	Furthermore, quercetin activated JNK and increased the expression of p53, which translocated to the mitochondria and simultaneously led to the release of cytochrome c from mitochondria to the cytosol.	Quercetin	13-22	cytochrome c, somatic	Homo sapiens	154-166
23249183-6	2013	Both Que and DiOHF showed inhibition of collagen, adenosine diphosphate and arachidonic acid stimulated platelet aggregation, agonist-induced GPIIb/IIIa activation as demonstrated by PAC-1 and fibrinogen binding.	Quercetin	5-8	integrin alpha 2b	Mus musculus	142-147
23249183-6	2013	Both Que and DiOHF showed inhibition of collagen, adenosine diphosphate and arachidonic acid stimulated platelet aggregation, agonist-induced GPIIb/IIIa activation as demonstrated by PAC-1 and fibrinogen binding.	Quercetin	5-8	dual specificity phosphatase 2	Mus musculus	183-188
23359794-11	2013	Two relevant regulators, cytochrome P450 oxidoreductase (Por, rate limiting for cytochrome P450s) and the transcription factor constitutive androstane receptor (Car; official symbol Nr1i3) were also up-regulated in the quercetin-fed mice.	Quercetin	219-228	nuclear receptor subfamily 1, group I, member 3	Mus musculus	127-159
23359794-11	2013	Two relevant regulators, cytochrome P450 oxidoreductase (Por, rate limiting for cytochrome P450s) and the transcription factor constitutive androstane receptor (Car; official symbol Nr1i3) were also up-regulated in the quercetin-fed mice.	Quercetin	219-228	nuclear receptor subfamily 1, group I, member 3	Mus musculus	182-187
23273205-4	2012	In vitro treatment with quercetin caused inhibition of both Na(+)/K(+) ATPase and NHE.	Quercetin	24-33	solute carrier family 9 member C1	Homo sapiens	82-85
23663767-0	2013	[Effects of quercetin on serum levels of resistin and IL-18 and on insulin resistance in nonalcoholic fatty liver disease rats].	Quercetin	12-21	interleukin 18	Rattus norvegicus	54-59
23663767-1	2013	OBJECTIVE: To investigate the effects of quercetin on serum levels of resistin and interleukin (IL)-18 and incidence of insulin resistance (IR) in nonalcoholic fatty liver disease (NAFLD) using a rat model.	Quercetin	41-50	interleukin 18	Rattus norvegicus	83-102
23663767-7	2013	RESULTS: Compared to the untreated model rats, the quercetin treated model rats showed significantly lower serum resistin (5.98 vs. 2.70), serum IL-18 (10.93 vs. 8.21), FPG (7.45 vs. 4.99), FINS (12.69 vs. 8.59), and HOMA-IR (4.22 vs. 1.87) (all P less than 0.01).	Quercetin	51-60	interleukin 18	Rattus norvegicus	145-150
24396596-7	2013	Moreover, activity of the collagenase MMP-7, which was high in fibrotic tissue, was seen restored after quercetin administration.	Quercetin	104-113	matrix metallopeptidase 7	Rattus norvegicus	38-43
23596717-0	2013	[Effect of quercetin on the expression of TGF-beta1 in human embryonic lung fibroblasts activated by the silicotic alveolar macrophages].	Quercetin	11-20	transforming growth factor beta 1	Homo sapiens	42-51
23273205-6	2012	The effect of quercetin on Na(+)/K(+) ATPase and NHE may be explained due to a direct effect of this compound on plasma membrane leading to a change in membrane fluidity.	Quercetin	14-23	solute carrier family 9 member C1	Homo sapiens	49-52
22349996-17	2012	CONCLUSION: The present investigation elucidates neuroprotective effect of quercetin in alcohol induced neuropathy through modulation of membrane-bound inorganic phosphate enzyme and inhibition of release of oxido-inflammatory mediators, such as MDA, MPO and NO.	Quercetin	75-84	myeloperoxidase	Rattus norvegicus	251-254
23540163-8	2012	After the treatment of UUO rats with quercetin, approximately 69%, 32%, 65%, 35% and 41% of the volume of the glomeruli, proximal and distal convoluted tubules (PCT and DCT), Henle"s loop and collecting ducts remained intact, respectively (p &lt; 0.01).	Quercetin	37-46	dopachrome tautomerase	Rattus norvegicus	169-172
23540163-10	2012	After the treatment of UUO rats with quercetin, approximately 71%, 81%, 51%, and 57% of the length of the PCT, DCT, Henle"s loop and collecting ducts remained intact, respectively (p &lt; 0.01).	Quercetin	37-46	dopachrome tautomerase	Rattus norvegicus	111-114
23393906-9	2012	Quercetin also exhibited the highest inhibitory effect on TNF-alpha production (IC50 = 1.25 microg/ml or 4.14 microM), but engeletin and astilbin had no activity.	Quercetin	0-9	tumor necrosis factor	Mus musculus	58-67
23064111-5	2012	Lipid peroxidation was decreased in samples treated with 30 muM quercetin (P&lt;0.01) and 30 muM rutin (P&lt;0.05) versus samples incubated with tert-butylhydroperoxide alone.	Quercetin	64-73	latexin	Homo sapiens	60-63
23281070-5	2012	Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor-1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase-9, caspase-3) and upregulating the antiapoptotic protein (Bcl-2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology.	Quercetin	36-45	aryl hydrocarbon receptor	Rattus norvegicus	168-193
23281070-5	2012	Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor-1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase-9, caspase-3) and upregulating the antiapoptotic protein (Bcl-2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology.	Quercetin	36-45	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	195-198
23281070-5	2012	Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor-1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase-9, caspase-3) and upregulating the antiapoptotic protein (Bcl-2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology.	Quercetin	36-45	BCL2 associated X, apoptosis regulator	Rattus norvegicus	222-225
23281070-5	2012	Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor-1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase-9, caspase-3) and upregulating the antiapoptotic protein (Bcl-2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology.	Quercetin	36-45	caspase 9	Rattus norvegicus	227-236
23281070-5	2012	Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor-1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase-9, caspase-3) and upregulating the antiapoptotic protein (Bcl-2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology.	Quercetin	36-45	caspase 3	Rattus norvegicus	238-247
23281070-5	2012	Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor-1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase-9, caspase-3) and upregulating the antiapoptotic protein (Bcl-2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology.	Quercetin	36-45	BCL2, apoptosis regulator	Rattus norvegicus	293-298
22936120-0	2012	Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway.	Quercetin	0-9	brain-derived neurotrophic factor	Rattus norvegicus	91-95
22936120-0	2012	Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway.	Quercetin	0-9	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	96-100
22936120-3	2012	It is not clear whether BDNF-TrkB-PI3K/Akt signaling pathway mediates the neuroprotection of quercetin, though there has been some reports on the quercetin increased brain-derived neurotrophic factor (BDNF) level in brain injury models.	Quercetin	146-155	brain-derived neurotrophic factor	Rattus norvegicus	166-199
22936120-3	2012	It is not clear whether BDNF-TrkB-PI3K/Akt signaling pathway mediates the neuroprotection of quercetin, though there has been some reports on the quercetin increased brain-derived neurotrophic factor (BDNF) level in brain injury models.	Quercetin	146-155	brain-derived neurotrophic factor	Rattus norvegicus	201-205
22936120-7	2012	The protein expression of BDNF, TrkB and p-Akt also increased in the quercetin treated rats.	Quercetin	69-78	brain-derived neurotrophic factor	Rattus norvegicus	26-30
22936120-7	2012	The protein expression of BDNF, TrkB and p-Akt also increased in the quercetin treated rats.	Quercetin	69-78	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	32-36
22936120-8	2012	However, treatment with LY294002 or K252a reversed the quercetin-induced increase of BDNF and p-Akt proteins and decrease of cleaved caspase-3 protein in focal cerebral ischemia rats.	Quercetin	55-64	brain-derived neurotrophic factor	Rattus norvegicus	85-89
22936120-9	2012	These results demonstrate that quercetin can decrease cell apoptosis in the focal cerebral ischemia rat brain and the mechanism may be related to the activation of BDNF-TrkB-PI3K/Akt signaling pathway.	Quercetin	31-40	brain-derived neurotrophic factor	Rattus norvegicus	164-168
22936120-9	2012	These results demonstrate that quercetin can decrease cell apoptosis in the focal cerebral ischemia rat brain and the mechanism may be related to the activation of BDNF-TrkB-PI3K/Akt signaling pathway.	Quercetin	31-40	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	169-173
22989100-2	2012	On the other hand, quercetin, a natural flavonoid is a potent antioxidant and activator of superoxide dismutase and catalase.	Quercetin	19-28	catalase	Rattus norvegicus	116-124
22989100-10	2012	Quercetin increased gene expression and functional activity of antioxidant enzymes superoxide dismutase and catalase.	Quercetin	0-9	catalase	Rattus norvegicus	108-116
22989100-13	2012	Quercetin also induced activation of matrix metalloproteinases MMP2 and MMP9 contributing to decreased index of fibrosis.	Quercetin	0-9	matrix metallopeptidase 2	Rattus norvegicus	63-67
22989100-13	2012	Quercetin also induced activation of matrix metalloproteinases MMP2 and MMP9 contributing to decreased index of fibrosis.	Quercetin	0-9	matrix metallopeptidase 9	Rattus norvegicus	72-76
22989100-14	2012	CONCLUSIONS: Treatment with quercetin reduces oxidation and inflammation and also prevents liver fibrosis, through induction of HSC apoptosis and activation of MMPs.	Quercetin	28-37	matrix metallopeptidase 2	Rattus norvegicus	160-164
23053990-5	2012	Quercetin treatment also attenuated the expression of both TNF-alpha (TNF-alpha) and interleukin-10 (IL-10) and lowered the serum levels of inflammatory cytokine (P &lt; 0.05).	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	59-68
23053990-5	2012	Quercetin treatment also attenuated the expression of both TNF-alpha (TNF-alpha) and interleukin-10 (IL-10) and lowered the serum levels of inflammatory cytokine (P &lt; 0.05).	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	70-79
23053990-5	2012	Quercetin treatment also attenuated the expression of both TNF-alpha (TNF-alpha) and interleukin-10 (IL-10) and lowered the serum levels of inflammatory cytokine (P &lt; 0.05).	Quercetin	0-9	interleukin 10	Rattus norvegicus	85-99
23053990-5	2012	Quercetin treatment also attenuated the expression of both TNF-alpha (TNF-alpha) and interleukin-10 (IL-10) and lowered the serum levels of inflammatory cytokine (P &lt; 0.05).	Quercetin	0-9	interleukin 10	Rattus norvegicus	101-106
23073654-3	2012	The aim of our study was to investigate the effects of quercetin (up to 150 muM), the ubiquitous plant-derived flavonoid and highly potent scavenger of reactive oxygen species (ROS) on healthy P19 neurons, in order to assess the efficacy and safety of its long-term use in neurodegenerative prevention.	Quercetin	55-64	interleukin 23 subunit alpha	Homo sapiens	193-196
23556141-5	2012	The present work focuses on the molecular docking analysis of quercetin and its analogues against iNOS enzyme.	Quercetin	62-71	nitric oxide synthase 2	Homo sapiens	98-102
23556141-6	2012	Earlier there are reports of quercetin inhibiting iNOS enzyme in certain experiments as anti cancer agent.	Quercetin	29-38	nitric oxide synthase 2	Homo sapiens	50-54
23044718-8	2012	Quercetin treatment induced the apoptosis of A2780S cells associated with activating caspase-3 and caspase-9.	Quercetin	0-9	caspase 3	Homo sapiens	85-94
22975673-8	2012	Moreover, quercetin differentially inhibited HSP70 induction compared to catechin and naringenin.	Quercetin	10-19	heat shock protein family A (Hsp70) member 4	Homo sapiens	45-50
22335484-3	2012	The present study was aimed at examining the acrosin activity variations in LPC-induced acrosome exocytosis and its regulation by tyrosine kinase, protein kinase C (PKC) and voltage-dependent calcium channels (VDCC) in spermatozoa previously capacitated with heparin or quercetin.	Quercetin	270-279	acrosin	Bos taurus	45-52
23044718-8	2012	Quercetin treatment induced the apoptosis of A2780S cells associated with activating caspase-3 and caspase-9.	Quercetin	0-9	caspase 9	Homo sapiens	99-108
23044718-9	2012	MCL-1 downregulation, Bcl-2 downregulation, Bax upregulation and mitochondrial transmembrane potential change were observed, suggesting that quercetin may induce apoptosis of A2780S cells through the mitochondrial apoptotic pathway.	Quercetin	141-150	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	0-5
23044718-9	2012	MCL-1 downregulation, Bcl-2 downregulation, Bax upregulation and mitochondrial transmembrane potential change were observed, suggesting that quercetin may induce apoptosis of A2780S cells through the mitochondrial apoptotic pathway.	Quercetin	141-150	BCL2 associated X, apoptosis regulator	Homo sapiens	44-47
23044718-10	2012	Otherwise, quercetin treatment decreased phosphorylated p44/42 mitogen-activated protein kinase and phosphorylated Akt, contributing to inhibition of A2780S cell proliferation.	Quercetin	11-20	interferon induced protein 44	Homo sapiens	56-59
23044718-10	2012	Otherwise, quercetin treatment decreased phosphorylated p44/42 mitogen-activated protein kinase and phosphorylated Akt, contributing to inhibition of A2780S cell proliferation.	Quercetin	11-20	AKT serine/threonine kinase 1	Homo sapiens	115-118
22422552-1	2012	The natural flavonoid quercetin is a low affinity ligand of the aryl hydrocarbon receptor (AhR), a transcription factor regulating the expression of cytochrome P450 (CYP) 1A enzymes.	Quercetin	22-31	aryl hydrocarbon receptor	Homo sapiens	64-89
22869926-7	2012	In oxLDL-stimulated macrophages, quercetin inhibited reactive oxygen species production and interleukin (IL)-6 secretion.	Quercetin	33-42	interleukin 6	Mus musculus	92-110
22869926-8	2012	In a system that evaluated cholesterol crystal-induced IL-1beta secretion via nucleotide-binding domain and leucine-rich repeat containing protein 3 inflammasome activation, quercetin also exhibited an inhibitory effect.	Quercetin	174-183	interleukin 1 beta	Mus musculus	55-63
22388943-0	2012	Quercetin up-regulates LDL receptor expression in HepG2 cells.	Quercetin	0-9	low density lipoprotein receptor	Homo sapiens	23-35
22968713-0	2012	Decavanadate, decaniobate, tungstate and molybdate interactions with sarcoplasmic reticulum Ca(2+)-ATPase: quercetin prevents cysteine oxidation by vanadate but does not reverse ATPase inhibition.	Quercetin	107-116	dynein axonemal heavy chain 8	Homo sapiens	99-105
22992727-3	2012	In this study, we investigated the potential effects of isorhamnetin (IH), a 3"-O-methylated metabolite of quercetin on the peroxisome proliferator-activated receptor gamma (PPAR-gamma) signaling cascade using proteomics technology platform, GC cell lines, and xenograft mice model.	Quercetin	107-116	peroxisome proliferator activated receptor gamma	Mus musculus	174-184
23350198-3	2012	If the cells were treated with 17AAG or radicicol along with an inhibitor of the HSP induction (e.g. quercetin or triptolid, or NZ28), this fully prevented the increase in intracellular chaperone levels resulting from the inhibition of HSP90 activity and subsequent heating.	Quercetin	101-110	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	81-84
23350198-3	2012	If the cells were treated with 17AAG or radicicol along with an inhibitor of the HSP induction (e.g. quercetin or triptolid, or NZ28), this fully prevented the increase in intracellular chaperone levels resulting from the inhibition of HSP90 activity and subsequent heating.	Quercetin	101-110	heat shock protein 90 alpha family class A member 1	Homo sapiens	236-241
22221676-0	2012	Effects of physiological quercetin metabolites on interleukin-1beta-induced inducible NOS expression.	Quercetin	25-34	interleukin 1 beta	Rattus norvegicus	50-67
22221676-4	2012	Therefore, we investigated the effects of quercetin and its metabolites quercetin 3"-sulfate, quercetin 3-glucuronide and isorhamnetin 3-glucuronide on IL-1beta-stimulated iNOS gene expression in RINm5F beta-cells.	Quercetin	42-51	interleukin 1 beta	Rattus norvegicus	152-160
22221676-8	2012	Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	32-40
22221676-8	2012	Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity.	Quercetin	0-9	nitric oxide synthase 2	Rattus norvegicus	69-73
22221676-8	2012	Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	136-144
22221676-8	2012	Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity.	Quercetin	0-9	NFKB inhibitor alpha	Rattus norvegicus	153-165
22221676-8	2012	Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity.	Quercetin	0-9	nitric oxide synthase 2	Rattus norvegicus	208-212
22221676-9	2012	Additionally, quercetin significantly restored the inhibition of insulin secretion by IL-1beta.	Quercetin	14-23	interleukin 1 beta	Rattus norvegicus	86-94
22858203-3	2012	We examined the effect of parental exposure to a diet high in saturated fats and fructose 1 mo before conception through lactation on in vitro hepatic uridine 5"-diphosphate (UDP)-glucuronosyltransferase (UGT) activity toward quercetin in parent and offspring rats and the interaction between diet and sex.	Quercetin	226-235	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	151-203
22388943-2	2012	Here we investigated whether quercetin could modulate the expression of LDL receptors (LDLR) in HepG2 cells and the possible underlying mechanisms to exert quercetin"s effects.	Quercetin	29-38	low density lipoprotein receptor	Homo sapiens	87-91
22388943-3	2012	We found that quercetin was able to induce LDLR expression with at least a 75 micro m concentration, which was accompanied by an increase in nuclear sterol regulatory element binding protein 2 (SREBP2).	Quercetin	14-23	low density lipoprotein receptor	Homo sapiens	43-47
22388943-3	2012	We found that quercetin was able to induce LDLR expression with at least a 75 micro m concentration, which was accompanied by an increase in nuclear sterol regulatory element binding protein 2 (SREBP2).	Quercetin	14-23	sterol regulatory element binding transcription factor 2	Homo sapiens	149-192
22388943-3	2012	We found that quercetin was able to induce LDLR expression with at least a 75 micro m concentration, which was accompanied by an increase in nuclear sterol regulatory element binding protein 2 (SREBP2).	Quercetin	14-23	sterol regulatory element binding transcription factor 2	Homo sapiens	194-200
22388943-5	2012	When cells were challenged with protein synthesis inhibitors in quercetin-activated LDLR transcription, LDL mRNA levels were not significantly affected by cycloheximide but puromycin abolished quercetin-induced LDLR transcription.	Quercetin	64-73	low density lipoprotein receptor	Homo sapiens	84-88
22388943-5	2012	When cells were challenged with protein synthesis inhibitors in quercetin-activated LDLR transcription, LDL mRNA levels were not significantly affected by cycloheximide but puromycin abolished quercetin-induced LDLR transcription.	Quercetin	64-73	low density lipoprotein receptor	Homo sapiens	211-215
22388943-2	2012	Here we investigated whether quercetin could modulate the expression of LDL receptors (LDLR) in HepG2 cells and the possible underlying mechanisms to exert quercetin"s effects.	Quercetin	29-38	low density lipoprotein receptor	Homo sapiens	72-85
22422552-1	2012	The natural flavonoid quercetin is a low affinity ligand of the aryl hydrocarbon receptor (AhR), a transcription factor regulating the expression of cytochrome P450 (CYP) 1A enzymes.	Quercetin	22-31	aryl hydrocarbon receptor	Homo sapiens	91-94
22388943-5	2012	When cells were challenged with protein synthesis inhibitors in quercetin-activated LDLR transcription, LDL mRNA levels were not significantly affected by cycloheximide but puromycin abolished quercetin-induced LDLR transcription.	Quercetin	193-202	low density lipoprotein receptor	Homo sapiens	84-88
22388943-5	2012	When cells were challenged with protein synthesis inhibitors in quercetin-activated LDLR transcription, LDL mRNA levels were not significantly affected by cycloheximide but puromycin abolished quercetin-induced LDLR transcription.	Quercetin	193-202	low density lipoprotein receptor	Homo sapiens	211-215
22388943-6	2012	Taken together, we conclude that quercetin can initiate LDLR transcription by enhancing SREBP2 processing, but new protein synthesis might be necessary to exert a maximum effect of quercetin in the up-regulation of the LDLR gene.	Quercetin	33-42	low density lipoprotein receptor	Homo sapiens	56-60
22388943-6	2012	Taken together, we conclude that quercetin can initiate LDLR transcription by enhancing SREBP2 processing, but new protein synthesis might be necessary to exert a maximum effect of quercetin in the up-regulation of the LDLR gene.	Quercetin	33-42	sterol regulatory element binding transcription factor 2	Homo sapiens	88-94
22388943-6	2012	Taken together, we conclude that quercetin can initiate LDLR transcription by enhancing SREBP2 processing, but new protein synthesis might be necessary to exert a maximum effect of quercetin in the up-regulation of the LDLR gene.	Quercetin	181-190	low density lipoprotein receptor	Homo sapiens	219-223
22388943-7	2012	Our findings demonstrate that quercetin strongly up-regulated LDLR gene expression, which might elicit hypolipidemic effects by increasing the clearance of circulating LDL cholesterol levels from the blood.	Quercetin	30-39	low density lipoprotein receptor	Homo sapiens	62-66
22422552-0	2012	Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells.	Quercetin	0-9	aryl hydrocarbon receptor	Homo sapiens	80-83
22422552-3	2012	Gene reporter assays showed that quercetin significantly activated AhR and triggered CYP1A1 transcription after 24 h exposure.	Quercetin	33-42	aryl hydrocarbon receptor	Homo sapiens	67-70
22422552-0	2012	Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	99-105
22422552-3	2012	Gene reporter assays showed that quercetin significantly activated AhR and triggered CYP1A1 transcription after 24 h exposure.	Quercetin	33-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	85-91
22422552-5	2012	Quercetin also induced a significant increase in CYP1A1 mRNA levels together with a moderate increase in the level of CYP1A1 activity.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-55
22422552-5	2012	Quercetin also induced a significant increase in CYP1A1 mRNA levels together with a moderate increase in the level of CYP1A1 activity.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-124
22422552-9	2012	It is concluded that quercetin, but not its 3-O-glycosides isoquercitrin and rutin, induces AhR activation and CYP1A1 expression in HepG2 cells and that the CYP1A1-inducing activity of taxifolin has a low toxicological potential.	Quercetin	21-30	aryl hydrocarbon receptor	Homo sapiens	92-95
22422552-9	2012	It is concluded that quercetin, but not its 3-O-glycosides isoquercitrin and rutin, induces AhR activation and CYP1A1 expression in HepG2 cells and that the CYP1A1-inducing activity of taxifolin has a low toxicological potential.	Quercetin	21-30	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	111-117
22422552-9	2012	It is concluded that quercetin, but not its 3-O-glycosides isoquercitrin and rutin, induces AhR activation and CYP1A1 expression in HepG2 cells and that the CYP1A1-inducing activity of taxifolin has a low toxicological potential.	Quercetin	21-30	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	157-163
22902988-7	2012	Quercetin prevented the decrease in Cu/Zn SOD activity in CCl(4)-intoxicated mice more potently than rutin.	Quercetin	0-9	superoxide dismutase 1, soluble	Mus musculus	36-45
23236317-11	2012	Quercetin suppressed the inhibitory effects of CSE on the 1,25-(OH(2))D(3)-induced translocation of VDR, but not in n-acetylcysteine.	Quercetin	0-9	vitamin D receptor	Homo sapiens	100-103
23009399-0	2012	Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria.	Quercetin	40-49	monoamine oxidase A	Mus musculus	94-113
23009399-1	2012	Quercetin, a typical dietary flavonoid, is thought to exert antidepressant effects by inhibiting the monoamine oxidase-A (MAO-A) reaction, which is responsible for regulation of the metabolism of the neurotransmitter 5-hydroxytryptamine (5-HT) in the brain.	Quercetin	0-9	monoamine oxidase A	Mus musculus	101-120
23009399-1	2012	Quercetin, a typical dietary flavonoid, is thought to exert antidepressant effects by inhibiting the monoamine oxidase-A (MAO-A) reaction, which is responsible for regulation of the metabolism of the neurotransmitter 5-hydroxytryptamine (5-HT) in the brain.	Quercetin	0-9	monoamine oxidase A	Mus musculus	122-127
23009399-3	2012	Quercetin was inferior to luteolin in the inhibition of MAO-A activity, whereas isorhamnetin, tamarixetin, and tea catechins scarcely exerted inhibitory activity.	Quercetin	0-9	monoamine oxidase A	Mus musculus	56-61
23009399-5	2012	These data suggest that quercetin is a weak (but safe) MAO-A inhibitor in the modulation of 5-HT levels in the brain.	Quercetin	24-33	monoamine oxidase A	Mus musculus	55-60
22482891-8	2012	Treatment of FA mice with the natural anti-oxidant Quercetin restores IR signaling and ameliorates the diabetes- and obesity-prone phenotypes.	Quercetin	51-60	insulin receptor	Mus musculus	70-72
22985515-0	2012	Quercetin protects neuroblastoma SH-SY5Y cells against oxidative stress by inhibiting expression of Kruppel-like factor 4.	Quercetin	0-9	Kruppel like factor 4	Homo sapiens	100-121
22846602-0	2012	Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	103-107
22846602-6	2012	The aim of the present study was to investigate the effects of supraphysiological concentrations of quercetin and its methyl and glucuronide metabolites (3"-O-methyl-quercetin and quercetin-3-O-glucuronide) on activation of AMPK and eNOS in human aortic endothelial cells (HAECs) and endothelial function in isolated aortic rings from C57BL mice.	Quercetin	100-109	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	224-228
22846602-9	2012	We also found that 5 and 10 muM quercetin and its metabolites can induce activation of AMPK and eNOS in human aortic endothelial cells, and lead to an increase in the concentrations of S-nitrosothiols and nitrite in cell culture media (P &lt; 0.05).	Quercetin	32-41	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	87-91
22846602-11	2012	They suggest that beneficial effects of quercetin on endothelial cell functions are in part mediated via AMPK pathway.	Quercetin	40-49	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	105-109
22902988-9	2012	Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl(4)-induced activation of nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase (COX-2).	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-156
22902988-9	2012	Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl(4)-induced activation of nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase (COX-2).	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
22902988-9	2012	Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl(4)-induced activation of nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase (COX-2).	Quercetin	0-9	tumor necrosis factor	Mus musculus	170-197
22902988-9	2012	Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl(4)-induced activation of nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase (COX-2).	Quercetin	0-9	tumor necrosis factor	Mus musculus	199-228
22902988-9	2012	Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl(4)-induced activation of nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase (COX-2).	Quercetin	0-9	cytochrome c oxidase II, mitochondrial	Mus musculus	230-235
22902988-10	2012	The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin.	Quercetin	103-112	nitric oxide synthase 2, inducible	Mus musculus	18-49
22902988-10	2012	The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin.	Quercetin	103-112	nitric oxide synthase 2, inducible	Mus musculus	51-55
22902988-12	2012	Quercetin more potently suppressed the expression of transforming growth factor-beta1 (TGF-beta1) than rutin.	Quercetin	0-9	transforming growth factor, beta 1	Mus musculus	53-85
22902988-12	2012	Quercetin more potently suppressed the expression of transforming growth factor-beta1 (TGF-beta1) than rutin.	Quercetin	0-9	transforming growth factor, beta 1	Mus musculus	87-96
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Quercetin	141-150	beclin 1	Homo sapiens	288-296
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Quercetin	141-150	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	310-317
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Quercetin	141-150	AKT serine/threonine kinase 1	Homo sapiens	326-329
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Quercetin	141-150	mechanistic target of rapamycin kinase	Homo sapiens	330-334
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Quercetin	141-150	forkhead box O1	Homo sapiens	336-341
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Quercetin	141-150	tumor protein p53	Homo sapiens	357-360
22684842-0	2012	Quercetin enhances hypoxia-mediated apoptosis via direct inhibition of AMPK activity in HCT116 colon cancer.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	71-75
22824072-0	2012	The effect of quercetin on human neutrophil elastase-induced mucin5AC expression in human airway epithelial cells.	Quercetin	14-23	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	61-69
22824072-3	2012	We investigated the effect of quercetin on mucin 5AC (MUC5AC) expression induced by human neutrophil elastase (HNE) in airway epithelial cells and its molecular mechanisms.	Quercetin	30-39	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	43-52
22824072-3	2012	We investigated the effect of quercetin on mucin 5AC (MUC5AC) expression induced by human neutrophil elastase (HNE) in airway epithelial cells and its molecular mechanisms.	Quercetin	30-39	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	54-60
22824072-3	2012	We investigated the effect of quercetin on mucin 5AC (MUC5AC) expression induced by human neutrophil elastase (HNE) in airway epithelial cells and its molecular mechanisms.	Quercetin	30-39	elastase, neutrophil expressed	Homo sapiens	90-109
22824072-6	2012	Quercetin suppressed gene transcription and protein expression of MUC5AC in a dose-dependent manner, with significant inhibition from 40 muM.	Quercetin	0-9	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	66-72
22824072-7	2012	mRNA and protein expressions of EGFR decreased markedly when pretreated with quercetin.	Quercetin	77-86	epidermal growth factor receptor	Homo sapiens	32-36
22824072-8	2012	Among three MAPK proteins, only phosphorylated ERK1/2 protein expression increased significantly after treatment with HNE alone and decreased significantly after pretreatment with quercetin.	Quercetin	180-189	mitogen-activated protein kinase 3	Homo sapiens	12-16
22824072-8	2012	Among three MAPK proteins, only phosphorylated ERK1/2 protein expression increased significantly after treatment with HNE alone and decreased significantly after pretreatment with quercetin.	Quercetin	180-189	mitogen-activated protein kinase 3	Homo sapiens	47-53
22824072-10	2012	These results suggest that quercetin can inhibit HNE-induced MUC5AC expression in human airway epithelial cells through PKC/EGFR/ERK signal transduction pathway.	Quercetin	27-36	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	61-67
22824072-10	2012	These results suggest that quercetin can inhibit HNE-induced MUC5AC expression in human airway epithelial cells through PKC/EGFR/ERK signal transduction pathway.	Quercetin	27-36	epidermal growth factor receptor	Homo sapiens	124-128
22824072-10	2012	These results suggest that quercetin can inhibit HNE-induced MUC5AC expression in human airway epithelial cells through PKC/EGFR/ERK signal transduction pathway.	Quercetin	27-36	mitogen-activated protein kinase 3	Homo sapiens	129-132
22988926-10	2012	In HepG2 cells, GBE and its ingredients, quercetin, kaempferol and isorhamnetin, could decrease the cellular triglyceride content and upregulate the expression and total activity of CPT1A, respectively.	Quercetin	41-50	carnitine palmitoyltransferase 1A	Homo sapiens	182-187
22810500-10	2012	The cardioprotective effect of GSK-3beta inhibitors was significantly attenuated by quercetin (4 mg/kg, i.p.	Quercetin	84-93	glycogen synthase kinase 3 beta	Rattus norvegicus	31-40
22945467-5	2012	Results indicated quercetin to be the most effective therapeutic candidate with respect to renal edema, hypertension, serum creatinine, hematocrit, cardiopathy, aorta calcification, glomerular amyloidosis, erythrocyte depletion in bone marrow, collagen deposition, expressions of TNF-alpha, cleaved caspase-3, IkappaBalpha, PPARalpha, and serum insulin.	Quercetin	18-27	tumor necrosis factor	Homo sapiens	280-289
22945467-5	2012	Results indicated quercetin to be the most effective therapeutic candidate with respect to renal edema, hypertension, serum creatinine, hematocrit, cardiopathy, aorta calcification, glomerular amyloidosis, erythrocyte depletion in bone marrow, collagen deposition, expressions of TNF-alpha, cleaved caspase-3, IkappaBalpha, PPARalpha, and serum insulin.	Quercetin	18-27	NFKB inhibitor alpha	Homo sapiens	310-322
22945467-5	2012	Results indicated quercetin to be the most effective therapeutic candidate with respect to renal edema, hypertension, serum creatinine, hematocrit, cardiopathy, aorta calcification, glomerular amyloidosis, erythrocyte depletion in bone marrow, collagen deposition, expressions of TNF-alpha, cleaved caspase-3, IkappaBalpha, PPARalpha, and serum insulin.	Quercetin	18-27	peroxisome proliferator activated receptor alpha	Homo sapiens	324-333
22945467-5	2012	Results indicated quercetin to be the most effective therapeutic candidate with respect to renal edema, hypertension, serum creatinine, hematocrit, cardiopathy, aorta calcification, glomerular amyloidosis, erythrocyte depletion in bone marrow, collagen deposition, expressions of TNF-alpha, cleaved caspase-3, IkappaBalpha, PPARalpha, and serum insulin.	Quercetin	18-27	insulin	Homo sapiens	345-352
22945467-7	2012	As for signaling, quercetin was completely effective in alleviating the cleaved caspase-3, being only partially effective in suppressing Bax and Bad, restoring Bcl-2, and rescuing DNA damage.	Quercetin	18-27	BCL2 associated X, apoptosis regulator	Homo sapiens	137-140
22945467-7	2012	As for signaling, quercetin was completely effective in alleviating the cleaved caspase-3, being only partially effective in suppressing Bax and Bad, restoring Bcl-2, and rescuing DNA damage.	Quercetin	18-27	BCL2 apoptosis regulator	Homo sapiens	160-165
22490108-11	2012	Arecoline-induced HSP27 expression was downregulated by EGCG, NS398, NAC, quercetin, PD98059, and SB203580.	Quercetin	74-83	heat shock protein family B (small) member 1	Homo sapiens	18-23
22872589-3	2012	However, the molecular mechanisms by which anthocyanins (delphinidin and cyanin) and quercetin regulate the renin-angiotensin system are not completely understood.	Quercetin	85-94	renin	Homo sapiens	108-113
22872589-4	2012	In this study, we demonstrate that delphinidin, cyanin, and quercetin interrupt the renin-angiotensin system signaling pathway by inhibiting the angiotensin-converting enzyme activity and decreasing its mRNA production.	Quercetin	60-69	renin	Homo sapiens	84-89
22924393-3	2012	To selectively target advanced prostate tumors with a constitutive activated PI3K/Akt pathway, a prostate cancer-specific PI3K inhibitor was generated by coupling the chemically modified form of the quercetin analogue LY294002 (HO-CH(2)-LY294002, compound 8) with the peptide Mu-LEHSSKLQL, in which the internal sequence HSSKLQ is a substrate for the prostate-specific antigen (PSA) protease.	Quercetin	199-208	AKT serine/threonine kinase 1	Homo sapiens	82-85
22728078-8	2012	Quercetin also reduced the expression of matrix metalloproteinase (MMP)-2, MMP-9, cathepsin B, and cathepsin K in aortic tissue.	Quercetin	0-9	matrix metallopeptidase 2	Mus musculus	41-73
22728078-8	2012	Quercetin also reduced the expression of matrix metalloproteinase (MMP)-2, MMP-9, cathepsin B, and cathepsin K in aortic tissue.	Quercetin	0-9	matrix metallopeptidase 9	Mus musculus	75-80
22728078-8	2012	Quercetin also reduced the expression of matrix metalloproteinase (MMP)-2, MMP-9, cathepsin B, and cathepsin K in aortic tissue.	Quercetin	0-9	cathepsin B	Mus musculus	82-93
22728078-8	2012	Quercetin also reduced the expression of matrix metalloproteinase (MMP)-2, MMP-9, cathepsin B, and cathepsin K in aortic tissue.	Quercetin	0-9	cathepsin K	Mus musculus	99-110
22728078-9	2012	In addition, quercetin treatment increased tissue inhibitors of metalloproteinases (TIMP)-1 gene expression.	Quercetin	13-22	tissue inhibitor of metalloproteinase 1	Mus musculus	43-91
22445558-6	2012	RESULTS: The specific activity of N-acetyl-beta-d-glucosaminidase in liver of diabetic rats was decreased when compared to control rats and was ameliorated with curcumin and quercetin treatment by 67% and 78%, respectively.	Quercetin	174-183	O-GlcNAcase	Rattus norvegicus	34-65
22824072-0	2012	The effect of quercetin on human neutrophil elastase-induced mucin5AC expression in human airway epithelial cells.	Quercetin	14-23	elastase, neutrophil expressed	Homo sapiens	33-52
22872589-0	2012	Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin.	Quercetin	71-80	renin	Homo sapiens	16-21
22902249-8	2012	The protein expression of superoxide dismutase (Cu/Zn-SOD, Mn-SOD), glutathione peroxidase (GPx) and endothelial nitric oxide synthase (eNOS) increased in the cells treated with CQE, quercetin or resveratrol prior to H(2)O(2) exposure, as compared with control.	Quercetin	183-192	nitric oxide synthase 3	Homo sapiens	101-134
22867086-0	2012	Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR).	Quercetin	0-9	aryl hydrocarbon receptor	Homo sapiens	68-93
22867086-0	2012	Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR).	Quercetin	0-9	aryl hydrocarbon receptor	Homo sapiens	95-98
22867086-2	2012	The aim of this study was to investigate whether quercetin (QUE), resveratrol (RES), and curcumin (CUR) interfere with the metabolic degradation of the suggested endogenous AHR ligand 6-formylindolo[3,2-b]carbazole (FICZ) and thereby indirectly activate the AHR.	Quercetin	49-58	aryl hydrocarbon receptor	Homo sapiens	173-176
22867086-2	2012	The aim of this study was to investigate whether quercetin (QUE), resveratrol (RES), and curcumin (CUR) interfere with the metabolic degradation of the suggested endogenous AHR ligand 6-formylindolo[3,2-b]carbazole (FICZ) and thereby indirectly activate the AHR.	Quercetin	49-58	aryl hydrocarbon receptor	Homo sapiens	258-261
22867086-2	2012	The aim of this study was to investigate whether quercetin (QUE), resveratrol (RES), and curcumin (CUR) interfere with the metabolic degradation of the suggested endogenous AHR ligand 6-formylindolo[3,2-b]carbazole (FICZ) and thereby indirectly activate the AHR.	Quercetin	60-63	aryl hydrocarbon receptor	Homo sapiens	173-176
22867086-2	2012	The aim of this study was to investigate whether quercetin (QUE), resveratrol (RES), and curcumin (CUR) interfere with the metabolic degradation of the suggested endogenous AHR ligand 6-formylindolo[3,2-b]carbazole (FICZ) and thereby indirectly activate the AHR.	Quercetin	60-63	aryl hydrocarbon receptor	Homo sapiens	258-261
22684842-3	2012	Quercetin significantly attenuated tumor growth in an HCT116 cancer xenograft in vivo model with a substantial reduction of AMPK activity.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	124-128
22684842-4	2012	In a cell culture system, quercetin more dramatically induced apoptosis of HCT116 cancer cells under hypoxic conditions than normoxic conditions, and this was tightly associated with inhibition of hypoxia-induced AMPK activity.	Quercetin	26-35	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	213-217
22684842-5	2012	An in vitro kinase assay demonstrated that quercetin directly inhibits AMPK activity.	Quercetin	43-52	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	71-75
22684842-6	2012	Inhibition of AMPK by expressing a dominant-negative form resulted in an increase of apoptosis under hypoxia, and a constitutively active form of AMPK effectively blocked quercetin-induced apoptosis under hypoxia.	Quercetin	171-180	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18
22684842-6	2012	Inhibition of AMPK by expressing a dominant-negative form resulted in an increase of apoptosis under hypoxia, and a constitutively active form of AMPK effectively blocked quercetin-induced apoptosis under hypoxia.	Quercetin	171-180	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	146-150
22684842-7	2012	Collectively, our data suggest that quercetin directly inhibits hypoxia-induced AMPK, which plays a protective role against hypoxia.	Quercetin	36-45	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	80-84
22684842-8	2012	Quercetin also reduced the activity of hypoxia-inducible factor-1 (HIF-1), a major transcription factor for adaptive cellular response to hypoxia.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-65
22684842-8	2012	Quercetin also reduced the activity of hypoxia-inducible factor-1 (HIF-1), a major transcription factor for adaptive cellular response to hypoxia.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72
22711909-8	2012	These findings provide evidence that p38 signaling is essential for the regulation of quercetin-induced ABCA1 expression and cholesterol efflux in macrophages.	Quercetin	86-95	mitogen-activated protein kinase 14	Homo sapiens	37-40
22711909-8	2012	These findings provide evidence that p38 signaling is essential for the regulation of quercetin-induced ABCA1 expression and cholesterol efflux in macrophages.	Quercetin	86-95	ATP binding cassette subfamily A member 1	Homo sapiens	104-109
22711909-0	2012	Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages.	Quercetin	0-9	ATP binding cassette subfamily A member 1	Homo sapiens	19-24
22119371-11	2012	The mechanistic studies demonstrated that quercetin induced radio-sensitization is through inhibiting the ATM kinase, one of the critical DNA damage response proteins.	Quercetin	42-51	ATM serine/threonine kinase	Homo sapiens	106-109
22711909-0	2012	Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	69-72
22711909-3	2012	This study is aimed to investigate the effect of quercetin on regulation of ABCA1 expression and to explore its underlying mechanisms in macrophages.	Quercetin	49-58	ATP binding cassette subfamily A member 1	Homo sapiens	76-81
22711909-4	2012	The results show that quercetin markedly enhanced cholesterol efflux from macrophages in a concentration-dependent manner, which was associated with an increase in ABCA1 mRNA and protein expression.	Quercetin	22-31	ATP binding cassette subfamily A member 1	Homo sapiens	164-169
22711909-5	2012	Remarkably, quercetin is able to stimulate the phosphorylation of p38 by up to 234-fold at 6 h via an activation of the transforming growth factor beta-activated kinase 1 (TAK1) and mitogen-activated kinase kinase 3/6 (MKK3/6).	Quercetin	12-21	mitogen-activated protein kinase 14	Homo sapiens	66-69
22711909-5	2012	Remarkably, quercetin is able to stimulate the phosphorylation of p38 by up to 234-fold at 6 h via an activation of the transforming growth factor beta-activated kinase 1 (TAK1) and mitogen-activated kinase kinase 3/6 (MKK3/6).	Quercetin	12-21	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	120-170
22711909-5	2012	Remarkably, quercetin is able to stimulate the phosphorylation of p38 by up to 234-fold at 6 h via an activation of the transforming growth factor beta-activated kinase 1 (TAK1) and mitogen-activated kinase kinase 3/6 (MKK3/6).	Quercetin	12-21	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	172-176
22711909-5	2012	Remarkably, quercetin is able to stimulate the phosphorylation of p38 by up to 234-fold at 6 h via an activation of the transforming growth factor beta-activated kinase 1 (TAK1) and mitogen-activated kinase kinase 3/6 (MKK3/6).	Quercetin	12-21	mitogen-activated protein kinase kinase 3	Homo sapiens	219-225
22711909-6	2012	Inhibition of p38 with a pharmacological inhibitor or small hairpin RNA (shRNA) suppressed the stimulatory effects of quercetin on ABCA1 expression and cholesterol efflux.	Quercetin	118-127	mitogen-activated protein kinase 14	Homo sapiens	14-17
22711909-6	2012	Inhibition of p38 with a pharmacological inhibitor or small hairpin RNA (shRNA) suppressed the stimulatory effects of quercetin on ABCA1 expression and cholesterol efflux.	Quercetin	118-127	ATP binding cassette subfamily A member 1	Homo sapiens	131-136
22711909-7	2012	Moreover, knockdown of p38 reduced quercetin-enhanced ABCA1 promoter activity and the binding of specificity protein 1 (Sp1) and liver X receptor alpha (LXRalpha) to the ABCA1 promoter using chromatin immunoprecipitation assays.	Quercetin	35-44	mitogen-activated protein kinase 14	Homo sapiens	23-26
22711909-7	2012	Moreover, knockdown of p38 reduced quercetin-enhanced ABCA1 promoter activity and the binding of specificity protein 1 (Sp1) and liver X receptor alpha (LXRalpha) to the ABCA1 promoter using chromatin immunoprecipitation assays.	Quercetin	35-44	ATP binding cassette subfamily A member 1	Homo sapiens	54-59
22864987-0	2012	Human quercetin conjugated metabolites attenuate TNF-alpha-induced changes in vasomodulatory molecules in an HUASMCs/HUVECs co-culture model.	Quercetin	6-15	tumor necrosis factor	Homo sapiens	49-58
22864987-4	2012	We observed that physiologically relevant metabolites of quercetin were able to reduce ET-1 protein and gene expression and to increase accumulation of cGMP in TNF-alpha-induced HUASMCs co-cultured with HUVECs.	Quercetin	57-66	endothelin 1	Homo sapiens	87-91
22864987-4	2012	We observed that physiologically relevant metabolites of quercetin were able to reduce ET-1 protein and gene expression and to increase accumulation of cGMP in TNF-alpha-induced HUASMCs co-cultured with HUVECs.	Quercetin	57-66	tumor necrosis factor	Homo sapiens	160-169
22119371-12	2012	CONCLUSION: We demonstrate both in vitro and in vivo evidence that combination of quercetin with radiotherapy can enhance tumor radiosensitivity by targeting the ATM-mediated pathway in response to radiation.	Quercetin	82-91	ATM serine/threonine kinase	Homo sapiens	162-165
22661653-8	2012	Quercetin reduced IL-6, IL-8 and TNFalpha protein production in supernatants of all GO samples (n=4) in a dose-dependent manner; however, only the reduction in IL-6 was statistically significant (p&lt;0.05).	Quercetin	0-9	interleukin 6	Homo sapiens	18-22
22713545-7	2012	Quercetin treatment improved whole body insulin sensitivity by increasing GLUT4 expression and decreasing JNK phosphorylation, and TNFalpha and iNOS expression in skeletal muscle.	Quercetin	0-9	tumor necrosis factor	Mus musculus	131-139
22713545-8	2012	Quercetin suppressed palmitate-induced upregulation of TNFalpha and iNOS and restored normal levels of GLUT4 in myotubes.	Quercetin	0-9	tumor necrosis factor	Mus musculus	55-63
22713545-8	2012	Quercetin suppressed palmitate-induced upregulation of TNFalpha and iNOS and restored normal levels of GLUT4 in myotubes.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	68-72
22713545-8	2012	Quercetin suppressed palmitate-induced upregulation of TNFalpha and iNOS and restored normal levels of GLUT4 in myotubes.	Quercetin	0-9	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	103-108
22713545-9	2012	In parallel, quercetin suppressed TNFalpha-induced reduction of glucose uptake in myotubes.	Quercetin	13-22	tumor necrosis factor	Mus musculus	34-42
22713545-10	2012	Nuclear accumulation of NF-kappaB in myotubes and binding of NF-kappaB to GLUT4 promoter in muscles of ob/ob mice were also reduced by quercetin.	Quercetin	135-144	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	74-79
22871832-8	2012	In primary cells, quercetin dose-dependently downregulated expression of TGF-beta-stimulated fibronectin and collagen Ialpha, and IL-1beta-enhanced MMP-2 and MMP-9.	Quercetin	18-27	fibronectin 1	Homo sapiens	93-104
22871832-8	2012	In primary cells, quercetin dose-dependently downregulated expression of TGF-beta-stimulated fibronectin and collagen Ialpha, and IL-1beta-enhanced MMP-2 and MMP-9.	Quercetin	18-27	interleukin 1 beta	Homo sapiens	130-138
22871832-8	2012	In primary cells, quercetin dose-dependently downregulated expression of TGF-beta-stimulated fibronectin and collagen Ialpha, and IL-1beta-enhanced MMP-2 and MMP-9.	Quercetin	18-27	matrix metallopeptidase 2	Homo sapiens	148-153
22871832-8	2012	In primary cells, quercetin dose-dependently downregulated expression of TGF-beta-stimulated fibronectin and collagen Ialpha, and IL-1beta-enhanced MMP-2 and MMP-9.	Quercetin	18-27	matrix metallopeptidase 9	Homo sapiens	158-163
22871832-9	2012	However, without IL-1beta stimulation, 10-50 muM of quercetin increased MMP-2 expression and activity, but dose-dependently suppressed MMP-9 expression and activity.	Quercetin	52-61	matrix metallopeptidase 2	Homo sapiens	72-77
22871832-9	2012	However, without IL-1beta stimulation, 10-50 muM of quercetin increased MMP-2 expression and activity, but dose-dependently suppressed MMP-9 expression and activity.	Quercetin	52-61	matrix metallopeptidase 9	Homo sapiens	135-140
22871832-10	2012	In tissue cultures, quercetin dose-dependently inhibited MMP-2 and -9 activity and secretion, but 30 and 50 muM of quercetin increased tissue MMP-2 mRNA.	Quercetin	20-29	matrix metallopeptidase 2	Homo sapiens	57-69
22871832-10	2012	In tissue cultures, quercetin dose-dependently inhibited MMP-2 and -9 activity and secretion, but 30 and 50 muM of quercetin increased tissue MMP-2 mRNA.	Quercetin	20-29	matrix metallopeptidase 2	Homo sapiens	57-62
22871832-12	2012	CONCLUSIONS: Quercetin inhibited fibrotic markers and affected MMP-2 and MMP-9 activities in primary cell and orbital fat tissue cultures from GO at nontoxic concentrations.	Quercetin	13-22	matrix metallopeptidase 2	Homo sapiens	63-68
22871832-12	2012	CONCLUSIONS: Quercetin inhibited fibrotic markers and affected MMP-2 and MMP-9 activities in primary cell and orbital fat tissue cultures from GO at nontoxic concentrations.	Quercetin	13-22	matrix metallopeptidase 9	Homo sapiens	73-78
22713545-7	2012	Quercetin treatment improved whole body insulin sensitivity by increasing GLUT4 expression and decreasing JNK phosphorylation, and TNFalpha and iNOS expression in skeletal muscle.	Quercetin	0-9	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	74-79
22713545-7	2012	Quercetin treatment improved whole body insulin sensitivity by increasing GLUT4 expression and decreasing JNK phosphorylation, and TNFalpha and iNOS expression in skeletal muscle.	Quercetin	0-9	mitogen-activated protein kinase 8	Mus musculus	106-109
22661653-8	2012	Quercetin reduced IL-6, IL-8 and TNFalpha protein production in supernatants of all GO samples (n=4) in a dose-dependent manner; however, only the reduction in IL-6 was statistically significant (p&lt;0.05).	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	24-28
22661653-8	2012	Quercetin reduced IL-6, IL-8 and TNFalpha protein production in supernatants of all GO samples (n=4) in a dose-dependent manner; however, only the reduction in IL-6 was statistically significant (p&lt;0.05).	Quercetin	0-9	tumor necrosis factor	Homo sapiens	33-41
22661653-8	2012	Quercetin reduced IL-6, IL-8 and TNFalpha protein production in supernatants of all GO samples (n=4) in a dose-dependent manner; however, only the reduction in IL-6 was statistically significant (p&lt;0.05).	Quercetin	0-9	interleukin 6	Homo sapiens	160-164
22661653-9	2012	Quercetin had a significant suppression of tissue IL-6, IL-8, IL-1beta and TNFalpha mRNA expression in cultured orbital tissues from three GO samples relative to untreated control tissue (p&lt;0.05).	Quercetin	0-9	interleukin 6	Homo sapiens	50-54
22661653-9	2012	Quercetin had a significant suppression of tissue IL-6, IL-8, IL-1beta and TNFalpha mRNA expression in cultured orbital tissues from three GO samples relative to untreated control tissue (p&lt;0.05).	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
22661653-9	2012	Quercetin had a significant suppression of tissue IL-6, IL-8, IL-1beta and TNFalpha mRNA expression in cultured orbital tissues from three GO samples relative to untreated control tissue (p&lt;0.05).	Quercetin	0-9	interleukin 1 beta	Homo sapiens	62-70
22661653-9	2012	Quercetin had a significant suppression of tissue IL-6, IL-8, IL-1beta and TNFalpha mRNA expression in cultured orbital tissues from three GO samples relative to untreated control tissue (p&lt;0.05).	Quercetin	0-9	tumor necrosis factor	Homo sapiens	75-83
22830632-7	2012	An inducing effect of curcumin and quercetin on GST or UGT was seen in Caco-2, LT97, and HuTu 80 cells.	Quercetin	35-44	glutathione S-transferase kappa 1	Homo sapiens	48-51
22647223-0	2012	Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors.	Quercetin	93-102	coagulation factor II, thrombin	Homo sapiens	106-114
22647223-5	2012	The findings of this study would provide information for the exploitation and utilization of quercetin as thrombin inhibitor for thrombotic disease treatment.	Quercetin	93-102	coagulation factor II, thrombin	Homo sapiens	106-114
22613215-5	2012	Icaritin (ICT) and quercetin exhibited in vitro ER mediated estrogenic activity with a more potent interaction with ERbeta.	Quercetin	19-28	estrogen receptor 2	Homo sapiens	116-122
21909718-0	2012	Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice.	Quercetin	0-9	uromodulin	Mus musculus	48-58
21909718-13	2012	CONCLUSIONS: These results suggest that quercetin has the uricosuric and nephroprotective actions mediated by regulating the expression levels of renal organic ion transporters and UMOD.	Quercetin	40-49	uromodulin	Mus musculus	181-185
22592909-0	2012	Quercetin inhibits IL-1beta-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	19-27
22592909-0	2012	Quercetin inhibits IL-1beta-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast.	Quercetin	0-9	matrix metallopeptidase 1	Homo sapiens	68-72
22592909-0	2012	Quercetin inhibits IL-1beta-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
22592909-1	2012	This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs.	Quercetin	49-58	interleukin 1 beta	Homo sapiens	66-83
22592909-1	2012	This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs.	Quercetin	49-58	interleukin 1 beta	Homo sapiens	85-93
22592909-1	2012	This study was aimed to determine the effects of quercetin on the interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid synovial fibroblasts (RASFs) and production of matrix metalloproteinases (MMPs), cyclooxygenase (COX), and prostaglandin E2 (PGE2) by RASFs.	Quercetin	49-58	matrix metallopeptidase 1	Homo sapiens	205-209
22592909-4	2012	Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	36-44
22592909-4	2012	Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta.	Quercetin	0-9	matrix metallopeptidase 1	Homo sapiens	80-85
22592909-4	2012	Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
22592909-4	2012	Quercetin inhibits unstimulated and IL-1beta-induced proliferation of RASFs and MMP-1, 3, COX-2 messenger ribonucleic acid and protein expression, PGE2 production induced with IL-1beta.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	176-184
22592909-5	2012	Quercetin also inhibits the phosphorylation of ERK-1/2, p38, JNK and activation of NF-kB by IL-1ed.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	47-54
22592909-5	2012	Quercetin also inhibits the phosphorylation of ERK-1/2, p38, JNK and activation of NF-kB by IL-1ed.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	56-59
22592909-5	2012	Quercetin also inhibits the phosphorylation of ERK-1/2, p38, JNK and activation of NF-kB by IL-1ed.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	61-64
22592909-5	2012	Quercetin also inhibits the phosphorylation of ERK-1/2, p38, JNK and activation of NF-kB by IL-1ed.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	92-96
22592909-6	2012	These results indicate that quercetin inhibits synovial fibroblasts proliferation and MMPs, COX-2, and PGE2 production, which involved joint destruction in rheumatoid arthritis (RA), and suggest that it might be a new therapeutic agent for management of RA.	Quercetin	28-37	matrix metallopeptidase 1	Homo sapiens	86-90
22592909-6	2012	These results indicate that quercetin inhibits synovial fibroblasts proliferation and MMPs, COX-2, and PGE2 production, which involved joint destruction in rheumatoid arthritis (RA), and suggest that it might be a new therapeutic agent for management of RA.	Quercetin	28-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	92-97
22977683-8	2012	After 30 days of radiation, interleukin (IL)-1beta and IL-6 secretion decreased significantly in the radiation-quercetin groups.	Quercetin	111-120	interleukin 1 beta	Mus musculus	28-50
22977683-8	2012	After 30 days of radiation, interleukin (IL)-1beta and IL-6 secretion decreased significantly in the radiation-quercetin groups.	Quercetin	111-120	interleukin 6	Mus musculus	55-59
22830632-7	2012	An inducing effect of curcumin and quercetin on GST or UGT was seen in Caco-2, LT97, and HuTu 80 cells.	Quercetin	35-44	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	55-58
22830632-9	2012	In LT97 cells, GST activity and expression was reduced, but UGT1 expression was induced by curcumin and quercetin; whereas EPA only decreased GST or UGT levels.	Quercetin	104-113	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	60-64
22830632-9	2012	In LT97 cells, GST activity and expression was reduced, but UGT1 expression was induced by curcumin and quercetin; whereas EPA only decreased GST or UGT levels.	Quercetin	104-113	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	60-63
22809533-8	2012	RESULTS: At 100 muM, quercetin inhibited cell proliferation and decreased expression of FASN and Ki67 antigen.	Quercetin	21-30	fatty acid synthase	Homo sapiens	88-92
22564824-5	2012	Studies in mice and human subjects indicate that the apoE epsilon3 but not the apoE epsilon4 genotype may significantly benefit from dietary flavonoids (e.g. quercetin) and n-3 fatty acids.	Quercetin	158-167	apolipoprotein E	Homo sapiens	53-57
22410438-10	2012	In fact, in the presence of ERalpha, both naringenin and quercetin decouple ERalpha activities by specifically interfering with ERalpha membrane initiating signals.	Quercetin	57-66	estrogen receptor 1	Homo sapiens	28-35
22410438-10	2012	In fact, in the presence of ERalpha, both naringenin and quercetin decouple ERalpha activities by specifically interfering with ERalpha membrane initiating signals.	Quercetin	57-66	estrogen receptor 1	Homo sapiens	76-83
22410438-10	2012	In fact, in the presence of ERalpha, both naringenin and quercetin decouple ERalpha activities by specifically interfering with ERalpha membrane initiating signals.	Quercetin	57-66	estrogen receptor 1	Homo sapiens	76-83
22775419-6	2012	This study also revealed that quercetin administration significantly reduced the activity of serum alanine aminotransferase (41%), aspartate aminotransferase (51%), and gamma-glutamyl transpeptidase (G-GT) (35%).	Quercetin	30-39	gamma-glutamyltransferase 1	Rattus norvegicus	169-198
22775419-6	2012	This study also revealed that quercetin administration significantly reduced the activity of serum alanine aminotransferase (41%), aspartate aminotransferase (51%), and gamma-glutamyl transpeptidase (G-GT) (35%).	Quercetin	30-39	gamma-glutamyltransferase 1	Rattus norvegicus	200-204
22698256-6	2012	Furthermore, resveratrol, pterostilbene, morin hydrate, and quercetin suppressed secretion of TNF-alpha (&gt;40%; P &lt; 0.05) in LPS-stimulated RAW 264.7 cells, and suppressed NF-kappaB activation (22% to 45%; P &lt; 0.05) in LPS-stimulated HEK293T cells.	Quercetin	60-69	tumor necrosis factor	Mus musculus	94-103
25683418-7	2012	This study indicates that quercetin metabolites decrease the BaP-induced harmful effect of beta-carotene in A549 cells by downregulating the expression of CYP1A1/1A2, at least in part.	Quercetin	26-35	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	155-161
22497768-4	2012	The IC(50) values of three well-known 15-LOX-1 inhibitors, nordihydroguaiaretic acid, quercetin, and fisetin, were evaluated in 96- and 384-well formats, and they conform to previously reported data.	Quercetin	86-95	arachidonate 15-lipoxygenase	Homo sapiens	38-46
22783269-5	2012	Furthermore, we analyzed the root tissue metabolites of these seven ABC transporter mutants and found that the levels of SA, quercetin, and kaempferol glucosides were higher in Atabcg36, which was correlated with higher expression levels of defense genes in the root tissues compared with the wild type.	Quercetin	125-134	ABC-2 and Plant PDR ABC-type transporter family protein	Arabidopsis thaliana	177-185
21796625-8	2012	Furthermore, combination of quercetin with EGCG had synergistic inhibitory effects on self-renewal capacity of CSCs through attenuation of TCF/LEF and Gli activities.	Quercetin	28-37	hepatocyte nuclear factor 4 alpha	Homo sapiens	139-146
22426011-7	2012	The NLRP3 inflammasome may be the target mediating the improvement of urate-lowering agents allopurinol, quercetin and rutin on fructose-induced renal lipid accumulation and injury.	Quercetin	105-114	NLR family, pyrin domain containing 3	Rattus norvegicus	4-9
22579112-9	2012	These results suggest that quercetin or naringenin might possibly be able to protect beta-cells from cytokines toxicity by enhancing cell survival through PI3-kinase pathway, independent of p-p38 MAPK or iNOS.	Quercetin	27-36	mitogen-activated protein kinase 14	Homo sapiens	192-195
22829699-2	2012	This study was designed to investigate the protective effect of QUE on oxidized low-density lipoprotein (ox-LDL)-induced cytotoxicity in RAW264.7 macrophages and specifically the endoplasmic reticulum (ER) stress-C/EBP homologous protein (CHOP) pathway-mediated apoptosis.	Quercetin	64-67	DNA-damage inducible transcript 3	Mus musculus	239-243
22731722-4	2012	Incubation with TNF-alpha led to a decrease of R(T)  in HT-29/B6 cell monolayers, which could be partially inhibited by quercetin.	Quercetin	120-129	tumor necrosis factor	Homo sapiens	16-25
22731722-6	2012	Thus, barrier disturbance in late distal colon specimens induced by TNF-alpha and IFN-gamma could be partially prevented by coincubation with quercetin.	Quercetin	142-151	tumor necrosis factor	Rattus norvegicus	68-77
22731722-6	2012	Thus, barrier disturbance in late distal colon specimens induced by TNF-alpha and IFN-gamma could be partially prevented by coincubation with quercetin.	Quercetin	142-151	interferon gamma	Rattus norvegicus	82-91
22758641-2	2012	We recently demonstrated that the flavonoid quercetin, naturally present in the diet and belonging to the class of phytochemicals, is able to sensitize several leukemia cell lines and B cells isolated from patients affected by chronic lymphocytic leukemia (B-CLL), in addition to apoptotic inducers (anti-CD95 and rTRAIL).	Quercetin	44-53	Fas cell surface death receptor	Homo sapiens	305-309
22758641-2	2012	We recently demonstrated that the flavonoid quercetin, naturally present in the diet and belonging to the class of phytochemicals, is able to sensitize several leukemia cell lines and B cells isolated from patients affected by chronic lymphocytic leukemia (B-CLL), in addition to apoptotic inducers (anti-CD95 and rTRAIL).	Quercetin	44-53	TNF superfamily member 10	Rattus norvegicus	314-320
22758641-4	2012	The proapoptotic activity of quercetin in cell lines and B-CLL is related to the expression and activity of Mcl-1-antiapoptotic proteins belonging to the Bcl-2 family.	Quercetin	29-38	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	108-113
22758641-4	2012	The proapoptotic activity of quercetin in cell lines and B-CLL is related to the expression and activity of Mcl-1-antiapoptotic proteins belonging to the Bcl-2 family.	Quercetin	29-38	BCL2 apoptosis regulator	Homo sapiens	154-159
22758641-5	2012	Quercetin downregulates Mcl-1 mRNA and protein levels acting on mRNA stability and protein degradation.	Quercetin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	24-29
22426011-0	2012	Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats.	Quercetin	13-22	NLR family, pyrin domain containing 3	Rattus norvegicus	50-55
22426011-5	2012	The restoration of fructose-induced hyperuricemia and dyslipidemia by the treatment of allopurinol, quercetin and rutin blocked the NLRP3 inflammasome activation to improve the signaling impairments and reduce lipid accumulation in the kidney of rats.	Quercetin	100-109	NLR family, pyrin domain containing 3	Rattus norvegicus	132-137
22510202-10	2012	Nuclear accumulation of beta-catenin was detected in Gdeg(high), but not Gdeg(low), and lost after exposure to quercetin.	Quercetin	111-120	catenin (cadherin associated protein), beta 1	Mus musculus	24-36
22469745-0	2012	Quercetin suppresses NF-kappaB and MCP-1 expression in a high glucose-induced             human mesangial cell proliferation model.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	21-30
22469745-0	2012	Quercetin suppresses NF-kappaB and MCP-1 expression in a high glucose-induced             human mesangial cell proliferation model.	Quercetin	0-9	C-C motif chemokine ligand 2	Homo sapiens	35-40
22469745-9	2012	Cotreatment of quercetin with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activation, suggest that the effects of quercetin are partially mediated by NF-kappaB signaling.	Quercetin	15-24	nuclear factor kappa B subunit 1	Homo sapiens	82-91
22469745-9	2012	Cotreatment of quercetin with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activation, suggest that the effects of quercetin are partially mediated by NF-kappaB signaling.	Quercetin	15-24	nuclear factor kappa B subunit 1	Homo sapiens	168-177
22469745-9	2012	Cotreatment of quercetin with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activation, suggest that the effects of quercetin are partially mediated by NF-kappaB signaling.	Quercetin	132-141	nuclear factor kappa B subunit 1	Homo sapiens	82-91
22469745-9	2012	Cotreatment of quercetin with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activation, suggest that the effects of quercetin are partially mediated by NF-kappaB signaling.	Quercetin	132-141	nuclear factor kappa B subunit 1	Homo sapiens	168-177
22469745-10	2012	Quercetin partially suppresses the effects of high glucose in HMC cultures, which are mediated at least in part through the suppression of NF-kappaB.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	139-148
21796625-8	2012	Furthermore, combination of quercetin with EGCG had synergistic inhibitory effects on self-renewal capacity of CSCs through attenuation of TCF/LEF and Gli activities.	Quercetin	28-37	GLI family zinc finger 1	Homo sapiens	151-154
22555976-0	2012	Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	60-63
22334599-3	2012	Therefore, pregnant mice were supplemented with the natural aryl hydrocarbon receptor (AhR) agonist quercetin (1 mmol quercetin/kg feed) until delivery.	Quercetin	100-109	aryl-hydrocarbon receptor	Mus musculus	60-85
22334599-3	2012	Therefore, pregnant mice were supplemented with the natural aryl hydrocarbon receptor (AhR) agonist quercetin (1 mmol quercetin/kg feed) until delivery.	Quercetin	100-109	aryl-hydrocarbon receptor	Mus musculus	87-90
22334599-5	2012	In utero quercetin exposure resulted in significantly enhanced gene expression of Cyp1a1, Cyp1b1, Nqo1 and Ugt1a6 in liver of foetuses at Day 14.5 of gestation.	Quercetin	9-18	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	82-88
22334599-5	2012	In utero quercetin exposure resulted in significantly enhanced gene expression of Cyp1a1, Cyp1b1, Nqo1 and Ugt1a6 in liver of foetuses at Day 14.5 of gestation.	Quercetin	9-18	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	90-96
22334599-5	2012	In utero quercetin exposure resulted in significantly enhanced gene expression of Cyp1a1, Cyp1b1, Nqo1 and Ugt1a6 in liver of foetuses at Day 14.5 of gestation.	Quercetin	9-18	NAD(P)H dehydrogenase, quinone 1	Mus musculus	98-102
22334599-5	2012	In utero quercetin exposure resulted in significantly enhanced gene expression of Cyp1a1, Cyp1b1, Nqo1 and Ugt1a6 in liver of foetuses at Day 14.5 of gestation.	Quercetin	9-18	UDP glucuronosyltransferase 1 family, polypeptide A6A	Mus musculus	107-113
22488120-3	2012	By using male Sprague-Dawley rats, the movement of glucosamine through everted gut, the effect of dose and glucose, and inhibition of a glucose transporter (GLUT2) by quercetin were studied.	Quercetin	167-176	solute carrier family 2 member 2	Rattus norvegicus	157-162
22334599-7	2012	Expression of Phase I enzymes (Cyp1a1 and Cyp1b1) was up-regulated in the liver of adult female mice in utero exposed to quercetin, whereas expression of Phase II enzymes (Gstp1, Nqo1 and Ugt1a6) was predominantly enhanced in the lung tissue of female mice.	Quercetin	121-130	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	31-37
22555976-4	2012	Quercetin caused leukemia cells apoptosis by decreasing the protein expression of PI3K and Bax, the inhibitory phosphorylation of Akt, the decreased levels of Bcl-2 protein and increased activations of caspase-2 and -3, and increased poly(ADP-ribose) polymerase cleavage.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94
22334599-7	2012	Expression of Phase I enzymes (Cyp1a1 and Cyp1b1) was up-regulated in the liver of adult female mice in utero exposed to quercetin, whereas expression of Phase II enzymes (Gstp1, Nqo1 and Ugt1a6) was predominantly enhanced in the lung tissue of female mice.	Quercetin	121-130	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	42-48
22555976-4	2012	Quercetin caused leukemia cells apoptosis by decreasing the protein expression of PI3K and Bax, the inhibitory phosphorylation of Akt, the decreased levels of Bcl-2 protein and increased activations of caspase-2 and -3, and increased poly(ADP-ribose) polymerase cleavage.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	130-133
22555976-4	2012	Quercetin caused leukemia cells apoptosis by decreasing the protein expression of PI3K and Bax, the inhibitory phosphorylation of Akt, the decreased levels of Bcl-2 protein and increased activations of caspase-2 and -3, and increased poly(ADP-ribose) polymerase cleavage.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	159-164
22555976-4	2012	Quercetin caused leukemia cells apoptosis by decreasing the protein expression of PI3K and Bax, the inhibitory phosphorylation of Akt, the decreased levels of Bcl-2 protein and increased activations of caspase-2 and -3, and increased poly(ADP-ribose) polymerase cleavage.	Quercetin	0-9	caspase 2	Homo sapiens	202-218
22555976-5	2012	Our results indicate that the apoptotic processes caused by quercetin are mediated by the decrease of pAkt and Bcl-2 levels, the increase of Bax level, and the activation of caspase families in HL-60 cells.	Quercetin	60-69	BCL2 apoptosis regulator	Homo sapiens	111-116
22555976-5	2012	Our results indicate that the apoptotic processes caused by quercetin are mediated by the decrease of pAkt and Bcl-2 levels, the increase of Bax level, and the activation of caspase families in HL-60 cells.	Quercetin	60-69	BCL2 associated X, apoptosis regulator	Homo sapiens	141-144
22555976-5	2012	Our results indicate that the apoptotic processes caused by quercetin are mediated by the decrease of pAkt and Bcl-2 levels, the increase of Bax level, and the activation of caspase families in HL-60 cells.	Quercetin	60-69	caspase 2	Homo sapiens	174-181
22445681-9	2012	By co-treatment with HSP inhibitors, quercetin or KNK437 potentiated BCSCs, which determined with ALDH+ population or mammosphere cells, toward GA inhibition, as well as anti-proliferation and anti-migration effects of GA. With siRNA mediated gene silencing, we found that knockdown of Hsp27 could mimic the effect of HSP inhibitors to potentiate the BCSC targeting effect of GA.	Quercetin	37-46	heat shock protein family B (small) member 1	Homo sapiens	286-291
22469840-0	2012	Quercetin acts as an antioxidant and downregulates CYP1A1 and CYP1B1             against DMBA-induced oxidative stress in mice.	Quercetin	0-9	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	51-57
22469840-0	2012	Quercetin acts as an antioxidant and downregulates CYP1A1 and CYP1B1             against DMBA-induced oxidative stress in mice.	Quercetin	0-9	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	62-68
22469840-3	2012	Quercetin showed side effects such as increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in DMBA-untreated mice.	Quercetin	0-9	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	48-74
22469840-3	2012	Quercetin showed side effects such as increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in DMBA-untreated mice.	Quercetin	0-9	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	76-79
22469840-3	2012	Quercetin showed side effects such as increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in DMBA-untreated mice.	Quercetin	0-9	glutamic pyruvic transaminase, soluble	Mus musculus	85-109
22469840-3	2012	Quercetin showed side effects such as increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in DMBA-untreated mice.	Quercetin	0-9	glutamic pyruvic transaminase, soluble	Mus musculus	111-114
22469840-4	2012	Also, quercetin induced AST and ALT in DMBA-treated, although this was not significantly different from levels in DMBA-treated controls.	Quercetin	6-15	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	24-27
22469840-4	2012	Also, quercetin induced AST and ALT in DMBA-treated, although this was not significantly different from levels in DMBA-treated controls.	Quercetin	6-15	glutamic pyruvic transaminase, soluble	Mus musculus	32-35
22469840-6	2012	Also, catalase and superoxide dismutase (SOD) activities as well as their mRNA expression were increased by quercetin; this increase was more pronounced in DMBA-treated compared to untreated mice.	Quercetin	108-117	catalase	Mus musculus	6-14
22469840-8	2012	Each of these effects was significantly reduced by quercetin; however, this reduction was observed for CYP1A1 at only the higher dose and for CYP1B1 at both doses.	Quercetin	51-60	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	103-109
22469840-8	2012	Each of these effects was significantly reduced by quercetin; however, this reduction was observed for CYP1A1 at only the higher dose and for CYP1B1 at both doses.	Quercetin	51-60	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	142-148
22469840-10	2012	Moreover, its regulation of CYP1A1 and CYP1B1 suggests the potential of quercetin as an anticancer supplement.	Quercetin	72-81	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	28-34
22469840-10	2012	Moreover, its regulation of CYP1A1 and CYP1B1 suggests the potential of quercetin as an anticancer supplement.	Quercetin	72-81	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	39-45
22700507-8	2012	To assess the specificity of Hsp90, we evaluated the efficacy of the flavonoid quercetin, an inhibitor of Hsp70 synthesis, in preventing TD development; it decreased Hsp70 levels but not those of Hsp90 in the control growth plates and prevented upregulation of Hsp70 in the TD-affected growth plates.	Quercetin	79-88	heat shock protein family A (Hsp70) member 4	Homo sapiens	106-111
22700507-8	2012	To assess the specificity of Hsp90, we evaluated the efficacy of the flavonoid quercetin, an inhibitor of Hsp70 synthesis, in preventing TD development; it decreased Hsp70 levels but not those of Hsp90 in the control growth plates and prevented upregulation of Hsp70 in the TD-affected growth plates.	Quercetin	79-88	heat shock protein family A (Hsp70) member 4	Homo sapiens	166-171
22700507-8	2012	To assess the specificity of Hsp90, we evaluated the efficacy of the flavonoid quercetin, an inhibitor of Hsp70 synthesis, in preventing TD development; it decreased Hsp70 levels but not those of Hsp90 in the control growth plates and prevented upregulation of Hsp70 in the TD-affected growth plates.	Quercetin	79-88	heat shock protein family A (Hsp70) member 4	Homo sapiens	166-171
22511755-6	2012	Quercetin, a potent WNT/beta-catenin inhibitor, suppressed uPAR and uPAR-mediated WNT/beta-catenin activation, and furthermore, addition of recombinant human WNT-7a protein induced uPAR, indicating the existence of a mutual regulatory relationship between uPAR and WNT/beta-catenin signaling.	Quercetin	0-9	catenin beta 1	Homo sapiens	24-36
22511755-6	2012	Quercetin, a potent WNT/beta-catenin inhibitor, suppressed uPAR and uPAR-mediated WNT/beta-catenin activation, and furthermore, addition of recombinant human WNT-7a protein induced uPAR, indicating the existence of a mutual regulatory relationship between uPAR and WNT/beta-catenin signaling.	Quercetin	0-9	plasminogen activator, urokinase receptor	Homo sapiens	59-63
22511755-6	2012	Quercetin, a potent WNT/beta-catenin inhibitor, suppressed uPAR and uPAR-mediated WNT/beta-catenin activation, and furthermore, addition of recombinant human WNT-7a protein induced uPAR, indicating the existence of a mutual regulatory relationship between uPAR and WNT/beta-catenin signaling.	Quercetin	0-9	plasminogen activator, urokinase receptor	Homo sapiens	68-72
22511755-6	2012	Quercetin, a potent WNT/beta-catenin inhibitor, suppressed uPAR and uPAR-mediated WNT/beta-catenin activation, and furthermore, addition of recombinant human WNT-7a protein induced uPAR, indicating the existence of a mutual regulatory relationship between uPAR and WNT/beta-catenin signaling.	Quercetin	0-9	catenin beta 1	Homo sapiens	86-98
22511755-6	2012	Quercetin, a potent WNT/beta-catenin inhibitor, suppressed uPAR and uPAR-mediated WNT/beta-catenin activation, and furthermore, addition of recombinant human WNT-7a protein induced uPAR, indicating the existence of a mutual regulatory relationship between uPAR and WNT/beta-catenin signaling.	Quercetin	0-9	Wnt family member 7A	Homo sapiens	158-164
22511755-6	2012	Quercetin, a potent WNT/beta-catenin inhibitor, suppressed uPAR and uPAR-mediated WNT/beta-catenin activation, and furthermore, addition of recombinant human WNT-7a protein induced uPAR, indicating the existence of a mutual regulatory relationship between uPAR and WNT/beta-catenin signaling.	Quercetin	0-9	plasminogen activator, urokinase receptor	Homo sapiens	68-72
22511755-6	2012	Quercetin, a potent WNT/beta-catenin inhibitor, suppressed uPAR and uPAR-mediated WNT/beta-catenin activation, and furthermore, addition of recombinant human WNT-7a protein induced uPAR, indicating the existence of a mutual regulatory relationship between uPAR and WNT/beta-catenin signaling.	Quercetin	0-9	plasminogen activator, urokinase receptor	Homo sapiens	68-72
22511755-6	2012	Quercetin, a potent WNT/beta-catenin inhibitor, suppressed uPAR and uPAR-mediated WNT/beta-catenin activation, and furthermore, addition of recombinant human WNT-7a protein induced uPAR, indicating the existence of a mutual regulatory relationship between uPAR and WNT/beta-catenin signaling.	Quercetin	0-9	catenin beta 1	Homo sapiens	86-98
21486423-6	2012	In contrast, quercetin significantly increased the GSH, CAT, GSH-Px and CuZn-SOD levels but decreased the formation of TBARS.	Quercetin	13-22	catalase	Rattus norvegicus	56-59
21486423-6	2012	In contrast, quercetin significantly increased the GSH, CAT, GSH-Px and CuZn-SOD levels but decreased the formation of TBARS.	Quercetin	13-22	superoxide dismutase 1	Rattus norvegicus	72-80
22258746-2	2012	Whereas CCoAOMT1 displays a strong preference for caffeoyl coenzyme A, COMT1 preferentially methylates 5-hydroxyferuloyl CoA derivatives and also performs methylation of flavonols with vicinal aromatic dihydroxy groups, such as quercetin.	Quercetin	228-237	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	8-16
22258746-2	2012	Whereas CCoAOMT1 displays a strong preference for caffeoyl coenzyme A, COMT1 preferentially methylates 5-hydroxyferuloyl CoA derivatives and also performs methylation of flavonols with vicinal aromatic dihydroxy groups, such as quercetin.	Quercetin	228-237	O-methyltransferase 1	Arabidopsis thaliana	71-76
22465313-4	2012	Pretreatment of airway epithelial cells with quercetin decreased Akt phosphosphorylation, viral endocytosis and IL-8 responses.	Quercetin	45-54	chemokine (C-X-C motif) ligand 15	Mus musculus	112-116
22492444-7	2012	To increase the production of quercetin 3-O-(6-deoxytalose) by increasing the supplement of dTDP-6-deoxytalose in E. coli, we engineered nucleotide biosynthetic genes of E. coli, such as galU (UTP-glucose 1-phosphate uridyltransferase), rffA (dTDP-4-oxo-6-deoxy-d-glucose transaminase), and/or rfbD (dTDP-4-dehydrorahmnose reductase).	Quercetin	30-39	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	92-96
22492444-7	2012	To increase the production of quercetin 3-O-(6-deoxytalose) by increasing the supplement of dTDP-6-deoxytalose in E. coli, we engineered nucleotide biosynthetic genes of E. coli, such as galU (UTP-glucose 1-phosphate uridyltransferase), rffA (dTDP-4-oxo-6-deoxy-d-glucose transaminase), and/or rfbD (dTDP-4-dehydrorahmnose reductase).	Quercetin	30-39	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	243-247
22492444-7	2012	To increase the production of quercetin 3-O-(6-deoxytalose) by increasing the supplement of dTDP-6-deoxytalose in E. coli, we engineered nucleotide biosynthetic genes of E. coli, such as galU (UTP-glucose 1-phosphate uridyltransferase), rffA (dTDP-4-oxo-6-deoxy-d-glucose transaminase), and/or rfbD (dTDP-4-dehydrorahmnose reductase).	Quercetin	30-39	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	243-247
21680781-0	2012	Effect of quercetin on CYP3A activity in Chinese healthy participants.	Quercetin	10-19	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	23-28
22438067-2	2012	We investigated whether quercetin, a natural inhibitor of catechol-O-methyltransferase (COMT) and multidrug resistance proteins (MRPs), will differentially increase the intracellular concentration and decrease the methylation of GTPs in different cancer cell lines.	Quercetin	24-33	catechol-O-methyltransferase	Homo sapiens	58-86
22438067-2	2012	We investigated whether quercetin, a natural inhibitor of catechol-O-methyltransferase (COMT) and multidrug resistance proteins (MRPs), will differentially increase the intracellular concentration and decrease the methylation of GTPs in different cancer cell lines.	Quercetin	24-33	catechol-O-methyltransferase	Homo sapiens	88-92
23118592-5	2012	At comparable conditions, quercetin was more potent in inhibiting MPO release than SO generation.	Quercetin	26-35	myeloperoxidase	Homo sapiens	66-69
21680781-1	2012	The aims of this study were to investigate the effect of quercetin on CYP3A activity in vivo.	Quercetin	57-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	70-75
21680781-9	2012	In conclusion, quercetin significantly induced CYP3A activity to substrate midazolam, and the induction was partly related to the CYP3A5 genotype, being more prominent in CYP3A5*1/*1 and CYP3A5*1/*3 individuals.	Quercetin	15-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	47-52
21680781-9	2012	In conclusion, quercetin significantly induced CYP3A activity to substrate midazolam, and the induction was partly related to the CYP3A5 genotype, being more prominent in CYP3A5*1/*1 and CYP3A5*1/*3 individuals.	Quercetin	15-24	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	130-136
21680781-9	2012	In conclusion, quercetin significantly induced CYP3A activity to substrate midazolam, and the induction was partly related to the CYP3A5 genotype, being more prominent in CYP3A5*1/*1 and CYP3A5*1/*3 individuals.	Quercetin	15-24	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	171-177
21680781-9	2012	In conclusion, quercetin significantly induced CYP3A activity to substrate midazolam, and the induction was partly related to the CYP3A5 genotype, being more prominent in CYP3A5*1/*1 and CYP3A5*1/*3 individuals.	Quercetin	15-24	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	171-177
22415355-0	2012	Neuroprotective effect of quercetin against hydrogen peroxide-induced oxidative injury in P19 neurons.	Quercetin	26-35	interleukin 23 subunit alpha	Homo sapiens	90-93
22812145-10	2012	CYP6AB5, CYP6B29, and GSTe8 were identified as inducible genes, of which the highest induction levels were 10.9-fold (0.5% quercetin for 7 d), 6.2-fold (1% quercetin for 7 d), and 7.1-fold (1% quercetin for 7 d), respectively.	Quercetin	123-132	cytochrome P450, family 6, subfamily ab, polypeptide 5	Bombyx mori	0-7
22812145-10	2012	CYP6AB5, CYP6B29, and GSTe8 were identified as inducible genes, of which the highest induction levels were 10.9-fold (0.5% quercetin for 7 d), 6.2-fold (1% quercetin for 7 d), and 7.1-fold (1% quercetin for 7 d), respectively.	Quercetin	123-132	cytochrome P450 Cyp6b29	Bombyx mori	9-16
22812145-10	2012	CYP6AB5, CYP6B29, and GSTe8 were identified as inducible genes, of which the highest induction levels were 10.9-fold (0.5% quercetin for 7 d), 6.2-fold (1% quercetin for 7 d), and 7.1-fold (1% quercetin for 7 d), respectively.	Quercetin	156-165	cytochrome P450, family 6, subfamily ab, polypeptide 5	Bombyx mori	0-7
22812145-10	2012	CYP6AB5, CYP6B29, and GSTe8 were identified as inducible genes, of which the highest induction levels were 10.9-fold (0.5% quercetin for 7 d), 6.2-fold (1% quercetin for 7 d), and 7.1-fold (1% quercetin for 7 d), respectively.	Quercetin	156-165	cytochrome P450 Cyp6b29	Bombyx mori	9-16
22812145-10	2012	CYP6AB5, CYP6B29, and GSTe8 were identified as inducible genes, of which the highest induction levels were 10.9-fold (0.5% quercetin for 7 d), 6.2-fold (1% quercetin for 7 d), and 7.1-fold (1% quercetin for 7 d), respectively.	Quercetin	156-165	cytochrome P450, family 6, subfamily ab, polypeptide 5	Bombyx mori	0-7
22812145-10	2012	CYP6AB5, CYP6B29, and GSTe8 were identified as inducible genes, of which the highest induction levels were 10.9-fold (0.5% quercetin for 7 d), 6.2-fold (1% quercetin for 7 d), and 7.1-fold (1% quercetin for 7 d), respectively.	Quercetin	156-165	cytochrome P450 Cyp6b29	Bombyx mori	9-16
22415355-3	2012	During the modest oxidative stress, quercetin diminished generation of reactive oxygen species (ROS) and prevented H(2)O(2)-induced nuclear condensation, increase in caspase 3/7 activity and rise in poly(APD-ribose) polymerase expression.	Quercetin	36-45	caspase 3	Homo sapiens	166-175
22524206-9	2012	DNA fragmentation, Bax/Bcl-2 ratio, nuclear translocation of apoptosis-inducing factor, as well as poly(adenosine diphosphate [ADP]-ribose) polymerase cleavage were significantly reduced by quercetin and sesamin administration, affirming their antiapoptotic features.	Quercetin	190-199	BCL2 associated X, apoptosis regulator	Rattus norvegicus	19-22
22447039-0	2012	Quercetin inhibits human breast cancer cell proliferation and induces             apoptosis via Bcl-2 and Bax regulation.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	96-101
22447039-0	2012	Quercetin inhibits human breast cancer cell proliferation and induces             apoptosis via Bcl-2 and Bax regulation.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
22447039-6	2012	Furthermore, following quercetin treatment Bcl-2 expression decreased significantly while Bax expression increased significantly (P&lt;0.05).	Quercetin	23-32	BCL2 apoptosis regulator	Homo sapiens	43-48
22447039-6	2012	Furthermore, following quercetin treatment Bcl-2 expression decreased significantly while Bax expression increased significantly (P&lt;0.05).	Quercetin	23-32	BCL2 associated X, apoptosis regulator	Homo sapiens	90-93
22808343-6	2012	High quercetin increased plasma adiponectin compared with the control group.	Quercetin	5-14	adiponectin, C1Q and collagen domain containing	Mus musculus	32-43
22808343-9	2012	Consumption of low and high quercetin reduced thiobarbituric acid reactive substances (TBARS) levels and elevated activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in the liver.	Quercetin	28-37	catalase	Mus musculus	156-164
22808343-9	2012	Consumption of low and high quercetin reduced thiobarbituric acid reactive substances (TBARS) levels and elevated activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in the liver.	Quercetin	28-37	catalase	Mus musculus	166-169
22524206-9	2012	DNA fragmentation, Bax/Bcl-2 ratio, nuclear translocation of apoptosis-inducing factor, as well as poly(adenosine diphosphate [ADP]-ribose) polymerase cleavage were significantly reduced by quercetin and sesamin administration, affirming their antiapoptotic features.	Quercetin	190-199	BCL2, apoptosis regulator	Rattus norvegicus	23-28
22387535-1	2012	Several protein tyrosine kinase (PTK) inhibitors predominantly isoflavones, such as genistein, erbstatin, quercetin, daidzein, present in red clover, cabbage and alfalfa, show apoptotic effect against cancer cells.	Quercetin	106-115	protein tyrosine kinase 2 beta	Homo sapiens	33-36
22943758-0	2012	[Effects of quercetin on nuclear factor-kappaB p65 expression in renal ubiquitin-proteasome system of diabetic rats].	Quercetin	12-21	synaptotagmin 1	Rattus norvegicus	47-50
22943758-19	2012	Quercetin has renal protective effects partly through reducing NF-kappaB p65 expression.	Quercetin	0-9	synaptotagmin 1	Rattus norvegicus	73-76
22350287-5	2012	Quercetin, epigallocatechin gallate and gallocatechin gallate (GCG) displayed good inhibition toward 3CL(pro) with IC(50) values of 73, 73 and 47 muM, respectively.	Quercetin	0-9	latexin	Homo sapiens	146-149
22394605-6	2012	Quercetin was the most potent inhibitor of the OATP1B1- and OATP1B3-mediated [3H]BSP transport with K(i)-values of 8.8+-0.8muM and 7.8+-1.7muM, respectively.	Quercetin	0-9	solute carrier organic anion transporter family member 1B1	Homo sapiens	47-54
22394605-6	2012	Quercetin was the most potent inhibitor of the OATP1B1- and OATP1B3-mediated [3H]BSP transport with K(i)-values of 8.8+-0.8muM and 7.8+-1.7muM, respectively.	Quercetin	0-9	solute carrier organic anion transporter family member 1B3	Homo sapiens	60-67
22114872-1	2012	AIM: To investigate the effect of quercetin on organic anion transporting polypeptide 1B1 (OATP1B1) activities in vitro and on the pharmacokinetics of pravastatin, a typical substrate for OATP1B1 in healthy Chinese-Han male subjects.	Quercetin	34-43	solute carrier organic anion transporter family member 1B1	Homo sapiens	47-89
22509835-0	2012	Quercetin enhancement of arsenic-induced apoptosis via stimulating ROS-dependent p53 protein ubiquitination in human HaCaT keratinocytes.	Quercetin	0-9	tumor protein p53	Homo sapiens	81-84
22114872-1	2012	AIM: To investigate the effect of quercetin on organic anion transporting polypeptide 1B1 (OATP1B1) activities in vitro and on the pharmacokinetics of pravastatin, a typical substrate for OATP1B1 in healthy Chinese-Han male subjects.	Quercetin	34-43	solute carrier organic anion transporter family member 1B1	Homo sapiens	91-98
22114872-2	2012	METHODS: Using human embryonic kidney 293 (HEK293) cells stably expressing OATP1B1, we observed the effect of quercetin on OATP1B1-mediated uptake of estrone-3-sulphate (E3S) and pravastatin.	Quercetin	110-119	solute carrier organic anion transporter family member 1B1	Homo sapiens	75-82
22114872-2	2012	METHODS: Using human embryonic kidney 293 (HEK293) cells stably expressing OATP1B1, we observed the effect of quercetin on OATP1B1-mediated uptake of estrone-3-sulphate (E3S) and pravastatin.	Quercetin	110-119	solute carrier organic anion transporter family member 1B1	Homo sapiens	123-130
22114872-4	2012	RESULTS: Quercetin competitively inhibited OATP1B1-mediated E3S uptake with a K(i) value of 17.9 +- 4.6 microm and also inhibited OATP1B1-mediated pravastatin uptake in a concentration dependent manner (IC(50) , 15.9 +- 1.4 microm).	Quercetin	9-18	solute carrier organic anion transporter family member 1B1	Homo sapiens	43-50
22114872-4	2012	RESULTS: Quercetin competitively inhibited OATP1B1-mediated E3S uptake with a K(i) value of 17.9 +- 4.6 microm and also inhibited OATP1B1-mediated pravastatin uptake in a concentration dependent manner (IC(50) , 15.9 +- 1.4 microm).	Quercetin	9-18	solute carrier organic anion transporter family member 1B1	Homo sapiens	130-137
22114872-8	2012	CONCLUSIONS: These findings suggest that quercetin inhibits the OATP1B1-mediated transport of E3S and pravastatin in vitro and also has a modest inhibitory influence on the pharmacokinetics of pravastatin in healthy Chinese-Han male volunteers.	Quercetin	41-50	solute carrier organic anion transporter family member 1B1	Homo sapiens	64-71
22114872-9	2012	The effects of quercetin on other OATP1B1 substrate drugs deserve further investigation.	Quercetin	15-24	solute carrier organic anion transporter family member 1B1	Homo sapiens	34-41
22459208-3	2012	It has been reported that the anti-diabetic drug metformin and some natural compounds, such as quercetin, genistein, capsaicin and green tea polyphenol epigallocatechin gallate (EGCG), can activate AMPK and inhibit cancer cell growth.	Quercetin	95-104	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	198-202
22394507-0	2012	Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration.	Quercetin	0-9	interleukin 6	Homo sapiens	20-24
22394507-0	2012	Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	25-30
22394507-5	2012	In this study, we show that quercetin is a potent inhibitor of the IL-6-induced STAT3 signaling pathway in T98G and U87 glioblastoma cells.	Quercetin	28-37	interleukin 6	Homo sapiens	67-71
22394507-5	2012	In this study, we show that quercetin is a potent inhibitor of the IL-6-induced STAT3 signaling pathway in T98G and U87 glioblastoma cells.	Quercetin	28-37	signal transducer and activator of transcription 3	Homo sapiens	80-85
22394507-6	2012	Exposure to quercetin resulted in the reduction of GP130, JAK1 and STAT3 activation by IL-6, as well as a marked decrease of the proliferative and migratory properties of glioblastoma cells induced by IL-6.	Quercetin	12-21	interleukin 6 cytokine family signal transducer	Homo sapiens	51-56
22394507-6	2012	Exposure to quercetin resulted in the reduction of GP130, JAK1 and STAT3 activation by IL-6, as well as a marked decrease of the proliferative and migratory properties of glioblastoma cells induced by IL-6.	Quercetin	12-21	Janus kinase 1	Homo sapiens	58-62
22394507-6	2012	Exposure to quercetin resulted in the reduction of GP130, JAK1 and STAT3 activation by IL-6, as well as a marked decrease of the proliferative and migratory properties of glioblastoma cells induced by IL-6.	Quercetin	12-21	signal transducer and activator of transcription 3	Homo sapiens	67-72
22394507-6	2012	Exposure to quercetin resulted in the reduction of GP130, JAK1 and STAT3 activation by IL-6, as well as a marked decrease of the proliferative and migratory properties of glioblastoma cells induced by IL-6.	Quercetin	12-21	interleukin 6	Homo sapiens	87-91
22394507-6	2012	Exposure to quercetin resulted in the reduction of GP130, JAK1 and STAT3 activation by IL-6, as well as a marked decrease of the proliferative and migratory properties of glioblastoma cells induced by IL-6.	Quercetin	12-21	interleukin 6	Homo sapiens	201-205
22394507-7	2012	Interestingly, quercetin also modulated the expression of two target genes regulated by STAT3, i.e. cyclin D1 and matrix metalloproteinase-2 (MMP-2).	Quercetin	15-24	signal transducer and activator of transcription 3	Homo sapiens	88-93
22394507-7	2012	Interestingly, quercetin also modulated the expression of two target genes regulated by STAT3, i.e. cyclin D1 and matrix metalloproteinase-2 (MMP-2).	Quercetin	15-24	cyclin D1	Homo sapiens	100-109
22394507-7	2012	Interestingly, quercetin also modulated the expression of two target genes regulated by STAT3, i.e. cyclin D1 and matrix metalloproteinase-2 (MMP-2).	Quercetin	15-24	matrix metallopeptidase 2	Homo sapiens	114-140
22394507-7	2012	Interestingly, quercetin also modulated the expression of two target genes regulated by STAT3, i.e. cyclin D1 and matrix metalloproteinase-2 (MMP-2).	Quercetin	15-24	matrix metallopeptidase 2	Homo sapiens	142-147
22394507-8	2012	Moreover, quercetin reduced the recruitment of STAT3 at the cyclin D1 promoter and inhibited Rb phosphorylation in the presence of IL-6.	Quercetin	10-19	signal transducer and activator of transcription 3	Homo sapiens	47-52
22394507-8	2012	Moreover, quercetin reduced the recruitment of STAT3 at the cyclin D1 promoter and inhibited Rb phosphorylation in the presence of IL-6.	Quercetin	10-19	cyclin D1	Homo sapiens	60-69
22394507-8	2012	Moreover, quercetin reduced the recruitment of STAT3 at the cyclin D1 promoter and inhibited Rb phosphorylation in the presence of IL-6.	Quercetin	10-19	interleukin 6	Homo sapiens	131-135
22310237-2	2012	It was found that both quercetin and QS can inhibit the growth of cancer cells in a dose-dependent manner, with the IC(50) values of 40.2 and 28.0 muM for LoVo cells and 30.8 and 19.9 muM for MCF-7 cells, respectively, suggesting QS was more effective against the cancer cells than quercetin.	Quercetin	23-32	latexin	Homo sapiens	147-150
22310237-2	2012	It was found that both quercetin and QS can inhibit the growth of cancer cells in a dose-dependent manner, with the IC(50) values of 40.2 and 28.0 muM for LoVo cells and 30.8 and 19.9 muM for MCF-7 cells, respectively, suggesting QS was more effective against the cancer cells than quercetin.	Quercetin	23-32	latexin	Homo sapiens	184-187
22394507-9	2012	Overall, these results provide new insight into the role of quercetin as a blocker of the STAT3 activation pathway stimulated by IL-6, with a potential role in the prevention and treatment of glioblastoma.	Quercetin	60-69	signal transducer and activator of transcription 3	Homo sapiens	90-95
22509835-8	2012	QUE plus As(+3) stimulation of apoptosis in human HaCaT keratinocytes via activating ROS-dependent p53 protein ubiquitination may offer a rationale for the use of QUE to improve the clinical efficacy of arsenics in treating psoriasis.	Quercetin	0-3	tumor protein p53	Homo sapiens	99-102
22394507-9	2012	Overall, these results provide new insight into the role of quercetin as a blocker of the STAT3 activation pathway stimulated by IL-6, with a potential role in the prevention and treatment of glioblastoma.	Quercetin	60-69	interleukin 6	Homo sapiens	129-133
22365892-5	2012	Furthermore, quercetin prophylaxis evidently ameliorated ethanol-stimulated mitochondrial dysfunction manifested by decreased membrane potential and induced permeability transition though suppressing glutathione depletion, enzymatic inactivation of manganese superoxide dismutase and glutathione peroxidase, ROS over-generation, and lipid peroxidation in mitochondria.	Quercetin	13-22	superoxide dismutase 2	Rattus norvegicus	249-279
22295890-0	2012	Quercetin and catechin synergistically inhibit angiotensin II-induced redox-dependent signalling pathways in vascular smooth muscle cells from hypertensive rats.	Quercetin	0-9	angiotensinogen	Rattus norvegicus	47-61
22295890-2	2012	The aim of this study was to explore the effect of quercetin (Q), catechin (C) and the mixture, on Angiotensin II (AngII)-induced redox-dependent signalling pathways and cell behaviour.	Quercetin	51-60	angiotensinogen	Rattus norvegicus	99-113
22295890-2	2012	The aim of this study was to explore the effect of quercetin (Q), catechin (C) and the mixture, on Angiotensin II (AngII)-induced redox-dependent signalling pathways and cell behaviour.	Quercetin	51-60	angiotensinogen	Rattus norvegicus	115-120
22465384-2	2012	In this study, the ability of quercetin to protect against CS-induced mucin expression was examined in vivo and in vitro.	Quercetin	30-39	solute carrier family 13 member 2	Rattus norvegicus	70-75
22465384-8	2012	In vivo, quercetin pretreatment suppressed CS-induced goblet cell hyperplasia, inflammation, oxidative stress, EGFR phosphorylation and NF-kappaB pathway activation in rat lung.	Quercetin	9-18	epidermal growth factor receptor	Rattus norvegicus	111-115
22465384-9	2012	In vitro, quercetin pretreatment attenuated the CSE-induced Muc5ac expression, NF-kappaB activation and EGFR phosphorylation.	Quercetin	10-19	mucin 5AC, oligomeric mucus/gel-forming	Rattus norvegicus	60-66
22465384-9	2012	In vitro, quercetin pretreatment attenuated the CSE-induced Muc5ac expression, NF-kappaB activation and EGFR phosphorylation.	Quercetin	10-19	epidermal growth factor receptor	Rattus norvegicus	104-108
22465384-10	2012	Our results suggest that quercetin attenuates CS-induced mucin protein synthesis in rat lung, possibly by inhibiting oxidative stress and inflammation via a mechanism involving NF-kappaB pathway activation and EGFR phosphorylation.	Quercetin	25-34	solute carrier family 13 member 2	Rattus norvegicus	57-62
22465384-10	2012	Our results suggest that quercetin attenuates CS-induced mucin protein synthesis in rat lung, possibly by inhibiting oxidative stress and inflammation via a mechanism involving NF-kappaB pathway activation and EGFR phosphorylation.	Quercetin	25-34	epidermal growth factor receptor	Rattus norvegicus	210-214
22174042-0	2012	Molecular mechanisms of early growth response protein-1 (EGR-1) expression by quercetin in INS-1 beta-cells.	Quercetin	78-87	early growth response 1	Rattus norvegicus	24-55
22174042-11	2012	Collectively, quercetin-induced EGR-1 expression is largely dependent on PKA and partly on p38 MAPK pathway, and SRE sites of EGR-1 promoter are involved in quercetin-induced EGR-1 transcriptional activity.	Quercetin	157-166	early growth response 1	Rattus norvegicus	126-131
21732360-0	2012	The pro-apoptotic effect of quercetin in cancer cell lines requires ERbeta-dependent signals.	Quercetin	28-37	estrogen receptor 2	Homo sapiens	68-74
21732360-3	2012	In a previous study, we demonstrated that quercetin elicited apoptosis through an ERalpha-dependent mechanism.	Quercetin	42-51	estrogen receptor 1	Homo sapiens	82-89
21732360-5	2012	Here, we report that quercetin, at nutritionally relevant concentrations, mimicked the 17beta-estradiol (E2)-induced apoptotic effect in both ERbeta1-transfected HeLa and in ERbeta1-containing DLD-1 colon cancer cell lines by inducing the activation of p38.	Quercetin	21-30	mitogen-activated protein kinase 1	Homo sapiens	253-256
21732360-8	2012	On the contrary, quercetin acted similarly to E2 by increasing the levels of the oncosuppressor protein PTEN and by impeding ERbeta-dependent cyclin D1 promoter activity, which subsequently resulted in the transcription of the estrogen-responsive element remaining unchanged.	Quercetin	17-26	phosphatase and tensin homolog	Homo sapiens	104-108
21732360-8	2012	On the contrary, quercetin acted similarly to E2 by increasing the levels of the oncosuppressor protein PTEN and by impeding ERbeta-dependent cyclin D1 promoter activity, which subsequently resulted in the transcription of the estrogen-responsive element remaining unchanged.	Quercetin	17-26	estrogen receptor 2	Homo sapiens	125-131
21732360-8	2012	On the contrary, quercetin acted similarly to E2 by increasing the levels of the oncosuppressor protein PTEN and by impeding ERbeta-dependent cyclin D1 promoter activity, which subsequently resulted in the transcription of the estrogen-responsive element remaining unchanged.	Quercetin	17-26	cyclin D1	Homo sapiens	142-151
21732360-10	2012	In addition, the quercetin pro-apoptotic action in the presence of ERalpha may render it as a dual-sided protective agent against E2-related cancer in the reduction of tumour growth in organs that express ERalpha and/or ERbeta.	Quercetin	17-26	estrogen receptor 1	Homo sapiens	67-74
21732360-10	2012	In addition, the quercetin pro-apoptotic action in the presence of ERalpha may render it as a dual-sided protective agent against E2-related cancer in the reduction of tumour growth in organs that express ERalpha and/or ERbeta.	Quercetin	17-26	estrogen receptor 1	Homo sapiens	205-212
21732360-10	2012	In addition, the quercetin pro-apoptotic action in the presence of ERalpha may render it as a dual-sided protective agent against E2-related cancer in the reduction of tumour growth in organs that express ERalpha and/or ERbeta.	Quercetin	17-26	estrogen receptor 2	Homo sapiens	220-226
22174042-11	2012	Collectively, quercetin-induced EGR-1 expression is largely dependent on PKA and partly on p38 MAPK pathway, and SRE sites of EGR-1 promoter are involved in quercetin-induced EGR-1 transcriptional activity.	Quercetin	157-166	early growth response 1	Rattus norvegicus	126-131
22174042-0	2012	Molecular mechanisms of early growth response protein-1 (EGR-1) expression by quercetin in INS-1 beta-cells.	Quercetin	78-87	early growth response 1	Rattus norvegicus	57-62
22174042-0	2012	Molecular mechanisms of early growth response protein-1 (EGR-1) expression by quercetin in INS-1 beta-cells.	Quercetin	78-87	insulin 1	Rattus norvegicus	91-96
22174042-2	2012	We recently reported that quercetin increased catalytic subunit of gamma-glutamylcysteine ligase (GCLC) via the interaction of EGR-1 to GCLC promoter in INS-1 beta-cells.	Quercetin	26-35	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	98-102
22174042-2	2012	We recently reported that quercetin increased catalytic subunit of gamma-glutamylcysteine ligase (GCLC) via the interaction of EGR-1 to GCLC promoter in INS-1 beta-cells.	Quercetin	26-35	early growth response 1	Rattus norvegicus	127-132
22174042-2	2012	We recently reported that quercetin increased catalytic subunit of gamma-glutamylcysteine ligase (GCLC) via the interaction of EGR-1 to GCLC promoter in INS-1 beta-cells.	Quercetin	26-35	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	136-140
22174042-2	2012	We recently reported that quercetin increased catalytic subunit of gamma-glutamylcysteine ligase (GCLC) via the interaction of EGR-1 to GCLC promoter in INS-1 beta-cells.	Quercetin	26-35	insulin 1	Rattus norvegicus	153-158
22174042-3	2012	Therefore, this study investigated molecular mechanisms of quercetin-induced EGR-1 expression in INS-1 cells.	Quercetin	59-68	early growth response 1	Rattus norvegicus	77-82
22174042-3	2012	Therefore, this study investigated molecular mechanisms of quercetin-induced EGR-1 expression in INS-1 cells.	Quercetin	59-68	insulin 1	Rattus norvegicus	97-102
22174042-4	2012	Quercetin significantly induced EGR-1 protein and its mRNA expressions.	Quercetin	0-9	early growth response 1	Rattus norvegicus	32-37
22174042-6	2012	Additionally, the siRNA-mediated inhibition of PKAalpha and p38 resulted in significant reduction of quercetin-induced EGR-1 promoter activity.	Quercetin	101-110	mitogen activated protein kinase 14	Rattus norvegicus	60-63
22174042-6	2012	Additionally, the siRNA-mediated inhibition of PKAalpha and p38 resulted in significant reduction of quercetin-induced EGR-1 promoter activity.	Quercetin	101-110	early growth response 1	Rattus norvegicus	119-124
22174042-7	2012	Also, quercetin-induced EGR-1 protein expression was significantly decreased in the cells transfected with PKAalpha siRNA.	Quercetin	6-15	early growth response 1	Rattus norvegicus	24-29
22174042-11	2012	Collectively, quercetin-induced EGR-1 expression is largely dependent on PKA and partly on p38 MAPK pathway, and SRE sites of EGR-1 promoter are involved in quercetin-induced EGR-1 transcriptional activity.	Quercetin	14-23	early growth response 1	Rattus norvegicus	32-37
22174042-11	2012	Collectively, quercetin-induced EGR-1 expression is largely dependent on PKA and partly on p38 MAPK pathway, and SRE sites of EGR-1 promoter are involved in quercetin-induced EGR-1 transcriptional activity.	Quercetin	14-23	mitogen activated protein kinase 14	Rattus norvegicus	91-94
22174042-11	2012	Collectively, quercetin-induced EGR-1 expression is largely dependent on PKA and partly on p38 MAPK pathway, and SRE sites of EGR-1 promoter are involved in quercetin-induced EGR-1 transcriptional activity.	Quercetin	14-23	early growth response 1	Rattus norvegicus	126-131
22174042-11	2012	Collectively, quercetin-induced EGR-1 expression is largely dependent on PKA and partly on p38 MAPK pathway, and SRE sites of EGR-1 promoter are involved in quercetin-induced EGR-1 transcriptional activity.	Quercetin	14-23	early growth response 1	Rattus norvegicus	126-131
22345440-5	2012	Hsp70 has been shown to interact with the nucleoprotein N. The downregulation of Hsp70, using specific chaperone inhibitors, such as quercetin or RNA interference, resulted in a significant decrease of the amount of viral mRNAs, viral proteins, and virus particles.	Quercetin	133-142	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
22345440-5	2012	Hsp70 has been shown to interact with the nucleoprotein N. The downregulation of Hsp70, using specific chaperone inhibitors, such as quercetin or RNA interference, resulted in a significant decrease of the amount of viral mRNAs, viral proteins, and virus particles.	Quercetin	133-142	heat shock protein family A (Hsp70) member 4	Homo sapiens	81-86
22307090-8	2012	Quercetin was the most potent inhibitor among the flavonoids examined in this study, and our data suggest that it should be examined for potential pharmacokinetic drug interactions pertaining to CYP2C8 substrates in vivo.	Quercetin	0-9	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	195-201
22117525-2	2012	At a concentration of 100 muM, 42 natural products inhibited OATP1B1-mediated [(3)H]E3S uptake by more than 50%, and five of them significantly inhibited OATP1B1-mediated [(3)H]E3S by more than 80% with the following rank order of potency: quercetin &gt; astragaloside IV &gt; icariin &gt; glycyrrhizic acid &gt; ginsenoside Rc.	Quercetin	240-249	solute carrier organic anion transporter family member 1B1	Homo sapiens	61-68
22402395-6	2012	We found lower mRNA steady state levels of the inflammatory genes interleukin 6, C-reactive protein, monocyte chemoattractant protein 1, and acyloxyacyl hydrolase in quercetin fed mice.	Quercetin	166-175	interleukin 6	Mus musculus	66-79
22402395-6	2012	We found lower mRNA steady state levels of the inflammatory genes interleukin 6, C-reactive protein, monocyte chemoattractant protein 1, and acyloxyacyl hydrolase in quercetin fed mice.	Quercetin	166-175	C-reactive protein, pentraxin-related	Mus musculus	81-99
22402395-6	2012	We found lower mRNA steady state levels of the inflammatory genes interleukin 6, C-reactive protein, monocyte chemoattractant protein 1, and acyloxyacyl hydrolase in quercetin fed mice.	Quercetin	166-175	chemokine (C-C motif) ligand 2	Mus musculus	101-135
22402395-6	2012	We found lower mRNA steady state levels of the inflammatory genes interleukin 6, C-reactive protein, monocyte chemoattractant protein 1, and acyloxyacyl hydrolase in quercetin fed mice.	Quercetin	166-175	acyloxyacyl hydrolase	Mus musculus	141-162
22402395-7	2012	In addition we found evidence for an involvement of redox factor 1, a modulator of nuclear factor kappaB signalling, on the attenuation of inflammatory gene expression mediated by dietary quercetin.	Quercetin	188-197	apurinic/apyrimidinic endonuclease 1	Mus musculus	52-66
22402395-8	2012	Furthermore, the results demonstrate that hepatic miR-122 and miR-125b concentrations were increased by dietary quercetin supplementation and may therefore contribute to the gene-regulatory activity of quercetin in vivo.	Quercetin	112-121	microRNA 122	Mus musculus	50-57
22402395-8	2012	Furthermore, the results demonstrate that hepatic miR-122 and miR-125b concentrations were increased by dietary quercetin supplementation and may therefore contribute to the gene-regulatory activity of quercetin in vivo.	Quercetin	202-211	microRNA 122	Mus musculus	50-57
22557973-6	2012	Protein kinase C (PKC) inhibition exerted by chelerythrine prior to quercetin attenuated quercetin-induced effects: order 2 arterioles dilated by 19.0 +- 2.4% baseline, while there was an increase in permeability (0.40 +- 0.05 NGL) and leukocyte adhesion with a marked decrease in capillary perfusion.	Quercetin	68-77	protein kinase C, gamma	Rattus norvegicus	18-21
22557973-6	2012	Protein kinase C (PKC) inhibition exerted by chelerythrine prior to quercetin attenuated quercetin-induced effects: order 2 arterioles dilated by 19.0 +- 2.4% baseline, while there was an increase in permeability (0.40 +- 0.05 NGL) and leukocyte adhesion with a marked decrease in capillary perfusion.	Quercetin	89-98	protein kinase C, gamma	Rattus norvegicus	18-21
22557973-10	2012	Finally, combined inhibition of PKC and TK prior to quercetin abolished quercetin-induced effects, decreasing eNOS expression, while blocking ATP-sensitive potassium (K(ATP)) channels by glibenclamide suppressed arteriolar dilation.	Quercetin	72-81	protein kinase C, gamma	Rattus norvegicus	32-35
22557973-11	2012	In conclusion, the protective effects of quercetin could be due to different mechanisms resulting in NO release throughout PKC and TK intracellular signaling pathway activation.	Quercetin	41-50	protein kinase C, gamma	Rattus norvegicus	123-126
22202969-0	2012	Quercetin treatment changes fluxes in the primary metabolism and increases culture longevity and recombinant alpha1-antitrypsin production in human AGE1.HN cells.	Quercetin	0-9	serpin family A member 1	Homo sapiens	109-127
22202969-1	2012	Addition of the flavonoid quercetin to cultivations of the alpha(1)-antitrypsin (A1AT) producing human AGE1.HN.AAT cell line resulted in alterations of the cellular physiology and a remarkable improvement of the overall performance of these cells.	Quercetin	26-35	serpin family A member 1	Homo sapiens	59-79
22202969-1	2012	Addition of the flavonoid quercetin to cultivations of the alpha(1)-antitrypsin (A1AT) producing human AGE1.HN.AAT cell line resulted in alterations of the cellular physiology and a remarkable improvement of the overall performance of these cells.	Quercetin	26-35	serpin family A member 1	Homo sapiens	81-85
21597316-6	2012	Furthermore, when hMSC were induced to differentiate into osteoblasts, all the above-mentioned molecules and also quercetin, another phytoestrogen, significantly reverted the inhibitory effect of RGZ on the expression of the osteogenic marker osteocalcin and decreased the number of fat cells observed after RGZ exposure.	Quercetin	114-123	musculin	Homo sapiens	18-22
22127757-5	2012	Quercetin, a free radical scavenger decreased the levels of oxidative stress markers in the hippocampus of simultaneous PCB+quercetin treated rats.	Quercetin	0-9	pyruvate carboxylase	Rattus norvegicus	120-123
22257724-0	2012	The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat.	Quercetin	16-25	matrix metallopeptidase 9	Rattus norvegicus	61-66
22487368-5	2012	Quercetin, one of the active components in Calendula, has been shown to inhibit recombinant human matrix metalloproteinase (MMP) activity and decrease the expression of tumor necrosis factor-alpha, interleukin-1beta (IL), IL-6 and IL-8 in phorbol 12-myristate 13-acetate and calcium ionophore-stimulated human mast cells.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	169-196
22487368-5	2012	Quercetin, one of the active components in Calendula, has been shown to inhibit recombinant human matrix metalloproteinase (MMP) activity and decrease the expression of tumor necrosis factor-alpha, interleukin-1beta (IL), IL-6 and IL-8 in phorbol 12-myristate 13-acetate and calcium ionophore-stimulated human mast cells.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	198-215
22487368-5	2012	Quercetin, one of the active components in Calendula, has been shown to inhibit recombinant human matrix metalloproteinase (MMP) activity and decrease the expression of tumor necrosis factor-alpha, interleukin-1beta (IL), IL-6 and IL-8 in phorbol 12-myristate 13-acetate and calcium ionophore-stimulated human mast cells.	Quercetin	0-9	interleukin 6	Homo sapiens	222-226
22487368-5	2012	Quercetin, one of the active components in Calendula, has been shown to inhibit recombinant human matrix metalloproteinase (MMP) activity and decrease the expression of tumor necrosis factor-alpha, interleukin-1beta (IL), IL-6 and IL-8 in phorbol 12-myristate 13-acetate and calcium ionophore-stimulated human mast cells.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	231-235
22487368-13	2012	Quercetin inhibited HGF-mediated collagen degradation at 0.005, 0.01 and 0.02%, and MMP-2 activity in a dose-dependent manner.	Quercetin	0-9	hepatocyte growth factor	Homo sapiens	20-23
27081923-5	2012	It was found that the VHH-mediated reduction in mitochondrial membrane potential was suppressed in cells that had a 6 h post-heat shock recovery, and the protective effect of heat shock-induced HSP70 was attenuated following treatment of cells with the HSP70 inhibitor, quercetin.	Quercetin	270-279	heat shock protein family A (Hsp70) member 4	Homo sapiens	194-199
27081923-5	2012	It was found that the VHH-mediated reduction in mitochondrial membrane potential was suppressed in cells that had a 6 h post-heat shock recovery, and the protective effect of heat shock-induced HSP70 was attenuated following treatment of cells with the HSP70 inhibitor, quercetin.	Quercetin	270-279	heat shock protein family A (Hsp70) member 4	Homo sapiens	253-258
22117525-2	2012	At a concentration of 100 muM, 42 natural products inhibited OATP1B1-mediated [(3)H]E3S uptake by more than 50%, and five of them significantly inhibited OATP1B1-mediated [(3)H]E3S by more than 80% with the following rank order of potency: quercetin &gt; astragaloside IV &gt; icariin &gt; glycyrrhizic acid &gt; ginsenoside Rc.	Quercetin	240-249	solute carrier organic anion transporter family member 1B1	Homo sapiens	154-161
22209726-4	2012	In the catechin-plus-chlorpyrifos and quercetin-plus-chlorpyrifos groups, there were statistically significantly decreased MDA levels, SOD and CAT activities, while increased GPx and GST activities compared with the chlorpyrifos-only group.	Quercetin	38-47	catalase	Rattus norvegicus	143-146
22421793-18	2012	Other known strong inhibitors, such as lopinavir, oltipraz, quercetin, raloxifene, and troglitazone, were among 18 compounds classified as plausible potent inhibitors of CYP3A4.	Quercetin	60-69	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	170-176
22613008-5	2012	Upon in vitro stimulation with quercetin, low susceptible cancer cells increased NKG2D ligand expression, leading to enhancement of NK cell cytolytic activity.	Quercetin	31-40	killer cell lectin like receptor K1	Homo sapiens	81-86
21932938-0	2012	The effect of quercetin on expression of SOX9 and subsequent release of type II collagen in spheno-occipital synchondroses of organ-cultured mice.	Quercetin	14-23	SRY (sex determining region Y)-box 9	Mus musculus	41-45
21932938-1	2012	OBJECTIVE: To identify the expressions of SOX9 and type II collagen in spheno-occipital synchondrosis in response to quercetin, using a mouse in vitro model.	Quercetin	117-126	SRY (sex determining region Y)-box 9	Mus musculus	42-46
21932938-9	2012	CONCLUSION: The expressions of SOX9 and type II collagen in the spheno-occipital synchondrosis can be increased by quercetin.	Quercetin	115-124	SRY (sex determining region Y)-box 9	Mus musculus	31-35
22159735-2	2012	The Arabidopsis enzyme AtUGT78D2 prefers UDP-glucose as a sugar donor and quercetin as a sugar acceptor.	Quercetin	74-83	UDP-glucosyl transferase 78D2	Arabidopsis thaliana	23-32
22159735-3	2012	However, in vitro, AtUGT78D2 could use UDP-N-acetylglucosamine as a sugar donor, and whole cell biotransformation of quercetin using E. coli harboring AtUGT78D2 produced quercetin 3-O-N-acetylglucosamine.	Quercetin	117-126	UDP-glucosyl transferase 78D2	Arabidopsis thaliana	151-160
22300659-6	2012	Counter screening, where the ability of these chosen flavonols to inhibit caspase 8 binding to itself was assessed, demonstrated that myricetin, morin and quercetin inhibited GST-E6 and His-caspase 8 binding in a specific manner.	Quercetin	155-164	caspase 8	Homo sapiens	74-83
22300659-6	2012	Counter screening, where the ability of these chosen flavonols to inhibit caspase 8 binding to itself was assessed, demonstrated that myricetin, morin and quercetin inhibited GST-E6 and His-caspase 8 binding in a specific manner.	Quercetin	155-164	caspase 8	Homo sapiens	190-199
22042611-5	2012	In this study, we tested the effects of quercetin, a bioflavonoid with anti-inflammatory properties, on AA development and HSP70 expression in the C3H/HeJ model.	Quercetin	40-49	heat shock protein 1B	Mus musculus	123-128
22042611-10	2012	As expected, the level of HSP70 expression in quercetin-treated areas was comparable to control.	Quercetin	46-55	heat shock protein 1B	Mus musculus	26-31
22209726-4	2012	In the catechin-plus-chlorpyrifos and quercetin-plus-chlorpyrifos groups, there were statistically significantly decreased MDA levels, SOD and CAT activities, while increased GPx and GST activities compared with the chlorpyrifos-only group.	Quercetin	38-47	hematopoietic prostaglandin D synthase	Rattus norvegicus	183-186
21674185-3	2012	We investigated the hypothesis that quercetin could prevent the ethanol-induced oxidative stress and decreases tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma) as pro-inflammatory cytokines.	Quercetin	36-45	tumor necrosis factor	Rattus norvegicus	111-138
21498475-4	2012	17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) and quercetin were used to inhibit the activity of HSP90 and HSP70.	Quercetin	66-75	heat shock protein 90 alpha family class A member 1	Homo sapiens	113-118
21498475-4	2012	17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) and quercetin were used to inhibit the activity of HSP90 and HSP70.	Quercetin	66-75	heat shock protein family A (Hsp70) member 4	Homo sapiens	123-128
21498475-8	2012	The co-inhibition of HSP70/HSP90 with quercetin plus 17-DMAG significantly increased apoptosis in hyperthermia-treated HNE1 cells both in vitro and in vivo.	Quercetin	38-47	heat shock protein family A (Hsp70) member 4	Homo sapiens	21-26
21498475-8	2012	The co-inhibition of HSP70/HSP90 with quercetin plus 17-DMAG significantly increased apoptosis in hyperthermia-treated HNE1 cells both in vitro and in vivo.	Quercetin	38-47	heat shock protein 90 alpha family class A member 1	Homo sapiens	27-32
23554737-7	2012	Quercetin caused a significant reduction both in the mPAP and right ventricular hypertrophy index compared with the monocrotaline group (P &lt; 0.01) while no difference was found between the quercetin group and the control group (P &gt; 0.05).	Quercetin	0-9	phospholipid phosphatase 1	Mus musculus	53-57
23554737-11	2012	Furthermore, compared with controls, proliferating cell nuclear antigen (PCNA) expression in the pulmonary artery tissues was markedly increased by monocrotaline [(45.59+-1.27) in monocrotaline vs. (9.64+-0.69) in controls], which was significantly attenuated by quercetin.	Quercetin	263-272	proliferating cell nuclear antigen	Rattus norvegicus	37-71
23554737-11	2012	Furthermore, compared with controls, proliferating cell nuclear antigen (PCNA) expression in the pulmonary artery tissues was markedly increased by monocrotaline [(45.59+-1.27) in monocrotaline vs. (9.64+-0.69) in controls], which was significantly attenuated by quercetin.	Quercetin	263-272	proliferating cell nuclear antigen	Rattus norvegicus	73-77
21674185-11	2012	Our results demonstrate that quercetin treatment may provide a protection as reflected by decreased plasma TBARS, protein carbonyls, TNF-alpha, INF-gamma and ALT levels against ethanol-induced oxidative damage.	Quercetin	29-38	tumor necrosis factor	Rattus norvegicus	133-142
21674185-3	2012	We investigated the hypothesis that quercetin could prevent the ethanol-induced oxidative stress and decreases tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma) as pro-inflammatory cytokines.	Quercetin	36-45	tumor necrosis factor	Rattus norvegicus	140-149
21674185-3	2012	We investigated the hypothesis that quercetin could prevent the ethanol-induced oxidative stress and decreases tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma) as pro-inflammatory cytokines.	Quercetin	36-45	interferon gamma	Rattus norvegicus	155-182
22145946-0	2012	Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling.	Quercetin	0-9	endothelin 1	Rattus norvegicus	158-170
22245592-2	2012	In this study, we investigated the role of SIRT1 signaling in the hypoxic down-regulations of c-Myc and beta-catenin and hypoxic preconditioning effect of the red wine polyphenols such as piceatannol, myricetin, quercetin and resveratrol.	Quercetin	212-221	sirtuin 1	Homo sapiens	43-48
22245592-6	2012	We also found that myricetin, quercetin, piceatannol and resveratrol up-regulated HIF-1alpha and down-regulated c-Myc, PHD2 and beta-catenin expressions via SIRT1 activation, in a manner that mimics hypoxic preconditioning.	Quercetin	30-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
22245592-6	2012	We also found that myricetin, quercetin, piceatannol and resveratrol up-regulated HIF-1alpha and down-regulated c-Myc, PHD2 and beta-catenin expressions via SIRT1 activation, in a manner that mimics hypoxic preconditioning.	Quercetin	30-39	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	112-117
22245592-6	2012	We also found that myricetin, quercetin, piceatannol and resveratrol up-regulated HIF-1alpha and down-regulated c-Myc, PHD2 and beta-catenin expressions via SIRT1 activation, in a manner that mimics hypoxic preconditioning.	Quercetin	30-39	egl-9 family hypoxia inducible factor 1	Homo sapiens	119-123
22245592-6	2012	We also found that myricetin, quercetin, piceatannol and resveratrol up-regulated HIF-1alpha and down-regulated c-Myc, PHD2 and beta-catenin expressions via SIRT1 activation, in a manner that mimics hypoxic preconditioning.	Quercetin	30-39	catenin beta 1	Homo sapiens	128-140
22245592-6	2012	We also found that myricetin, quercetin, piceatannol and resveratrol up-regulated HIF-1alpha and down-regulated c-Myc, PHD2 and beta-catenin expressions via SIRT1 activation, in a manner that mimics hypoxic preconditioning.	Quercetin	30-39	sirtuin 1	Homo sapiens	157-162
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	Quercetin	49-58	caspase 2	Homo sapiens	169-185
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	Quercetin	49-58	caspase 2	Homo sapiens	169-178
22969877-9	2012	Histological results, the number of apoptotic and p53-positive cells, NF-kappaB and eNOS expression levels were significantly decreased in the quercetin treatment group compared to the I/R group.	Quercetin	143-152	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	50-53
22222411-10	2012	A decrease in Bcl-2/Bax ratio with the increased expression of caspase-3 provides evidence that quercetin-induced apoptosis may be mediated via the mitochondrial pathway.	Quercetin	96-105	BCL2 apoptosis regulator	Homo sapiens	14-19
22222411-10	2012	A decrease in Bcl-2/Bax ratio with the increased expression of caspase-3 provides evidence that quercetin-induced apoptosis may be mediated via the mitochondrial pathway.	Quercetin	96-105	BCL2 associated X, apoptosis regulator	Homo sapiens	20-23
22222411-10	2012	A decrease in Bcl-2/Bax ratio with the increased expression of caspase-3 provides evidence that quercetin-induced apoptosis may be mediated via the mitochondrial pathway.	Quercetin	96-105	caspase 3	Homo sapiens	63-72
22145946-4	2012	Interestingly, the rats treated with quercetin showed significant suppression of the myocardial endothelin-1 and also the mitogen activated protein kinases (MAPK) suggesting that the protection offered by quercetin treatment against progression of EAM involves the modulation of MAPK signalling cascade.	Quercetin	37-46	endothelin 1	Rattus norvegicus	96-108
22145946-4	2012	Interestingly, the rats treated with quercetin showed significant suppression of the myocardial endothelin-1 and also the mitogen activated protein kinases (MAPK) suggesting that the protection offered by quercetin treatment against progression of EAM involves the modulation of MAPK signalling cascade.	Quercetin	205-214	endothelin 1	Rattus norvegicus	96-108
22172500-5	2012	These results suggest that the antioxidant activity of quercetin may be dependent on its ability to shuttle labile iron from cell compartments followed by its transfer to transferrin.	Quercetin	55-64	transferrin	Homo sapiens	171-182
21239456-3	2012	Here, we demonstrate that catechin and quercetin have the potential to down-regulate the initial signalling molecule NF-kappaB which may further inhibit the downstream cascade including TNF-alpha and NO.	Quercetin	39-48	tumor necrosis factor	Rattus norvegicus	186-195
22056766-0	2012	Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage.	Quercetin	49-58	heme oxygenase 1	Rattus norvegicus	0-16
21419610-5	2012	When the exposure of explants to curcumin or quercetin was limited to the first 4-5 days of culture, the suppression of 35S-aggrecan loss was maintained in the extended culture period when the tissue was stimulated with either retinoic acid or IL-1alpha.	Quercetin	45-54	interleukin 1 alpha	Bos taurus	244-253
21419610-6	2012	Quercetin suppressed IL-1alpha-stimulated expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4.	Quercetin	0-9	interleukin 1 alpha	Bos taurus	21-30
21419610-6	2012	Quercetin suppressed IL-1alpha-stimulated expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4.	Quercetin	0-9	ADAM metallopeptidase with thrombospondin type 1 motif 4	Bos taurus	97-129
21419610-8	2012	The ability of curcumin and quercetin to protect cartilage from stimulated aggrecan loss and to maintain this protection posttreatment may, at least in part, be due to the suppression of gene expression of ADAMTS-4 and -5.	Quercetin	28-37	ADAM metallopeptidase with thrombospondin type 1 motif 4	Bos taurus	206-221
22239530-0	2012	Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity.	Quercetin	50-59	KRAS proto-oncogene, GTPase	Homo sapiens	89-92
22239530-8	2012	The inhibitory effect of quercetin was also obtained when using a model system in which NS3 engineered substrates were introduced in NS3-expressing cells, providing evidence that inhibition in vivo could be directed to the NS3 and do not involve other HCV proteins.	Quercetin	25-34	KRAS proto-oncogene, GTPase	Homo sapiens	88-91
22239530-8	2012	The inhibitory effect of quercetin was also obtained when using a model system in which NS3 engineered substrates were introduced in NS3-expressing cells, providing evidence that inhibition in vivo could be directed to the NS3 and do not involve other HCV proteins.	Quercetin	25-34	KRAS proto-oncogene, GTPase	Homo sapiens	133-136
22239530-8	2012	The inhibitory effect of quercetin was also obtained when using a model system in which NS3 engineered substrates were introduced in NS3-expressing cells, providing evidence that inhibition in vivo could be directed to the NS3 and do not involve other HCV proteins.	Quercetin	25-34	KRAS proto-oncogene, GTPase	Homo sapiens	133-136
22239530-9	2012	Our work demonstrates that quercetin has a direct inhibitory effect on the HCV NS3 protease.	Quercetin	27-36	KRAS proto-oncogene, GTPase	Homo sapiens	79-82
22239530-10	2012	These results point to the potential of quercetin as a natural nontoxic anti-HCV agent reducing viral production by inhibiting both NS3 and heat shock proteins essential for HCV replication.	Quercetin	40-49	KRAS proto-oncogene, GTPase	Homo sapiens	132-135
22056766-8	2012	In summary, these data suggested that quercetin attenuates ethanol-induced oxidative stress through a pathway which involves ERK activation and HO-1 upregulation.	Quercetin	38-47	Eph receptor B1	Rattus norvegicus	125-128
22138401-0	2012	Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells.	Quercetin	0-9	heme oxygenase 1	Mus musculus	56-72
22197970-0	2012	Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
22197970-0	2012	Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	89-92
22197970-2	2012	This study investigated the influence of quercetin on p38-MAPK and the potential regulation of the nuclear transcription factor erythroid-2p45-related factor (Nrf2) and the cellular antioxidant/detoxifying defense system related to glutathione (GSH) by p38 in HepG2 cells.	Quercetin	41-50	mitogen-activated protein kinase 14	Homo sapiens	54-57
22197970-3	2012	Incubation of HepG2 cells with quercetin at a range of concentrations (5-50muM) for 4 or 18h induced a differential effect on the modulation of p38 and Nrf2 in HepG2 cells, 50muM quercetin showed the highest activation of p38 at 4h of treatment and values of p38 similar to those of control cells after 18 h of incubation, together with the inhibition of Nrf2 at both incubation times.	Quercetin	31-40	mitogen-activated protein kinase 14	Homo sapiens	144-147
22197970-3	2012	Incubation of HepG2 cells with quercetin at a range of concentrations (5-50muM) for 4 or 18h induced a differential effect on the modulation of p38 and Nrf2 in HepG2 cells, 50muM quercetin showed the highest activation of p38 at 4h of treatment and values of p38 similar to those of control cells after 18 h of incubation, together with the inhibition of Nrf2 at both incubation times.	Quercetin	31-40	NFE2 like bZIP transcription factor 2	Homo sapiens	152-156
22197970-3	2012	Incubation of HepG2 cells with quercetin at a range of concentrations (5-50muM) for 4 or 18h induced a differential effect on the modulation of p38 and Nrf2 in HepG2 cells, 50muM quercetin showed the highest activation of p38 at 4h of treatment and values of p38 similar to those of control cells after 18 h of incubation, together with the inhibition of Nrf2 at both incubation times.	Quercetin	31-40	mitogen-activated protein kinase 14	Homo sapiens	222-225
22197970-3	2012	Incubation of HepG2 cells with quercetin at a range of concentrations (5-50muM) for 4 or 18h induced a differential effect on the modulation of p38 and Nrf2 in HepG2 cells, 50muM quercetin showed the highest activation of p38 at 4h of treatment and values of p38 similar to those of control cells after 18 h of incubation, together with the inhibition of Nrf2 at both incubation times.	Quercetin	31-40	mitogen-activated protein kinase 14	Homo sapiens	222-225
22197970-3	2012	Incubation of HepG2 cells with quercetin at a range of concentrations (5-50muM) for 4 or 18h induced a differential effect on the modulation of p38 and Nrf2 in HepG2 cells, 50muM quercetin showed the highest activation of p38 at 4h of treatment and values of p38 similar to those of control cells after 18 h of incubation, together with the inhibition of Nrf2 at both incubation times.	Quercetin	31-40	NFE2 like bZIP transcription factor 2	Homo sapiens	355-359
22197970-3	2012	Incubation of HepG2 cells with quercetin at a range of concentrations (5-50muM) for 4 or 18h induced a differential effect on the modulation of p38 and Nrf2 in HepG2 cells, 50muM quercetin showed the highest activation of p38 at 4h of treatment and values of p38 similar to those of control cells after 18 h of incubation, together with the inhibition of Nrf2 at both incubation times.	Quercetin	179-188	mitogen-activated protein kinase 14	Homo sapiens	144-147
22197970-4	2012	Quercetin (50muM) induced a time-dependent activation of p38, which was in concert with a transient stimulation of Nrf2 to provoke its inhibition afterward.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	57-60
22197970-4	2012	Quercetin (50muM) induced a time-dependent activation of p38, which was in concert with a transient stimulation of Nrf2 to provoke its inhibition afterward.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
22197970-5	2012	Quercetin also increased GSH content, mRNA levels of glutamylcysteine-synthetase (GCS) and expression and/or activity of glutathione-peroxidase, glutathione-reductase and GCS after 4h of incubation, and glutathione-S-transferase after 18h of exposure.	Quercetin	0-9	glutathione-disulfide reductase	Homo sapiens	145-166
22197970-7	2012	In conclusion, p38-MAPK is involved in the mechanisms of the cell response to quercetin through the modulation of Nrf2 and glutathione-related enzymes in HepG2 cells.	Quercetin	78-87	mitogen-activated protein kinase 14	Homo sapiens	15-18
22197970-7	2012	In conclusion, p38-MAPK is involved in the mechanisms of the cell response to quercetin through the modulation of Nrf2 and glutathione-related enzymes in HepG2 cells.	Quercetin	78-87	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
22127324-9	2012	Quercetin increased superoxide dismutase, catalase, glutathione peroxidase activities, glutathione levels, and it decreased malondialdehyde levels in serum.	Quercetin	0-9	catalase	Rattus norvegicus	42-50
22138401-3	2012	In the present study, we showed that quercetin increased the levels of heme oxygenase (HO)-1 expression and protected against hydrogen peroxide (H(2)O(2))-induced cytotoxicity in lung epithelial cell lines.	Quercetin	37-46	heme oxygenase 1	Mus musculus	71-92
22138401-4	2012	Quercetin suppressed H(2)O(2)-induced apoptotic events, including hypodiploid cells, activation of caspase 3 enzyme activity and lactate dehydrogenase release.	Quercetin	0-9	caspase 3	Mus musculus	99-108
21856292-5	2012	However, it appears relatively easy to increase total quercetin concentrations in plasma (&gt;10 muM) by supplementation with quercetin-enriched foods or supplements.	Quercetin	54-63	latexin	Homo sapiens	97-100
22213289-6	2012	In p53-null cells, the combination of low dose 5-FU with up to 6 muM quercetin promoted clonogenic survival.	Quercetin	69-78	tumor protein p53	Homo sapiens	3-6
22213289-6	2012	In p53-null cells, the combination of low dose 5-FU with up to 6 muM quercetin promoted clonogenic survival.	Quercetin	69-78	latexin	Homo sapiens	65-68
22213289-7	2012	Treatment of p53-wild-type cells with 50 muM quercetin reduced drug-induced up-regulation of p53, p21 and BAX.	Quercetin	45-54	tumor protein p53	Homo sapiens	13-16
22213289-7	2012	Treatment of p53-wild-type cells with 50 muM quercetin reduced drug-induced up-regulation of p53, p21 and BAX.	Quercetin	45-54	latexin	Homo sapiens	41-44
22213289-7	2012	Treatment of p53-wild-type cells with 50 muM quercetin reduced drug-induced up-regulation of p53, p21 and BAX.	Quercetin	45-54	tumor protein p53	Homo sapiens	93-96
22213289-7	2012	Treatment of p53-wild-type cells with 50 muM quercetin reduced drug-induced up-regulation of p53, p21 and BAX.	Quercetin	45-54	H3 histone pseudogene 16	Homo sapiens	98-101
22213289-7	2012	Treatment of p53-wild-type cells with 50 muM quercetin reduced drug-induced up-regulation of p53, p21 and BAX.	Quercetin	45-54	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
22213289-8	2012	The combination of quercetin and the drugs also reduced the levels of cyclin B1 and survivin proteins.	Quercetin	19-28	cyclin B1	Homo sapiens	70-79
22213289-9	2012	CONCLUSION: While high doses of quercetin synergize with DNA-damaging agents, the effect of drug combination with quercetin is influenced by the effective doses and the p53 status of the cells.	Quercetin	114-123	tumor protein p53	Homo sapiens	169-172
21856292-5	2012	However, it appears relatively easy to increase total quercetin concentrations in plasma (&gt;10 muM) by supplementation with quercetin-enriched foods or supplements.	Quercetin	126-135	latexin	Homo sapiens	97-100
22971648-5	2012	Additionally, hyperin and quercetin suppressed total RS, ONOO(-), ( )O(2), and NO( ), catalase activity, and melanin synthesis, while they boosted the GSH/GSSG ratio in B16F10 melanoma cells (B16 cells).	Quercetin	26-35	catalase	Mus musculus	86-94
22829723-12	2012	The docking of quercetin with CB1 receptor showed a binding energy of -6.56 Kcal/mol with 4 hydrogen bonds, in comparison to the known drug Rimonabant.	Quercetin	15-24	cannabinoid receptor 1	Homo sapiens	30-33
22829723-13	2012	This data finds application in proposing antagonism of CB1 receptor with Quercetin, for controlling obesity.	Quercetin	73-82	cannabinoid receptor 1	Homo sapiens	55-58
23304202-10	2012	Quercetin dose dependently suppressed collagen, thrombin, or ADP-induced platelet aggregation.	Quercetin	0-9	coagulation factor II, thrombin	Homo sapiens	48-56
21951556-1	2012	We have previously shown that inhibition of intracellular signaling pathways by treatment with quercetin induced the expression of natural killer cell group 2D (NKG2D) ligands on cancer cells and made the cells sensitive to natural killer (NK)-cell mediated cytotoxicity.	Quercetin	95-104	killer cell lectin like receptor K1	Homo sapiens	131-159
21951556-1	2012	We have previously shown that inhibition of intracellular signaling pathways by treatment with quercetin induced the expression of natural killer cell group 2D (NKG2D) ligands on cancer cells and made the cells sensitive to natural killer (NK)-cell mediated cytotoxicity.	Quercetin	95-104	killer cell lectin like receptor K1	Homo sapiens	161-166
22759961-11	2012	Quercetin inhibited mRNA expressions of osteoclast-related genes and protein levels of RANK, TRAF6 and COX-2 in LPS-induced mature osteoclasts.	Quercetin	0-9	TNF receptor-associated factor 6	Mus musculus	93-98
22759961-11	2012	Quercetin inhibited mRNA expressions of osteoclast-related genes and protein levels of RANK, TRAF6 and COX-2 in LPS-induced mature osteoclasts.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	103-108
22759961-13	2012	Furthermore, quercetin promoted the apoptotic signaling pathway including increasing the phosphorylation of p38-MAPK, c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK), and Bax, while inhibited Bcl-2 expression.	Quercetin	13-22	mitogen-activated protein kinase 14	Mus musculus	108-111
22759961-13	2012	Furthermore, quercetin promoted the apoptotic signaling pathway including increasing the phosphorylation of p38-MAPK, c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK), and Bax, while inhibited Bcl-2 expression.	Quercetin	13-22	mitogen-activated protein kinase 8	Mus musculus	177-185
22759961-13	2012	Furthermore, quercetin promoted the apoptotic signaling pathway including increasing the phosphorylation of p38-MAPK, c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK), and Bax, while inhibited Bcl-2 expression.	Quercetin	13-22	BCL2-associated X protein	Mus musculus	192-195
22759961-13	2012	Furthermore, quercetin promoted the apoptotic signaling pathway including increasing the phosphorylation of p38-MAPK, c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK), and Bax, while inhibited Bcl-2 expression.	Quercetin	13-22	B cell leukemia/lymphoma 2	Mus musculus	213-218
22284780-11	2012	Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6.	Quercetin	83-92	nuclear factor kappa B subunit 1	Homo sapiens	114-123
22284780-11	2012	Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6.	Quercetin	83-92	nuclear factor kappa B subunit 1	Homo sapiens	125-134
22284780-11	2012	Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6.	Quercetin	83-92	tumor necrosis factor	Homo sapiens	222-231
22284780-11	2012	Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6.	Quercetin	83-92	interleukin 6	Homo sapiens	236-240
22284780-13	2012	Recent studies further indicate that apigenin, genistein, kaempferol, luteolin, and quercetin potently inhibit VEGF production and suppress ovarian cancer cell metastasis in vitro.	Quercetin	84-93	vascular endothelial growth factor A	Homo sapiens	111-115
22223373-7	2012	Kaempferol and quercetin provide high radical scavenging activity since (i) OH substitutions at C3 and C5 strikingly decrease eta of flavones, (ii) OH substitutions at C3 and C7 decrease chi and eta of flavones, and (iii) phenol or o-catechol substitution at C2 of B ring decrease chi of flavones.	Quercetin	15-24	endothelin receptor type A	Homo sapiens	126-129
22223373-7	2012	Kaempferol and quercetin provide high radical scavenging activity since (i) OH substitutions at C3 and C5 strikingly decrease eta of flavones, (ii) OH substitutions at C3 and C7 decrease chi and eta of flavones, and (iii) phenol or o-catechol substitution at C2 of B ring decrease chi of flavones.	Quercetin	15-24	endothelin receptor type A	Homo sapiens	195-198
23167799-8	2012	Here, we describe a combination of approaches to outline and characterize the role of two flavonoids, quercetin and rutin, on Wnt/beta-catenin signaling, using Xenopus embryos as an experimental model.	Quercetin	102-111	catenin beta 1 L homeolog	Xenopus laevis	130-142
23304202-12	2012	Moreover, quercetin attenuated PI3K, Akt, ERK2, JNK1, and p38 MAPK activations, which were supported by platelet-aggregation inhibition with the respective kinase inhibitors.	Quercetin	10-19	mitogen-activated protein kinase 1	Homo sapiens	58-61
23304202-12	2012	Moreover, quercetin attenuated PI3K, Akt, ERK2, JNK1, and p38 MAPK activations, which were supported by platelet-aggregation inhibition with the respective kinase inhibitors.	Quercetin	10-19	mitogen-activated protein kinase 1	Homo sapiens	62-66
23304202-14	2012	Quercetin-mediated antiplatelet activity involves PI3K/Akt inactivation, cAMP elevation, and VASP stimulation that, in turn, suppresses MAPK phosphorylations.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	55-58
23304202-14	2012	Quercetin-mediated antiplatelet activity involves PI3K/Akt inactivation, cAMP elevation, and VASP stimulation that, in turn, suppresses MAPK phosphorylations.	Quercetin	0-9	vasodilator stimulated phosphoprotein	Homo sapiens	93-97
23304202-14	2012	Quercetin-mediated antiplatelet activity involves PI3K/Akt inactivation, cAMP elevation, and VASP stimulation that, in turn, suppresses MAPK phosphorylations.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	136-140
23304202-12	2012	Moreover, quercetin attenuated PI3K, Akt, ERK2, JNK1, and p38 MAPK activations, which were supported by platelet-aggregation inhibition with the respective kinase inhibitors.	Quercetin	10-19	AKT serine/threonine kinase 1	Homo sapiens	37-40
22690247-7	2012	Quercetin was found to be effective against Cd-induced dysexpression of RST and OAT1 with XOR hyperactivity and impairment of AMPK-PPARalpha/PGC-1beta signal pathway, resulting in renal lipid accumulation reduction of rats.	Quercetin	0-9	solute carrier family 22 member 6	Rattus norvegicus	80-84
22690247-7	2012	Quercetin was found to be effective against Cd-induced dysexpression of RST and OAT1 with XOR hyperactivity and impairment of AMPK-PPARalpha/PGC-1beta signal pathway, resulting in renal lipid accumulation reduction of rats.	Quercetin	0-9	xanthine dehydrogenase	Rattus norvegicus	90-93
23304202-12	2012	Moreover, quercetin attenuated PI3K, Akt, ERK2, JNK1, and p38 MAPK activations, which were supported by platelet-aggregation inhibition with the respective kinase inhibitors.	Quercetin	10-19	mitogen-activated protein kinase 1	Homo sapiens	42-46
22690247-7	2012	Quercetin was found to be effective against Cd-induced dysexpression of RST and OAT1 with XOR hyperactivity and impairment of AMPK-PPARalpha/PGC-1beta signal pathway, resulting in renal lipid accumulation reduction of rats.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	126-130
23304202-12	2012	Moreover, quercetin attenuated PI3K, Akt, ERK2, JNK1, and p38 MAPK activations, which were supported by platelet-aggregation inhibition with the respective kinase inhibitors.	Quercetin	10-19	mitogen-activated protein kinase 8	Homo sapiens	48-52
22690247-7	2012	Quercetin was found to be effective against Cd-induced dysexpression of RST and OAT1 with XOR hyperactivity and impairment of AMPK-PPARalpha/PGC-1beta signal pathway, resulting in renal lipid accumulation reduction of rats.	Quercetin	0-9	peroxisome proliferator activated receptor alpha	Rattus norvegicus	131-140
21993664-0	2012	Proteasome inhibition by quercetin triggers macroautophagy and blocks mTOR activity.	Quercetin	25-34	mechanistic target of rapamycin kinase	Homo sapiens	70-74
22690247-7	2012	Quercetin was found to be effective against Cd-induced dysexpression of RST and OAT1 with XOR hyperactivity and impairment of AMPK-PPARalpha/PGC-1beta signal pathway, resulting in renal lipid accumulation reduction of rats.	Quercetin	0-9	PPARG coactivator 1 beta	Rattus norvegicus	141-150
22548048-4	2012	Results indicated that EEB, rutin, and quercetin + rutin significantly improved 2-NBDG uptake via promoting Akt phosphorylation and preventing PPARgamma degradation caused by high-glucose induction for 48 h in FL83B hepatocytes.	Quercetin	39-48	peroxisome proliferator activated receptor gamma	Mus musculus	143-152
21933852-0	2012	Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin"s lymphoma B cells.	Quercetin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	19-24
21933852-0	2012	Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin"s lymphoma B cells.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	62-67
21933852-5	2012	RESULTS: Results demonstrate that quercetin, a natural flavonoid, restores TRAIL-induced cell death in resistant transformed follicular lymphoma B-cell lines, despite high Bcl-2 expression levels due to the chromosomal translocation t(14;18).	Quercetin	34-43	TNF superfamily member 10	Homo sapiens	75-80
21933852-5	2012	RESULTS: Results demonstrate that quercetin, a natural flavonoid, restores TRAIL-induced cell death in resistant transformed follicular lymphoma B-cell lines, despite high Bcl-2 expression levels due to the chromosomal translocation t(14;18).	Quercetin	34-43	BCL2 apoptosis regulator	Homo sapiens	172-177
21933852-6	2012	Quercetin rescues mitochondrial activation by inducing the proteasomal degradation of Mcl-1 and by inhibiting survivin expression at the mRNA level, irrespective of p53.	Quercetin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	86-91
21933852-8	2012	CONCLUSIONS: We demonstrate that inactivation of survivin and Mcl-1 expression by quercetin is sufficient to restore TRAIL sensitivity in resistant non-Hodgkin"s lymphoma B cells.	Quercetin	82-91	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	62-67
21933852-8	2012	CONCLUSIONS: We demonstrate that inactivation of survivin and Mcl-1 expression by quercetin is sufficient to restore TRAIL sensitivity in resistant non-Hodgkin"s lymphoma B cells.	Quercetin	82-91	TNF superfamily member 10	Homo sapiens	117-122
21993664-4	2012	Prior to the formation of autophagosomes, an immediate and pronounced inhibition of the autophagy-controlling mTOR activity in quercetin-treated cancer cells occurred, accompanied by a marked reduction in the phosphorylation of the mTOR substrates 4E-BP1 and p70S6 kinase.	Quercetin	127-136	mechanistic target of rapamycin kinase	Homo sapiens	110-114
21993664-4	2012	Prior to the formation of autophagosomes, an immediate and pronounced inhibition of the autophagy-controlling mTOR activity in quercetin-treated cancer cells occurred, accompanied by a marked reduction in the phosphorylation of the mTOR substrates 4E-BP1 and p70S6 kinase.	Quercetin	127-136	mechanistic target of rapamycin kinase	Homo sapiens	232-236
21993664-4	2012	Prior to the formation of autophagosomes, an immediate and pronounced inhibition of the autophagy-controlling mTOR activity in quercetin-treated cancer cells occurred, accompanied by a marked reduction in the phosphorylation of the mTOR substrates 4E-BP1 and p70S6 kinase.	Quercetin	127-136	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	248-254
21993664-8	2012	These results suggest potential new applications for quercetin in cancer science and identify quercetin as an easy-to-handle agent to study proteasome activity, mTOR signaling and autophagy in human cancer cells for cell biological purposes.	Quercetin	94-103	mechanistic target of rapamycin kinase	Homo sapiens	161-165
22577570-9	2012	After treatment with quercetin, we observed an improvement in liver complications, decreased fibrosis, as analyzed by picrosirius for the quantification of collagen, and decreased levels of matrix metalloproteinase 2 (MMP-2) compared with the CCl(4) group.	Quercetin	21-30	matrix metallopeptidase 2	Rattus norvegicus	190-216
22690838-10	2012	Hsp70 inhibitor quercetin reduced Hsp70, while aggravating the WBH-induced hepatic changes.	Quercetin	16-25	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	0-5
22690838-10	2012	Hsp70 inhibitor quercetin reduced Hsp70, while aggravating the WBH-induced hepatic changes.	Quercetin	16-25	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	34-39
22577570-9	2012	After treatment with quercetin, we observed an improvement in liver complications, decreased fibrosis, as analyzed by picrosirius for the quantification of collagen, and decreased levels of matrix metalloproteinase 2 (MMP-2) compared with the CCl(4) group.	Quercetin	21-30	matrix metallopeptidase 2	Rattus norvegicus	218-223
22452660-0	2012	Quercetin attenuates TNF-induced inflammation in hepatic cells by inhibiting the NF-kappaB pathway.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	21-24
22452782-7	2012	The synergistic effect of these 2 agents in PC-3 cells could be based on the fact that EGCG primarily inhibited COMT activity, whereas quercetin reduced the amount of COMT protein.	Quercetin	135-144	catechol-O-methyltransferase	Homo sapiens	167-171
22452660-0	2012	Quercetin attenuates TNF-induced inflammation in hepatic cells by inhibiting the NF-kappaB pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	81-90
22452660-3	2012	This study aims to investigate the antiinflammatory effect of quercetin and its role on the NF-kappaB pathway, and cyclooxygenase-2 (COX-2) and mitogen-activated protein kinases modulation in a human hepatoma cell line (HepG2).	Quercetin	62-71	nuclear factor kappa B subunit 1	Homo sapiens	92-101
22452782-2	2012	We therefore investigated whether quercetin, a natural inhibitor of catechol-O-methyl transferase (COMT), will inhibit EGCG methylation leading to enhanced antiproliferative activity of EGCG in prostate cancer cells.	Quercetin	34-43	catechol-O-methyltransferase	Homo sapiens	99-103
22452660-4	2012	Quercetin alone did not modify any of the parameters analyzed but protected cells against activation of the NF-kappaB route induced by tumor necrosis factor-alpha.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	108-117
22452660-4	2012	Quercetin alone did not modify any of the parameters analyzed but protected cells against activation of the NF-kappaB route induced by tumor necrosis factor-alpha.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	135-162
22452660-5	2012	This inhibitory effect of quercetin was mediated, at least in part, by extracellular regulated kinase, c-jun amino-terminal kinase, and reactive oxygen species, and it was accompanied by reduced COX-2 levels.	Quercetin	26-35	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
22452660-5	2012	This inhibitory effect of quercetin was mediated, at least in part, by extracellular regulated kinase, c-jun amino-terminal kinase, and reactive oxygen species, and it was accompanied by reduced COX-2 levels.	Quercetin	26-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	195-200
22452782-2	2012	We therefore investigated whether quercetin, a natural inhibitor of catechol-O-methyl transferase (COMT), will inhibit EGCG methylation leading to enhanced antiproliferative activity of EGCG in prostate cancer cells.	Quercetin	34-43	catechol-O-methyltransferase	Homo sapiens	68-97
23240061-0	2012	Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl.	Quercetin	0-9	transformation related protein 53, pseudogene	Mus musculus	90-93
23240061-5	2012	Z-VAD-fmk (caspase inhibitor), pifithrin-alpha (p53 inhibitor), or overexpressed Bcl-xl decreased the effects of quercetin on DOX-mediated apoptosis.	Quercetin	113-122	BCL2-like 1	Mus musculus	81-87
22919443-3	2012	We first established that quercetin and sesamin defend microglial cells against MPP(+)-induced increases in the mRNA or protein levels of 3 pro-inflammatory cytokines (interleukin-6, IL-1beta and tumor necrosis factor-alpha), as revealed by real time-quantitative polymerase chain reaction and enzyme-linked immunoabsorbent assay, respectively.	Quercetin	26-35	interleukin 6	Rattus norvegicus	168-181
22919443-3	2012	We first established that quercetin and sesamin defend microglial cells against MPP(+)-induced increases in the mRNA or protein levels of 3 pro-inflammatory cytokines (interleukin-6, IL-1beta and tumor necrosis factor-alpha), as revealed by real time-quantitative polymerase chain reaction and enzyme-linked immunoabsorbent assay, respectively.	Quercetin	26-35	interleukin 1 beta	Rattus norvegicus	183-223
22488414-0	2012	Quercetin induces rapid eNOS phosphorylation and vasodilation by an Akt-independent and PKA-dependent mechanism.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	68-71
22488414-9	2012	Quercetin exerted a vasodilatory effect on rings with an intact endothelium but not on endothelium-deprived rings, and also inhibited vascular contractility induced by angiotensin II or phenylephrine in rat aortic rings.	Quercetin	0-9	angiotensinogen	Rattus norvegicus	168-182
22488414-10	2012	We conclude that quercetin quickly phosphorylates eNOS at Ser1179 via an Akt-independent, cAMP/PKA-mediated pathway to enhance the production of NO and to promote vasodilation.	Quercetin	17-26	AKT serine/threonine kinase 1	Rattus norvegicus	73-76
23240061-0	2012	Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl.	Quercetin	0-9	BCL2-like 1	Mus musculus	94-100
23240061-3	2012	METHODOLOGY AND RESULTS: The MTT and Annexin V/PI staining assay demonstrated that quercetin selectively sensitized DOX-induced cytotoxicity against liver cancer cells while protecting normal liver cells.	Quercetin	83-92	annexin A5	Mus musculus	37-46
23240061-4	2012	The increase in DOX-mediated apoptosis in hepatoma cells by quercetin was p53-dependent and occurred by downregulating Bcl-xl expression.	Quercetin	60-69	transformation related protein 53, pseudogene	Mus musculus	74-77
23240061-4	2012	The increase in DOX-mediated apoptosis in hepatoma cells by quercetin was p53-dependent and occurred by downregulating Bcl-xl expression.	Quercetin	60-69	BCL2-like 1	Mus musculus	119-125
23240061-5	2012	Z-VAD-fmk (caspase inhibitor), pifithrin-alpha (p53 inhibitor), or overexpressed Bcl-xl decreased the effects of quercetin on DOX-mediated apoptosis.	Quercetin	113-122	transformation related protein 53, pseudogene	Mus musculus	48-51
23152886-0	2012	Quercetin suppresses drug-resistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cells.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	52-55
23152886-0	2012	Quercetin suppresses drug-resistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cells.	Quercetin	0-9	heat shock protein family B (small) member 1	Homo sapiens	61-66
23152886-10	2012	Furthermore, an inhibitor of Hsp27, quercetin (Qu), suppressed p-Hsp27 expression, with alterations of the EMT signature, leading to the promotion of apoptosis in DRSPs.	Quercetin	36-45	heat shock protein family B (small) member 1	Homo sapiens	29-34
23152886-10	2012	Furthermore, an inhibitor of Hsp27, quercetin (Qu), suppressed p-Hsp27 expression, with alterations of the EMT signature, leading to the promotion of apoptosis in DRSPs.	Quercetin	36-45	heat shock protein family B (small) member 1	Homo sapiens	65-70
22443056-9	2012	The pretreatment of HSP70 transcription inhibitor quercetin could significantly inhibit the expression of HSP70 mRNA., and increase the expression of phosphorylated JNK, while increase the apoptosis rate in comparison with UVA model group observed by using Hoechst 33258 fluorescent staining.	Quercetin	50-59	heat shock protein family A (Hsp70) member 4	Homo sapiens	20-25
23094058-0	2012	Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways.	Quercetin	0-9	kinase insert domain receptor	Homo sapiens	82-90
23094058-0	2012	Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	101-104
23094058-0	2012	Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	105-109
23094058-0	2012	Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways.	Quercetin	0-9	ribosomal protein S6 kinase B1	Homo sapiens	110-116
23094058-6	2012	Western blot analysis showed that quercetin suppressed VEGF induced phosphorylation of VEGF receptor 2 and their downstream protein kinases AKT, mTOR, and ribosomal protein S6 kinase in HUVECs.	Quercetin	34-43	vascular endothelial growth factor A	Homo sapiens	55-59
23094058-6	2012	Western blot analysis showed that quercetin suppressed VEGF induced phosphorylation of VEGF receptor 2 and their downstream protein kinases AKT, mTOR, and ribosomal protein S6 kinase in HUVECs.	Quercetin	34-43	vascular endothelial growth factor A	Homo sapiens	87-91
23094058-6	2012	Western blot analysis showed that quercetin suppressed VEGF induced phosphorylation of VEGF receptor 2 and their downstream protein kinases AKT, mTOR, and ribosomal protein S6 kinase in HUVECs.	Quercetin	34-43	AKT serine/threonine kinase 1	Homo sapiens	140-143
23094058-6	2012	Western blot analysis showed that quercetin suppressed VEGF induced phosphorylation of VEGF receptor 2 and their downstream protein kinases AKT, mTOR, and ribosomal protein S6 kinase in HUVECs.	Quercetin	34-43	mechanistic target of rapamycin kinase	Homo sapiens	145-149
23094058-8	2012	Furthermore, quercetin reduced the cell viability and induced apoptosis in prostate cancer cells, which were correlated with the downregulation of AKT, mTOR and P70S6K expressions.	Quercetin	13-22	AKT serine/threonine kinase 1	Homo sapiens	147-150
23094058-8	2012	Furthermore, quercetin reduced the cell viability and induced apoptosis in prostate cancer cells, which were correlated with the downregulation of AKT, mTOR and P70S6K expressions.	Quercetin	13-22	mechanistic target of rapamycin kinase	Homo sapiens	152-156
23094058-8	2012	Furthermore, quercetin reduced the cell viability and induced apoptosis in prostate cancer cells, which were correlated with the downregulation of AKT, mTOR and P70S6K expressions.	Quercetin	13-22	ribosomal protein S6 kinase B1	Homo sapiens	161-167
23094058-9	2012	Collectively the findings in the present study suggest that quercetin inhibits tumor growth and angiogenesis by targeting VEGF-R2 regulated AKT/mTOR/P70S6K signaling pathway, and could be used as a potential drug candidate for cancer therapy.	Quercetin	60-69	vascular endothelial growth factor A	Homo sapiens	122-126
23094058-9	2012	Collectively the findings in the present study suggest that quercetin inhibits tumor growth and angiogenesis by targeting VEGF-R2 regulated AKT/mTOR/P70S6K signaling pathway, and could be used as a potential drug candidate for cancer therapy.	Quercetin	60-69	AKT serine/threonine kinase 1	Homo sapiens	140-143
23094058-9	2012	Collectively the findings in the present study suggest that quercetin inhibits tumor growth and angiogenesis by targeting VEGF-R2 regulated AKT/mTOR/P70S6K signaling pathway, and could be used as a potential drug candidate for cancer therapy.	Quercetin	60-69	mechanistic target of rapamycin kinase	Homo sapiens	144-148
23094058-9	2012	Collectively the findings in the present study suggest that quercetin inhibits tumor growth and angiogenesis by targeting VEGF-R2 regulated AKT/mTOR/P70S6K signaling pathway, and could be used as a potential drug candidate for cancer therapy.	Quercetin	60-69	ribosomal protein S6 kinase B1	Homo sapiens	149-155
22701621-0	2012	Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation.	Quercetin	0-9	NLR family, pyrin domain containing 3	Rattus norvegicus	96-101
22470478-9	2012	However, Que is more effective than cromolyn in inhibiting IL-8 and TNF release from LAD2 mast cells stimulated by SP.	Quercetin	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
22470478-9	2012	However, Que is more effective than cromolyn in inhibiting IL-8 and TNF release from LAD2 mast cells stimulated by SP.	Quercetin	9-12	tumor necrosis factor	Homo sapiens	68-71
22470478-11	2012	Que inhibits cytosolic calcium level increase and NF-kappa B activation.	Quercetin	0-3	nuclear factor kappa B subunit 1	Homo sapiens	50-60
22011322-0	2012	Quercetin ameliorates diabetic nephropathy by reducing the expressions of transforming growth factor-beta1 and connective tissue growth factor in streptozotocin-induced diabetic rats.	Quercetin	0-9	transforming growth factor, beta 1	Rattus norvegicus	74-106
22011322-0	2012	Quercetin ameliorates diabetic nephropathy by reducing the expressions of transforming growth factor-beta1 and connective tissue growth factor in streptozotocin-induced diabetic rats.	Quercetin	0-9	cellular communication network factor 2	Rattus norvegicus	111-142
22011322-4	2012	In this study, we aim to examine whether quercetin ameliorates renal function through an effect on the expressions of TGF-beta1 and CTGF in streptozotocin (STZ)-induced diabetic rats.	Quercetin	41-50	transforming growth factor, beta 1	Rattus norvegicus	118-127
22011322-4	2012	In this study, we aim to examine whether quercetin ameliorates renal function through an effect on the expressions of TGF-beta1 and CTGF in streptozotocin (STZ)-induced diabetic rats.	Quercetin	41-50	cellular communication network factor 2	Rattus norvegicus	132-136
22011322-12	2012	The overexpressions of TGF-beta1 and CTGF in the renal tissues of diabetic rats were attenuated by administration of quercetin.	Quercetin	117-126	transforming growth factor, beta 1	Rattus norvegicus	23-32
22011322-12	2012	The overexpressions of TGF-beta1 and CTGF in the renal tissues of diabetic rats were attenuated by administration of quercetin.	Quercetin	117-126	cellular communication network factor 2	Rattus norvegicus	37-41
22011322-13	2012	Our results suggest that quercetin improved renal function in rats with DN by inhibiting the overexpressions of TGF-beta1 and CTGF in the kidney.	Quercetin	25-34	transforming growth factor, beta 1	Rattus norvegicus	112-121
22011322-13	2012	Our results suggest that quercetin improved renal function in rats with DN by inhibiting the overexpressions of TGF-beta1 and CTGF in the kidney.	Quercetin	25-34	cellular communication network factor 2	Rattus norvegicus	126-130
22230496-0	2012	[Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway].	Quercetin	1-10	leptin	Homo sapiens	19-25
22230496-1	2012	AIM: Quercetin affects the expressions of leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway.	Quercetin	5-14	leptin	Homo sapiens	42-48
22724024-8	2012	Inhibition of both routes through selected molecules (SB203580, quercetin, artemisinin, parthenolide) prevented HZ-dependent lysozyme release.	Quercetin	64-73	lysozyme	Homo sapiens	125-133
22701621-8	2012	Furthermore, quercetin and allopurinol were found to suppress renal NLRP3 inflammasome activation, at least partly, via their anti-hyperuricemic and anti-dyslipidemic effects, resulting in the amelioration of STZ-induced the superimposed nephrotoxicity in rats.	Quercetin	13-22	NLR family, pyrin domain containing 3	Rattus norvegicus	68-73
22443056-9	2012	The pretreatment of HSP70 transcription inhibitor quercetin could significantly inhibit the expression of HSP70 mRNA., and increase the expression of phosphorylated JNK, while increase the apoptosis rate in comparison with UVA model group observed by using Hoechst 33258 fluorescent staining.	Quercetin	50-59	heat shock protein family A (Hsp70) member 4	Homo sapiens	106-111
22443056-9	2012	The pretreatment of HSP70 transcription inhibitor quercetin could significantly inhibit the expression of HSP70 mRNA., and increase the expression of phosphorylated JNK, while increase the apoptosis rate in comparison with UVA model group observed by using Hoechst 33258 fluorescent staining.	Quercetin	50-59	mitogen-activated protein kinase 8	Homo sapiens	165-168
22001349-8	2011	Up-regulation of HSP72 by geranylgeranylacetone increased autophagy, inhibited apoptosis, and attenuated peritoneal injury, and these effects were blunted by down-regulation of HSP72 with quercetin.	Quercetin	188-197	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	17-22
22185406-2	2011	We have recently reported that proteasome inhibitors (dexamethasone, mevinolin, quercetin, delta-tocotrienol, and riboflavin) can inhibit lipopolysaccharide (LPS)-induced NO production in vitro by RAW 264.7 cells and by thioglycolate-elicited peritoneal macrophages derived from four strains of mice (C57BL/6, BALB/c, LMP7/MECL-1(-/-) and PPAR-alpha(-/-) knockout mice).	Quercetin	80-89	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	Mus musculus	318-322
22185406-2	2011	We have recently reported that proteasome inhibitors (dexamethasone, mevinolin, quercetin, delta-tocotrienol, and riboflavin) can inhibit lipopolysaccharide (LPS)-induced NO production in vitro by RAW 264.7 cells and by thioglycolate-elicited peritoneal macrophages derived from four strains of mice (C57BL/6, BALB/c, LMP7/MECL-1(-/-) and PPAR-alpha(-/-) knockout mice).	Quercetin	80-89	proteasome (prosome, macropain) subunit, beta type 10	Mus musculus	323-329
22185406-2	2011	We have recently reported that proteasome inhibitors (dexamethasone, mevinolin, quercetin, delta-tocotrienol, and riboflavin) can inhibit lipopolysaccharide (LPS)-induced NO production in vitro by RAW 264.7 cells and by thioglycolate-elicited peritoneal macrophages derived from four strains of mice (C57BL/6, BALB/c, LMP7/MECL-1(-/-) and PPAR-alpha(-/-) knockout mice).	Quercetin	80-89	peroxisome proliferator activated receptor alpha	Mus musculus	339-349
22064046-6	2011	However, adult mice prenatally exposed to quercetin had significant increase iron storage in the liver, by upregulating iron-associated cytokine expression (hepcidin, IL-1beta, IL-6 and IL-10).	Quercetin	42-51	hepcidin antimicrobial peptide	Mus musculus	157-165
22064046-6	2011	However, adult mice prenatally exposed to quercetin had significant increase iron storage in the liver, by upregulating iron-associated cytokine expression (hepcidin, IL-1beta, IL-6 and IL-10).	Quercetin	42-51	interleukin 1 beta	Mus musculus	167-175
22064046-6	2011	However, adult mice prenatally exposed to quercetin had significant increase iron storage in the liver, by upregulating iron-associated cytokine expression (hepcidin, IL-1beta, IL-6 and IL-10).	Quercetin	42-51	interleukin 6	Mus musculus	177-181
22064046-6	2011	However, adult mice prenatally exposed to quercetin had significant increase iron storage in the liver, by upregulating iron-associated cytokine expression (hepcidin, IL-1beta, IL-6 and IL-10).	Quercetin	42-51	interleukin 10	Mus musculus	186-191
22115781-4	2011	In this study, we demonstrate that ER stress induces presenilin-1 expression through activating transcription factor 4 (ATF4), resulting in increased amyloid-beta (Abeta) secretion by gamma-secretase activity, which is suppressed by quercetin by modifying UPR signaling.	Quercetin	233-242	presenilin 1	Homo sapiens	53-65
22115781-4	2011	In this study, we demonstrate that ER stress induces presenilin-1 expression through activating transcription factor 4 (ATF4), resulting in increased amyloid-beta (Abeta) secretion by gamma-secretase activity, which is suppressed by quercetin by modifying UPR signaling.	Quercetin	233-242	activating transcription factor 4	Homo sapiens	120-124
22079288-3	2011	The results demonstrated that quercetin dose-dependently inhibited amyloid formation of insulin.	Quercetin	30-39	insulin	Bos taurus	88-95
22079288-4	2011	Moreover, quercetin destabilized the preformed insulin fibrils and transformed the fibrils into amorphous aggregates.	Quercetin	10-19	insulin	Bos taurus	47-54
22079288-7	2011	SDS-PAGE showed that insulin fibrils induced the aggregation of cytoskeletal proteins of erythrocyte membranes and that quercetin attenuated this fibril-induced cytoskeletal aggregation.	Quercetin	120-129	insulin	Bos taurus	21-28
22185406-8	2011	There was a 2-fold increase in the production of NO, when LPS-stimulated macrophages of quercetin, delta-tocotrienol, or dexamethasone were also treated with IFN-beta or IFN-gamma compared to respective control groups.	Quercetin	88-97	interferon beta 1, fibroblast	Mus musculus	158-166
22185406-8	2011	There was a 2-fold increase in the production of NO, when LPS-stimulated macrophages of quercetin, delta-tocotrienol, or dexamethasone were also treated with IFN-beta or IFN-gamma compared to respective control groups.	Quercetin	88-97	interferon gamma	Mus musculus	170-179
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	interleukin 1 beta	Mus musculus	189-197
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	interleukin 1 alpha	Mus musculus	199-208
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	interleukin 6	Mus musculus	210-214
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	tumor necrosis factor	Mus musculus	216-225
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	nitric oxide synthase 2, inducible	Mus musculus	234-238
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	vascular cell adhesion molecule 1	Mus musculus	240-245
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	intercellular adhesion molecule 1	Mus musculus	247-252
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	cytochrome c oxidase II, mitochondrial	Mus musculus	254-258
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	interleukin 1 receptor antagonist	Mus musculus	260-266
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	TNF receptor-associated factor 1	Mus musculus	268-273
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	CD40 antigen	Mus musculus	278-282
22133267-2	2011	Quercetin and isoquercetin are both powerful alpha-glucosidase inhibitors.	Quercetin	0-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	45-62
22133267-3	2011	Although the IC50 of isoquercetin as alpha-glucosidase inhibitor was much higher than that of quercetin, the bioavailability of isoquercetin was higher than that of quercetin.	Quercetin	24-33	sucrase isomaltase (alpha-glucosidase)	Mus musculus	37-54
22001349-8	2011	Up-regulation of HSP72 by geranylgeranylacetone increased autophagy, inhibited apoptosis, and attenuated peritoneal injury, and these effects were blunted by down-regulation of HSP72 with quercetin.	Quercetin	188-197	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	177-182
21479885-0	2011	Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation.	Quercetin	0-9	tumor protein p53	Homo sapiens	91-94
21858734-9	2011	By contrast, quercetin significantly suppressed the SCr and BUN levels in the cisplatin-treated rats and protected them against renal injury with the decreased expression of Kim-1.	Quercetin	13-22	hepatitis A virus cellular receptor 1	Rattus norvegicus	174-179
21994207-0	2011	Enhancement of carboplatin- and quercetin-induced cell death by roscovitine is Akt dependent and p53 independent in hepatoma cells.	Quercetin	32-41	AKT serine/threonine kinase 1	Homo sapiens	79-82
21196432-0	2011	Exploiting tyrosinase expression and activity in melanocytic tumors: quercetin and the central role of p53.	Quercetin	69-78	tyrosinase	Homo sapiens	11-21
21196432-5	2011	Both strategies could use tyrosinase-mediated activation of quercetin, a dietary polyphenol that induces the expression of p53 and modulates reactive oxygen species.	Quercetin	60-69	tyrosinase	Homo sapiens	26-36
21196432-5	2011	Both strategies could use tyrosinase-mediated activation of quercetin, a dietary polyphenol that induces the expression of p53 and modulates reactive oxygen species.	Quercetin	60-69	tumor protein p53	Homo sapiens	123-126
21196432-6	2011	In addition to antitumor signaling properties, activation of quercetin could complement conventional cancer therapy by the induction of phase II detoxification enzymes resulting in p53 stabilization and transduction of its downstream targets.	Quercetin	61-70	tumor protein p53	Homo sapiens	181-184
22005028-10	2011	Ectopic expression of SFRP1 and quercetin treatment was able to mitigate Wnt3a-mediated phenotype of KFs.	Quercetin	32-41	Wnt family member 3A	Homo sapiens	73-78
21994207-0	2011	Enhancement of carboplatin- and quercetin-induced cell death by roscovitine is Akt dependent and p53 independent in hepatoma cells.	Quercetin	32-41	tumor protein p53	Homo sapiens	97-100
22075574-5	2011	In the LPS-stimulated inducible nitric oxide synthase (iNOS) activation analysis, two known compounds, quercetin (1) and ethyl caffeate (6), were found to markedly suppress nitric oxide (NO) production (IC50 value, 27.6 and 42.9 muM, respectively) in RAW264.7 cells.	Quercetin	103-112	nitric oxide synthase 2, inducible	Mus musculus	22-53
22070678-4	2011	Quercetin can also upregulate proteins that abrogate free radical damage, such as p53.	Quercetin	0-9	tumor protein p53	Homo sapiens	82-85
21914440-7	2011	Quercetin at 5mg/kg showed little effect on diabetic osteopenia, while quercetin at 30 mg/kg and 50mg/kg could increase the decreased serum osteocalcin, serum alkaline phosphatase activity, and urinary deoxypyridinoline in diabetic rats.	Quercetin	71-80	bone gamma-carboxyglutamate protein	Rattus norvegicus	140-151
22075574-5	2011	In the LPS-stimulated inducible nitric oxide synthase (iNOS) activation analysis, two known compounds, quercetin (1) and ethyl caffeate (6), were found to markedly suppress nitric oxide (NO) production (IC50 value, 27.6 and 42.9 muM, respectively) in RAW264.7 cells.	Quercetin	103-112	nitric oxide synthase 2, inducible	Mus musculus	55-59
21964380-5	2011	In addition, quercetin repressed the expression of the pro-apoptotic Bax gene and enhanced that of the anti-apoptotic Bcl-2 gene in SH-SY5Y cells.	Quercetin	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	69-72
21896783-9	2011	In addition to nitric oxide, stimulation of IRE1 endoribonuclease activity with the flavonol quercetin leads to IRE1-dependent AMPK activation.	Quercetin	93-102	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	44-48
21896783-9	2011	In addition to nitric oxide, stimulation of IRE1 endoribonuclease activity with the flavonol quercetin leads to IRE1-dependent AMPK activation.	Quercetin	93-102	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	112-116
21896783-9	2011	In addition to nitric oxide, stimulation of IRE1 endoribonuclease activity with the flavonol quercetin leads to IRE1-dependent AMPK activation.	Quercetin	93-102	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	127-131
21915944-9	2011	In addition, upregulation of erythropoiesis by LPA was also blocked by quercetin, an inhibitor of the beta-catenin/T-cell factor pathway.	Quercetin	71-80	catenin beta 1	Homo sapiens	102-114
21964380-5	2011	In addition, quercetin repressed the expression of the pro-apoptotic Bax gene and enhanced that of the anti-apoptotic Bcl-2 gene in SH-SY5Y cells.	Quercetin	13-22	BCL2 apoptosis regulator	Homo sapiens	118-123
21899256-3	2011	Here we analyzed the interaction of GLUT1 with quercetin (a flavone), genistein (an isoflavone), and tyrphostin A47 and B46 to evaluate if they share one common or have several binding sites on the protein.	Quercetin	47-56	solute carrier family 2 member 1	Homo sapiens	36-41
22023707-6	2011	To study the involvement of Hsp27 in BCSC biology, siRNA mediated gene silencing and quercetin treatment were used to inhibit Hsp27 expression and the characters of BCSCs, which include ALDH+ population, mammosphere formation and cell migration, were analyzed simultaneously.	Quercetin	85-94	heat shock protein 1	Mus musculus	126-131
22023707-13	2011	The inhibitory effects could also be observed in cells treated with quercetin, a plant flavonoid inhibitor of Hsp27, and it could be reversed by overexpression of Hsp27.	Quercetin	68-77	heat shock protein 1	Mus musculus	110-115
22023707-13	2011	The inhibitory effects could also be observed in cells treated with quercetin, a plant flavonoid inhibitor of Hsp27, and it could be reversed by overexpression of Hsp27.	Quercetin	68-77	heat shock protein 1	Mus musculus	163-168
21924266-1	2011	Rutin and quercetin, both minor components of green tea and their Cu(II) complexes interact with Ribonuclease A (RNase A) in a novel way.	Quercetin	10-19	ribonuclease A family member 1, pancreatic	Homo sapiens	97-111
21924266-1	2011	Rutin and quercetin, both minor components of green tea and their Cu(II) complexes interact with Ribonuclease A (RNase A) in a novel way.	Quercetin	10-19	ribonuclease A family member 1, pancreatic	Homo sapiens	113-120
21924266-3	2011	Rutin shows an enhancement in the ribonucleolytic activity whereas the copper complexes and quercetin behave as non-competitive type inhibitors with K(i) values in the muM range.	Quercetin	92-101	latexin	Homo sapiens	168-171
21924266-0	2011	Complex formation of rutin and quercetin with copper alters the mode of inhibition of ribonuclease A.	Quercetin	31-40	ribonuclease A family member 1, pancreatic	Homo sapiens	86-100
21899256-4	2011	Kinetic assays showed that genistein, quercetin, and tyrphostin B46 behave as competitive inhibitors of equilibrium exchange and zero-trans uptake transport and noncompetitive inhibitors of net sugar exit out of human red cells, suggesting that they interact with the external surface of the GLUT1 molecule.	Quercetin	38-47	solute carrier family 2 member 1	Homo sapiens	292-297
22128260-3	2011	In this study, we demonstrated that large conductance Ca(2+)-activated K(+) (BK(Ca)) or MaxiK channels were functionally expressed in 253J cells, and quercetin increased BK(Ca) current in a concentration dependent and reversible manner using a whole cell patch configuration.	Quercetin	150-159	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	88-93
21810460-9	2011	We evaluated that ETL and the reference compound of quercetin decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells.	Quercetin	52-61	nitric oxide synthase 2, inducible	Mus musculus	121-125
21810460-9	2011	We evaluated that ETL and the reference compound of quercetin decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells.	Quercetin	52-61	prostaglandin-endoperoxide synthase 2	Mus musculus	130-135
21965740-3	2011	This study aimed to examine the effect of genistein and quercetin on proliferation and apoptosis in HER2-expressing breast cancer cells.	Quercetin	56-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-104
21965740-7	2011	RESULTS: Genistein and quercetin inhibited the proliferation of MCF-7 vec and MCF-7 HER2 cells.	Quercetin	23-32	erb-b2 receptor tyrosine kinase 2	Homo sapiens	84-88
21965740-9	2011	Genistein and quercetin induced extrinsic apoptosis pathway, up-regulating p53.	Quercetin	14-23	tumor protein p53	Homo sapiens	75-78
21965740-10	2011	Genistein and quercetin reduced the phosphorylation level of IkappaBalpha, and abrogated the nuclear translocation of p65 and its phosphorylation within the nucleus.	Quercetin	14-23	NFKB inhibitor alpha	Homo sapiens	61-73
21965740-10	2011	Genistein and quercetin reduced the phosphorylation level of IkappaBalpha, and abrogated the nuclear translocation of p65 and its phosphorylation within the nucleus.	Quercetin	14-23	RELA proto-oncogene, NF-kB subunit	Homo sapiens	118-121
21965740-11	2011	CONCLUSION: Genistein and quercetin exert their antiproliferative activity by inhibiting NFkappaB signaling.	Quercetin	26-35	nuclear factor kappa B subunit 1	Homo sapiens	89-97
21752154-6	2011	Overexpression of MMP-9 resulted in induction of the EMT in A431-P cells and this could be reversed by treating with luteolin or quercetin.	Quercetin	129-138	matrix metallopeptidase 9	Homo sapiens	18-23
21752154-8	2011	E-cadherin was decreased by EGF, but increased by luteolin and quercetin.	Quercetin	63-72	cadherin 1	Homo sapiens	0-10
21893570-0	2011	Phytotherapy in a rat model of hyperoxaluria: the antioxidant effects of quercetin involve serum paraoxonase 1 activation.	Quercetin	73-82	paraoxonase 1	Rattus norvegicus	97-110
21769418-0	2011	Quercetin, a potent suppressor of NF-kappaB and Smad activation in osteoblasts.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	34-43
21769418-2	2011	Quercetin is a ubiquitous plant-derived flavonoid with well documented anti-inflammatory properties, in part, a consequence of its capacity to downmodulate the NF-kappaB signal transduction pathway.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	160-169
21769418-6	2011	As expected, quercetin potently suppressed osteoclastogenesis and NF-kappaB activation induced by RANKL in osteoclast precursors.	Quercetin	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
21769418-6	2011	As expected, quercetin potently suppressed osteoclastogenesis and NF-kappaB activation induced by RANKL in osteoclast precursors.	Quercetin	13-22	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	98-103
21769418-7	2011	However, the same doses of quercetin had no effect on osteoblast mineralization, and failed to significantly alleviate the inhibitory effect of NF-kappaB-induced by TNFalpha, even though quercetin potently suppressed NF-kappaB activation in these cells.	Quercetin	187-196	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	217-226
21769418-8	2011	This apparent contradiction was explained by the fact that addition to its anti-NF-kappaB activity, quercetin also potently antagonized both TGFbeta and BMP-2-induced Smad activation in osteoblast precursors.	Quercetin	100-109	bone morphogenetic protein 2	Mus musculus	153-158
21992595-15	2011	CONCLUSIONS: Results of the current study demonstrate that delta-tocotrienol, riboflavin, and quercetin inhibit NO production by LPS-stimulated macrophages of all four strains of mice, and TNF-alpha, secretion only by LPS-stimulated macrophages of C57BL/6 and BALB/c mice.	Quercetin	94-103	tumor necrosis factor	Mus musculus	189-198
22335904-1	2011	OBJECTIVE: To detect the changes of heat shock protein(HSP) expression in human hepatocellular carcinoma HepG2 cells after treated by quercetin through a proteomics strategy termed SILAC (stable isotope labeling by amino acids in cell culture)-MS (mass spectrometry).	Quercetin	134-143	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	36-59
21624509-0	2011	Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity.	Quercetin	20-29	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
21624509-8	2011	Quercetin-induced MT expression may function by activating the phosphorylation of JNK, p38 and PI3K/Akt as well as by enhancing Nrf2 DNA-binding activity.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	87-90
21624509-8	2011	Quercetin-induced MT expression may function by activating the phosphorylation of JNK, p38 and PI3K/Akt as well as by enhancing Nrf2 DNA-binding activity.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	100-103
21624509-8	2011	Quercetin-induced MT expression may function by activating the phosphorylation of JNK, p38 and PI3K/Akt as well as by enhancing Nrf2 DNA-binding activity.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
21885874-7	2011	Quercetin treatment caused significant decreases in lipid peroxide levels in the TAA-treated rats, with some changes in antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx).	Quercetin	0-9	catalase	Rattus norvegicus	168-176
21885874-7	2011	Quercetin treatment caused significant decreases in lipid peroxide levels in the TAA-treated rats, with some changes in antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx).	Quercetin	0-9	catalase	Rattus norvegicus	178-181
21885874-8	2011	Quercetin also inhibited the change of the p-ERK1/2 by TAA and significantly prevented the increase in Bax/Bcl-2 ratio, thus preventing apoptosis.	Quercetin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	45-51
21885874-8	2011	Quercetin also inhibited the change of the p-ERK1/2 by TAA and significantly prevented the increase in Bax/Bcl-2 ratio, thus preventing apoptosis.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Rattus norvegicus	103-106
21885874-8	2011	Quercetin also inhibited the change of the p-ERK1/2 by TAA and significantly prevented the increase in Bax/Bcl-2 ratio, thus preventing apoptosis.	Quercetin	0-9	BCL2, apoptosis regulator	Rattus norvegicus	107-112
22335904-12	2011	The expression of HSP90 exposed to quercetin for 48 h was decreased to 49.3% of the normal HepG2 cells, and the expression of HSP70 was decreased to 43.6% of the normal Hep G2 cells.	Quercetin	35-44	heat shock protein 90 alpha family class A member 1	Homo sapiens	18-23
22186243-0	2011	Quercetin increases cystic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: therapeutic implications for chronic rhinosinusitis.	Quercetin	0-9	CF transmembrane conductance regulator	Homo sapiens	20-71
22141284-8	2011	Furthermore, quercetin treatment in rats undergoing status epilepticus led to an interventional effect on expression of X-linked inhibitor of apoptosis protein and the caspase-3 protein, with a corresponding positive change on the number of hippocampal apoptotic and surviving neurons.	Quercetin	13-22	X-linked inhibitor of apoptosis	Rattus norvegicus	120-159
22141284-8	2011	Furthermore, quercetin treatment in rats undergoing status epilepticus led to an interventional effect on expression of X-linked inhibitor of apoptosis protein and the caspase-3 protein, with a corresponding positive change on the number of hippocampal apoptotic and surviving neurons.	Quercetin	13-22	caspase 3	Rattus norvegicus	168-177
22141284-9	2011	Together, the study suggests neuroprotective effects of quercetin on hippocampal injury post status epilepticus and the effects may be associated with regulation of the X-linked inhibitor of apoptosis protein and the caspase-3 protein, which can be a decisive factor for apoptosis and survival of neurons in hippocampus.	Quercetin	56-65	X-linked inhibitor of apoptosis	Rattus norvegicus	169-208
22141284-9	2011	Together, the study suggests neuroprotective effects of quercetin on hippocampal injury post status epilepticus and the effects may be associated with regulation of the X-linked inhibitor of apoptosis protein and the caspase-3 protein, which can be a decisive factor for apoptosis and survival of neurons in hippocampus.	Quercetin	56-65	caspase 3	Rattus norvegicus	217-226
21601209-3	2011	METHODS: After evaluating its anti-oxidative and anti-inflammatory effects in cultured human cells, quercetin (0.1%, w/w in diet) was given to human CRP transgenic mice, a humanized inflammation model, and ApoE*3Leiden transgenic mice, a humanized atherosclerosis model.	Quercetin	100-109	C-reactive protein	Homo sapiens	149-152
21601209-5	2011	RESULTS: In cultured human endothelial cells, quercetin protected against H(2)O(2)-induced lipid peroxidation and reduced the cytokine-induced cell-surface expression of VCAM-1 and E-selectin.	Quercetin	46-55	vascular cell adhesion molecule 1	Homo sapiens	170-176
21601209-5	2011	RESULTS: In cultured human endothelial cells, quercetin protected against H(2)O(2)-induced lipid peroxidation and reduced the cytokine-induced cell-surface expression of VCAM-1 and E-selectin.	Quercetin	46-55	selectin E	Homo sapiens	181-191
21601209-6	2011	Quercetin also reduced the transcriptional activity of NFkappaB in human hepatocytes.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	55-63
21601209-7	2011	In human CRP transgenic mice (quercetin plasma concentration: 12.9 +- 1.3 muM), quercetin quenched IL1beta-induced CRP expression, as did sodium salicylate.	Quercetin	80-89	C-reactive protein	Homo sapiens	9-12
21601209-7	2011	In human CRP transgenic mice (quercetin plasma concentration: 12.9 +- 1.3 muM), quercetin quenched IL1beta-induced CRP expression, as did sodium salicylate.	Quercetin	80-89	interleukin 1 beta	Mus musculus	99-106
21601209-7	2011	In human CRP transgenic mice (quercetin plasma concentration: 12.9 +- 1.3 muM), quercetin quenched IL1beta-induced CRP expression, as did sodium salicylate.	Quercetin	80-89	C-reactive protein, pentraxin-related	Mus musculus	115-118
21601209-9	2011	Quercetin did not affect atherogenic plasma lipids or lipoproteins but it significantly lowered the circulating inflammatory risk factors SAA and fibrinogen.	Quercetin	0-9	serum amyloid A1 cluster	Homo sapiens	138-141
21601209-9	2011	Quercetin did not affect atherogenic plasma lipids or lipoproteins but it significantly lowered the circulating inflammatory risk factors SAA and fibrinogen.	Quercetin	0-9	fibrinogen beta chain	Homo sapiens	146-156
21601209-11	2011	Quercetin also reduced the gene expression of specific factors implicated in local vascular inflammation including IL-1R, Ccl8, IKK, and STAT3.	Quercetin	0-9	C-C motif chemokine ligand 8	Homo sapiens	122-126
21601209-11	2011	Quercetin also reduced the gene expression of specific factors implicated in local vascular inflammation including IL-1R, Ccl8, IKK, and STAT3.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	137-142
21601209-12	2011	CONCLUSION: Quercetin reduces the expression of human CRP and cardiovascular risk factors (SAA, fibrinogen) in mice in vivo.	Quercetin	12-21	C-reactive protein	Homo sapiens	54-57
21601209-12	2011	CONCLUSION: Quercetin reduces the expression of human CRP and cardiovascular risk factors (SAA, fibrinogen) in mice in vivo.	Quercetin	12-21	serum amyloid A1 cluster	Homo sapiens	91-94
21601209-12	2011	CONCLUSION: Quercetin reduces the expression of human CRP and cardiovascular risk factors (SAA, fibrinogen) in mice in vivo.	Quercetin	12-21	fibrinogen beta chain	Homo sapiens	96-106
21610320-0	2011	Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	79-82
21610320-5	2011	Furthermore, either administration of autophagic inhibitor chloroquine or selective ablation of atg5 or beclin 1 using small interfering RNA (siRNA) could augment quercetin-induced apoptotic cell death, suggesting that autophagy plays a protective role against quercetin-induced apoptosis.	Quercetin	163-172	autophagy related 5	Homo sapiens	96-100
21610320-5	2011	Furthermore, either administration of autophagic inhibitor chloroquine or selective ablation of atg5 or beclin 1 using small interfering RNA (siRNA) could augment quercetin-induced apoptotic cell death, suggesting that autophagy plays a protective role against quercetin-induced apoptosis.	Quercetin	163-172	beclin 1	Homo sapiens	104-112
21610320-5	2011	Furthermore, either administration of autophagic inhibitor chloroquine or selective ablation of atg5 or beclin 1 using small interfering RNA (siRNA) could augment quercetin-induced apoptotic cell death, suggesting that autophagy plays a protective role against quercetin-induced apoptosis.	Quercetin	261-270	autophagy related 5	Homo sapiens	96-100
21610320-5	2011	Furthermore, either administration of autophagic inhibitor chloroquine or selective ablation of atg5 or beclin 1 using small interfering RNA (siRNA) could augment quercetin-induced apoptotic cell death, suggesting that autophagy plays a protective role against quercetin-induced apoptosis.	Quercetin	261-270	beclin 1	Homo sapiens	104-112
21610320-6	2011	Moreover, functional studies revealed that quercetin activated autophagy by modulation of Akt-mTOR signaling and hypoxia-induced factor 1alpha (HIF-1alpha) signaling.	Quercetin	43-52	AKT serine/threonine kinase 1	Homo sapiens	90-93
21610320-6	2011	Moreover, functional studies revealed that quercetin activated autophagy by modulation of Akt-mTOR signaling and hypoxia-induced factor 1alpha (HIF-1alpha) signaling.	Quercetin	43-52	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
21867678-0	2011	Quercetin-induced downregulation of phospholipase D1 inhibits proliferation and invasion in U87 glioma cells.	Quercetin	0-9	phospholipase D1	Homo sapiens	36-52
21867678-4	2011	In the present study, we examined the effect of quercetin on the expression of PLD in U87 glioma cells.	Quercetin	48-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	79-82
21867678-5	2011	Quercetin significantly suppressed the expression of PLD1 at the transcriptional level.	Quercetin	0-9	phospholipase D1	Homo sapiens	53-57
21867678-6	2011	Moreover, quercetin abolished the protein expression of PLD1 in a time and dose-dependent manner, as well as inhibited PLD activity.	Quercetin	10-19	phospholipase D1	Homo sapiens	56-60
21867678-6	2011	Moreover, quercetin abolished the protein expression of PLD1 in a time and dose-dependent manner, as well as inhibited PLD activity.	Quercetin	10-19	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	56-59
21867678-7	2011	Quercetin suppressed NFkappaB-induced PLD1 expression via inhibition of NFkB transactivation.	Quercetin	0-9	phospholipase D1	Homo sapiens	38-42
21867678-8	2011	Furthermore, quercetin inhibited activation and invasion of metalloproteinase-2 (MMP-2), a key modulator of glioma cell invasion, induced by phosphatidic acid (PA), a product of PLD activity.	Quercetin	13-22	matrix metallopeptidase 2	Homo sapiens	81-86
21867678-8	2011	Furthermore, quercetin inhibited activation and invasion of metalloproteinase-2 (MMP-2), a key modulator of glioma cell invasion, induced by phosphatidic acid (PA), a product of PLD activity.	Quercetin	13-22	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	178-181
21867678-9	2011	Taken together these data demonstrate that quercetin abolishes PLD1 expression and subsequently inhibits invasion and proliferation of glioma cells.	Quercetin	43-52	phospholipase D1	Homo sapiens	63-67
22186243-3	2011	Quercetin exhibits well-known antioxidant and anti-inflammatory activity and is now recognized as a potent activator of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel activity in a fashion largely independent of cyclic adenosine monophosphate signaling.	Quercetin	0-9	CF transmembrane conductance regulator	Homo sapiens	124-175
22186243-3	2011	Quercetin exhibits well-known antioxidant and anti-inflammatory activity and is now recognized as a potent activator of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel activity in a fashion largely independent of cyclic adenosine monophosphate signaling.	Quercetin	0-9	CF transmembrane conductance regulator	Homo sapiens	177-181
22186243-7	2011	CBF was significantly increased in quercetin-treated cells (expressed as fold change over baseline) in wild type (1.65 +- 0.13 versus 1.23 +- 0.05 [control]; p &lt; 0.01), but not CFTR(-/-) (1.65 +- 0.29 versus 1.48 +- 0.38; p = 0.23).	Quercetin	35-44	CF transmembrane conductance regulator	Homo sapiens	180-184
21605637-3	2011	Compared with the high glucose group, quercetin may decrease the cell percentages of G(0)/G(1) phase, Smad 2/3 expression, laminin and type IV collagen, and TGF-beta(1) mRNA level significantly.	Quercetin	38-47	SMAD family member 2	Rattus norvegicus	102-110
21600261-2	2011	In the present study, we assessed the effects of the flavonoids Genistein, Apigenin, Quercetin, Rutin and Astilbin on xanthine oxidase (XO) activities in vitro, and in serum and the liver.	Quercetin	85-94	xanthine dehydrogenase	Mus musculus	118-134
21605637-3	2011	Compared with the high glucose group, quercetin may decrease the cell percentages of G(0)/G(1) phase, Smad 2/3 expression, laminin and type IV collagen, and TGF-beta(1) mRNA level significantly.	Quercetin	38-47	transforming growth factor, beta 1	Rattus norvegicus	157-168
21605637-4	2011	The antioxidant capacity, the cell percentages of S phase and Smad 7 expression was significantly increased by quercetin.	Quercetin	111-120	SMAD family member 7	Rattus norvegicus	62-68
21664865-13	2011	Decreased expression of eNOS in diabetic rats was only ameliorated by 50mg/kg quercetin treatment.	Quercetin	78-87	nitric oxide synthase 3	Rattus norvegicus	24-28
21902895-0	2011	Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells.	Quercetin	0-9	telomerase reverse transcriptase	Homo sapiens	47-52
21902895-4	2011	The effects of quercetin on telomerase enzyme activity were shown by hTERT Quantification Kit.	Quercetin	15-24	telomerase reverse transcriptase	Homo sapiens	69-74
21638315-0	2011	A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: the role of aryl hydrocarbon receptor as a mediator of osteogenic action.	Quercetin	8-17	aryl hydrocarbon receptor	Rattus norvegicus	180-205
21455760-0	2011	Binding of quercetin to lysozyme as probed by spectroscopic analysis and molecular simulation.	Quercetin	11-20	lysozyme	Homo sapiens	24-32
21832258-4	2011	The non-CYP3A4 inhibitors diethyldithiocarbamate, quercetin, quinidine, sulfaphenazole, ticlopidine, and tranylcypromine were found to have substantially lower (maximum inhibition of &lt;50%) or no apparent inhibitory effects in the HTS assay.	Quercetin	50-59	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	8-14
21455760-1	2011	The binding of quercetin to lysozyme (LYSO) in aqueous solution was investigated by fluorescence spectroscopy, UV-vis absorption spectroscopy and molecular simulation at pH 7.4.	Quercetin	15-24	lysozyme	Homo sapiens	28-36
21805050-6	2011	Furthermore, we observed that quercetin induced the loss of mitochondrial membrane potential, upregulated the expression of the proapoptotic proteins, Bax and cytochrome C, and activated caspase-9 and caspase-3, and downregulated the expression of antiapoptotic protein, Bcl-2.	Quercetin	30-39	BCL2 associated X, apoptosis regulator	Homo sapiens	151-154
21805050-6	2011	Furthermore, we observed that quercetin induced the loss of mitochondrial membrane potential, upregulated the expression of the proapoptotic proteins, Bax and cytochrome C, and activated caspase-9 and caspase-3, and downregulated the expression of antiapoptotic protein, Bcl-2.	Quercetin	30-39	cytochrome c, somatic	Homo sapiens	159-171
21805050-6	2011	Furthermore, we observed that quercetin induced the loss of mitochondrial membrane potential, upregulated the expression of the proapoptotic proteins, Bax and cytochrome C, and activated caspase-9 and caspase-3, and downregulated the expression of antiapoptotic protein, Bcl-2.	Quercetin	30-39	caspase 9	Homo sapiens	187-196
21805050-6	2011	Furthermore, we observed that quercetin induced the loss of mitochondrial membrane potential, upregulated the expression of the proapoptotic proteins, Bax and cytochrome C, and activated caspase-9 and caspase-3, and downregulated the expression of antiapoptotic protein, Bcl-2.	Quercetin	30-39	caspase 3	Homo sapiens	201-210
21805050-6	2011	Furthermore, we observed that quercetin induced the loss of mitochondrial membrane potential, upregulated the expression of the proapoptotic proteins, Bax and cytochrome C, and activated caspase-9 and caspase-3, and downregulated the expression of antiapoptotic protein, Bcl-2.	Quercetin	30-39	BCL2 apoptosis regulator	Homo sapiens	271-276
21617882-9	2011	Taken together, our results demonstrate that quercetin-induced apoptosis in the MTX-resistant osteosarcoma cells U2-OS/MTX300 was mediated via mitochondrial dysfunction and dephosphorylation of Akt.	Quercetin	45-54	AKT serine/threonine kinase 1	Homo sapiens	194-197
21756928-6	2011	Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes.	Quercetin	17-26	epidermal growth factor receptor	Homo sapiens	47-51
21617882-0	2011	Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	149-152
21617882-6	2011	Quercetin-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to the cytosol, activation of caspase-3, down-regulation of Bcl-2, p-Bad and up-regulation of Bax.	Quercetin	0-9	cytochrome c, somatic	Homo sapiens	133-145
21617882-6	2011	Quercetin-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to the cytosol, activation of caspase-3, down-regulation of Bcl-2, p-Bad and up-regulation of Bax.	Quercetin	0-9	caspase 3	Homo sapiens	176-185
21617882-6	2011	Quercetin-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to the cytosol, activation of caspase-3, down-regulation of Bcl-2, p-Bad and up-regulation of Bax.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	206-211
21617882-6	2011	Quercetin-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to the cytosol, activation of caspase-3, down-regulation of Bcl-2, p-Bad and up-regulation of Bax.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	240-243
21617882-7	2011	A remarkable dephospho-rylation of Akt was also detected after quercetin treatment.	Quercetin	63-72	AKT serine/threonine kinase 1	Homo sapiens	35-38
21617882-8	2011	Furthermore, transduction with constitutively active Akt protected against the quercetin-induced dephosphorylation of Akt and Bad as well as poly(ADP-ribose)polymerase (PARP) degradation, while combined treatment with quercetin and LY294002 enhanced the dephosphorylation of Akt, Bad and PARP cleavage in U2-OS/MTX300 cells.	Quercetin	79-88	AKT serine/threonine kinase 1	Homo sapiens	53-56
21617882-8	2011	Furthermore, transduction with constitutively active Akt protected against the quercetin-induced dephosphorylation of Akt and Bad as well as poly(ADP-ribose)polymerase (PARP) degradation, while combined treatment with quercetin and LY294002 enhanced the dephosphorylation of Akt, Bad and PARP cleavage in U2-OS/MTX300 cells.	Quercetin	79-88	AKT serine/threonine kinase 1	Homo sapiens	118-121
21617882-8	2011	Furthermore, transduction with constitutively active Akt protected against the quercetin-induced dephosphorylation of Akt and Bad as well as poly(ADP-ribose)polymerase (PARP) degradation, while combined treatment with quercetin and LY294002 enhanced the dephosphorylation of Akt, Bad and PARP cleavage in U2-OS/MTX300 cells.	Quercetin	79-88	poly(ADP-ribose) polymerase 1	Homo sapiens	141-167
21617882-8	2011	Furthermore, transduction with constitutively active Akt protected against the quercetin-induced dephosphorylation of Akt and Bad as well as poly(ADP-ribose)polymerase (PARP) degradation, while combined treatment with quercetin and LY294002 enhanced the dephosphorylation of Akt, Bad and PARP cleavage in U2-OS/MTX300 cells.	Quercetin	79-88	poly(ADP-ribose) polymerase 1	Homo sapiens	169-173
21617882-8	2011	Furthermore, transduction with constitutively active Akt protected against the quercetin-induced dephosphorylation of Akt and Bad as well as poly(ADP-ribose)polymerase (PARP) degradation, while combined treatment with quercetin and LY294002 enhanced the dephosphorylation of Akt, Bad and PARP cleavage in U2-OS/MTX300 cells.	Quercetin	79-88	AKT serine/threonine kinase 1	Homo sapiens	118-121
21617882-8	2011	Furthermore, transduction with constitutively active Akt protected against the quercetin-induced dephosphorylation of Akt and Bad as well as poly(ADP-ribose)polymerase (PARP) degradation, while combined treatment with quercetin and LY294002 enhanced the dephosphorylation of Akt, Bad and PARP cleavage in U2-OS/MTX300 cells.	Quercetin	79-88	poly(ADP-ribose) polymerase 1	Homo sapiens	288-292
21617882-8	2011	Furthermore, transduction with constitutively active Akt protected against the quercetin-induced dephosphorylation of Akt and Bad as well as poly(ADP-ribose)polymerase (PARP) degradation, while combined treatment with quercetin and LY294002 enhanced the dephosphorylation of Akt, Bad and PARP cleavage in U2-OS/MTX300 cells.	Quercetin	218-227	AKT serine/threonine kinase 1	Homo sapiens	53-56
21617882-8	2011	Furthermore, transduction with constitutively active Akt protected against the quercetin-induced dephosphorylation of Akt and Bad as well as poly(ADP-ribose)polymerase (PARP) degradation, while combined treatment with quercetin and LY294002 enhanced the dephosphorylation of Akt, Bad and PARP cleavage in U2-OS/MTX300 cells.	Quercetin	218-227	poly(ADP-ribose) polymerase 1	Homo sapiens	141-167
21756928-6	2011	Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes.	Quercetin	17-26	aryl hydrocarbon receptor	Homo sapiens	86-111
21756928-6	2011	Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes.	Quercetin	17-26	aryl hydrocarbon receptor	Homo sapiens	113-116
21756928-6	2011	Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes.	Quercetin	17-26	epidermal growth factor receptor	Homo sapiens	192-196
21756928-6	2011	Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes.	Quercetin	17-26	aryl hydrocarbon receptor	Homo sapiens	235-238
21861917-6	2011	CONCLUSION: In conclusion, antioxidant quercetin could protect against Dimethoate-induced oxidative stress by decreasing lipid peroxidation, protein oxidation and increasing superoxide dismutase and catalase activities in human lymphocytes.	Quercetin	39-48	catalase	Homo sapiens	199-207
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	Quercetin	12-21	intercellular adhesion molecule 1	Homo sapiens	133-166
21775671-7	2011	Induction of CYP9Q2 and CYP9Q3 transcripts by honey extracts suggested that diet-derived phytochemicals may be natural substrates and heterologous expression of CYP9Q3 confirmed activity against quercetin, a flavonoid ubiquitous in honey.	Quercetin	195-204	cytochrome P450 9e2	Apis mellifera	13-19
21775671-7	2011	Induction of CYP9Q2 and CYP9Q3 transcripts by honey extracts suggested that diet-derived phytochemicals may be natural substrates and heterologous expression of CYP9Q3 confirmed activity against quercetin, a flavonoid ubiquitous in honey.	Quercetin	195-204	cytochrome P450 9e2	Apis mellifera	24-30
21775671-7	2011	Induction of CYP9Q2 and CYP9Q3 transcripts by honey extracts suggested that diet-derived phytochemicals may be natural substrates and heterologous expression of CYP9Q3 confirmed activity against quercetin, a flavonoid ubiquitous in honey.	Quercetin	195-204	cytochrome P450 9e2	Apis mellifera	161-167
21543555-1	2011	UDP-glucuronosyltransferase (UGT) activity toward the flavonoid quercetin and UGT protein were characterized in three equidistant small intestine (SI) segments from 4-, 12-, 18-, and 28-month-old male Fischer 344 rats (n = 8/age) using villin to control for enterocyte content.	Quercetin	64-73	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-27
21543555-1	2011	UDP-glucuronosyltransferase (UGT) activity toward the flavonoid quercetin and UGT protein were characterized in three equidistant small intestine (SI) segments from 4-, 12-, 18-, and 28-month-old male Fischer 344 rats (n = 8/age) using villin to control for enterocyte content.	Quercetin	64-73	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	29-32
21543555-4	2011	Quercetin UGT regioselectivity was not changed by age.	Quercetin	0-9	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	10-13
21543555-9	2011	Microsomal rates of quercetin glucuronidation and UGT expression were positively correlated with UGT1A1 content for all pooled samples (r = 0.467) and at each age (r = 0.538-0.598).	Quercetin	20-29	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	97-103
21543555-11	2011	Thus, age-related differences in UGT quercetin glucuronidation depend on intestinal segment, are more pronounced in the proximal and distal segments and may be partially related to UGT1A1 and UGT1A7 content.	Quercetin	37-46	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	33-36
21543555-11	2011	Thus, age-related differences in UGT quercetin glucuronidation depend on intestinal segment, are more pronounced in the proximal and distal segments and may be partially related to UGT1A1 and UGT1A7 content.	Quercetin	37-46	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	181-187
21543555-11	2011	Thus, age-related differences in UGT quercetin glucuronidation depend on intestinal segment, are more pronounced in the proximal and distal segments and may be partially related to UGT1A1 and UGT1A7 content.	Quercetin	37-46	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	192-198
21290442-0	2011	Quercetin inhibits alpha-MSH-stimulated melanogenesis in B16F10 melanoma cells.	Quercetin	0-9	pro-opiomelanocortin-alpha	Mus musculus	19-28
21290442-1	2011	Quercetin is known to inhibit tyrosinase activity and melanin production in melanocytes.	Quercetin	0-9	tyrosinase	Mus musculus	30-40
21290442-4	2011	Quercetin inhibited the monophenolase and diphenolase activities of tyrosinase, and melanin synthesis in cell-free assay systems.	Quercetin	0-9	tyrosinase	Mus musculus	68-78
21290442-5	2011	Quercetin induced mild stimulation of the tyrosinase activity and dihydroxyphenylalaminechrome tautomerase (TRP-2) expression but only at low concentrations (&lt;20 mum) in B16F10 melanoma cells.	Quercetin	0-9	tyrosinase	Mus musculus	42-52
21290442-5	2011	Quercetin induced mild stimulation of the tyrosinase activity and dihydroxyphenylalaminechrome tautomerase (TRP-2) expression but only at low concentrations (&lt;20 mum) in B16F10 melanoma cells.	Quercetin	0-9	tRNA proline 2	Mus musculus	108-113
21290442-6	2011	In contrast, the addition of 50 mum quercetin to the cells led to a significant decrease in the activity and synthesis of tyrosinase, as well as a decrease in the expression of tyrosinase-related protein-1 and TRP-2 proteins, regardless of the presence or absence of alpha-melanocyte stimulating hormone (alpha-MSH).	Quercetin	36-45	tyrosinase	Mus musculus	122-132
21290442-6	2011	In contrast, the addition of 50 mum quercetin to the cells led to a significant decrease in the activity and synthesis of tyrosinase, as well as a decrease in the expression of tyrosinase-related protein-1 and TRP-2 proteins, regardless of the presence or absence of alpha-melanocyte stimulating hormone (alpha-MSH).	Quercetin	36-45	tyrosinase-related protein 1	Mus musculus	177-205
21290442-6	2011	In contrast, the addition of 50 mum quercetin to the cells led to a significant decrease in the activity and synthesis of tyrosinase, as well as a decrease in the expression of tyrosinase-related protein-1 and TRP-2 proteins, regardless of the presence or absence of alpha-melanocyte stimulating hormone (alpha-MSH).	Quercetin	36-45	tRNA proline 2	Mus musculus	210-215
21290442-6	2011	In contrast, the addition of 50 mum quercetin to the cells led to a significant decrease in the activity and synthesis of tyrosinase, as well as a decrease in the expression of tyrosinase-related protein-1 and TRP-2 proteins, regardless of the presence or absence of alpha-melanocyte stimulating hormone (alpha-MSH).	Quercetin	36-45	pro-opiomelanocortin-alpha	Mus musculus	267-303
21290442-6	2011	In contrast, the addition of 50 mum quercetin to the cells led to a significant decrease in the activity and synthesis of tyrosinase, as well as a decrease in the expression of tyrosinase-related protein-1 and TRP-2 proteins, regardless of the presence or absence of alpha-melanocyte stimulating hormone (alpha-MSH).	Quercetin	36-45	pro-opiomelanocortin-alpha	Mus musculus	305-314
21290442-7	2011	Quercetin also reduced the intracellular cAMP and the phosphorylated protein kinase A levels in alpha-MSH-stimulated B16F10 cells.	Quercetin	0-9	pro-opiomelanocortin-alpha	Mus musculus	96-105
21290442-8	2011	Moreover, quercetin (20 mum) diminished the expression and activity of tyrosinase, and melanin content in cultured normal human epidermal melanocytes.	Quercetin	10-19	tyrosinase	Homo sapiens	71-81
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	Quercetin	12-21	vascular cell adhesion molecule 1	Homo sapiens	398-431
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	Quercetin	12-21	vascular cell adhesion molecule 1	Homo sapiens	433-439
21571063-7	2011	In contrast, quercetin-3-O-glucuronide (20-100 muM), quercetin-3"-O-sulfate (10-30 muM), and phenolic acid metabolites of quercetin (20-100 muM) did not inhibit adhesion molecule expression.	Quercetin	13-22	latexin	Homo sapiens	47-50
21613575-6	2011	Gastrointestinal barrier permeability and TNF-alpha were increased on the 1st day of exercise/heat stress in quercetin; no differences in these variables were reported in placebo.	Quercetin	109-118	tumor necrosis factor	Homo sapiens	42-51
21472457-3	2011	Male Wistar rats were subjected to transient middle cerebral artery occlusion (MCAO) for 2 h and reperfused for 72 h. Quercetin (30 mg/kg, i.p) was administrated 30 min before the onset of ischemia and after the ischemia at interval of 0, 24, 48, and 72 h. The administration of Q showed marked reduction in infarct size, reduced the neurological deficits in terms of behaviors, suppressed neuronal loss and diminished the p53 expression in MCAO rats.	Quercetin	118-127	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	423-426
21472459-1	2011	The present study is aimed to evaluate the putative neuroprotective effect of quercetin on PCB induced impairment of dopaminergic receptor mRNA expression in cerebral cortex of adult male Wistar rats.	Quercetin	78-87	pyruvate carboxylase	Rattus norvegicus	91-94
21472459-6	2011	Results evidenced that significant reduction of neurodegeneration in PCBs exposed rats treated with quercetin was ascertained suggesting, quercetin treatment precludes against PCB induced oxidative stress and protects dopaminergic receptor dysfunction in rat cerebral cortex.	Quercetin	100-109	pyruvate carboxylase	Rattus norvegicus	69-72
21472459-6	2011	Results evidenced that significant reduction of neurodegeneration in PCBs exposed rats treated with quercetin was ascertained suggesting, quercetin treatment precludes against PCB induced oxidative stress and protects dopaminergic receptor dysfunction in rat cerebral cortex.	Quercetin	138-147	pyruvate carboxylase	Rattus norvegicus	69-72
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	Quercetin	12-21	intercellular adhesion molecule 1	Homo sapiens	168-174
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	Quercetin	12-21	latexin	Homo sapiens	260-263
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	Quercetin	12-21	selectin E	Homo sapiens	279-289
21371861-7	2011	RESULTS: Quercetin (but not Q3GA) decreased the production of 5-HIAL by MAO-A activity.	Quercetin	9-18	monoamine oxidase A	Mus musculus	72-77
21750559-0	2011	Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation.	Quercetin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	24-29
21750559-1	2011	BACKGROUND: We recently demonstrated that quercetin, a flavonoid naturally present in food and beverages belonging to the large class of phytochemicals, was able to sensitise leukaemic cells isolated from patients with chronic lymphocytic leukaemia (CLL) when associated with recombinant tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) or anti-CD95.	Quercetin	42-51	TNF superfamily member 10	Homo sapiens	288-344
21750559-1	2011	BACKGROUND: We recently demonstrated that quercetin, a flavonoid naturally present in food and beverages belonging to the large class of phytochemicals, was able to sensitise leukaemic cells isolated from patients with chronic lymphocytic leukaemia (CLL) when associated with recombinant tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) or anti-CD95.	Quercetin	42-51	TNF superfamily member 10	Homo sapiens	346-351
21750559-1	2011	BACKGROUND: We recently demonstrated that quercetin, a flavonoid naturally present in food and beverages belonging to the large class of phytochemicals, was able to sensitise leukaemic cells isolated from patients with chronic lymphocytic leukaemia (CLL) when associated with recombinant tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) or anti-CD95.	Quercetin	42-51	Fas cell surface death receptor	Homo sapiens	361-365
21750559-7	2011	Quercetin significantly enhanced the downregulation of Mcl-1 in B cells isolated from selected patients expressing detectable levels of Mcl-1.	Quercetin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	55-60
21750559-7	2011	Quercetin significantly enhanced the downregulation of Mcl-1 in B cells isolated from selected patients expressing detectable levels of Mcl-1.	Quercetin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	136-141
21750559-8	2011	In U-937 cells, quercetin increased Mcl-1 mRNA instability in the presence of actinomycin D.	Quercetin	16-25	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	36-41
21750559-10	2011	However, quercetin, in the presence of Z-Vad-FMK, continued to lower Mcl-1 protein expression, indicating its independence from caspase-mediated degradation.	Quercetin	9-18	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	69-74
21750559-11	2011	In contrast, co-treatment of quercetin and MG-132 did not revert the effect of MG-132 mono-treatment, thus suggesting a possible interference of quercetin in regulating the proteasome-dependent degradation of Mcl-1.	Quercetin	145-154	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	209-214
21750559-12	2011	Gossypol, a small-molecule inhibitor of Bcl-2 family members, mimics the activity of quercetin by lowering Mcl-1 expression and sensitising U-937 cells to apoptosis induced by recombinant TRAIL and the Fas-ligand.	Quercetin	85-94	BCL2 apoptosis regulator	Homo sapiens	40-45
21750559-12	2011	Gossypol, a small-molecule inhibitor of Bcl-2 family members, mimics the activity of quercetin by lowering Mcl-1 expression and sensitising U-937 cells to apoptosis induced by recombinant TRAIL and the Fas-ligand.	Quercetin	85-94	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	107-112
21750559-12	2011	Gossypol, a small-molecule inhibitor of Bcl-2 family members, mimics the activity of quercetin by lowering Mcl-1 expression and sensitising U-937 cells to apoptosis induced by recombinant TRAIL and the Fas-ligand.	Quercetin	85-94	TNF superfamily member 10	Homo sapiens	188-193
21750559-13	2011	CONCLUSION: This study demonstrates that in U-937 cells, quercetin downregulates Mcl-1 acting directly or indirectly on its mRNA stability and protein degradation, suggesting that the same mechanism may bypass resistance to apoptosis in leukaemic cells isolated from CLL patients and sensitise B cells to apoptosis induced by drugs and death receptor inducers.	Quercetin	57-66	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	81-86
21562239-0	2011	Suppression of amphiregulin/epidermal growth factor receptor signals contributes to the protective effects of quercetin in cirrhotic rats.	Quercetin	110-119	amphiregulin	Rattus norvegicus	15-27
21562239-0	2011	Suppression of amphiregulin/epidermal growth factor receptor signals contributes to the protective effects of quercetin in cirrhotic rats.	Quercetin	110-119	epidermal growth factor receptor	Rattus norvegicus	28-60
21371861-0	2011	Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria.	Quercetin	10-19	monoamine oxidase A	Mus musculus	55-74
21371861-4	2011	The effect of quercetin and its antioxidative metabolite quercetin 3-glucuronide (Q3GA) on the activity of mouse brain mitochondrial monoamine oxidase-A (MAO-A) was evaluated by measuring the deamination product of serotonin, 5-hydroxyindole acetaldehyde (5-HIAL).	Quercetin	14-23	monoamine oxidase A	Mus musculus	133-152
21371861-4	2011	The effect of quercetin and its antioxidative metabolite quercetin 3-glucuronide (Q3GA) on the activity of mouse brain mitochondrial monoamine oxidase-A (MAO-A) was evaluated by measuring the deamination product of serotonin, 5-hydroxyindole acetaldehyde (5-HIAL).	Quercetin	14-23	monoamine oxidase A	Mus musculus	154-159
21371861-6	2011	The inhibitory effect of quercetin and Q3GA on mitochondrial MAO-A activity was estimated by the content of 5-HIAL and hydrogen peroxide accompanied by the MAO-A reaction.	Quercetin	25-34	monoamine oxidase A	Mus musculus	61-66
21371861-6	2011	The inhibitory effect of quercetin and Q3GA on mitochondrial MAO-A activity was estimated by the content of 5-HIAL and hydrogen peroxide accompanied by the MAO-A reaction.	Quercetin	25-34	monoamine oxidase A	Mus musculus	156-161
21738342-6	2011	The thyroid cancer cell lines, TPC-1, FTC-133, NPA, FRO, and ARO, displayed growth inhibition in response to genistein, resveratrol, quercetin.	Quercetin	133-142	two pore segment channel 1	Homo sapiens	31-36
21738342-6	2011	The thyroid cancer cell lines, TPC-1, FTC-133, NPA, FRO, and ARO, displayed growth inhibition in response to genistein, resveratrol, quercetin.	Quercetin	133-142	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	61-64
21371861-10	2011	Brain mitochondrial MAO-A activity was decreased in mice administered quercetin for 7 d, but its effect was much weaker than that of the selective MAO-A inhibitor clorgyline.	Quercetin	70-79	monoamine oxidase A	Mus musculus	20-25
21226126-6	2011	Hirsutrin, avicularin and quercetin (10 muM) showed clear hepatoprotective activity against injury by t-BHP in HepG2 cells, whereas isovitexin and trifolin showed no protective effects.	Quercetin	26-35	latexin	Homo sapiens	40-43
21371861-10	2011	Brain mitochondrial MAO-A activity was decreased in mice administered quercetin for 7 d, but its effect was much weaker than that of the selective MAO-A inhibitor clorgyline.	Quercetin	70-79	monoamine oxidase A	Mus musculus	147-152
21371861-11	2011	CONCLUSION: Quercetin is effective in the modulation of serotonergic activity by attenuating mitochondrial MAO-A activity in the brain.	Quercetin	12-21	monoamine oxidase A	Mus musculus	107-112
21267808-0	2011	Plasma rich in quercetin metabolites induces G2/M arrest by upregulating PPAR-gamma expression in human A549 lung cancer cells.	Quercetin	15-24	peroxisome proliferator activated receptor gamma	Homo sapiens	73-83
21267808-5	2011	QMP but not CP or quercetin itself significantly increased PPAR- gamma expression (p &lt; 0.05), which was accompanied by an increase of phosphatase and tensin homologue deleted on the chromosome ten level and a decrease of phosphorylation of Akt.	Quercetin	18-27	peroxisome proliferator activated receptor gamma	Homo sapiens	59-70
21267808-8	2011	Taken together, these data suggest that the activation of PPAR- gamma plays an important role, at least in part, in the antiproliferative effects of quercetin metabolites.	Quercetin	149-158	peroxisome proliferator activated receptor gamma	Homo sapiens	58-69
21418708-8	2011	The increase in SVCT1 expression correlated with an increase in ascorbic acid uptake (285 %) in Fe-treated cells, as indicated by the SVCT1 inhibitor quercetin.	Quercetin	150-159	solute carrier family 23 member 1	Homo sapiens	16-21
21418708-8	2011	The increase in SVCT1 expression correlated with an increase in ascorbic acid uptake (285 %) in Fe-treated cells, as indicated by the SVCT1 inhibitor quercetin.	Quercetin	150-159	solute carrier family 23 member 1	Homo sapiens	134-139
21598989-8	2011	Further, we found that quercetin and curcumin induced growth arrest by inhibition of Skp2, and induced p27 expression in MDA-MB-231 cells.	Quercetin	23-32	S-phase kinase associated protein 2	Homo sapiens	85-89
21598989-0	2011	1,2,3,4,6-penta-O-galloyl-beta-D-glucose, quercetin, curcumin and lycopene induce cell-cycle arrest in MDA-MB-231 and BT474 cells through downregulation of Skp2 protein.	Quercetin	42-51	S-phase kinase associated protein 2	Homo sapiens	156-160
21598989-8	2011	Further, we found that quercetin and curcumin induced growth arrest by inhibition of Skp2, and induced p27 expression in MDA-MB-231 cells.	Quercetin	23-32	interferon alpha inducible protein 27	Homo sapiens	103-106
21598989-12	2011	Furthermore, our results reveal that FoxO1 protein was increased after 5gg, quercetin, curcumin and lycopene treatment.	Quercetin	76-85	forkhead box O1	Homo sapiens	37-42
21272192-4	2011	Cell incubation with antioxidants quercetin or genistein prevents 24-hydroxycholesterol"s pro-oxidant effect and potentiation of Abeta-induced necrosis and apoptosis.	Quercetin	34-43	amyloid beta precursor protein	Homo sapiens	129-134
21120545-7	2011	FINDINGS: Quercetin treatment markedly reduced ischemia-induced up-regulation of MMP-9 at 24 and 48 h after ischemic injury.	Quercetin	10-19	matrix metallopeptidase 9	Rattus norvegicus	81-86
21216973-0	2011	Attenuation of transforming growth factor-beta-stimulated collagen production in fibroblasts by quercetin-induced heme oxygenase-1.	Quercetin	96-105	heme oxygenase 1	Mus musculus	114-130
21120545-11	2011	CONCLUSIONS: The results of this study demonstrated that quercetin attenuated BBB disruption during focal ischemia through inhibitory effects on MMP-9 activity.	Quercetin	57-66	matrix metallopeptidase 9	Rattus norvegicus	145-150
21507333-0	2011	Evaluation of the effects of Quercetin and Kaempherol on the surface of MT-2 cells visualized by atomic force microscopy.	Quercetin	29-38	metallothionein 2A	Homo sapiens	72-76
21507333-1	2011	This study investigated the anti-viral effects of the polyphenolic compounds Quercetin and Kaempherol on the release of HTLV-1 from the surface of MT-2 cells.	Quercetin	77-86	metallothionein 2A	Homo sapiens	147-151
21507333-6	2011	Interestingly, cell-free viruses and budding structures visualized on the surface of cells were less common when MT-2 was incubated with Quercetin, and no particles were seen on the surface of cells incubated with Kaempherol.	Quercetin	137-146	metallothionein 2A	Homo sapiens	113-117
21586116-3	2011	The current study presents a single molecule of bovine serum albumin (BSA), lysozyme (Lys), or myoglobin (Mb) used to load hydrophobic drugs such as quercetin (Q) and other flavonoids.	Quercetin	149-158	lysozyme	Homo sapiens	76-84
21586116-3	2011	The current study presents a single molecule of bovine serum albumin (BSA), lysozyme (Lys), or myoglobin (Mb) used to load hydrophobic drugs such as quercetin (Q) and other flavonoids.	Quercetin	149-158	myoglobin	Homo sapiens	95-104
21466223-0	2011	Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	118-132
21466223-0	2011	Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4.	Quercetin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	137-144
21466223-7	2011	The in vitro studies indicated that the quercetin and rutin induced the functions of P-gp and CYP3A4.	Quercetin	40-49	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
21466223-7	2011	The in vitro studies indicated that the quercetin and rutin induced the functions of P-gp and CYP3A4.	Quercetin	40-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	94-100
21466223-8	2011	In conclusion, quercetin and rutin decreased the bioavailability of CSP through activating P-gp and CYP3A.	Quercetin	15-24	ATP binding cassette subfamily B member 1	Homo sapiens	91-95
21699081-4	2011	To evaluate the impact of the biotransformation of Citrus flavonoids on the P-gp inhibition, the inhibitory effects of quercetin and its metabolite on P-gp were compared using ex vivo analysis.	Quercetin	119-128	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	151-155
21463675-12	2011	The isolated compounds showed estrogenic activity but quercetin, kaempferol and isorhamnetin showed more potent ERbeta agonist activity.	Quercetin	54-63	estrogen receptor 2	Rattus norvegicus	112-118
21463675-13	2011	However, compared with their ER agonist activity, only quercetin and kaempferol showed potent ER antagonist activity by activating ERalpha/beta-mediated AP-1 reporter expression.	Quercetin	55-64	estrogen receptor 1	Homo sapiens	131-138
21466223-8	2011	In conclusion, quercetin and rutin decreased the bioavailability of CSP through activating P-gp and CYP3A.	Quercetin	15-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	100-105
21216973-4	2011	Furthermore, quercetin was reported to be a potent inducer of HO-1 in several cell types.	Quercetin	13-22	heme oxygenase 1	Mus musculus	62-66
21216973-5	2011	We hypothesized that quercetin suppresses the production of collagen in fibroblasts via the induction of HO-1.	Quercetin	21-30	heme oxygenase 1	Mus musculus	105-109
21216973-7	2011	This suppressive effect of quercetin was mediated by quercetin-induced HO-1.	Quercetin	27-36	heme oxygenase 1	Mus musculus	71-75
21216973-7	2011	This suppressive effect of quercetin was mediated by quercetin-induced HO-1.	Quercetin	53-62	heme oxygenase 1	Mus musculus	71-75
21216973-9	2011	Furthermore, the translocation of the nuclear factor E2-related factor-2 (Nrf2), an important transcription factor that regulates the expression of HO-1 from the cytoplasm to the nuclei, was demonstrated in NIH3T3 cells by exposure to quercetin.	Quercetin	235-244	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78
21216973-9	2011	Furthermore, the translocation of the nuclear factor E2-related factor-2 (Nrf2), an important transcription factor that regulates the expression of HO-1 from the cytoplasm to the nuclei, was demonstrated in NIH3T3 cells by exposure to quercetin.	Quercetin	235-244	heme oxygenase 1	Mus musculus	148-152
21216973-11	2011	Our results demonstrate that quercetin exerts suppressive effects on the expression of collagen by the induction of HO-1.	Quercetin	29-38	heme oxygenase 1	Mus musculus	116-120
21216973-13	2011	Given that HO-1 is one of the important molecules emerging as a central player in diseases, quercetin or its derivatives, which effectively induced HO-1, will lead to new therapeutic strategies for promoting antifibrotic therapy in respiratory diseases.	Quercetin	92-101	heme oxygenase 1	Mus musculus	11-15
21216973-13	2011	Given that HO-1 is one of the important molecules emerging as a central player in diseases, quercetin or its derivatives, which effectively induced HO-1, will lead to new therapeutic strategies for promoting antifibrotic therapy in respiratory diseases.	Quercetin	92-101	heme oxygenase 1	Mus musculus	148-152
21080136-7	2011	To further investigate whether increase of HSP70 might be responsible for protection of the myocardium against I/R injury, we co-administered the HSP70 inhibitor, quercetin, with LPS before I/R injury.	Quercetin	163-172	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	43-48
21080136-7	2011	To further investigate whether increase of HSP70 might be responsible for protection of the myocardium against I/R injury, we co-administered the HSP70 inhibitor, quercetin, with LPS before I/R injury.	Quercetin	163-172	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	146-151
21499124-1	2011	As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands.	Quercetin	3-12	protein kinase C delta	Homo sapiens	109-112
21499124-1	2011	As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands.	Quercetin	3-12	killer cell lectin like receptor K1	Homo sapiens	180-185
21499124-1	2011	As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands.	Quercetin	3-12	epidermal growth factor receptor	Homo sapiens	284-316
21499124-1	2011	As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands.	Quercetin	3-12	epidermal growth factor receptor	Homo sapiens	318-322
21499124-1	2011	As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands.	Quercetin	3-12	killer cell lectin like receptor K1	Homo sapiens	359-364
21375526-12	2011	CONCLUSION AND IMPLICATIONS: Quercetin, quercetin 3"-suphate and quercetin 3-glucuronide, exerted anti-inflammatory effects on the vasculature, possibly through a mechanism involving inhibition of NFkappaB.	Quercetin	29-38	nuclear factor kappa B subunit 1	Homo sapiens	197-205
21488180-9	2011	TBK1 kinase can be a target for certain flavonoids such as EGCG, luteolin, quercetin, chrysin, and eriodictyol to regulate TRIF-dependent TLR pathways.	Quercetin	75-84	TANK binding kinase 1	Homo sapiens	0-4
21488180-9	2011	TBK1 kinase can be a target for certain flavonoids such as EGCG, luteolin, quercetin, chrysin, and eriodictyol to regulate TRIF-dependent TLR pathways.	Quercetin	75-84	TIR domain containing adaptor molecule 1	Homo sapiens	123-127
21262342-5	2011	However, simultaneous supplementation with 1 mug/ml quercetin protected granulosa cells against cadmium-induced cytotoxicity through attenuating lipid peroxidation, renewing antioxidant enzymes activities and alleviating apoptosis by modulating XIAP, BAX and BCL2 expression, and inhibiting caspase-3 activity.	Quercetin	52-61	baculoviral IAP repeat containing 8	Gallus gallus	245-249
21262342-5	2011	However, simultaneous supplementation with 1 mug/ml quercetin protected granulosa cells against cadmium-induced cytotoxicity through attenuating lipid peroxidation, renewing antioxidant enzymes activities and alleviating apoptosis by modulating XIAP, BAX and BCL2 expression, and inhibiting caspase-3 activity.	Quercetin	52-61	BCL2, apoptosis regulator	Gallus gallus	259-263
21262342-5	2011	However, simultaneous supplementation with 1 mug/ml quercetin protected granulosa cells against cadmium-induced cytotoxicity through attenuating lipid peroxidation, renewing antioxidant enzymes activities and alleviating apoptosis by modulating XIAP, BAX and BCL2 expression, and inhibiting caspase-3 activity.	Quercetin	52-61	caspase 3	Gallus gallus	291-300
21295016-8	2011	Moreover, the inducing effects of FLZ on HSP27, HSP70, and HSF1 were all blocked by quercetin, an inhibitor of HSP biosynthesis.	Quercetin	84-93	heat shock protein family B (small) member 1	Homo sapiens	41-46
21295016-8	2011	Moreover, the inducing effects of FLZ on HSP27, HSP70, and HSF1 were all blocked by quercetin, an inhibitor of HSP biosynthesis.	Quercetin	84-93	heat shock protein family A (Hsp70) member 4	Homo sapiens	48-53
21295016-8	2011	Moreover, the inducing effects of FLZ on HSP27, HSP70, and HSF1 were all blocked by quercetin, an inhibitor of HSP biosynthesis.	Quercetin	84-93	heat shock transcription factor 1	Homo sapiens	59-63
21295016-11	2011	However, the protective effects of FLZ against MPP(+) were significantly blocked by quercetin, which indicated that the cytoprotective action of FLZ against MPP(+)-induced apoptosis is at least partially mediated by its induction of HSP27/HSP70.	Quercetin	84-93	heat shock protein family B (small) member 1	Homo sapiens	233-238
21295016-11	2011	However, the protective effects of FLZ against MPP(+) were significantly blocked by quercetin, which indicated that the cytoprotective action of FLZ against MPP(+)-induced apoptosis is at least partially mediated by its induction of HSP27/HSP70.	Quercetin	84-93	heat shock protein family A (Hsp70) member 4	Homo sapiens	239-244
21544726-1	2011	Quercetin, a flavonoid, is an inhibitor of P-glycoprotein-mediated efflux transport, and its oxidative metabolism is catalyzed by CYP enzymes.	Quercetin	0-9	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	43-57
21544726-4	2011	The effects of quercetin on the P-glycoprotein (P-gp) and CYP3A4 activities were also evaluated.	Quercetin	15-24	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	32-46
21544726-6	2011	In addition, quercetin significantly enhanced the intracellular accumulation of rhodamine-123 in MCF-7/ADR cells overexpressing P-gp.	Quercetin	13-22	phosphoglycolate phosphatase	Homo sapiens	128-132
21544726-12	2011	These results suggest that the quercetin-induced increase in bioavailability of oral doxorubicin can be attributed to enhanced doxorubicin absorption in the gastrointestinal tract via quercetin-induced inhibition of P-gp and reduced first-pass metabolism of doxorubicin due to quercetin-induced inhibition of CYP3A in the small intestine and/or in the liver rather than reduced renal and/or hepatic elimination of doxorubicin.	Quercetin	31-40	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	216-220
21544726-12	2011	These results suggest that the quercetin-induced increase in bioavailability of oral doxorubicin can be attributed to enhanced doxorubicin absorption in the gastrointestinal tract via quercetin-induced inhibition of P-gp and reduced first-pass metabolism of doxorubicin due to quercetin-induced inhibition of CYP3A in the small intestine and/or in the liver rather than reduced renal and/or hepatic elimination of doxorubicin.	Quercetin	184-193	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	216-220
21544726-12	2011	These results suggest that the quercetin-induced increase in bioavailability of oral doxorubicin can be attributed to enhanced doxorubicin absorption in the gastrointestinal tract via quercetin-induced inhibition of P-gp and reduced first-pass metabolism of doxorubicin due to quercetin-induced inhibition of CYP3A in the small intestine and/or in the liver rather than reduced renal and/or hepatic elimination of doxorubicin.	Quercetin	184-193	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	216-220
21244849-2	2011	In this study, we examined the interaction between metabolites of quercetin and isoflavonoids found in vivo with human organic anion transporters 1 (OAT1) and 3 (OAT3) and their potential in attenuating OAT-induced cytotoxicity of adefovir.	Quercetin	66-75	solute carrier family 22 member 6	Homo sapiens	119-147
21244849-2	2011	In this study, we examined the interaction between metabolites of quercetin and isoflavonoids found in vivo with human organic anion transporters 1 (OAT1) and 3 (OAT3) and their potential in attenuating OAT-induced cytotoxicity of adefovir.	Quercetin	66-75	solute carrier family 22 member 6	Homo sapiens	149-153
21244849-2	2011	In this study, we examined the interaction between metabolites of quercetin and isoflavonoids found in vivo with human organic anion transporters 1 (OAT1) and 3 (OAT3) and their potential in attenuating OAT-induced cytotoxicity of adefovir.	Quercetin	66-75	solute carrier family 22 member 8	Homo sapiens	162-166
21779580-6	2011	Quercetin restrained the proliferation of aHSCs rather than quiescent HSCs and heptotcytes by inducing a G(1) arrest as examined by cell cycle analysis and evidenced by increased levels of p53, p21(CIP1/WAF1), as well as p27(KIP1), and decreased abundance of cyclins (D(1), D(2), A, E).	Quercetin	0-9	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	189-192
21425153-8	2011	In a mouse model of lung cancer, chemotherapy-induced cells increased in the antiapoptosis pathway, and quercetin, an inhibitor of Hsp27, combined with traditional chemotherapy was effective in blocking the pathway and in the treatment of lung tumors in vivo.	Quercetin	104-113	heat shock protein 1	Mus musculus	131-136
20652710-11	2011	RESULTS: Quercetin reduced DC adhesion (-42%; p &lt; 0.05) and expression of CD11a (-21%; p &lt; 0.05).	Quercetin	9-18	integrin subunit alpha L	Homo sapiens	77-82
20652710-12	2011	OxLDL-induced DC differentiation was partially inhibited by quercetin (BDCA-1-29%; BDCA-2-33%; p &lt; 0.05).	Quercetin	60-69	CD1c molecule	Homo sapiens	71-77
20652710-12	2011	OxLDL-induced DC differentiation was partially inhibited by quercetin (BDCA-1-29%; BDCA-2-33%; p &lt; 0.05).	Quercetin	60-69	C-type lectin domain family 4 member C	Homo sapiens	83-89
20652710-14	2011	The 4-week treatment with quercetin resulted in relevant plasma levels (2.47 mumol/L) and reduced BDCA-2 + DCs in the peripheral blood by 42% (p &lt; 0.05) as well as systemic levels of the NO-synthase inhibitor asymmetric dimethylarginine (-31%, p &lt; 0.05).	Quercetin	26-35	C-type lectin domain family 4 member C	Homo sapiens	98-104
21779580-6	2011	Quercetin restrained the proliferation of aHSCs rather than quiescent HSCs and heptotcytes by inducing a G(1) arrest as examined by cell cycle analysis and evidenced by increased levels of p53, p21(CIP1/WAF1), as well as p27(KIP1), and decreased abundance of cyclins (D(1), D(2), A, E).	Quercetin	0-9	KRAS proto-oncogene, GTPase	Rattus norvegicus	194-197
21779580-6	2011	Quercetin restrained the proliferation of aHSCs rather than quiescent HSCs and heptotcytes by inducing a G(1) arrest as examined by cell cycle analysis and evidenced by increased levels of p53, p21(CIP1/WAF1), as well as p27(KIP1), and decreased abundance of cyclins (D(1), D(2), A, E).	Quercetin	0-9	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	198-202
21779580-6	2011	Quercetin restrained the proliferation of aHSCs rather than quiescent HSCs and heptotcytes by inducing a G(1) arrest as examined by cell cycle analysis and evidenced by increased levels of p53, p21(CIP1/WAF1), as well as p27(KIP1), and decreased abundance of cyclins (D(1), D(2), A, E).	Quercetin	0-9	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	203-207
21779580-6	2011	Quercetin restrained the proliferation of aHSCs rather than quiescent HSCs and heptotcytes by inducing a G(1) arrest as examined by cell cycle analysis and evidenced by increased levels of p53, p21(CIP1/WAF1), as well as p27(KIP1), and decreased abundance of cyclins (D(1), D(2), A, E).	Quercetin	0-9	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	221-224
21779580-6	2011	Quercetin restrained the proliferation of aHSCs rather than quiescent HSCs and heptotcytes by inducing a G(1) arrest as examined by cell cycle analysis and evidenced by increased levels of p53, p21(CIP1/WAF1), as well as p27(KIP1), and decreased abundance of cyclins (D(1), D(2), A, E).	Quercetin	0-9	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	225-229
21779580-9	2011	Furthermore, quercetin might restrain HSC activation through reducing the levels of inflammatory cytokines (CXCL10, Midkine).	Quercetin	13-22	C-X-C motif chemokine ligand 10	Rattus norvegicus	108-114
21779580-9	2011	Furthermore, quercetin might restrain HSC activation through reducing the levels of inflammatory cytokines (CXCL10, Midkine).	Quercetin	13-22	midkine	Rattus norvegicus	116-123
21356360-6	2011	Administration of quercetin, which inhibits HSP70 and suppresses Akt phosphorylation significantly increased photoreceptor apoptosis.	Quercetin	18-27	heat shock protein 1B	Mus musculus	44-49
21247706-8	2011	Common flavonoids of honey like chrysin, genistein, biochanin, quercetin, kaempferol, and naringenin have found to interact with P-gp transporters.	Quercetin	63-72	ATP binding cassette subfamily B member 1	Homo sapiens	129-133
21211511-8	2011	Role of NOX-mediated ROS production was reaffirmed by the observation that the antioxidants, trolox, nordihydroguaiaretic acid (NDGA), quercetin and resveratrol downregulated cytokine-induced MMP-13 mRNA and protein expression.	Quercetin	135-144	matrix metallopeptidase 13	Homo sapiens	192-198
21443429-0	2011	Citrus flavonoids luteolin, apigenin, and quercetin inhibit glycogen synthase kinase-3beta enzymatic activity by lowering the interaction energy within the binding cavity.	Quercetin	42-51	glycogen synthase kinase 3 beta	Homo sapiens	60-90
21443429-3	2011	Of the 22 citrus compounds tested, the flavonoids luteolin, apigenin, and quercetin had the highest inhibitory effects on GSK-3beta, with 50% inhibitory values of 1.5, 1.9, and 2.0 muM, respectively.	Quercetin	74-83	glycogen synthase kinase 3 beta	Homo sapiens	122-131
21443429-3	2011	Of the 22 citrus compounds tested, the flavonoids luteolin, apigenin, and quercetin had the highest inhibitory effects on GSK-3beta, with 50% inhibitory values of 1.5, 1.9, and 2.0 muM, respectively.	Quercetin	74-83	latexin	Homo sapiens	181-184
21443429-5	2011	Luteolin, apigenin, and quercetin were predicted to fit within the binding pocket of GSK-3beta with low interaction energies (-76.4, -76.1, and -84.6 kcal mol(-1), respectively) and low complex energies (-718.1, -688.1, and -719.7 kcal mol(-1), respectively).	Quercetin	24-33	glycogen synthase kinase 3 beta	Homo sapiens	85-94
21462320-3	2011	Triglyceride levels in plasma, thiobarbituric acid-reactive substances (oxidative stress marker) and glutathione levels and peroxisome proliferator-activated receptor alpha expression in livers of mice fed with the Western diet were all improved after 8 wk feeding with quercetin.	Quercetin	270-279	peroxisome proliferator activated receptor alpha	Mus musculus	124-172
21462320-4	2011	After 20 wk, further reductions of visceral and liver fat accumulation and improved hyperglycemia, hyperinsulinemia, dyslipidemia and plasma adiponectin and TNFalpha levels in these mice fed with quercetin were observed.	Quercetin	196-205	adiponectin, C1Q and collagen domain containing	Mus musculus	141-152
21462320-4	2011	After 20 wk, further reductions of visceral and liver fat accumulation and improved hyperglycemia, hyperinsulinemia, dyslipidemia and plasma adiponectin and TNFalpha levels in these mice fed with quercetin were observed.	Quercetin	196-205	tumor necrosis factor	Mus musculus	157-165
21462320-6	2011	In mice fed with the control diet, quercetin did not affect body weight but reduces the plasma TNFalpha and hepatic thiobarbituric acid-reactive substance levels.	Quercetin	35-44	tumor necrosis factor	Mus musculus	95-103
21462320-7	2011	CONCLUSION: In mice fed with a Western diet, chronic dietary intake of quercetin reduces liver fat accumulation and improves systemic parameters related to metabolic syndrome, probably mainly through decreasing oxidative stress and reducing PPARalpha expression, and the subsequent reduced expression in the liver of genes related to steatosis.	Quercetin	71-80	peroxisome proliferator activated receptor alpha	Mus musculus	241-250
21256954-1	2011	As phytochemicals have the potential to counteract adverse effects of carcinogens we investigated the influence of the flavonoids quercetin and kaempferol on benzo[a]pyrene (BaP) mediated effects on human colon cancer cells, Caco-2.	Quercetin	130-139	prohibitin 2	Homo sapiens	174-177
21256954-3	2011	In contrast to kaempferol, BaP and quercetin efficiently induced CYP1A1, CYP1A2 and CYP1B1-mRNA in Caco-2 cells.	Quercetin	35-44	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	65-71
21256954-3	2011	In contrast to kaempferol, BaP and quercetin efficiently induced CYP1A1, CYP1A2 and CYP1B1-mRNA in Caco-2 cells.	Quercetin	35-44	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	73-79
21256954-3	2011	In contrast to kaempferol, BaP and quercetin efficiently induced CYP1A1, CYP1A2 and CYP1B1-mRNA in Caco-2 cells.	Quercetin	35-44	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	84-90
21256954-6	2011	Only quercetin was found to induce AhRR mRNA.	Quercetin	5-14	aryl hydrocarbon receptor repressor	Homo sapiens	35-39
21256954-10	2011	In summary, we show that quercetin supports AhR mediated effects.	Quercetin	25-34	aryl hydrocarbon receptor	Homo sapiens	44-47
21256954-12	2011	In conclusion, quercetin appears to have two faces, a flavonoid-like one and a PAH-like one which supports Ahr-mediated effects while kaempferol acts "just like a flavonoid".	Quercetin	15-24	aryl hydrocarbon receptor	Homo sapiens	107-110
21362404-9	2011	Matrix metalloproteinase-2 (MMP-2) activity and vascular endothelial growth factor (VEGF) expression decreased in rats bearing W256 treated with 10 mg/kg quercetin when compared with CTR.	Quercetin	154-163	matrix metallopeptidase 2	Rattus norvegicus	0-26
21362404-9	2011	Matrix metalloproteinase-2 (MMP-2) activity and vascular endothelial growth factor (VEGF) expression decreased in rats bearing W256 treated with 10 mg/kg quercetin when compared with CTR.	Quercetin	154-163	matrix metallopeptidase 2	Rattus norvegicus	28-33
21362404-9	2011	Matrix metalloproteinase-2 (MMP-2) activity and vascular endothelial growth factor (VEGF) expression decreased in rats bearing W256 treated with 10 mg/kg quercetin when compared with CTR.	Quercetin	154-163	vascular endothelial growth factor A	Rattus norvegicus	48-82
21362404-9	2011	Matrix metalloproteinase-2 (MMP-2) activity and vascular endothelial growth factor (VEGF) expression decreased in rats bearing W256 treated with 10 mg/kg quercetin when compared with CTR.	Quercetin	154-163	vascular endothelial growth factor A	Rattus norvegicus	84-88
21362404-10	2011	Thus, the inhibition of tumor growth, survival increase, decrease of MMP-2 and VEGF levels and reduction of cachexia in animals treated with quercetin strongly support the anticancer function of this flavonoid.	Quercetin	141-150	vascular endothelial growth factor A	Rattus norvegicus	79-83
21337715-10	2011	Additionally, quercetin protected germ cells from cadmium-induced apoptosis by downregulating the expression of Bax and caspase-3 and upregulating Bcl-XL expression.	Quercetin	14-23	BCL2-associated X protein	Mus musculus	112-115
21337715-10	2011	Additionally, quercetin protected germ cells from cadmium-induced apoptosis by downregulating the expression of Bax and caspase-3 and upregulating Bcl-XL expression.	Quercetin	14-23	caspase 3	Mus musculus	120-129
21337715-10	2011	Additionally, quercetin protected germ cells from cadmium-induced apoptosis by downregulating the expression of Bax and caspase-3 and upregulating Bcl-XL expression.	Quercetin	14-23	BCL2-like 1	Mus musculus	147-153
21356360-6	2011	Administration of quercetin, which inhibits HSP70 and suppresses Akt phosphorylation significantly increased photoreceptor apoptosis.	Quercetin	18-27	thymoma viral proto-oncogene 1	Mus musculus	65-68
21498710-7	2011	The addition of Cy or Qu to GSI promoted the decrease of Notch1 activation and expression.	Quercetin	22-24	notch receptor 1	Homo sapiens	57-63
21139040-0	2011	The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux.	Quercetin	78-87	ATP binding cassette subfamily G member 2	Canis lupus familiaris	63-68
21308698-5	2011	Quercetin downregulates uPA, uPAR and EGF, EGF-R mRNA expressions.	Quercetin	0-9	plasminogen activator, urokinase	Homo sapiens	24-27
21308698-5	2011	Quercetin downregulates uPA, uPAR and EGF, EGF-R mRNA expressions.	Quercetin	0-9	plasminogen activator, urokinase receptor	Homo sapiens	29-33
21308698-5	2011	Quercetin downregulates uPA, uPAR and EGF, EGF-R mRNA expressions.	Quercetin	0-9	epidermal growth factor receptor	Homo sapiens	43-48
21308698-6	2011	Quercetin inhibits cell survival factor beta-catenin, NF-kappaB and also proliferative signalling molecules such as p-EGF-R, N-Ras, Raf-1, c.Fos c.Jun and p-c.Jun protein expressions.	Quercetin	0-9	catenin beta 1	Homo sapiens	40-52
21308698-6	2011	Quercetin inhibits cell survival factor beta-catenin, NF-kappaB and also proliferative signalling molecules such as p-EGF-R, N-Ras, Raf-1, c.Fos c.Jun and p-c.Jun protein expressions.	Quercetin	0-9	epidermal growth factor receptor	Homo sapiens	118-123
21308698-6	2011	Quercetin inhibits cell survival factor beta-catenin, NF-kappaB and also proliferative signalling molecules such as p-EGF-R, N-Ras, Raf-1, c.Fos c.Jun and p-c.Jun protein expressions.	Quercetin	0-9	NRAS proto-oncogene, GTPase	Homo sapiens	125-130
21308698-6	2011	Quercetin inhibits cell survival factor beta-catenin, NF-kappaB and also proliferative signalling molecules such as p-EGF-R, N-Ras, Raf-1, c.Fos c.Jun and p-c.Jun protein expressions.	Quercetin	0-9	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	132-140
21308698-7	2011	But quercetin increased p38 mitogen-activated protein kinase protein expression.	Quercetin	4-13	mitogen-activated protein kinase 14	Homo sapiens	24-27
21139040-11	2011	We report for the first time that kaempferol is a Bcrp substrate, and our results indicate that kaempferol inhibits Bcrp-mediated quercetin efflux.	Quercetin	130-139	ATP binding cassette subfamily G member 2	Canis lupus familiaris	116-120
21139040-2	2011	The ATP-binding cassette efflux transporter, breast cancer resistance protein (Bcrp, Abcg2), is involved in the transport of quercetin and represents a possible mechanism for the low bioavailability of quercetin.	Quercetin	125-134	ATP binding cassette subfamily G member 2	Canis lupus familiaris	45-77
21139040-2	2011	The ATP-binding cassette efflux transporter, breast cancer resistance protein (Bcrp, Abcg2), is involved in the transport of quercetin and represents a possible mechanism for the low bioavailability of quercetin.	Quercetin	125-134	ATP binding cassette subfamily G member 2	Canis lupus familiaris	79-83
21139040-2	2011	The ATP-binding cassette efflux transporter, breast cancer resistance protein (Bcrp, Abcg2), is involved in the transport of quercetin and represents a possible mechanism for the low bioavailability of quercetin.	Quercetin	125-134	ATP binding cassette subfamily G member 2	Canis lupus familiaris	85-90
21139040-2	2011	The ATP-binding cassette efflux transporter, breast cancer resistance protein (Bcrp, Abcg2), is involved in the transport of quercetin and represents a possible mechanism for the low bioavailability of quercetin.	Quercetin	202-211	ATP binding cassette subfamily G member 2	Canis lupus familiaris	45-77
21139040-2	2011	The ATP-binding cassette efflux transporter, breast cancer resistance protein (Bcrp, Abcg2), is involved in the transport of quercetin and represents a possible mechanism for the low bioavailability of quercetin.	Quercetin	202-211	ATP binding cassette subfamily G member 2	Canis lupus familiaris	79-83
21139040-2	2011	The ATP-binding cassette efflux transporter, breast cancer resistance protein (Bcrp, Abcg2), is involved in the transport of quercetin and represents a possible mechanism for the low bioavailability of quercetin.	Quercetin	202-211	ATP binding cassette subfamily G member 2	Canis lupus familiaris	85-90
21139040-3	2011	Our objective was to investigate whether kaempferol inhibits Bcrp-mediated quercetin efflux and determine whether it is a substrate for BCRP.	Quercetin	75-84	ATP binding cassette subfamily G member 2	Canis lupus familiaris	61-65
20828867-0	2011	Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-kappaB signaling pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	99-108
20828867-4	2011	The present study was designed to examine the involvement of TLR2 and TLR4 in the oxidized LDL induced inflammation in human PBMCs and the effect of flavonoid quercetin on TLR-NF-kappaB signaling mechanism.	Quercetin	159-168	nuclear factor kappa B subunit 1	Homo sapiens	176-185
20828867-6	2011	50 mug/ml ox-LDL treatment significantly up regulated TLR2 and TLR4 expression in isol human PBMCs after 24 h of culture and this was down regulated by quercetin at 25 muM concentration.	Quercetin	152-161	toll like receptor 2	Homo sapiens	54-58
20828867-6	2011	50 mug/ml ox-LDL treatment significantly up regulated TLR2 and TLR4 expression in isol human PBMCs after 24 h of culture and this was down regulated by quercetin at 25 muM concentration.	Quercetin	152-161	toll like receptor 4	Homo sapiens	63-67
20828867-8	2011	Supplementation of quercetin significantly modulates the NF-kappaB p65 nuclear translocation.	Quercetin	19-28	nuclear factor kappa B subunit 1	Homo sapiens	57-66
20828867-8	2011	Supplementation of quercetin significantly modulates the NF-kappaB p65 nuclear translocation.	Quercetin	19-28	RELA proto-oncogene, NF-kB subunit	Homo sapiens	67-70
20828867-9	2011	The cytokine IL-6 production was significantly increased in ox-LDL treated group and was decreased by quercetin treatment.	Quercetin	102-111	interleukin 6	Homo sapiens	13-17
20828867-10	2011	Quercetin mediated reduction of TLR2 and TLR4 expression and the inhibition of nuclear translocation of NF-kappaB p65 in turn decreased the inflammatory enzymes like 5-LOX and COX and also decreased the mRNA expression of inducible enzymes like COX-2 and iNOS.	Quercetin	0-9	toll like receptor 2	Homo sapiens	32-36
20828867-10	2011	Quercetin mediated reduction of TLR2 and TLR4 expression and the inhibition of nuclear translocation of NF-kappaB p65 in turn decreased the inflammatory enzymes like 5-LOX and COX and also decreased the mRNA expression of inducible enzymes like COX-2 and iNOS.	Quercetin	0-9	toll like receptor 4	Homo sapiens	41-45
20828867-10	2011	Quercetin mediated reduction of TLR2 and TLR4 expression and the inhibition of nuclear translocation of NF-kappaB p65 in turn decreased the inflammatory enzymes like 5-LOX and COX and also decreased the mRNA expression of inducible enzymes like COX-2 and iNOS.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	104-113
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	284-288
20828867-10	2011	Quercetin mediated reduction of TLR2 and TLR4 expression and the inhibition of nuclear translocation of NF-kappaB p65 in turn decreased the inflammatory enzymes like 5-LOX and COX and also decreased the mRNA expression of inducible enzymes like COX-2 and iNOS.	Quercetin	0-9	RELA proto-oncogene, NF-kB subunit	Homo sapiens	114-117
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	aurora kinase A	Homo sapiens	290-306
20828867-10	2011	Quercetin mediated reduction of TLR2 and TLR4 expression and the inhibition of nuclear translocation of NF-kappaB p65 in turn decreased the inflammatory enzymes like 5-LOX and COX and also decreased the mRNA expression of inducible enzymes like COX-2 and iNOS.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	CDC like kinase 1	Homo sapiens	308-312
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	fms related receptor tyrosine kinase 3	Homo sapiens	314-318
20828867-10	2011	Quercetin mediated reduction of TLR2 and TLR4 expression and the inhibition of nuclear translocation of NF-kappaB p65 in turn decreased the inflammatory enzymes like 5-LOX and COX and also decreased the mRNA expression of inducible enzymes like COX-2 and iNOS.	Quercetin	0-9	nitric oxide synthase 2	Homo sapiens	255-259
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	Janus kinase 3	Homo sapiens	320-324
20828867-11	2011	Quercetin inhibited the ox-LDL induced TLR2 and TLR4 expression at mRNA level and modulated the TLR-NF-kappaB signaling pathway thereby inhibited the cytokine production and down regulated the activity of inflammatory enzymes thus have protective effect against the ox-LDL induced inflammation in PBMCs.	Quercetin	0-9	toll like receptor 2	Homo sapiens	39-43
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	NIMA related kinase 4	Homo sapiens	331-335
20828867-11	2011	Quercetin inhibited the ox-LDL induced TLR2 and TLR4 expression at mRNA level and modulated the TLR-NF-kappaB signaling pathway thereby inhibited the cytokine production and down regulated the activity of inflammatory enzymes thus have protective effect against the ox-LDL induced inflammation in PBMCs.	Quercetin	0-9	toll like receptor 4	Homo sapiens	48-52
20828867-11	2011	Quercetin inhibited the ox-LDL induced TLR2 and TLR4 expression at mRNA level and modulated the TLR-NF-kappaB signaling pathway thereby inhibited the cytokine production and down regulated the activity of inflammatory enzymes thus have protective effect against the ox-LDL induced inflammation in PBMCs.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	100-109
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	NIMA related kinase 9	Homo sapiens	337-341
21054438-7	2011	We suggest that the dark seed coat of Arabidopsis is related to soluble proanthocyanidin content and that quercetin holds the key to the function of TT19.	Quercetin	106-115	glutathione S-transferase phi 12	Arabidopsis thaliana	149-153
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	p21 (RAC1) activated kinase 3	Homo sapiens	343-347
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	349-353
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	ret proto-oncogene	Homo sapiens	355-358
21206969-6	2011	Data from the current study showed that 2 muM quercetin, a low concentration that represents less than 10% of its IC50 growth-inhibitory concentration as calculated from the average of eight distinct cancer cell lines, decreased the activity of 16 kinases by more than 80%, including ABL1, Aurora-A, -B, -C, CLK1, FLT3, JAK3, MET, NEK4, NEK9, PAK3, PIM1, RET, FGF-R2, PDGF-Ralpha and -Rss.	Quercetin	46-55	fibroblast growth factor receptor 2	Homo sapiens	360-366
20579867-2	2011	Quercetin and isorhamnetin but not Q3G significantly decreased mRNA and protein levels of tumor necrosis factor alpha.	Quercetin	0-9	tumor necrosis factor	Mus musculus	90-117
20579867-3	2011	Furthermore a significant decrease in mRNA levels of interleukin 1beta, interleukin 6, macrophage inflammatory protein 1alpha and inducible nitric oxide synthase was evident in response to the quercetin treatment.	Quercetin	193-202	interleukin 1 beta	Mus musculus	53-70
20579867-3	2011	Furthermore a significant decrease in mRNA levels of interleukin 1beta, interleukin 6, macrophage inflammatory protein 1alpha and inducible nitric oxide synthase was evident in response to the quercetin treatment.	Quercetin	193-202	chemokine (C-C motif) ligand 3	Mus musculus	87-161
20579867-5	2011	Anti-inflammatory properties of quercetin and isorhamnetin were accompanied by an increase in heme oxygenase 1 protein levels, a downstream target of the transcription factor Nrf2, known to antagonize chronic inflammation.	Quercetin	32-41	heme oxygenase 1	Mus musculus	94-110
20579867-5	2011	Anti-inflammatory properties of quercetin and isorhamnetin were accompanied by an increase in heme oxygenase 1 protein levels, a downstream target of the transcription factor Nrf2, known to antagonize chronic inflammation.	Quercetin	32-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	175-179
21749381-3	2011	Selection of the optimized SLN formulation, using brute-force methodology and overlay plots, was based on its efficiency of entrapping quercetin inside the lipophilic core, particle size, surface charge potential and ability of the SLNs to release the entrapped drug completely.	Quercetin	135-144	sarcolipin	Rattus norvegicus	27-30
21749381-6	2011	In all the in-vivo behavioral and biochemical experiments, the rats treated with SLN-encapsulated quercetin showed markedly better memory-retention vis-a-vis test and pure quercetin-treated rats.	Quercetin	98-107	sarcolipin	Rattus norvegicus	81-84
21749381-6	2011	In all the in-vivo behavioral and biochemical experiments, the rats treated with SLN-encapsulated quercetin showed markedly better memory-retention vis-a-vis test and pure quercetin-treated rats.	Quercetin	172-181	sarcolipin	Rattus norvegicus	81-84
21282043-0	2011	Quercetin inhibits UV irradiation-induced inflammatory cytokine production in primary human keratinocytes by suppressing NF-kappaB pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	121-130
21282043-6	2011	OBJECTIVE: To elucidate the underlying mechanism, we examined the effect of quercetin on UV irradiation induced activation of NF-kappaB and AP-1 pathways.	Quercetin	76-85	nuclear factor kappa B subunit 1	Homo sapiens	126-135
21282043-6	2011	OBJECTIVE: To elucidate the underlying mechanism, we examined the effect of quercetin on UV irradiation induced activation of NF-kappaB and AP-1 pathways.	Quercetin	76-85	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-144
21282043-8	2011	RESULTS: Quercetin decreased UV irradiation-induced NF-kappaB DNA-binding by 80%.	Quercetin	9-18	nuclear factor kappa B subunit 1	Homo sapiens	52-61
21282043-9	2011	Consequently, quercetin suppressed UV irradiation-induced expression of inflammatory cytokines IL-1beta (~60%), IL-6 (~80%), IL-8 (~76%) and TNF-alpha (~69%).	Quercetin	14-23	interleukin 1 beta	Homo sapiens	95-103
21282043-9	2011	Consequently, quercetin suppressed UV irradiation-induced expression of inflammatory cytokines IL-1beta (~60%), IL-6 (~80%), IL-8 (~76%) and TNF-alpha (~69%).	Quercetin	14-23	interleukin 6	Homo sapiens	112-116
21282043-9	2011	Consequently, quercetin suppressed UV irradiation-induced expression of inflammatory cytokines IL-1beta (~60%), IL-6 (~80%), IL-8 (~76%) and TNF-alpha (~69%).	Quercetin	14-23	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
21282043-9	2011	Consequently, quercetin suppressed UV irradiation-induced expression of inflammatory cytokines IL-1beta (~60%), IL-6 (~80%), IL-8 (~76%) and TNF-alpha (~69%).	Quercetin	14-23	tumor necrosis factor	Homo sapiens	141-150
21282043-12	2011	CONCLUSION: Our data indicate that the ability of quercetin to block UV irradiation-induced skin inflammation is mediated, at least in part, by its inhibitory effect on NF-kappaB activation and inflammatory cytokine production.	Quercetin	50-59	nuclear factor kappa B subunit 1	Homo sapiens	169-178
21177254-5	2011	In vitro exposure to genistein/quercetin induced higher numbers of Mll rearrangements in bone marrow cells of Atm-DeltaSRI mutant mice compared with wt mice.	Quercetin	31-40	lysine (K)-specific methyltransferase 2A	Mus musculus	67-70
21177254-5	2011	In vitro exposure to genistein/quercetin induced higher numbers of Mll rearrangements in bone marrow cells of Atm-DeltaSRI mutant mice compared with wt mice.	Quercetin	31-40	ataxia telangiectasia mutated	Mus musculus	110-113
21177254-8	2011	These data suggest that prenatal exposure to both genistein and quercetin supplements could increase the risk on Mll rearrangements especially in the presence of compromised DNA repair.	Quercetin	64-73	lysine (K)-specific methyltransferase 2A	Mus musculus	113-116
21235242-9	2011	Furthermore, the in vitro and in vivo effects of the active constituents of NNE, quercetin, and catechin, on glucose-induced insulin secretion and blood glucose regulation were evaluated.	Quercetin	81-90	insulin	Homo sapiens	125-132
21275387-0	2011	Quercetin reduces neutrophil recruitment induced by CXCL8, LTB4, and fMLP: inhibition of actin polymerization.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	52-57
21275387-0	2011	Quercetin reduces neutrophil recruitment induced by CXCL8, LTB4, and fMLP: inhibition of actin polymerization.	Quercetin	0-9	formyl peptide receptor 1	Homo sapiens	69-73
21167840-4	2011	MAIN METHODS: Paeoniflorin and quercetin were intraperitoneally administered in mouse and Hsp70 and other proteins in mouse tissues were detected by western blotting.	Quercetin	31-40	heat shock protein 1B	Mus musculus	90-95
21051700-0	2011	Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway.	Quercetin	0-9	peroxiredoxin 3	Homo sapiens	36-58
21051700-0	2011	Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway.	Quercetin	0-9	GA binding protein transcription factor subunit alpha	Homo sapiens	67-71
21051700-0	2011	Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway.	Quercetin	0-9	nuclear respiratory factor 1	Homo sapiens	72-76
21051700-6	2011	RESULTS: Expression of the PRDX3 and PRDX5 genes was induced by quercetin in a time- and dose-dependent manner.	Quercetin	64-73	peroxiredoxin 3	Homo sapiens	27-32
21051700-6	2011	RESULTS: Expression of the PRDX3 and PRDX5 genes was induced by quercetin in a time- and dose-dependent manner.	Quercetin	64-73	peroxiredoxin 5	Homo sapiens	37-42
21051700-8	2011	Quercetin can also induce the expression of Nrf2 and NRF1 but not of Ets1, Ets2, or Foxo3a.	Quercetin	0-9	GA binding protein transcription factor subunit alpha	Homo sapiens	44-48
21051700-8	2011	Quercetin can also induce the expression of Nrf2 and NRF1 but not of Ets1, Ets2, or Foxo3a.	Quercetin	0-9	nuclear respiratory factor 1	Homo sapiens	53-57
21051700-12	2011	Finally, NRF1 activation by quercetin was completely abolished by the knockdown of Nrf2.	Quercetin	28-37	nuclear respiratory factor 1	Homo sapiens	9-13
21051700-12	2011	Finally, NRF1 activation by quercetin was completely abolished by the knockdown of Nrf2.	Quercetin	28-37	GA binding protein transcription factor subunit alpha	Homo sapiens	83-87
21051700-13	2011	CONCLUSIONS: Quercetin upregulates the antioxidant peroxiredoxins through the activation of the Nrf2/NRF1 transcription pathway and protects against oxidative stress-induced ocular disease.	Quercetin	13-22	GA binding protein transcription factor subunit alpha	Homo sapiens	96-100
21051700-13	2011	CONCLUSIONS: Quercetin upregulates the antioxidant peroxiredoxins through the activation of the Nrf2/NRF1 transcription pathway and protects against oxidative stress-induced ocular disease.	Quercetin	13-22	nuclear respiratory factor 1	Homo sapiens	101-105
21167840-6	2011	When quercetin was injected before paeoniflorin administration, the induction of Hsp70 was suppressed and the protective effect of paeoniflorin was also diminished.	Quercetin	5-14	heat shock protein 1B	Mus musculus	81-86
20950682-3	2011	At 10 and 100 muM, quercetin had higher metal-chelating activity than rutin carrying rutinose at position C-3 and was also more efficient than rutin in reducing intracellular oxidative stress caused by peroxyl radicals and Cu(2+).	Quercetin	19-28	latexin	Homo sapiens	14-17
21132259-0	2011	Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish.	Quercetin	0-9	nitric oxide synthase 2	Rattus norvegicus	68-72
21132259-8	2011	A mechanistic study showed that quercetin could inhibit NO over-production and iNOS over-expression in PC12 cells and could down-regulate the over-expression of pro-inflammatory genes (e.g. IL-1ss, TNF-alpha and COX-2) in zebrafish, suggesting that these genes play a role in the neuroprotective effect of quercetin.	Quercetin	32-41	nitric oxide synthase 2	Rattus norvegicus	79-83
21132259-8	2011	A mechanistic study showed that quercetin could inhibit NO over-production and iNOS over-expression in PC12 cells and could down-regulate the over-expression of pro-inflammatory genes (e.g. IL-1ss, TNF-alpha and COX-2) in zebrafish, suggesting that these genes play a role in the neuroprotective effect of quercetin.	Quercetin	32-41	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	198-207
21132259-8	2011	A mechanistic study showed that quercetin could inhibit NO over-production and iNOS over-expression in PC12 cells and could down-regulate the over-expression of pro-inflammatory genes (e.g. IL-1ss, TNF-alpha and COX-2) in zebrafish, suggesting that these genes play a role in the neuroprotective effect of quercetin.	Quercetin	32-41	cytochrome c oxidase II, mitochondrial	Danio rerio	212-217
21114495-7	2011	Inhibition of either HSF-1 binding with quercetin or heat shock protein synthesis with KNK437 compromised chemokine induction without compromising cell survival.	Quercetin	40-49	heat shock factor 1	Mus musculus	21-26
21425674-1	2011	Quercetin, kaempferol and to a lesser extent rutin have been reported to have antidiabetic activities when assessed by various assay models including in vitro alpha-glucosidase inhibition studies.	Quercetin	0-9	sucrase-isomaltase	Homo sapiens	159-176
20950682-4	2011	The protective activities of 10 and 100 muM quercetin against Cu(2+)-induced intracellular oxidation were 13.8% and 44.8%, respectively.	Quercetin	44-53	latexin	Homo sapiens	40-43
21075839-3	2011	We recently identified quercetin, a naturally occurring flavonoid, as a probe-dependent, pathway-selective allosteric modulator of GLP-1R-mediated signaling.	Quercetin	23-32	glucagon like peptide 1 receptor	Homo sapiens	131-137
21165570-0	2011	Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells.	Quercetin	0-9	Fas ligand	Homo sapiens	18-22
21165570-4	2011	In the present study, by evaluation of fragmentation of DNA, poly (ADP-ribose) polymerase (PARP) and procaspases, we found that quercetin was able to induce apoptosis of human leukemia HL-60 cells in a dose-dependent manner.	Quercetin	128-137	poly(ADP-ribose) polymerase 1	Homo sapiens	61-89
21165570-4	2011	In the present study, by evaluation of fragmentation of DNA, poly (ADP-ribose) polymerase (PARP) and procaspases, we found that quercetin was able to induce apoptosis of human leukemia HL-60 cells in a dose-dependent manner.	Quercetin	128-137	poly(ADP-ribose) polymerase 1	Homo sapiens	91-95
20971552-6	2011	We show that Wnt inhibitors curcumin and quercetin target downstream beta-catenin activity and effectively repress HBx-mediated regulation of c-MYC and E-cadherin.	Quercetin	41-50	catenin beta 1	Homo sapiens	69-81
21165570-5	2011	Quercetin triggered the extrinsic apoptosis pathway through activation of caspase-8 and induction of Bid cleavage, Bax conformation change and cytochrome c release.	Quercetin	0-9	caspase 8	Homo sapiens	74-83
21165570-5	2011	Quercetin triggered the extrinsic apoptosis pathway through activation of caspase-8 and induction of Bid cleavage, Bax conformation change and cytochrome c release.	Quercetin	0-9	BH3 interacting domain death agonist	Homo sapiens	101-104
21165570-5	2011	Quercetin triggered the extrinsic apoptosis pathway through activation of caspase-8 and induction of Bid cleavage, Bax conformation change and cytochrome c release.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	115-118
21165570-5	2011	Quercetin triggered the extrinsic apoptosis pathway through activation of caspase-8 and induction of Bid cleavage, Bax conformation change and cytochrome c release.	Quercetin	0-9	cytochrome c, somatic	Homo sapiens	143-155
21165570-6	2011	Furthermore, quercetin induced Fas ligand (FasL) expression involving activation of the extracellular signal-regulated kinase (ERK) and Jun N-terminus kinase (JNK) signaling pathways.	Quercetin	13-22	Fas ligand	Homo sapiens	31-41
21165570-6	2011	Furthermore, quercetin induced Fas ligand (FasL) expression involving activation of the extracellular signal-regulated kinase (ERK) and Jun N-terminus kinase (JNK) signaling pathways.	Quercetin	13-22	Fas ligand	Homo sapiens	43-47
21165570-6	2011	Furthermore, quercetin induced Fas ligand (FasL) expression involving activation of the extracellular signal-regulated kinase (ERK) and Jun N-terminus kinase (JNK) signaling pathways.	Quercetin	13-22	mitogen-activated protein kinase 1	Homo sapiens	88-125
21165570-6	2011	Furthermore, quercetin induced Fas ligand (FasL) expression involving activation of the extracellular signal-regulated kinase (ERK) and Jun N-terminus kinase (JNK) signaling pathways.	Quercetin	13-22	mitogen-activated protein kinase 1	Homo sapiens	127-130
21165570-6	2011	Furthermore, quercetin induced Fas ligand (FasL) expression involving activation of the extracellular signal-regulated kinase (ERK) and Jun N-terminus kinase (JNK) signaling pathways.	Quercetin	13-22	mitogen-activated protein kinase 8	Homo sapiens	136-157
21165570-6	2011	Furthermore, quercetin induced Fas ligand (FasL) expression involving activation of the extracellular signal-regulated kinase (ERK) and Jun N-terminus kinase (JNK) signaling pathways.	Quercetin	13-22	mitogen-activated protein kinase 8	Homo sapiens	159-162
21165570-7	2011	In addition to activation of c-Jun, quercetin increased histone H3 acetylation which resulted in the promotion of the expression of FasL.	Quercetin	36-45	Fas ligand	Homo sapiens	132-136
21165570-10	2011	These results demonstrated that quercetin induced FasL-related apoptosis by transactivation through activation of c-jun/AP-1 and promotion of histone H3 acetylation in HL-60 cells.	Quercetin	32-41	Fas ligand	Homo sapiens	50-54
21165570-10	2011	These results demonstrated that quercetin induced FasL-related apoptosis by transactivation through activation of c-jun/AP-1 and promotion of histone H3 acetylation in HL-60 cells.	Quercetin	32-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	114-119
20971552-6	2011	We show that Wnt inhibitors curcumin and quercetin target downstream beta-catenin activity and effectively repress HBx-mediated regulation of c-MYC and E-cadherin.	Quercetin	41-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	142-147
20971552-6	2011	We show that Wnt inhibitors curcumin and quercetin target downstream beta-catenin activity and effectively repress HBx-mediated regulation of c-MYC and E-cadherin.	Quercetin	41-50	cadherin 1	Homo sapiens	152-162
21186817-6	2011	Furthermore, p-coumaric acid, quercetin, and resveratrol increased levels (p &lt; 0.05) of secreted adiponectin, superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase (GST) in TNF-alpha-treated 3T3-L1 adipocytes.	Quercetin	30-39	adiponectin, C1Q and collagen domain containing	Homo sapiens	100-111
21186817-4	2011	The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p &lt; 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds.	Quercetin	41-50	tumor necrosis factor	Homo sapiens	111-120
21186817-6	2011	Furthermore, p-coumaric acid, quercetin, and resveratrol increased levels (p &lt; 0.05) of secreted adiponectin, superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase (GST) in TNF-alpha-treated 3T3-L1 adipocytes.	Quercetin	30-39	superoxide dismutase 1	Homo sapiens	113-133
21186817-4	2011	The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p &lt; 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds.	Quercetin	41-50	interleukin 6	Homo sapiens	159-172
21186817-4	2011	The results showed that p-coumaric acid, quercetin, and resveratrol have greater inhibition (p &lt; 0.05) of a TNF-alpha-induced increase in the production of interleukin-6 (IL-6) among 21 tested polyphenolic compounds.	Quercetin	41-50	interleukin 6	Homo sapiens	174-178
21186817-6	2011	Furthermore, p-coumaric acid, quercetin, and resveratrol increased levels (p &lt; 0.05) of secreted adiponectin, superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase (GST) in TNF-alpha-treated 3T3-L1 adipocytes.	Quercetin	30-39	superoxide dismutase 1	Homo sapiens	135-138
21186817-5	2011	p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes.	Quercetin	17-26	tumor necrosis factor	Homo sapiens	72-81
21186817-5	2011	p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes.	Quercetin	17-26	C-C motif chemokine ligand 2	Homo sapiens	111-145
21186817-6	2011	Furthermore, p-coumaric acid, quercetin, and resveratrol increased levels (p &lt; 0.05) of secreted adiponectin, superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase (GST) in TNF-alpha-treated 3T3-L1 adipocytes.	Quercetin	30-39	glutathione S-transferase kappa 1	Homo sapiens	194-219
21186817-5	2011	p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes.	Quercetin	17-26	C-C motif chemokine ligand 2	Homo sapiens	147-152
21186817-6	2011	Furthermore, p-coumaric acid, quercetin, and resveratrol increased levels (p &lt; 0.05) of secreted adiponectin, superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase (GST) in TNF-alpha-treated 3T3-L1 adipocytes.	Quercetin	30-39	glutathione S-transferase kappa 1	Homo sapiens	221-224
21186817-5	2011	p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes.	Quercetin	17-26	serpin family E member 1	Homo sapiens	155-188
21186817-5	2011	p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes.	Quercetin	17-26	serpin family E member 1	Homo sapiens	190-195
21186817-6	2011	Furthermore, p-coumaric acid, quercetin, and resveratrol increased levels (p &lt; 0.05) of secreted adiponectin, superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase (GST) in TNF-alpha-treated 3T3-L1 adipocytes.	Quercetin	30-39	tumor necrosis factor	Homo sapiens	229-238
21173056-0	2011	Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells.	Quercetin	0-9	caspase 3	Homo sapiens	42-51
21173056-0	2011	Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	67-72
21173056-0	2011	Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	77-93
21173056-5	2011	Furthermore, quercetin down-regulated the expression of anti-apoptosis protein Bcl-2 and up-regulated the expression of pro-apoptosis protein Bax.	Quercetin	13-22	BCL2 apoptosis regulator	Homo sapiens	79-84
21173056-5	2011	Furthermore, quercetin down-regulated the expression of anti-apoptosis protein Bcl-2 and up-regulated the expression of pro-apoptosis protein Bax.	Quercetin	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	142-145
21173056-6	2011	Caspase-3 was also activated by quercetin, which started a caspase-3-depended mitochodrial pathway to induce apoptosis.	Quercetin	32-41	caspase 3	Homo sapiens	0-9
21173056-6	2011	Caspase-3 was also activated by quercetin, which started a caspase-3-depended mitochodrial pathway to induce apoptosis.	Quercetin	32-41	caspase 3	Homo sapiens	59-68
21173056-7	2011	It was also found that quercetin inhibited the expression of the cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein.	Quercetin	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
21173056-7	2011	It was also found that quercetin inhibited the expression of the cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein.	Quercetin	23-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
21445799-4	2011	The effect of quercetin on production of reactive oxygen species (ROS) and nitric oxide (NO) in LPS-stimulated human THP-1 acute monocytic leukemia cells was determined by flow cytometry using CM-H2DCFDA dye.	Quercetin	14-23	GLI family zinc finger 2	Homo sapiens	117-122
21173056-8	2011	Taken together, these findings suggested that quercetin induces apoptosis in a caspase-3-dependent pathway by inhibiting Cox-2 expression and regulates the expression of downstream apoptotic components, including Bcl-2 and Bax.	Quercetin	46-55	caspase 3	Homo sapiens	79-88
21173056-8	2011	Taken together, these findings suggested that quercetin induces apoptosis in a caspase-3-dependent pathway by inhibiting Cox-2 expression and regulates the expression of downstream apoptotic components, including Bcl-2 and Bax.	Quercetin	46-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
21173056-8	2011	Taken together, these findings suggested that quercetin induces apoptosis in a caspase-3-dependent pathway by inhibiting Cox-2 expression and regulates the expression of downstream apoptotic components, including Bcl-2 and Bax.	Quercetin	46-55	BCL2 apoptosis regulator	Homo sapiens	213-218
21173056-8	2011	Taken together, these findings suggested that quercetin induces apoptosis in a caspase-3-dependent pathway by inhibiting Cox-2 expression and regulates the expression of downstream apoptotic components, including Bcl-2 and Bax.	Quercetin	46-55	BCL2 associated X, apoptosis regulator	Homo sapiens	223-226
22393949-7	2011	Furthermore, we demonstrate that quercetin promotes apoptosis of cancer cells by down-regulating the levels of Hsp90 and Hsp70.	Quercetin	33-42	heat shock protein, 3	Mus musculus	111-116
22393949-7	2011	Furthermore, we demonstrate that quercetin promotes apoptosis of cancer cells by down-regulating the levels of Hsp90 and Hsp70.	Quercetin	33-42	heat shock protein 1B	Mus musculus	121-126
22393949-8	2011	Depletion of these two chaperones by quercetin might result in triggering of caspase-3 in treated tumours.	Quercetin	37-46	caspase 3	Mus musculus	77-86
20981318-6	2011	The mean value of IFN-gamma/IL-4 in LPS-treated mice was 0.310 +- 0.066, higher than that of Quercetin and Bornyl Acetate group.	Quercetin	93-102	interferon gamma	Mus musculus	18-27
21949907-9	2011	Visfatin secretion was inhibited by quercetin 10 muM by 16% and 24% at 24 and 48 hours respectively.	Quercetin	36-45	nicotinamide phosphoribosyltransferase	Homo sapiens	0-8
21949907-9	2011	Visfatin secretion was inhibited by quercetin 10 muM by 16% and 24% at 24 and 48 hours respectively.	Quercetin	36-45	latexin	Homo sapiens	49-52
21949907-10	2011	The corresponding changes for quercetin 25 muM were 47% and 48%.	Quercetin	30-39	latexin	Homo sapiens	43-46
21949907-15	2011	Quercetin and resveratrol significantly decreased visfatin secretion from SGBS adipocytes.	Quercetin	0-9	nicotinamide phosphoribosyltransferase	Homo sapiens	50-58
20883830-6	2011	For the St. John"s Wort extract and its single constituents hypericin, pseudohypericin, and quercetin, inhibition exhibited a remarkable dependency on the CYP1A1 genotype.	Quercetin	92-101	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	155-161
21865857-0	2011	Quercetin stimulates NGF-induced neurite outgrowth in PC12 cells via activation of Na(+)/K(+)/2Cl(-) cotransporter.	Quercetin	0-9	nerve growth factor	Rattus norvegicus	21-24
21865857-3	2011	In the present report, we investigated the effect of quercetin, a flavonoid, on NGF-induced neurite outgrowth in PC12 cells (the parental strain of PC12D cells).	Quercetin	53-62	nerve growth factor	Rattus norvegicus	80-83
21865857-4	2011	Quercetin stimulated the NGF-induced neurite outgrowth in a dose-dependent manner.	Quercetin	0-9	nerve growth factor	Rattus norvegicus	25-28
21865857-6	2011	Quercetin stimulated NKCC1 activity (measured as bumetanide-sensitive (86)Rb influx) without any increase in the expression level of NKCC1 protein.	Quercetin	0-9	solute carrier family 12 member 2	Rattus norvegicus	21-26
21865857-8	2011	These observations indicate that quercetin stimulates the NGF-induced neurite outgrowth via an increase in Cl(-) incorporation into the intracellular space by activating NKCC1 in PC12 cell.	Quercetin	33-42	nerve growth factor	Rattus norvegicus	58-61
21865857-8	2011	These observations indicate that quercetin stimulates the NGF-induced neurite outgrowth via an increase in Cl(-) incorporation into the intracellular space by activating NKCC1 in PC12 cell.	Quercetin	33-42	solute carrier family 12 member 2	Rattus norvegicus	170-175
22145036-8	2011	The FLS silenced lines were observed for 20-80% reduction in FLS encoding gene expression and 25-93% reduction in flavonol (quercetin) content.	Quercetin	124-133	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	4-7
21204621-2	2011	Quercetin and KNK437, Hsp70 inhibitors, play an important role in blocking thermotolerance in some cancer cells.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	22-27
21204621-9	2011	In our study, KNK437 and quercetin inhibited thermotolerance in a dose-dependent manner in PC-3 cells.	Quercetin	25-34	chromobox 8	Homo sapiens	91-95
21204621-10	2011	KNK437 and quercetin decreased heat-induced accumulation of Hsp70 mRNA and protein in PC-3 and LNCaP cells.	Quercetin	11-20	heat shock protein family A (Hsp70) member 4	Homo sapiens	60-65
21204621-10	2011	KNK437 and quercetin decreased heat-induced accumulation of Hsp70 mRNA and protein in PC-3 and LNCaP cells.	Quercetin	11-20	chromobox 8	Homo sapiens	86-90
21846189-0	2011	Radiofrequency ablation combined with liposomal quercetin to increase tumour destruction by modulation of heat shock protein production in a small animal model.	Quercetin	48-57	selenoprotein K	Rattus norvegicus	106-124
21846189-9	2011	Combination quercetin-RF decreased Hsp70 expression compared with RF alone at both 4 h (percentage of stained cells/hpf 22.4+-13.9% vs. 38.8+-16.1%, P&lt;0.03) and 24 h (45.2+-10.5% vs. 81.1+-3.6%, P&lt;0.001).	Quercetin	12-21	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	35-40
21846189-11	2011	CONCLUSIONS: Suppression of HSP production using adjuvant liposomal quercetin can increase apoptosis and improve RF ablation-induced tumour destruction.	Quercetin	68-77	selenoprotein K	Rattus norvegicus	28-31
21207318-2	2011	Acutely, uptake of (14)C-BT (10 muM) was decreased by resveratrol, quercetin, myricetin, and chrysin, and increased by xanthohumol, catechin, and epicatechin; and uptake of (14)C-BT (20 mM) was reduced by resveratrol, quercetin, myricetin, chrysin, EGCG, and epicatechin.	Quercetin	67-76	latexin	Homo sapiens	32-35
21207318-2	2011	Acutely, uptake of (14)C-BT (10 muM) was decreased by resveratrol, quercetin, myricetin, and chrysin, and increased by xanthohumol, catechin, and epicatechin; and uptake of (14)C-BT (20 mM) was reduced by resveratrol, quercetin, myricetin, chrysin, EGCG, and epicatechin.	Quercetin	218-227	latexin	Homo sapiens	32-35
21207318-4	2011	Chronically, quercetin and EGCG increased uptake of (14)C-BT (10 muM), whereas myricetin, rutin, chrysin, and xanthohumol decreased it.	Quercetin	13-22	latexin	Homo sapiens	65-68
21207318-5	2011	Moreover, catechin (1 muM), quercetin, myricetin, rutin, EGCG, and chrysin increased uptake of (14)C-BT (20 mM), whereas catechin (0.1 muM) decreased it.	Quercetin	28-37	latexin	Homo sapiens	135-138
21602595-6	2011	Co-administration of Temodal (100 muM) with a low quercetin concentration (5 muM) resulted in a very significant induction of autophagy; however, after treatment with quercetin at a higher concentration (30 muM), apoptosis became the primary mechanism of cell death.	Quercetin	50-59	latexin	Homo sapiens	77-80
21602595-6	2011	Co-administration of Temodal (100 muM) with a low quercetin concentration (5 muM) resulted in a very significant induction of autophagy; however, after treatment with quercetin at a higher concentration (30 muM), apoptosis became the primary mechanism of cell death.	Quercetin	50-59	latexin	Homo sapiens	77-80
22039452-0	2011	Quercetin inhibits IL-1beta-induced inflammation, hyaluronan production and adipogenesis in orbital fibroblasts from Graves" orbitopathy.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	19-27
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	35-68
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	70-76
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	interleukin 6	Homo sapiens	79-98
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-133
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	165-173
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	195-201
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	interleukin 6	Homo sapiens	203-207
22039452-3	2011	Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1beta-induced increases in ICAM-1, IL-6, and IL-8 mRNA.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	213-217
22039452-4	2011	Increased hyaluronan production induced by IL-1beta or tumor necrosis factor-alpha was suppressed by quercetin in a dose- and time-dependent manner.	Quercetin	101-110	interleukin 1 beta	Homo sapiens	43-82
22039452-5	2011	Treatment with noncytotoxic doses of quercetin inhibited accumulation of intracytoplasmic lipid droplets and resulted in a dose-dependent decrease in expression of peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein (C/EBP) alpha, and C/EBPbeta proteins.	Quercetin	37-46	peroxisome proliferator activated receptor gamma	Homo sapiens	164-212
22039452-5	2011	Treatment with noncytotoxic doses of quercetin inhibited accumulation of intracytoplasmic lipid droplets and resulted in a dose-dependent decrease in expression of peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein (C/EBP) alpha, and C/EBPbeta proteins.	Quercetin	37-46	CCAAT enhancer binding protein alpha	Homo sapiens	246-258
22039452-5	2011	Treatment with noncytotoxic doses of quercetin inhibited accumulation of intracytoplasmic lipid droplets and resulted in a dose-dependent decrease in expression of peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein (C/EBP) alpha, and C/EBPbeta proteins.	Quercetin	37-46	CCAAT enhancer binding protein beta	Homo sapiens	264-273
21857970-0	2011	Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	21-37
21857970-0	2011	Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling.	Quercetin	0-9	E1A binding protein p300	Homo sapiens	90-94
21857970-8	2011	Treatment of cells with p300 HAT inhibitor roscovitine was as effective as quercetin at inhibiting p300 HAT activity.	Quercetin	75-84	E1A binding protein p300	Homo sapiens	99-107
21857970-3	2011	Here, we reported the regulatory actions of quercetin on cyclooxygenase-2 (COX-2), an important mediator in inflammation and tumor promotion, and revealed the underlying mechanisms.	Quercetin	44-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	57-73
21857970-10	2011	Conversely, gene delivery of constitutively active p300 significantly reversed the quercetin-mediated inhibition of endogenous HAT activity.	Quercetin	83-92	E1A binding protein p300	Homo sapiens	51-55
21857970-3	2011	Here, we reported the regulatory actions of quercetin on cyclooxygenase-2 (COX-2), an important mediator in inflammation and tumor promotion, and revealed the underlying mechanisms.	Quercetin	44-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	75-80
21857970-11	2011	These results indicate that quercetin suppresses COX-2 expression by inhibiting the p300 signaling and blocking the binding of multiple transactivators to COX-2 promoter.	Quercetin	28-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	49-54
21857970-4	2011	Quercetin significantly suppressed COX-2 mRNA and protein expression and prostaglandin (PG) E(2) production, as well as COX-2 promoter activation in breast cancer cells.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	35-40
21857970-11	2011	These results indicate that quercetin suppresses COX-2 expression by inhibiting the p300 signaling and blocking the binding of multiple transactivators to COX-2 promoter.	Quercetin	28-37	E1A binding protein p300	Homo sapiens	84-88
21857970-11	2011	These results indicate that quercetin suppresses COX-2 expression by inhibiting the p300 signaling and blocking the binding of multiple transactivators to COX-2 promoter.	Quercetin	28-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	155-160
21857970-5	2011	Quercetin also significantly inhibited COX-2-mediated angiogenesis in human endothelial cells in a dose-dependent manner.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	39-44
21857970-12	2011	Our findings therefore reveal a novel mechanism of action of quercetin and suggest a potential use for quercetin in the treatment of COX-2-mediated diseases such as breast cancers.	Quercetin	61-70	prostaglandin-endoperoxide synthase 2	Homo sapiens	133-138
21857970-12	2011	Our findings therefore reveal a novel mechanism of action of quercetin and suggest a potential use for quercetin in the treatment of COX-2-mediated diseases such as breast cancers.	Quercetin	103-112	prostaglandin-endoperoxide synthase 2	Homo sapiens	133-138
21857970-6	2011	The in vitro streptavidin-agarose pulldown assay and in vivo chromatin immunoprecipitation assay showed that quercetin considerably inhibited the binding of the transactivators CREB2, C-Jun, C/EBPbeta and NF-kappaB and blocked the recruitment of the coactivator p300 to COX-2 promoter.	Quercetin	109-118	activating transcription factor 2	Homo sapiens	177-182
21857970-6	2011	The in vitro streptavidin-agarose pulldown assay and in vivo chromatin immunoprecipitation assay showed that quercetin considerably inhibited the binding of the transactivators CREB2, C-Jun, C/EBPbeta and NF-kappaB and blocked the recruitment of the coactivator p300 to COX-2 promoter.	Quercetin	109-118	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	184-189
21857970-6	2011	The in vitro streptavidin-agarose pulldown assay and in vivo chromatin immunoprecipitation assay showed that quercetin considerably inhibited the binding of the transactivators CREB2, C-Jun, C/EBPbeta and NF-kappaB and blocked the recruitment of the coactivator p300 to COX-2 promoter.	Quercetin	109-118	CCAAT enhancer binding protein beta	Homo sapiens	191-200
21857970-6	2011	The in vitro streptavidin-agarose pulldown assay and in vivo chromatin immunoprecipitation assay showed that quercetin considerably inhibited the binding of the transactivators CREB2, C-Jun, C/EBPbeta and NF-kappaB and blocked the recruitment of the coactivator p300 to COX-2 promoter.	Quercetin	109-118	E1A binding protein p300	Homo sapiens	262-266
21857970-6	2011	The in vitro streptavidin-agarose pulldown assay and in vivo chromatin immunoprecipitation assay showed that quercetin considerably inhibited the binding of the transactivators CREB2, C-Jun, C/EBPbeta and NF-kappaB and blocked the recruitment of the coactivator p300 to COX-2 promoter.	Quercetin	109-118	prostaglandin-endoperoxide synthase 2	Homo sapiens	270-275
21857970-7	2011	Moreover, quercetin effectively inhibited p300 histone acetyltransferase (HAT) activity, thereby attenuating the p300-mediated acetylation of NF-kappaB.	Quercetin	10-19	E1A binding protein p300	Homo sapiens	42-46
21857970-7	2011	Moreover, quercetin effectively inhibited p300 histone acetyltransferase (HAT) activity, thereby attenuating the p300-mediated acetylation of NF-kappaB.	Quercetin	10-19	E1A binding protein p300	Homo sapiens	113-117
22203790-0	2011	Quercetin protects primary human osteoblasts exposed to cigarette smoke through activation of the antioxidative enzymes HO-1 and SOD-1.	Quercetin	0-9	heme oxygenase 1	Homo sapiens	120-124
21253976-8	2011	Quercetin, a natural polyphenolic flavonoid that has been widely investigated for its other health benefits, may act as an inducer of SirT1.	Quercetin	0-9	sirtuin 1	Homo sapiens	134-139
22203790-0	2011	Quercetin protects primary human osteoblasts exposed to cigarette smoke through activation of the antioxidative enzymes HO-1 and SOD-1.	Quercetin	0-9	superoxide dismutase 1	Homo sapiens	129-134
22203790-6	2011	Quercetin increased the expression of the anti-oxidative enzymes heme-oxygenase- (HO-) 1 and superoxide-dismutase- (SOD-) 1.	Quercetin	0-9	heme oxygenase 1	Homo sapiens	65-88
22203790-6	2011	Quercetin increased the expression of the anti-oxidative enzymes heme-oxygenase- (HO-) 1 and superoxide-dismutase- (SOD-) 1.	Quercetin	0-9	superoxide dismutase 1	Homo sapiens	93-123
22203790-7	2011	Inhibiting HO-1 activity abolished the protective effect of Quercetin.	Quercetin	60-69	heme oxygenase 1	Homo sapiens	11-15
22203790-9	2011	Quercetin can diminish this damage by scavenging the radicals and by upregulating the expression of HO-1 and SOD-1.	Quercetin	0-9	heme oxygenase 1	Homo sapiens	100-104
22203790-9	2011	Quercetin can diminish this damage by scavenging the radicals and by upregulating the expression of HO-1 and SOD-1.	Quercetin	0-9	superoxide dismutase 1	Homo sapiens	109-114
20858478-0	2010	The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-kappaB inhibition.	Quercetin	14-23	tumor protein p53	Homo sapiens	132-135
21319366-0	2011	[Determination of quercetin metabolism in UGT1A3 cDNA-expressing cells by RP-HPLC].	Quercetin	18-27	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	42-48
21319366-1	2011	OBJECTIVE: To develop a RP-HPLC method for the determination of quercetin in UGT1A3 cDNA-transfected cells.	Quercetin	64-73	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	77-83
21319366-2	2011	METHODS: The lysate of cells transfected with human recombinant uridine 5-diphosphate glucuronosyltransferases UGT1A3 cDNA was co-incubated with quercetin, the reaction was terminated with acetonitrile, and luteolin was used as internal standard.	Quercetin	145-154	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	111-117
21319366-10	2011	CONCLUSION: The method established is accurate and simple and suitable for the determination of quercetin in UGT1A3 cDNA-expressed cells.	Quercetin	96-105	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	109-115
20858478-0	2010	The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-kappaB inhibition.	Quercetin	14-23	nuclear factor kappa B subunit 1	Homo sapiens	150-159
20858478-4	2010	The results demonstrate that quercetin suppressed the viability of HeLa cells in a dose-dependent manner by inducing G2/M phase cell cycle arrest and mitochondrial apoptosis through a p53-dependent mechanism.	Quercetin	29-38	tumor protein p53	Homo sapiens	184-187
20943792-0	2010	Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	71-99
21150830-4	2010	High performance liquid chromatography (HPLC) and LC/MS analysis showed that the main active compounds in P-60 were phenols, such as caffeic acid, rosmarinic acid, rutin and quercetin.	Quercetin	174-183	plasma protein 1	Mus musculus	106-110
20943792-13	2010	CONCLUSION: These data suggest that quercetin is equally or more effective than trans-RSV in attenuating TNF-alpha-mediated inflammation and insulin resistance in primary human adipocytes.	Quercetin	36-45	tumor necrosis factor	Homo sapiens	105-114
20943792-8	2010	Quercetin attenuated TNF-alpha-mediated phosphorylation of extracellular signal-related kinase and c-Jun-NH2 terminal kinase, whereas trans-RSV attenuated only c-Jun-NH2 terminal kinase phosphorylation.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	21-30
20943792-13	2010	CONCLUSION: These data suggest that quercetin is equally or more effective than trans-RSV in attenuating TNF-alpha-mediated inflammation and insulin resistance in primary human adipocytes.	Quercetin	36-45	insulin	Homo sapiens	141-148
20943792-8	2010	Quercetin attenuated TNF-alpha-mediated phosphorylation of extracellular signal-related kinase and c-Jun-NH2 terminal kinase, whereas trans-RSV attenuated only c-Jun-NH2 terminal kinase phosphorylation.	Quercetin	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-104
20943792-0	2010	Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes.	Quercetin	0-9	insulin	Homo sapiens	127-134
20943792-9	2010	Quercetin and trans-RSV attenuated TNF-alpha-mediated phosphorylation of c-Jun and degradation of inhibitory kappaB protein.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	35-44
20943792-9	2010	Quercetin and trans-RSV attenuated TNF-alpha-mediated phosphorylation of c-Jun and degradation of inhibitory kappaB protein.	Quercetin	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
20943792-1	2010	BACKGROUND: Quercetin and trans-resveratrol (trans-RSV) are plant polyphenols reported to reduce inflammation or insulin resistance associated with obesity.	Quercetin	12-21	insulin	Homo sapiens	113-120
20943792-10	2010	Quercetin, but not trans-RSV, decreased TNF-alpha-induced nuclear factor-kappaB transcriptional activity.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	40-49
20943792-11	2010	Quercetin and trans-RSV attenuated the TNF-alpha-mediated suppression of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgamma target genes and of PPARgamma protein concentrations and transcriptional activity.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	39-48
20943792-11	2010	Quercetin and trans-RSV attenuated the TNF-alpha-mediated suppression of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgamma target genes and of PPARgamma protein concentrations and transcriptional activity.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	73-121
20943792-11	2010	Quercetin and trans-RSV attenuated the TNF-alpha-mediated suppression of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgamma target genes and of PPARgamma protein concentrations and transcriptional activity.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	123-132
20943792-11	2010	Quercetin and trans-RSV attenuated the TNF-alpha-mediated suppression of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgamma target genes and of PPARgamma protein concentrations and transcriptional activity.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	138-147
20943792-11	2010	Quercetin and trans-RSV attenuated the TNF-alpha-mediated suppression of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgamma target genes and of PPARgamma protein concentrations and transcriptional activity.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	138-147
20943792-2	2010	Recently, we showed that grape powder extract, which contains quercetin and trans-RSV, attenuates markers of inflammation in human adipocytes and macrophages and insulin resistance in human adipocytes.	Quercetin	62-71	insulin	Homo sapiens	162-169
20943792-12	2010	Quercetin prevented the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1 and protein tyrosine phosphatase-1B gene expression and the suppression of insulin-stimulated glucose uptake, whereas trans-RSV prevented only the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	24-33
20943792-4	2010	OBJECTIVE: The aim of this study was to examine the extent to which quercetin and trans-RSV prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-alpha (TNF-alpha)-an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals.	Quercetin	68-77	insulin	Homo sapiens	118-125
20943792-12	2010	Quercetin prevented the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1 and protein tyrosine phosphatase-1B gene expression and the suppression of insulin-stimulated glucose uptake, whereas trans-RSV prevented only the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1.	Quercetin	0-9	insulin receptor substrate 1	Homo sapiens	69-97
20943792-4	2010	OBJECTIVE: The aim of this study was to examine the extent to which quercetin and trans-RSV prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-alpha (TNF-alpha)-an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals.	Quercetin	68-77	tumor necrosis factor	Homo sapiens	190-217
20943792-12	2010	Quercetin prevented the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1 and protein tyrosine phosphatase-1B gene expression and the suppression of insulin-stimulated glucose uptake, whereas trans-RSV prevented only the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1.	Quercetin	0-9	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	102-133
20943792-4	2010	OBJECTIVE: The aim of this study was to examine the extent to which quercetin and trans-RSV prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-alpha (TNF-alpha)-an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals.	Quercetin	68-77	tumor necrosis factor	Homo sapiens	219-228
20943792-12	2010	Quercetin prevented the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1 and protein tyrosine phosphatase-1B gene expression and the suppression of insulin-stimulated glucose uptake, whereas trans-RSV prevented only the TNF-alpha-mediated serine phosphorylation of insulin receptor substrate-1.	Quercetin	0-9	insulin	Homo sapiens	69-76
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	tumor necrosis factor	Homo sapiens	69-78
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	interleukin 1 beta	Homo sapiens	148-156
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	C-C motif chemokine ligand 2	Homo sapiens	168-202
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	C-C motif chemokine ligand 2	Homo sapiens	204-209
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	interleukin 6	Homo sapiens	232-236
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
20943792-7	2010	RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.	Quercetin	9-18	C-C motif chemokine ligand 2	Homo sapiens	248-253
21042744-0	2010	Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells.	Quercetin	69-78	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	51-55
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Quercetin	135-144	solute carrier organic anion transporter family member 1A2	Homo sapiens	177-184
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Quercetin	135-144	solute carrier organic anion transporter family member 2B1	Homo sapiens	199-206
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Quercetin	135-144	solute carrier organic anion transporter family member 1A2	Homo sapiens	240-247
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Quercetin	135-144	solute carrier organic anion transporter family member 2B1	Homo sapiens	258-265
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Quercetin	135-144	latexin	Homo sapiens	190-193
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Quercetin	135-144	solute carrier organic anion transporter family member 1A2	Homo sapiens	240-247
20797388-6	2010	K(i) values of all three flavonoids determined from Dixon plot analyses using BSP as substrate indicated a competitive inhibition with quercetin as the most potent inhibitor of OATP1A2 (22.0muM) and OATP2B1 (8.7muM) followed by kaempferol (OATP1A2: 25.2muM, OATP2B1: 15.1muM) and apigenin (OATP1A2: 32.4muM OATP2B1: 20.8muM).	Quercetin	135-144	solute carrier organic anion transporter family member 2B1	Homo sapiens	258-265
20797388-7	2010	Apigenin, kaempferol, and quercetin led to a concentration-dependent decrease of the OATP1A2-mediated fexofenadine transport with IC(50) values of 4.3muM, 12.0muM, and 12.6muM, respectively.	Quercetin	26-35	solute carrier organic anion transporter family member 1A2	Homo sapiens	85-92
20797388-9	2010	These data indicate that modification of OATP1A2 and OATP2B1 transport activity by apigenin, kaempferol, and quercetin may be a mechanism for food-drug or drug-drug interactions in humans.	Quercetin	109-118	solute carrier organic anion transporter family member 1A2	Homo sapiens	41-48
20797388-9	2010	These data indicate that modification of OATP1A2 and OATP2B1 transport activity by apigenin, kaempferol, and quercetin may be a mechanism for food-drug or drug-drug interactions in humans.	Quercetin	109-118	solute carrier organic anion transporter family member 2B1	Homo sapiens	53-60
21138867-13	2010	CONCLUSIONS: These data suggest that quercetin may be useful for the treatment of leukemia by preferentially inducing apoptosis in leukemia versus normal hematopoietic cells through a process involving Mcl-1 downregulation, which, in turn, potentiates Bax activation and mitochondrial translocation, culminating in apoptosis.	Quercetin	37-46	BCL2 associated X, apoptosis regulator	Homo sapiens	252-255
21776474-7	2010	Co-stimulation of LPS with either quercetin, citrus pectin, or barley glucan in THP-1 monocytes and macrophages showed different immuno-modulatory activity of these compounds.	Quercetin	34-43	GLI family zinc finger 2	Homo sapiens	80-85
21062303-5	2010	Substrate selectivity could be demonstrated by inhibition studies with alpha-naphthoflavone (CYP1A), tranylcypromine/quercetine (CYP2C), quinidine (CYP2D), diethyldithiocarbamic acid (CYP2E) and ketoconazole (CYP3A) respectively.	Quercetin	117-127	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	129-134
20678173-5	2010	All HZ/trophozoite/15-HETE effects on MMP-9 activity and TNF/IL-1beta production were abrogated by quercetin, artemisinin and parthenolide, inhibitors of IkappaBalpha phosphorylation and subsequent degradation, NF-kappaB nuclear translocation, and NF-kappaB-p65 binding to DNA respectively.	Quercetin	99-108	matrix metallopeptidase 9	Homo sapiens	38-43
20678173-5	2010	All HZ/trophozoite/15-HETE effects on MMP-9 activity and TNF/IL-1beta production were abrogated by quercetin, artemisinin and parthenolide, inhibitors of IkappaBalpha phosphorylation and subsequent degradation, NF-kappaB nuclear translocation, and NF-kappaB-p65 binding to DNA respectively.	Quercetin	99-108	tumor necrosis factor	Homo sapiens	57-60
20678173-5	2010	All HZ/trophozoite/15-HETE effects on MMP-9 activity and TNF/IL-1beta production were abrogated by quercetin, artemisinin and parthenolide, inhibitors of IkappaBalpha phosphorylation and subsequent degradation, NF-kappaB nuclear translocation, and NF-kappaB-p65 binding to DNA respectively.	Quercetin	99-108	interleukin 1 beta	Homo sapiens	61-69
20678173-5	2010	All HZ/trophozoite/15-HETE effects on MMP-9 activity and TNF/IL-1beta production were abrogated by quercetin, artemisinin and parthenolide, inhibitors of IkappaBalpha phosphorylation and subsequent degradation, NF-kappaB nuclear translocation, and NF-kappaB-p65 binding to DNA respectively.	Quercetin	99-108	NFKB inhibitor alpha	Homo sapiens	154-166
21138867-0	2010	Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.	Quercetin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	70-75
21138867-0	2010	Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	94-97
21138867-1	2010	PURPOSE: To investigate the in vivo antitumor efficacy of quercetin in U937 xenografts and the functional roles of Mcl-1 and Bax in quercetin-induced apoptosis in human leukemia.	Quercetin	132-141	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	115-120
21138867-5	2010	Quercetin-induced apoptosis was accompanied by Mcl-1 downregulation and Bax conformational change and mitochondrial translocation that triggered cytochrome c release.	Quercetin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	47-52
21138867-5	2010	Quercetin-induced apoptosis was accompanied by Mcl-1 downregulation and Bax conformational change and mitochondrial translocation that triggered cytochrome c release.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
21138867-5	2010	Quercetin-induced apoptosis was accompanied by Mcl-1 downregulation and Bax conformational change and mitochondrial translocation that triggered cytochrome c release.	Quercetin	0-9	cytochrome c, somatic	Homo sapiens	145-157
21138867-6	2010	Knockdown of Bax by siRNA reversed quercetin-induced apoptosis and abrogated the activation of caspase and apoptosis.	Quercetin	35-44	BCL2 associated X, apoptosis regulator	Homo sapiens	13-16
21138867-7	2010	Ectopic expression of Mcl-1 attenuated quercetin-mediated Bax activation, translocation, and cell death.	Quercetin	39-48	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	22-27
21138867-7	2010	Ectopic expression of Mcl-1 attenuated quercetin-mediated Bax activation, translocation, and cell death.	Quercetin	39-48	BCL2 associated X, apoptosis regulator	Homo sapiens	58-61
21138867-8	2010	Conversely, interruption of Mcl-1 by siRNA enhanced Bax activation and translocation, as well as lethality induced by quercetin.	Quercetin	118-127	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	28-33
21138867-13	2010	CONCLUSIONS: These data suggest that quercetin may be useful for the treatment of leukemia by preferentially inducing apoptosis in leukemia versus normal hematopoietic cells through a process involving Mcl-1 downregulation, which, in turn, potentiates Bax activation and mitochondrial translocation, culminating in apoptosis.	Quercetin	37-46	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	202-207
21042744-0	2010	Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells.	Quercetin	69-78	AKT serine/threonine kinase 1	Homo sapiens	60-63
21042744-3	2010	Also the activation of AMPK with quercetin strongly abrogated Akt activities.	Quercetin	33-42	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	23-27
21042744-3	2010	Also the activation of AMPK with quercetin strongly abrogated Akt activities.	Quercetin	33-42	AKT serine/threonine kinase 1	Homo sapiens	62-65
21042744-5	2010	However, quercetin exerted Akt inhibitory activities in the absence of AMPK activation.	Quercetin	9-18	AKT serine/threonine kinase 1	Homo sapiens	27-30
21042744-6	2010	Quercetin induced partial co-localization of phospho-Akt and phospho-AMPK in the nucleus even though their interaction seems to be indirect since the immunoprecipitation data indicate there was no direct binding between total Akt and AMPK.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	53-56
21042744-6	2010	Quercetin induced partial co-localization of phospho-Akt and phospho-AMPK in the nucleus even though their interaction seems to be indirect since the immunoprecipitation data indicate there was no direct binding between total Akt and AMPK.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	69-73
21042744-6	2010	Quercetin induced partial co-localization of phospho-Akt and phospho-AMPK in the nucleus even though their interaction seems to be indirect since the immunoprecipitation data indicate there was no direct binding between total Akt and AMPK.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	226-229
21042744-6	2010	Quercetin induced partial co-localization of phospho-Akt and phospho-AMPK in the nucleus even though their interaction seems to be indirect since the immunoprecipitation data indicate there was no direct binding between total Akt and AMPK.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	234-238
21042744-8	2010	The investigation of mutual suppression between Akt and AMPK by chemo-preventive agents such as quercetin may provide a mechanistic rational for controlling breast tumor cell growth.	Quercetin	96-105	AKT serine/threonine kinase 1	Homo sapiens	48-51
21042744-8	2010	The investigation of mutual suppression between Akt and AMPK by chemo-preventive agents such as quercetin may provide a mechanistic rational for controlling breast tumor cell growth.	Quercetin	96-105	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	56-60
20440299-5	2010	RESULTS: In quercetin-treated animals, MPO activity was significantly decreased in tissue at 12 and 24 h and in serum at 6, 12 and 24 h after injury, compared with saline controls.	Quercetin	12-21	myeloperoxidase	Rattus norvegicus	39-42
20440299-6	2010	In quercetin-treated animals, the prevalence of ED-1 and MPO positive cells was significantly lower than in saline controls.	Quercetin	3-12	myeloperoxidase	Rattus norvegicus	57-60
20440299-9	2010	The resulting lower MPO release in the injured tissue is likely to decrease the extent of secondary injury and might at least partially explain the neuroprotective effect of the flavonoid quercetin.	Quercetin	188-197	myeloperoxidase	Rattus norvegicus	20-23
21108840-7	2010	CYT and quercetin, an active compound of CYT, significantly inhibited LPS-induced interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha production and expression in PBMCs.	Quercetin	8-17	interleukin 6	Homo sapiens	106-110
21108840-7	2010	CYT and quercetin, an active compound of CYT, significantly inhibited LPS-induced interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha production and expression in PBMCs.	Quercetin	8-17	tumor necrosis factor	Homo sapiens	116-149
21108840-8	2010	CYT and quercetin also inhibited LPS-induced nuclear translocation and DNA binding activities of nuclear factor-kappaB and degradation of IkappaBalpha.	Quercetin	8-17	NFKB inhibitor alpha	Homo sapiens	138-150
21108840-9	2010	In addition, CYT and quercetin inhibited LPS-induced IL-32 expression and caspase-1 activation.	Quercetin	21-30	interleukin 32	Homo sapiens	53-58
21108840-9	2010	In addition, CYT and quercetin inhibited LPS-induced IL-32 expression and caspase-1 activation.	Quercetin	21-30	caspase 1	Homo sapiens	74-83
20042712-0	2010	Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: potential use as a biomarker of DeltaF508 cystic fibrosis transmembrane conductance regulator rescue.	Quercetin	87-96	CF transmembrane conductance regulator	Homo sapiens	18-69
20042712-0	2010	Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: potential use as a biomarker of DeltaF508 cystic fibrosis transmembrane conductance regulator rescue.	Quercetin	87-96	CF transmembrane conductance regulator	Homo sapiens	140-191
20042712-4	2010	A screen of flavonoids in CFBE41o- cells stably transduced with DeltaF508 CFTR, corrected to the cell surface with low temperature growth, revealed that quercetin stimulated an increase in the short-circuit current.	Quercetin	153-162	CF transmembrane conductance regulator	Homo sapiens	74-78
20042712-3	2010	In this study, we identify an agent, quercetin, that enhances the detection of surface DeltaF508 CFTR, and is suitable for nasal perfusion.	Quercetin	37-46	CF transmembrane conductance regulator	Homo sapiens	97-101
20042712-7	2010	In CFBE41o- airway cells, quercetin (20 mug/ml) activated DeltaF508 CFTR, whereas the beta2 adrenergic receptor agonist isoproterenol did not.	Quercetin	26-35	CF transmembrane conductance regulator	Homo sapiens	68-72
21787659-5	2010	Furthermore, quercetin markedly restored Cu/Zn-SOD, CAT and GPx activities in the kidney of lead-treated rat.	Quercetin	13-22	superoxide dismutase 1	Rattus norvegicus	41-50
20042712-9	2010	When perfused in the nares of Cftr(+) mice, quercetin (20 mug/ml) produced a hyperpolarization of the potential difference that was absent in Cftr(-/-) mice.	Quercetin	44-53	CF transmembrane conductance regulator	Homo sapiens	30-34
20042712-9	2010	When perfused in the nares of Cftr(+) mice, quercetin (20 mug/ml) produced a hyperpolarization of the potential difference that was absent in Cftr(-/-) mice.	Quercetin	44-53	cystic fibrosis transmembrane conductance regulator	Mus musculus	142-146
20042712-11	2010	Quercetin activates CFTR-mediated anion transport in respiratory epithelia in vitro and in vivo, and may be useful in studies intended to detect the rescue of DeltaF508 CFTR by nasal potential difference.	Quercetin	0-9	CF transmembrane conductance regulator	Homo sapiens	20-24
20042712-11	2010	Quercetin activates CFTR-mediated anion transport in respiratory epithelia in vitro and in vivo, and may be useful in studies intended to detect the rescue of DeltaF508 CFTR by nasal potential difference.	Quercetin	0-9	CF transmembrane conductance regulator	Homo sapiens	169-173
19608276-3	2010	Previous studies from our group have shown that quercetin, a nutritionally relevant flavonoid can significantly reduce PCB77 induction of oxidative stress and expression of the AHR responsive gene cytochrome P450 1A1 (CYP1A1).	Quercetin	48-57	aryl hydrocarbon receptor	Homo sapiens	177-180
19608276-3	2010	Previous studies from our group have shown that quercetin, a nutritionally relevant flavonoid can significantly reduce PCB77 induction of oxidative stress and expression of the AHR responsive gene cytochrome P450 1A1 (CYP1A1).	Quercetin	48-57	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	197-216
19608276-3	2010	Previous studies from our group have shown that quercetin, a nutritionally relevant flavonoid can significantly reduce PCB77 induction of oxidative stress and expression of the AHR responsive gene cytochrome P450 1A1 (CYP1A1).	Quercetin	48-57	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	218-224
19608276-5	2010	Thus, we hypothesized that quercetin can modulate PCB-induced endothelial inflammation associated with caveolae.	Quercetin	27-36	pyruvate carboxylase	Homo sapiens	50-53
19608276-7	2010	Quercetin co-treatment significantly blocked both PCB77 and PCB126 induction of CYP1A1, vascular cell adhesion molecule 1 (VCAM-1), E-selectin and P-selectin.	Quercetin	0-9	pyruvate carboxylase	Homo sapiens	50-53
19608276-7	2010	Quercetin co-treatment significantly blocked both PCB77 and PCB126 induction of CYP1A1, vascular cell adhesion molecule 1 (VCAM-1), E-selectin and P-selectin.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	80-86
19608276-7	2010	Quercetin co-treatment significantly blocked both PCB77 and PCB126 induction of CYP1A1, vascular cell adhesion molecule 1 (VCAM-1), E-selectin and P-selectin.	Quercetin	0-9	vascular cell adhesion molecule 1	Homo sapiens	88-121
19608276-7	2010	Quercetin co-treatment significantly blocked both PCB77 and PCB126 induction of CYP1A1, vascular cell adhesion molecule 1 (VCAM-1), E-selectin and P-selectin.	Quercetin	0-9	vascular cell adhesion molecule 1	Homo sapiens	123-129
19608276-7	2010	Quercetin co-treatment significantly blocked both PCB77 and PCB126 induction of CYP1A1, vascular cell adhesion molecule 1 (VCAM-1), E-selectin and P-selectin.	Quercetin	0-9	selectin E	Homo sapiens	132-142
19608276-7	2010	Quercetin co-treatment significantly blocked both PCB77 and PCB126 induction of CYP1A1, vascular cell adhesion molecule 1 (VCAM-1), E-selectin and P-selectin.	Quercetin	0-9	selectin P	Homo sapiens	147-157
19608276-8	2010	Exposure to PCB77 also induced caveolin-1 protein expression, which was reduced by co-treatment with quercetin.	Quercetin	101-110	caveolin 1	Homo sapiens	31-41
20977456-10	2010	The CYP3A inhibitors ketoconazole and troleandomycin, and the CYP2C8 inhibitors quercetin and paclitaxel decreased imatinib oxidation.	Quercetin	80-89	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	62-68
21787659-5	2010	Furthermore, quercetin markedly restored Cu/Zn-SOD, CAT and GPx activities in the kidney of lead-treated rat.	Quercetin	13-22	catalase	Rattus norvegicus	52-55
22993618-0	2010	Quercetin and sulforaphane in combination suppress the progression of melanoma through the down-regulation of matrix metalloproteinase-9.	Quercetin	0-9	matrix metallopeptidase 9	Mus musculus	110-136
20804812-3	2010	Among six flavonoids tested in the current study, VEGF gene transcription in MCF-7 cells with stable Pin1 overexpression was inhibited most effectively by quercetin.	Quercetin	155-164	vascular endothelial growth factor A	Homo sapiens	50-54
20804812-3	2010	Among six flavonoids tested in the current study, VEGF gene transcription in MCF-7 cells with stable Pin1 overexpression was inhibited most effectively by quercetin.	Quercetin	155-164	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	101-105
20804812-4	2010	Reporter gene assays using minimal reporters containing hypoxia response elements and activator protein-1 (AP-1) elements revealed that the activities of hypoxia inducible factor-1alpha (HIF-1alpha) and AP-1, key transcription factors for VEGF gene transcription, were suppressed by quercetin.	Quercetin	283-292	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-111
20804812-4	2010	Reporter gene assays using minimal reporters containing hypoxia response elements and activator protein-1 (AP-1) elements revealed that the activities of hypoxia inducible factor-1alpha (HIF-1alpha) and AP-1, key transcription factors for VEGF gene transcription, were suppressed by quercetin.	Quercetin	283-292	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-185
20804812-4	2010	Reporter gene assays using minimal reporters containing hypoxia response elements and activator protein-1 (AP-1) elements revealed that the activities of hypoxia inducible factor-1alpha (HIF-1alpha) and AP-1, key transcription factors for VEGF gene transcription, were suppressed by quercetin.	Quercetin	283-292	hypoxia inducible factor 1 subunit alpha	Homo sapiens	187-197
20658310-4	2010	Quercetin induced caspase-3 activity assay was performed for activation of apoptosis.	Quercetin	0-9	caspase 3	Homo sapiens	18-27
20804812-4	2010	Reporter gene assays using minimal reporters containing hypoxia response elements and activator protein-1 (AP-1) elements revealed that the activities of hypoxia inducible factor-1alpha (HIF-1alpha) and AP-1, key transcription factors for VEGF gene transcription, were suppressed by quercetin.	Quercetin	283-292	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-207
20804812-5	2010	Western blot analyses confirmed that the increased nuclear levels of c-Jun and HIF-1alpha in TAMR-MCF-7 cells were blocked by quercetin.	Quercetin	126-135	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-74
20804812-5	2010	Western blot analyses confirmed that the increased nuclear levels of c-Jun and HIF-1alpha in TAMR-MCF-7 cells were blocked by quercetin.	Quercetin	126-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
20804812-6	2010	Moreover, quercetin inhibited the enhanced VEGF secretion and Pin1 expression in TAMR-MCF-7 cells, which was dependent on its phosphatidyl inositol 3-kinase inhibiting effect.	Quercetin	10-19	vascular endothelial growth factor A	Homo sapiens	43-47
20804812-6	2010	Moreover, quercetin inhibited the enhanced VEGF secretion and Pin1 expression in TAMR-MCF-7 cells, which was dependent on its phosphatidyl inositol 3-kinase inhibiting effect.	Quercetin	10-19	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	62-66
20804812-8	2010	These results demonstrate that quercetin may have therapeutic potential for the treatment of TAM-resistant breast cancer via Pin1 inhibition.	Quercetin	31-40	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	125-129
20658310-6	2010	Quercetin significantly increases the proapoptotic mRNA levels of Bad, IGFBP-3 and protein levels of Bad, cytochrome C, cleaved caspase-9, caspase-10, cleaved PARP and caspase-3 activity in PC-3 cells.	Quercetin	0-9	insulin like growth factor binding protein 3	Homo sapiens	71-78
20658310-6	2010	Quercetin significantly increases the proapoptotic mRNA levels of Bad, IGFBP-3 and protein levels of Bad, cytochrome C, cleaved caspase-9, caspase-10, cleaved PARP and caspase-3 activity in PC-3 cells.	Quercetin	0-9	cytochrome c, somatic	Homo sapiens	106-118
20658310-6	2010	Quercetin significantly increases the proapoptotic mRNA levels of Bad, IGFBP-3 and protein levels of Bad, cytochrome C, cleaved caspase-9, caspase-10, cleaved PARP and caspase-3 activity in PC-3 cells.	Quercetin	0-9	caspase 9	Homo sapiens	128-137
20658310-6	2010	Quercetin significantly increases the proapoptotic mRNA levels of Bad, IGFBP-3 and protein levels of Bad, cytochrome C, cleaved caspase-9, caspase-10, cleaved PARP and caspase-3 activity in PC-3 cells.	Quercetin	0-9	caspase 10	Homo sapiens	139-149
20658310-6	2010	Quercetin significantly increases the proapoptotic mRNA levels of Bad, IGFBP-3 and protein levels of Bad, cytochrome C, cleaved caspase-9, caspase-10, cleaved PARP and caspase-3 activity in PC-3 cells.	Quercetin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	159-163
20658310-6	2010	Quercetin significantly increases the proapoptotic mRNA levels of Bad, IGFBP-3 and protein levels of Bad, cytochrome C, cleaved caspase-9, caspase-10, cleaved PARP and caspase-3 activity in PC-3 cells.	Quercetin	0-9	caspase 3	Homo sapiens	168-177
20658310-8	2010	Further, treatment with PI3K inhibitor (LY294002) and quercetin showed decreased p-Akt levels.	Quercetin	54-63	AKT serine/threonine kinase 1	Homo sapiens	83-86
20828797-2	2010	Myricetin and quercetin have shown to be the best thrombin inhibitors tested.	Quercetin	14-23	coagulation factor II, thrombin	Homo sapiens	50-58
20626032-0	2010	Upstream stimulatory factor-2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells.	Quercetin	39-48	upstream transcription factor 2, c-fos interacting	Homo sapiens	0-29
20719748-3	2010	Here, inhibition of recombinant human alpha1 GlyRs in HEK 293 cells by genistein, quercetin, and strychnine was studied using whole-cell recording techniques.	Quercetin	82-91	glycine receptor alpha 1	Homo sapiens	38-50
21355274-3	2010	The flow rate was 1 mL x min(-1), the detection wavelength was 360 nm; and the column temperature was set at 25 degrees C. RESULT: The linear ranges of quercetin and kaempferol are 0.22-1.1 microg and 0.42-2.1 microg.	Quercetin	152-161	CD59 molecule (CD59 blood group)	Homo sapiens	25-31
20626032-0	2010	Upstream stimulatory factor-2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells.	Quercetin	39-48	serpin family E member 1	Homo sapiens	72-77
20626032-1	2010	The polyphenol quercetin (Quer) represses expression of the cardiovascular disease risk factor plasminogen activator inhibitor-1 (PAI-1) in cultured endothelial cells (ECs).	Quercetin	15-24	serpin family E member 1	Homo sapiens	95-128
20626032-1	2010	The polyphenol quercetin (Quer) represses expression of the cardiovascular disease risk factor plasminogen activator inhibitor-1 (PAI-1) in cultured endothelial cells (ECs).	Quercetin	15-24	serpin family E member 1	Homo sapiens	130-135
20626032-1	2010	The polyphenol quercetin (Quer) represses expression of the cardiovascular disease risk factor plasminogen activator inhibitor-1 (PAI-1) in cultured endothelial cells (ECs).	Quercetin	26-30	serpin family E member 1	Homo sapiens	95-128
20626032-1	2010	The polyphenol quercetin (Quer) represses expression of the cardiovascular disease risk factor plasminogen activator inhibitor-1 (PAI-1) in cultured endothelial cells (ECs).	Quercetin	26-30	serpin family E member 1	Homo sapiens	130-135
20619256-4	2010	Herein, we first evaluated the inhibitory effect of quercetin on MMP-9 activity by zymography and a fluorescent gelatin dequenching assay, secondly we determined the most probable sites and modes of quercetin interaction with the MMP-9 catalytic domain by using molecular modelling techniques, and finally, we investigated the structure-activity relationship of the inhibitory effect of flavonoids on MMP-9 activity.	Quercetin	52-61	matrix metallopeptidase 9	Homo sapiens	65-70
20619256-4	2010	Herein, we first evaluated the inhibitory effect of quercetin on MMP-9 activity by zymography and a fluorescent gelatin dequenching assay, secondly we determined the most probable sites and modes of quercetin interaction with the MMP-9 catalytic domain by using molecular modelling techniques, and finally, we investigated the structure-activity relationship of the inhibitory effect of flavonoids on MMP-9 activity.	Quercetin	199-208	matrix metallopeptidase 9	Homo sapiens	230-235
20619256-0	2010	Inhibitory effect of quercetin on matrix metalloproteinase 9 activity molecular mechanism and structure-activity relationship of the flavonoid-enzyme interaction.	Quercetin	21-30	matrix metallopeptidase 9	Homo sapiens	34-60
20619256-4	2010	Herein, we first evaluated the inhibitory effect of quercetin on MMP-9 activity by zymography and a fluorescent gelatin dequenching assay, secondly we determined the most probable sites and modes of quercetin interaction with the MMP-9 catalytic domain by using molecular modelling techniques, and finally, we investigated the structure-activity relationship of the inhibitory effect of flavonoids on MMP-9 activity.	Quercetin	199-208	matrix metallopeptidase 9	Homo sapiens	230-235
20619256-5	2010	We show that quercetin inhibited MMP-9 activity with an IC(50) value of 22 microM.	Quercetin	13-22	matrix metallopeptidase 9	Homo sapiens	33-38
20619256-6	2010	By using docking and molecular dynamics simulations, it was shown that quercetin interacted in the S1" subsite of the MMP-9 active site.	Quercetin	71-80	matrix metallopeptidase 9	Homo sapiens	118-123
20619256-8	2010	In conclusion, our data constitute the first evidence about the quercetin and MMP-9 interaction, suggesting a mechanism to explain the inhibitory effect of the flavonoid on the enzymatic activity of MMP-9, which provides an additional molecular target for the cardioprotective activity of quercetin.	Quercetin	64-73	matrix metallopeptidase 9	Homo sapiens	199-204
20619256-8	2010	In conclusion, our data constitute the first evidence about the quercetin and MMP-9 interaction, suggesting a mechanism to explain the inhibitory effect of the flavonoid on the enzymatic activity of MMP-9, which provides an additional molecular target for the cardioprotective activity of quercetin.	Quercetin	289-298	matrix metallopeptidase 9	Homo sapiens	78-83
20619256-8	2010	In conclusion, our data constitute the first evidence about the quercetin and MMP-9 interaction, suggesting a mechanism to explain the inhibitory effect of the flavonoid on the enzymatic activity of MMP-9, which provides an additional molecular target for the cardioprotective activity of quercetin.	Quercetin	289-298	matrix metallopeptidase 9	Homo sapiens	199-204
20654599-4	2010	At a low (5muM) drug concentration, quercetin potentiated a pro-autophagic effect of Temozolomide, while after treatment with a higher drug concentration (30muM), autophagy switched to apoptosis.	Quercetin	36-45	latexin	Homo sapiens	11-14
20406213-2	2010	Here, we tested the hypothesis that chronic quercetin treatment inhibits the angiotensin-converting enzyme (ACE).	Quercetin	44-53	angiotensin I converting enzyme	Rattus norvegicus	77-106
20406213-2	2010	Here, we tested the hypothesis that chronic quercetin treatment inhibits the angiotensin-converting enzyme (ACE).	Quercetin	44-53	angiotensin I converting enzyme	Rattus norvegicus	108-111
20860660-0	2010	Quercetin potentiates insulin secretion and protects INS-1 pancreatic beta-cells against oxidative damage via the ERK1/2 pathway.	Quercetin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	114-120
20860660-8	2010	KEY RESULTS Quercetin (20 micromol L(-1)) potentiated both glucose (8.3 mmol L(-1))- and glibenclamide (0.01 micromol L(-1))-induced insulin secretion and ERK1/2 phosphorylation.	Quercetin	12-21	mitogen activated protein kinase 3	Rattus norvegicus	155-161
20860660-9	2010	The ERK1/2 (but not the protein kinase A) signalling pathway played a crucial role in the potentiation of glucose-induced insulin secretion by quercetin.	Quercetin	143-152	mitogen activated protein kinase 3	Rattus norvegicus	4-10
20860660-10	2010	In addition, quercetin (20 micromol L(-1)), protected beta-cell function and viability against oxidative damage induced by 50 micromol L(-1) H(2)O(2) and induced a major phosphorylation of ERK1/2.	Quercetin	13-22	mitogen activated protein kinase 3	Rattus norvegicus	189-195
20383790-1	2010	OBJECTIVE: We investigated the inhibitory effects of quercetin and kaempferol treatment on the suppression of immunoglobulin E (IgE)-mediated allergic responses in relation to intestinal epithelium barrier function in RBL-2H3 and Caco-2 cells.	Quercetin	53-62	immunoglobulin heavy constant epsilon	Homo sapiens	128-131
20606002-7	2010	It was observed that there was a positive correlation (r = 0.760) between the sensitivity of the human placental COMT to heat inactivation and its sensitivity to inhibition by (-)-epigallocatechin-3-gallate (a well known tea polyphenol with COMT-inhibiting activity) but an inverse correlation (r = 0.544) between heat inactivation and inhibition by quercetin (another dietary COMT inhibitor).	Quercetin	350-359	catechol-O-methyltransferase	Homo sapiens	113-117
20619334-7	2010	In this study, we have identified quercetin (QUER) and its derivative, namely quercetin caprylate (QU-CAP) as a proteasome activator with anti-oxidant properties that consequently influence cellular lifespan, survival and viability of HFL-1 primary human fibroblasts.	Quercetin	34-43	complement factor H related 1	Homo sapiens	235-240
20849592-7	2010	RESULTS: Quercetin inhibited the expression of CD63 and CD203c and the histamine release in basophils activated with anti-IgE or with the ionophore: the IC50 in the anti-IgE model was higher than in the ionophore model and the effects were more pronounced for CD63 than for CD203c.	Quercetin	9-18	CD63 molecule	Homo sapiens	47-51
20690163-0	2010	Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity.	Quercetin	0-9	protein phosphatase 1 (formerly 2C)-like	Mus musculus	61-65
20690163-7	2010	Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation.	Quercetin	13-22	protein phosphatase 1 (formerly 2C)-like	Mus musculus	123-137
20690163-7	2010	Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation.	Quercetin	13-22	protein phosphatase 1 (formerly 2C)-like	Mus musculus	139-143
20690163-7	2010	Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation.	Quercetin	13-22	integrin alpha M	Mus musculus	228-233
20690163-7	2010	Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation.	Quercetin	13-22	nitric oxide synthase 2, inducible	Mus musculus	261-265
20690163-7	2010	Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation.	Quercetin	13-22	prostaglandin-endoperoxide synthase 2	Mus musculus	270-286
20690163-7	2010	Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation.	Quercetin	13-22	prostaglandin-endoperoxide synthase 2	Mus musculus	288-293
20690163-7	2010	Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation.	Quercetin	13-22	interleukin 1 alpha	Mus musculus	321-329
20690163-7	2010	Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation.	Quercetin	13-22	interleukin 6	Mus musculus	331-335
20690163-7	2010	Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation.	Quercetin	13-22	tumor necrosis factor	Mus musculus	341-350
20542118-0	2010	Quercetin attenuates Monocyte Chemoattractant Protein-1 gene expression in glucose primed aortic endothelial cells through NF-kappaB and AP-1.	Quercetin	0-9	chemokine (C-C motif) ligand 2	Mus musculus	21-55
20542118-0	2010	Quercetin attenuates Monocyte Chemoattractant Protein-1 gene expression in glucose primed aortic endothelial cells through NF-kappaB and AP-1.	Quercetin	0-9	jun proto-oncogene	Mus musculus	137-141
20542118-3	2010	We hypothesized that quercetin, an anti-inflammatory molecule could modulate high glucose concentration (HG) induced MCP-1 expression in aortic endothelial cells in vitro because of its regulatory effects on Activator Protein-1 (AP-1) and Nuclear Factor-kappaB (NF-kappaB).	Quercetin	21-30	chemokine (C-C motif) ligand 2	Mus musculus	117-122
20542118-3	2010	We hypothesized that quercetin, an anti-inflammatory molecule could modulate high glucose concentration (HG) induced MCP-1 expression in aortic endothelial cells in vitro because of its regulatory effects on Activator Protein-1 (AP-1) and Nuclear Factor-kappaB (NF-kappaB).	Quercetin	21-30	jun proto-oncogene	Mus musculus	208-227
20542118-3	2010	We hypothesized that quercetin, an anti-inflammatory molecule could modulate high glucose concentration (HG) induced MCP-1 expression in aortic endothelial cells in vitro because of its regulatory effects on Activator Protein-1 (AP-1) and Nuclear Factor-kappaB (NF-kappaB).	Quercetin	21-30	jun proto-oncogene	Mus musculus	229-233
20542118-5	2010	Quercetin attenuated HG induced MCP-1 mRNA (42%) and protein synthesis (45%) when estimated using real-time reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay respectively.	Quercetin	0-9	chemokine (C-C motif) ligand 2	Mus musculus	32-37
20542118-6	2010	Western blot analysis found quercetin to maintain cytosolic p65 protein levels to that seen in control.	Quercetin	28-37	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	60-63
20542118-7	2010	Quercetin was found to attenuate HG induced increased NF-kappaB and AP-1 DNA binding activity in electrophoretic mobility shift assay.	Quercetin	0-9	jun proto-oncogene	Mus musculus	68-72
20542118-8	2010	Immunofluorescence studies revealed quercetin to prevent HG induced nuclear localization of p65 and c-jun.	Quercetin	36-45	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	92-95
20542118-8	2010	Immunofluorescence studies revealed quercetin to prevent HG induced nuclear localization of p65 and c-jun.	Quercetin	36-45	jun proto-oncogene	Mus musculus	100-105
20542118-9	2010	Quercetin was also found to decrease HG induced activation of NF-kappaB (71%+/-14%), AP-1 (69%+/-24%) and MCP-1 promoter (79%+/-25%) in EA.hy926 cells when analyzed using luciferase reporter assay.	Quercetin	0-9	jun proto-oncogene	Mus musculus	85-89
20542118-9	2010	Quercetin was also found to decrease HG induced activation of NF-kappaB (71%+/-14%), AP-1 (69%+/-24%) and MCP-1 promoter (79%+/-25%) in EA.hy926 cells when analyzed using luciferase reporter assay.	Quercetin	0-9	chemokine (C-C motif) ligand 2	Mus musculus	106-111
20542118-10	2010	We conclude that quercetin attenuates MCP-1 expression in HG treated RAECs, probably by regulating both NF-kappaB and AP-1 pathways.	Quercetin	17-26	chemokine (C-C motif) ligand 2	Mus musculus	38-43
20542118-10	2010	We conclude that quercetin attenuates MCP-1 expression in HG treated RAECs, probably by regulating both NF-kappaB and AP-1 pathways.	Quercetin	17-26	jun proto-oncogene	Mus musculus	118-122
20920189-0	2010	Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression.	Quercetin	0-9	toll-like receptor 4	Mus musculus	54-57
20920189-4	2010	We hypothesized that quercetin reduces lung inflammation and improves lung function in elastase/lipopolysaccharide (LPS)-exposed mice which show typical features of COPD, including airways inflammation, goblet cell metaplasia, and emphysema.	Quercetin	21-30	toll-like receptor 4	Mus musculus	87-114
20920189-4	2010	We hypothesized that quercetin reduces lung inflammation and improves lung function in elastase/lipopolysaccharide (LPS)-exposed mice which show typical features of COPD, including airways inflammation, goblet cell metaplasia, and emphysema.	Quercetin	21-30	toll-like receptor 4	Mus musculus	116-119
20920189-8	2010	RESULTS: Quercetin-treated, elastase/LPS-exposed mice showed improved elastic recoil and decreased alveolar chord length compared to vehicle-treated controls.	Quercetin	9-18	toll-like receptor 4	Mus musculus	37-40
20920189-10	2010	Quercetin also reduced lung inflammation, goblet cell metaplasia, and mRNA expression of pro-inflammatory cytokines and muc5AC.	Quercetin	0-9	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	120-126
20920189-11	2010	Quercetin treatment decreased the expression and activity of MMP9 and MMP12 in vivo and in vitro, while increasing expression of the histone deacetylase Sirt-1 and suppressing MMP promoter H4 acetylation.	Quercetin	0-9	matrix metallopeptidase 9	Mus musculus	61-65
20920189-11	2010	Quercetin treatment decreased the expression and activity of MMP9 and MMP12 in vivo and in vitro, while increasing expression of the histone deacetylase Sirt-1 and suppressing MMP promoter H4 acetylation.	Quercetin	0-9	matrix metallopeptidase 12	Mus musculus	70-75
20920189-11	2010	Quercetin treatment decreased the expression and activity of MMP9 and MMP12 in vivo and in vitro, while increasing expression of the histone deacetylase Sirt-1 and suppressing MMP promoter H4 acetylation.	Quercetin	0-9	sirtuin 1	Mus musculus	153-159
20920189-12	2010	Finally, co-treatment with the Sirt-1 inhibitor sirtinol blocked the effects of quercetin on the lung phenotype.	Quercetin	80-89	sirtuin 1	Mus musculus	31-37
20920189-13	2010	CONCLUSIONS: Quercetin prevents progression of emphysema in elastase/LPS-treated mice by reducing oxidative stress, lung inflammation and expression of MMP9 and MMP12.	Quercetin	13-22	toll-like receptor 4	Mus musculus	69-72
20920189-13	2010	CONCLUSIONS: Quercetin prevents progression of emphysema in elastase/LPS-treated mice by reducing oxidative stress, lung inflammation and expression of MMP9 and MMP12.	Quercetin	13-22	matrix metallopeptidase 9	Mus musculus	152-156
20920189-13	2010	CONCLUSIONS: Quercetin prevents progression of emphysema in elastase/LPS-treated mice by reducing oxidative stress, lung inflammation and expression of MMP9 and MMP12.	Quercetin	13-22	matrix metallopeptidase 12	Mus musculus	161-166
20849592-7	2010	RESULTS: Quercetin inhibited the expression of CD63 and CD203c and the histamine release in basophils activated with anti-IgE or with the ionophore: the IC50 in the anti-IgE model was higher than in the ionophore model and the effects were more pronounced for CD63 than for CD203c.	Quercetin	9-18	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	56-62
20849592-7	2010	RESULTS: Quercetin inhibited the expression of CD63 and CD203c and the histamine release in basophils activated with anti-IgE or with the ionophore: the IC50 in the anti-IgE model was higher than in the ionophore model and the effects were more pronounced for CD63 than for CD203c.	Quercetin	9-18	CD63 molecule	Homo sapiens	260-264
20849592-7	2010	RESULTS: Quercetin inhibited the expression of CD63 and CD203c and the histamine release in basophils activated with anti-IgE or with the ionophore: the IC50 in the anti-IgE model was higher than in the ionophore model and the effects were more pronounced for CD63 than for CD203c.	Quercetin	9-18	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	274-280
20849592-8	2010	Nanomolar concentrations of quercetin were able to prime both markers expression and histamine release in the fMLP activation model while no effect of quercetin was observed when basophils were activated with PMA.	Quercetin	28-37	formyl peptide receptor 1	Homo sapiens	110-114
20849592-9	2010	The specific phosphoinositide-3 kinase (PI3K) inhibitor wortmannin exhibited the same behavior of quercetin in anti-IgE and fMLP activation, thus suggesting a role for PI3K involvement in the priming mechanism.	Quercetin	98-107	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	13-38
20580672-9	2010	Adiponectin stimulating effects of quercetin are PPAR-gamma-independent and prevent impairment of insulin sensitivity without affecting body weight and composition.	Quercetin	35-44	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	0-11
20580672-0	2010	Quercetin enhances adiponectin secretion by a PPAR-gamma independent mechanism.	Quercetin	0-9	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	19-30
20510684-10	2010	Histopathological assessment revealed that treatment with liposomal quercetin apparently lessened the lung fibrosis areas and collagen deposition accompanied with decreased expression of TGF-beta1.	Quercetin	68-77	transforming growth factor beta 1	Homo sapiens	187-196
20580672-9	2010	Adiponectin stimulating effects of quercetin are PPAR-gamma-independent and prevent impairment of insulin sensitivity without affecting body weight and composition.	Quercetin	35-44	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	49-59
20580672-0	2010	Quercetin enhances adiponectin secretion by a PPAR-gamma independent mechanism.	Quercetin	0-9	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	46-56
20944129-3	2010	The aim of the study was to investigate the effects of increasing concentrations of quercetin (from 0.1 to 100 muM) on polyamine biosynthesis, cell proliferation, and apoptosis in the DLD-1 cells.	Quercetin	84-93	latexin	Homo sapiens	111-114
20586760-0	2010	Quercetin and ethanol attenuate the progression of atherosclerotic plaques with concomitant up regulation of paraoxonase1 (PON1) gene expression and PON1 activity in LDLR-/- mice.	Quercetin	0-9	paraoxonase 1	Mus musculus	109-121
20586760-0	2010	Quercetin and ethanol attenuate the progression of atherosclerotic plaques with concomitant up regulation of paraoxonase1 (PON1) gene expression and PON1 activity in LDLR-/- mice.	Quercetin	0-9	paraoxonase 1	Mus musculus	123-127
20586760-0	2010	Quercetin and ethanol attenuate the progression of atherosclerotic plaques with concomitant up regulation of paraoxonase1 (PON1) gene expression and PON1 activity in LDLR-/- mice.	Quercetin	0-9	paraoxonase 1	Mus musculus	149-153
20586760-0	2010	Quercetin and ethanol attenuate the progression of atherosclerotic plaques with concomitant up regulation of paraoxonase1 (PON1) gene expression and PON1 activity in LDLR-/- mice.	Quercetin	0-9	low density lipoprotein receptor	Mus musculus	166-170
20586760-8	2010	CONCLUSIONS: Based on these findings, we conclude that quercetin and moderate ethanol significantly inhibit the progression of atherosclerosis by up regulating the hepatic expression of the antiatherogenic gene, PON1, with concomitant increased serum PON1 activity.	Quercetin	55-64	paraoxonase 1	Mus musculus	212-216
20586760-8	2010	CONCLUSIONS: Based on these findings, we conclude that quercetin and moderate ethanol significantly inhibit the progression of atherosclerosis by up regulating the hepatic expression of the antiatherogenic gene, PON1, with concomitant increased serum PON1 activity.	Quercetin	55-64	paraoxonase 1	Mus musculus	251-255
20944129-7	2010	RESULTS: At concentrations &gt;=50 muM, quercetin significantly reduced ornithine decarboxylase activity, putrescine and spermidine levels compared to controls and cells treated with 0.1 muM concentration.	Quercetin	40-49	latexin	Homo sapiens	35-38
20944129-7	2010	RESULTS: At concentrations &gt;=50 muM, quercetin significantly reduced ornithine decarboxylase activity, putrescine and spermidine levels compared to controls and cells treated with 0.1 muM concentration.	Quercetin	40-49	ornithine decarboxylase 1	Homo sapiens	72-95
20944129-7	2010	RESULTS: At concentrations &gt;=50 muM, quercetin significantly reduced ornithine decarboxylase activity, putrescine and spermidine levels compared to controls and cells treated with 0.1 muM concentration.	Quercetin	40-49	latexin	Homo sapiens	187-190
20944129-8	2010	Quercetin concentrations &gt;=70 muM caused a significant reduction in the conversion of MTT tetrazolium salt and [(3)H]-thymidine incorporation.	Quercetin	0-9	latexin	Homo sapiens	33-36
20100066-5	2010	Quercetin also suppressed the Ag-induced degranulation and phosphorylation of Syk but did not reduce the expression of FcepsilonRI on RBL-2H3 cells.	Quercetin	0-9	spleen associated tyrosine kinase	Rattus norvegicus	78-81
20554019-0	2010	After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult.	Quercetin	32-41	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
20554019-3	2010	We focused on quercetin modulation of thiol-redox systems by evaluating changes in mitochondrial thioredoxin Trx2, the levels of total glutathione (GSH), and the expression of the gamma-glutamate-cysteine ligase catalytic subunit (GCLC), the rate-limiting enzyme of GSH synthesis, by the use of Western blot, HPLC, and real-time PCR techniques, respectively.	Quercetin	14-23	glutamate-cysteine ligase catalytic subunit	Homo sapiens	180-229
20554019-3	2010	We focused on quercetin modulation of thiol-redox systems by evaluating changes in mitochondrial thioredoxin Trx2, the levels of total glutathione (GSH), and the expression of the gamma-glutamate-cysteine ligase catalytic subunit (GCLC), the rate-limiting enzyme of GSH synthesis, by the use of Western blot, HPLC, and real-time PCR techniques, respectively.	Quercetin	14-23	glutamate-cysteine ligase catalytic subunit	Homo sapiens	231-235
20554019-4	2010	We further explored the activation of the protective NF-E2-related factor 2 (Nrf2)-dependent signaling pathway by quercetin using immunocytochemistry techniques.	Quercetin	114-123	NFE2 like bZIP transcription factor 2	Homo sapiens	53-75
20554019-4	2010	We further explored the activation of the protective NF-E2-related factor 2 (Nrf2)-dependent signaling pathway by quercetin using immunocytochemistry techniques.	Quercetin	114-123	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
20554019-9	2010	Our findings suggest alternative mechanisms of quercetin neuroprotection beyond its long-established ROS scavenging properties, involving Nrf2-dependent modulation of the GSH redox system.	Quercetin	47-56	NFE2 like bZIP transcription factor 2	Homo sapiens	138-142
20100066-6	2010	These results suggest that inhibition of the Ag-induced degranulation and Syk phosphorylation by N-FGM might be due to the action of quercetin, as an active component in N-FGM.	Quercetin	133-142	spleen associated tyrosine kinase	Rattus norvegicus	74-77
20664924-4	2010	Quercetin diminished ALDH1 activity and reverted apoptosis resistance as detected by substrate assays, FACS and Western blot analysis.	Quercetin	0-9	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	21-26
20685402-4	2010	Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression.	Quercetin	45-54	interleukin 1 beta	Rattus norvegicus	164-173
20685402-4	2010	Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression.	Quercetin	45-54	mitogen activated protein kinase 3	Rattus norvegicus	118-124
20685402-4	2010	Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression.	Quercetin	45-54	mitogen-activated protein kinase 8	Rattus norvegicus	126-129
20685402-4	2010	Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression.	Quercetin	45-54	mitogen activated protein kinase 14	Rattus norvegicus	131-134
20685402-4	2010	Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression.	Quercetin	45-54	AKT serine/threonine kinase 1	Rattus norvegicus	140-143
20664924-4	2010	Quercetin diminished ALDH1 activity and reverted apoptosis resistance as detected by substrate assays, FACS and Western blot analysis.	Quercetin	0-9	acyl-CoA synthetase long-chain family member 1	Mus musculus	103-107
20664924-6	2010	Although quercetin led to enhanced binding of the survival factor NF-kappaB, co-incubation with sulforaphane completely eliminated this pro-proliferative feature.	Quercetin	9-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
20728021-0	2010	Quercetin up-regulates paraoxonase 1 gene expression via sterol regulatory element binding protein 2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in paraoxonase 1 promoter in HuH7 liver cells.	Quercetin	0-9	paraoxonase 1	Homo sapiens	23-36
21535545-5	2010	Quercetin and luteolin showed the strongest inhibitory activities on 15-lipoxygenase (LOX), and quercetin showed relatively potent inhibition on cyclooxygenase-1 (COX-1) reaction.	Quercetin	0-9	arachidonate 15-lipoxygenase	Homo sapiens	69-84
21535545-5	2010	Quercetin and luteolin showed the strongest inhibitory activities on 15-lipoxygenase (LOX), and quercetin showed relatively potent inhibition on cyclooxygenase-1 (COX-1) reaction.	Quercetin	0-9	arachidonate 15-lipoxygenase	Homo sapiens	86-89
21535545-5	2010	Quercetin and luteolin showed the strongest inhibitory activities on 15-lipoxygenase (LOX), and quercetin showed relatively potent inhibition on cyclooxygenase-1 (COX-1) reaction.	Quercetin	96-105	prostaglandin-endoperoxide synthase 1	Homo sapiens	145-161
21535545-5	2010	Quercetin and luteolin showed the strongest inhibitory activities on 15-lipoxygenase (LOX), and quercetin showed relatively potent inhibition on cyclooxygenase-1 (COX-1) reaction.	Quercetin	96-105	prostaglandin-endoperoxide synthase 1	Homo sapiens	163-168
20728021-0	2010	Quercetin up-regulates paraoxonase 1 gene expression via sterol regulatory element binding protein 2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in paraoxonase 1 promoter in HuH7 liver cells.	Quercetin	0-9	sterol regulatory element binding transcription factor 2	Homo sapiens	57-100
20728021-0	2010	Quercetin up-regulates paraoxonase 1 gene expression via sterol regulatory element binding protein 2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in paraoxonase 1 promoter in HuH7 liver cells.	Quercetin	0-9	paraoxonase 1	Homo sapiens	245-258
20547734-6	2010	In contrast, quercetin selectively modulated calcium signaling but with effects only on truncated GLP-1 peptides or exendin and not oxyntomodulin or full-length peptides.	Quercetin	13-22	glucagon	Homo sapiens	98-103
20728021-0	2010	Quercetin up-regulates paraoxonase 1 gene expression via sterol regulatory element binding protein 2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in paraoxonase 1 promoter in HuH7 liver cells.	Quercetin	0-9	MIR7-3 host gene	Homo sapiens	271-275
20728021-1	2010	We previously showed that quercetin expresses its antiatherogenic effects by up-regulating paraoxonase 1 (PON1) gene and high-density lipoprotein"s protective capacity against low-density lipoprotein oxidation.	Quercetin	26-35	paraoxonase 1	Homo sapiens	91-104
20728021-1	2010	We previously showed that quercetin expresses its antiatherogenic effects by up-regulating paraoxonase 1 (PON1) gene and high-density lipoprotein"s protective capacity against low-density lipoprotein oxidation.	Quercetin	26-35	paraoxonase 1	Homo sapiens	106-110
20728021-3	2010	Quercetin (20 micromol/L) treatment increased PON1 messenger RNA by 75% (P &lt; .02), with a concomitant 2-fold (P &lt; .05) increase in PON1 activity accompanied by 60% (P &lt; .01) increase in PON1 protein level.	Quercetin	0-9	paraoxonase 1	Homo sapiens	46-50
20728021-3	2010	Quercetin (20 micromol/L) treatment increased PON1 messenger RNA by 75% (P &lt; .02), with a concomitant 2-fold (P &lt; .05) increase in PON1 activity accompanied by 60% (P &lt; .01) increase in PON1 protein level.	Quercetin	0-9	paraoxonase 1	Homo sapiens	137-141
20728021-3	2010	Quercetin (20 micromol/L) treatment increased PON1 messenger RNA by 75% (P &lt; .02), with a concomitant 2-fold (P &lt; .05) increase in PON1 activity accompanied by 60% (P &lt; .01) increase in PON1 protein level.	Quercetin	0-9	paraoxonase 1	Homo sapiens	137-141
20728021-4	2010	There was parallel to the 1.5- to 2.0-fold increase (P &lt; .05) in mature SREBP2 in the cell nuclei that was verified by increased immunolocalization of the mature SREBP2 (65-kd species) in the nuclei of quercetin-treated cells by confocal microscopy.	Quercetin	205-214	sterol regulatory element binding transcription factor 2	Homo sapiens	75-81
20728021-5	2010	Evaluation of the binding of biotin-labeled sterol responsive element (SRE)-like element of the PON1 promoter to the nuclear extract from the 24-hour quercetin (20 micromol/L)-treated HuH7 cells by electrophoretic mobility shift assay revealed that the SREBP2 specifically binds to the SRE-like element that was abolished by prior incubation with anti-SREBP2 or significantly decreased by 200-fold molar excess of unlabeled SRE-like sequence.	Quercetin	150-159	paraoxonase 1	Homo sapiens	96-100
20728021-5	2010	Evaluation of the binding of biotin-labeled sterol responsive element (SRE)-like element of the PON1 promoter to the nuclear extract from the 24-hour quercetin (20 micromol/L)-treated HuH7 cells by electrophoretic mobility shift assay revealed that the SREBP2 specifically binds to the SRE-like element that was abolished by prior incubation with anti-SREBP2 or significantly decreased by 200-fold molar excess of unlabeled SRE-like sequence.	Quercetin	150-159	MIR7-3 host gene	Homo sapiens	184-188
20728021-6	2010	Based on these results, we conclude that quercetin exhibits its antiatherogenic property by eliciting the translocation of the mature SREBP2 from endoplasmic reticulum to the nucleus, where it binds to SRE-like sequence in the PON1 promoter and up-regulates PON1 gene transcription and PON1 activity.	Quercetin	41-50	sterol regulatory element binding transcription factor 2	Homo sapiens	134-140
20728021-6	2010	Based on these results, we conclude that quercetin exhibits its antiatherogenic property by eliciting the translocation of the mature SREBP2 from endoplasmic reticulum to the nucleus, where it binds to SRE-like sequence in the PON1 promoter and up-regulates PON1 gene transcription and PON1 activity.	Quercetin	41-50	paraoxonase 1	Homo sapiens	227-231
20728021-6	2010	Based on these results, we conclude that quercetin exhibits its antiatherogenic property by eliciting the translocation of the mature SREBP2 from endoplasmic reticulum to the nucleus, where it binds to SRE-like sequence in the PON1 promoter and up-regulates PON1 gene transcription and PON1 activity.	Quercetin	41-50	paraoxonase 1	Homo sapiens	258-262
20728021-6	2010	Based on these results, we conclude that quercetin exhibits its antiatherogenic property by eliciting the translocation of the mature SREBP2 from endoplasmic reticulum to the nucleus, where it binds to SRE-like sequence in the PON1 promoter and up-regulates PON1 gene transcription and PON1 activity.	Quercetin	41-50	paraoxonase 1	Homo sapiens	258-262
20681654-4	2010	Notably, quercetin increased cell cycle arrest in the G1 phase and up-regulated apoptosis-related proteins, such as AMPK, p53, and p21, within 48 h. Furthermore, in vivo experiments showed that quercetin treatment resulted in a significant reduction in tumor volume over 6 weeks, and apoptosis-related protein induction by quercetin was significantly higher in the 100 mg/kg treated group compared to the control group.	Quercetin	9-18	tumor protein p53	Homo sapiens	122-125
20600213-10	2010	Catechol-O-methyltransferase (COMT) activity was significantly downregulated in quercetin-exposed mammary tissue.	Quercetin	80-89	catechol-O-methyltransferase	Rattus norvegicus	0-28
20600213-10	2010	Catechol-O-methyltransferase (COMT) activity was significantly downregulated in quercetin-exposed mammary tissue.	Quercetin	80-89	catechol-O-methyltransferase	Rattus norvegicus	30-34
20600213-13	2010	Inhibition of COMT activity by quercetin may expose breast cells chronically to E(2) and catechol estrogens.	Quercetin	31-40	catechol-O-methyltransferase	Rattus norvegicus	14-18
20648016-2	2010	Here, we investigated the ability of quercetin to sensitise primary cells from chronic lymphocytic leukaemia (CLL) to death receptor (DR) agonists, recombinant TNF-related-apoptosis-inducing ligand (rTRAIL) and anti-CD95, and to fludarabine, a widely used chemotherapeutic drug against CLL.	Quercetin	37-46	Fas cell surface death receptor	Homo sapiens	216-220
20648016-5	2010	RESULTS: Quercetin significantly enhanced anti-CD95- and rTRAIL-induced cell death as shown by decreased cell viability, increased caspase-3 and -9 activities, and positivity to Annexin V.	Quercetin	9-18	Fas cell surface death receptor	Homo sapiens	47-51
20648016-5	2010	RESULTS: Quercetin significantly enhanced anti-CD95- and rTRAIL-induced cell death as shown by decreased cell viability, increased caspase-3 and -9 activities, and positivity to Annexin V.	Quercetin	9-18	caspase 3	Homo sapiens	131-147
20648016-5	2010	RESULTS: Quercetin significantly enhanced anti-CD95- and rTRAIL-induced cell death as shown by decreased cell viability, increased caspase-3 and -9 activities, and positivity to Annexin V.	Quercetin	9-18	annexin A5	Homo sapiens	178-187
20466049-10	2010	In Western blot assays of hippocampal tissue, we found that quercetin-treated groups showed decreased expression of phosphorylated Akt (pAkt), phosphorylated calcium-calmodulin kinase II (pCaMKII), and phosphorylated cyclic AMP response element-binding protein (pCREB).	Quercetin	60-69	thymoma viral proto-oncogene 1	Mus musculus	131-134
19958256-0	2010	The antioxidant quercetin inhibits cellular proliferation via HIF-1-dependent induction of p21WAF.	Quercetin	16-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-67
19958256-4	2010	It was shown that quercetin induced HIF-1alpha expression and HIF-1 activity under normoxia and hypoxia in human HepG2 hepatoma cells.	Quercetin	18-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-46
19958256-4	2010	It was shown that quercetin induced HIF-1alpha expression and HIF-1 activity under normoxia and hypoxia in human HepG2 hepatoma cells.	Quercetin	18-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-41
19958256-5	2010	By using actinomycin D and cycloheximide, we showed that quercetin acted post-transcriptionally by prolonging the HIF-1alpha protein half-life.	Quercetin	57-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-124
19958256-6	2010	Thereby quercetin interfered with the proline hydroxylation-dependent HIF-1alpha protein destabilization in the N-terminal HIF-1alpha transactivation domain.	Quercetin	8-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-80
19958256-6	2010	Thereby quercetin interfered with the proline hydroxylation-dependent HIF-1alpha protein destabilization in the N-terminal HIF-1alpha transactivation domain.	Quercetin	8-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
19958256-7	2010	Experiments with quercetin analogues revealed that a flavonol structure and the presence of hydroxyl groups at position 3" and 4" are a prerequisite for the HIF-1alpha stabilizing effects.	Quercetin	17-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-167
19958256-8	2010	Further, quercetin inhibited cell proliferation and induced expression of the cell cycle inhibitor p21WAF and knocking-down HIF-1alpha disrupted these effects.	Quercetin	9-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-134
20681654-4	2010	Notably, quercetin increased cell cycle arrest in the G1 phase and up-regulated apoptosis-related proteins, such as AMPK, p53, and p21, within 48 h. Furthermore, in vivo experiments showed that quercetin treatment resulted in a significant reduction in tumor volume over 6 weeks, and apoptosis-related protein induction by quercetin was significantly higher in the 100 mg/kg treated group compared to the control group.	Quercetin	9-18	H3 histone pseudogene 16	Homo sapiens	131-134
20681654-4	2010	Notably, quercetin increased cell cycle arrest in the G1 phase and up-regulated apoptosis-related proteins, such as AMPK, p53, and p21, within 48 h. Furthermore, in vivo experiments showed that quercetin treatment resulted in a significant reduction in tumor volume over 6 weeks, and apoptosis-related protein induction by quercetin was significantly higher in the 100 mg/kg treated group compared to the control group.	Quercetin	194-203	tumor protein p53	Homo sapiens	122-125
20681654-4	2010	Notably, quercetin increased cell cycle arrest in the G1 phase and up-regulated apoptosis-related proteins, such as AMPK, p53, and p21, within 48 h. Furthermore, in vivo experiments showed that quercetin treatment resulted in a significant reduction in tumor volume over 6 weeks, and apoptosis-related protein induction by quercetin was significantly higher in the 100 mg/kg treated group compared to the control group.	Quercetin	194-203	H3 histone pseudogene 16	Homo sapiens	131-134
20681654-4	2010	Notably, quercetin increased cell cycle arrest in the G1 phase and up-regulated apoptosis-related proteins, such as AMPK, p53, and p21, within 48 h. Furthermore, in vivo experiments showed that quercetin treatment resulted in a significant reduction in tumor volume over 6 weeks, and apoptosis-related protein induction by quercetin was significantly higher in the 100 mg/kg treated group compared to the control group.	Quercetin	194-203	tumor protein p53	Homo sapiens	122-125
20681654-4	2010	Notably, quercetin increased cell cycle arrest in the G1 phase and up-regulated apoptosis-related proteins, such as AMPK, p53, and p21, within 48 h. Furthermore, in vivo experiments showed that quercetin treatment resulted in a significant reduction in tumor volume over 6 weeks, and apoptosis-related protein induction by quercetin was significantly higher in the 100 mg/kg treated group compared to the control group.	Quercetin	194-203	H3 histone pseudogene 16	Homo sapiens	131-134
20681654-5	2010	All of these results indicate that quercetin induces apoptosis via AMPK activation and p53-dependent apoptotic cell death in HT-29 colon cancer cells and that it may be a potential chemopreventive or therapeutic agent against HT-29 colon cancer.	Quercetin	35-44	tumor protein p53	Homo sapiens	87-90
20417201-4	2010	Neuropathological evaluation by thionin staining showed that quercetin (4 ml/kg, 50mg/kg, intraperitoneal injection), an inhibitor of HSP 70, blocked the protective effect of LIP against delayed neuronal death that is normally induced by lethal brain ischemic insult, indicating that HSP 70 participates in the induction of brain ischemic tolerance by LIP.	Quercetin	61-70	heat shock protein family A (Hsp70) member 4	Homo sapiens	134-140
20803121-8	2010	Quercetin caused S phase arrest by decreasing the protein expression of CDK2, cyclins A and B while increasing the p53 and p57 proteins.	Quercetin	0-9	cyclin dependent kinase 2	Homo sapiens	72-76
20803121-8	2010	Quercetin caused S phase arrest by decreasing the protein expression of CDK2, cyclins A and B while increasing the p53 and p57 proteins.	Quercetin	0-9	cyclin A2	Homo sapiens	78-93
20803121-8	2010	Quercetin caused S phase arrest by decreasing the protein expression of CDK2, cyclins A and B while increasing the p53 and p57 proteins.	Quercetin	0-9	tumor protein p53	Homo sapiens	115-118
20803121-8	2010	Quercetin caused S phase arrest by decreasing the protein expression of CDK2, cyclins A and B while increasing the p53 and p57 proteins.	Quercetin	0-9	cyclin dependent kinase inhibitor 1C	Homo sapiens	123-126
20803121-9	2010	Following incubation with quercetin for 48 h, MCF-7 cells showed apoptotic cell death by the decreased levels of Bcl-2 protein and DeltaPsi(m) and increased activations of caspase-6, -8 and -9.	Quercetin	26-35	BCL2 apoptosis regulator	Homo sapiens	113-118
20803121-9	2010	Following incubation with quercetin for 48 h, MCF-7 cells showed apoptotic cell death by the decreased levels of Bcl-2 protein and DeltaPsi(m) and increased activations of caspase-6, -8 and -9.	Quercetin	26-35	caspase 6	Homo sapiens	172-192
20803121-10	2010	Moreover, quercetin increased the AIF protein released from mitochondria to nuclei and the GADD153 protein translocation from endoplasmic reticulum to the nuclei.	Quercetin	10-19	apoptosis inducing factor mitochondria associated 1	Homo sapiens	34-37
20803121-10	2010	Moreover, quercetin increased the AIF protein released from mitochondria to nuclei and the GADD153 protein translocation from endoplasmic reticulum to the nuclei.	Quercetin	10-19	DNA damage inducible transcript 3	Homo sapiens	91-98
20416132-10	2010	When comparing placebo and quercetin treatment, four genes showed significantly different expression changes (C1GALT1, O-glycan biosynthesis; GM2A, glycolipid catabolism; HDGF, cell proliferation; SERPINB9, apoptosis).	Quercetin	27-36	Core 1 Galactosyltransferase A	Drosophila melanogaster	110-117
20730955-0	2010	Inhibition mode of soybean lipoxygenase-1 by quercetin.	Quercetin	45-54	seed linoleate 13S-lipoxygenase-1	Glycine max	27-41
20730955-1	2010	Quercetin noncompetitively inhibited the peroxidation of linoleic acid catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, Type 1) with an IC(50) value of 4.8 microM (1.45 microg/ml).	Quercetin	0-9	seed linoleate 13S-lipoxygenase-1	Glycine max	92-106
20417201-4	2010	Neuropathological evaluation by thionin staining showed that quercetin (4 ml/kg, 50mg/kg, intraperitoneal injection), an inhibitor of HSP 70, blocked the protective effect of LIP against delayed neuronal death that is normally induced by lethal brain ischemic insult, indicating that HSP 70 participates in the induction of brain ischemic tolerance by LIP.	Quercetin	61-70	heat shock protein family A (Hsp70) member 4	Homo sapiens	284-290
20307882-0	2010	Impact of apolipoprotein E genotype and dietary quercetin on paraoxonase 1 status in apoE3 and apoE4 transgenic mice.	Quercetin	48-57	paraoxonase 1	Mus musculus	61-74
20599706-3	2010	Here, the affinity of daidzein and daidzein metabolites as well as of genistein, naringenin, and quercetin for human serum albumin (HSA) has been assessed in the absence and presence of oleate.	Quercetin	97-106	albumin	Homo sapiens	117-130
20386985-0	2010	Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin.	Quercetin	161-170	AKT serine/threonine kinase 1	Homo sapiens	19-22
20386985-0	2010	Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin.	Quercetin	161-170	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	23-32
20386985-0	2010	Activation of PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin.	Quercetin	161-170	nuclear factor kappa B subunit 1	Homo sapiens	33-42
20386985-3	2010	The result from MTT assay showed that quercetin decreased cell viability of both low metastatic cell line ACC-2 and high metastatic cell line ACC-M in a concentration- and time-dependent manner.	Quercetin	38-47	BCL2 related protein A1	Homo sapiens	106-111
20386985-5	2010	Our data also revealed that the apoptosis induced by quercetin treatment was through a mitochondria-dependent pathway which showed close correlation with the down-regulation of the PI3K/Akt/IKK-alpha/NF-kappaB pathway.	Quercetin	53-62	AKT serine/threonine kinase 1	Homo sapiens	186-189
20386985-5	2010	Our data also revealed that the apoptosis induced by quercetin treatment was through a mitochondria-dependent pathway which showed close correlation with the down-regulation of the PI3K/Akt/IKK-alpha/NF-kappaB pathway.	Quercetin	53-62	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	190-199
20386985-5	2010	Our data also revealed that the apoptosis induced by quercetin treatment was through a mitochondria-dependent pathway which showed close correlation with the down-regulation of the PI3K/Akt/IKK-alpha/NF-kappaB pathway.	Quercetin	53-62	nuclear factor kappa B subunit 1	Homo sapiens	200-209
20386985-6	2010	Most importantly, quercetin significantly prevented in vivo growth of ACC xenografts in nude mice, accompanied by induction of tumor cell apoptosis, suppression of NF-kappaB nuclear translocation, as well as down-regulation of Akt and IKK-alpha activation.	Quercetin	18-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	164-173
20386985-6	2010	Most importantly, quercetin significantly prevented in vivo growth of ACC xenografts in nude mice, accompanied by induction of tumor cell apoptosis, suppression of NF-kappaB nuclear translocation, as well as down-regulation of Akt and IKK-alpha activation.	Quercetin	18-27	thymoma viral proto-oncogene 1	Mus musculus	227-230
20386985-6	2010	Most importantly, quercetin significantly prevented in vivo growth of ACC xenografts in nude mice, accompanied by induction of tumor cell apoptosis, suppression of NF-kappaB nuclear translocation, as well as down-regulation of Akt and IKK-alpha activation.	Quercetin	18-27	conserved helix-loop-helix ubiquitous kinase	Mus musculus	235-244
20386985-9	2010	Taken together, the results from our study implicated that quercetin would be a promising chemotherapeutic agent against ACC through its function of down-regulating the PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway.	Quercetin	59-68	AKT serine/threonine kinase 1	Homo sapiens	174-177
20386985-9	2010	Taken together, the results from our study implicated that quercetin would be a promising chemotherapeutic agent against ACC through its function of down-regulating the PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway.	Quercetin	59-68	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	178-187
20386985-9	2010	Taken together, the results from our study implicated that quercetin would be a promising chemotherapeutic agent against ACC through its function of down-regulating the PI3K/Akt/IKK-alpha/NF-kappaB signaling pathway.	Quercetin	59-68	nuclear factor kappa B subunit 1	Homo sapiens	188-197
20307882-1	2010	OBJECTIVES: The aim of the present study was to determine hepatic paraoxonase 1 (PON1) status in response to apoE genotype and dietary quercetin supplementation in mice.	Quercetin	135-144	paraoxonase 1	Mus musculus	66-79
20307882-1	2010	OBJECTIVES: The aim of the present study was to determine hepatic paraoxonase 1 (PON1) status in response to apoE genotype and dietary quercetin supplementation in mice.	Quercetin	135-144	paraoxonase 1	Mus musculus	81-85
20307882-4	2010	Feeding quercetin-enriched diets induced hepatic PON1 gene expression with a tendency for greater induction in apoE3 as compared to apoE4 mice.	Quercetin	8-17	paraoxonase 1	Mus musculus	49-53
20551291-0	2010	Quercetin potentiates UVB-Induced c-Fos expression: implications for its use as a chemopreventive agent.	Quercetin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-39
20302682-4	2010	Quercetin alone attenuated the H2O2-mediated ERK1/2-Cx43 signalling pathway and consequently reversed H2O2-mediated inhibition of GJIC in WB-F344 cells.	Quercetin	0-9	gap junction protein, alpha 1	Rattus norvegicus	52-56
20302682-5	2010	A free radical-scavenging assay using 1,1-diphenyl-2-picrylhydrazyl showed that the scavenging activity of quercetin was higher than that of a synthetic antioxidant, butylated hydroxytoluene, per mol, suggesting that the chemopreventive effect of quercetin on H2O2-mediated inhibition of ERK1/2-Cx43 signalling and GJIC may be mediated through its free radical-scavenging activity.	Quercetin	107-116	mitogen activated protein kinase 3	Rattus norvegicus	288-294
20302682-5	2010	A free radical-scavenging assay using 1,1-diphenyl-2-picrylhydrazyl showed that the scavenging activity of quercetin was higher than that of a synthetic antioxidant, butylated hydroxytoluene, per mol, suggesting that the chemopreventive effect of quercetin on H2O2-mediated inhibition of ERK1/2-Cx43 signalling and GJIC may be mediated through its free radical-scavenging activity.	Quercetin	107-116	gap junction protein, alpha 1	Rattus norvegicus	295-299
20302682-4	2010	Quercetin alone attenuated the H2O2-mediated ERK1/2-Cx43 signalling pathway and consequently reversed H2O2-mediated inhibition of GJIC in WB-F344 cells.	Quercetin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	45-51
20447470-5	2010	Treatment with quercetin promoted lymphocyte proliferation and regulated Th1/Th2 cytokine imbalance.	Quercetin	15-24	negative elongation factor complex member C/D, Th1l	Mus musculus	73-76
20693966-7	2010	In resistant Jurkat/A4 cells, vepeside or quercetin treatment activates significantly less caspase-9 and -3 as compared with that in the parental cells.	Quercetin	42-51	caspase 9	Homo sapiens	91-107
20447470-5	2010	Treatment with quercetin promoted lymphocyte proliferation and regulated Th1/Th2 cytokine imbalance.	Quercetin	15-24	heart and neural crest derivatives expressed 2	Mus musculus	77-80
20445016-7	2010	These findings suggested that the protective effect of quercetin involved the inhibition of phosphorylated p38 MAP activity.	Quercetin	55-64	mitogen-activated protein kinase 1	Homo sapiens	107-110
20445016-5	2010	Pretreatment with quercetin (10 micromol/L; 30 minutes) prior to H(2)O(2) prevented the loss of ZO-1 and occludin.	Quercetin	18-27	tight junction protein 1	Homo sapiens	96-100
20445016-5	2010	Pretreatment with quercetin (10 micromol/L; 30 minutes) prior to H(2)O(2) prevented the loss of ZO-1 and occludin.	Quercetin	18-27	occludin	Homo sapiens	105-113
20083342-0	2010	Induction of apoptosis by quercetin is mediated through AMPKalpha1/ASK1/p38 pathway.	Quercetin	26-35	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	56-66
20445016-6	2010	In addition, the level of phosphorylated p38 MAPK, but not that of the phosphorylated ERK1/2, decreased in quercetin-pretreated group.	Quercetin	107-116	mitogen-activated protein kinase 1	Homo sapiens	41-44
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	93-98
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	132-137
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	138-141
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	211-214
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	Fas associated via death domain	Homo sapiens	216-220
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	caspase 3	Homo sapiens	222-231
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	caspase 9	Homo sapiens	236-245
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	307-316
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	318-323
20361964-6	2010	Quercetin treatment protected ARPE-19 cells from H(2)O(2)-induced oxidative injury, enhanced BCL-2 transcript levels, increased the BCL-2/BAX ratio, suppressed the transcription of pro-apoptotic factors such as BAX, FADD, CASPASE-3 and CASPASE-9, inhibited the transcription of inflammatory factors such as TNF-alpha, COX-2 and INOS, and decreased the levels of COX and NO in the culture medium.	Quercetin	0-9	nitric oxide synthase 2	Homo sapiens	328-332
20361964-13	2010	Although quercetin treatment could recover systemic anti-oxidative capacity, suppress the systemic expression of NO, COX and PGE-2, and decrease ocular A2E levels, it could not effectively suppress the transcripts of the ocular inflammatory factors Tnf-alpha, Cox-2 and Inos, or the pro-apoptotic factors Fas, FasL and Caspase-3 in DKO mice.	Quercetin	9-18	cytochrome c oxidase II, mitochondrial	Mus musculus	260-265
20361964-13	2010	Although quercetin treatment could recover systemic anti-oxidative capacity, suppress the systemic expression of NO, COX and PGE-2, and decrease ocular A2E levels, it could not effectively suppress the transcripts of the ocular inflammatory factors Tnf-alpha, Cox-2 and Inos, or the pro-apoptotic factors Fas, FasL and Caspase-3 in DKO mice.	Quercetin	9-18	nitric oxide synthase 2, inducible	Mus musculus	270-274
20361964-13	2010	Although quercetin treatment could recover systemic anti-oxidative capacity, suppress the systemic expression of NO, COX and PGE-2, and decrease ocular A2E levels, it could not effectively suppress the transcripts of the ocular inflammatory factors Tnf-alpha, Cox-2 and Inos, or the pro-apoptotic factors Fas, FasL and Caspase-3 in DKO mice.	Quercetin	9-18	Fas ligand (TNF superfamily, member 6)	Mus musculus	310-314
20361964-13	2010	Although quercetin treatment could recover systemic anti-oxidative capacity, suppress the systemic expression of NO, COX and PGE-2, and decrease ocular A2E levels, it could not effectively suppress the transcripts of the ocular inflammatory factors Tnf-alpha, Cox-2 and Inos, or the pro-apoptotic factors Fas, FasL and Caspase-3 in DKO mice.	Quercetin	9-18	caspase 3	Mus musculus	319-328
20083342-0	2010	Induction of apoptosis by quercetin is mediated through AMPKalpha1/ASK1/p38 pathway.	Quercetin	26-35	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	67-71
20083342-0	2010	Induction of apoptosis by quercetin is mediated through AMPKalpha1/ASK1/p38 pathway.	Quercetin	26-35	mitogen-activated protein kinase 14	Homo sapiens	72-75
20083342-2	2010	In this study, we investigated the regulatory mechanism of quercetin-induced apoptosis through apoptosis signal-regulating kinase (ASK)-1 and mitogen-activated protein kinase pathways.	Quercetin	59-68	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	95-137
20083342-3	2010	Our results showed that quercetin increased apoptotic cell death through reactive oxygen species (ROS) generation and was responsible for ASK1 activation.	Quercetin	24-33	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	138-142
20083342-5	2010	Interestingly, AMP-activated protein kinase (AMPK) seemed to be a critical controller of quercetin-regulated ASK1/p38 activation.	Quercetin	89-98	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	45-49
20083342-5	2010	Interestingly, AMP-activated protein kinase (AMPK) seemed to be a critical controller of quercetin-regulated ASK1/p38 activation.	Quercetin	89-98	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	109-113
20083342-5	2010	Interestingly, AMP-activated protein kinase (AMPK) seemed to be a critical controller of quercetin-regulated ASK1/p38 activation.	Quercetin	89-98	mitogen-activated protein kinase 14	Homo sapiens	114-117
20083342-7	2010	Thus, we suggested that quercetin-exerted apoptotic effects involve ROS/AMPKalpha1/ASK1/p38 signaling pathway, and AMPKalpha1 is a necessary element for apoptotic event induced by ASK1.	Quercetin	24-33	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	72-82
20083342-7	2010	Thus, we suggested that quercetin-exerted apoptotic effects involve ROS/AMPKalpha1/ASK1/p38 signaling pathway, and AMPKalpha1 is a necessary element for apoptotic event induced by ASK1.	Quercetin	24-33	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	83-87
20083342-7	2010	Thus, we suggested that quercetin-exerted apoptotic effects involve ROS/AMPKalpha1/ASK1/p38 signaling pathway, and AMPKalpha1 is a necessary element for apoptotic event induced by ASK1.	Quercetin	24-33	mitogen-activated protein kinase 14	Homo sapiens	88-91
20083342-7	2010	Thus, we suggested that quercetin-exerted apoptotic effects involve ROS/AMPKalpha1/ASK1/p38 signaling pathway, and AMPKalpha1 is a necessary element for apoptotic event induced by ASK1.	Quercetin	24-33	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	180-184
20417174-2	2010	Quercetin (Qt) has anti-inflammatory properties through its ability to inhibits nitric oxide production and iNOS expression in different cellular types.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	108-112
20534444-6	2010	RT-PCR and biochemical studies suggested that deletion of Bm-UGT10286 (UGT) is responsible for Gb and Bm-UGT10286 is virtually the sole source of UGT activity toward the 5-O position of quercetin.	Quercetin	186-195	UDP-glucosyltransferase	Bombyx mori	58-69
20534444-6	2010	RT-PCR and biochemical studies suggested that deletion of Bm-UGT10286 (UGT) is responsible for Gb and Bm-UGT10286 is virtually the sole source of UGT activity toward the 5-O position of quercetin.	Quercetin	186-195	UDP-glucosyltransferase	Bombyx mori	61-64
20534444-6	2010	RT-PCR and biochemical studies suggested that deletion of Bm-UGT10286 (UGT) is responsible for Gb and Bm-UGT10286 is virtually the sole source of UGT activity toward the 5-O position of quercetin.	Quercetin	186-195	UDP-glucosyltransferase	Bombyx mori	71-74
20417174-2	2010	Quercetin (Qt) has anti-inflammatory properties through its ability to inhibits nitric oxide production and iNOS expression in different cellular types.	Quercetin	11-13	nitric oxide synthase 2, inducible	Mus musculus	108-112
20122975-13	2010	Application of geldanamycin, radicicol, quercetin or KNK 437 in combination with aldosterone blocks development of tubules by disturbing the contact between MR and heat shock proteins 90 and 70.	Quercetin	40-49	nuclear receptor subfamily 3 group C member 2	Homo sapiens	157-159
20483746-8	2010	Blockage of LPS-induced ERK, JNK, Akt, and NF-kappaB activation contributed to the inhibitory effect of quercetin on DCs.	Quercetin	104-113	mitogen-activated protein kinase 1	Mus musculus	24-27
20483746-8	2010	Blockage of LPS-induced ERK, JNK, Akt, and NF-kappaB activation contributed to the inhibitory effect of quercetin on DCs.	Quercetin	104-113	mitogen-activated protein kinase 8	Mus musculus	29-32
20483746-8	2010	Blockage of LPS-induced ERK, JNK, Akt, and NF-kappaB activation contributed to the inhibitory effect of quercetin on DCs.	Quercetin	104-113	thymoma viral proto-oncogene 1	Mus musculus	34-37
20540768-4	2010	We have previously demonstrated that the bioflavonoid quercetin (Qct) promoted a p53-mediated response and sensitized melanoma to DTIC.	Quercetin	54-63	tumor protein p53	Homo sapiens	81-84
20371363-2	2010	The theme of our study was to evaluate the therapeutic efficacy of liposomal and nanocapsulated herbal polyphenolic antioxidant quercetin (QC) in combating arsenic induced hepatic oxidative stress, fibrosis associated upregulation of its gene expression and plasma TGF beta (transforming growth factor beta) in rat model.	Quercetin	128-137	transforming growth factor, beta 1	Rattus norvegicus	265-273
20548785-0	2010	Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmission.	Quercetin	0-9	DnaJ heat shock protein family (Hsp40) member C5	Mus musculus	18-41
20548785-8	2010	Quercetin"s action on CSPalpha is concentration dependent and does not promote dimerization of other synaptic proteins or other J protein family members and reduces the assembly of CSPalpha:Hsc70 units (70kDa heat shock cognate protein).	Quercetin	0-9	heat shock protein 8	Mus musculus	190-195
20153296-4	2010	We found that apigenin, luteolin, fisetin and quercetin inhibited hypoxia-induced VEGF expression in the low micromolar range.	Quercetin	46-55	vascular endothelial growth factor A	Homo sapiens	82-86
20153296-6	2010	Interestingly, only a group of VEGF inhibitors, including apigenin, flavone and 4",7-dihydroxiflavone, reduced the expression of HIF-1alpha under these conditions, whereas others, such as fisetin, luteolin, galangin or quercetin, induced HIF-1alpha expression while reducing those of VEGF.	Quercetin	219-228	vascular endothelial growth factor A	Homo sapiens	31-35
20153296-6	2010	Interestingly, only a group of VEGF inhibitors, including apigenin, flavone and 4",7-dihydroxiflavone, reduced the expression of HIF-1alpha under these conditions, whereas others, such as fisetin, luteolin, galangin or quercetin, induced HIF-1alpha expression while reducing those of VEGF.	Quercetin	219-228	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
19902529-1	2010	The interaction between quercetin, a popular antioxidant flavonoid, and human serum albumin (HSA) is investigated and characterized by means of induced circular dichroism and saturation transfer difference NMR.	Quercetin	24-33	albumin	Homo sapiens	78-91
20484173-5	2010	Intake of flavonols, especially of isorhamnetin, kaempferol, and quercetin, was inversely associated with serum IL-6 concentrations (highest versus lowest flavonol intake quartile, 1.80 versus 2.20 pg/mL) and high-risk (OR, 0.51; 95% CI, 0.26-0.98) and advanced adenoma recurrence (OR, 0.17; 95% CI, 0.06-0.50).	Quercetin	65-74	interleukin 6	Homo sapiens	112-116
20346546-0	2010	A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.	Quercetin	97-106	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	152-194
20346546-6	2010	Quercetin, the most active compound, was docked into the crystal structure of 11beta-HSD1.	Quercetin	0-9	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	78-89
20577025-9	2010	Furthermore, in our experiments decreased secretion of matrix metalloproteinases (MMP-2 and MMP-9) was observed after a 72 h treatment with quercetin.	Quercetin	140-149	matrix metallopeptidase 2	Homo sapiens	82-87
20381572-4	2010	In the catechin plus chlorpyrifos- and quercetin plus chlorpyrifos-treated groups, there were statistically significant increases in CAT and SOD activities, while no statistically significant changes were observed in MDA, GST and GPx activities relative to the control.	Quercetin	39-48	catalase	Rattus norvegicus	133-136
20381572-5	2010	Compared to the chlorpyrifos-treated group, however, the catechin plus chlorpyrifos- and quercetin plus chlorpyrifos-treated groups showed significantly increased GST and GPx activity, while the activity of MDA, SOD and CAT was significantly decreased.	Quercetin	89-98	hematopoietic prostaglandin D synthase	Rattus norvegicus	163-166
20381572-5	2010	Compared to the chlorpyrifos-treated group, however, the catechin plus chlorpyrifos- and quercetin plus chlorpyrifos-treated groups showed significantly increased GST and GPx activity, while the activity of MDA, SOD and CAT was significantly decreased.	Quercetin	89-98	catalase	Rattus norvegicus	220-223
20012900-13	2010	We have shown that quercetin also up regulates PON1 gene in rats and in human liver cells.	Quercetin	19-28	paraoxonase 1	Rattus norvegicus	47-51
20012900-14	2010	The action of quercetin seems to be mediated via the active form of the nuclear lipogenic transcription factor, sterol-regulatory element-binding protein 2 (SREBP2) that is translocated from endoplasmic reticulum to the nucleus.	Quercetin	14-23	sterol regulatory element binding transcription factor 2	Homo sapiens	112-155
20012900-14	2010	The action of quercetin seems to be mediated via the active form of the nuclear lipogenic transcription factor, sterol-regulatory element-binding protein 2 (SREBP2) that is translocated from endoplasmic reticulum to the nucleus.	Quercetin	14-23	sterol regulatory element binding transcription factor 2	Homo sapiens	157-163
20012900-16	2010	We conclude that both moderate ethanol and quercetin, the two major components of red wine, exhibit cardioprotective properties via the up-regulation of the antiatherogenic gene PON1.	Quercetin	43-52	paraoxonase 1	Homo sapiens	178-182
20524817-7	2010	Similarly, the flavonoid quercetin abolished the influence of iron on the activity of TrxR.	Quercetin	25-34	peroxiredoxin 5	Rattus norvegicus	86-90
20577025-9	2010	Furthermore, in our experiments decreased secretion of matrix metalloproteinases (MMP-2 and MMP-9) was observed after a 72 h treatment with quercetin.	Quercetin	140-149	matrix metallopeptidase 9	Homo sapiens	92-97
20184953-0	2010	Quercetin is a substrate for the transmembrane oxidoreductase Dcytb.	Quercetin	0-9	cytochrome b reductase 1	Homo sapiens	62-67
20148354-0	2010	Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells.	Quercetin	49-58	androgen receptor	Homo sapiens	19-36
20148354-0	2010	Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells.	Quercetin	49-58	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-109
20148354-0	2010	Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells.	Quercetin	49-58	androgen receptor	Homo sapiens	119-136
20148354-1	2010	We have previously reported that the increase in c-Jun expression induced by quercetin inhibited androgen receptor (AR) transactivation, and Sp1 was involved in quercetin-mediated downregulation of AR activity.	Quercetin	77-86	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
20148354-1	2010	We have previously reported that the increase in c-Jun expression induced by quercetin inhibited androgen receptor (AR) transactivation, and Sp1 was involved in quercetin-mediated downregulation of AR activity.	Quercetin	77-86	androgen receptor	Homo sapiens	97-114
20148354-1	2010	We have previously reported that the increase in c-Jun expression induced by quercetin inhibited androgen receptor (AR) transactivation, and Sp1 was involved in quercetin-mediated downregulation of AR activity.	Quercetin	77-86	androgen receptor	Homo sapiens	116-118
20148354-1	2010	We have previously reported that the increase in c-Jun expression induced by quercetin inhibited androgen receptor (AR) transactivation, and Sp1 was involved in quercetin-mediated downregulation of AR activity.	Quercetin	161-170	androgen receptor	Homo sapiens	198-200
20148354-4	2010	The physical associations of c-Jun, Sp1, and AR induced by quercetin were further demonstrated by co-immunoprecipitation experiments.	Quercetin	59-68	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-34
20148354-4	2010	The physical associations of c-Jun, Sp1, and AR induced by quercetin were further demonstrated by co-immunoprecipitation experiments.	Quercetin	59-68	androgen receptor	Homo sapiens	45-47
20148354-5	2010	In addition, quercetin-mediated repression of AR expression and activity was partially reversed by blocking of JNK signaling pathway.	Quercetin	13-22	androgen receptor	Homo sapiens	46-48
20148354-6	2010	These results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells.	Quercetin	132-141	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-34
20148354-6	2010	These results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells.	Quercetin	132-141	androgen receptor	Homo sapiens	86-88
20148354-6	2010	These results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells.	Quercetin	204-213	androgen receptor	Homo sapiens	86-88
20148354-6	2010	These results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells.	Quercetin	204-213	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	164-169
20148354-6	2010	These results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells.	Quercetin	204-213	androgen receptor	Homo sapiens	174-176
20148354-6	2010	These results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells.	Quercetin	204-213	androgen receptor	Homo sapiens	174-176
20184953-3	2010	In Dcytb(+) cells there is a saturable increase in extracellular Fe(III) reduction in response to increasing intracellular quercetin concentrations (K(m)=6.53+/-1.57 microM), in addition to a small linear response, whereas in Dcytb-null cells there is only a small linear increase in extracellular Fe(III) reduction.	Quercetin	123-132	cytochrome b reductase 1	Homo sapiens	3-8
20184953-3	2010	In Dcytb(+) cells there is a saturable increase in extracellular Fe(III) reduction in response to increasing intracellular quercetin concentrations (K(m)=6.53+/-1.57 microM), in addition to a small linear response, whereas in Dcytb-null cells there is only a small linear increase in extracellular Fe(III) reduction.	Quercetin	123-132	cytochrome b reductase 1	Homo sapiens	226-231
20434432-7	2010	However, with the presence of catalase, the protective effects of quercetin on pathogen resistance to virulent Pst disappeared in Arabidopsis, suggesting that H(2)O(2) may play a key role in plant defense responses.	Quercetin	66-75	catalase KatB	Pseudomonas syringae pv. tomato str. DC3000	30-38
20434432-9	2010	Furthermore, strong defense responses have been observed in quercetin-pretreated Arabidopsis mutant jar1, ein2, and abi1-2 under Pst challenge, whereas no protective effect has been observed in quercetin-pretreated Arabidopsis mutant NahG and npr1.	Quercetin	60-69	Protein phosphatase 2C family protein	Arabidopsis thaliana	116-120
20434432-9	2010	Furthermore, strong defense responses have been observed in quercetin-pretreated Arabidopsis mutant jar1, ein2, and abi1-2 under Pst challenge, whereas no protective effect has been observed in quercetin-pretreated Arabidopsis mutant NahG and npr1.	Quercetin	60-69	regulatory protein (NPR1)	Arabidopsis thaliana	243-247
20434432-10	2010	These findings indicate that quercetin induces the resistance to Pst in Arabidopsis via H(2)O(2) burst and involvement of SA and NPR1.	Quercetin	29-38	regulatory protein (NPR1)	Arabidopsis thaliana	129-133
19628228-8	2010	Quercetin partially attenuated glutamine induced HSP72 expression and blocked the protective response of glutamine.	Quercetin	0-9	heat shock protein 1A	Mus musculus	49-54
20184953-2	2010	We have investigated the capacity of the flavonoid quercetin to act as an electron donor for Dcytb in a manner similar to that of ascorbate by observing the reduction of extracellular Fe(III) to Fe(II) in either Madin-Darby canine kidney (MDCK) cells overexpressing Dcytb (Dcytb(+)) or Dcytb-null MDCK cells.	Quercetin	51-60	cytochrome b reductase 1	Homo sapiens	93-98
20377179-0	2010	Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells.	Quercetin	21-30	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	56-61
20377179-4	2010	The possible inhibitory effect of quercetin, a naturally occurring dietary flavonol, on arsenite-induced COX-2 expression and PGE(2) production was investigated.	Quercetin	34-43	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	105-110
20377179-10	2010	These results suggest that quercetin suppresses arsenite-induced COX-2 expression mainly by blocking the activation of the PI3K signaling pathway, which may contribute to its chemopreventive potential.	Quercetin	27-36	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	65-70
20377179-5	2010	Pretreatment with quercetin resulted in the reduction of arsenite-induced expression of COX-2 and production of PGE(2).	Quercetin	18-27	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	88-93
20377179-6	2010	The arsenite-induced phosphorylation of Akt, p70S6K, and extracellular signal-regulated protein kinases (ERKs), but not p38, was inhibited by quercetin treatment.	Quercetin	142-151	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
20377179-6	2010	The arsenite-induced phosphorylation of Akt, p70S6K, and extracellular signal-regulated protein kinases (ERKs), but not p38, was inhibited by quercetin treatment.	Quercetin	142-151	ribosomal protein S6 kinase B1	Rattus norvegicus	45-51
20377179-7	2010	An ex vivo kinase assay revealed that quercetin suppressed arsenite-induced phosphoinositide 3-kinase (PI3K) activity upstream of Akt in RLE cell lysates.	Quercetin	38-47	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	76-101
20377179-7	2010	An ex vivo kinase assay revealed that quercetin suppressed arsenite-induced phosphoinositide 3-kinase (PI3K) activity upstream of Akt in RLE cell lysates.	Quercetin	38-47	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
20386467-4	2010	The results of this study showed that quercetin significantly induced the expression of several NKG2D ligands including major histocompatibility complex class I-related chain B, UL16-binding protein 1, and UL16-binding protein 2 in K562, SNU1, and SNU-C4 cells.	Quercetin	38-47	killer cell lectin like receptor K1	Homo sapiens	96-101
20438634-6	2010	Interestingly, although withaferin A and quercetin treatments both decrease intracellular protein levels of Bcl2, Bim and P-Bad, only withaferin A decreases protein levels of cytoskeletal tubulin, concomitantly with potent PARP cleavage, caspase 3 activation and apoptosis, at least in part via a direct thiol oxidation mechanism.	Quercetin	41-50	collagen type XI alpha 2 chain	Homo sapiens	223-227
20438634-6	2010	Interestingly, although withaferin A and quercetin treatments both decrease intracellular protein levels of Bcl2, Bim and P-Bad, only withaferin A decreases protein levels of cytoskeletal tubulin, concomitantly with potent PARP cleavage, caspase 3 activation and apoptosis, at least in part via a direct thiol oxidation mechanism.	Quercetin	41-50	caspase 3	Homo sapiens	238-247
20096260-7	2010	Aspirin, quercetin, and simvastatin are compounds reported to increase PON1 expression.	Quercetin	9-18	paraoxonase 1	Homo sapiens	71-75
20533396-0	2010	Quercetin accumulation by chronic administration causes the caspase-3 activation in liver and brain of mice.	Quercetin	0-9	caspase 3	Mus musculus	60-69
20533396-6	2010	Nevertheless, quercetin induced apoptosis in both the liver and brain, as evidenced by increased caspase-3 expression and activity.	Quercetin	14-23	caspase 3	Mus musculus	97-106
20386467-0	2010	Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70.	Quercetin	0-9	killer cell lectin like receptor K1	Homo sapiens	96-101
20386467-0	2010	Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	129-134
20438634-5	2010	RESULTS: Although the natural withanolide withaferin A and polyphenol quercetin, show comparable inhibition of NFkappaB target genes (involved in inflammation, angiogenesis, cell cycle, metastasis, anti-apoptosis and multidrug resistance) in doxorubicin-sensitive K562 and -resistant K562/Adr cells, only withaferin A can overcome attenuated caspase activation and apoptosis in K562/Adr cells, whereas quercetin-dependent caspase activation and apoptosis is delayed only.	Quercetin	70-79	nuclear factor kappa B subunit 1	Homo sapiens	111-119
20438634-6	2010	Interestingly, although withaferin A and quercetin treatments both decrease intracellular protein levels of Bcl2, Bim and P-Bad, only withaferin A decreases protein levels of cytoskeletal tubulin, concomitantly with potent PARP cleavage, caspase 3 activation and apoptosis, at least in part via a direct thiol oxidation mechanism.	Quercetin	41-50	BCL2 apoptosis regulator	Homo sapiens	108-112
20438634-6	2010	Interestingly, although withaferin A and quercetin treatments both decrease intracellular protein levels of Bcl2, Bim and P-Bad, only withaferin A decreases protein levels of cytoskeletal tubulin, concomitantly with potent PARP cleavage, caspase 3 activation and apoptosis, at least in part via a direct thiol oxidation mechanism.	Quercetin	41-50	BCL2 like 11	Homo sapiens	114-117
20021702-4	2010	Resveratrol and quercetin (0.1-1 microm) increased eNOS and VEGF mRNA expression particularly in the absence of H2O2 (50 microm) and decreased H2O2-induced ET-1 mRNA expression (P &lt; 0.001 for polyphenol x H2O2 interactions).	Quercetin	16-25	nitric oxide synthase 3	Homo sapiens	51-55
20021702-4	2010	Resveratrol and quercetin (0.1-1 microm) increased eNOS and VEGF mRNA expression particularly in the absence of H2O2 (50 microm) and decreased H2O2-induced ET-1 mRNA expression (P &lt; 0.001 for polyphenol x H2O2 interactions).	Quercetin	16-25	vascular endothelial growth factor A	Homo sapiens	60-64
20021702-4	2010	Resveratrol and quercetin (0.1-1 microm) increased eNOS and VEGF mRNA expression particularly in the absence of H2O2 (50 microm) and decreased H2O2-induced ET-1 mRNA expression (P &lt; 0.001 for polyphenol x H2O2 interactions).	Quercetin	16-25	endothelin 1	Homo sapiens	156-160
20486938-2	2010	Ellagic acid, gallic acid, ferulic acid, caffeic acid, quercetin, p-coumaric acid, p-hydroxybenzoic acid, and syringic acid showed K(I) values in the range of 99-1061 microm for hCA I and of 105-758 microm against hCA II, respectively.	Quercetin	55-64	HCA1	Homo sapiens	178-181
20486938-2	2010	Ellagic acid, gallic acid, ferulic acid, caffeic acid, quercetin, p-coumaric acid, p-hydroxybenzoic acid, and syringic acid showed K(I) values in the range of 99-1061 microm for hCA I and of 105-758 microm against hCA II, respectively.	Quercetin	55-64	carbonic anhydrase 2	Homo sapiens	214-220
20486938-3	2010	Quercetin (for hCA I), p-coumaric acid (for hCA II), and gallic acid (for hCA II) exhibited competitive inhibitory effects with 4-nitrophenyl acetate as substrate.	Quercetin	0-9	carbonic anhydrase 1	Homo sapiens	15-20
20486938-3	2010	Quercetin (for hCA I), p-coumaric acid (for hCA II), and gallic acid (for hCA II) exhibited competitive inhibitory effects with 4-nitrophenyl acetate as substrate.	Quercetin	0-9	carbonic anhydrase 2	Homo sapiens	44-50
20486938-3	2010	Quercetin (for hCA I), p-coumaric acid (for hCA II), and gallic acid (for hCA II) exhibited competitive inhibitory effects with 4-nitrophenyl acetate as substrate.	Quercetin	0-9	carbonic anhydrase 2	Homo sapiens	74-80
20082303-0	2010	Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	45-49
20082303-0	2010	Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	58-63
20082303-0	2010	Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation.	Quercetin	0-9	epidermal growth factor receptor	Homo sapiens	68-72
20082303-2	2010	In this study, we found that quercetin increased the phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) and suppressed the viability of HeLa cells.	Quercetin	29-38	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	72-100
20082303-2	2010	In this study, we found that quercetin increased the phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) and suppressed the viability of HeLa cells.	Quercetin	29-38	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	102-106
20082303-3	2010	AICAR, an AMPK activator, and quercetin down-regulated heat shock protein (HSP)70 and increased the activity of the pro-apoptotic effector, caspase 3.	Quercetin	30-39	caspase 3	Homo sapiens	140-149
20082303-4	2010	Knock-down of AMPK blocked quercetin-mediated HSP70 down-regulation.	Quercetin	27-36	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	14-18
20082303-4	2010	Knock-down of AMPK blocked quercetin-mediated HSP70 down-regulation.	Quercetin	27-36	heat shock protein family A (Hsp70) member 4	Homo sapiens	46-51
20082303-5	2010	Moreover, knock-down of HSP70 enhanced quercetin-mediated caspase 3 activation.	Quercetin	39-48	heat shock protein family A (Hsp70) member 4	Homo sapiens	24-29
20082303-5	2010	Moreover, knock-down of HSP70 enhanced quercetin-mediated caspase 3 activation.	Quercetin	39-48	caspase 3	Homo sapiens	58-67
20082303-6	2010	Furthermore, quercetin sustained epidermal growth factor receptor (EGFR) activation by suppressing the phosphatases, PP2a and SHP-2.	Quercetin	13-22	epidermal growth factor receptor	Homo sapiens	33-65
20082303-6	2010	Furthermore, quercetin sustained epidermal growth factor receptor (EGFR) activation by suppressing the phosphatases, PP2a and SHP-2.	Quercetin	13-22	epidermal growth factor receptor	Homo sapiens	67-71
20082303-6	2010	Furthermore, quercetin sustained epidermal growth factor receptor (EGFR) activation by suppressing the phosphatases, PP2a and SHP-2.	Quercetin	13-22	protein phosphatase 2 phosphatase activator	Homo sapiens	117-121
20082303-6	2010	Furthermore, quercetin sustained epidermal growth factor receptor (EGFR) activation by suppressing the phosphatases, PP2a and SHP-2.	Quercetin	13-22	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	126-131
20082303-7	2010	Finally, quercetin increased the interaction between EGFR and Cbl, and also induced the tyrosine phosphorylation of Cbl.	Quercetin	9-18	epidermal growth factor receptor	Homo sapiens	53-57
20082303-7	2010	Finally, quercetin increased the interaction between EGFR and Cbl, and also induced the tyrosine phosphorylation of Cbl.	Quercetin	9-18	Cbl proto-oncogene	Homo sapiens	62-65
20082303-7	2010	Finally, quercetin increased the interaction between EGFR and Cbl, and also induced the tyrosine phosphorylation of Cbl.	Quercetin	9-18	Cbl proto-oncogene	Homo sapiens	116-119
20082303-8	2010	Together, these results suggest that quercetin may have anti-tumor effects on HeLa cells via AMPK-induced HSP70 and down-regulation of EGFR.	Quercetin	37-46	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	93-97
20082303-8	2010	Together, these results suggest that quercetin may have anti-tumor effects on HeLa cells via AMPK-induced HSP70 and down-regulation of EGFR.	Quercetin	37-46	heat shock protein family A (Hsp70) member 4	Homo sapiens	106-111
20082303-8	2010	Together, these results suggest that quercetin may have anti-tumor effects on HeLa cells via AMPK-induced HSP70 and down-regulation of EGFR.	Quercetin	37-46	epidermal growth factor receptor	Homo sapiens	135-139
20386467-3	2010	In this study, we investigated whether quercetin which has inhibitory activities against heat-shock factor, protein kinase C, nuclear factor-kappaB, and phosphatidyl inositol 3-kinase, can modulate the expression of NKG2D ligands and suppress the HSPs in tumor cells.	Quercetin	39-48	killer cell lectin like receptor K1	Homo sapiens	216-221
19911203-2	2010	In this work, we docked arachidonic acid and two of its competitive inhibitors, flavonoids baicalein and quercetin, into the binding pockets of human 12- and 15-lipoxygenase.	Quercetin	105-114	arachidonate 15-lipoxygenase	Homo sapiens	150-173
20054339-0	2010	Tannic acid and quercetin display a therapeutic effect in atopic dermatitis via suppression of angiogenesis and TARC expression in Nc/Nga mice.	Quercetin	16-25	chemokine (C-C motif) ligand 17	Mus musculus	112-116
20386467-4	2010	The results of this study showed that quercetin significantly induced the expression of several NKG2D ligands including major histocompatibility complex class I-related chain B, UL16-binding protein 1, and UL16-binding protein 2 in K562, SNU1, and SNU-C4 cells.	Quercetin	38-47	UL16 binding protein 1	Homo sapiens	178-200
20054339-0	2010	Tannic acid and quercetin display a therapeutic effect in atopic dermatitis via suppression of angiogenesis and TARC expression in Nc/Nga mice.	Quercetin	16-25	reticulon 4	Mus musculus	134-137
20386467-4	2010	The results of this study showed that quercetin significantly induced the expression of several NKG2D ligands including major histocompatibility complex class I-related chain B, UL16-binding protein 1, and UL16-binding protein 2 in K562, SNU1, and SNU-C4 cells.	Quercetin	38-47	UL16 binding protein 2	Homo sapiens	206-228
20386467-5	2010	The quercetin-treated K562, SNU1, and SNU-C4 cells showed an enhanced susceptibility to NK-92 cells through induction of NKG2D ligands.	Quercetin	4-13	killer cell lectin like receptor K1	Homo sapiens	121-126
20386467-7	2010	The findings of this study suggest that the induced NKG2D ligands with the decrease of HSP70 protein by quercetin may provide an attractive strategy to improve the effectiveness of NK cell-based cancer immunotherapy.	Quercetin	104-113	killer cell lectin like receptor K1	Homo sapiens	52-57
20386467-7	2010	The findings of this study suggest that the induced NKG2D ligands with the decrease of HSP70 protein by quercetin may provide an attractive strategy to improve the effectiveness of NK cell-based cancer immunotherapy.	Quercetin	104-113	heat shock protein family A (Hsp70) member 4	Homo sapiens	87-92
19961921-14	2010	Pretreatment with Q was found to protect against the decrease in SOD activity induced by beta-cyfluthrin.	Quercetin	18-19	superoxide dismutase 1	Homo sapiens	65-68
20417606-2	2010	We have discovered that the flavonol quercetin activates yeast IRE1"s RNase and potentiates activation by ADP, a natural activating ligand that engages the IRE1 nucleotide-binding cleft.	Quercetin	37-46	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	63-67
20417606-2	2010	We have discovered that the flavonol quercetin activates yeast IRE1"s RNase and potentiates activation by ADP, a natural activating ligand that engages the IRE1 nucleotide-binding cleft.	Quercetin	37-46	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	156-160
20417606-3	2010	Enzyme kinetics and the structure of a cocrystal of IRE1 complexed with ADP and quercetin reveal engagement by quercetin of an unanticipated ligand-binding pocket at the dimer interface of IRE1"s kinase extension nuclease (KEN) domain.	Quercetin	80-89	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	52-56
20417606-3	2010	Enzyme kinetics and the structure of a cocrystal of IRE1 complexed with ADP and quercetin reveal engagement by quercetin of an unanticipated ligand-binding pocket at the dimer interface of IRE1"s kinase extension nuclease (KEN) domain.	Quercetin	80-89	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	189-193
20417606-3	2010	Enzyme kinetics and the structure of a cocrystal of IRE1 complexed with ADP and quercetin reveal engagement by quercetin of an unanticipated ligand-binding pocket at the dimer interface of IRE1"s kinase extension nuclease (KEN) domain.	Quercetin	111-120	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	52-56
20417606-3	2010	Enzyme kinetics and the structure of a cocrystal of IRE1 complexed with ADP and quercetin reveal engagement by quercetin of an unanticipated ligand-binding pocket at the dimer interface of IRE1"s kinase extension nuclease (KEN) domain.	Quercetin	111-120	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	189-193
20110806-0	2010	Simultaneous liposomal delivery of quercetin and vincristine for enhanced estrogen-receptor-negative breast cancer treatment.	Quercetin	35-44	estrogen receptor 1	Homo sapiens	74-91
20059741-3	2010	By homology with an Arabidopsis flavonol synthase (AtFLS1), we cloned a maize gene encoding a protein (ZmFLS1) capable of converting the dihydrokaempferol (DHK) and dihydroquercetin (DHQ) dihydroflavonols to the corresponding flavonols, kaempferol (K) and quercetin (Q).	Quercetin	172-181	flavonol synthase 1	Arabidopsis thaliana	51-57
19423323-4	2010	Quercetin administration to rats significantly suppressed WIR stress-induced increase of plasma corticosterone and adrenocorticotropic hormone levels as well as the mRNA expression of corticotropin-releasing factor (CRF) in the hypothalamic region.	Quercetin	0-9	corticotropin releasing hormone	Rattus norvegicus	184-214
19423323-5	2010	In addition, quercetin modulated the DNA binding activities of glucocorticoid receptor and phosphorylated cyclic adenosine 3",5"-monophosphate (cAMP) response element binding protein as well as the phosphorylation of extracellular signal-regulated kinase 1/2 in the hypothalamic region, all of which are known to regulate the expression of CRF mRNA.	Quercetin	13-22	mitogen activated protein kinase 3	Rattus norvegicus	217-258
19917299-4	2010	We report here that ginkgo flavonols quercetin and kaempferol stimulates depression-related signaling pathways involving brain-derived neurotrophic factor BDNF/phosphorylation of cyclic AMP response element binding protein CREB/postsynaptic density proteins PSD95, and reduces amyloid-beta peptide (Abeta) in neurons isolated from double transgenic AD mouse (TgAPPswe/PS1e9).	Quercetin	37-46	brain derived neurotrophic factor	Mus musculus	155-159
20395211-6	2010	Three compounds, apigenin, baicalein, and quercetin, decreased Gli1 mRNA concentration but not Gli reporter activity.	Quercetin	42-51	GLI-Kruppel family member GLI1	Mus musculus	63-67
20093625-3	2010	METHODS AND RESULTS: Quercetin and theaflavin (64-mg/kg body mass daily) significantly attenuated atherosclerotic lesion size in the aortic sinus and thoracic aorta (P&lt;0.05 versus ApoE(-/-) control mice).	Quercetin	21-30	apolipoprotein E	Mus musculus	183-187
20093625-4	2010	Quercetin significantly reduced aortic F(2)-isoprostane, vascular superoxide, vascular leukotriene B(4), and plasma-sP-selectin concentrations; and augmented vascular endothelial NO synthase activity, heme oxygenase-1 protein, and urinary nitrate excretion (P&lt;0.05 versus control ApoE(-/-) mice).	Quercetin	0-9	heme oxygenase 1	Mus musculus	201-217
20093625-4	2010	Quercetin significantly reduced aortic F(2)-isoprostane, vascular superoxide, vascular leukotriene B(4), and plasma-sP-selectin concentrations; and augmented vascular endothelial NO synthase activity, heme oxygenase-1 protein, and urinary nitrate excretion (P&lt;0.05 versus control ApoE(-/-) mice).	Quercetin	0-9	apolipoprotein E	Mus musculus	283-287
20093625-8	2010	Quercetin, but not (-)-epicatechin, significantly increased the expression of heme oxygenase-1 protein in lesions versus ApoE(-/-) controls.	Quercetin	0-9	heme oxygenase 1	Mus musculus	78-94
20093625-8	2010	Quercetin, but not (-)-epicatechin, significantly increased the expression of heme oxygenase-1 protein in lesions versus ApoE(-/-) controls.	Quercetin	0-9	apolipoprotein E	Mus musculus	121-125
20093625-9	2010	CONCLUSIONS: Specific dietary polyphenols, in particular quercetin and theaflavin, may attenuate atherosclerosis in ApoE(-/-) gene-knockout mice by alleviating inflammation, improving NO bioavailability, and inducing heme oxygenase-1.	Quercetin	57-66	apolipoprotein E	Mus musculus	116-120
20093625-9	2010	CONCLUSIONS: Specific dietary polyphenols, in particular quercetin and theaflavin, may attenuate atherosclerosis in ApoE(-/-) gene-knockout mice by alleviating inflammation, improving NO bioavailability, and inducing heme oxygenase-1.	Quercetin	57-66	heme oxygenase 1	Mus musculus	217-233
20044584-3	2010	In non-tumor lung tissue from 38 adenocarcinoma patients, we assessed the correlation between quercetin intake and messenger RNA expression of the same P450 and GST metabolic genes.	Quercetin	94-103	glutathione S-transferase kappa 1	Homo sapiens	161-164
20044584-5	2010	Frequent intake of quercetin-rich foods was inversely associated with lung cancer risk (OR = 0.49; 95% CI: 0.37-0.67; P-trend &lt; 0.001) and did not differ by P450 or GST genotypes, gender or histological subtypes.	Quercetin	19-28	glutathione S-transferase kappa 1	Homo sapiens	168-171
20044584-7	2010	Based on a two-sample t-test, we compared gene expression and high versus low consumption of quercetin-rich foods and observed an overall upregulation of GSTM1, GSTM2, GSTT2, and GSTP1 as well as a downregulation of specific P450 genes (P-values &lt; 0.05, adjusted for age and smoking status).	Quercetin	93-102	glutathione S-transferase mu 1	Homo sapiens	154-159
20044584-7	2010	Based on a two-sample t-test, we compared gene expression and high versus low consumption of quercetin-rich foods and observed an overall upregulation of GSTM1, GSTM2, GSTT2, and GSTP1 as well as a downregulation of specific P450 genes (P-values &lt; 0.05, adjusted for age and smoking status).	Quercetin	93-102	glutathione S-transferase mu 2	Homo sapiens	161-166
20044584-7	2010	Based on a two-sample t-test, we compared gene expression and high versus low consumption of quercetin-rich foods and observed an overall upregulation of GSTM1, GSTM2, GSTT2, and GSTP1 as well as a downregulation of specific P450 genes (P-values &lt; 0.05, adjusted for age and smoking status).	Quercetin	93-102	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	168-173
20044584-7	2010	Based on a two-sample t-test, we compared gene expression and high versus low consumption of quercetin-rich foods and observed an overall upregulation of GSTM1, GSTM2, GSTT2, and GSTP1 as well as a downregulation of specific P450 genes (P-values &lt; 0.05, adjusted for age and smoking status).	Quercetin	93-102	glutathione S-transferase pi 1	Homo sapiens	179-184
20300638-5	2010	High performance liquid chromatography (HPLC) and mass spectrometry (MS) showed that quercetin was transformed into a compound with a mass identical to tamarixetin, suggesting that the flavonoid was methylated by catechol-O-methyl transferase (COMT) within platelets.	Quercetin	85-94	catechol-O-methyltransferase	Homo sapiens	213-242
20300638-5	2010	High performance liquid chromatography (HPLC) and mass spectrometry (MS) showed that quercetin was transformed into a compound with a mass identical to tamarixetin, suggesting that the flavonoid was methylated by catechol-O-methyl transferase (COMT) within platelets.	Quercetin	85-94	catechol-O-methyltransferase	Homo sapiens	244-248
20437933-7	2010	RESULTS: The increase in serum S-100beta levels seen in saline controls after spinal cord trauma was ameliorated in the quercetin-treated animals at all time points, although the difference to saline controls became statistically significant only at 24 hrs after the trauma.	Quercetin	120-129	S100 calcium binding protein B	Homo sapiens	31-40
20338103-8	2010	RESULTS: Minimal inhibitory concentration (MIC) of MUC5AC expression of each polyphenol was found as follows: [6]-gingerol, 1 microM; EGCG, 20 microM; quercetin, 40 microM; and curcumin, 10 microM.	Quercetin	151-160	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	51-57
20437933-8	2010	Compared to tissue S-100beta levels in healthy animals, values were significantly decreased in saline controls at all three time points, while they were decreased at 6 hrs and increased at both 12 and 24 hrs in quercetin-treated animals.	Quercetin	211-220	S100 calcium binding protein B	Homo sapiens	19-28
20437933-9	2010	At all three time points tissue S-100beta levels were significantly higher in quercetin-treated animals than in saline controls.	Quercetin	78-87	S100 calcium binding protein B	Homo sapiens	32-41
20437933-10	2010	CONCLUSIONS: Administration of quercetin results in modification of S-100beta levels in the setting of experimental spinal cord trauma.	Quercetin	31-40	S100 calcium binding protein B	Homo sapiens	68-77
20437933-11	2010	The kinetic patterns of the S-100beta fluctuations in serum and tissue suggest that post-traumatic administration of quercetin decreases the extent of CNS injury.	Quercetin	117-126	S100 calcium binding protein B	Homo sapiens	28-37
20535998-0	2010	[EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures].	Quercetin	11-20	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	87-108
19686810-0	2010	Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases.	Quercetin	10-19	fibrinogen beta chain	Homo sapiens	58-68
19686810-3	2010	Quercetin strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	68-74
19686810-3	2010	Quercetin strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	103-106
19686810-3	2010	Quercetin strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	111-117
20535998-3	2010	Blockade of the expression of Hsp70 by quercetin increased the duration of clonic and tonic seizures and did not affect severity of seizures and ataxia symptoms, induced by intraperitoneal injection of pentylenetetrazole.	Quercetin	39-48	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	30-35
20535998-4	2010	Immunoblotting showed that injection of quercetin resulted in reduced content of the inducible form of Hsp70 in the hippocampus, thalamus and corpus callosum.	Quercetin	40-49	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	103-108
20535998-5	2010	The obtained results indicate proconvulsant effect of quercetin associated with the inhibition of Hsp70 expression.	Quercetin	54-63	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	98-103
21787598-4	2010	Moreover, quercetin markedly restored Cu/Zn-SOD, Mn-SOD, CAT and GPx activities and upregulated mRNA expression levels of these proteins in the liver of lead-treated rat.	Quercetin	10-19	superoxide dismutase 1	Rattus norvegicus	38-47
21787598-4	2010	Moreover, quercetin markedly restored Cu/Zn-SOD, Mn-SOD, CAT and GPx activities and upregulated mRNA expression levels of these proteins in the liver of lead-treated rat.	Quercetin	10-19	superoxide dismutase 2	Rattus norvegicus	49-55
21787598-4	2010	Moreover, quercetin markedly restored Cu/Zn-SOD, Mn-SOD, CAT and GPx activities and upregulated mRNA expression levels of these proteins in the liver of lead-treated rat.	Quercetin	10-19	catalase	Rattus norvegicus	57-60
21787598-5	2010	Western blot analysis showed that quercetin significantly inhibited apoptosis by modulating the ratio of Bax to Bcl-2 expression and suppressing the expression of phosphorylated JNK1/2 and cleaved caspase-3 in the liver of lead-treated rat.	Quercetin	34-43	BCL2 associated X, apoptosis regulator	Rattus norvegicus	105-108
21787598-5	2010	Western blot analysis showed that quercetin significantly inhibited apoptosis by modulating the ratio of Bax to Bcl-2 expression and suppressing the expression of phosphorylated JNK1/2 and cleaved caspase-3 in the liver of lead-treated rat.	Quercetin	34-43	BCL2, apoptosis regulator	Rattus norvegicus	112-117
21472244-3	2010	The IC50 value of bortezomib was found to be 2.46 nM, while that of the Hsp70 inhibitor quercetin was 45 microM in the B16F10 cells.	Quercetin	88-97	heat shock protein 1B	Mus musculus	72-77
20060843-7	2010	KEY FINDINGS: Quercetin produced an inhibitory effect on inducible nitric oxide synthase (iNOS) expression and NO production.	Quercetin	14-23	nitric oxide synthase 2, inducible	Mus musculus	57-88
20060843-5	2010	MAIN METHODS: We herein describe a potential regulatory mechanism by which quercetin suppresses nitric oxide (NO) production by lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-stimulated BV-2 microglial cells.	Quercetin	75-84	interferon gamma	Mus musculus	153-169
20684251-2	2010	Quercetin treatment of K-562 cells was accompanied by cell cycle arrest in G2/M and apoptosis with caspase-3 activation.	Quercetin	0-9	caspase 3	Homo sapiens	99-108
20684251-4	2010	In spite of the appearance of benzidine-positive cells and the decreased CD71 level in K-562 cells after exposure to quercetin, the analysis of 1H NMR spectra revealed the overall balance in favor of apoptosis, namely the increase in the content of NMR-visible mobile lipid domains and the decreased intensity of choline-containing metabolites.	Quercetin	117-126	transferrin receptor	Homo sapiens	73-77
20096292-0	2010	Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	19-24
20096292-0	2010	Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5.	Quercetin	0-9	TNF receptor superfamily member 10b	Homo sapiens	103-119
20096292-1	2010	AIMS: Quercetin has been shown to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of prostate cancer cells via mechanisms that include upregulation of death receptor (DR) 5, a protein reported to play an important role in sensitizing cancer cells to apoptosis.	Quercetin	6-15	TNF superfamily member 10	Homo sapiens	42-97
20096292-1	2010	AIMS: Quercetin has been shown to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of prostate cancer cells via mechanisms that include upregulation of death receptor (DR) 5, a protein reported to play an important role in sensitizing cancer cells to apoptosis.	Quercetin	6-15	TNF superfamily member 10	Homo sapiens	99-104
20096292-1	2010	AIMS: Quercetin has been shown to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of prostate cancer cells via mechanisms that include upregulation of death receptor (DR) 5, a protein reported to play an important role in sensitizing cancer cells to apoptosis.	Quercetin	6-15	TNF receptor superfamily member 10b	Homo sapiens	193-214
20096292-2	2010	We aimed to determine the specific mechanisms underlying quercetin-induced DR5 expression.	Quercetin	57-66	TNF receptor superfamily member 10b	Homo sapiens	75-78
20096292-6	2010	KEY FINDINGS: After stimulation with quercetin, DU-145 cells exhibited stronger sensitization to TRAIL.	Quercetin	37-46	TNF superfamily member 10	Homo sapiens	97-102
20060843-5	2010	MAIN METHODS: We herein describe a potential regulatory mechanism by which quercetin suppresses nitric oxide (NO) production by lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-stimulated BV-2 microglial cells.	Quercetin	75-84	interferon gamma	Mus musculus	171-180
20060843-7	2010	KEY FINDINGS: Quercetin produced an inhibitory effect on inducible nitric oxide synthase (iNOS) expression and NO production.	Quercetin	14-23	nitric oxide synthase 2, inducible	Mus musculus	90-94
20096292-7	2010	Quercetin treatment enhanced TRAIL-induced activation proteins in the caspase pathway, such as poly (ADP-ribose) polymerase (PARP), caspase-3, and caspase-9.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	29-34
20096292-7	2010	Quercetin treatment enhanced TRAIL-induced activation proteins in the caspase pathway, such as poly (ADP-ribose) polymerase (PARP), caspase-3, and caspase-9.	Quercetin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	125-129
20060843-8	2010	Biochemical studies revealed that the anti-inflammatory effect of quercetin was accompanied by the down-regulation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38, Akt, Src, Janus kinase-1, Tyk2, signal transducer and activator of transcription-1, and NF-kappaB.	Quercetin	66-75	mitogen-activated protein kinase 14	Mus musculus	182-185
20096292-7	2010	Quercetin treatment enhanced TRAIL-induced activation proteins in the caspase pathway, such as poly (ADP-ribose) polymerase (PARP), caspase-3, and caspase-9.	Quercetin	0-9	caspase 3	Homo sapiens	132-141
20096292-7	2010	Quercetin treatment enhanced TRAIL-induced activation proteins in the caspase pathway, such as poly (ADP-ribose) polymerase (PARP), caspase-3, and caspase-9.	Quercetin	0-9	caspase 9	Homo sapiens	147-156
20060843-8	2010	Biochemical studies revealed that the anti-inflammatory effect of quercetin was accompanied by the down-regulation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38, Akt, Src, Janus kinase-1, Tyk2, signal transducer and activator of transcription-1, and NF-kappaB.	Quercetin	66-75	thymoma viral proto-oncogene 1	Mus musculus	187-190
20096292-8	2010	Quercetin dose-dependently increased DR5 levels in prostate cancer cells, which was mediated by increased transcription and protein stability, but not mRNA stability.	Quercetin	0-9	TNF receptor superfamily member 10b	Homo sapiens	37-40
20060843-8	2010	Biochemical studies revealed that the anti-inflammatory effect of quercetin was accompanied by the down-regulation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38, Akt, Src, Janus kinase-1, Tyk2, signal transducer and activator of transcription-1, and NF-kappaB.	Quercetin	66-75	Rous sarcoma oncogene	Mus musculus	192-195
20060843-8	2010	Biochemical studies revealed that the anti-inflammatory effect of quercetin was accompanied by the down-regulation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38, Akt, Src, Janus kinase-1, Tyk2, signal transducer and activator of transcription-1, and NF-kappaB.	Quercetin	66-75	Janus kinase 1	Mus musculus	197-211
20060843-8	2010	Biochemical studies revealed that the anti-inflammatory effect of quercetin was accompanied by the down-regulation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38, Akt, Src, Janus kinase-1, Tyk2, signal transducer and activator of transcription-1, and NF-kappaB.	Quercetin	66-75	tyrosine kinase 2	Mus musculus	213-217
20060843-8	2010	Biochemical studies revealed that the anti-inflammatory effect of quercetin was accompanied by the down-regulation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38, Akt, Src, Janus kinase-1, Tyk2, signal transducer and activator of transcription-1, and NF-kappaB.	Quercetin	66-75	signal transducer and activator of transcription 1	Mus musculus	219-269
19887118-0	2010	Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin.	Quercetin	104-113	CD63 molecule	Homo sapiens	32-36
20139905-8	2010	This inducing effect of bicyclol on HSP27 and HSF1 was markedly blocked by quercetin.	Quercetin	75-84	heat shock protein family B (small) member 1	Homo sapiens	36-41
20139905-8	2010	This inducing effect of bicyclol on HSP27 and HSF1 was markedly blocked by quercetin.	Quercetin	75-84	heat shock transcription factor 1	Homo sapiens	46-50
19889883-7	2010	Quercetin was a mixed-type inhibitor in HLM and HIM incubations [K(i) = 11.3 (HLM) and 2.8 (HLM) microM], whereas kaempferol was a noncompetitive inhibitor in HLM (K(i) = 33.7 microM) and a mixed-type inhibitor in HIM (K(i) = 4.5 microM).	Quercetin	0-9	oxysterol binding protein 2	Homo sapiens	40-43
19889883-7	2010	Quercetin was a mixed-type inhibitor in HLM and HIM incubations [K(i) = 11.3 (HLM) and 2.8 (HLM) microM], whereas kaempferol was a noncompetitive inhibitor in HLM (K(i) = 33.7 microM) and a mixed-type inhibitor in HIM (K(i) = 4.5 microM).	Quercetin	0-9	oxysterol binding protein 2	Homo sapiens	78-81
19889883-7	2010	Quercetin was a mixed-type inhibitor in HLM and HIM incubations [K(i) = 11.3 (HLM) and 2.8 (HLM) microM], whereas kaempferol was a noncompetitive inhibitor in HLM (K(i) = 33.7 microM) and a mixed-type inhibitor in HIM (K(i) = 4.5 microM).	Quercetin	0-9	oxysterol binding protein 2	Homo sapiens	78-81
19889883-7	2010	Quercetin was a mixed-type inhibitor in HLM and HIM incubations [K(i) = 11.3 (HLM) and 2.8 (HLM) microM], whereas kaempferol was a noncompetitive inhibitor in HLM (K(i) = 33.7 microM) and a mixed-type inhibitor in HIM (K(i) = 4.5 microM).	Quercetin	0-9	oxysterol binding protein 2	Homo sapiens	78-81
19903466-11	2010	Furthermore, quercetin inhibited insulin-stimulated protein kinase B (Akt)- and endothelial NO synthase (eNOS) phosphorylation.	Quercetin	13-22	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
20335952-0	2010	Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	38-52
19887118-0	2010	Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin.	Quercetin	104-113	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	41-47
19887118-5	2010	RESULTS: Quercetin at a dose of 10 microg/ml strongly inhibited CD63 and CD203c membrane up-regulation triggered by both agonists, but it neither affected cell viability nor changed the expression of the phenotypic marker CD123.	Quercetin	9-18	CD63 molecule	Homo sapiens	64-68
19887118-5	2010	RESULTS: Quercetin at a dose of 10 microg/ml strongly inhibited CD63 and CD203c membrane up-regulation triggered by both agonists, but it neither affected cell viability nor changed the expression of the phenotypic marker CD123.	Quercetin	9-18	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	73-79
19887118-6	2010	The anti-IgE model appeared highly sensitive to the effect of quercetin: a dose as low as 0.01 microg/ml was able to significantly decrease CD63 and CD203c membrane expression.	Quercetin	62-71	CD63 molecule	Homo sapiens	140-144
19887118-6	2010	The anti-IgE model appeared highly sensitive to the effect of quercetin: a dose as low as 0.01 microg/ml was able to significantly decrease CD63 and CD203c membrane expression.	Quercetin	62-71	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	149-155
19887118-7	2010	In the fMLP model the dose response was different: quercetin doses from 0.01 to 0.1 microg/ml significantly increased up-regulation of membrane markers, achieving the highest effect with CD63.	Quercetin	51-60	formyl peptide receptor 1	Homo sapiens	7-11
19887118-7	2010	In the fMLP model the dose response was different: quercetin doses from 0.01 to 0.1 microg/ml significantly increased up-regulation of membrane markers, achieving the highest effect with CD63.	Quercetin	51-60	CD63 molecule	Homo sapiens	187-191
19887118-8	2010	CONCLUSION: Very low doses of quercetin, within the pharmacological range, inhibit IgE-mediated membrane marker"s up-regulation but prime the response to the chemotactic peptide fMLP; this stimulus specificity may have implications on the possible therapeutic action of the flavonoid in different pathologies.	Quercetin	30-39	formyl peptide receptor 1	Homo sapiens	178-182
20228421-0	2010	Effect of quercetin on paraoxonase 1 activity--studies in cultured cells, mice and humans.	Quercetin	10-19	paraoxonase 1	Mus musculus	23-36
20136445-7	2010	Quercetin and genistein reduced p53 activity at 1.0 microM, whereas the other four compounds did not attenuate p53 activity.	Quercetin	0-9	transformation related protein 53, pseudogene	Mus musculus	32-35
20032478-0	2010	Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype.	Quercetin	44-53	apolipoprotein E	Homo sapiens	85-101
20032478-6	2010	Quercetin decreased systolic blood pressure by 3.4 mm Hg (P &lt; 0.01) in the apoE3 group, whereas no significant effect was observed in the apoE4 group.	Quercetin	0-9	apolipoprotein E	Homo sapiens	78-83
20032478-7	2010	Quercetin decreased serum HDL cholesterol (P &lt; 0.01) and apoA1 (P &lt; 0.01) and increased the LDL:HDL cholesterol ratio (P &lt; 0.05) in the apoE4 subgroup, whereas the apoE3 subgroup had no significant changes in these variables.	Quercetin	0-9	apolipoprotein A1	Homo sapiens	60-65
20032478-7	2010	Quercetin decreased serum HDL cholesterol (P &lt; 0.01) and apoA1 (P &lt; 0.01) and increased the LDL:HDL cholesterol ratio (P &lt; 0.05) in the apoE4 subgroup, whereas the apoE3 subgroup had no significant changes in these variables.	Quercetin	0-9	apolipoprotein E	Homo sapiens	145-150
20032478-7	2010	Quercetin decreased serum HDL cholesterol (P &lt; 0.01) and apoA1 (P &lt; 0.01) and increased the LDL:HDL cholesterol ratio (P &lt; 0.05) in the apoE4 subgroup, whereas the apoE3 subgroup had no significant changes in these variables.	Quercetin	0-9	apolipoprotein E	Homo sapiens	173-178
20032478-8	2010	Quercetin significantly decreased plasma oxidized LDL and tumor necrosis factor-alpha in the apoE3 and apoE4 groups, whereas no significant inter-group differences were found.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	58-85
20032478-8	2010	Quercetin significantly decreased plasma oxidized LDL and tumor necrosis factor-alpha in the apoE3 and apoE4 groups, whereas no significant inter-group differences were found.	Quercetin	0-9	apolipoprotein E	Homo sapiens	93-98
20032478-8	2010	Quercetin significantly decreased plasma oxidized LDL and tumor necrosis factor-alpha in the apoE3 and apoE4 groups, whereas no significant inter-group differences were found.	Quercetin	0-9	apolipoprotein E	Homo sapiens	103-108
20032478-11	2010	Furthermore, quercetin supplementation resulted in a reduction in HDL cholesterol and apoA1 in apo epsilon4 carriers.	Quercetin	13-22	apolipoprotein A1	Homo sapiens	86-91
20228421-5	2010	Since we could establish a moderate but significant induction of PON1 mRNA levels by dietary quercetin in mice, we aimed to proof whether healthy human volunteers, given graded supplementary quercetin (50, 100 or 150 mg/day) for two weeks, would respond with likewise enhanced plasma paraoxonase activities.	Quercetin	93-102	paraoxonase 1	Mus musculus	65-69
20228421-7	2010	Differences between mice and humans regarding the PON1 inducing activity of quercetin may be related to differences in quercetin metabolism.	Quercetin	76-85	paraoxonase 1	Homo sapiens	50-54
20228421-3	2010	Quercetin, a flavonol frequently present in fruits and vegetables has been shown to induce PON1 in cultured liver cells, but the in vivo efficacy of a dietary quercetin supplementation has yet not been evaluated.	Quercetin	0-9	paraoxonase 1	Homo sapiens	91-95
20228421-7	2010	Differences between mice and humans regarding the PON1 inducing activity of quercetin may be related to differences in quercetin metabolism.	Quercetin	119-128	paraoxonase 1	Homo sapiens	50-54
20228421-8	2010	In mice, unlike in humans, a large proportion of quercetin is methylated to isorhamnetin which exhibits, according to our reporter gene data in cultured liver cells, a potent PON1 inducing activity.	Quercetin	49-58	paraoxonase 1	Homo sapiens	175-179
19914226-7	2010	Interestingly, the most pronounced suppression of development of preneoplastic lesions and their proliferation were observed in the quercetin-fed group, in which the serum leptin level was lowered.	Quercetin	132-141	leptin	Mus musculus	172-178
19449452-6	2010	Quercetin decreased the percentage of Mac-3 and CD11b markers, suggesting that the differentiation of the precursors of macrophages and T cells was inhibited.	Quercetin	0-9	lysosomal-associated membrane protein 2	Mus musculus	38-43
19449452-6	2010	Quercetin decreased the percentage of Mac-3 and CD11b markers, suggesting that the differentiation of the precursors of macrophages and T cells was inhibited.	Quercetin	0-9	integrin alpha M	Mus musculus	48-53
19914226-8	2010	Furthermore, quercetin-feeding decreased leptin mRNA expression and secretion in differentiated 3T3-L1 mouse adipocytes.	Quercetin	13-22	leptin	Mus musculus	41-47
20930378-4	2010	An additive effect was observed after combined treatment with flavanone, naringenin, and chrysin, whereas kaempferol, myricetin, and quercetin decreased CYP1A1 levels.	Quercetin	133-142	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	153-159
19921817-5	2010	On the other hand, combined treatment with luteolin (Lut, 0.5 microM) and quercetin (Que, 0.5 microM) profoundly decreased MDA-MB-231 proliferation by down-regulating alpha9-nAChR expression.	Quercetin	74-83	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	174-179
19921817-5	2010	On the other hand, combined treatment with luteolin (Lut, 0.5 microM) and quercetin (Que, 0.5 microM) profoundly decreased MDA-MB-231 proliferation by down-regulating alpha9-nAChR expression.	Quercetin	85-88	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	174-179
19921817-8	2010	Such results show that Lut- or Que-induced antitransforming activities were not limited to specific inhibition of the alpha9-nAChR receptor.	Quercetin	31-34	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	125-130
20823570-11	2010	Pretreatment with quercetin or thalidomide significantly attenuated the severity of cerulein-induced acute pancreatitis as evidenced by effective reductions in the pancreatic wet weight/body weight ratio, biochemical indices, proinflammatory cytokines, myeloperoxidase activity, malondialdehyde formation, and an increase in antiinflammatory cytokine IL-10.	Quercetin	18-27	myeloperoxidase	Mus musculus	253-268
20823570-11	2010	Pretreatment with quercetin or thalidomide significantly attenuated the severity of cerulein-induced acute pancreatitis as evidenced by effective reductions in the pancreatic wet weight/body weight ratio, biochemical indices, proinflammatory cytokines, myeloperoxidase activity, malondialdehyde formation, and an increase in antiinflammatory cytokine IL-10.	Quercetin	18-27	interleukin 10	Mus musculus	351-356
20823570-12	2010	Quercetin treatment also markedly suppressed the histological changes such as pancreatic edema, inflammatory cell infiltration, acinar cell necrosis, and the expression of TNF-alpha.	Quercetin	0-9	tumor necrosis factor	Mus musculus	172-181
20823584-8	2010	In oocytes injected with cRNAs coding AMPA receptor (GluR1) and stargazin, quercetin inhibited IGlu in a reversible and concentration-dependent manner.	Quercetin	75-84	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	53-58
20823584-8	2010	In oocytes injected with cRNAs coding AMPA receptor (GluR1) and stargazin, quercetin inhibited IGlu in a reversible and concentration-dependent manner.	Quercetin	75-84	calcium voltage-gated channel auxiliary subunit gamma 2	Homo sapiens	64-73
20699555-4	2010	Furthermore, kaempferol and quercetin increased the activity of thioredoxin reductase in normal human keratinocytes.	Quercetin	28-37	peroxiredoxin 5	Homo sapiens	64-85
20132735-4	2010	In this study, we observed that several flavonoids-kaempferol, quercetin, fisetin, and chrysin-inhibit LPS-induced IL-8 promoter activation in RAW 264.7 cells.	Quercetin	63-72	chemokine (C-X-C motif) ligand 15	Mus musculus	115-119
19466611-11	2010	Further study showed that quercetin suppressed intratumoral HIF-1alpha in a hypoxia-dependent way but increased its accumulation in normal cells.	Quercetin	26-35	hypoxia inducible factor 1, alpha subunit	Mus musculus	60-70
19466611-12	2010	HIF-1alpha siRNA abolished effects of quercetin on both tumor and normal cells.	Quercetin	38-47	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-10
19466611-0	2010	Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1alpha in tumor and normal cells.	Quercetin	0-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	113-123
19466611-13	2010	CONCLUSIONS: These results suggested that quercetin could improve therapeutic index of DOX by its opposing effects on HIF-1alpha in tumor and normal cells, and was a promising candidate as anticancer agents.	Quercetin	42-51	hypoxia inducible factor 1, alpha subunit	Mus musculus	118-128
19941471-13	2010	Among polyphenols, curcumin and some flavonoids such as myricetin and quercetin, have been identified as potential anticancer agents with a mechanism of action that may be mediated by the Trx system.	Quercetin	70-79	thioredoxin	Homo sapiens	188-191
21228504-0	2010	Quercetin enhances VDR activity, leading to stimulation of its target gene expression in Caco-2 cells.	Quercetin	0-9	vitamin D receptor	Homo sapiens	19-22
19879672-1	2010	Selected flavonoids: galangin, kaempferol, quercetin, myricetin, fisetin, apigenin, luteolin and rutin, reversibly inhibited human butyrylcholinesterase (BChE, EC 3.1.1.8).	Quercetin	43-52	butyrylcholinesterase	Homo sapiens	131-152
19879672-1	2010	Selected flavonoids: galangin, kaempferol, quercetin, myricetin, fisetin, apigenin, luteolin and rutin, reversibly inhibited human butyrylcholinesterase (BChE, EC 3.1.1.8).	Quercetin	43-52	butyrylcholinesterase	Homo sapiens	154-158
21228504-3	2010	Using a VDR-driven luciferase expression assay for screening a naturally occurring food component, we identified quercetin as a VDR activator.	Quercetin	113-122	vitamin D receptor	Homo sapiens	8-11
21228504-3	2010	Using a VDR-driven luciferase expression assay for screening a naturally occurring food component, we identified quercetin as a VDR activator.	Quercetin	113-122	vitamin D receptor	Homo sapiens	128-131
21228504-4	2010	Quercetin also activated the GAL4 DNA-binding domain fused to the VDR ligand-binding domain.	Quercetin	0-9	vitamin D receptor	Homo sapiens	66-69
21228504-5	2010	Moreover, it was confirmed that quercetin increases the mRNA level of TRPV6, which is a VDR target gene, in Caco-2 cells.	Quercetin	32-41	transient receptor potential cation channel subfamily V member 6	Homo sapiens	70-75
21228504-5	2010	Moreover, it was confirmed that quercetin increases the mRNA level of TRPV6, which is a VDR target gene, in Caco-2 cells.	Quercetin	32-41	vitamin D receptor	Homo sapiens	88-91
21228504-6	2010	These results indicate that quercetin enhances VDR activity through the alteration of cofactor recruitment, thereby stimulating its target genes while providing a new function for quercetin as the VDR activator.	Quercetin	28-37	vitamin D receptor	Homo sapiens	47-50
21228504-6	2010	These results indicate that quercetin enhances VDR activity through the alteration of cofactor recruitment, thereby stimulating its target genes while providing a new function for quercetin as the VDR activator.	Quercetin	28-37	vitamin D receptor	Homo sapiens	197-200
21228504-6	2010	These results indicate that quercetin enhances VDR activity through the alteration of cofactor recruitment, thereby stimulating its target genes while providing a new function for quercetin as the VDR activator.	Quercetin	180-189	vitamin D receptor	Homo sapiens	47-50
21228504-6	2010	These results indicate that quercetin enhances VDR activity through the alteration of cofactor recruitment, thereby stimulating its target genes while providing a new function for quercetin as the VDR activator.	Quercetin	180-189	vitamin D receptor	Homo sapiens	197-200
20816012-0	2010	Evaluation of protective effect of a water-in-oil microemulsion incorporating quercetin against UVB-induced damage in hairless mice skin.	Quercetin	78-87	lysine demethylase and nuclear receptor corepressor	Mus musculus	118-126
20093793-5	2010	Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol.	Quercetin	33-42	heat shock protein 1B	Mus musculus	60-65
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Quercetin	37-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	171-176
20054739-10	2010	The mean difference in VO(2max) change from pre to post between groups (quercetin vs. placebo) was 0.139 ml x kg(-1) x min(-1) (P = 0.780).	Quercetin	72-81	CD59 molecule (CD59 blood group)	Homo sapiens	119-125
21092705-9	2010	Further, in EAM rats treated with quercetin levels of TNF-alpha and IL-17 were significantly lower, while the level of IL-10 was significantly higher both in serum and culture supernatants of LNC stimulated with concanavalin A compared with vehicle-treated animals.	Quercetin	34-43	tumor necrosis factor	Rattus norvegicus	54-63
21092705-9	2010	Further, in EAM rats treated with quercetin levels of TNF-alpha and IL-17 were significantly lower, while the level of IL-10 was significantly higher both in serum and culture supernatants of LNC stimulated with concanavalin A compared with vehicle-treated animals.	Quercetin	34-43	interleukin 17A	Rattus norvegicus	68-73
21092705-9	2010	Further, in EAM rats treated with quercetin levels of TNF-alpha and IL-17 were significantly lower, while the level of IL-10 was significantly higher both in serum and culture supernatants of LNC stimulated with concanavalin A compared with vehicle-treated animals.	Quercetin	34-43	interleukin 10	Rattus norvegicus	119-124
21092705-10	2010	CONCLUSIONS: The present study suggests that quercetin ameliorates EAM, at least in part, by interfering production of proinflammatory (TNF-alpha and IL-17) and/or anti-inflammatory (IL-10) cytokines.	Quercetin	45-54	tumor necrosis factor	Rattus norvegicus	136-145
21092705-10	2010	CONCLUSIONS: The present study suggests that quercetin ameliorates EAM, at least in part, by interfering production of proinflammatory (TNF-alpha and IL-17) and/or anti-inflammatory (IL-10) cytokines.	Quercetin	45-54	interleukin 17A	Rattus norvegicus	150-155
21092705-10	2010	CONCLUSIONS: The present study suggests that quercetin ameliorates EAM, at least in part, by interfering production of proinflammatory (TNF-alpha and IL-17) and/or anti-inflammatory (IL-10) cytokines.	Quercetin	45-54	interleukin 10	Rattus norvegicus	183-188
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Quercetin	37-46	matrix metallopeptidase 9	Homo sapiens	196-201
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Quercetin	37-46	small nucleolar RNA, C/D box 87	Homo sapiens	246-249
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Quercetin	48-50	prostaglandin-endoperoxide synthase 2	Homo sapiens	171-176
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Quercetin	48-50	matrix metallopeptidase 9	Homo sapiens	196-201
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Quercetin	48-50	small nucleolar RNA, C/D box 87	Homo sapiens	246-249
21058190-3	2010	Although quercetin induced cell death in a dose-dependent manner, 12.5-50 muM quercetin inhibited the activity of both taxol and nocodazole to induce G2/M arrest in various cell lines.	Quercetin	78-87	latexin	Homo sapiens	74-77
20358477-0	2010	Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cells.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	20-30
20358477-0	2010	Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cells.	Quercetin	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-39
20358477-0	2010	Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cells.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	40-43
20358477-2	2010	The aim of this study was to investigate the regulatory effect of quercetin (50 microM) on two main transcription factors (NF-kappa B and AP-1) related to survival/proliferation pathways in a human hepatoma cell line (HepG2) over time.	Quercetin	66-75	nuclear factor kappa B subunit 1	Homo sapiens	123-133
20358477-2	2010	The aim of this study was to investigate the regulatory effect of quercetin (50 microM) on two main transcription factors (NF-kappa B and AP-1) related to survival/proliferation pathways in a human hepatoma cell line (HepG2) over time.	Quercetin	66-75	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-142
20358477-3	2010	Quercetin induced a significant time-dependent inactivation of the NF-kappa B pathway consistent with a downregulation of the NF-kappa B binding activity (from 15 min onward).	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	67-77
20358477-3	2010	Quercetin induced a significant time-dependent inactivation of the NF-kappa B pathway consistent with a downregulation of the NF-kappa B binding activity (from 15 min onward).	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	126-136
21058190-4	2010	Quercetin also partially restored drug-induced loss in viability of treated cells for up to 72 h. This antagonism of microtubule-targeting drugs was accompanied by a delay in cell cycle progression and inhibition of the buildup of cyclin-B1 at the microtubule organizing center of treated cells.	Quercetin	0-9	cyclin B1	Homo sapiens	231-240
20358477-5	2010	These data suggest that NF-kappa B and AP-1 play a main role in the tight regulation of survival/proliferation pathways exerted by quercetin and that the sustained JNK/AP-1 activation and inhibition of NF-kappa B provoked by the flavonoid induced HepG2 death.	Quercetin	131-140	nuclear factor kappa B subunit 1	Homo sapiens	24-34
19688719-0	2010	Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons.	Quercetin	0-9	carbonic anhydrase 1	Rattus norvegicus	139-142
20358477-5	2010	These data suggest that NF-kappa B and AP-1 play a main role in the tight regulation of survival/proliferation pathways exerted by quercetin and that the sustained JNK/AP-1 activation and inhibition of NF-kappa B provoked by the flavonoid induced HepG2 death.	Quercetin	131-140	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-43
20358477-5	2010	These data suggest that NF-kappa B and AP-1 play a main role in the tight regulation of survival/proliferation pathways exerted by quercetin and that the sustained JNK/AP-1 activation and inhibition of NF-kappa B provoked by the flavonoid induced HepG2 death.	Quercetin	131-140	nuclear factor kappa B subunit 1	Homo sapiens	202-212
19705161-6	2010	Addition of quercetin resulted in decreased expression of HSP-72, increased mesothelial cell exfoliation, and higher peritoneal protein loss.	Quercetin	12-21	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	58-64
19688719-6	2010	Also, in acutely isolated rat hippocampal CA1 pyramidal neurons, quercetin (0.3, 3 and 30 microm) decreased the amplitude of voltage-dependent sodium currents in a dose- and voltage-dependent manner.	Quercetin	65-74	carbonic anhydrase 1	Rattus norvegicus	42-45
19798679-0	2009	Quercetin-induced upregulation of human GCLC gene is mediated by cis-regulatory element for early growth response protein-1 (EGR1) in INS-1 beta-cells.	Quercetin	0-9	glutamate-cysteine ligase catalytic subunit	Homo sapiens	40-44
19896375-0	2009	Structural insights into IKKbeta inhibition by natural products staurosporine and quercetin.	Quercetin	82-91	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	25-32
19896375-1	2009	This Letter describes the results of two combined approaches: homology modeling and molecular docking studies, in order to propose the molecular basis of IKKbeta inhibition by staurosporine and quercetin as ATP-competitive inhibitors.	Quercetin	194-203	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	154-161
19798679-0	2009	Quercetin-induced upregulation of human GCLC gene is mediated by cis-regulatory element for early growth response protein-1 (EGR1) in INS-1 beta-cells.	Quercetin	0-9	early growth response 1	Homo sapiens	92-123
19798679-0	2009	Quercetin-induced upregulation of human GCLC gene is mediated by cis-regulatory element for early growth response protein-1 (EGR1) in INS-1 beta-cells.	Quercetin	0-9	early growth response 1	Homo sapiens	125-129
19798679-3	2009	In the present study, we investigated the regulatory mechanisms by which quercetin, a flavonoid, induces the expression of the GCLC gene in rat pancreatic beta-cell line INS-1.	Quercetin	73-82	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	127-131
19798679-4	2009	Promoter study found that the proximal GC-rich region (from -90 to -34) of the GCLC promoter contained the quercetin-responsive cis-element(s).	Quercetin	107-116	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	79-83
19766177-5	2009	Genistein, quercetin and chrysin provoked a dose-dependent inducing effect on the CYP1A1 activity, measured with the EROD assay.	Quercetin	11-20	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-88
19798679-5	2009	The quercetin-responsive region contains consensus DNA binding site for early growth response 1 (EGR1) at -67 (5"-CGCCTCCGC-3") which overlaps with a putative Sp1 binding site.	Quercetin	4-13	early growth response 1	Rattus norvegicus	97-101
19766177-9	2009	Quercetin was also shown to significantly inhibit the constitutive CYP3A4 activity, measured by the 6beta-(OH)-testosterone assay, and to impair its induction by 1,25-vitamin D(3).	Quercetin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-73
19766177-10	2009	Chrysin, quercetin and genistein, were detected as significant inhibitors of the 1,25-vitamin D(3)-induced CYP3A4 activity.	Quercetin	9-18	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	107-113
19798679-7	2009	In the promoter analysis, mutation of EGR1 site significantly reduced the quercetin response, whereas mutation of Sp1 site decreased only the basal activity of the GCLC promoter.	Quercetin	74-83	early growth response 1	Rattus norvegicus	38-42
19798679-9	2009	Finally, we showed that quercetin potently induced both EGR1 mRNA and its protein levels without affecting the expression of Sp1 and Sp3 proteins.	Quercetin	24-33	early growth response 1	Rattus norvegicus	56-60
19798679-10	2009	Therefore, we concluded that EGR1 was bound to GC-rich region of the GCLC gene promoter, which was prerequisite for the transactivation of the GCLC gene by quercetin.	Quercetin	156-165	early growth response 1	Rattus norvegicus	29-33
19798679-10	2009	Therefore, we concluded that EGR1 was bound to GC-rich region of the GCLC gene promoter, which was prerequisite for the transactivation of the GCLC gene by quercetin.	Quercetin	156-165	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	69-73
19798679-10	2009	Therefore, we concluded that EGR1 was bound to GC-rich region of the GCLC gene promoter, which was prerequisite for the transactivation of the GCLC gene by quercetin.	Quercetin	156-165	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	143-147
19265175-0	2009	Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.	Quercetin	0-9	high mobility group box 1	Homo sapiens	31-56
19265175-4	2009	Here, we report that quercetin attenuates lethal systemic inflammation caused by endotoxemia, even if treatment is started after the early TNF response.	Quercetin	21-30	tumor necrosis factor	Homo sapiens	139-142
19251944-2	2009	The present study reports that quercetin (a flavonoid) stimulated bumetanide-sensitive Cl(-) secretion with reduction of apical Cl(-) conductance, suggesting that quercetin stimulates Cl(-) secretion by activating an entry step of Cl(-) across the basolateral membrane through Na(+)/K(+)/2Cl(-) cotransporter (NKCC1).	Quercetin	31-40	solute carrier family 12 member 2	Homo sapiens	310-315
19265175-5	2009	Quercetin treatment reduced circulating levels of HMGB1 in animals with established endotoxemia.	Quercetin	0-9	high mobility group box 1	Homo sapiens	50-55
19251944-2	2009	The present study reports that quercetin (a flavonoid) stimulated bumetanide-sensitive Cl(-) secretion with reduction of apical Cl(-) conductance, suggesting that quercetin stimulates Cl(-) secretion by activating an entry step of Cl(-) across the basolateral membrane through Na(+)/K(+)/2Cl(-) cotransporter (NKCC1).	Quercetin	163-172	solute carrier family 12 member 2	Homo sapiens	310-315
19251944-3	2009	To clarify the mechanism stimulating NKCC1 by quercetin, we verified involvement of protein kinase (PK)A, PKC, protein tyrosine kinase (PTK), and cytosolic Ca(2+)-dependent pathways.	Quercetin	46-55	solute carrier family 12 member 2	Homo sapiens	37-42
19265175-6	2009	In macrophage cultures, quercetin inhibited release as well as the cytokine activities of HMGB1, including limiting the activation of mitogen-activated protein kinase and NF-kappaB, two signaling pathways that are critical for HMGB1-induced subsequent cytokine release.	Quercetin	24-33	high mobility group box 1	Homo sapiens	90-95
19251944-7	2009	However, the surface density of NKCC1 was not increased by quercetin, but quercetin elevated the activity of NKCC1.	Quercetin	74-83	solute carrier family 12 member 2	Homo sapiens	109-114
19265175-6	2009	In macrophage cultures, quercetin inhibited release as well as the cytokine activities of HMGB1, including limiting the activation of mitogen-activated protein kinase and NF-kappaB, two signaling pathways that are critical for HMGB1-induced subsequent cytokine release.	Quercetin	24-33	high mobility group box 1	Homo sapiens	227-232
19251944-8	2009	These observations indicate that quercetin stimulates Cl(-) secretion by activating NKCC1 via translocation of an NKCC1-activating factor through an EGFR kinase-dependent pathway.	Quercetin	33-42	solute carrier family 12 member 2	Homo sapiens	84-89
19251944-8	2009	These observations indicate that quercetin stimulates Cl(-) secretion by activating NKCC1 via translocation of an NKCC1-activating factor through an EGFR kinase-dependent pathway.	Quercetin	33-42	solute carrier family 12 member 2	Homo sapiens	114-119
19265175-7	2009	Quercetin and autophagic inhibitor, wortmannin, inhibited LPS-induced type-II microtubule-associated protein 1A/1B-light chain 3 production and aggregation, as well as HMGB1 translocation and release, suggesting a potential association between autophagy and HMGB1 release.	Quercetin	0-9	high mobility group box 1	Homo sapiens	168-173
19251944-8	2009	These observations indicate that quercetin stimulates Cl(-) secretion by activating NKCC1 via translocation of an NKCC1-activating factor through an EGFR kinase-dependent pathway.	Quercetin	33-42	epidermal growth factor receptor	Homo sapiens	149-153
19265175-7	2009	Quercetin and autophagic inhibitor, wortmannin, inhibited LPS-induced type-II microtubule-associated protein 1A/1B-light chain 3 production and aggregation, as well as HMGB1 translocation and release, suggesting a potential association between autophagy and HMGB1 release.	Quercetin	0-9	high mobility group box 1	Homo sapiens	258-263
19265175-8	2009	Quercetin delivery, a strategy to pharmacologically inhibit HMGB1 release that is effective at clinically achievable concentrations, now warrants further evaluation in sepsis and other systemic inflammatory disorders.	Quercetin	0-9	high mobility group box 1	Homo sapiens	60-65
20032413-6	2009	Quercetin decreased the level of Notch1 protein and its active fragment in the DND-41 T-lymphoblastic leukemia cell line with constitutive Notch activation.	Quercetin	0-9	notch receptor 1	Homo sapiens	33-39
19737624-3	2009	In this study, quercetin was initially suggested as a shared substrate for CYP6AS1, CYP6AS3, and CYP6AS4, by its presence in honey, extracts of which induce transcription of these three genes, and by in silico substrate predictions based on a molecular model of CYP6AS3.	Quercetin	15-24	probable cytochrome P450 6a14	Apis mellifera	84-91
19737624-3	2009	In this study, quercetin was initially suggested as a shared substrate for CYP6AS1, CYP6AS3, and CYP6AS4, by its presence in honey, extracts of which induce transcription of these three genes, and by in silico substrate predictions based on a molecular model of CYP6AS3.	Quercetin	15-24	probable cytochrome P450 6a17	Apis mellifera	97-104
19737624-3	2009	In this study, quercetin was initially suggested as a shared substrate for CYP6AS1, CYP6AS3, and CYP6AS4, by its presence in honey, extracts of which induce transcription of these three genes, and by in silico substrate predictions based on a molecular model of CYP6AS3.	Quercetin	15-24	probable cytochrome P450 6a14	Apis mellifera	262-269
19737624-5	2009	CYP6AS1, CYP6AS3, CYP6AS4 and CYP6AS10 metabolize quercetin at rates of 0.5+/-0.1, 0.5+/-0.1, 0.2+/-0.1, and 0.2+/-0.1 pmol quercetin/ pmol P450/min, respectively.	Quercetin	50-59	CYP6AS1	Apis mellifera	0-7
19737624-5	2009	CYP6AS1, CYP6AS3, CYP6AS4 and CYP6AS10 metabolize quercetin at rates of 0.5+/-0.1, 0.5+/-0.1, 0.2+/-0.1, and 0.2+/-0.1 pmol quercetin/ pmol P450/min, respectively.	Quercetin	50-59	probable cytochrome P450 6a14	Apis mellifera	9-16
19737624-5	2009	CYP6AS1, CYP6AS3, CYP6AS4 and CYP6AS10 metabolize quercetin at rates of 0.5+/-0.1, 0.5+/-0.1, 0.2+/-0.1, and 0.2+/-0.1 pmol quercetin/ pmol P450/min, respectively.	Quercetin	50-59	probable cytochrome P450 6a17	Apis mellifera	18-25
19737624-5	2009	CYP6AS1, CYP6AS3, CYP6AS4 and CYP6AS10 metabolize quercetin at rates of 0.5+/-0.1, 0.5+/-0.1, 0.2+/-0.1, and 0.2+/-0.1 pmol quercetin/ pmol P450/min, respectively.	Quercetin	50-59	probable cytochrome P450 6a14	Apis mellifera	30-38
19737624-5	2009	CYP6AS1, CYP6AS3, CYP6AS4 and CYP6AS10 metabolize quercetin at rates of 0.5+/-0.1, 0.5+/-0.1, 0.2+/-0.1, and 0.2+/-0.1 pmol quercetin/ pmol P450/min, respectively.	Quercetin	124-133	CYP6AS1	Apis mellifera	0-7
19737624-5	2009	CYP6AS1, CYP6AS3, CYP6AS4 and CYP6AS10 metabolize quercetin at rates of 0.5+/-0.1, 0.5+/-0.1, 0.2+/-0.1, and 0.2+/-0.1 pmol quercetin/ pmol P450/min, respectively.	Quercetin	124-133	probable cytochrome P450 6a17	Apis mellifera	18-25
19737624-5	2009	CYP6AS1, CYP6AS3, CYP6AS4 and CYP6AS10 metabolize quercetin at rates of 0.5+/-0.1, 0.5+/-0.1, 0.2+/-0.1, and 0.2+/-0.1 pmol quercetin/ pmol P450/min, respectively.	Quercetin	124-133	probable cytochrome P450 6a14	Apis mellifera	30-38
19737624-6	2009	Substrate dockings and sequence alignments revealed that the positively charged amino acids His107 and Lys217 and the carbonyl group of the backbone between Leu302 and Ala303 are essential for quercetin orientation in the CYP6AS3 catalytic site and its efficient metabolism.	Quercetin	193-202	probable cytochrome P450 6a14	Apis mellifera	222-229
19737624-7	2009	Multiple replacements in the catalytic site of CYP6AS4 and CYP6AS10 and repositioning of the quercetin molecule likely account for the lower metabolic activities of CYP6AS4 and CYP6AS10 compared to CYP6AS1 and CYP6AS3.	Quercetin	93-102	probable cytochrome P450 6a17	Apis mellifera	47-54
19737624-7	2009	Multiple replacements in the catalytic site of CYP6AS4 and CYP6AS10 and repositioning of the quercetin molecule likely account for the lower metabolic activities of CYP6AS4 and CYP6AS10 compared to CYP6AS1 and CYP6AS3.	Quercetin	93-102	probable cytochrome P450 6a17	Apis mellifera	165-172
19737624-7	2009	Multiple replacements in the catalytic site of CYP6AS4 and CYP6AS10 and repositioning of the quercetin molecule likely account for the lower metabolic activities of CYP6AS4 and CYP6AS10 compared to CYP6AS1 and CYP6AS3.	Quercetin	93-102	probable cytochrome P450 6a14	Apis mellifera	177-185
19737624-7	2009	Multiple replacements in the catalytic site of CYP6AS4 and CYP6AS10 and repositioning of the quercetin molecule likely account for the lower metabolic activities of CYP6AS4 and CYP6AS10 compared to CYP6AS1 and CYP6AS3.	Quercetin	93-102	probable cytochrome P450 6a14	Apis mellifera	210-217
19729006-0	2009	Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells.	Quercetin	57-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
19729006-0	2009	Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells.	Quercetin	57-66	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-33
19729006-5	2009	Quercetin (10 and 30 microM) induced a time-dependent increase in HIF-1alpha protein levels.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-76
19729006-6	2009	Quercetin (30 microM) was also responsible for a rapid and long-lasting translocation of HIF-1alpha from the cytoplasm to the nucleus.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
19729006-7	2009	Activation of HIF-1 signaling by quercetin was confirmed by qRT-PCR which showed upregulation of the HIF-1 regulated genes EPO, VEGF, PGK1 and BNIP3.	Quercetin	33-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-19
19729006-7	2009	Activation of HIF-1 signaling by quercetin was confirmed by qRT-PCR which showed upregulation of the HIF-1 regulated genes EPO, VEGF, PGK1 and BNIP3.	Quercetin	33-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-106
19729006-7	2009	Activation of HIF-1 signaling by quercetin was confirmed by qRT-PCR which showed upregulation of the HIF-1 regulated genes EPO, VEGF, PGK1 and BNIP3.	Quercetin	33-42	erythropoietin	Homo sapiens	123-126
19729006-7	2009	Activation of HIF-1 signaling by quercetin was confirmed by qRT-PCR which showed upregulation of the HIF-1 regulated genes EPO, VEGF, PGK1 and BNIP3.	Quercetin	33-42	vascular endothelial growth factor A	Homo sapiens	128-132
19729006-7	2009	Activation of HIF-1 signaling by quercetin was confirmed by qRT-PCR which showed upregulation of the HIF-1 regulated genes EPO, VEGF, PGK1 and BNIP3.	Quercetin	33-42	phosphoglycerate kinase 1	Homo sapiens	134-138
19729006-7	2009	Activation of HIF-1 signaling by quercetin was confirmed by qRT-PCR which showed upregulation of the HIF-1 regulated genes EPO, VEGF, PGK1 and BNIP3.	Quercetin	33-42	BCL2 interacting protein 3	Homo sapiens	143-148
19729006-8	2009	Analysis of medium taken from FHL-124 cells showed a sustained dose-dependent increase in VEGF secretion following quercetin treatment.	Quercetin	115-124	vascular endothelial growth factor A	Homo sapiens	90-94
19729006-9	2009	The quercetin-induced increase and nuclear translocation of HIF-1alpha was reversed by addition of excess iron (100 microM).	Quercetin	4-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
19729006-10	2009	These results demonstrate that quercetin activates the HIF-1 signaling pathway in human lens epithelial cells.	Quercetin	31-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-60
19839005-11	2009	The marked inhibition of virus production by Quercetin may partially be related to reduction of HSP40 and HSP70 and their potential involvement in IRES translation, as well as viral morphogenesis or secretion.	Quercetin	45-54	DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1	Homo sapiens	96-101
19839005-11	2009	The marked inhibition of virus production by Quercetin may partially be related to reduction of HSP40 and HSP70 and their potential involvement in IRES translation, as well as viral morphogenesis or secretion.	Quercetin	45-54	heat shock protein family A (Hsp70) member 4	Homo sapiens	106-111
19466539-5	2009	We also demonstrated that resveratrol or quercetin modulates mRNA levels and protein expression of Bax, a pro-apoptotic gene, and Bcl-2, an anti-apoptotic gene.	Quercetin	41-50	BCL2 associated X, apoptosis regulator	Homo sapiens	99-102
19466539-5	2009	We also demonstrated that resveratrol or quercetin modulates mRNA levels and protein expression of Bax, a pro-apoptotic gene, and Bcl-2, an anti-apoptotic gene.	Quercetin	41-50	BCL2 apoptosis regulator	Homo sapiens	130-135
19737624-3	2009	In this study, quercetin was initially suggested as a shared substrate for CYP6AS1, CYP6AS3, and CYP6AS4, by its presence in honey, extracts of which induce transcription of these three genes, and by in silico substrate predictions based on a molecular model of CYP6AS3.	Quercetin	15-24	CYP6AS1	Apis mellifera	75-82
19367675-0	2009	Kaempferol and quercetin, essential ingredients in Ginkgo biloba extract, inhibit interleukin-1beta-induced MUC5AC gene expression in human airway epithelial cells.	Quercetin	15-24	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	108-114
19367675-4	2009	The results showed that kaempferol (KP) and quercetin (QC) suppressed MUC5AC mRNA expression in a dose-dependent manner, both with significant inhibition starting from 40 microm (equal concentration to about a twelfth or thirteenth dose of GBE).	Quercetin	44-53	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	70-76
19949288-4	2009	The IC(50) of quercetin, b-40, and b-41 were 1.4, 0.38, and 6.21 microM, respectively, for binding of HuR protein to TNF-alpha mRNA.	Quercetin	14-23	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	102-105
19949288-4	2009	The IC(50) of quercetin, b-40, and b-41 were 1.4, 0.38, and 6.21 microM, respectively, for binding of HuR protein to TNF-alpha mRNA.	Quercetin	14-23	tumor necrosis factor	Mus musculus	117-126
19949288-6	2009	When LPS-treated RAW264.7 cells were treated with quercetin and b-40, we observed decreased stability of TNF-alpha mRNA and decreased levels of secreted TNF-alpha.	Quercetin	50-59	tumor necrosis factor	Mus musculus	105-114
19949288-6	2009	When LPS-treated RAW264.7 cells were treated with quercetin and b-40, we observed decreased stability of TNF-alpha mRNA and decreased levels of secreted TNF-alpha.	Quercetin	50-59	tumor necrosis factor	Mus musculus	153-162
20032413-6	2009	Quercetin decreased the level of Notch1 protein and its active fragment in the DND-41 T-lymphoblastic leukemia cell line with constitutive Notch activation.	Quercetin	0-9	notch receptor 1	Homo sapiens	33-38
19814731-0	2009	Differential effects of quercetin, apigenin and genistein on signalling pathways of protease-activated receptors PAR(1) and PAR(4) in platelets.	Quercetin	24-33	coagulation factor II thrombin receptor	Homo sapiens	113-119
19565191-5	2009	More favorable complexation between succinyl-beta-CD and quercetin may enhance relative selectivity to quercetin of the (succinyl-beta-CD + MWNT)/GCE in quercetin-rutin mixture as compared to the beta-CD-modified GCE.	Quercetin	57-66	aminomethyltransferase	Homo sapiens	146-149
19565191-5	2009	More favorable complexation between succinyl-beta-CD and quercetin may enhance relative selectivity to quercetin of the (succinyl-beta-CD + MWNT)/GCE in quercetin-rutin mixture as compared to the beta-CD-modified GCE.	Quercetin	57-66	aminomethyltransferase	Homo sapiens	213-216
19565191-5	2009	More favorable complexation between succinyl-beta-CD and quercetin may enhance relative selectivity to quercetin of the (succinyl-beta-CD + MWNT)/GCE in quercetin-rutin mixture as compared to the beta-CD-modified GCE.	Quercetin	103-112	aminomethyltransferase	Homo sapiens	146-149
19565191-5	2009	More favorable complexation between succinyl-beta-CD and quercetin may enhance relative selectivity to quercetin of the (succinyl-beta-CD + MWNT)/GCE in quercetin-rutin mixture as compared to the beta-CD-modified GCE.	Quercetin	103-112	aminomethyltransferase	Homo sapiens	213-216
19814731-0	2009	Differential effects of quercetin, apigenin and genistein on signalling pathways of protease-activated receptors PAR(1) and PAR(4) in platelets.	Quercetin	24-33	Prader Willi/Angelman region RNA 4	Homo sapiens	124-129
19814731-5	2009	KEY RESULTS: Quercetin, apigenin and genistein impaired platelet aggregation, as well as 5-HT release and calcium mobilization, induced by thrombin and PAR-APs.	Quercetin	13-22	coagulation factor II, thrombin	Homo sapiens	139-147
19814731-5	2009	KEY RESULTS: Quercetin, apigenin and genistein impaired platelet aggregation, as well as 5-HT release and calcium mobilization, induced by thrombin and PAR-APs.	Quercetin	13-22	jumping translocation breakpoint	Homo sapiens	152-155
19814765-5	2009	Inhibition of the beta-catenin signaling pathway using quercetin prevented increases in cell proliferation and the protein content of collagen-I and active/dephosphorylated beta-catenin in lung fibroblasts, and in COL1A1 mRNA levels and collagen release into culture medium induced by alpha-defensin-1 and alpha-defensin-2.	Quercetin	55-64	catenin beta 1	Homo sapiens	18-30
19632288-3	2009	The effects of MSBE, mangiferin, norathyriol, catechin, quercetin and gallic acid on P-gp activity were tested by the rhodamine-123 accumulation as well as by the Calcein-AM assays.	Quercetin	56-65	phosphoglycolate phosphatase	Homo sapiens	85-89
19632288-5	2009	All investigated compounds except for catechin and gallic acid inhibited P-gp activity in HK-2 cells, in the order of mangiferin&lt;norathyriol&lt;quercetin&lt;MSBE.	Quercetin	147-156	phosphoglycolate phosphatase	Homo sapiens	73-77
19814765-5	2009	Inhibition of the beta-catenin signaling pathway using quercetin prevented increases in cell proliferation and the protein content of collagen-I and active/dephosphorylated beta-catenin in lung fibroblasts, and in COL1A1 mRNA levels and collagen release into culture medium induced by alpha-defensin-1 and alpha-defensin-2.	Quercetin	55-64	catenin beta 1	Homo sapiens	173-185
19814765-5	2009	Inhibition of the beta-catenin signaling pathway using quercetin prevented increases in cell proliferation and the protein content of collagen-I and active/dephosphorylated beta-catenin in lung fibroblasts, and in COL1A1 mRNA levels and collagen release into culture medium induced by alpha-defensin-1 and alpha-defensin-2.	Quercetin	55-64	collagen type I alpha 1 chain	Homo sapiens	214-220
19017364-12	2009	These findings indicate that combinational administration of flavonoids capable of suppressing HSP70 and GRP78 such as quercetin and EGCG might represent a novel approach for cancer therapy or chemoprevention.	Quercetin	119-128	heat shock protein family A (Hsp70) member 5	Homo sapiens	105-110
19651184-5	2009	Quercetin treatment also caused a measurable increase in the mRNA expression of human 8-oxoguanine DNA glycosylase (hOGG1) at 0 and 4h after H2O2 treatment (measured using RT-PCR).	Quercetin	0-9	8-oxoguanine DNA glycosylase	Homo sapiens	86-114
19651184-5	2009	Quercetin treatment also caused a measurable increase in the mRNA expression of human 8-oxoguanine DNA glycosylase (hOGG1) at 0 and 4h after H2O2 treatment (measured using RT-PCR).	Quercetin	0-9	8-oxoguanine DNA glycosylase	Homo sapiens	116-121
19651184-6	2009	In addition, the highest level of quercetin tested (100 microM) maintained hOGG1 expression at basal levels or higher for up to 12h after H2O2 treatment, while oxidant treatment alone resulted in significant reduction of hOGG1 at 8h.	Quercetin	34-43	8-oxoguanine DNA glycosylase	Homo sapiens	75-80
19651184-6	2009	In addition, the highest level of quercetin tested (100 microM) maintained hOGG1 expression at basal levels or higher for up to 12h after H2O2 treatment, while oxidant treatment alone resulted in significant reduction of hOGG1 at 8h.	Quercetin	34-43	8-oxoguanine DNA glycosylase	Homo sapiens	221-226
19017364-2	2009	The bioflavonoid quercetin inhibits HSP70 expression and induces cancer cells apoptosis.	Quercetin	17-26	heat shock protein family A (Hsp70) member 4	Homo sapiens	36-41
19744476-7	2009	A significant decrease in total antioxidant levels and super oxide dismutase, glutathione peroxidase and catalase levels was seen in the hypothalamus after stress and treatment with quercetin significantly increased these oxidative parameters and there was a significant decrease in lipid hydroperoxide levels.	Quercetin	182-191	catalase	Rattus norvegicus	105-113
19017364-3	2009	In the present study, we have investigated the effects of HSP70 down-regulation on the unfolded protein response (UPR) and addressed a novel strategy to enhance the proapoptotic effect of quercetin by suppressing GRP78 induction simultaneously.	Quercetin	188-197	heat shock protein family A (Hsp70) member 5	Homo sapiens	213-218
19017364-4	2009	Treatment of human breast cancer cells with quercetin down-regulates HSP70 expression, but up-regulates GRP78 expression in a dose-dependent manner.	Quercetin	44-53	heat shock protein family A (Hsp70) member 4	Homo sapiens	69-74
19017364-4	2009	Treatment of human breast cancer cells with quercetin down-regulates HSP70 expression, but up-regulates GRP78 expression in a dose-dependent manner.	Quercetin	44-53	heat shock protein family A (Hsp70) member 5	Homo sapiens	104-109
19017364-6	2009	Moreover, our studies reveal that HSP70 knockdown or quercetin induces other typical components of the UPR, including CHOP expression, eIF2alpha and JNK phosphorylation, caspases activation and XBP-1 splicing.	Quercetin	53-62	DNA damage inducible transcript 3	Homo sapiens	118-122
19017364-6	2009	Moreover, our studies reveal that HSP70 knockdown or quercetin induces other typical components of the UPR, including CHOP expression, eIF2alpha and JNK phosphorylation, caspases activation and XBP-1 splicing.	Quercetin	53-62	eukaryotic translation initiation factor 2A	Homo sapiens	135-144
19017364-6	2009	Moreover, our studies reveal that HSP70 knockdown or quercetin induces other typical components of the UPR, including CHOP expression, eIF2alpha and JNK phosphorylation, caspases activation and XBP-1 splicing.	Quercetin	53-62	mitogen-activated protein kinase 8	Homo sapiens	149-152
19017364-6	2009	Moreover, our studies reveal that HSP70 knockdown or quercetin induces other typical components of the UPR, including CHOP expression, eIF2alpha and JNK phosphorylation, caspases activation and XBP-1 splicing.	Quercetin	53-62	X-box binding protein 1	Homo sapiens	194-199
19017364-7	2009	Abrogating the induction of pro-survival chaperone GRP78 by small interfering RNA sensitizes breast cancer cells to quercetin.	Quercetin	116-125	heat shock protein family A (Hsp70) member 5	Homo sapiens	51-56
19017364-8	2009	Colony survival assays demonstrate that treatment of breast cancer cells with green tea (-)-epigallocatechin gallate (EGCG), which binds to the ATP-binding domain of GRP78 and blocks its protective function, synergistically promoted quercetin-induced cell death.	Quercetin	233-242	heat shock protein family A (Hsp70) member 5	Homo sapiens	166-171
19017364-10	2009	The pro-survival GRP78 induction contributes to quercetin resistance.	Quercetin	48-57	heat shock protein family A (Hsp70) member 5	Homo sapiens	17-22
19017364-11	2009	Abrogation of GRP78 induction or inhibition of GRP78 activity increases the effectiveness of quercetin.	Quercetin	93-102	heat shock protein family A (Hsp70) member 5	Homo sapiens	14-19
19017364-11	2009	Abrogation of GRP78 induction or inhibition of GRP78 activity increases the effectiveness of quercetin.	Quercetin	93-102	heat shock protein family A (Hsp70) member 5	Homo sapiens	47-52
19017364-12	2009	These findings indicate that combinational administration of flavonoids capable of suppressing HSP70 and GRP78 such as quercetin and EGCG might represent a novel approach for cancer therapy or chemoprevention.	Quercetin	119-128	heat shock protein family A (Hsp70) member 4	Homo sapiens	95-100
19933203-5	2009	Overexpression of each of the three genes in the absence of N/NO(3)(-) strongly suppresses the key regulators of anthocyanin synthesis PAP1 and PAP2, genes in the anthocyanin-specific part of flavonoid synthesis, as well as cyanidin- but not quercetin- or kaempferol-glycoside production.	Quercetin	242-251	phosphatidic acid phosphatase 1	Arabidopsis thaliana	135-139
19933203-5	2009	Overexpression of each of the three genes in the absence of N/NO(3)(-) strongly suppresses the key regulators of anthocyanin synthesis PAP1 and PAP2, genes in the anthocyanin-specific part of flavonoid synthesis, as well as cyanidin- but not quercetin- or kaempferol-glycoside production.	Quercetin	242-251	Purple acid phosphatases superfamily protein	Arabidopsis thaliana	144-148
19826085-6	2009	Conversely, the addition of quercetin, a flavonoidal MCT1 inhibitor, markedly reduces the apparent rate of pyruvate-to-lactate conversion.	Quercetin	28-37	solute carrier family 16 member 1	Homo sapiens	53-57
19903372-7	2009	Quercetin was absorbed by passive diffusion and a pH-dependent mechanism mediated by the organic anion transporting protein B (OATP-B).	Quercetin	0-9	solute carrier organic anion transporter family member 2B1	Homo sapiens	89-125
19903372-7	2009	Quercetin was absorbed by passive diffusion and a pH-dependent mechanism mediated by the organic anion transporting protein B (OATP-B).	Quercetin	0-9	solute carrier organic anion transporter family member 2B1	Homo sapiens	127-133
19596285-3	2009	The in vitro results showed that quercetin and macluraxanthone displayed a concentration-dependant inhibition of AChE and BChE.	Quercetin	33-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
19596285-3	2009	The in vitro results showed that quercetin and macluraxanthone displayed a concentration-dependant inhibition of AChE and BChE.	Quercetin	33-42	butyrylcholinesterase	Homo sapiens	122-126
19450372-10	2009	Pure polyphenols, particularly quercetin, also reduced NADPH oxidase subunit expression, especially p47phox, in all cell types tested.	Quercetin	31-40	neutrophil cytosolic factor 1	Homo sapiens	100-107
20092751-4	2009	The second part of PBMCs was divided into group A, B and C. Group A and B were pretreated with HSP70 blocker (Quercetin) for 1.0 h, then were stimulated by LPS for 4.0 h. Cells and supernatants were also collected.	Quercetin	110-119	heat shock protein family A (Hsp70) member 4	Homo sapiens	95-100
20092751-6	2009	In this experiment, the effect of Quercetin on TNF-alpha, IL-10 and HSP70 expression in human PBMCs was assessed.	Quercetin	34-43	tumor necrosis factor	Homo sapiens	47-56
20092751-6	2009	In this experiment, the effect of Quercetin on TNF-alpha, IL-10 and HSP70 expression in human PBMCs was assessed.	Quercetin	34-43	interleukin 10	Homo sapiens	58-63
20092751-6	2009	In this experiment, the effect of Quercetin on TNF-alpha, IL-10 and HSP70 expression in human PBMCs was assessed.	Quercetin	34-43	heat shock protein family A (Hsp70) member 4	Homo sapiens	68-73
20092751-8	2009	The expression level of HSP70 was significantly decreased, however, the expression of TNF-alpha and IL-10 was enhanced in Quercetin group (P &lt; 0.05).	Quercetin	122-131	heat shock protein family A (Hsp70) member 4	Homo sapiens	24-29
20092751-8	2009	The expression level of HSP70 was significantly decreased, however, the expression of TNF-alpha and IL-10 was enhanced in Quercetin group (P &lt; 0.05).	Quercetin	122-131	tumor necrosis factor	Homo sapiens	86-95
20092751-8	2009	The expression level of HSP70 was significantly decreased, however, the expression of TNF-alpha and IL-10 was enhanced in Quercetin group (P &lt; 0.05).	Quercetin	122-131	interleukin 10	Homo sapiens	100-105
19641096-7	2009	Kir current in MgATP-loaded cells was partially inhibited by bath application of quercetin (100 microM), phenylarsine oxide (100 microM), or wortmannin (50 microM), inhibitors of phosphatidylinositol (PI) kinases, and was completely inhibited by cell dialysis with 2 mM adenosine, a PI4 kinase inhibitor.	Quercetin	81-90	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	0-3
19043800-0	2009	Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.	Quercetin	0-9	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	80-85
19043800-0	2009	Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.	Quercetin	0-9	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	87-92
19043800-0	2009	Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.	Quercetin	0-9	Dual specificity mitogen-activated protein kinase kinase sek-1	Caenorhabditis elegans	94-99
19043800-0	2009	Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.	Quercetin	0-9	CaMKII_AD domain-containing protein;Calcium/calmodulin-dependent protein kinase;Calcium/calmodulin-dependent protein kinase type II	Caenorhabditis elegans	104-110
19043800-7	2009	However, four genes were pinpointed to be required for the quercetin derived lifespan extension, namely age-1, daf-2, unc-43 and sek-1.	Quercetin	59-68	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	104-109
19043800-7	2009	However, four genes were pinpointed to be required for the quercetin derived lifespan extension, namely age-1, daf-2, unc-43 and sek-1.	Quercetin	59-68	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	111-116
19043800-7	2009	However, four genes were pinpointed to be required for the quercetin derived lifespan extension, namely age-1, daf-2, unc-43 and sek-1.	Quercetin	59-68	CaMKII_AD domain-containing protein;Calcium/calmodulin-dependent protein kinase;Calcium/calmodulin-dependent protein kinase type II	Caenorhabditis elegans	118-124
19043800-7	2009	However, four genes were pinpointed to be required for the quercetin derived lifespan extension, namely age-1, daf-2, unc-43 and sek-1.	Quercetin	59-68	Dual specificity mitogen-activated protein kinase kinase sek-1	Caenorhabditis elegans	129-134
19794518-7	2009	In contrast, quercetin increased CYP1B1 and CYP1A1 gene expression and activated AhR, whereas kaempferol and isorhamnetin suppressed constitutive CYP1B1 expression and antagonized AhR activation by benzo[a]pyrene.	Quercetin	13-22	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	33-39
19390785-0	2009	Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells.	Quercetin	55-64	heme oxygenase 1	Rattus norvegicus	0-16
19390785-1	2009	OBJECTIVE AND DESIGN: We investigated the involvement of heme oxygenase (HO)-1 in the anti-allergic action of quercetin against degranulation of rat basophilic leukemia (RBL-2H3) cells, rat peritoneal mast cells, and mouse bone marrow-derived mast cells.	Quercetin	110-119	heme oxygenase 1	Rattus norvegicus	57-78
19390785-6	2009	HO-1 metabolites, bilirubin and CO, led to inhibit degranulation, and quercetin translocated Nrf2 from cytoplasm into nucleus in RBL-2H3 cells.	Quercetin	70-79	NFE2 like bZIP transcription factor 2	Rattus norvegicus	93-97
19390785-7	2009	CONCLUSION: These results strongly suggest that quercetin exerted anti-allergic actions via activation of Nrf2-HO-1 pathway.	Quercetin	48-57	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-110
19818314-5	2009	AMPK is a serine/threonine protein kinase and is activated by several natural compounds, including resveratrol, epigallocatechin gallate, berberine, and quercetin.	Quercetin	153-162	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
19865538-0	2009	Effect of quercetin on paraoxonase 2 levels in RAW264.7 macrophages and in human monocytes--role of quercetin metabolism.	Quercetin	10-19	paraoxonase 2	Homo sapiens	23-36
19865538-3	2009	In the present study we determined the effect of quercetin on paraoxonase 2 levels in cultured murine macrophages in vitro and in overweight subjects with a high cardiovascular risk phenotype supplemented with 150 mg quercetin/day for 42 days in vivo.	Quercetin	49-58	paraoxonase 2	Mus musculus	62-75
19865538-4	2009	Supplementation of murine RAW264.7 macrophages in culture with increasing concentrations of quercetin (1, 10, 20 micromol/L) resulted in a significant increase in PON2 mRNA and protein levels, as compared to untreated controls.	Quercetin	92-101	paraoxonase 2	Mus musculus	163-167
19865538-6	2009	However the methylated quercetin derivative isorhamnetin enhanced PON2 gene expression in RAW264.7 cells to similar extent like quercetin.	Quercetin	23-32	paraoxonase 2	Mus musculus	66-70
19865538-8	2009	Current data indicate that quercetin supplementation increases PON2 levels in cultured monocytes in vitro but not in human volunteers in vivo.	Quercetin	27-36	paraoxonase 2	Homo sapiens	63-67
19576171-0	2009	Essential role of Nrf2 in keratinocyte protection from UVA by quercetin.	Quercetin	62-71	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
19576171-4	2009	Quercetin pretreatment strongly suppressed UVA-induced apoptosis in human keratinocyte HaCaT cells, markedly increased protein levels of the transcription factor Nrf2, induced the expression of antioxidative genes, and dramatically reduced the production of reactive oxygen species following UVA irradiation.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	162-166
19576171-6	2009	Thus, quercetin protects cells from UVA damage mainly by elevating intracellular antioxidative activity via the enhanced accumulation of a transcription factor for antioxidant genes, Nrf2.	Quercetin	6-15	NFE2 like bZIP transcription factor 2	Homo sapiens	183-187
19734664-3	2009	The results reveal that quercetin, but not 4Bn-Q, inhibited cell proliferation and induced apoptosis as characterized by DNA fragmentation, activation of caspase-3, and PARP cleavage.	Quercetin	24-33	caspase 3	Homo sapiens	154-163
19734664-3	2009	The results reveal that quercetin, but not 4Bn-Q, inhibited cell proliferation and induced apoptosis as characterized by DNA fragmentation, activation of caspase-3, and PARP cleavage.	Quercetin	24-33	poly(ADP-ribose) polymerase 1	Homo sapiens	169-173
19464278-0	2009	Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells.	Quercetin	74-83	amyloid beta precursor protein	Homo sapiens	109-129
19464278-4	2009	Both quercetin and ginkgolide B may be involved in the inhibitory effects of EGb761 on JNK, ERK1/2 and Akt signaling pathways.	Quercetin	5-14	mitogen-activated protein kinase 8	Homo sapiens	87-90
19464278-4	2009	Both quercetin and ginkgolide B may be involved in the inhibitory effects of EGb761 on JNK, ERK1/2 and Akt signaling pathways.	Quercetin	5-14	mitogen-activated protein kinase 3	Homo sapiens	92-98
19464278-8	2009	Both quercetin and ginkgolide B may be involved in the PAF antagonist activity of EGb761.	Quercetin	5-14	PCNA clamp associated factor	Homo sapiens	55-58
19734679-4	2009	Quercetin decreased the intracellular tyrosinase activity as well as the tyrosinase activity in a cell culture-free system.	Quercetin	0-9	tyrosinase	Mus musculus	38-48
19734679-4	2009	Quercetin decreased the intracellular tyrosinase activity as well as the tyrosinase activity in a cell culture-free system.	Quercetin	0-9	tyrosinase	Mus musculus	73-83
19734679-5	2009	We also examined the cellular level of tyrosinase protein and found that quercetin dose-dependently inhibited tyrosinase protein expression.	Quercetin	73-82	tyrosinase	Mus musculus	39-49
19734679-5	2009	We also examined the cellular level of tyrosinase protein and found that quercetin dose-dependently inhibited tyrosinase protein expression.	Quercetin	73-82	tyrosinase	Mus musculus	110-120
19734679-6	2009	We consider from these results that the inhibition of melanogenesis by quercetin was due to the inhibition of both tyrosinase activity and of the protein expression.	Quercetin	71-80	tyrosinase	Mus musculus	115-125
19496785-4	2009	Low doses of resveratrol (10 microM) or quercetin (25 microM) separately had no effect on apoptosis induction, but had a strong effect on caspase 3/7 activation when administered together.	Quercetin	40-49	caspase 3	Rattus norvegicus	138-147
19794518-7	2009	In contrast, quercetin increased CYP1B1 and CYP1A1 gene expression and activated AhR, whereas kaempferol and isorhamnetin suppressed constitutive CYP1B1 expression and antagonized AhR activation by benzo[a]pyrene.	Quercetin	13-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	44-50
19496785-5	2009	Western blot analyses showed that resveratrol (10 microM) and quercetin (25 microM) caused a reduction in phosphorylation of Akt, but this reduction was not sufficient by itself to mediate the effects of these polyphenols.	Quercetin	62-71	AKT serine/threonine kinase 1	Rattus norvegicus	125-128
19794518-7	2009	In contrast, quercetin increased CYP1B1 and CYP1A1 gene expression and activated AhR, whereas kaempferol and isorhamnetin suppressed constitutive CYP1B1 expression and antagonized AhR activation by benzo[a]pyrene.	Quercetin	13-22	aryl hydrocarbon receptor	Homo sapiens	81-84
19344998-0	2009	Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.	Quercetin	10-19	KRAS proto-oncogene, GTPase	Homo sapiens	110-114
19712257-9	2009	Statistical data from immunohistochemistry and western blot results showed that heat shock protein expression was enhanced in the glutamine group compared with that in the control group (P &lt; 0.01), while it was weaker in the quercetin plus glutamine group and quercetin plus saline group than that in the control group (P &lt; 0.01).	Quercetin	263-272	selenoprotein K	Rattus norvegicus	80-98
19877526-0	2009	[Effect of proliferation, c-met and vascular endothelial growth factor expression in the Eca109/9706 cells by liposomal quercetin].	Quercetin	120-129	vascular endothelial growth factor A	Homo sapiens	36-70
19877526-1	2009	OBJECTIVE: To explore the effect of cell proliferation, c-met and vascular endothelial growth factor (VEGF) expression by liposomal quercetin in the Eca109/9706 cells induced by liposomal quercetin.	Quercetin	132-141	vascular endothelial growth factor A	Homo sapiens	66-100
19877526-1	2009	OBJECTIVE: To explore the effect of cell proliferation, c-met and vascular endothelial growth factor (VEGF) expression by liposomal quercetin in the Eca109/9706 cells induced by liposomal quercetin.	Quercetin	132-141	vascular endothelial growth factor A	Homo sapiens	102-106
19877526-1	2009	OBJECTIVE: To explore the effect of cell proliferation, c-met and vascular endothelial growth factor (VEGF) expression by liposomal quercetin in the Eca109/9706 cells induced by liposomal quercetin.	Quercetin	188-197	vascular endothelial growth factor A	Homo sapiens	66-100
19877526-1	2009	OBJECTIVE: To explore the effect of cell proliferation, c-met and vascular endothelial growth factor (VEGF) expression by liposomal quercetin in the Eca109/9706 cells induced by liposomal quercetin.	Quercetin	188-197	vascular endothelial growth factor A	Homo sapiens	102-106
19877526-3	2009	After 48-hour-exposure to liposomal quercetin, the expression and cellular localization of c-met and VEGF in Eca109/9706 cells were examined by using immunohistochemistry assay and Western blotting.	Quercetin	36-45	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	91-96
19877526-8	2009	CONCLUSION: The liposomal quercetin could suppress the proliferation of culture Eca109/9706 cells, which was about to be related with the suppression high expression of c-met and VEGF.	Quercetin	26-35	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	169-174
19877526-8	2009	CONCLUSION: The liposomal quercetin could suppress the proliferation of culture Eca109/9706 cells, which was about to be related with the suppression high expression of c-met and VEGF.	Quercetin	26-35	vascular endothelial growth factor A	Homo sapiens	179-183
21784011-10	2009	In addition, results from Western blot showed that GGA-induced Hsp70 expression of neurons both in normal and heat-treatment conditions (P&lt;0.01, P&lt;0.05) and quercetin inhibited GGA-induced Hsp70 expression (P&lt;0.05).	Quercetin	163-172	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	195-200
21784011-12	2009	Quercetin inhibited GGA-induced Hsp70 expression and prevented GGA-protective effects, which indicated that this protection was dependent on the Hsp70 synthesis.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	32-37
21784011-12	2009	Quercetin inhibited GGA-induced Hsp70 expression and prevented GGA-protective effects, which indicated that this protection was dependent on the Hsp70 synthesis.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	145-150
18982426-0	2009	Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	19-28
18982426-0	2009	Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways.	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	37-43
18982426-0	2009	Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	106-110
18982426-4	2009	However, the mechanisms regulating ICAM-1 expression by quercetin in human A549 cells were still unclear.	Quercetin	56-65	intercellular adhesion molecule 1	Homo sapiens	35-41
18982426-5	2009	In this study, the inhibitory effect of quercetin on ICAM-1 expression by interleukin-1 beta (IL-1 beta)-stimulated A549 cells was investigated, and the roles of mitogen-activated protein kinases (MAPK) pathways were explored.	Quercetin	40-49	intercellular adhesion molecule 1	Homo sapiens	53-59
18982426-5	2009	In this study, the inhibitory effect of quercetin on ICAM-1 expression by interleukin-1 beta (IL-1 beta)-stimulated A549 cells was investigated, and the roles of mitogen-activated protein kinases (MAPK) pathways were explored.	Quercetin	40-49	interleukin 1 beta	Homo sapiens	74-92
19344998-0	2009	Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.	Quercetin	10-19	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	119-123
18982426-5	2009	In this study, the inhibitory effect of quercetin on ICAM-1 expression by interleukin-1 beta (IL-1 beta)-stimulated A549 cells was investigated, and the roles of mitogen-activated protein kinases (MAPK) pathways were explored.	Quercetin	40-49	interleukin 1 beta	Homo sapiens	94-103
18982426-6	2009	Quercetin attenuated IL-1 beta-induced expression of ICAM-1 mRNA and protein in a dose-dependent manner.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	21-30
19481559-7	2009	In addition, cells subjected to DMPS exhibited significantly increased reactive oxygen species (ROS) generation, and ROS scavengers, such as quercetin and Tiron, but not N-acetylcysteine (NAC), inhibited DMPS-induced activations of caspase-8, -3 and subsequent apoptotic cell death, indicating the role of ROS in caspase-8-mediated apoptosis.	Quercetin	141-150	caspase 8	Homo sapiens	232-241
18982426-6	2009	Quercetin attenuated IL-1 beta-induced expression of ICAM-1 mRNA and protein in a dose-dependent manner.	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	53-59
18982426-7	2009	The experiment suggested that quercetin actively inhibited inhibitory protein of nuclear factor-kappa B (I kappa B) degradation, and nuclear factor-kappa B (NF-kappa B) activity.	Quercetin	30-39	nuclear factor kappa B subunit 1	Homo sapiens	81-103
18982426-7	2009	The experiment suggested that quercetin actively inhibited inhibitory protein of nuclear factor-kappa B (I kappa B) degradation, and nuclear factor-kappa B (NF-kappa B) activity.	Quercetin	30-39	nuclear factor kappa B subunit 1	Homo sapiens	157-167
18982426-10	2009	The inhibitory effect of quercetin on ICAM-1 expression was mediated by the sequential attenuation of the c-fos and c-jun mRNA expressions.	Quercetin	25-34	intercellular adhesion molecule 1	Homo sapiens	38-44
18982426-10	2009	The inhibitory effect of quercetin on ICAM-1 expression was mediated by the sequential attenuation of the c-fos and c-jun mRNA expressions.	Quercetin	25-34	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-111
18982426-10	2009	The inhibitory effect of quercetin on ICAM-1 expression was mediated by the sequential attenuation of the c-fos and c-jun mRNA expressions.	Quercetin	25-34	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121
18982426-12	2009	Taken together, these results suggest that quercetin negatively modulating ICAM-1 partly dependent on MAPK pathways.	Quercetin	43-52	intercellular adhesion molecule 1	Homo sapiens	75-81
18982426-12	2009	Taken together, these results suggest that quercetin negatively modulating ICAM-1 partly dependent on MAPK pathways.	Quercetin	43-52	mitogen-activated protein kinase 1	Homo sapiens	102-106
19481559-7	2009	In addition, cells subjected to DMPS exhibited significantly increased reactive oxygen species (ROS) generation, and ROS scavengers, such as quercetin and Tiron, but not N-acetylcysteine (NAC), inhibited DMPS-induced activations of caspase-8, -3 and subsequent apoptotic cell death, indicating the role of ROS in caspase-8-mediated apoptosis.	Quercetin	141-150	caspase 8	Homo sapiens	313-322
19617894-11	2009	CONCLUSION: These data show that the flavonols quercetin and kaempferol have higher anti-invasion potency and higher MMP-3 inhibitory activity than isoflavones genistein, genistin and daidzein.	Quercetin	47-56	matrix metallopeptidase 3	Homo sapiens	117-122
19215233-0	2009	Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers.	Quercetin	37-46	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-75
19617894-2	2009	In this study, flavonoids from vegetables and fruits, such as quercetin, kaempferol, genistein, genistin, and daidzein, were tested for their ability to modulate the secretion and activity of MMP-3 in the MDA-MB-231 breast cancer cell line.	Quercetin	62-71	matrix metallopeptidase 3	Homo sapiens	192-197
19617894-9	2009	Quercetin and kaempferol also reduced MMP-3 activity in a dose-dependent manner, with IC(50) values in the range of 30 micromol/L and 45 micromol/L, respectively.	Quercetin	0-9	matrix metallopeptidase 3	Homo sapiens	38-43
19215233-0	2009	Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers.	Quercetin	37-46	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	77-83
19215233-3	2009	The aim of the present study was to investigate the effects of quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase (NAT2) and xanthine oxidase (XO) activity in healthy volunteers using caffeine as a probe drug.	Quercetin	63-72	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-101
19215233-3	2009	The aim of the present study was to investigate the effects of quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase (NAT2) and xanthine oxidase (XO) activity in healthy volunteers using caffeine as a probe drug.	Quercetin	63-72	N-acetyltransferase 2	Homo sapiens	132-136
19215233-16	2009	The results of the present study indicate that quercetin inhibits CYP1A2 function, but enhances CYP2A6, NAT2 and XO activity.	Quercetin	47-56	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	66-72
19215233-16	2009	The results of the present study indicate that quercetin inhibits CYP1A2 function, but enhances CYP2A6, NAT2 and XO activity.	Quercetin	47-56	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	96-102
19215233-16	2009	The results of the present study indicate that quercetin inhibits CYP1A2 function, but enhances CYP2A6, NAT2 and XO activity.	Quercetin	47-56	N-acetyltransferase 2	Homo sapiens	104-108
19215233-18	2009	Thus, we conclude that quercetin affects CYP1A2, CYP2A6, NAT2 and XO activity in vivo.	Quercetin	23-32	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	41-47
19215233-18	2009	Thus, we conclude that quercetin affects CYP1A2, CYP2A6, NAT2 and XO activity in vivo.	Quercetin	23-32	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	49-55
19215233-18	2009	Thus, we conclude that quercetin affects CYP1A2, CYP2A6, NAT2 and XO activity in vivo.	Quercetin	23-32	N-acetyltransferase 2	Homo sapiens	57-61
19652885-0	2009	Interactions of gallic acid, resveratrol, quercetin and aspirin at the platelet cyclooxygenase-1 level.	Quercetin	42-51	prostaglandin-endoperoxide synthase 1	Mus musculus	80-96
19664387-0	2009	[Effects of quercetin on the expression of VEGF-C and VEGFR-3 in human cancer MGC-803 cells].	Quercetin	12-21	vascular endothelial growth factor C	Homo sapiens	43-49
19755441-0	2009	Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells.	Quercetin	0-9	caspase 3	Homo sapiens	41-69
19755441-7	2009	Quercetin treatment promoted activation of caspase-3, -8 and -9 in MDA-MB-231 cells.	Quercetin	0-9	caspase 3	Homo sapiens	43-63
19755441-8	2009	Caspase inhibitors prevented the quercetin-induced loss of cell viability.	Quercetin	33-42	caspase 8	Homo sapiens	0-7
19755441-9	2009	Quercetin increased abundance of the pro-apoptotic protein Bax and decreased the levels of anti-apoptotic protein Bcl-2.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	59-62
19755441-9	2009	Quercetin increased abundance of the pro-apoptotic protein Bax and decreased the levels of anti-apoptotic protein Bcl-2.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	114-119
19755441-11	2009	Taken together, these findings suggest that quercetin results in human breast cancer MDA-MB-231 cell death through mitochondrial- and caspase-3-dependent pathways.	Quercetin	44-53	caspase 3	Homo sapiens	115-143
19664387-0	2009	[Effects of quercetin on the expression of VEGF-C and VEGFR-3 in human cancer MGC-803 cells].	Quercetin	12-21	fms related receptor tyrosine kinase 4	Homo sapiens	54-61
19623560-0	2009	Regulation of survivin and Bcl-2 in HepG2 cell apoptosis induced by quercetin.	Quercetin	68-77	BCL2 apoptosis regulator	Homo sapiens	27-32
19707521-1	2009	Three major flavonoid chamomile components (quercetin, apigenin-7-O-glucoside and rutin) were subjected to oxidative metabolism by cytochrome P-450 of rat liver microsomal preparations.	Quercetin	44-53	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	131-147
19565472-3	2009	The results revealed that 4Ac-Q and quercetin, but not 4Me-Q, significantly inhibit cell proliferation by caspase-mediated apoptosis when characterized by DNA fragmentation, activation of caspase-3 and PARP cleavage while 4Me-Q lost this ability.	Quercetin	36-45	caspase 3	Homo sapiens	188-197
19565472-3	2009	The results revealed that 4Ac-Q and quercetin, but not 4Me-Q, significantly inhibit cell proliferation by caspase-mediated apoptosis when characterized by DNA fragmentation, activation of caspase-3 and PARP cleavage while 4Me-Q lost this ability.	Quercetin	36-45	poly(ADP-ribose) polymerase 1	Homo sapiens	202-206
19440933-0	2009	Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway.	Quercetin	0-9	cyclin D1	Homo sapiens	84-93
19440933-0	2009	Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway.	Quercetin	0-9	catenin beta 1	Homo sapiens	130-142
19440933-2	2009	The aim of this study was to investigate the effects of quercetin on the growth of the colon carcinoma cell line and the regulation effect of quercetin on the Wnt/beta-catenin signaling pathway.	Quercetin	142-151	catenin beta 1	Homo sapiens	163-175
19440933-5	2009	Effects of quercetin on mRNA expression of cyclin D(1) and survivin were detected by semiquantitative RT-PCR.	Quercetin	11-20	cyclin D1	Homo sapiens	43-54
19440933-8	2009	The regulation effect of quercetin on the Wnt/beta-catenin signaling transcription was investigated by using this reporter gene model.	Quercetin	25-34	catenin beta 1	Homo sapiens	46-58
19440933-13	2009	Quercetin downregulated transcriptional activity of beta-catenin/Tcf in SW480 cells transiently transfected with the TCF-4 reporter gene.	Quercetin	0-9	catenin beta 1	Homo sapiens	52-64
19440933-13	2009	Quercetin downregulated transcriptional activity of beta-catenin/Tcf in SW480 cells transiently transfected with the TCF-4 reporter gene.	Quercetin	0-9	hepatocyte nuclear factor 4 alpha	Homo sapiens	65-68
19440933-13	2009	Quercetin downregulated transcriptional activity of beta-catenin/Tcf in SW480 cells transiently transfected with the TCF-4 reporter gene.	Quercetin	0-9	transcription factor 4	Homo sapiens	117-122
19440933-14	2009	Within 24 hours of treatment, a 160-mumol/L concentration of quercetin reduced beta-catenin/Tcf transcriptional activity by about 18-fold.	Quercetin	61-70	catenin beta 1	Homo sapiens	79-91
19440933-14	2009	Within 24 hours of treatment, a 160-mumol/L concentration of quercetin reduced beta-catenin/Tcf transcriptional activity by about 18-fold.	Quercetin	61-70	hepatocyte nuclear factor 4 alpha	Homo sapiens	92-95
19440933-15	2009	Cyclin D(1) and the survivin gene were downregulated markedly by quercetin in a dose-dependent manner at both the transcription and protein expression levels.	Quercetin	65-74	cyclin D1	Homo sapiens	0-11
19440933-16	2009	CONCLUSION: The results indicate that the molecular mechanism underlying the antitumor effect of quercetin in SW480 colon cancer cells is related to the inhibition of expression of cyclin D(1) and survivin as well as the Wnt/beta-catenin signaling pathway.	Quercetin	97-106	cyclin D1	Homo sapiens	181-192
19440933-16	2009	CONCLUSION: The results indicate that the molecular mechanism underlying the antitumor effect of quercetin in SW480 colon cancer cells is related to the inhibition of expression of cyclin D(1) and survivin as well as the Wnt/beta-catenin signaling pathway.	Quercetin	97-106	catenin beta 1	Homo sapiens	225-237
19623560-2	2009	However, the regulation of survivin and Bcl-2 on the quercetin-induced cell-growth inhibition and apoptosis in cancer cells remains unclear.	Quercetin	53-62	BCL2 apoptosis regulator	Homo sapiens	40-45
19623560-6	2009	We also demonstrate that the levels of survivin and Bcl-2 protein expression in HepG2 cells decreased concurrently, and the levels of p53 protein increased significantly after treatment with quercetin by immunocytochemistry analysis.	Quercetin	191-200	tumor protein p53	Homo sapiens	134-137
19623560-8	2009	These data clearly indicate that quercetin-induced apoptosis is associated with caspase activation, and the levels of survivin and Bcl-2.	Quercetin	33-42	BCL2 apoptosis regulator	Homo sapiens	131-136
19623560-10	2009	Together, concurrent down-regulated survivin and Bcl-2 play an important role in HepG2 cell apoptosis induced by quercetin.	Quercetin	113-122	BCL2 apoptosis regulator	Homo sapiens	49-54
19375450-8	2009	Interestingly, resveratrol and piceatannol inhibited both ATPase and ATP synthesis whereas quercetin, quercetrin or quercetin-3-beta-d glucoside inhibited only ATPase activity and not ATP synthesis.	Quercetin	91-100	ATPase	Escherichia coli	160-166
19401153-0	2009	Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin.	Quercetin	165-174	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	14-43
19401153-0	2009	Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin.	Quercetin	165-174	tumor necrosis factor	Homo sapiens	60-87
19496084-6	2009	Gene set enrichment analysis (GSEA) and quantitative RT-PCR analysis showed that the quercetin diets had greatest suppressive effect on the STZ-induced elevation of expression of cyclin-dependent kinase inhibitor p21(WAF1/Cip1) (Cdkn1a).	Quercetin	85-94	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	213-227
19401153-0	2009	Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin.	Quercetin	165-174	matrix metallopeptidase 9	Homo sapiens	112-138
19401153-4	2009	Red wine extract (RWE) and quercetin, which is a major flavonoid present in red wine, inhibited significantly the TNF-alpha-induced upregulation of MMP-9 and cell migration, whereas resveratrol did not have significant inhibitory effects.	Quercetin	27-36	tumor necrosis factor	Homo sapiens	114-123
19401153-4	2009	Red wine extract (RWE) and quercetin, which is a major flavonoid present in red wine, inhibited significantly the TNF-alpha-induced upregulation of MMP-9 and cell migration, whereas resveratrol did not have significant inhibitory effects.	Quercetin	27-36	matrix metallopeptidase 9	Homo sapiens	148-153
19401153-5	2009	The inhibitory effects of RWE and quercetin were mediated by suppression of the phosphorylation of Akt and the transactivation of activator protein-1 and nuclear factor-kappaB, as determined by Western blotting and luciferase assays, respectively.	Quercetin	34-43	AKT serine/threonine kinase 1	Homo sapiens	99-102
19401153-5	2009	The inhibitory effects of RWE and quercetin were mediated by suppression of the phosphorylation of Akt and the transactivation of activator protein-1 and nuclear factor-kappaB, as determined by Western blotting and luciferase assays, respectively.	Quercetin	34-43	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-175
19401153-7	2009	Direct kinase assay data revealed that RWE and quercetin inhibited phosphatidylinositol 3-kinase (PI3K) activity.	Quercetin	47-56	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	67-96
19494027-8	2009	Quercetin also ameliorated liver injury and reduced the expression of hepatic endothelin-1 and HO-1 in untreated cirrhotic rats.	Quercetin	0-9	endothelin 1	Rattus norvegicus	78-90
19494027-8	2009	Quercetin also ameliorated liver injury and reduced the expression of hepatic endothelin-1 and HO-1 in untreated cirrhotic rats.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	95-99
19496084-6	2009	Gene set enrichment analysis (GSEA) and quantitative RT-PCR analysis showed that the quercetin diets had greatest suppressive effect on the STZ-induced elevation of expression of cyclin-dependent kinase inhibitor p21(WAF1/Cip1) (Cdkn1a).	Quercetin	85-94	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	229-235
19496084-7	2009	Quercetin also suppressed STZ-induced expression of Cdkn1a in the pancreas.	Quercetin	0-9	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	52-58
19496084-8	2009	Dietary quercetin might improve liver and pancreas functions by enabling the recovery of cell proliferation through the inhibition of Cdkn1a expression.	Quercetin	8-17	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	134-140
19496084-9	2009	Unexpectedly, in healthy control mice the 0.5 and 1% quercetin diets reduced the expression of ubiquitin C (Ubc), which has heat-shock element (HSE) in the promoter region, in the liver.	Quercetin	53-62	ubiquitin C	Mus musculus	95-106
19496084-9	2009	Unexpectedly, in healthy control mice the 0.5 and 1% quercetin diets reduced the expression of ubiquitin C (Ubc), which has heat-shock element (HSE) in the promoter region, in the liver.	Quercetin	53-62	ubiquitin C	Mus musculus	108-111
19764559-6	2009	The inhibition of HSP70 through quercetin induced up-regulation and delayed descent of HSP90.	Quercetin	32-41	heat shock protein family A (Hsp70) member 4	Homo sapiens	18-23
19764559-6	2009	The inhibition of HSP70 through quercetin induced up-regulation and delayed descent of HSP90.	Quercetin	32-41	heat shock protein 90 alpha family class A member 1	Homo sapiens	87-92
19297429-0	2009	Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells.	Quercetin	0-9	occludin	Homo sapiens	103-111
19191007-5	2009	RESULTS: The phosphorylation of HSP27 was induced by AngII and PDGF-BB in a time- and concentration-dependent manner in VSMCs, which was significantly blocked by the HSP inhibitor Quercetin in a concentration-dependent manner.	Quercetin	180-189	heat shock protein family B (small) member 1	Homo sapiens	32-37
19191007-5	2009	RESULTS: The phosphorylation of HSP27 was induced by AngII and PDGF-BB in a time- and concentration-dependent manner in VSMCs, which was significantly blocked by the HSP inhibitor Quercetin in a concentration-dependent manner.	Quercetin	180-189	angiotensinogen	Homo sapiens	53-58
19191007-6	2009	Reorganization of actin stimulated by AngII and PDGF-BB was markedly inhibited by pretreatment with 100 micromol/l Quercetin.	Quercetin	115-124	angiotensinogen	Homo sapiens	38-43
19191007-7	2009	The migration of VSMCs induced by AngII and PDGF-BB was partially inhibited by Quercetin with peak inhibition concentration at 100 micromol/l.	Quercetin	79-88	angiotensinogen	Homo sapiens	34-39
19325051-1	2009	It has been reported that naturally occurring quercetin exerts hepatoprotective effects through heme oxygenase-1 (HO-1) induction.	Quercetin	46-55	heme oxygenase 1	Homo sapiens	96-112
19325051-1	2009	It has been reported that naturally occurring quercetin exerts hepatoprotective effects through heme oxygenase-1 (HO-1) induction.	Quercetin	46-55	heme oxygenase 1	Homo sapiens	114-118
19325051-2	2009	However, the precise mechanism of how ethanol-associated liver damage is counteracted by quercetin-enhanced HO-1 metabolism still remains unclear.	Quercetin	89-98	heme oxygenase 1	Homo sapiens	108-112
19325051-9	2009	These results suggested that quercetin virtually attenuated ethanol-derived oxidative damage via HO-1 induction.	Quercetin	29-38	heme oxygenase 1	Homo sapiens	97-101
19578281-7	2009	The activities of extracellular signal-regulated kinase (ERK1/2), p38 MAP kinase, Akt and GSK-3beta were significantly increased with pressure overload and attenuated by quercetin treatment.	Quercetin	170-179	mitogen activated protein kinase 3	Rattus norvegicus	57-63
19578281-7	2009	The activities of extracellular signal-regulated kinase (ERK1/2), p38 MAP kinase, Akt and GSK-3beta were significantly increased with pressure overload and attenuated by quercetin treatment.	Quercetin	170-179	mitogen activated protein kinase 14	Rattus norvegicus	66-69
19578281-7	2009	The activities of extracellular signal-regulated kinase (ERK1/2), p38 MAP kinase, Akt and GSK-3beta were significantly increased with pressure overload and attenuated by quercetin treatment.	Quercetin	170-179	AKT serine/threonine kinase 1	Rattus norvegicus	82-85
19578281-7	2009	The activities of extracellular signal-regulated kinase (ERK1/2), p38 MAP kinase, Akt and GSK-3beta were significantly increased with pressure overload and attenuated by quercetin treatment.	Quercetin	170-179	glycogen synthase kinase 3 beta	Rattus norvegicus	90-99
19578281-8	2009	We conclude that quercetin appears to block the development of cardiac hypertrophy induced by pressure overload in rats and that these effects may be mediated through reduced oxidant status and inhibition of ERK1/2, p38 MAP kinase, Akt and GSK-3beta activities.	Quercetin	17-26	mitogen activated protein kinase 3	Rattus norvegicus	208-214
19578281-8	2009	We conclude that quercetin appears to block the development of cardiac hypertrophy induced by pressure overload in rats and that these effects may be mediated through reduced oxidant status and inhibition of ERK1/2, p38 MAP kinase, Akt and GSK-3beta activities.	Quercetin	17-26	mitogen activated protein kinase 14	Rattus norvegicus	216-219
19578281-8	2009	We conclude that quercetin appears to block the development of cardiac hypertrophy induced by pressure overload in rats and that these effects may be mediated through reduced oxidant status and inhibition of ERK1/2, p38 MAP kinase, Akt and GSK-3beta activities.	Quercetin	17-26	AKT serine/threonine kinase 1	Rattus norvegicus	232-235
19578281-8	2009	We conclude that quercetin appears to block the development of cardiac hypertrophy induced by pressure overload in rats and that these effects may be mediated through reduced oxidant status and inhibition of ERK1/2, p38 MAP kinase, Akt and GSK-3beta activities.	Quercetin	17-26	glycogen synthase kinase 3 beta	Rattus norvegicus	240-249
19470239-2	2009	In this study, we demonstrated that several flavonoids, including kaempferol, quercetin, fisetin, and chrysin block TNF-alpha induced IL-8 promoter activation and gene expression in HEK 293 cells.	Quercetin	78-87	tumor necrosis factor	Homo sapiens	116-125
19470239-2	2009	In this study, we demonstrated that several flavonoids, including kaempferol, quercetin, fisetin, and chrysin block TNF-alpha induced IL-8 promoter activation and gene expression in HEK 293 cells.	Quercetin	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
18986596-1	2009	The aim of this study was to determine the effect of dietary quercetin supplementation on blood lipids and TNF-alpha levels according to the apoE genotype in apoE3 and apoE4 targeted gene replacement mice.	Quercetin	61-70	tumor necrosis factor	Mus musculus	107-116
18986596-1	2009	The aim of this study was to determine the effect of dietary quercetin supplementation on blood lipids and TNF-alpha levels according to the apoE genotype in apoE3 and apoE4 targeted gene replacement mice.	Quercetin	61-70	apolipoprotein E	Mus musculus	141-145
18986596-6	2009	In mice receiving the basal diet without quercetin supplementation, levels of TNF-alpha in whole blood stimulated ex vivo with lipopolysaccharide were higher in apoE3 as compared to apoE4 transgenic mice.	Quercetin	41-50	tumor necrosis factor	Mus musculus	78-87
18986596-7	2009	Dietary quercetin significantly lowered levels of TNF-alpha by 44 % in apoE3 mice relative to apoE3 mice receiving the unsupplemented diets.	Quercetin	8-17	tumor necrosis factor	Mus musculus	50-59
18986596-10	2009	Current findings indicate that apoE3 mice are more responsive to the TNF-alpha lowering properties of dietary quercetin supplementation as compared to apoE4 animals.	Quercetin	110-119	tumor necrosis factor	Mus musculus	69-78
19208367-4	2009	METHODS: HSP70 expression was down-regulated in cultured pancreatic cancer cells by exposure to quercetin, triptolide, or short interfering RNAs.	Quercetin	96-105	heat shock protein family A (Hsp70) member 4	Homo sapiens	9-14
19519916-14	2009	CONCLUSION: This paper demonstrated that preventive effect of quercetin on hepatocarcinoma in rats by RAPD-PCR, tracing the effect on p53 gene and by histopathological evidence.	Quercetin	62-71	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	134-137
19221726-0	2009	Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers.	Quercetin	21-30	ATP binding cassette subfamily B member 1	Homo sapiens	87-101
19221726-1	2009	OBJECTIVE: The aim of the present study was to assess whether quercetin exhibited any inhibitory effect on P-glycoprotein (P-gp)-mediated drug disposition in humans using fexofenadine as a P-gp substrate.	Quercetin	62-71	ATP binding cassette subfamily B member 1	Homo sapiens	107-121
19221726-1	2009	OBJECTIVE: The aim of the present study was to assess whether quercetin exhibited any inhibitory effect on P-glycoprotein (P-gp)-mediated drug disposition in humans using fexofenadine as a P-gp substrate.	Quercetin	62-71	ATP binding cassette subfamily B member 1	Homo sapiens	123-127
19221726-8	2009	CONCLUSION: The results of the present study showed that short-term use of quercetin elevated the plasma concentrations of fexofenadine, probably by the inhibition of P-gp-mediated efflux in humans.	Quercetin	75-84	ATP binding cassette subfamily B member 1	Homo sapiens	167-171
19424582-5	2009	From 117 kinds of chemicals (34 kinds of natural compounds that are obtained from herbal plants, 53 kinds of flavonoid, and 31 kinds of phenolic compounds), we find that quercetin works as an activator of p53 in K-Ras mutated cells but not in wild-type cells.	Quercetin	170-179	tumor protein p53	Homo sapiens	205-208
19424582-5	2009	From 117 kinds of chemicals (34 kinds of natural compounds that are obtained from herbal plants, 53 kinds of flavonoid, and 31 kinds of phenolic compounds), we find that quercetin works as an activator of p53 in K-Ras mutated cells but not in wild-type cells.	Quercetin	170-179	KRAS proto-oncogene, GTPase	Homo sapiens	212-217
19424582-6	2009	Treatment with quercetin can induce p53 target genes such as PUMA and p21.	Quercetin	15-24	tumor protein p53	Homo sapiens	36-39
19424582-7	2009	These results suggest that although quercetin has limitations for use as a therapeutic drug due to its broad effects, specific function of it on K-Ras-p53 may be useful for K-Ras-induced cancer prevention and therapy through further development.	Quercetin	36-45	tumor protein p53	Homo sapiens	151-154
19424582-7	2009	These results suggest that although quercetin has limitations for use as a therapeutic drug due to its broad effects, specific function of it on K-Ras-p53 may be useful for K-Ras-induced cancer prevention and therapy through further development.	Quercetin	36-45	KRAS proto-oncogene, GTPase	Homo sapiens	173-178
19194971-0	2009	Quercetin-induced apoptotic cascade in cancer cells: antioxidant versus estrogen receptor alpha-dependent mechanisms.	Quercetin	0-9	estrogen receptor 1	Homo sapiens	72-95
19194971-8	2009	Taken together, these findings suggest that quercetin results in HeLa cell death through an ERalpha-dependent mechanism involving caspase- and p38 kinase activation.	Quercetin	44-53	estrogen receptor 1	Homo sapiens	92-99
19194971-8	2009	Taken together, these findings suggest that quercetin results in HeLa cell death through an ERalpha-dependent mechanism involving caspase- and p38 kinase activation.	Quercetin	44-53	mitogen-activated protein kinase 14	Homo sapiens	143-146
19297429-0	2009	Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells.	Quercetin	0-9	claudin 1	Homo sapiens	117-126
19297429-0	2009	Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells.	Quercetin	0-9	claudin 4	Homo sapiens	149-158
19297429-4	2009	Immunoblot analysis of tight junction (TJ) proteins revealed that zonula occludens (ZO)-2, occludin, and claudin-1 were distributed to the actin cytoskeleton fraction by quercetin without increasing their respective whole-cell levels and this distribution was correlated with the increases in TER.	Quercetin	170-179	tight junction protein 2	Homo sapiens	66-89
19297429-4	2009	Immunoblot analysis of tight junction (TJ) proteins revealed that zonula occludens (ZO)-2, occludin, and claudin-1 were distributed to the actin cytoskeleton fraction by quercetin without increasing their respective whole-cell levels and this distribution was correlated with the increases in TER.	Quercetin	170-179	occludin	Homo sapiens	91-99
19297429-4	2009	Immunoblot analysis of tight junction (TJ) proteins revealed that zonula occludens (ZO)-2, occludin, and claudin-1 were distributed to the actin cytoskeleton fraction by quercetin without increasing their respective whole-cell levels and this distribution was correlated with the increases in TER.	Quercetin	170-179	claudin 1	Homo sapiens	105-114
19297429-5	2009	The claudin-4 level was elevated by quercetin in both the cytoskeleton fraction and whole cells after 12 h. Confocal microscopy showed the assembly of claudin-1 and -4 at the TJ by quercetin.	Quercetin	36-45	claudin 4	Homo sapiens	4-13
19297429-5	2009	The claudin-4 level was elevated by quercetin in both the cytoskeleton fraction and whole cells after 12 h. Confocal microscopy showed the assembly of claudin-1 and -4 at the TJ by quercetin.	Quercetin	36-45	claudin 1	Homo sapiens	151-167
19297429-5	2009	The claudin-4 level was elevated by quercetin in both the cytoskeleton fraction and whole cells after 12 h. Confocal microscopy showed the assembly of claudin-1 and -4 at the TJ by quercetin.	Quercetin	181-190	claudin 4	Homo sapiens	4-13
19297429-5	2009	The claudin-4 level was elevated by quercetin in both the cytoskeleton fraction and whole cells after 12 h. Confocal microscopy showed the assembly of claudin-1 and -4 at the TJ by quercetin.	Quercetin	181-190	claudin 1	Homo sapiens	151-167
19297429-7	2009	Phosphorylation of PKCdelta indicating the enzymatic activity in the cells was decreased by quercetin after 1 h. In the kinase assay, quercetin exhibits direct inhibition of the PKCdelta isoform.	Quercetin	92-101	protein kinase C delta	Homo sapiens	19-27
19191009-4	2009	Real-time PCR conducted with RNA samples from individual rats fed varying amounts of quercetin together with the microarray analysis showed that quercetin caused marked dose-dependent increases in the mRNA expression of Gsta3, Gstp1, and Gstt3.	Quercetin	85-94	glutathione S-transferase alpha 3	Rattus norvegicus	220-225
19191009-4	2009	Real-time PCR conducted with RNA samples from individual rats fed varying amounts of quercetin together with the microarray analysis showed that quercetin caused marked dose-dependent increases in the mRNA expression of Gsta3, Gstp1, and Gstt3.	Quercetin	145-154	glutathione S-transferase alpha 3	Rattus norvegicus	220-225
19297429-7	2009	Phosphorylation of PKCdelta indicating the enzymatic activity in the cells was decreased by quercetin after 1 h. In the kinase assay, quercetin exhibits direct inhibition of the PKCdelta isoform.	Quercetin	92-101	protein kinase C delta	Homo sapiens	178-186
19191009-4	2009	Real-time PCR conducted with RNA samples from individual rats fed varying amounts of quercetin together with the microarray analysis showed that quercetin caused marked dose-dependent increases in the mRNA expression of Gsta3, Gstp1, and Gstt3.	Quercetin	145-154	glutathione S-transferase pi 1	Rattus norvegicus	227-232
19297429-7	2009	Phosphorylation of PKCdelta indicating the enzymatic activity in the cells was decreased by quercetin after 1 h. In the kinase assay, quercetin exhibits direct inhibition of the PKCdelta isoform.	Quercetin	134-143	protein kinase C delta	Homo sapiens	19-27
19297429-7	2009	Phosphorylation of PKCdelta indicating the enzymatic activity in the cells was decreased by quercetin after 1 h. In the kinase assay, quercetin exhibits direct inhibition of the PKCdelta isoform.	Quercetin	134-143	protein kinase C delta	Homo sapiens	178-186
19191009-4	2009	Real-time PCR conducted with RNA samples from individual rats fed varying amounts of quercetin together with the microarray analysis showed that quercetin caused marked dose-dependent increases in the mRNA expression of Gsta3, Gstp1, and Gstt3.	Quercetin	145-154	glutathione S-transferase, theta 3	Rattus norvegicus	238-243
19297429-8	2009	This study demonstrates that quercetin enhances the intestinal barrier function through the assembly of ZO-2, occludin, and claudin-1 by inhibiting PKCdelta and the increase in claudin-4 expression has an additional role after 12 h.	Quercetin	29-38	tight junction protein 2	Homo sapiens	104-108
19191009-6	2009	Quercetin also dose-dependently increased the mRNA expression of Akr1b8 and Akr7a3.	Quercetin	0-9	aldo-keto reductase family 1, member B8	Rattus norvegicus	65-71
19297429-8	2009	This study demonstrates that quercetin enhances the intestinal barrier function through the assembly of ZO-2, occludin, and claudin-1 by inhibiting PKCdelta and the increase in claudin-4 expression has an additional role after 12 h.	Quercetin	29-38	occludin	Homo sapiens	110-118
19191009-6	2009	Quercetin also dose-dependently increased the mRNA expression of Akr1b8 and Akr7a3.	Quercetin	0-9	aldo-keto reductase family 7 member A3	Rattus norvegicus	76-82
19297429-8	2009	This study demonstrates that quercetin enhances the intestinal barrier function through the assembly of ZO-2, occludin, and claudin-1 by inhibiting PKCdelta and the increase in claudin-4 expression has an additional role after 12 h.	Quercetin	29-38	claudin 1	Homo sapiens	124-133
19297429-8	2009	This study demonstrates that quercetin enhances the intestinal barrier function through the assembly of ZO-2, occludin, and claudin-1 by inhibiting PKCdelta and the increase in claudin-4 expression has an additional role after 12 h.	Quercetin	29-38	protein kinase C delta	Homo sapiens	148-156
19297429-8	2009	This study demonstrates that quercetin enhances the intestinal barrier function through the assembly of ZO-2, occludin, and claudin-1 by inhibiting PKCdelta and the increase in claudin-4 expression has an additional role after 12 h.	Quercetin	29-38	claudin 4	Homo sapiens	177-186
19548565-2	2009	METHODS: The combined application of ABTS and FRAP methods in the assessments, using the UV-VIS spectrophotometer and the autoanalyzer respectively test the antioxidant capacity of quercetin, curcumin, DL-alpha-tocopherol and procyanidine at 734 nm in ABTS and at 595 nm in FRAP.	Quercetin	181-190	mechanistic target of rapamycin kinase	Homo sapiens	46-50
19548565-5	2009	FRAP: Used 1.0 mmol/L FeSO4 as the reference standard, quercetin, curcumin and Trolox equivalent molar about 5.73, 1.18 and 2.09.	Quercetin	55-64	mechanistic target of rapamycin kinase	Homo sapiens	0-4
19428936-6	2009	The results showed that quercetin suppressed the induction of GRP78 expression by these ER stressors, excepting brefeldin A, at both the mRNA and protein levels.	Quercetin	24-33	heat shock protein family A (Hsp70) member 5	Homo sapiens	62-67
19428936-9	2009	Although quercetin activated IRE1 and PERK when added to LS180 cells alone, it suppressed the activation of IRE1 and PERK induced by A23187 or thapsigargin.	Quercetin	9-18	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	29-33
19428936-9	2009	Although quercetin activated IRE1 and PERK when added to LS180 cells alone, it suppressed the activation of IRE1 and PERK induced by A23187 or thapsigargin.	Quercetin	9-18	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	38-42
19428936-9	2009	Although quercetin activated IRE1 and PERK when added to LS180 cells alone, it suppressed the activation of IRE1 and PERK induced by A23187 or thapsigargin.	Quercetin	9-18	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	108-112
19428936-9	2009	Although quercetin activated IRE1 and PERK when added to LS180 cells alone, it suppressed the activation of IRE1 and PERK induced by A23187 or thapsigargin.	Quercetin	9-18	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	117-121
19428936-10	2009	The suppressive effect of quercetin on GRP78 mRNA induction was reproduced by PI3K inhibitors (LY294002 and wortmannin), but not by vitamin C and E. LY294002 failed to suppress the GRP78 mRNA induction in combination with quercetin.	Quercetin	26-35	heat shock protein family A (Hsp70) member 5	Homo sapiens	39-44
19426678-8	2009	Structural analogs of luteolin such as quercetin, chrysin, and eriodictyol also inhibited TBK1-kinase activity and TBK1-target gene expression.	Quercetin	39-48	TANK binding kinase 1	Homo sapiens	115-119
19426678-8	2009	Structural analogs of luteolin such as quercetin, chrysin, and eriodictyol also inhibited TBK1-kinase activity and TBK1-target gene expression.	Quercetin	39-48	TANK binding kinase 1	Homo sapiens	90-94
19286049-2	2009	In this study, we investigated the genetic-, time-, dose-, species- and tissue-dependent AhR-mediated agonistic/antagonistic activities of three food flavonoids: quercetin, chrysin and genistein.	Quercetin	162-171	aryl hydrocarbon receptor	Homo sapiens	89-92
19211721-7	2009	Quercetin increased mRNA expression of PGC-1alpha and SIRT1 (P &lt; 0.05), mtDNA (P &lt; 0.05) and cytochrome c concentration (P &lt; 0.05).	Quercetin	0-9	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	39-49
19211721-7	2009	Quercetin increased mRNA expression of PGC-1alpha and SIRT1 (P &lt; 0.05), mtDNA (P &lt; 0.05) and cytochrome c concentration (P &lt; 0.05).	Quercetin	0-9	sirtuin 1	Mus musculus	54-59
19296652-3	2009	Herein, we report the ability of five monomethyl and five carbomethoxymethyl derivatives of quercetin to inhibit heat-induced HSP70 expression and enhance HSP27 phosphorylation in human cells.	Quercetin	92-101	heat shock protein family A (Hsp70) member 4	Homo sapiens	126-131
19296652-3	2009	Herein, we report the ability of five monomethyl and five carbomethoxymethyl derivatives of quercetin to inhibit heat-induced HSP70 expression and enhance HSP27 phosphorylation in human cells.	Quercetin	92-101	heat shock protein family B (small) member 1	Homo sapiens	155-160
19296652-4	2009	While quercetin and several derivatives inhibit HSP70 induction and enhance HSP27 phosphorylation at Ser78, other analogues selectively inhibit HSP70 induction without enhancing HSP27 phosphorylation that would otherwise aid in cell survival.	Quercetin	6-15	heat shock protein family A (Hsp70) member 4	Homo sapiens	48-53
19296652-4	2009	While quercetin and several derivatives inhibit HSP70 induction and enhance HSP27 phosphorylation at Ser78, other analogues selectively inhibit HSP70 induction without enhancing HSP27 phosphorylation that would otherwise aid in cell survival.	Quercetin	6-15	heat shock protein family B (small) member 1	Homo sapiens	76-81
18688565-0	2009	Role of transglutaminase 2 in quercetin-induced differentiation of B16-F10 murine melanoma cells.	Quercetin	30-39	transglutaminase 2, C polypeptide	Mus musculus	8-26
19207477-9	2009	Administration of quercetin reduced NOX2, eNOS, and iNOS mRNA and protein expression both in control and in I/R heart (P &lt; 0.01).	Quercetin	18-27	nitric oxide synthase, endothelial	Oryctolagus cuniculus	42-46
19414395-2	2009	This study was designed to investigate the effects of quercetin (3,5,7,3",4"-pentahydroxyflavanone), a P-gp and CYP3A inhibitor, on the pharmacokinetics of etoposide in rats.	Quercetin	54-63	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	103-107
19414395-2	2009	This study was designed to investigate the effects of quercetin (3,5,7,3",4"-pentahydroxyflavanone), a P-gp and CYP3A inhibitor, on the pharmacokinetics of etoposide in rats.	Quercetin	54-63	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	112-117
19414395-11	2009	The enhanced oral bioavailability of etoposide by quercetin could mainly be due to inhibition of P-gp-mediated efflux and CYP3A-catalyzed metabolism in the intestine by quercetin.	Quercetin	50-59	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	97-101
19414395-11	2009	The enhanced oral bioavailability of etoposide by quercetin could mainly be due to inhibition of P-gp-mediated efflux and CYP3A-catalyzed metabolism in the intestine by quercetin.	Quercetin	50-59	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	122-127
19414395-11	2009	The enhanced oral bioavailability of etoposide by quercetin could mainly be due to inhibition of P-gp-mediated efflux and CYP3A-catalyzed metabolism in the intestine by quercetin.	Quercetin	169-178	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	122-127
19207477-9	2009	Administration of quercetin reduced NOX2, eNOS, and iNOS mRNA and protein expression both in control and in I/R heart (P &lt; 0.01).	Quercetin	18-27	cytochrome b-245 heavy chain	Oryctolagus cuniculus	36-40
19207477-9	2009	Administration of quercetin reduced NOX2, eNOS, and iNOS mRNA and protein expression both in control and in I/R heart (P &lt; 0.01).	Quercetin	18-27	nitric oxide synthase, inducible	Oryctolagus cuniculus	52-56
19207477-11	2009	Quercetin not only inhibited myocardial ischemia-reperfusion-induced NOX2 and iNOS mRNA and protein expression but also inhibited eNOS mRNA and protein expression.	Quercetin	0-9	cytochrome b-245 heavy chain	Oryctolagus cuniculus	69-73
19207477-11	2009	Quercetin not only inhibited myocardial ischemia-reperfusion-induced NOX2 and iNOS mRNA and protein expression but also inhibited eNOS mRNA and protein expression.	Quercetin	0-9	nitric oxide synthase, inducible	Oryctolagus cuniculus	78-82
19207477-11	2009	Quercetin not only inhibited myocardial ischemia-reperfusion-induced NOX2 and iNOS mRNA and protein expression but also inhibited eNOS mRNA and protein expression.	Quercetin	0-9	nitric oxide synthase, endothelial	Oryctolagus cuniculus	130-134
19244381-0	2009	The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration.	Quercetin	14-23	hepatocyte growth factor	Homo sapiens	59-83
19131519-6	2009	In human liver S9, quercetin, a highly selective inhibitor of SULT1A1 and SULT1E1, inhibited O-demethyl apixaban sulfate formation by 99%; 2,6-dichloro-4-nitrophenol, another inhibitor of SULT1A1, also inhibited this reaction by &gt;90%; estrone, a competitive inhibitor for SULT1E1, had no effect on this reaction.	Quercetin	19-28	sulfotransferase family 1A member 1	Homo sapiens	62-69
19131519-6	2009	In human liver S9, quercetin, a highly selective inhibitor of SULT1A1 and SULT1E1, inhibited O-demethyl apixaban sulfate formation by 99%; 2,6-dichloro-4-nitrophenol, another inhibitor of SULT1A1, also inhibited this reaction by &gt;90%; estrone, a competitive inhibitor for SULT1E1, had no effect on this reaction.	Quercetin	19-28	sulfotransferase family 1E member 1	Homo sapiens	74-81
19131519-6	2009	In human liver S9, quercetin, a highly selective inhibitor of SULT1A1 and SULT1E1, inhibited O-demethyl apixaban sulfate formation by 99%; 2,6-dichloro-4-nitrophenol, another inhibitor of SULT1A1, also inhibited this reaction by &gt;90%; estrone, a competitive inhibitor for SULT1E1, had no effect on this reaction.	Quercetin	19-28	sulfotransferase family 1A member 1	Homo sapiens	188-195
19131519-6	2009	In human liver S9, quercetin, a highly selective inhibitor of SULT1A1 and SULT1E1, inhibited O-demethyl apixaban sulfate formation by 99%; 2,6-dichloro-4-nitrophenol, another inhibitor of SULT1A1, also inhibited this reaction by &gt;90%; estrone, a competitive inhibitor for SULT1E1, had no effect on this reaction.	Quercetin	19-28	sulfotransferase family 1E member 1	Homo sapiens	275-282
19244381-3	2009	Using immunoblotting procedures, we observed that the dietary-derived flavonols quercetin, kaempferol, and myricetin inhibited HGF/Met signaling in a medulloblastoma cell line (DAOY), preventing the formation of actin-rich membrane ruffles and resulting in the inhibition of Met-induced cell migration in Boyden chambers.	Quercetin	80-89	hepatocyte growth factor	Homo sapiens	127-130
19244381-4	2009	Furthermore, quercetin and kaempferol also strongly diminished HGF-mediated Akt activation.	Quercetin	13-22	hepatocyte growth factor	Homo sapiens	63-66
18971417-4	2009	Combining quercetin with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) strongly augmented TRAIL-mediated apoptosis in U87-MG, U251, A172, and LN229 glioma cells; U373 cells could not be sensitized by quercetin to TRAIL-mediated apoptosis.	Quercetin	10-19	TNF superfamily member 10	Homo sapiens	82-87
19153242-8	2009	Using a gene-silencing approach and quercetin as a chemical inhibitor to downregulate Hsp70 levels, we also confirm the significance of cytosolic Hsp70 in the replication of TBSV and other plant viruses in a plant host.	Quercetin	36-45	heat shock protein family A (Hsp70) member 4	Homo sapiens	86-91
18971417-5	2009	TRAIL-induced apoptosis was enhanced by quercetin-induced reduction of survivin protein levels.	Quercetin	40-49	TNF superfamily member 10	Homo sapiens	0-5
18971417-4	2009	Combining quercetin with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) strongly augmented TRAIL-mediated apoptosis in U87-MG, U251, A172, and LN229 glioma cells; U373 cells could not be sensitized by quercetin to TRAIL-mediated apoptosis.	Quercetin	10-19	TNF superfamily member 10	Homo sapiens	108-113
18971417-8	2009	TRAIL-quercetin-induced apoptosis was markedly reduced by overexpression of survivin.	Quercetin	6-15	TNF superfamily member 10	Homo sapiens	0-5
18971417-4	2009	Combining quercetin with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) strongly augmented TRAIL-mediated apoptosis in U87-MG, U251, A172, and LN229 glioma cells; U373 cells could not be sensitized by quercetin to TRAIL-mediated apoptosis.	Quercetin	10-19	TNF superfamily member 10	Homo sapiens	108-113
18971417-4	2009	Combining quercetin with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) strongly augmented TRAIL-mediated apoptosis in U87-MG, U251, A172, and LN229 glioma cells; U373 cells could not be sensitized by quercetin to TRAIL-mediated apoptosis.	Quercetin	218-227	TNF superfamily member 10	Homo sapiens	25-80
18971417-4	2009	Combining quercetin with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) strongly augmented TRAIL-mediated apoptosis in U87-MG, U251, A172, and LN229 glioma cells; U373 cells could not be sensitized by quercetin to TRAIL-mediated apoptosis.	Quercetin	218-227	TNF superfamily member 10	Homo sapiens	82-87
19034627-5	2009	Cell-based reporter assays in HepG2 revealed that GA and GB are potent activators of PXR; quercetin and kaempferol activate PXR, CAR, and AhR, whereas BB exerts no effects on these xenobiotic receptors.	Quercetin	90-99	nuclear receptor subfamily 1 group I member 3	Homo sapiens	129-132
19207037-0	2009	Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration.	Quercetin	60-69	IQ motif containing GTPase activating protein 1	Homo sapiens	79-85
19207037-0	2009	Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration.	Quercetin	98-107	IQ motif containing GTPase activating protein 1	Homo sapiens	79-85
19207037-6	2009	The migration inhibition of HepG2 cells can be induced by quercetin, and the RNA and protein expression level of IQGAP1 and beta-tubulin were respectively decreased obviously in HepG2 cells exposed to quercetin for 48 h in the scratch migration assay.	Quercetin	201-210	IQ motif containing GTPase activating protein 1	Homo sapiens	113-119
19207037-7	2009	The downregulated expression of IQGAP1 and beta-tubulin by quercetin treatment correlated with cell migration ability, and quercetin probably inhibits HepG2 proliferation and migration through IQGAP1 and beta-tubulin expression changes and their interactions with other proteins.	Quercetin	59-68	IQ motif containing GTPase activating protein 1	Homo sapiens	32-38
19207037-7	2009	The downregulated expression of IQGAP1 and beta-tubulin by quercetin treatment correlated with cell migration ability, and quercetin probably inhibits HepG2 proliferation and migration through IQGAP1 and beta-tubulin expression changes and their interactions with other proteins.	Quercetin	123-132	IQ motif containing GTPase activating protein 1	Homo sapiens	193-199
19034627-4	2009	RESULTS: In human primary hepatocytes, real-time PCR analysis showed induction of CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2 by EGb 761, ginkgolide A (GA) and ginkgolide B (GB), but not by bilobalide (BB) or the flavonoids (quercetin, kaempferol and tamarixetin) of GBE.	Quercetin	220-229	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	82-88
19034627-4	2009	RESULTS: In human primary hepatocytes, real-time PCR analysis showed induction of CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2 by EGb 761, ginkgolide A (GA) and ginkgolide B (GB), but not by bilobalide (BB) or the flavonoids (quercetin, kaempferol and tamarixetin) of GBE.	Quercetin	220-229	ATP binding cassette subfamily B member 1	Homo sapiens	106-110
19034627-5	2009	Cell-based reporter assays in HepG2 revealed that GA and GB are potent activators of PXR; quercetin and kaempferol activate PXR, CAR, and AhR, whereas BB exerts no effects on these xenobiotic receptors.	Quercetin	90-99	nuclear receptor subfamily 1 group I member 2	Homo sapiens	85-88
19034627-5	2009	Cell-based reporter assays in HepG2 revealed that GA and GB are potent activators of PXR; quercetin and kaempferol activate PXR, CAR, and AhR, whereas BB exerts no effects on these xenobiotic receptors.	Quercetin	90-99	nuclear receptor subfamily 1 group I member 2	Homo sapiens	124-127
19034627-5	2009	Cell-based reporter assays in HepG2 revealed that GA and GB are potent activators of PXR; quercetin and kaempferol activate PXR, CAR, and AhR, whereas BB exerts no effects on these xenobiotic receptors.	Quercetin	90-99	aryl hydrocarbon receptor	Homo sapiens	138-141
19364325-3	2009	Peroxidase activity of the complex of cytochrome c with dioleyl cardiolipin estimated by chemiluminescence with luminol decreased by 50% with quercetin, taxifolin, rutin, Trolox, and ionol at concentrations 0.7, 0.7, 0.8, 3, and 10 microM, respectively.	Quercetin	142-151	cytochrome c, somatic	Homo sapiens	38-50
19293639-0	2009	AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin.	Quercetin	103-112	prostaglandin-endoperoxide synthase 2	Homo sapiens	11-27
19293639-3	2009	In this study, quercetin activated AMPK in MCF breast cancer cell lines and HT-29 colon cancer cells, and this activation of AMPK seemed to be closely related to a decrease in COX-2 expression.	Quercetin	15-24	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	35-39
19293639-3	2009	In this study, quercetin activated AMPK in MCF breast cancer cell lines and HT-29 colon cancer cells, and this activation of AMPK seemed to be closely related to a decrease in COX-2 expression.	Quercetin	15-24	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	125-129
19293639-3	2009	In this study, quercetin activated AMPK in MCF breast cancer cell lines and HT-29 colon cancer cells, and this activation of AMPK seemed to be closely related to a decrease in COX-2 expression.	Quercetin	15-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-181
19293639-4	2009	The application of a COX-2 inhibitor or cox-2-/- cells supported the idea that AMPK is an upstream signal of COX-2, and is required for the anti-proliferatory and pro-apoptotic effects of quercetin.	Quercetin	188-197	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
19293639-4	2009	The application of a COX-2 inhibitor or cox-2-/- cells supported the idea that AMPK is an upstream signal of COX-2, and is required for the anti-proliferatory and pro-apoptotic effects of quercetin.	Quercetin	188-197	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	79-83
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	48-57	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	115-119
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	48-57	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	169-173
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	48-57	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	169-173
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	242-247
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	214-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	214-223	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	115-119
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	214-223	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	169-173
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	214-223	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	169-173
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	214-223	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	214-223	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	115-119
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	214-223	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	169-173
19293639-5	2009	The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.	Quercetin	214-223	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	169-173
19196000-0	2009	Blockade of oxidized LDL-triggered endothelial apoptosis by quercetin and rutin through differential signaling pathways involving JAK2.	Quercetin	60-69	Janus kinase 2	Homo sapiens	130-134
19196000-8	2009	Quercetin dose-dependently attenuated the JAK2 phosphorylation evoked by oxidized LDL, whereas rutin abolished the JAK signaling accompanying nuclear transactivation of STAT3 and enhanced the JAK activity-inhibiting SOCS3 expression.	Quercetin	0-9	Janus kinase 2	Homo sapiens	42-46
19196000-10	2009	These results suggest that quercetin and rutin inhibit Cu(2+)-oxidized LDL-induced endothelial apoptosis through modulating JAK2-STAT3 pathways and that rutin may modulate a signaling crosstalk between JAK2 and MAPK.	Quercetin	27-36	Janus kinase 2	Homo sapiens	124-128
19196000-10	2009	These results suggest that quercetin and rutin inhibit Cu(2+)-oxidized LDL-induced endothelial apoptosis through modulating JAK2-STAT3 pathways and that rutin may modulate a signaling crosstalk between JAK2 and MAPK.	Quercetin	27-36	signal transducer and activator of transcription 3	Homo sapiens	129-134
19196000-10	2009	These results suggest that quercetin and rutin inhibit Cu(2+)-oxidized LDL-induced endothelial apoptosis through modulating JAK2-STAT3 pathways and that rutin may modulate a signaling crosstalk between JAK2 and MAPK.	Quercetin	27-36	Janus kinase 2	Homo sapiens	202-206
19061976-0	2009	Quercetin regulates Th1/Th2 balance in a murine model of asthma.	Quercetin	0-9	negative elongation factor complex member C/D, Th1l	Mus musculus	20-23
19074529-1	2009	This article describes an in vitro investigation of the inhibition of cytochrome P450 (P450) 2C9 by a series of flavonoids made up of flavones (flavone, 6-hydroxyflavone, 7-hydroxyflavone, chrysin, baicalein, apigenin, luteolin, scutellarein, and wogonin) and flavonols (galangin, fisetin, kaempferol, morin, and quercetin).	Quercetin	313-322	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-96
19061976-0	2009	Quercetin regulates Th1/Th2 balance in a murine model of asthma.	Quercetin	0-9	heart and neural crest derivatives expressed 2	Mus musculus	24-27
19061976-5	2009	In this study, we have attempted to determine whether Quercetin regulates Th1/Th2 cytokine production, T-bet and GATA-3 gene expression in OVA-induced asthma model mice.	Quercetin	54-63	negative elongation factor complex member C/D, Th1l	Mus musculus	74-77
19061976-5	2009	In this study, we have attempted to determine whether Quercetin regulates Th1/Th2 cytokine production, T-bet and GATA-3 gene expression in OVA-induced asthma model mice.	Quercetin	54-63	heart and neural crest derivatives expressed 2	Mus musculus	78-81
19061976-5	2009	In this study, we have attempted to determine whether Quercetin regulates Th1/Th2 cytokine production, T-bet and GATA-3 gene expression in OVA-induced asthma model mice.	Quercetin	54-63	T-box 21	Mus musculus	103-108
19061976-5	2009	In this study, we have attempted to determine whether Quercetin regulates Th1/Th2 cytokine production, T-bet and GATA-3 gene expression in OVA-induced asthma model mice.	Quercetin	54-63	GATA binding protein 3	Mus musculus	113-119
19061976-6	2009	Quercetin reduced the increased levels of IL-4, Th2 cytokine production in OVA-sensitized and -challenged mice.	Quercetin	0-9	interleukin 4	Mus musculus	42-46
19061976-6	2009	Quercetin reduced the increased levels of IL-4, Th2 cytokine production in OVA-sensitized and -challenged mice.	Quercetin	0-9	heart and neural crest derivatives expressed 2	Mus musculus	48-51
19061976-7	2009	The other side, it increased IFN-gamma, Th1 cytokine production in Quercetin administrated mice.	Quercetin	67-76	interferon gamma	Mus musculus	29-38
19061976-7	2009	The other side, it increased IFN-gamma, Th1 cytokine production in Quercetin administrated mice.	Quercetin	67-76	negative elongation factor complex member C/D, Th1l	Mus musculus	40-43
19061976-8	2009	We also examined to ascertain whether Quercetin could influence Eosinophil peroxidase (EPO) activity.	Quercetin	38-47	eosinophil peroxidase	Mus musculus	64-85
19061976-8	2009	We also examined to ascertain whether Quercetin could influence Eosinophil peroxidase (EPO) activity.	Quercetin	38-47	eosinophil peroxidase	Mus musculus	87-90
19462895-5	2009	HSP70 and VEGF were both significantly reduced by quercetin or combination treatment, but no significant difference was seen between quercetin and combination treatment groups.	Quercetin	50-59	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	0-5
19183254-9	2009	Our results indicate that GCLM is essential for the up-regulation of GCL activity induced by curcumin, quercetin and tBHQ.	Quercetin	103-112	glutamate-cysteine ligase, modifier subunit	Mus musculus	26-30
19183254-9	2009	Our results indicate that GCLM is essential for the up-regulation of GCL activity induced by curcumin, quercetin and tBHQ.	Quercetin	103-112	glutamate-cysteine ligase, modifier subunit	Mus musculus	26-29
19141295-0	2009	Quercetin up-regulates paraoxonase 1 gene expression with concomitant protection against LDL oxidation.	Quercetin	0-9	paraoxonase 1	Rattus norvegicus	23-36
19141295-3	2009	We explored the roles of quercetin in the regulation of PON1 expression, serum and liver activity and protective capacity of HDL against LDL oxidation in rats.	Quercetin	25-34	paraoxonase 1	Rattus norvegicus	56-60
19141295-4	2009	Compared to the pair-fed control group, feeding quercetin (10 mg/L) in the liquid diet for 4 weeks increased (a) hepatic expression of PON1 by 35% (p&lt;0.01), (b) serum and liver PON1 activities by 29% (p&lt;0.05) and 57% (p&lt;0.01), respectively, and (c) serum homocysteine thiolactonase (HCTL) activity by 23% (p&lt;0.05).	Quercetin	48-57	paraoxonase 1	Rattus norvegicus	135-139
19141295-4	2009	Compared to the pair-fed control group, feeding quercetin (10 mg/L) in the liquid diet for 4 weeks increased (a) hepatic expression of PON1 by 35% (p&lt;0.01), (b) serum and liver PON1 activities by 29% (p&lt;0.05) and 57% (p&lt;0.01), respectively, and (c) serum homocysteine thiolactonase (HCTL) activity by 23% (p&lt;0.05).	Quercetin	48-57	paraoxonase 1	Rattus norvegicus	180-184
19141295-6	2009	Our data suggest that quercetin has antiatherogenic effect by up regulating PON1 gene expression and its protective capacity against LDL oxidation.	Quercetin	22-31	paraoxonase 1	Rattus norvegicus	76-80
19010653-9	2009	Quercetin significantly decreased ex vivo LPS-induced TNFalpha- and IL-8 production in a concentration-dependent manner in both groups.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	54-62
19010653-9	2009	Quercetin significantly decreased ex vivo LPS-induced TNFalpha- and IL-8 production in a concentration-dependent manner in both groups.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
19462895-5	2009	HSP70 and VEGF were both significantly reduced by quercetin or combination treatment, but no significant difference was seen between quercetin and combination treatment groups.	Quercetin	50-59	vascular endothelial growth factor A	Rattus norvegicus	10-14
19462895-6	2009	CONCLUSION: Quercetin inhibits surgically induced endometriosis in rats, and the possible mechanism is to inhibit the expression of HSP70 and VEGF.	Quercetin	12-21	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	132-137
19462895-6	2009	CONCLUSION: Quercetin inhibits surgically induced endometriosis in rats, and the possible mechanism is to inhibit the expression of HSP70 and VEGF.	Quercetin	12-21	vascular endothelial growth factor A	Rattus norvegicus	142-146
18986330-0	2009	Quercetin activates human Kv1.5 channels by a residue I502 in the S6 segment.	Quercetin	0-9	potassium voltage-gated channel subfamily A member 5	Homo sapiens	26-31
19121944-7	2009	In ALR2, Thr113 (Tyr116 in ALR1) forms electrostatic interactions with the fluorobenzyl moiety of Minalrestat and the 3- and 4-hydroxy groups on the phenyl ring of quercetin.	Quercetin	164-173	aldo-keto reductase family 1 member B	Homo sapiens	3-7
19116149-4	2009	Although all of them protect the heart from ischemia/reperfusion-injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation.	Quercetin	146-155	signal transducer and activator of transcription 1	Homo sapiens	185-190
18489909-5	2009	Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	29-37
18489909-5	2009	Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC.	Quercetin	0-9	vascular cell adhesion molecule 1	Homo sapiens	62-68
18489909-5	2009	Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC.	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	70-76
18489909-5	2009	Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC.	Quercetin	0-9	C-C motif chemokine ligand 2	Homo sapiens	81-86
18986330-6	2009	Quercetin increased WT hKv1.5 channel current in a concentration-, voltage- and time-dependent manner, with an EC(50) of 37.8 micromol/L and a negative shift in the steady state activation and inactivation curves.	Quercetin	0-9	potassium voltage-gated channel subfamily A member 5	Homo sapiens	23-29
18986330-13	2009	We conclude that: (i) quercetin preferentially binds to and increases the current amplitude of WT hKv1.5 channels; (ii) Ile502, an aliphatic and neutral amino acid residue residing in the S6 segment, is important in quercetin binding; and (iii) quercetin-induced changes in the properties of WT hKv1.5 channels may be foreign to its own anti-oxidant action.	Quercetin	22-31	potassium voltage-gated channel subfamily A member 5	Homo sapiens	98-104
18986330-13	2009	We conclude that: (i) quercetin preferentially binds to and increases the current amplitude of WT hKv1.5 channels; (ii) Ile502, an aliphatic and neutral amino acid residue residing in the S6 segment, is important in quercetin binding; and (iii) quercetin-induced changes in the properties of WT hKv1.5 channels may be foreign to its own anti-oxidant action.	Quercetin	22-31	potassium voltage-gated channel subfamily A member 5	Homo sapiens	295-301
19296209-4	2009	In addition 50 microM quercetin inhibited the adenine nucleotide translocase (ANT) by 46%.	Quercetin	22-31	solute carrier family 25 member 6	Homo sapiens	78-81
19115120-6	2009	Quercetin increased the levels of both GSH and of total glutathione, it increased the GSH/GSSG index and it caused a rapid and simultaneous elevation in the activities of superoxide dismutase, glutathione peroxidase and catalase.	Quercetin	0-9	catalase	Homo sapiens	220-228
19296209-6	2009	Quercetin-induced permeability transition pore opening was inhibited by 0.5 microM cyclosporin A, but, interestingly, the release of cytochrome c was not inhibited by the immunosuppressor, as quercetin was found to disrupt the outer membrane.	Quercetin	0-9	cytochrome c, somatic	Homo sapiens	133-145
19071085-4	2009	The putative SIRT1 activators resveratrol and quercetin also increased AMPK phosphorylation.	Quercetin	46-55	sirtuin 1	Homo sapiens	13-18
19262011-5	2009	Interestingly, EC, ECg, EGCg and quercetin significantly decreased the expression of atrogin-1 and MuRF-1 up-regulated by 3D-clinorotation, whereas they hardly affected atrogene expression induced by dexamethasone.	Quercetin	33-42	F-box protein 32	Mus musculus	85-94
19262011-5	2009	Interestingly, EC, ECg, EGCg and quercetin significantly decreased the expression of atrogin-1 and MuRF-1 up-regulated by 3D-clinorotation, whereas they hardly affected atrogene expression induced by dexamethasone.	Quercetin	33-42	tripartite motif-containing 63	Mus musculus	99-105
19262011-8	2009	As expected, EC, ECg, EGCg, and quercetin significantly suppressed phosphorylation of ERK, corresponding to the up-regulation of atrogenes induced by 3D-clinorotation.	Quercetin	32-41	mitogen-activated protein kinase 1	Mus musculus	86-89
19262011-9	2009	These results suggest that antioxidative nutrients, such as catechins and quercetin, suppress atrogene expression in skeletal muscle cells, possibly through the inhibition of ERK signaling.	Quercetin	74-83	mitogen-activated protein kinase 1	Mus musculus	175-178
19005466-8	2009	The recovery effect of Li was abolished by quercetin, an inhibitor of beta-catenin/TCF pathway.	Quercetin	43-52	catenin beta 1	Rattus norvegicus	70-82
19071085-4	2009	The putative SIRT1 activators resveratrol and quercetin also increased AMPK phosphorylation.	Quercetin	46-55	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	71-75
19946423-8	2009	Quercetin, a kinase inhibitor known to inhibit mouse and human HRI, inhibits canine HRI in a concentration-dependent manner.	Quercetin	0-9	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	63-66
20396589-9	2009	COX-1 expression was 20.2% lower (P &lt; 0.06) in rats consuming diets containing quercetin.	Quercetin	82-91	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	0-5
20396589-10	2009	COX-2 expression was 24.3% higher (P &lt; 0.058) in rats consuming diets without quercetin.	Quercetin	81-90	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5
20396589-11	2009	These data suggest inflammatory processes are elevated in this early stage of colon carcinogenesis, yet quercetin may protect against colon carcinogenesis by down-regulating the expressions of COX-1 and COX-2.	Quercetin	104-113	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	193-198
20396589-11	2009	These data suggest inflammatory processes are elevated in this early stage of colon carcinogenesis, yet quercetin may protect against colon carcinogenesis by down-regulating the expressions of COX-1 and COX-2.	Quercetin	104-113	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	203-208
19946423-8	2009	Quercetin, a kinase inhibitor known to inhibit mouse and human HRI, inhibits canine HRI in a concentration-dependent manner.	Quercetin	0-9	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	84-87
18436224-8	2009	Moreover, quercetin but not isorhamnetin, inhibited the increased PKC activity induced by ET-1.	Quercetin	10-19	endothelin 1	Homo sapiens	90-94
18436224-0	2009	Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC.	Quercetin	0-9	endothelin 1	Homo sapiens	61-73
18436224-9	2009	Taken together these results indicate that ET-1-induced NADPH oxidase up-regulation and eNOS uncoupling via PKC leading to endothelial dysfunction and these effects were prevented by quercetin and isorhamnetin.	Quercetin	183-192	endothelin 1	Homo sapiens	43-47
18436224-2	2009	We have investigated the effects of quercetin and its methylated metabolite isorhamnetin (1-10microM) on endothelial dysfunction and superoxide (O(2*)(-)) production induced by endothelin-1 (ET-1, 10nM).	Quercetin	36-45	endothelin 1	Homo sapiens	177-189
18436224-3	2009	ET-1 increased the contractile response induced by phenylephrine and reduced the relaxant responses to acetylcholine in phenylephrine contracted intact aorta, and these effects were prevented by co-incubation with quercetin, isorhamnetin or chelerythrine (protein kinase C (PKC) inhibitor).	Quercetin	214-223	endothelin 1	Homo sapiens	0-4
19009557-7	2009	In addition, quercetin down-regulated the cyclin B1 and CDK1, essential components of G(2)/M cell cycle progression.	Quercetin	13-22	cyclin dependent kinase 1	Homo sapiens	56-60
19661619-6	2009	Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain.	Quercetin	15-24	cAMP responsive element binding protein 1	Mus musculus	58-101
19661619-6	2009	Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain.	Quercetin	15-24	cAMP responsive element binding protein 1	Mus musculus	103-107
19661619-6	2009	Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain.	Quercetin	15-24	brain derived neurotrophic factor	Mus musculus	163-196
19661619-9	2009	The present findings suggest that enhanced neurogenesis and synaptogenesis by bilobalide and quercetin may share a common final signaling pathway mediated by phosphorylation of CREB.	Quercetin	93-102	cAMP responsive element binding protein 1	Mus musculus	177-181
18974642-0	2009	Quercetin is able to demethylate the p16INK4a gene promoter.	Quercetin	0-9	cyclin dependent kinase inhibitor 2A	Homo sapiens	37-45
18974642-7	2009	Hypermethylation of the p16INK4a gene was successfully reversed after 120 h of treatment with quercetin.	Quercetin	94-103	cyclin dependent kinase inhibitor 2A	Homo sapiens	24-32
18974642-9	2009	CONCLUSION: All these data suggest that quercetin has antitumor properties, probably via demethylation of the p16INK4a gene promoter.	Quercetin	40-49	cyclin dependent kinase inhibitor 2A	Homo sapiens	110-118
19897959-16	2009	Finally, food components can strengthen the epithelial barrier as for example the flavonoid quercetin which has been shown to upregulate claudin-4 within the epithelial TJ.	Quercetin	92-101	claudin 4	Homo sapiens	137-146
19317259-2	2009	METHODS: Proliferation and apoptosis of quercetin treated HeLa cells were measured by MTT and Annexin V-FITC/PI; adhesion and migration and invasion of quercetin treated HeLa cells were measured by adhesion assay and wound healing assay and the Transwell chamber method, respectively.	Quercetin	40-49	annexin A5	Homo sapiens	94-103
19009557-5	2009	Quercetin induced p21 CDK inhibitor with a concomitant decrease of phosphorylation of pRb, which inhibits the G(1)/S cell cycle progression by trapping E2F1.	Quercetin	0-9	H3 histone pseudogene 16	Homo sapiens	18-21
19009557-5	2009	Quercetin induced p21 CDK inhibitor with a concomitant decrease of phosphorylation of pRb, which inhibits the G(1)/S cell cycle progression by trapping E2F1.	Quercetin	0-9	RB transcriptional corepressor 1	Homo sapiens	86-89
19009557-8	2009	Inhibition of the recruitment of key transcription factor NF-Y to cyclin B1 gene promoter by quercetin led to transcriptional inhibition.	Quercetin	93-102	cyclin B1	Homo sapiens	66-75
19009557-5	2009	Quercetin induced p21 CDK inhibitor with a concomitant decrease of phosphorylation of pRb, which inhibits the G(1)/S cell cycle progression by trapping E2F1.	Quercetin	0-9	E2F transcription factor 1	Homo sapiens	152-156
18774171-7	2009	However, quercetin prevented PHA-induced PBMC proliferation and SEB-induced upregulation of activation markers.	Quercetin	9-18	SET binding protein 1	Homo sapiens	64-67
19009557-6	2009	A low dose of quercetin induced mild DNA damage and Chk2 activation, which is the main regulator of p21 expression by quercetin.	Quercetin	14-23	checkpoint kinase 2	Homo sapiens	52-56
19009557-6	2009	A low dose of quercetin induced mild DNA damage and Chk2 activation, which is the main regulator of p21 expression by quercetin.	Quercetin	14-23	H3 histone pseudogene 16	Homo sapiens	100-103
19009557-6	2009	A low dose of quercetin induced mild DNA damage and Chk2 activation, which is the main regulator of p21 expression by quercetin.	Quercetin	118-127	checkpoint kinase 2	Homo sapiens	52-56
19009557-6	2009	A low dose of quercetin induced mild DNA damage and Chk2 activation, which is the main regulator of p21 expression by quercetin.	Quercetin	118-127	H3 histone pseudogene 16	Homo sapiens	100-103
19009557-7	2009	In addition, quercetin down-regulated the cyclin B1 and CDK1, essential components of G(2)/M cell cycle progression.	Quercetin	13-22	cyclin B1	Homo sapiens	42-51
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Quercetin	88-97	hematopoietic prostaglandin D synthase	Rattus norvegicus	159-184
19056647-2	2009	In this study, we determined whether quercetin protects against colon cancer by regulating the protein level of phosphatidylinositol 3-kinase (PI 3-kinase) and Akt or by suppressing the expression of proinflammatory mediators [cyclooxygenase (COX)-1, COX-2, inducible nitric oxide synthase (iNOS)] during the aberrant crypt (AC) stage.	Quercetin	37-46	AKT serine/threonine kinase 1	Rattus norvegicus	160-163
19056647-2	2009	In this study, we determined whether quercetin protects against colon cancer by regulating the protein level of phosphatidylinositol 3-kinase (PI 3-kinase) and Akt or by suppressing the expression of proinflammatory mediators [cyclooxygenase (COX)-1, COX-2, inducible nitric oxide synthase (iNOS)] during the aberrant crypt (AC) stage.	Quercetin	37-46	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	227-249
19056647-2	2009	In this study, we determined whether quercetin protects against colon cancer by regulating the protein level of phosphatidylinositol 3-kinase (PI 3-kinase) and Akt or by suppressing the expression of proinflammatory mediators [cyclooxygenase (COX)-1, COX-2, inducible nitric oxide synthase (iNOS)] during the aberrant crypt (AC) stage.	Quercetin	37-46	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	251-256
19056647-2	2009	In this study, we determined whether quercetin protects against colon cancer by regulating the protein level of phosphatidylinositol 3-kinase (PI 3-kinase) and Akt or by suppressing the expression of proinflammatory mediators [cyclooxygenase (COX)-1, COX-2, inducible nitric oxide synthase (iNOS)] during the aberrant crypt (AC) stage.	Quercetin	37-46	nitric oxide synthase 2	Rattus norvegicus	258-289
19056647-2	2009	In this study, we determined whether quercetin protects against colon cancer by regulating the protein level of phosphatidylinositol 3-kinase (PI 3-kinase) and Akt or by suppressing the expression of proinflammatory mediators [cyclooxygenase (COX)-1, COX-2, inducible nitric oxide synthase (iNOS)] during the aberrant crypt (AC) stage.	Quercetin	37-46	nitric oxide synthase 2	Rattus norvegicus	291-295
19056647-9	2009	However, quercetin tended to suppress (P &lt; 0.06) the expression of COX-1 and COX-2.	Quercetin	9-18	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	70-75
19056647-9	2009	However, quercetin tended to suppress (P &lt; 0.06) the expression of COX-1 and COX-2.	Quercetin	9-18	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	80-85
19838948-4	2009	The cell population of sub-G0/G1 phase and the level of annexin V binding were increased synergistically after combination treatment with quercetin and 2-methoxyestradiol in both cell lines.	Quercetin	138-147	annexin A5	Homo sapiens	56-65
19838948-5	2009	Moreover, quercetin combined with 2-methoxyestradiol increased superoxide levels, mitochondrial superoxide dismutase (MnSOD) in mRNA, protein levels, and SOD activity.	Quercetin	10-19	superoxide dismutase 2	Homo sapiens	118-123
19838948-5	2009	Moreover, quercetin combined with 2-methoxyestradiol increased superoxide levels, mitochondrial superoxide dismutase (MnSOD) in mRNA, protein levels, and SOD activity.	Quercetin	10-19	superoxide dismutase 2	Homo sapiens	120-123
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Quercetin	88-97	hematopoietic prostaglandin D synthase	Rattus norvegicus	186-189
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Quercetin	88-97	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	195-227
19838946-3	2009	Therefore, the present study aimed to investigate the in vivo effects of the flavonoids quercetin and catechin on mRNA and activity levels of phase II enzymes glutathione-S transferase (GST) and NAD(P)H quinone oxidoreductase-1 (NQO1) in rat liver.	Quercetin	88-97	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	229-233
19838946-6	2009	Dietary quercetin significantly decreased activity of hepatic GST (24%), whereas dietary catechin significantly decreased NQO1 activity (26%) compared to controls.	Quercetin	8-17	hematopoietic prostaglandin D synthase	Rattus norvegicus	62-65
18980244-0	2008	Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	45-50
18715823-0	2009	Spectrometric and voltammetric studies of the interaction between quercetin and bovine serum albumin using warfarin as site marker with the aid of chemometrics.	Quercetin	66-75	albumin	Homo sapiens	87-100
18715823-1	2009	The interaction of quercetin, which is a bioflavonoid, with bovine serum albumin (BSA) was investigated under pseudo-physiological conditions by the application of UV-vis spectrometry, spectrofluorimetry and cyclic voltammetry (CV).	Quercetin	19-28	albumin	Homo sapiens	67-80
18787224-8	2008	Down-regulation of DvL-2 (an upstream signaling protein in WCP) by siRNA or selective inhibition of beta-catenin using quercetin significantly decreased cell growth in MCL cell lines.	Quercetin	119-128	catenin beta 1	Homo sapiens	100-112
19243898-5	2009	Immunohistochemical analysis showed that quercetin significantly inhibited PCNA, PDGF-BB, b-FGF, and TGF-beta1 expressions in the neointima.	Quercetin	41-50	proliferating cell nuclear antigen	Rattus norvegicus	75-79
19243898-5	2009	Immunohistochemical analysis showed that quercetin significantly inhibited PCNA, PDGF-BB, b-FGF, and TGF-beta1 expressions in the neointima.	Quercetin	41-50	transforming growth factor, beta 1	Rattus norvegicus	101-110
19243898-8	2009	This effect of quercetin might be partially attributed to the suppression of PDGF-BB, b-FGF, and TGF-beta1 expressions.	Quercetin	15-24	transforming growth factor, beta 1	Rattus norvegicus	97-106
18926575-3	2008	Quercetin reduced, in a dose-dependent manner, the proliferation of PBMC and modulated the level of IL-1beta and TNF-alpha released by PBMC in the culture supernatants.	Quercetin	0-9	interleukin 1 beta	Homo sapiens	100-108
18926575-3	2008	Quercetin reduced, in a dose-dependent manner, the proliferation of PBMC and modulated the level of IL-1beta and TNF-alpha released by PBMC in the culture supernatants.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	113-122
18926575-4	2008	Quercetin reduced the MMP-9/TIMP-1 ratio via lowering MMP-9 production.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	22-27
18926575-4	2008	Quercetin reduced the MMP-9/TIMP-1 ratio via lowering MMP-9 production.	Quercetin	0-9	TIMP metallopeptidase inhibitor 1	Homo sapiens	28-34
18926575-4	2008	Quercetin reduced the MMP-9/TIMP-1 ratio via lowering MMP-9 production.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	54-59
18926575-5	2008	Quercetin, when combined with IFN-beta, had additive effects in modulating TNF-alpha and MMP-9.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	75-84
18980244-0	2008	Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation.	Quercetin	0-9	TNF receptor superfamily member 10b	Homo sapiens	86-89
18926575-5	2008	Quercetin, when combined with IFN-beta, had additive effects in modulating TNF-alpha and MMP-9.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	89-94
18980244-0	2008	Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation.	Quercetin	0-9	CASP8 and FADD like apoptosis regulator	Homo sapiens	128-135
18980244-1	2008	This study demonstrates that combined treatment with subtoxic doses of quercetin (3",3",4",5,7-pentahydroxyflavone), a flavonoid found in many fruits and vegetables, plus tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rapid apoptosis in TRAIL-resistant hepatocellular carcinoma (HCC) cells.	Quercetin	71-80	TNF superfamily member 10	Homo sapiens	171-226
18980244-1	2008	This study demonstrates that combined treatment with subtoxic doses of quercetin (3",3",4",5,7-pentahydroxyflavone), a flavonoid found in many fruits and vegetables, plus tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rapid apoptosis in TRAIL-resistant hepatocellular carcinoma (HCC) cells.	Quercetin	71-80	TNF superfamily member 10	Homo sapiens	228-233
18980244-1	2008	This study demonstrates that combined treatment with subtoxic doses of quercetin (3",3",4",5,7-pentahydroxyflavone), a flavonoid found in many fruits and vegetables, plus tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rapid apoptosis in TRAIL-resistant hepatocellular carcinoma (HCC) cells.	Quercetin	71-80	TNF superfamily member 10	Homo sapiens	262-267
18980244-1	2008	This study demonstrates that combined treatment with subtoxic doses of quercetin (3",3",4",5,7-pentahydroxyflavone), a flavonoid found in many fruits and vegetables, plus tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rapid apoptosis in TRAIL-resistant hepatocellular carcinoma (HCC) cells.	Quercetin	82-114	TNF superfamily member 10	Homo sapiens	262-267
18980244-5	2008	We found that quercetin treatment of HCC cells significantly up-regulated the mRNA and protein levels of DR5, a death receptor of TRAIL, in a transcription factor Sp1-dependent manner.	Quercetin	14-23	TNF receptor superfamily member 10b	Homo sapiens	105-108
18980244-5	2008	We found that quercetin treatment of HCC cells significantly up-regulated the mRNA and protein levels of DR5, a death receptor of TRAIL, in a transcription factor Sp1-dependent manner.	Quercetin	14-23	TNF superfamily member 10	Homo sapiens	130-135
18980244-6	2008	Furthermore, treatment with quercetin significantly decreased the protein levels of c-FLIP, an inhibitor of caspase-8, through proteasome-mediated degradation.	Quercetin	28-37	CASP8 and FADD like apoptosis regulator	Homo sapiens	84-90
18980244-6	2008	Furthermore, treatment with quercetin significantly decreased the protein levels of c-FLIP, an inhibitor of caspase-8, through proteasome-mediated degradation.	Quercetin	28-37	caspase 8	Homo sapiens	108-117
18980244-7	2008	Finally, administration of small interfering RNA against DR5 or overexpression of c-FLIPS, but not c-FLIPL, significantly attenuated quercetin-stimulated TRAIL-induced apoptosis.	Quercetin	133-142	TNF receptor superfamily member 10b	Homo sapiens	57-60
18980244-7	2008	Finally, administration of small interfering RNA against DR5 or overexpression of c-FLIPS, but not c-FLIPL, significantly attenuated quercetin-stimulated TRAIL-induced apoptosis.	Quercetin	133-142	CASP8 and FADD like apoptosis regulator	Homo sapiens	82-89
18980244-7	2008	Finally, administration of small interfering RNA against DR5 or overexpression of c-FLIPS, but not c-FLIPL, significantly attenuated quercetin-stimulated TRAIL-induced apoptosis.	Quercetin	133-142	TNF superfamily member 10	Homo sapiens	154-159
18980244-8	2008	Collectively, these findings show that quercetin recovers TRAIL sensitivity in various HCC cells via up-regulation of DR5 and down-regulation of c-FLIPS.	Quercetin	39-48	TNF superfamily member 10	Homo sapiens	58-63
18980244-8	2008	Collectively, these findings show that quercetin recovers TRAIL sensitivity in various HCC cells via up-regulation of DR5 and down-regulation of c-FLIPS.	Quercetin	39-48	TNF receptor superfamily member 10b	Homo sapiens	118-121
18980244-8	2008	Collectively, these findings show that quercetin recovers TRAIL sensitivity in various HCC cells via up-regulation of DR5 and down-regulation of c-FLIPS.	Quercetin	39-48	CASP8 and FADD like apoptosis regulator	Homo sapiens	145-152
18663739-1	2008	Interactions between the anticancer drug quercetin and biodegradable polyesters within micelles were investigated by DSC, WAXD, and UV analyses.	Quercetin	41-50	desmocollin 3	Homo sapiens	117-120
18726985-8	2008	CONCLUSION: Our results demonstrate that quercetin down-regulates the expression of Hsp90 which, in turn, induces inhibition of growth and cell death in prostate cancer cells while exerting no quantifiable effect on normal prostate epithelial cells.	Quercetin	41-50	heat shock protein 90 alpha family class A member 1	Homo sapiens	84-89
18955141-1	2008	This study investigates the importance of the intracellular ratio of the two estrogen receptors ERalpha and ERbeta for the ultimate potential of the phytoestrogens genistein and quercetin to stimulate or inhibit cancer cell proliferation.	Quercetin	178-187	estrogen receptor 1	Homo sapiens	96-103
18955141-1	2008	This study investigates the importance of the intracellular ratio of the two estrogen receptors ERalpha and ERbeta for the ultimate potential of the phytoestrogens genistein and quercetin to stimulate or inhibit cancer cell proliferation.	Quercetin	178-187	estrogen receptor 2	Homo sapiens	108-114
18955141-2	2008	This is of importance because (i) ERbeta has been postulated to play a role in modulating ERalpha-mediated cell proliferation, (ii) genistein and quercetin may be agonists for both receptor types and (iii) the ratio of ERalpha to ERbeta is known to vary between tissues.	Quercetin	146-155	estrogen receptor 1	Homo sapiens	90-97
18955141-2	2008	This is of importance because (i) ERbeta has been postulated to play a role in modulating ERalpha-mediated cell proliferation, (ii) genistein and quercetin may be agonists for both receptor types and (iii) the ratio of ERalpha to ERbeta is known to vary between tissues.	Quercetin	146-155	estrogen receptor 1	Homo sapiens	219-226
18955141-2	2008	This is of importance because (i) ERbeta has been postulated to play a role in modulating ERalpha-mediated cell proliferation, (ii) genistein and quercetin may be agonists for both receptor types and (iii) the ratio of ERalpha to ERbeta is known to vary between tissues.	Quercetin	146-155	estrogen receptor 2	Homo sapiens	230-236
18955141-3	2008	Using human osteosarcoma (U2OS) ERalpha or ERbeta reporter cells it was shown that compared to estradiol (E2), genistein and quercetin have not only a relatively greater preference for ERbeta but also a higher maximal potential for activating ERbeta-mediated gene expression.	Quercetin	125-134	estrogen receptor 1	Homo sapiens	32-39
18955141-3	2008	Using human osteosarcoma (U2OS) ERalpha or ERbeta reporter cells it was shown that compared to estradiol (E2), genistein and quercetin have not only a relatively greater preference for ERbeta but also a higher maximal potential for activating ERbeta-mediated gene expression.	Quercetin	125-134	estrogen receptor 2	Homo sapiens	43-49
18955141-3	2008	Using human osteosarcoma (U2OS) ERalpha or ERbeta reporter cells it was shown that compared to estradiol (E2), genistein and quercetin have not only a relatively greater preference for ERbeta but also a higher maximal potential for activating ERbeta-mediated gene expression.	Quercetin	125-134	estrogen receptor 2	Homo sapiens	185-191
18955141-3	2008	Using human osteosarcoma (U2OS) ERalpha or ERbeta reporter cells it was shown that compared to estradiol (E2), genistein and quercetin have not only a relatively greater preference for ERbeta but also a higher maximal potential for activating ERbeta-mediated gene expression.	Quercetin	125-134	estrogen receptor 2	Homo sapiens	185-191
18726985-5	2008	Furthermore, we demonstrate that quercetin promotes cancer cell apoptosis by down-regulating the levels of heat shock protein (Hsp) 90.	Quercetin	33-42	heat shock protein 90 alpha family class A member 1	Homo sapiens	107-134
18726985-6	2008	Depletion of Hsp90 by quercetin results in decreased cell viability, levels of surrogate markers of Hsp90 inhibition (intracellular and secreted), induced apoptosis and activation of caspases in cancer cells but not in normal prostate epithelial cells.	Quercetin	22-31	heat shock protein 90 alpha family class A member 1	Homo sapiens	13-18
18726985-6	2008	Depletion of Hsp90 by quercetin results in decreased cell viability, levels of surrogate markers of Hsp90 inhibition (intracellular and secreted), induced apoptosis and activation of caspases in cancer cells but not in normal prostate epithelial cells.	Quercetin	22-31	heat shock protein 90 alpha family class A member 1	Homo sapiens	100-105
17869316-4	2008	On the other hand, some flavones such as apigenin, flavonols such as quercetin, and anthraquinones such as emodin, showed notable inhibitory effects on the in vitro activation of AhR induced by the dioxin [2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)].	Quercetin	69-78	aryl hydrocarbon receptor	Homo sapiens	179-182
18980205-14	2008	Chronic administration of quercetin significantly attenuated elevated lipid peroxidation and restored the depleted reduced glutathione, acetylcholinesterase activity and nitrite activity.	Quercetin	26-35	acetylcholinesterase	Rattus norvegicus	136-156
18951251-11	2008	In conclusion, quercetin, naringenin, genistein, and xanthohumol reduced P-gp-mediated transport and increased the basolateral uptake rate of cimetidine.	Quercetin	15-24	ATP binding cassette subfamily B member 1	Homo sapiens	73-77
18948185-7	2008	In conclusion, UVA irradiation combined with BaP synergistically promoted necrosis of A549 cells by increasing intracellular ROS levels, and quercetin prevented BaP-enhanced phototoxicity due to UVA irradiation.	Quercetin	141-150	prohibitin 2	Homo sapiens	161-164
18958418-4	2008	Quercetin caused a remarkable increase in the number of sub-G1 phase cells, and an Annexin-V assay revealed that exposure to quercetin affected apoptosis.	Quercetin	125-134	annexin A5	Homo sapiens	83-92
18930055-0	2008	Inhibitory effects of gallic acid and quercetin on UDP-glucose dehydrogenase activity.	Quercetin	38-47	UDP-glucose 6-dehydrogenase	Homo sapiens	51-76
18930055-2	2008	Gallic acid and quercetin decreased specific activities of UGDH and inhibited the proliferation of MCF-7 human breast cancer cells.	Quercetin	16-25	UDP-glucose 6-dehydrogenase	Homo sapiens	59-63
18930055-6	2008	These results indicate that gallic acid and quercetin are effective inhibitors of UGDH that exert strong antiproliferative activity in breast cancer cells.	Quercetin	44-53	UDP-glucose 6-dehydrogenase	Homo sapiens	82-86
18394220-4	2008	A significantly inhibitory effect of quercetin on VCAM-1 (10-50 micromol/l), ICAM-1 (50 micromol/l) and E-selectin (50 micromol/l) expression was also observed.	Quercetin	37-46	vascular cell adhesion molecule 1	Homo sapiens	50-56
18394220-4	2008	A significantly inhibitory effect of quercetin on VCAM-1 (10-50 micromol/l), ICAM-1 (50 micromol/l) and E-selectin (50 micromol/l) expression was also observed.	Quercetin	37-46	intercellular adhesion molecule 1	Homo sapiens	77-83
18394220-4	2008	A significantly inhibitory effect of quercetin on VCAM-1 (10-50 micromol/l), ICAM-1 (50 micromol/l) and E-selectin (50 micromol/l) expression was also observed.	Quercetin	37-46	selectin E	Homo sapiens	104-114
18394220-6	2008	The inhibitory effect on iNOS and COX-2 protein level was stronger for quercetin at 5-50 micromol/l.	Quercetin	71-80	nitric oxide synthase 2	Homo sapiens	25-29
18394220-8	2008	The present study indicates that differences exist in the modulation of pro-inflammatory genes and in the blockade of NF-kappaB and AP-1 by kaempferol and quercetin.	Quercetin	155-164	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-136
18675775-5	2008	The neurotoxic potential of both quercetin and 2"-glutathionyl-quercetin paralleled their ability to modulate the pro-survival Akt/PKB and extracellular signal-regulated kinase (ERK) signalling pathways.	Quercetin	33-42	mitogen-activated protein kinase 1	Homo sapiens	139-176
18675775-5	2008	The neurotoxic potential of both quercetin and 2"-glutathionyl-quercetin paralleled their ability to modulate the pro-survival Akt/PKB and extracellular signal-regulated kinase (ERK) signalling pathways.	Quercetin	33-42	mitogen-activated protein kinase 1	Homo sapiens	178-181
18842789-0	2008	Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men.	Quercetin	24-33	endothelin 1	Homo sapiens	95-107
18842789-8	2008	Quercetin and (-)-epicatechin resulted in a significant reduction in plasma endothelin-1 concentration (P &lt; 0.05), but only quercetin significantly decreased the urinary endothelin-1 concentration.	Quercetin	0-9	endothelin 1	Homo sapiens	76-88
18842789-8	2008	Quercetin and (-)-epicatechin resulted in a significant reduction in plasma endothelin-1 concentration (P &lt; 0.05), but only quercetin significantly decreased the urinary endothelin-1 concentration.	Quercetin	127-136	endothelin 1	Homo sapiens	173-185
18842789-11	2008	CONCLUSIONS: Dietary flavonoids, such as quercetin and (-)-epicatechin, can augment nitric oxide status and reduce endothelin-1 concentrations and may thereby improve endothelial function.	Quercetin	41-50	endothelin 1	Homo sapiens	115-127
18958418-5	2008	Moreover, treatment with quercetin increased Bax expression but decreased Bcl-2 expression.	Quercetin	25-34	BCL2 associated X, apoptosis regulator	Homo sapiens	45-48
18958418-5	2008	Moreover, treatment with quercetin increased Bax expression but decreased Bcl-2 expression.	Quercetin	25-34	BCL2 apoptosis regulator	Homo sapiens	74-79
18958418-6	2008	Cleaved caspase-3 and PARP expression was also increased by quercetin.	Quercetin	60-69	collagen type XI alpha 2 chain	Homo sapiens	22-26
18655183-0	2008	Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-84
18653741-4	2008	The turnover of 1 was NADPH-dependent and was completely inhibited by ketoconazole and quercetin in the CYP3A4/5 and CYP2C8 incubations, respectively.	Quercetin	87-96	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	104-110
18653741-4	2008	The turnover of 1 was NADPH-dependent and was completely inhibited by ketoconazole and quercetin in the CYP3A4/5 and CYP2C8 incubations, respectively.	Quercetin	87-96	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	117-123
19069845-7	2008	Co-administration of taurine or quercetin normalized creatinine clearance and ameliorated the elevations in urinary proteins, uronic acids, NAG and renal cortical LPOs in GM/DC treated rats.	Quercetin	32-41	O-GlcNAcase	Rattus norvegicus	140-143
18655183-2	2008	In this study, under hypoxic conditions (1% O(2)), we examined the effect of quercetin on the intracellular level of HIF-1alpha and extracellular level of vascular endothelial growth factor (VEGF) in a variety of human cancer cell lines.	Quercetin	77-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
18655183-3	2008	Surprisingly, we observed that quercetin suppressed the HIF-1alpha accumulation during hypoxia in human prostate cancer LNCaP, colon cancer CX-1, and breast cancer SkBr3 cells.	Quercetin	31-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
18655183-0	2008	Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-96
18655183-4	2008	Quercetin treatment also significantly reduced hypoxia-induced secretion of VEGF.	Quercetin	0-9	vascular endothelial growth factor A	Homo sapiens	76-80
18655183-5	2008	Suppression of HIF-1alpha accumulation during treatment with quercetin in hypoxia was not prevented by treatment with 26S proteasome inhibitor MG132 or PI3K inhibitor LY294002.	Quercetin	61-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	15-25
18655183-1	2008	Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells and induce the accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) in normoxia.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	142-173
18655183-6	2008	Interestingly, hypoxia (1% O(2)) in the presence of 100 microM quercetin inhibited protein synthesis by 94% during incubation for 8 h. Significant quercetin concentration-dependent inhibition of protein synthesis and suppression of HIF-1alpha accumulation were observed under hypoxic conditions.	Quercetin	63-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	232-242
18655183-1	2008	Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells and induce the accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) in normoxia.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	175-185
18655183-6	2008	Interestingly, hypoxia (1% O(2)) in the presence of 100 microM quercetin inhibited protein synthesis by 94% during incubation for 8 h. Significant quercetin concentration-dependent inhibition of protein synthesis and suppression of HIF-1alpha accumulation were observed under hypoxic conditions.	Quercetin	147-156	hypoxia inducible factor 1 subunit alpha	Homo sapiens	232-242
18655183-7	2008	Treatment with 100 microM cycloheximide, a protein synthesis inhibitor, replicated the effect of quercetin by inhibiting HIF-1alpha accumulation during hypoxia.	Quercetin	97-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	121-131
18692520-0	2008	Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?	Quercetin	0-9	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	59-65
18655183-8	2008	These results suggest that suppression of HIF-1alpha accumulation during treatment with quercetin under hypoxic conditions is due to inhibition of protein synthesis.	Quercetin	88-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-52
18655187-0	2008	Quercetin-induced ubiquitination and down-regulation of Her-2/neu.	Quercetin	0-9	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-65
18655187-4	2008	In this study, we observed that quercetin decreased the level of Her-2/neu protein in time- and dose-dependent manners and also inhibited the downstream survival PI3K-Akt signaling pathway in Her-2/neu-overexpressing breast cancer SK-Br3 cells.	Quercetin	32-41	erb-b2 receptor tyrosine kinase 2	Homo sapiens	65-74
18655187-4	2008	In this study, we observed that quercetin decreased the level of Her-2/neu protein in time- and dose-dependent manners and also inhibited the downstream survival PI3K-Akt signaling pathway in Her-2/neu-overexpressing breast cancer SK-Br3 cells.	Quercetin	32-41	erb-b2 receptor tyrosine kinase 2	Homo sapiens	192-201
18655187-5	2008	We also observed that quercetin induced polyubiquitination of Her-2/neu.	Quercetin	22-31	erb-b2 receptor tyrosine kinase 2	Homo sapiens	62-71
18655187-6	2008	When the proteasome pathway was blocked by MG-132 during quercetin treatment, accumulation of the NP-40 insoluble form of Her-2/neu occurred.	Quercetin	57-66	erb-b2 receptor tyrosine kinase 2	Homo sapiens	122-131
18655187-7	2008	Interestingly, data from immunocomplex studies revealed that quercetin promoted interaction between Her-2/neu and Hsp90 which is a molecular chaperone involved in stabilization of Her-2/neu.	Quercetin	61-70	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-109
18655187-7	2008	Interestingly, data from immunocomplex studies revealed that quercetin promoted interaction between Her-2/neu and Hsp90 which is a molecular chaperone involved in stabilization of Her-2/neu.	Quercetin	61-70	heat shock protein 90 alpha family class A member 1	Homo sapiens	114-119
18655187-7	2008	Interestingly, data from immunocomplex studies revealed that quercetin promoted interaction between Her-2/neu and Hsp90 which is a molecular chaperone involved in stabilization of Her-2/neu.	Quercetin	61-70	erb-b2 receptor tyrosine kinase 2	Homo sapiens	180-189
18655187-9	2008	In addition, the carboxyl terminus of Hsc70-interacting protein (CHIP), a chaperone-dependent E3 ubiquitin ligase, played a crucial role in the quercetin-induced ubiquitination of Her-2/neu.	Quercetin	144-153	ST13 Hsp70 interacting protein	Homo sapiens	38-63
18655187-9	2008	In addition, the carboxyl terminus of Hsc70-interacting protein (CHIP), a chaperone-dependent E3 ubiquitin ligase, played a crucial role in the quercetin-induced ubiquitination of Her-2/neu.	Quercetin	144-153	erb-b2 receptor tyrosine kinase 2	Homo sapiens	180-189
18655187-10	2008	Inhibition of tyrosine kinase activity of Her-2/neu by quercetin could indicate an lateration in the Her-2/neu structure which promotes CHIP recruitments and down-regulation of Her-2/neu.	Quercetin	55-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-51
18655187-10	2008	Inhibition of tyrosine kinase activity of Her-2/neu by quercetin could indicate an lateration in the Her-2/neu structure which promotes CHIP recruitments and down-regulation of Her-2/neu.	Quercetin	55-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-47
18655187-10	2008	Inhibition of tyrosine kinase activity of Her-2/neu by quercetin could indicate an lateration in the Her-2/neu structure which promotes CHIP recruitments and down-regulation of Her-2/neu.	Quercetin	55-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	48-51
18655187-10	2008	Inhibition of tyrosine kinase activity of Her-2/neu by quercetin could indicate an lateration in the Her-2/neu structure which promotes CHIP recruitments and down-regulation of Her-2/neu.	Quercetin	55-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	101-110
18655187-11	2008	We believe that by using quercetin, new therapeutic strategies can be developed to treat Her-2/neu overexpressing cancers.	Quercetin	25-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	89-94
18655187-11	2008	We believe that by using quercetin, new therapeutic strategies can be developed to treat Her-2/neu overexpressing cancers.	Quercetin	25-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	95-98
18692520-3	2008	However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%.	Quercetin	63-72	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	20-26
18692520-4	2008	Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress.	Quercetin	13-22	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	31-37
18813348-6	2008	Suppression of Hsf1 in A1-5 cells with quercetin or an Hsf1 siRNA reduced p53 nuclear importation and inhibited p53-mediated activation of a p21 reporter.	Quercetin	39-48	heat shock transcription factor 1	Homo sapiens	15-19
18813348-6	2008	Suppression of Hsf1 in A1-5 cells with quercetin or an Hsf1 siRNA reduced p53 nuclear importation and inhibited p53-mediated activation of a p21 reporter.	Quercetin	39-48	tumor protein p53	Homo sapiens	74-77
18813348-6	2008	Suppression of Hsf1 in A1-5 cells with quercetin or an Hsf1 siRNA reduced p53 nuclear importation and inhibited p53-mediated activation of a p21 reporter.	Quercetin	39-48	H3 histone pseudogene 16	Homo sapiens	141-144
18639531-4	2008	The metabolite quercetin 3-glucuronide caused a significant reduction in fMLP-evoked calcium influx in human neutrophils (approximately 35%), while neither quercetin 3"-sulfate nor quercetin produced a similar change.	Quercetin	15-24	formyl peptide receptor 1	Homo sapiens	73-77
18681440-7	2008	Moreover, chamomile extract showed potent inhibition against aldose reductase (ALR2), with an IC50 value of 16.9 microg/mL, and its components, umbelliferone (1), esculetin (3), luteolin (6), and quercetin (7), could significantly inhibit the accumulation of sorbitol in human erythrocytes.	Quercetin	196-205	aldo-keto reductase family 1 member B	Homo sapiens	79-83
18586010-0	2008	The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways.	Quercetin	27-36	mitogen-activated protein kinase 1	Mus musculus	65-69
18586010-5	2008	Treatment of 3T3-L1 adipocytes with quercetin resulted in the induction of apoptosis and a concomitant decrease in ERK and JNK phosphorylation.	Quercetin	36-45	mitogen-activated protein kinase 1	Mus musculus	115-118
18586010-5	2008	Treatment of 3T3-L1 adipocytes with quercetin resulted in the induction of apoptosis and a concomitant decrease in ERK and JNK phosphorylation.	Quercetin	36-45	mitogen-activated protein kinase 8	Mus musculus	123-126
18586010-6	2008	Taken together, these data indicate that quercetin exerts anti-adipogenesis activity by activating the AMPK signal pathway in 3T3-L1 preadipocytes, while the quercetin-induced apoptosis of mature adipocytes was mediated by modulation of the ERK and JNK pathways, which play pivotal roles during apoptosis.	Quercetin	41-50	mitogen-activated protein kinase 1	Mus musculus	241-244
18586010-6	2008	Taken together, these data indicate that quercetin exerts anti-adipogenesis activity by activating the AMPK signal pathway in 3T3-L1 preadipocytes, while the quercetin-induced apoptosis of mature adipocytes was mediated by modulation of the ERK and JNK pathways, which play pivotal roles during apoptosis.	Quercetin	41-50	mitogen-activated protein kinase 8	Mus musculus	249-252
18586010-6	2008	Taken together, these data indicate that quercetin exerts anti-adipogenesis activity by activating the AMPK signal pathway in 3T3-L1 preadipocytes, while the quercetin-induced apoptosis of mature adipocytes was mediated by modulation of the ERK and JNK pathways, which play pivotal roles during apoptosis.	Quercetin	158-167	mitogen-activated protein kinase 1	Mus musculus	241-244
18586010-6	2008	Taken together, these data indicate that quercetin exerts anti-adipogenesis activity by activating the AMPK signal pathway in 3T3-L1 preadipocytes, while the quercetin-induced apoptosis of mature adipocytes was mediated by modulation of the ERK and JNK pathways, which play pivotal roles during apoptosis.	Quercetin	158-167	mitogen-activated protein kinase 8	Mus musculus	249-252
18628248-0	2008	Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.	Quercetin	0-9	protein kinase C delta	Homo sapiens	55-64
18392951-4	2008	The inducing effects of bicyclol on HSP27, HSP70 and HSF1 were all blocked by quercetin, an inhibitor of HSP biosynthesis.	Quercetin	78-87	heat shock protein 1	Mus musculus	36-41
18392951-4	2008	The inducing effects of bicyclol on HSP27, HSP70 and HSF1 were all blocked by quercetin, an inhibitor of HSP biosynthesis.	Quercetin	78-87	heat shock protein 1B	Mus musculus	43-48
18392951-4	2008	The inducing effects of bicyclol on HSP27, HSP70 and HSF1 were all blocked by quercetin, an inhibitor of HSP biosynthesis.	Quercetin	78-87	heat shock factor 1	Mus musculus	53-57
18628248-0	2008	Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	65-68
18628248-0	2008	Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.	Quercetin	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-73
18628248-0	2008	Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	84-110
18628248-2	2008	Increases in the protein, messenger RNA and enzyme activity levels of matrix metalloproteinase (MMP)-9 were observed in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells, and these were blocked by QUE, but not by quercitrin or rutin.	Quercetin	210-213	matrix metallopeptidase 9	Homo sapiens	70-102
18800893-14	2008	Biochemically, quercetin treatment attenuated malondialdehyde accumulation and nitrite activity and restored the depleted reduced glutathione and catalase activity.	Quercetin	15-24	catalase	Mus musculus	146-154
18559486-9	2008	Stimulation with 3-methylcholanthrene and rifampicin markedly increased CYP1A1/2 or CYP3A4 activities, which could be selectively inhibited by nifedipine, verapamil, ketoconazole, and quercetin.	Quercetin	184-193	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	72-78
18559486-9	2008	Stimulation with 3-methylcholanthrene and rifampicin markedly increased CYP1A1/2 or CYP3A4 activities, which could be selectively inhibited by nifedipine, verapamil, ketoconazole, and quercetin.	Quercetin	184-193	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-90
18602965-8	2008	A potential pro-apoptotic quercetin action was determined using the FITC-Annexin V kit.	Quercetin	26-35	annexin A5	Rattus norvegicus	73-82
18602965-12	2008	Treatment with quercetin dose-dependently upregulated the expression of HO-1 mRNA in the bone marrow cells.	Quercetin	15-24	heme oxygenase 1	Rattus norvegicus	72-76
18645237-4	2008	In the course of the study of substrate specificity, crystals of DFR-NADP(+)-flavonol (myricetin and quercetin) complexes were obtained.	Quercetin	101-110	dihydroflavonol 4-reductase	Vitis vinifera	65-68
18551111-9	2008	Furthermore, chronic intake of the higher dose of quercetin enhanced VAT eNOS expression among obese Zucker rats, whereas it downregulated VAT iNOS expression.	Quercetin	50-59	solute carrier family 18 member A3	Rattus norvegicus	69-77
18551111-9	2008	Furthermore, chronic intake of the higher dose of quercetin enhanced VAT eNOS expression among obese Zucker rats, whereas it downregulated VAT iNOS expression.	Quercetin	50-59	solute carrier family 18 member A3	Rattus norvegicus	69-72
18551111-9	2008	Furthermore, chronic intake of the higher dose of quercetin enhanced VAT eNOS expression among obese Zucker rats, whereas it downregulated VAT iNOS expression.	Quercetin	50-59	nitric oxide synthase 2	Rattus norvegicus	143-147
18551111-10	2008	In conclusion, both doses of quercetin improved dyslipidemia, hypertension, and hyperinsulinemia in obese Zucker rats, but only the high dose produced antiinflammatory effects in VAT together with a reduction in body weight gain.	Quercetin	29-38	solute carrier family 18 member A3	Rattus norvegicus	179-182
18590707-6	2008	Inducible nitric oxide synthase expression was also blocked largely by some flavonoids, especially quercetin, luteolin and apigenin, while cyclooxygenase 2 was downregulated only by apigenin, diosmetin and quercetin.	Quercetin	99-108	nitric oxide synthase 2	Rattus norvegicus	0-31
18590707-6	2008	Inducible nitric oxide synthase expression was also blocked largely by some flavonoids, especially quercetin, luteolin and apigenin, while cyclooxygenase 2 was downregulated only by apigenin, diosmetin and quercetin.	Quercetin	206-215	nitric oxide synthase 2	Rattus norvegicus	0-31
18590707-6	2008	Inducible nitric oxide synthase expression was also blocked largely by some flavonoids, especially quercetin, luteolin and apigenin, while cyclooxygenase 2 was downregulated only by apigenin, diosmetin and quercetin.	Quercetin	206-215	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	139-155
18619980-6	2008	In the apical-to-basolateral transport, quercetin showed the highest absorptive permeability enhancement and P-gp interaction potential making it an appropriate candidate for further in vivo studies in female Wistar rats.	Quercetin	40-49	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	109-113
18620432-6	2008	Spectrometric analysis indicated that quercetin might act as a cosubstrate of MPO resulting in the formation of the oxidized quercetin.	Quercetin	38-47	myeloperoxidase	Homo sapiens	78-81
18620432-6	2008	Spectrometric analysis indicated that quercetin might act as a cosubstrate of MPO resulting in the formation of the oxidized quercetin.	Quercetin	125-134	myeloperoxidase	Homo sapiens	78-81
18620432-3	2008	In this study, we examined the molecular basis of the inhibitory effects of dietary flavonoids, such as quercetin, and their metabolites on the catalytic reaction of MPO using a combination of biological assays and theoretical calculation studies.	Quercetin	104-113	myeloperoxidase	Homo sapiens	166-169
18620432-9	2008	The binding of quercetin and the metabolites to a hydrophobic region at the entrance to the distal heme pocket of MPO was also proposed by a computer docking simulation.	Quercetin	15-24	myeloperoxidase	Homo sapiens	114-117
18620432-4	2008	Immunohistochemical staining showed that a quercetin metabolite was colocalized with macrophages, MPO, and dityrosine, an MPO-derived oxidation product of tyrosine, in human atherosclerotic aorta.	Quercetin	43-52	myeloperoxidase	Homo sapiens	98-101
18620432-4	2008	Immunohistochemical staining showed that a quercetin metabolite was colocalized with macrophages, MPO, and dityrosine, an MPO-derived oxidation product of tyrosine, in human atherosclerotic aorta.	Quercetin	43-52	myeloperoxidase	Homo sapiens	122-125
18625009-2	2008	Quercetin and luteolin, which differ by one hydroxyl group, are known to suppress the lipopolysaccharide-induced production of TNF-alpha in vitro.	Quercetin	0-9	tumor necrosis factor	Mus musculus	127-136
18620432-5	2008	Quercetin and the plasma metabolites inhibited the formation of dityrosine catalyzed by the MPO enzyme and HL-60 cells in a dose-dependent manner.	Quercetin	0-9	myeloperoxidase	Homo sapiens	92-95
18573104-5	2008	The recombinant MdPGT1 enzyme expressed in Escherichia coli glycosylated phloretin in the presence of [(3)H]-UDP-glucose, but not other apple antioxidants, including quercetin, naringenin and cyanidin.	Quercetin	166-175	phloretin 2'-O-glucosyltransferase	Malus domestica	16-22
18625009-4	2008	In a time- and dose-dependent manner, quercetin reduced the plasma levels of TNF-alpha, lowered bacterial titers in livers, prevented liver damage and prolonged survival, while luteolin had little or no effect.	Quercetin	38-47	tumor necrosis factor	Mus musculus	77-86
18608579-1	2008	PURPOSE: Quercetin (QCT), an important flavonol, is known to sensitize tumour cells to hyperthermia by suppressing heat shock protein 72 (Hsp72) induction, and is also reported to inhibit p53 accumulation.	Quercetin	9-18	heat shock protein family A (Hsp70) member 1A	Homo sapiens	115-136
18608579-1	2008	PURPOSE: Quercetin (QCT), an important flavonol, is known to sensitize tumour cells to hyperthermia by suppressing heat shock protein 72 (Hsp72) induction, and is also reported to inhibit p53 accumulation.	Quercetin	9-18	heat shock protein family A (Hsp70) member 1A	Homo sapiens	138-143
18608579-1	2008	PURPOSE: Quercetin (QCT), an important flavonol, is known to sensitize tumour cells to hyperthermia by suppressing heat shock protein 72 (Hsp72) induction, and is also reported to inhibit p53 accumulation.	Quercetin	9-18	tumor protein p53	Homo sapiens	188-191
18624906-7	2008	By contrast, down-regulating the pathway using Dickkopf-1 or quercetin decreased p-gp expression.	Quercetin	61-70	ATP binding cassette subfamily B member 1	Homo sapiens	81-85
18757557-6	2008	Recombinant UGT78D3 protein could convert quercetin to quercetin 3-O-arabinoside.	Quercetin	42-51	UDP-glucosyl transferase 78D3	Arabidopsis thaliana	12-19
18586279-0	2008	Possible use of quercetin, an antioxidant, for protection of cells suffering from overload of intracellular Ca2+: a model experiment.	Quercetin	16-25	carbonic anhydrase 2	Rattus norvegicus	108-111
18591783-6	2008	Apigenin, luteolin, kaempferol, quercetin and fisetin also appeared to inhibit insulin-stimulated activation of Akt, a pivotal downstream effector of phosphatidylinositol 3-kinase (PI3K), and suppressed insulin-dependent translocation of a glucose transporter, (GLUT)4, into the plasma membrane.	Quercetin	32-41	thymoma viral proto-oncogene 1	Mus musculus	112-115
18468581-0	2008	Regulatory mechanisms of IL-2 and IFNgamma suppression by quercetin in T helper cells.	Quercetin	58-67	interleukin 2	Rattus norvegicus	25-29
18468581-0	2008	Regulatory mechanisms of IL-2 and IFNgamma suppression by quercetin in T helper cells.	Quercetin	58-67	interleukin 18	Rattus norvegicus	34-42
18468581-6	2008	Here, we studied the function of quercetin in Th cells and found that quercetin suppressed both IFNgamma and IL-2 production upon T cell receptor stimulation.	Quercetin	33-42	interleukin 18	Rattus norvegicus	96-104
18468581-6	2008	Here, we studied the function of quercetin in Th cells and found that quercetin suppressed both IFNgamma and IL-2 production upon T cell receptor stimulation.	Quercetin	33-42	interleukin 2	Rattus norvegicus	109-113
18468581-6	2008	Here, we studied the function of quercetin in Th cells and found that quercetin suppressed both IFNgamma and IL-2 production upon T cell receptor stimulation.	Quercetin	70-79	interleukin 18	Rattus norvegicus	96-104
18468581-6	2008	Here, we studied the function of quercetin in Th cells and found that quercetin suppressed both IFNgamma and IL-2 production upon T cell receptor stimulation.	Quercetin	70-79	interleukin 2	Rattus norvegicus	109-113
18468581-8	2008	The fact that quercetin-derived IFNgamma suppression was blocked in T-bet-deficient Th cells demonstrated quercetin act through the modulation of T-bet expression.	Quercetin	14-23	interleukin 18	Rattus norvegicus	32-40
18468581-8	2008	The fact that quercetin-derived IFNgamma suppression was blocked in T-bet-deficient Th cells demonstrated quercetin act through the modulation of T-bet expression.	Quercetin	106-115	interleukin 18	Rattus norvegicus	32-40
18468581-9	2008	Whereas IL-2 inhibition by quercetin was independent of T-bet expression, quercetin diminished IL-2R alpha expression, which is critical for positive regulatory loop of IL-2 autoactivation.	Quercetin	27-36	interleukin 2	Rattus norvegicus	8-12
18468581-9	2008	Whereas IL-2 inhibition by quercetin was independent of T-bet expression, quercetin diminished IL-2R alpha expression, which is critical for positive regulatory loop of IL-2 autoactivation.	Quercetin	74-83	interleukin 2 receptor subunit alpha	Rattus norvegicus	95-106
18468581-9	2008	Whereas IL-2 inhibition by quercetin was independent of T-bet expression, quercetin diminished IL-2R alpha expression, which is critical for positive regulatory loop of IL-2 autoactivation.	Quercetin	74-83	interleukin 2	Rattus norvegicus	95-99
18468581-10	2008	Taken together, quercetin is suggested to repress both IFNgamma and IL-2 cytokine production by independent mechanisms; T-bet-dependent IFNgamma suppression and IL-2R alpha-dependent IL-2 inhibition.	Quercetin	16-25	interleukin 18	Rattus norvegicus	55-63
18468581-10	2008	Taken together, quercetin is suggested to repress both IFNgamma and IL-2 cytokine production by independent mechanisms; T-bet-dependent IFNgamma suppression and IL-2R alpha-dependent IL-2 inhibition.	Quercetin	16-25	interleukin 2	Rattus norvegicus	68-72
18468581-10	2008	Taken together, quercetin is suggested to repress both IFNgamma and IL-2 cytokine production by independent mechanisms; T-bet-dependent IFNgamma suppression and IL-2R alpha-dependent IL-2 inhibition.	Quercetin	16-25	interleukin 18	Rattus norvegicus	136-144
18468581-10	2008	Taken together, quercetin is suggested to repress both IFNgamma and IL-2 cytokine production by independent mechanisms; T-bet-dependent IFNgamma suppression and IL-2R alpha-dependent IL-2 inhibition.	Quercetin	16-25	interleukin 2 receptor subunit alpha	Rattus norvegicus	161-172
18468581-10	2008	Taken together, quercetin is suggested to repress both IFNgamma and IL-2 cytokine production by independent mechanisms; T-bet-dependent IFNgamma suppression and IL-2R alpha-dependent IL-2 inhibition.	Quercetin	16-25	interleukin 2	Rattus norvegicus	161-165
18456009-3	2008	Two natural occurring polyphenolic compounds, representative of glycosylated and unglycosylated flavonoid structures, namely quercetin and rutin, were thereby tested as potential ligands of plasmin(ogen), a serine (pro)protease, whose role in tumor cell invasion and migration has been reported.	Quercetin	125-134	plasminogen	Homo sapiens	190-197
18456009-4	2008	Quercetin showed a ten folds higher affinity with plasmin with respect to rutin in terms of equilibrium dissociation constant, both compounds acting as in vitro moderate reversible inhibitors; additionally, quercetin and rutin prevented plasmin-incubated BB1 cells from releasing E-cadherin fragment to a different extent, respectively.	Quercetin	0-9	plasminogen	Homo sapiens	50-57
18456009-4	2008	Quercetin showed a ten folds higher affinity with plasmin with respect to rutin in terms of equilibrium dissociation constant, both compounds acting as in vitro moderate reversible inhibitors; additionally, quercetin and rutin prevented plasmin-incubated BB1 cells from releasing E-cadherin fragment to a different extent, respectively.	Quercetin	0-9	plasminogen	Homo sapiens	237-244
18456009-4	2008	Quercetin showed a ten folds higher affinity with plasmin with respect to rutin in terms of equilibrium dissociation constant, both compounds acting as in vitro moderate reversible inhibitors; additionally, quercetin and rutin prevented plasmin-incubated BB1 cells from releasing E-cadherin fragment to a different extent, respectively.	Quercetin	0-9	cadherin 1	Homo sapiens	280-290
18456009-4	2008	Quercetin showed a ten folds higher affinity with plasmin with respect to rutin in terms of equilibrium dissociation constant, both compounds acting as in vitro moderate reversible inhibitors; additionally, quercetin and rutin prevented plasmin-incubated BB1 cells from releasing E-cadherin fragment to a different extent, respectively.	Quercetin	207-216	plasminogen	Homo sapiens	50-57
18456009-4	2008	Quercetin showed a ten folds higher affinity with plasmin with respect to rutin in terms of equilibrium dissociation constant, both compounds acting as in vitro moderate reversible inhibitors; additionally, quercetin and rutin prevented plasmin-incubated BB1 cells from releasing E-cadherin fragment to a different extent, respectively.	Quercetin	207-216	plasminogen	Homo sapiens	237-244
18456009-4	2008	Quercetin showed a ten folds higher affinity with plasmin with respect to rutin in terms of equilibrium dissociation constant, both compounds acting as in vitro moderate reversible inhibitors; additionally, quercetin and rutin prevented plasmin-incubated BB1 cells from releasing E-cadherin fragment to a different extent, respectively.	Quercetin	207-216	cadherin 1	Homo sapiens	280-290
18603770-0	2008	Quercetin regulates the inhibitory effect of monoclonal non-specific suppressor factor beta on tumor necrosis factor-alpha production in LPS-stimulated macrophages.	Quercetin	0-9	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	Mus musculus	45-91
18603770-3	2008	In this study, we found evidence that the flavonol quercetin regulates the effect of MNSFbeta on TNFalpha production in LPS-stimulated Raw264.7 cells.	Quercetin	51-60	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	Mus musculus	85-93
18603770-3	2008	In this study, we found evidence that the flavonol quercetin regulates the effect of MNSFbeta on TNFalpha production in LPS-stimulated Raw264.7 cells.	Quercetin	51-60	tumor necrosis factor	Mus musculus	97-105
18603770-4	2008	Quercetin inhibited MNSFbeta siRNA-mediated enhancement of both TNFalpha production and ERK1/2 phosphorylation in LPS-stimulated Raw264.7 cells.	Quercetin	0-9	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	Mus musculus	20-28
18603770-4	2008	Quercetin inhibited MNSFbeta siRNA-mediated enhancement of both TNFalpha production and ERK1/2 phosphorylation in LPS-stimulated Raw264.7 cells.	Quercetin	0-9	tumor necrosis factor	Mus musculus	64-72
18603770-4	2008	Quercetin inhibited MNSFbeta siRNA-mediated enhancement of both TNFalpha production and ERK1/2 phosphorylation in LPS-stimulated Raw264.7 cells.	Quercetin	0-9	mitogen-activated protein kinase 3	Mus musculus	88-94
18603770-5	2008	Quercetin decreased the expression of 33.5-kDa MNSFbeta adduct, which is important to the regulation of ERK1/2 activity, in unstimulated Raw264.7 cells.	Quercetin	0-9	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	Mus musculus	47-55
18603770-5	2008	Quercetin decreased the expression of 33.5-kDa MNSFbeta adduct, which is important to the regulation of ERK1/2 activity, in unstimulated Raw264.7 cells.	Quercetin	0-9	mitogen-activated protein kinase 3	Mus musculus	104-110
18603770-7	2008	Collectively, MNSFbeta and quercetin might share a common pathway in regulating the ERK1/2 pathway in macrophages.	Quercetin	27-36	mitogen-activated protein kinase 3	Mus musculus	84-90
18591783-6	2008	Apigenin, luteolin, kaempferol, quercetin and fisetin also appeared to inhibit insulin-stimulated activation of Akt, a pivotal downstream effector of phosphatidylinositol 3-kinase (PI3K), and suppressed insulin-dependent translocation of a glucose transporter, (GLUT)4, into the plasma membrane.	Quercetin	32-41	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	150-179
18591783-6	2008	Apigenin, luteolin, kaempferol, quercetin and fisetin also appeared to inhibit insulin-stimulated activation of Akt, a pivotal downstream effector of phosphatidylinositol 3-kinase (PI3K), and suppressed insulin-dependent translocation of a glucose transporter, (GLUT)4, into the plasma membrane.	Quercetin	32-41	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	203-268
18831918-4	2008	We recently showed that the natural flavonoids quercetin and luteolin can eliminate "flush", as well as inhibit both niacin-induced plasma prostaglandin D2 (PGD2) and serotonin increase in an animal model.	Quercetin	47-56	prostaglandin D2 synthase	Homo sapiens	139-155
18618485-0	2008	Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.	Quercetin	27-36	epidermal growth factor receptor	Homo sapiens	93-97
18618485-0	2008	Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.	Quercetin	27-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	106-111
18618485-4	2008	Their potency to suppress the ErbB2 receptor phosphorylation can be summarised as delphinidin &gt; EGCG &gt; quercetin.	Quercetin	109-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	30-35
18618485-1	2008	In the present study, delphinidin was found to suppress the phosphorylation of the epidermal growth factor receptor (EGFR) within human tumour cells (human colon carcinoma cell line (HT29), human vulva carcinoma cell line (A431)), albeit less effective than the flavonol quercetin.	Quercetin	271-280	epidermal growth factor receptor	Homo sapiens	83-115
18618485-1	2008	In the present study, delphinidin was found to suppress the phosphorylation of the epidermal growth factor receptor (EGFR) within human tumour cells (human colon carcinoma cell line (HT29), human vulva carcinoma cell line (A431)), albeit less effective than the flavonol quercetin.	Quercetin	271-280	epidermal growth factor receptor	Homo sapiens	117-121
18618485-3	2008	In addition, delphinidin, quercetin and (-)-epigallocatechin-3-gallate (EGCG) were found to suppress the phosphorylation of the ErbB2 receptor, with delphinidin exhibiting the strongest inhibitory properties.	Quercetin	26-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	128-133
18467451-2	2008	This apparent redundancy suggests the possibility that Arabidopsis uses multiple isoforms of FLS with different substrate specificities to mediate the production of the flavonols, quercetin and kaempferol, in a tissue-specific and inducible manner.	Quercetin	180-189	flavonol synthase 1	Arabidopsis thaliana	93-96
18449627-4	2008	We also characterized CBR1 inhibition by the related flavonoids triHER and quercetin.	Quercetin	75-84	carbonyl reductase 1	Homo sapiens	22-26
18455702-0	2008	Role of Bax in quercetin-induced apoptosis in human prostate cancer cells.	Quercetin	15-24	BCL2 associated X, apoptosis regulator	Homo sapiens	8-11
18455702-3	2008	A sustained inhibition of the major survival signal, Akt, occurred in quercetin-treated cells.	Quercetin	70-79	AKT serine/threonine kinase 1	Homo sapiens	53-56
18455702-7	2008	Our results also show that quercetin decreases the Bcl-xL:Bax ratio and increases translocation and multimerization of Bax to the mitochondrial membrane.	Quercetin	27-36	BCL2 like 1	Homo sapiens	51-57
18455702-7	2008	Our results also show that quercetin decreases the Bcl-xL:Bax ratio and increases translocation and multimerization of Bax to the mitochondrial membrane.	Quercetin	27-36	BCL2 associated X, apoptosis regulator	Homo sapiens	58-61
18455702-4	2008	Treatment of LNCaP cells with an apoptosis inducing concentration of quercetin (100 microM) resulted in a rapid decrease in the inhibitory Ser473 phosphorylation of Akt leading to inhibition of its kinase activity.	Quercetin	69-78	AKT serine/threonine kinase 1	Homo sapiens	165-168
18455702-7	2008	Our results also show that quercetin decreases the Bcl-xL:Bax ratio and increases translocation and multimerization of Bax to the mitochondrial membrane.	Quercetin	27-36	BCL2 associated X, apoptosis regulator	Homo sapiens	119-122
18455702-11	2008	Our results indicate that the apoptotic processes caused by quercetin are mediated by the dissociation of Bax from Bcl-xL and the activation of caspase families in human prostate cancer cells.	Quercetin	60-69	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
18455702-5	2008	Quercetin treatment (100 microM) also caused a decrease in Ser136 phosphorylation of Bad, which is a downstream target of Akt.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	122-125
18455702-11	2008	Our results indicate that the apoptotic processes caused by quercetin are mediated by the dissociation of Bax from Bcl-xL and the activation of caspase families in human prostate cancer cells.	Quercetin	60-69	BCL2 like 1	Homo sapiens	115-121
18455702-6	2008	Protein interaction assay revealed that during treatment with quercetin, Bcl-xL dissociated from Bax and then associated with Bad.	Quercetin	62-71	BCL2 like 1	Homo sapiens	73-79
18455702-6	2008	Protein interaction assay revealed that during treatment with quercetin, Bcl-xL dissociated from Bax and then associated with Bad.	Quercetin	62-71	BCL2 associated X, apoptosis regulator	Homo sapiens	97-100
18563345-0	2008	Effect of quercetin on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells.	Quercetin	10-19	nescient helix-loop-helix 1	Homo sapiens	85-89
18346843-0	2008	Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells.	Quercetin	15-24	colony stimulating factor 2	Homo sapiens	35-83
18346843-3	2008	Here, we studied the effects of kaempferol (K) and quercetin (Q) on the production of GM-CSF in PC-3 cells.	Quercetin	51-60	colony stimulating factor 2	Homo sapiens	86-92
18322795-7	2008	Western blot analysis showed that quercetin treatment caused rapid reduction in phosphorylation of extracellular signal-regulated kinase (ERK) and Akt.	Quercetin	34-43	mitogen-activated protein kinase 1	Homo sapiens	99-136
18322795-7	2008	Western blot analysis showed that quercetin treatment caused rapid reduction in phosphorylation of extracellular signal-regulated kinase (ERK) and Akt.	Quercetin	34-43	mitogen-activated protein kinase 1	Homo sapiens	138-141
18322795-7	2008	Western blot analysis showed that quercetin treatment caused rapid reduction in phosphorylation of extracellular signal-regulated kinase (ERK) and Akt.	Quercetin	34-43	AKT serine/threonine kinase 1	Homo sapiens	147-150
18322795-8	2008	Transient transfection with constitutively active forms of MEK and Akt protected against the quercetin-induced loss of cell viability.	Quercetin	93-102	mitogen-activated protein kinase kinase 7	Homo sapiens	59-62
18322795-8	2008	Transient transfection with constitutively active forms of MEK and Akt protected against the quercetin-induced loss of cell viability.	Quercetin	93-102	AKT serine/threonine kinase 1	Homo sapiens	67-70
18322795-12	2008	Taken together, these findings suggest that quercetin results in human glioma cell death through caspase-dependent mechanisms involving down-regulation of ERK, Akt, and survivin.	Quercetin	44-53	mitogen-activated protein kinase 1	Homo sapiens	155-158
18492835-0	2008	Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells.	Quercetin	0-9	claudin 4	Homo sapiens	61-70
18492835-9	2008	Parallel to the R(t) increase, quercetin induced a strong increase of the TJ protein claudin-4 but not of other claudins.	Quercetin	31-40	claudin 4	Homo sapiens	85-94
18492835-13	2008	Reporter gene assays revealed a stimulatory effect of quercetin on claudin-4 transcription.	Quercetin	54-63	claudin 4	Homo sapiens	67-76
18492835-14	2008	The flavonoid quercetin enhances barrier function via transcriptional expression regulation of the TJ protein claudin-4, which represents an important protective effect of this food component against barrier disturbance in intestinal inflammation.	Quercetin	14-23	claudin 4	Homo sapiens	110-119
18419748-0	2008	Quercetin induced tissue-type plasminogen activator expression is mediated through Sp1 and p38 mitogen-activated protein kinase in human endothelial cells.	Quercetin	0-9	plasminogen activator, tissue type	Homo sapiens	18-51
18419748-0	2008	Quercetin induced tissue-type plasminogen activator expression is mediated through Sp1 and p38 mitogen-activated protein kinase in human endothelial cells.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	91-127
18419748-1	2008	BACKGROUND: Wine polyphenol quercetin upregulates tissue-type plasminogen activator (t-PA) transcription in cultured human umbilical cord vein endothelial cells (HUVECs).	Quercetin	28-37	plasminogen activator, tissue type	Homo sapiens	50-83
18419748-1	2008	BACKGROUND: Wine polyphenol quercetin upregulates tissue-type plasminogen activator (t-PA) transcription in cultured human umbilical cord vein endothelial cells (HUVECs).	Quercetin	28-37	plasminogen activator, tissue type	Homo sapiens	85-89
18419748-3	2008	OBJECTIVES: We aimed to localize quercetin-responsive t-PA promoter elements, identify the proteins that bind these elements, and decipher signaling pathways involved in the regulation of t-PA.	Quercetin	33-42	plasminogen activator, tissue type	Homo sapiens	54-58
18419748-3	2008	OBJECTIVES: We aimed to localize quercetin-responsive t-PA promoter elements, identify the proteins that bind these elements, and decipher signaling pathways involved in the regulation of t-PA.	Quercetin	33-42	plasminogen activator, tissue type	Homo sapiens	188-192
18419748-10	2008	RESULTS: Deletion of the t-PA promoter region - 288 to - 250 resulted in loss of quercetin responsiveness.	Quercetin	81-90	plasminogen activator, tissue type	Homo sapiens	25-29
18419748-14	2008	Inhibition of p38 MAPK abrogated basal and quercetin-induced t-PA expression and promoter activity, as well as quercetin-induced Sp1 binding to Sp1b.	Quercetin	43-52	plasminogen activator, tissue type	Homo sapiens	61-65
18419748-16	2008	CONCLUSIONS: We showed, for the first time, the presence of a functional Sp1-binding element in the t-PA promoter controlling quercetin induction via the p38 MAPK pathway.	Quercetin	126-135	plasminogen activator, tissue type	Homo sapiens	100-104
18322795-12	2008	Taken together, these findings suggest that quercetin results in human glioma cell death through caspase-dependent mechanisms involving down-regulation of ERK, Akt, and survivin.	Quercetin	44-53	AKT serine/threonine kinase 1	Homo sapiens	160-163
18563345-1	2008	The effect of quercetin (Que) on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells was investigated.	Quercetin	14-23	nescient helix-loop-helix 1	Homo sapiens	95-99
18563345-1	2008	The effect of quercetin (Que) on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells was investigated.	Quercetin	25-28	nescient helix-loop-helix 1	Homo sapiens	95-99
18563345-2	2008	Inhibition rate of quercetin on HEN1 was assayed by MTT method, apoptosis by flow cytometry (FCM), and the caspase-3 expression of each group by colorimetry set respectively.	Quercetin	19-28	nescient helix-loop-helix 1	Homo sapiens	32-36
18563345-2	2008	Inhibition rate of quercetin on HEN1 was assayed by MTT method, apoptosis by flow cytometry (FCM), and the caspase-3 expression of each group by colorimetry set respectively.	Quercetin	19-28	caspase 3	Homo sapiens	107-116
18563345-3	2008	Quercetin inhibited HEN1 cells in in a dose-(r=0.709, P&lt;0.01) and time-dependent manner (r=0.703, P&lt;0.01).	Quercetin	0-9	nescient helix-loop-helix 1	Homo sapiens	20-24
18563345-8	2008	It was concluded that the growth inhibition of quercetin was highly related to cell cycle arrest at the G(2)/M phase and induction of caspase-dependent apoptosis in human nasopharyngeal carcinoma HEN1 cells.	Quercetin	47-56	nescient helix-loop-helix 1	Homo sapiens	196-200
18443422-8	2008	Metabolite profiling revealed that the levels of two major glycosides of quercetin and kaempferol were reduced in ugt71c1-1 plants.	Quercetin	73-82	UDP-glucosyl transferase 71C1	Arabidopsis thaliana	114-121
18356015-6	2008	Quercetin increased the populations of propidium-stained cells, shrunken cells, annexin V-positive cells, and the cells with hypodiploidal DNA.	Quercetin	0-9	annexin A5	Rattus norvegicus	80-89
19704584-4	2008	The localised application of selective flavonoids to tt4 mutants such as naringenin, dihydrokaempferol and dihydroquercetin showed that they were taken up at the root tip, mid-root or cotyledons and travelled long distances via cell-to-cell movement to distal tissues and converted to quercetin and kaempferol.	Quercetin	114-123	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	53-56
18359480-2	2008	The present work demonstrates that the flavonoids quercetin and chrysin cooperate with ATO to induce apoptosis in U937 promonocytes and other human leukemia cell lines (THP-1, HL-60).	Quercetin	50-59	GLI family zinc finger 2	Homo sapiens	169-174
18454540-2	2008	Quercetin was shown to be effective in protecting LDL against neutrophil-mediated modification at physiological concentrations (1 microM) and appears to act by inhibiting myeloperoxidase (MPO)-catalyzed oxidation (IC(50) = 1.0 microM).	Quercetin	0-9	myeloperoxidase	Homo sapiens	171-186
18454540-2	2008	Quercetin was shown to be effective in protecting LDL against neutrophil-mediated modification at physiological concentrations (1 microM) and appears to act by inhibiting myeloperoxidase (MPO)-catalyzed oxidation (IC(50) = 1.0 microM).	Quercetin	0-9	myeloperoxidase	Homo sapiens	188-191
18454540-5	2008	Our results suggest that the common dietary flavonoid, quercetin, and some of its major in vivo metabolites are potential inhibitors of MPO at physiological concentrations.	Quercetin	55-64	myeloperoxidase	Homo sapiens	136-139
18377872-0	2008	Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	19-24
18377872-0	2008	Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	69-72
18377872-1	2008	Combined treatment with quercetin and TRAIL induced cytotoxicity and enhanced annexin V staining and poly (ADP-ribose) polymerase (PARP) cleavage in human prostate cancer cell lines DU-145 and PC-3.	Quercetin	24-33	annexin A5	Homo sapiens	78-87
18377872-1	2008	Combined treatment with quercetin and TRAIL induced cytotoxicity and enhanced annexin V staining and poly (ADP-ribose) polymerase (PARP) cleavage in human prostate cancer cell lines DU-145 and PC-3.	Quercetin	24-33	poly(ADP-ribose) polymerase 1	Homo sapiens	101-129
18506933-8	2008	CONCLUSION: The antioxidant action of quercetin relies, in part, on its ability to stimulate nNOS and enhance production of NO that would interact with endogenously produced reactive oxygen to inhibit hyper-proliferation of gastric mucosal cells in rats treated with chronic oral ethanol.	Quercetin	38-47	nitric oxide synthase 1	Rattus norvegicus	93-97
18377872-5	2008	We hypothesized that quercetin-induced activation of MAPK (ERK, p38, JNK) is responsible for downregulation of survivin gene expression.	Quercetin	21-30	mitogen-activated protein kinase 1	Homo sapiens	53-57
18377872-5	2008	We hypothesized that quercetin-induced activation of MAPK (ERK, p38, JNK) is responsible for downregulation of survivin gene expression.	Quercetin	21-30	mitogen-activated protein kinase 1	Homo sapiens	59-62
18377872-5	2008	We hypothesized that quercetin-induced activation of MAPK (ERK, p38, JNK) is responsible for downregulation of survivin gene expression.	Quercetin	21-30	mitogen-activated protein kinase 14	Homo sapiens	64-67
18377872-5	2008	We hypothesized that quercetin-induced activation of MAPK (ERK, p38, JNK) is responsible for downregulation of survivin gene expression.	Quercetin	21-30	mitogen-activated protein kinase 8	Homo sapiens	69-72
18377872-6	2008	To test this hypothesis, we selectively inhibited MAPK during treatment with quercetin.	Quercetin	77-86	mitogen-activated protein kinase 1	Homo sapiens	50-54
18377872-1	2008	Combined treatment with quercetin and TRAIL induced cytotoxicity and enhanced annexin V staining and poly (ADP-ribose) polymerase (PARP) cleavage in human prostate cancer cell lines DU-145 and PC-3.	Quercetin	24-33	poly(ADP-ribose) polymerase 1	Homo sapiens	131-135
18359480-3	2008	Co-treatment with ATO plus quercetin caused mitochondrial transmembrane potential dissipation, stimulated the mitochondrial apoptotic pathway, as indicated by cytochrome c and Omi/Htra2 release, XIAP and Bcl-X(L) down-regulation, and Bax activation, and caused caspase-8/Bid activation.	Quercetin	27-36	cytochrome c, somatic	Homo sapiens	159-171
18377872-7	2008	Our data demonstrated that inhibitor of ERK (PD98059), but not p38 MAPK (SB203580) or JNK (SP600125), significantly maintained the intracellular level of survivin during treatment with quercetin.	Quercetin	185-194	mitogen-activated protein kinase 1	Homo sapiens	40-43
18377872-10	2008	Quercetin-induced activation of the ERK-MSK1 signal transduction pathway may be responsible for deacetylation of histone H3.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	36-39
18359480-3	2008	Co-treatment with ATO plus quercetin caused mitochondrial transmembrane potential dissipation, stimulated the mitochondrial apoptotic pathway, as indicated by cytochrome c and Omi/Htra2 release, XIAP and Bcl-X(L) down-regulation, and Bax activation, and caused caspase-8/Bid activation.	Quercetin	27-36	HtrA serine peptidase 2	Homo sapiens	180-185
18377872-10	2008	Quercetin-induced activation of the ERK-MSK1 signal transduction pathway may be responsible for deacetylation of histone H3.	Quercetin	0-9	ribosomal protein S6 kinase A5	Homo sapiens	40-44
18359480-3	2008	Co-treatment with ATO plus quercetin caused mitochondrial transmembrane potential dissipation, stimulated the mitochondrial apoptotic pathway, as indicated by cytochrome c and Omi/Htra2 release, XIAP and Bcl-X(L) down-regulation, and Bax activation, and caused caspase-8/Bid activation.	Quercetin	27-36	X-linked inhibitor of apoptosis	Homo sapiens	195-199
18377872-11	2008	Taken together, our findings suggest that quercetin enhances TRAIL induced apoptosis by inhibition of survivin expression, through ERK-MSK1-mediated deacetylation of H3.	Quercetin	42-51	TNF superfamily member 10	Homo sapiens	61-66
18377872-11	2008	Taken together, our findings suggest that quercetin enhances TRAIL induced apoptosis by inhibition of survivin expression, through ERK-MSK1-mediated deacetylation of H3.	Quercetin	42-51	mitogen-activated protein kinase 1	Homo sapiens	131-134
18377872-11	2008	Taken together, our findings suggest that quercetin enhances TRAIL induced apoptosis by inhibition of survivin expression, through ERK-MSK1-mediated deacetylation of H3.	Quercetin	42-51	ribosomal protein S6 kinase A5	Homo sapiens	135-139
18359480-3	2008	Co-treatment with ATO plus quercetin caused mitochondrial transmembrane potential dissipation, stimulated the mitochondrial apoptotic pathway, as indicated by cytochrome c and Omi/Htra2 release, XIAP and Bcl-X(L) down-regulation, and Bax activation, and caused caspase-8/Bid activation.	Quercetin	27-36	BCL2 like 1	Homo sapiens	204-212
18359480-3	2008	Co-treatment with ATO plus quercetin caused mitochondrial transmembrane potential dissipation, stimulated the mitochondrial apoptotic pathway, as indicated by cytochrome c and Omi/Htra2 release, XIAP and Bcl-X(L) down-regulation, and Bax activation, and caused caspase-8/Bid activation.	Quercetin	27-36	BCL2 associated X, apoptosis regulator	Homo sapiens	234-237
18359480-3	2008	Co-treatment with ATO plus quercetin caused mitochondrial transmembrane potential dissipation, stimulated the mitochondrial apoptotic pathway, as indicated by cytochrome c and Omi/Htra2 release, XIAP and Bcl-X(L) down-regulation, and Bax activation, and caused caspase-8/Bid activation.	Quercetin	27-36	caspase 8	Homo sapiens	261-270
18359480-3	2008	Co-treatment with ATO plus quercetin caused mitochondrial transmembrane potential dissipation, stimulated the mitochondrial apoptotic pathway, as indicated by cytochrome c and Omi/Htra2 release, XIAP and Bcl-X(L) down-regulation, and Bax activation, and caused caspase-8/Bid activation.	Quercetin	27-36	BH3 interacting domain death agonist	Homo sapiens	271-274
18359480-5	2008	Quercetin and chrysin, alone or with ATO, decreased Akt phosphorylation as well as intracellular GSH content.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	52-55
18460802-5	2008	Quercetin is a flavonoid and a well-known AhR antagonist, while onion contains many flavonoids, including quercetin.	Quercetin	0-9	aryl-hydrocarbon receptor	Mus musculus	42-45
18433793-5	2008	In addition, combinations of resveratrol and quercetin at 25 microM significantly decreased the expression of peroxisome proliferators-activated receptor gamma (PPAR gamma) and CCAAT/enhancer-binding protein (C/EBP)alpha, both of which act as key transcription factors.	Quercetin	45-54	peroxisome proliferator activated receptor gamma	Mus musculus	110-159
18433793-5	2008	In addition, combinations of resveratrol and quercetin at 25 microM significantly decreased the expression of peroxisome proliferators-activated receptor gamma (PPAR gamma) and CCAAT/enhancer-binding protein (C/EBP)alpha, both of which act as key transcription factors.	Quercetin	45-54	peroxisome proliferator activated receptor gamma	Mus musculus	161-171
18433793-5	2008	In addition, combinations of resveratrol and quercetin at 25 microM significantly decreased the expression of peroxisome proliferators-activated receptor gamma (PPAR gamma) and CCAAT/enhancer-binding protein (C/EBP)alpha, both of which act as key transcription factors.	Quercetin	45-54	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	209-220
18433793-8	2008	The combination of resveratrol and quercetin at 100 muM increased release of cytochrome c from mitochondria to cytosol and decreased ERK 1/2 phosphorylation.	Quercetin	35-44	mitogen-activated protein kinase 3	Mus musculus	133-140
18183357-12	2008	These results lead us to conclude that quercetin administration during chelation treatment had some beneficial effects particularly on the protection of inhibited blood ALAD activity and depletion of arsenic level from target organs.	Quercetin	39-48	aminolevulinate, delta-, dehydratase	Mus musculus	169-173
18456490-11	2008	Quercetin treatment produced differential regulation of Cyp1A1 and Cyp1B1 mRNA expression in a time- and dose-dependent manner.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
18234413-9	2008	Protein concentration of the different antioxidant enzymes was generally reduced by kaempferol and quercetin in comparison to CM, although quercetin 25 and 50 microM increased Mn SOD protein concentration.	Quercetin	139-148	superoxide dismutase 2	Homo sapiens	176-182
18456490-0	2008	Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin.	Quercetin	126-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-45
18456490-0	2008	Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin.	Quercetin	126-135	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	51-70
18456490-11	2008	Quercetin treatment produced differential regulation of Cyp1A1 and Cyp1B1 mRNA expression in a time- and dose-dependent manner.	Quercetin	0-9	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	67-73
18456490-12	2008	Treatment with 10 and 50 microM doses of quercetin produced 6- and 11-times greater inductions of Cyp1A1 mRNA over Cyp1B1 mRNA, respectively.	Quercetin	41-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	98-104
18456490-12	2008	Treatment with 10 and 50 microM doses of quercetin produced 6- and 11-times greater inductions of Cyp1A1 mRNA over Cyp1B1 mRNA, respectively.	Quercetin	41-50	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	115-121
18456490-13	2008	Furthermore, quercetin dramatically increased Cyp1A1 protein levels and only slightly increased Cyp1B1 protein levels in MCF10F cells.	Quercetin	13-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	46-52
18456490-13	2008	Furthermore, quercetin dramatically increased Cyp1A1 protein levels and only slightly increased Cyp1B1 protein levels in MCF10F cells.	Quercetin	13-22	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	96-102
17973296-4	2008	Quercetin, a flavonoid with anti-oxidant, anti-inflammatory, and kinase modulating properties, has been found to induce HIF-1alpha accumulation and VEGF secretion in normoxia.	Quercetin	0-9	vascular endothelial growth factor A	Homo sapiens	148-152
18421621-10	2008	Ginkgolide A, B, quercetin, and kaempferol did not affect CYP3A1, but induced CYP1A2 in a dose-dependent manner.	Quercetin	17-26	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	78-84
18421621-13	2008	The results indicate that bilobalide, and to a lesser extent ginkgolide A, B, quercetin, and kaempferol, play a key role in the effects of EGb 761 on CYP induction.	Quercetin	78-87	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	150-153
20731900-0	2008	[Effect of quercetin on the expression and growth of caspase-3 in lung adenocarcinoma cancer cell line A549.].	Quercetin	11-20	caspase 3	Homo sapiens	53-62
20731900-1	2008	BACKGROUND: To study the influence of Quercetin in the expression of caspase-3 in Lung Adenocarcinoma Cancer cell line A549.	Quercetin	38-47	caspase 3	Homo sapiens	69-78
20731900-3	2008	RESULTS: The mRNA and protein expressions of caspase-3 was enhanced by Quercetin in dose- and time-dependent manners.	Quercetin	71-80	caspase 3	Homo sapiens	45-54
20731900-4	2008	CONCLUSIONS: The enhancement effects of Quercetin on caspase-3 in A549 cells may provide promising therapy of tumor.	Quercetin	40-49	caspase 3	Homo sapiens	53-62
18329630-0	2008	Quercetin pretreatment increases the bioavailability of pioglitazone in rats: involvement of CYP3A inhibition.	Quercetin	0-9	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	93-98
18329630-7	2008	These studies indicated potent inhibition of CYP3A activity by quercetin (10 and 20 mg/kg, in vivo; 1 and 10 microM, in vitro).	Quercetin	63-72	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	45-50
18329630-10	2008	Quercetin pretreatment increased AUC(0-infinity) of pioglitazone after oral administration by 75% and AUC(0-infinity) after intravenous administration by 25% suggesting decreased metabolism, which could be due to inhibition of CYP3A by quercetin.	Quercetin	0-9	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	227-232
17973296-8	2008	And we observed that HIF-1alpha accumulated by quercetin is not ubiquitinated and the interaction of HIF-1alpha with pVHL is reduced, compared with HIF-1alpha accumulated by the proteasome inhibitor MG132.	Quercetin	47-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
17973296-9	2008	The use of quercetin"s analogues showed that only quercetin and galangin induce HIF-1/2alpha accumulation and this effect is completely reversed by additional iron ions.	Quercetin	11-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-85
17973296-9	2008	The use of quercetin"s analogues showed that only quercetin and galangin induce HIF-1/2alpha accumulation and this effect is completely reversed by additional iron ions.	Quercetin	50-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-85
17973296-10	2008	This is because quercetin and galangin are able to chelate cellular iron ions that are cofactors of HIF-1/2alpha proline hydroxylase (PHD).	Quercetin	16-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-105
17973296-11	2008	These data suggest that quercetin inhibits the ubiquitination of HIF-1/2alpha in normoxia by hindering PHD through chelating iron ions.	Quercetin	24-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-70
18067462-0	2008	Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin.	Quercetin	71-80	pirin	Homo sapiens	13-18
18313772-7	2008	However, when some PKC inhibitors (rottlerin, BIS-1, Ro-318220, Go-69830, quercetin) were used at higher concentrations (&gt;2 microM), they had a different effect characterized by a dramatic increase in NT binding and an inhibition of NT-induced IP formation.	Quercetin	74-83	protein kinase C delta	Homo sapiens	19-22
18313772-3	2008	Accordingly, PKC inhibitors (staurosporine, Go-6976, Go-6983, Ro-318220, BIS-1, chelerythrine, rottlerin, quercetin) enhanced NT receptor binding and NT-induced inositol phosphate (IP) formation.	Quercetin	106-115	protein kinase C delta	Homo sapiens	13-16
18379051-3	2008	In the previous studies, we demonstrated that quercetin inhibits both glycine and 5-hydroxytryptamine type 3, (5-HT3A) receptor channel activities expressed in Xenopus oocytes.	Quercetin	46-55	5-hydroxytryptamine receptor 3A	Homo sapiens	111-117
18379051-6	2008	In oocytes expressing glycine or 5-HT3A receptors, quercetin- or its glycosides-induced inhibitions on glycine- (IGly) and 5-HT-induced current (I5-HT) were dose-dependent and reversible.	Quercetin	51-60	5-hydroxytryptamine receptor 3A	Homo sapiens	33-39
18067462-2	2008	Here, we show that replication of poliovirus is inhibited by quercetin and that the extent of this inhibition depends on the intracellular content of pirin, a quercetinase.	Quercetin	61-70	pirin	Homo sapiens	150-155
18067462-5	2008	Overexpression of pirin reduced antiviral inhibitory effect of quercetin, while siRNA-induced suppression of pirin level made poliovirus replication more sensitive to the flavonoid.	Quercetin	63-72	pirin	Homo sapiens	18-23
18067462-6	2008	The results suggest that quercetinase activity of pirin determines the resistance of poliovirus infection to quercetin.	Quercetin	25-34	pirin	Homo sapiens	50-55
18404532-0	2008	The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis.	Quercetin	83-92	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	17-22
17936464-8	2008	Quercetin (10 microM) alone even increased H2O2 in LT97 adenoma cells and stimulated VEGF production.	Quercetin	0-9	vascular endothelial growth factor A	Homo sapiens	85-89
18404532-8	2008	Quercetin decreased Rel-A/p65, without modifying upstream signalling.	Quercetin	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	20-25
18404532-8	2008	Quercetin decreased Rel-A/p65, without modifying upstream signalling.	Quercetin	0-9	synaptotagmin 1	Rattus norvegicus	26-29
18356331-10	2008	Among the flavonoid compounds investigated, quercetin, kaempferol, malvidin, peonidin, daidzein, and genistein had inverse associations with serum CRP concentration (P &lt; 0.05).	Quercetin	44-53	C-reactive protein	Homo sapiens	147-150
18341430-9	2008	Quercetin inhibits UV- and H(2)O(2)-induced JNK and c-Jun activation.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	44-47
18385095-11	2008	Hydrogen peroxide-induced activation of caspase-3 was reduced by 50 microM quercetin, from 1.9- to 1.4-fold, compared with untreated control (P &lt; 0.001).	Quercetin	75-84	caspase 3	Homo sapiens	40-49
18385095-15	2008	Quercetin caused a significant dose-dependent reduction of caveolin-1 mRNA 48 hours after treatment with hydrogen peroxide.	Quercetin	0-9	caveolin 1	Homo sapiens	59-69
18297698-2	2008	This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs).	Quercetin	87-96	interleukin 6	Homo sapiens	137-141
18297698-2	2008	This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs).	Quercetin	87-96	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
18297698-2	2008	This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs).	Quercetin	98-100	interleukin 6	Homo sapiens	137-141
18297698-2	2008	This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL-6 and IL-8 from peripheral blood mononuclear cells (PBMCs).	Quercetin	98-100	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
18341430-9	2008	Quercetin inhibits UV- and H(2)O(2)-induced JNK and c-Jun activation.	Quercetin	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-57
18341430-10	2008	Collectively, we conclude that quercetin attenuates both a UV- and H(2)O(2)-induced decrease of collagen type I via the inhibiting of JNK/c-Jun activity.	Quercetin	31-40	mitogen-activated protein kinase 8	Homo sapiens	134-137
17880982-5	2008	We investigated the ability of quercetin and its human metabolites, at physiological concentrations (2 micromol/L and 10 micromol/L), to attenuate the inflammation-induced upregulated expression of VCAM-1, ICAM-1 and of the chemokine, monocyte chemoattractant protein-1 (MCP-1), in human umbilical vein endothelial cells (HUVECs), at the protein and transcript levels.	Quercetin	31-40	vascular cell adhesion molecule 1	Homo sapiens	198-204
18341430-10	2008	Collectively, we conclude that quercetin attenuates both a UV- and H(2)O(2)-induced decrease of collagen type I via the inhibiting of JNK/c-Jun activity.	Quercetin	31-40	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-143
18078968-7	2008	As the results, quercetin and genistein as well as a flavonoid fraction induced apoptosis of tumor cells, which was further accelerated by specific JNK inhibitor, SP600125 or by small interfering RNA specific to JNK1/2.	Quercetin	16-25	mitogen-activated protein kinase 8	Homo sapiens	148-151
18078968-7	2008	As the results, quercetin and genistein as well as a flavonoid fraction induced apoptosis of tumor cells, which was further accelerated by specific JNK inhibitor, SP600125 or by small interfering RNA specific to JNK1/2.	Quercetin	16-25	mitogen-activated protein kinase 8	Homo sapiens	212-218
18321380-4	2008	Based on enzyme studies, the recombinant UGT is a 7-O-glycosyltransferase whose natural substrates include both anthocyanidins and flavonols such as kaempferol and quercetin.	Quercetin	164-173	hydroquinone glucosyltransferase-like	Solanum tuberosum	54-73
18276783-5	2008	HSF-1 activation was associated with an increase in occludin promoter activity, mRNA transcription, and protein expression; which were abolished by the HSF-1 inhibitor quercetin.	Quercetin	168-177	heat shock transcription factor 1	Homo sapiens	0-5
18276783-5	2008	HSF-1 activation was associated with an increase in occludin promoter activity, mRNA transcription, and protein expression; which were abolished by the HSF-1 inhibitor quercetin.	Quercetin	168-177	occludin	Homo sapiens	52-60
18276783-5	2008	HSF-1 activation was associated with an increase in occludin promoter activity, mRNA transcription, and protein expression; which were abolished by the HSF-1 inhibitor quercetin.	Quercetin	168-177	heat shock transcription factor 1	Homo sapiens	152-157
17880982-5	2008	We investigated the ability of quercetin and its human metabolites, at physiological concentrations (2 micromol/L and 10 micromol/L), to attenuate the inflammation-induced upregulated expression of VCAM-1, ICAM-1 and of the chemokine, monocyte chemoattractant protein-1 (MCP-1), in human umbilical vein endothelial cells (HUVECs), at the protein and transcript levels.	Quercetin	31-40	intercellular adhesion molecule 1	Homo sapiens	206-212
17880982-6	2008	Quercetin treatment reduced the inflammation-induced over-expression of VCAM-1 and ICAM-1 (protein and transcript) in HUVECs.	Quercetin	0-9	vascular cell adhesion molecule 1	Homo sapiens	72-78
17880982-6	2008	Quercetin treatment reduced the inflammation-induced over-expression of VCAM-1 and ICAM-1 (protein and transcript) in HUVECs.	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	83-89
17880982-7	2008	Quercetin also inhibited MCP-1 gene expression.	Quercetin	0-9	C-C motif chemokine ligand 2	Homo sapiens	25-30
17804168-8	2008	Co-administration of quercetin with SA abolished the SA-induced HSP70 over-expression and the beneficial effects of SA.	Quercetin	21-30	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	64-69
18323654-0	2008	Stabilization of p53 is involved in quercetin-induced cell cycle arrest and apoptosis in HepG2 cells.	Quercetin	36-45	tumor protein p53	Homo sapiens	17-20
18323654-3	2008	In the present study, we attempted to reactivate p53 in HepG2 retaining wild-type p53 by quercetin, an ubiquitous bioactive plant flavonoid.	Quercetin	89-98	tumor protein p53	Homo sapiens	49-52
18323654-3	2008	In the present study, we attempted to reactivate p53 in HepG2 retaining wild-type p53 by quercetin, an ubiquitous bioactive plant flavonoid.	Quercetin	89-98	tumor protein p53	Homo sapiens	82-85
18323654-5	2008	Molecular data revealed that quercetin induced p53 phosphorylation and total p53 protein, but that it did not up-regulate p53 mRNA at the transcription level.	Quercetin	29-38	tumor protein p53	Homo sapiens	47-50
18323654-5	2008	Molecular data revealed that quercetin induced p53 phosphorylation and total p53 protein, but that it did not up-regulate p53 mRNA at the transcription level.	Quercetin	29-38	tumor protein p53	Homo sapiens	77-80
18323654-5	2008	Molecular data revealed that quercetin induced p53 phosphorylation and total p53 protein, but that it did not up-regulate p53 mRNA at the transcription level.	Quercetin	29-38	tumor protein p53	Homo sapiens	77-80
18323654-6	2008	Consequently, quercetin stimulated p21 expression and suppressed cyclin D1 expression in favor of cell cycle arrest.	Quercetin	14-23	H3 histone pseudogene 16	Homo sapiens	35-38
18323654-6	2008	Consequently, quercetin stimulated p21 expression and suppressed cyclin D1 expression in favor of cell cycle arrest.	Quercetin	14-23	cyclin D1	Homo sapiens	65-74
18323654-7	2008	Quercetin also increased the ratio of Bax/Bcl-2 in favor of apoptosis with such treatment.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	38-41
18323654-7	2008	Quercetin also increased the ratio of Bax/Bcl-2 in favor of apoptosis with such treatment.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	42-47
18323654-8	2008	Interestingly, quercetin inhibited p53 ubiquitination and extended the half-life (t(1/2)) of p53 from 74 to 184 min.	Quercetin	15-24	tumor protein p53	Homo sapiens	35-38
18323654-8	2008	Interestingly, quercetin inhibited p53 ubiquitination and extended the half-life (t(1/2)) of p53 from 74 to 184 min.	Quercetin	15-24	tumor protein p53	Homo sapiens	93-96
18323654-9	2008	Quercetin also inhibited p53 mRNA degradation at the post-transcription stage.	Quercetin	0-9	tumor protein p53	Homo sapiens	25-28
18323654-11	2008	Taken together, our data demonstrate that quercetin stabilized p53 at both the mRNA and protein levels to reactivate p53-dependent cell cycle arrest and apoptosis in HepG2 cells.	Quercetin	42-51	tumor protein p53	Homo sapiens	63-66
18323654-11	2008	Taken together, our data demonstrate that quercetin stabilized p53 at both the mRNA and protein levels to reactivate p53-dependent cell cycle arrest and apoptosis in HepG2 cells.	Quercetin	42-51	tumor protein p53	Homo sapiens	117-120
18061585-3	2008	We demonstrate for the first time that the flavonoids baicalein, luteolin and fisetin, as well as the previously investigated quercetin, induce HIF-1alpha under normal oxygen pressure, whereas kaempferol, taxifolin, and rutin are inactive.	Quercetin	126-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-154
18094037-12	2008	Quercetin (nuclear factor-E2-related factor 2 activator) induced UGT1A6 mRNA (6.7-fold in colon and 2.2-fold in proximal jejunum).	Quercetin	0-9	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	65-71
19255595-7	2008	Continual dietary exposure to chrysin and quercetin, found in fruits and vegetables, induces UGT1A1 and may reduce exposure to hydroxylated PCBs through increased glucuronidation.	Quercetin	42-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	93-99
18164738-4	2008	UDP-glucosyltransferase (UGT) in the midgut could transfer glucose to each of the hydroxyl groups of quercetin, with a preference for formation of 5-O-glucoside, while quercetin 5,4"-di-O-glucoside was predominantly produced if the enzyme extracts of either the fat body or silk glands were incubated with quercetin 5-O-glucoside and UDP-glucose.	Quercetin	101-110	UDP-glucosyltransferase	Bombyx mori	0-23
18164738-4	2008	UDP-glucosyltransferase (UGT) in the midgut could transfer glucose to each of the hydroxyl groups of quercetin, with a preference for formation of 5-O-glucoside, while quercetin 5,4"-di-O-glucoside was predominantly produced if the enzyme extracts of either the fat body or silk glands were incubated with quercetin 5-O-glucoside and UDP-glucose.	Quercetin	101-110	UDP-glucosyltransferase	Bombyx mori	25-28
18245498-0	2008	Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine.	Quercetin	91-100	zinc fingers and homeoboxes 2	Homo sapiens	0-3
18245498-11	2008	Docking data suggested that quercetin, but not resveratrol, formed a hydrogen bond with the backbone amide group of Ser(212), which is the key interaction for stabilizing the inactive conformation of the activation loop of MEK1.	Quercetin	28-37	mitogen-activated protein kinase kinase 1	Homo sapiens	223-227
18192686-6	2008	Levels of COMT messenger RNA (mRNA) were determined by reverse transcription/competitive polymerase chain reaction and COMT activity was determined by high-performance liquid chromatography analysis of the methylation products of both the model substrate quercetin and the physiological relevant substrate 4-HO-E2.	Quercetin	255-264	catechol-O-methyltransferase	Homo sapiens	119-123
18245498-0	2008	Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine.	Quercetin	91-100	mitogen-activated protein kinase kinase 7	Homo sapiens	8-11
18245498-4	2008	The activation of activator protein-1 and nuclear factor-kappaB induced by TPA was dose dependently inhibited by RWE or quercetin treatment.	Quercetin	120-129	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-37
18245498-5	2008	Western blot and kinase assay data revealed that RWE or quercetin inhibited mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) 1 and Raf1 kinase activities and subsequently attenuated TPA-induced phosphorylation of ERK/p90 ribosomal S6 kinase.	Quercetin	56-65	mitogen-activated protein kinase kinase 1	Homo sapiens	109-167
18245498-5	2008	Western blot and kinase assay data revealed that RWE or quercetin inhibited mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) 1 and Raf1 kinase activities and subsequently attenuated TPA-induced phosphorylation of ERK/p90 ribosomal S6 kinase.	Quercetin	56-65	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	172-176
18245498-6	2008	Although either RWE or quercetin suppressed Raf1 kinase activity, they were more effective in inhibiting MEK1 activity.	Quercetin	23-32	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	44-48
18245498-6	2008	Although either RWE or quercetin suppressed Raf1 kinase activity, they were more effective in inhibiting MEK1 activity.	Quercetin	23-32	mitogen-activated protein kinase kinase 1	Homo sapiens	105-109
18245498-7	2008	Importantly, quercetin exerted stronger inhibitory effects than PD098059, a well-known pharmacologic inhibitor of MEK.	Quercetin	13-22	mitogen-activated protein kinase kinase 7	Homo sapiens	114-117
18245498-9	2008	Pull-down assays revealed that RWE or quercetin (but not resveratrol) bound with either MEK1 or Raf1.	Quercetin	38-47	mitogen-activated protein kinase kinase 1	Homo sapiens	88-92
18245498-9	2008	Pull-down assays revealed that RWE or quercetin (but not resveratrol) bound with either MEK1 or Raf1.	Quercetin	38-47	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	96-100
18245498-10	2008	RWE or quercetin also dose dependently suppressed JB6 P+ cell transformation induced by epidermal growth factor or H-Ras, both of which are involved in the activation of MEK/ERK signaling.	Quercetin	7-16	HRas proto-oncogene, GTPase	Homo sapiens	115-120
18024103-6	2008	Quercetin treatment also led to a translocation of the C. elegans FoxO transcription factor DAF-16 into the nucleus, a state often correlated with stress response and longevity.	Quercetin	0-9	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	92-98
18245498-10	2008	RWE or quercetin also dose dependently suppressed JB6 P+ cell transformation induced by epidermal growth factor or H-Ras, both of which are involved in the activation of MEK/ERK signaling.	Quercetin	7-16	mitogen-activated protein kinase kinase 7	Homo sapiens	170-173
18092747-11	2008	The increase in beta-glucuronidase activity with carcinogenesis induction became insignificant following the frequent doses of quercetin.	Quercetin	127-136	glucuronidase, beta	Rattus norvegicus	16-34
17531458-6	2008	On the other hand, [3H]FA uptake was significantly increased by chronic exposure to xanthohumol, quercetin or isoxanthohumol (0.1-10 microM), and this increase does not seem to result from changes in the level of RFC1 or FRalpha gene expression.	Quercetin	97-106	replication factor C subunit 1	Homo sapiens	213-217
17531458-6	2008	On the other hand, [3H]FA uptake was significantly increased by chronic exposure to xanthohumol, quercetin or isoxanthohumol (0.1-10 microM), and this increase does not seem to result from changes in the level of RFC1 or FRalpha gene expression.	Quercetin	97-106	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	221-228
17988664-0	2008	Quercetin accelerates TNF-alpha-induced apoptosis of MC3T3-E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways.	Quercetin	0-9	tumor necrosis factor	Mus musculus	22-31
17988664-0	2008	Quercetin accelerates TNF-alpha-induced apoptosis of MC3T3-E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways.	Quercetin	0-9	mitogen-activated protein kinase 8	Mus musculus	111-114
17988664-3	2008	Therefore, this study was carried out to examine the cellular mechanisms for how quercetin accelerates TNF-alpha-mediated apoptosis, and to determine whether the accelerating effect of quercetin is a general effect in osteoblastic cells.	Quercetin	81-90	tumor necrosis factor	Mus musculus	103-112
17988664-4	2008	Quercetin promoted the TNF-alpha-induced apoptosis of MC3T3-E1 cells through both the mitochondrial-mediated and caspase-dependent mechanisms.	Quercetin	0-9	tumor necrosis factor	Mus musculus	23-32
17988664-5	2008	Quercetin also augmented the TNF-alpha-mediated apoptosis by activating c-Jun N-terminal kinase (JNK) with the attendant activation of activator protein-1, where the nuclear translocation of c-Jun protein appeared to be a critical event responsible for the accelerating action of quercetin.	Quercetin	0-9	tumor necrosis factor	Mus musculus	29-38
17988664-5	2008	Quercetin also augmented the TNF-alpha-mediated apoptosis by activating c-Jun N-terminal kinase (JNK) with the attendant activation of activator protein-1, where the nuclear translocation of c-Jun protein appeared to be a critical event responsible for the accelerating action of quercetin.	Quercetin	0-9	mitogen-activated protein kinase 8	Mus musculus	72-95
17988664-5	2008	Quercetin also augmented the TNF-alpha-mediated apoptosis by activating c-Jun N-terminal kinase (JNK) with the attendant activation of activator protein-1, where the nuclear translocation of c-Jun protein appeared to be a critical event responsible for the accelerating action of quercetin.	Quercetin	0-9	mitogen-activated protein kinase 8	Mus musculus	97-100
17988664-5	2008	Quercetin also augmented the TNF-alpha-mediated apoptosis by activating c-Jun N-terminal kinase (JNK) with the attendant activation of activator protein-1, where the nuclear translocation of c-Jun protein appeared to be a critical event responsible for the accelerating action of quercetin.	Quercetin	0-9	jun proto-oncogene	Mus musculus	135-154
17988664-5	2008	Quercetin also augmented the TNF-alpha-mediated apoptosis by activating c-Jun N-terminal kinase (JNK) with the attendant activation of activator protein-1, where the nuclear translocation of c-Jun protein appeared to be a critical event responsible for the accelerating action of quercetin.	Quercetin	0-9	jun proto-oncogene	Mus musculus	72-77
17988664-5	2008	Quercetin also augmented the TNF-alpha-mediated apoptosis by activating c-Jun N-terminal kinase (JNK) with the attendant activation of activator protein-1, where the nuclear translocation of c-Jun protein appeared to be a critical event responsible for the accelerating action of quercetin.	Quercetin	280-289	tumor necrosis factor	Mus musculus	29-38
17988664-5	2008	Quercetin also augmented the TNF-alpha-mediated apoptosis by activating c-Jun N-terminal kinase (JNK) with the attendant activation of activator protein-1, where the nuclear translocation of c-Jun protein appeared to be a critical event responsible for the accelerating action of quercetin.	Quercetin	280-289	jun proto-oncogene	Mus musculus	135-154
17988664-6	2008	However, TNF-alpha-mediated apoptosis and its acceleration by quercetin were not observed in primary osteoblasts.	Quercetin	62-71	tumor necrosis factor	Mus musculus	9-18
17988664-7	2008	These results strongly suggest that quercetin accelerates TNF-alpha-mediated apoptosis of osteoblasts through caspase-dependent and JNK-mediated pathways, and that the cellular responses of osteoblasts to TNF-alpha and/or quercetin might differ according to their origins.	Quercetin	36-45	tumor necrosis factor	Mus musculus	58-67
17988664-7	2008	These results strongly suggest that quercetin accelerates TNF-alpha-mediated apoptosis of osteoblasts through caspase-dependent and JNK-mediated pathways, and that the cellular responses of osteoblasts to TNF-alpha and/or quercetin might differ according to their origins.	Quercetin	36-45	mitogen-activated protein kinase 8	Mus musculus	132-135
17929310-5	2008	For glial cells, we observed that lipopolysaccharide (LPS)-induced mRNA levels of two proinflammatory genes, interleukin 1-alpha and tumor necrosis factor-alpha, are strongly decreased by treatments with resveratrol or quercetin.	Quercetin	219-228	interleukin 1 alpha	Homo sapiens	109-160
18497090-5	2008	CYP1A1 and COMT enzyme activity were determined using ethoxyresorufin and quercetin as substrates.	Quercetin	74-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
18231933-2	2008	First, the antioxidant dietary compound, quercetin, was shown to inhibit GPVI-dependent platelet activation and signaling responses to collagen.	Quercetin	41-50	glycoprotein VI platelet	Homo sapiens	73-77
19112469-4	2008	Reduction of Hsp72 gene expression in neuroblastoma cells by antisense oligonucleotides made them more sensitive to pro-apoptotic action of quercetin.	Quercetin	140-149	heat shock protein family A (Hsp70) member 1A	Homo sapiens	13-18
19112469-6	2008	Nuclear localization of mainly cytoplasmic Hsp27 was observed in neuroblastoma cells after treatment with high quercetin concentrations, while in neurons, the protein was present in nuclei both in control and quercetin treated cells.	Quercetin	111-120	heat shock protein family B (small) member 1	Homo sapiens	43-48
19112469-6	2008	Nuclear localization of mainly cytoplasmic Hsp27 was observed in neuroblastoma cells after treatment with high quercetin concentrations, while in neurons, the protein was present in nuclei both in control and quercetin treated cells.	Quercetin	209-218	heat shock protein family B (small) member 1	Homo sapiens	43-48
18497090-5	2008	CYP1A1 and COMT enzyme activity were determined using ethoxyresorufin and quercetin as substrates.	Quercetin	74-83	catechol-O-methyltransferase	Homo sapiens	11-15
18791269-0	2008	Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.	Quercetin	72-81	tyrosinase	Homo sapiens	0-10
18791269-0	2008	Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.	Quercetin	72-81	ATM serine/threonine kinase	Homo sapiens	35-38
17938562-6	2008	When we inhibited HSP70 by adding quercetin, death was increased in both young and old keratinocytes, but more so in old keratinocytes.	Quercetin	34-43	heat shock protein family A (Hsp70) member 4	Homo sapiens	18-23
18791269-0	2008	Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.	Quercetin	72-81	tumor protein p53	Homo sapiens	49-52
18791269-4	2008	Here, we demonstrate that tyrosinase which is commonly overexpressed in melanoma activates the bioflavonoid quercetin (Qct) and promotes an ataxia telangiectasia mutated (ATM)-dependent DNA damage response.	Quercetin	108-117	tyrosinase	Homo sapiens	26-36
18720166-1	2008	Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	Quercetin	0-9	tumor necrosis factor	Homo sapiens	119-146
19326773-13	2008	All bioflavonoids, i.e., quercetin, diosmin, methyl hesperidin, gossypin and chrysin, decreased the transport of nitrendipine, a P-gp substrate in the rat intestine.	Quercetin	25-34	phosphoglycolate phosphatase	Rattus norvegicus	129-133
18720166-1	2008	Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	Quercetin	0-9	tumor necrosis factor	Homo sapiens	148-157
18720166-1	2008	Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	Quercetin	0-9	interleukin 6	Homo sapiens	164-177
18720166-1	2008	Quercetin (QUER) and luteolin (LUTE) are dietary flavonoids capable of regulating the production of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	Quercetin	0-9	interleukin 6	Homo sapiens	179-183
18979154-0	2008	The flavonoid quercetin induces apoptosis and inhibits migration through a MAPK-dependent mechanism in osteoblasts.	Quercetin	14-23	mitogen-activated protein kinase 1	Homo sapiens	75-79
18979154-5	2008	Western blot analysis showed that quercetin induced activation of ERK and p38, but not JNK.	Quercetin	34-43	mitogen-activated protein kinase 1	Homo sapiens	66-69
18979154-5	2008	Western blot analysis showed that quercetin induced activation of ERK and p38, but not JNK.	Quercetin	34-43	mitogen-activated protein kinase 14	Homo sapiens	74-77
18979154-6	2008	Quercetin-induced cell death was prevented by the ERK inhibitor PD98059, but not by inhibitors of p38 and JNK.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	50-53
18979154-7	2008	Quercetin increased Bax expression and caused depolarization of mitochondrial membrane potential, which were inhibited by PD98059.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	20-23
18979154-8	2008	Quercetin induced caspase-3 activation, and the quercetininduced cell death was prevented by caspase inhibitors.	Quercetin	0-9	caspase 3	Homo sapiens	18-27
18979154-9	2008	Quercetin inhibited cell migration, and its effect was prevented by inhibitors of ERK and p38.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	82-85
18979154-9	2008	Quercetin inhibited cell migration, and its effect was prevented by inhibitors of ERK and p38.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	90-93
18979154-10	2008	Taken together, these findings suggest that quercetin induces apoptosis through a mitochondria-dependent mechanism involving ERK activation and inhibits migration through activation of ERK and p38 pathways.	Quercetin	44-53	mitogen-activated protein kinase 1	Homo sapiens	125-128
18979154-10	2008	Taken together, these findings suggest that quercetin induces apoptosis through a mitochondria-dependent mechanism involving ERK activation and inhibits migration through activation of ERK and p38 pathways.	Quercetin	44-53	mitogen-activated protein kinase 1	Homo sapiens	185-188
18979154-10	2008	Taken together, these findings suggest that quercetin induces apoptosis through a mitochondria-dependent mechanism involving ERK activation and inhibits migration through activation of ERK and p38 pathways.	Quercetin	44-53	mitogen-activated protein kinase 14	Homo sapiens	193-196
19005980-9	2008	The rank order of VEGF protein secretion inhibitory potency was genistein &gt; kaempferol &gt; apigenin &gt; quercetin &gt; tocopherol &gt; luteolin &gt; cisplatin &gt; rutin &gt; naringin &gt; taxifolin.	Quercetin	109-118	vascular endothelial growth factor A	Homo sapiens	18-22
17916758-6	2008	In HL-60 cells, but not endothelial or smooth muscle cells, DiOHF and quercetin (10 and 30 microM) significantly reduced the protein expression of p47phox, whereas p67phox was not altered.	Quercetin	70-79	neutrophil cytosolic factor 1	Homo sapiens	147-154
19005980-10	2008	Genistein, quercetin, and luteolin have shown strong inhibition to cell proliferation and VEGF expression of human ovarian cancer cells, and they show promising in the prevention of ovarian cancers.	Quercetin	11-20	vascular endothelial growth factor A	Homo sapiens	90-94
17763450-8	2008	The expression of PG and Col II mRNA was higher, with more than 20 W of heat stimulation and peaked with 40 W. When quercetin was used to inhibit the induction of HSP70 expression, PG mRNA expression did not increase.	Quercetin	116-125	LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like	Oryctolagus cuniculus	163-168
17465695-6	2008	Quercetin and resveratrol decreased the release of nitric oxide by these cells in a dose-dependent manner which corresponded to a decrease in iNOS expression in the case of quercetin.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	142-146
17465695-6	2008	Quercetin and resveratrol decreased the release of nitric oxide by these cells in a dose-dependent manner which corresponded to a decrease in iNOS expression in the case of quercetin.	Quercetin	173-182	nitric oxide synthase 2, inducible	Mus musculus	142-146
18004880-0	2007	Albumin-bound quercetin repairs vitamin E oxidized by apolipoprotein radicals in native HDL3 and LDL.	Quercetin	14-23	HDL3	Homo sapiens	88-92
18095365-4	2008	In addition, quercetin enhanced expression of tumor suppressor genes, including Pten, Tp53, and Msh2, and of cell cycle inhibitors, including Mutyh.	Quercetin	13-22	phosphatase and tensin homolog	Rattus norvegicus	80-84
18095365-4	2008	In addition, quercetin enhanced expression of tumor suppressor genes, including Pten, Tp53, and Msh2, and of cell cycle inhibitors, including Mutyh.	Quercetin	13-22	tumor protein p53	Rattus norvegicus	86-90
18095365-4	2008	In addition, quercetin enhanced expression of tumor suppressor genes, including Pten, Tp53, and Msh2, and of cell cycle inhibitors, including Mutyh.	Quercetin	13-22	mutS homolog 2	Rattus norvegicus	96-100
18095365-4	2008	In addition, quercetin enhanced expression of tumor suppressor genes, including Pten, Tp53, and Msh2, and of cell cycle inhibitors, including Mutyh.	Quercetin	13-22	mutY DNA glycosylase	Rattus norvegicus	142-147
18095365-5	2008	Furthermore, dietary quercetin enhanced genes involved in phase I and II metabolism, including Fmo5, Ephx1, Ephx2, and Gpx2.	Quercetin	21-30	flavin containing dimethylaniline monoxygenase 5	Rattus norvegicus	95-99
18095365-5	2008	Furthermore, dietary quercetin enhanced genes involved in phase I and II metabolism, including Fmo5, Ephx1, Ephx2, and Gpx2.	Quercetin	21-30	epoxide hydrolase 1	Rattus norvegicus	101-106
18095365-5	2008	Furthermore, dietary quercetin enhanced genes involved in phase I and II metabolism, including Fmo5, Ephx1, Ephx2, and Gpx2.	Quercetin	21-30	epoxide hydrolase 2	Rattus norvegicus	108-113
18095365-5	2008	Furthermore, dietary quercetin enhanced genes involved in phase I and II metabolism, including Fmo5, Ephx1, Ephx2, and Gpx2.	Quercetin	21-30	glutathione peroxidase 2	Rattus norvegicus	119-123
18095365-6	2008	Quercetin increased PPARalpha target genes, and concomitantly enhanced expression of genes involved in mitochondrial fatty acid (FA) degradation.	Quercetin	0-9	peroxisome proliferator activated receptor alpha	Rattus norvegicus	20-29
18004880-5	2007	In the major fraction of HDL3 particles lacking alphaTocOH, TyrO* and *Trp are repaired by free and HSA-bound quercetin.	Quercetin	110-119	HDL3	Homo sapiens	25-29
17876860-5	2007	The grapefruit constituent, quercetin, completely inhibited SULT1A1, while quercetin and naringin both partially inhibited SULT1A3.	Quercetin	28-37	sulfotransferase family 1A member 1	Homo sapiens	60-67
18254248-8	2007	These results indicate that quercetin and rutin may be useful in the treatment of IAR and LAR in asthma via inhibition of histamine release, PLA2, and EPO, and reduced recruitment of neutrophils and eosinophils into the lung.	Quercetin	28-37	erythropoietin	Cavia porcellus	151-154
17876860-5	2007	The grapefruit constituent, quercetin, completely inhibited SULT1A1, while quercetin and naringin both partially inhibited SULT1A3.	Quercetin	75-84	sulfotransferase family 1A member 3	Homo sapiens	123-130
17475462-8	2007	Thus, ASP and quercetin reduce the oxidative modification of apo B-100 and stabilize LDL conformation in a dose-dependent manner, acting in an additive or synergistic fashion with VC and VE.	Quercetin	14-23	apolipoprotein B	Homo sapiens	61-70
17706336-0	2007	GSTM1 and GSTT1 polymorphism influences protection against induced oxidative DNA damage by quercetin and ascorbic acid in human lymphocytes in vitro.	Quercetin	91-100	glutathione S-transferase mu 1	Homo sapiens	0-5
17706336-0	2007	GSTM1 and GSTT1 polymorphism influences protection against induced oxidative DNA damage by quercetin and ascorbic acid in human lymphocytes in vitro.	Quercetin	91-100	glutathione S-transferase theta 1	Homo sapiens	10-15
17706336-2	2007	This study aims to establish the impact of genetic polymorphisms in GSTM1 and GSTT1, which encode for enzymatic antioxidative defence, on H(2)O(2)-induced oxidative DNA damage and on the effectiveness of quercetin and ascorbic acid in preventing this induced damage in human lymphocytes.	Quercetin	204-213	glutathione S-transferase mu 1	Homo sapiens	68-73
17706336-2	2007	This study aims to establish the impact of genetic polymorphisms in GSTM1 and GSTT1, which encode for enzymatic antioxidative defence, on H(2)O(2)-induced oxidative DNA damage and on the effectiveness of quercetin and ascorbic acid in preventing this induced damage in human lymphocytes.	Quercetin	204-213	glutathione S-transferase theta 1	Homo sapiens	78-83
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Quercetin	64-73	glutathione S-transferase theta 1	Homo sapiens	102-107
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Quercetin	64-73	glutathione S-transferase theta 1	Homo sapiens	127-132
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Quercetin	64-73	glutathione S-transferase theta 1	Homo sapiens	127-132
17706336-8	2007	The protection against H(2)O(2)-induced oxidative DNA damage by quercetin was significantly higher in GSTT1 wild types than in GSTT1 variants (57% and 9% decrease, respectively; p=0.01); furthermore, GSTT1 wild types were protected against induced oxidative DNA damage by ascorbic acid pre-incubation while GSTT1 variants showed an increase of damage (16% decrease vs. 91% increase; p=0.01).	Quercetin	64-73	glutathione S-transferase theta 1	Homo sapiens	127-132
17475462-0	2007	Effect of almond skin polyphenolics and quercetin on human LDL and apolipoprotein B-100 oxidation and conformation.	Quercetin	40-49	apolipoprotein B	Homo sapiens	67-87
18330265-0	2007	[Effect of quercetin on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells].	Quercetin	11-20	nescient helix-loop-helix 1	Homo sapiens	86-90
18330265-1	2007	OBJECTIVE: To investigate the effect of quercetin (Que) on HEN1 cells, a kind of human nasopharyngeal carcinoma cells.	Quercetin	40-49	nescient helix-loop-helix 1	Homo sapiens	59-63
18330265-2	2007	METHOD: Inhibition rate of quercetin on HEN1 was assayed by MTT method, cell apoptosis by flow cytometry (FCM), Caspase-3 expression of each group were determined by colorimetry set.	Quercetin	27-36	nescient helix-loop-helix 1	Homo sapiens	40-44
18330265-3	2007	RESULT: The inhibition of quercetin on HEN1 cells was shown in the dose-dependent (r = 0.709, P &lt; 0.05) and time-dependent manner (r = 0.703, P &lt; 0.01).	Quercetin	26-35	nescient helix-loop-helix 1	Homo sapiens	39-43
18330265-7	2007	While the activity of caspase-3 were also significantly upregulated in five groups after quercetin compared to control (P &lt; 0.05).	Quercetin	89-98	caspase 3	Homo sapiens	22-31
18330265-8	2007	CONCLUSION: Quercetin can activate the expression of Caspase-3 and induce the apoptosis of HEN1 cells through mitochondrion-depended pathway.	Quercetin	12-21	caspase 3	Homo sapiens	53-62
18330265-8	2007	CONCLUSION: Quercetin can activate the expression of Caspase-3 and induce the apoptosis of HEN1 cells through mitochondrion-depended pathway.	Quercetin	12-21	nescient helix-loop-helix 1	Homo sapiens	91-95
17920288-2	2007	Five flavonoids (morin, silybin, naringin, naringenin and quercetin) were selected and their interaction characteristics with hOAT1 and hOAT3 were examined in MDCK cells overexpressing hOAT1 or hOAT3.	Quercetin	58-67	solute carrier family 22 member 6	Homo sapiens	126-131
17920288-2	2007	Five flavonoids (morin, silybin, naringin, naringenin and quercetin) were selected and their interaction characteristics with hOAT1 and hOAT3 were examined in MDCK cells overexpressing hOAT1 or hOAT3.	Quercetin	58-67	solute carrier family 22 member 8	Homo sapiens	136-141
17670841-8	2007	In particular, a relatively specific inhibitor of CYP2C8 (quercetin) markedly inhibited the formation of this metabolite.	Quercetin	58-67	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	50-56
17998018-5	2007	A decrease of nuclear factor-kappaB and the antiapoptotic protein Mcl-1 and an increase of the proapoptotic protein Bad were observed in time-dependent fashion in the quercetin-treated cells compared with the vehicle-treated cells by Western blot analysis.	Quercetin	167-176	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	66-71
17998018-7	2007	Interestingly, exposure of AML-I to quercetin for 6 days increased the amount of cytoplasmic lipid droplets as well as the expression of fatty acid synthase and peroxisome proliferator-activated receptor gamma proteins.	Quercetin	36-45	fatty acid synthase	Homo sapiens	137-156
17998018-7	2007	Interestingly, exposure of AML-I to quercetin for 6 days increased the amount of cytoplasmic lipid droplets as well as the expression of fatty acid synthase and peroxisome proliferator-activated receptor gamma proteins.	Quercetin	36-45	peroxisome proliferator activated receptor gamma	Homo sapiens	161-209
17681842-0	2007	Examination of KNK437- and quercetin-mediated inhibition of heat shock-induced heat shock protein gene expression in Xenopus laevis cultured cells.	Quercetin	27-36	heat shock 70kDa protein L homeolog	Xenopus laevis	79-97
17644434-5	2007	Since serum albumin, the principal carrier protein for quercetin gets depleted in visceral leishmaniasis, the situation may compromise the efficacy of quercetin in this disease.	Quercetin	55-64	albumin	Homo sapiens	6-19
17644434-5	2007	Since serum albumin, the principal carrier protein for quercetin gets depleted in visceral leishmaniasis, the situation may compromise the efficacy of quercetin in this disease.	Quercetin	151-160	albumin	Homo sapiens	6-19
17681842-2	2007	In previous studies, both quercetin and KNK437 inhibited heat shock factor activity resulting in a repression of hsp mRNA and protein accumulation in human cultured cells.	Quercetin	26-35	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	113-116
17681842-3	2007	In this first study of the effect of these hsp gene expression inhibitors in a non-mammalian cell line, we report that both quercetin and KNK437 reduced the heat shock-induced accumulation of hsp30, hsp47 and hsp70 mRNA in X. laevis cultured cells.	Quercetin	124-133	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	43-46
17681842-3	2007	In this first study of the effect of these hsp gene expression inhibitors in a non-mammalian cell line, we report that both quercetin and KNK437 reduced the heat shock-induced accumulation of hsp30, hsp47 and hsp70 mRNA in X. laevis cultured cells.	Quercetin	124-133	heat shock protein 30E L homeolog	Xenopus laevis	192-197
17681842-3	2007	In this first study of the effect of these hsp gene expression inhibitors in a non-mammalian cell line, we report that both quercetin and KNK437 reduced the heat shock-induced accumulation of hsp30, hsp47 and hsp70 mRNA in X. laevis cultured cells.	Quercetin	124-133	serpin family H member 1	Homo sapiens	199-204
17681842-3	2007	In this first study of the effect of these hsp gene expression inhibitors in a non-mammalian cell line, we report that both quercetin and KNK437 reduced the heat shock-induced accumulation of hsp30, hsp47 and hsp70 mRNA in X. laevis cultured cells.	Quercetin	124-133	heat shock protein family A (Hsp70) member 4	Homo sapiens	209-214
17681842-5	2007	Western blot and immunocytochemical analyses revealed that quercetin partially inhibited HSP30 protein accumulation.	Quercetin	59-68	heat shock protein 30E L homeolog	Xenopus laevis	89-94
17717114-7	2007	Muscle NF-kappaB did not increase postexercise and did not differ between Q and P. Muscle COX-2 mRNA increased significantly postexercise but did not differ between Q and P. In summary, 1 g/day quercetin supplementation by trained cyclists over a 24-day period diminished postexercise expression of leukocyte IL-8 and IL-10 mRNA, indicating that elevated plasma quercetin levels exerted some effects within the blood compartment.	Quercetin	194-203	prostaglandin-endoperoxide synthase 2	Homo sapiens	90-95
17680992-6	2007	Quercetin was found to inhibit HSP expression depleting heat shock factor 1 (HSF1) cellular stores.	Quercetin	0-9	heat shock transcription factor 1	Homo sapiens	56-75
17680992-6	2007	Quercetin was found to inhibit HSP expression depleting heat shock factor 1 (HSF1) cellular stores.	Quercetin	0-9	heat shock transcription factor 1	Homo sapiens	77-81
17548900-0	2007	Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells.	Quercetin	119-128	TNF receptor superfamily member 10b	Homo sapiens	13-29
18090225-5	2007	Quercetin, apigenin, and luteolin completely protected against IL-1beta- and IFN-gamma-mediated cytotoxicity in RIN cells.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	63-71
18090225-5	2007	Quercetin, apigenin, and luteolin completely protected against IL-1beta- and IFN-gamma-mediated cytotoxicity in RIN cells.	Quercetin	0-9	interferon gamma	Rattus norvegicus	77-86
18090225-6	2007	Incubation with quercetin, apigenin, and luteolin resulted in a significant reduction in IL-1beta- and IFN-gamma-induced nitric oxide production, a finding that correlated well with reduced levels of the inducible form of NO synthase messenger RNA and protein.	Quercetin	16-25	interleukin 1 beta	Rattus norvegicus	89-97
18090225-6	2007	Incubation with quercetin, apigenin, and luteolin resulted in a significant reduction in IL-1beta- and IFN-gamma-induced nitric oxide production, a finding that correlated well with reduced levels of the inducible form of NO synthase messenger RNA and protein.	Quercetin	16-25	interferon gamma	Rattus norvegicus	103-112
18090225-7	2007	The molecular mechanism by which quercetin, apigenin, and luteolin inhibited inducible NO synthase gene expression appeared to involve the inhibition of nuclear factor kappaB (NF-kappaB) activation.	Quercetin	33-42	nitric oxide synthase 2	Rattus norvegicus	77-98
18090225-9	2007	Quercetin, apigenin, and luteolin also prevented IL-1beta- and IFN-gamma-mediated inhibition of insulin secretion.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	49-57
18090225-9	2007	Quercetin, apigenin, and luteolin also prevented IL-1beta- and IFN-gamma-mediated inhibition of insulin secretion.	Quercetin	0-9	interferon gamma	Rattus norvegicus	63-72
18090225-10	2007	CONCLUSION: Quercetin, apigenin, and luteolin inhibited cytotoxicity in RIN cells and attenuated the decrease of glucose-stimulated insulin secretion in islets by IL-1beta and IFN-gamma.	Quercetin	12-21	interleukin 1 beta	Rattus norvegicus	163-171
18090225-10	2007	CONCLUSION: Quercetin, apigenin, and luteolin inhibited cytotoxicity in RIN cells and attenuated the decrease of glucose-stimulated insulin secretion in islets by IL-1beta and IFN-gamma.	Quercetin	12-21	interferon gamma	Rattus norvegicus	176-185
18274286-5	2007	Among them, only quercetin showed a substantial inhibition (76.2%) against AChE, while genistein (65.7%), luteolin-7-O-rutinoside (54.9%), and silibinin (51.4%) exerted a moderate inhibition on BChE.	Quercetin	17-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79
18274286-5	2007	Among them, only quercetin showed a substantial inhibition (76.2%) against AChE, while genistein (65.7%), luteolin-7-O-rutinoside (54.9%), and silibinin (51.4%) exerted a moderate inhibition on BChE.	Quercetin	17-26	butyrylcholinesterase	Homo sapiens	194-198
17914217-5	2007	Treatment with quercetin resulted in a significant decrease in Na+ and Ca2+ and aldose reductase levels and an increase in K+ and protein levels in galactosemic cataractous lenses.	Quercetin	15-24	aldo-keto reductase family 1 member B1	Rattus norvegicus	80-96
17548900-0	2007	Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells.	Quercetin	119-128	TNF superfamily member 10	Homo sapiens	89-94
17548900-2	2007	In this report, we demonstrate that quercetin significantly enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cytotoxicity in non-small cell lung cancer (NSCLC) cells.	Quercetin	36-45	TNF superfamily member 10	Homo sapiens	69-124
17548900-2	2007	In this report, we demonstrate that quercetin significantly enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cytotoxicity in non-small cell lung cancer (NSCLC) cells.	Quercetin	36-45	TNF superfamily member 10	Homo sapiens	126-131
17548900-3	2007	Quercetin increased expression of death receptor (DR) 5, whereas it had no effect on that of other components of the death-inducing signaling complex.	Quercetin	0-9	TNF receptor superfamily member 10b	Homo sapiens	34-55
17548900-6	2007	In contrast, the blockage of the serine/threonine kinase Akt activity by quercetin is important for inhibition of survivin expression but not induction of DR5.	Quercetin	73-82	AKT serine/threonine kinase 1	Homo sapiens	57-60
17548900-7	2007	These results suggest the pathways for regulation of DR5 and survivin expression by quercetin are distinct.	Quercetin	84-93	TNF receptor superfamily member 10b	Homo sapiens	53-56
17548900-8	2007	Importantly, suppression of survivin-sensitized TRAIL-induced cell death and blockage of DR5 expression suppressed the synergistic cytotoxicity induced by quercetin and TRAIL co-treatment.	Quercetin	155-164	TNF receptor superfamily member 10b	Homo sapiens	89-92
17548900-9	2007	On the whole, our data show that quercetin sensitizes TRAIL-induced cytotoxicity in lung cancer cells through two independent pathways: induction of DR5 and suppression of survivin expression, which may underlie the mechanism of the lung cancer preventive activity of quercetin.	Quercetin	33-42	TNF superfamily member 10	Homo sapiens	54-59
17548900-9	2007	On the whole, our data show that quercetin sensitizes TRAIL-induced cytotoxicity in lung cancer cells through two independent pathways: induction of DR5 and suppression of survivin expression, which may underlie the mechanism of the lung cancer preventive activity of quercetin.	Quercetin	33-42	TNF receptor superfamily member 10b	Homo sapiens	149-152
17548900-9	2007	On the whole, our data show that quercetin sensitizes TRAIL-induced cytotoxicity in lung cancer cells through two independent pathways: induction of DR5 and suppression of survivin expression, which may underlie the mechanism of the lung cancer preventive activity of quercetin.	Quercetin	268-277	TNF superfamily member 10	Homo sapiens	54-59
17696131-7	2007	The silybin and quercetin group showed a decrease in level of ALT compared with MC-LR group but still higher than control group.	Quercetin	16-25	glutamic pyruvic transaminase, soluble	Mus musculus	62-65
17886198-3	2007	Against recombinant human MMP-1, flavonols such as quercetin and kaempferol were strong inhibitors with IC50 values of 39.6 and 43.7 microM, respectively, while flavones such as apigenin and wogonin showed only weak inhibitory activity.	Quercetin	51-60	matrix metallopeptidase 1	Homo sapiens	26-31
17886198-6	2007	Moreover, quercetin inhibited extracellular signal-regulated protein kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation, and kaempferol inhibited p38 MAPK and c-Jun N-terminal kinase (JNK) activation among the MAPKs tested.	Quercetin	10-19	mitogen-activated protein kinase 8	Homo sapiens	205-208
17559999-0	2007	Antioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase.	Quercetin	38-47	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	51-91
17559999-1	2007	Anti- and prooxidant properties of quercetin under different conditions were investigated using glyceraldehyde-3-phosphate dehydrogenase, a glycolytic enzyme containing essential cysteine residues.	Quercetin	35-44	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	96-136
17559999-3	2007	Quercetin significantly increased oxidation of GAPDH observed in the presence of ferrous ions, particularly when FeSO(4) was added to the solution containing GAPDH and quercetin.	Quercetin	0-9	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	47-52
17559999-3	2007	Quercetin significantly increased oxidation of GAPDH observed in the presence of ferrous ions, particularly when FeSO(4) was added to the solution containing GAPDH and quercetin.	Quercetin	0-9	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	158-163
17559999-3	2007	Quercetin significantly increased oxidation of GAPDH observed in the presence of ferrous ions, particularly when FeSO(4) was added to the solution containing GAPDH and quercetin.	Quercetin	168-177	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	47-52
17559999-5	2007	At the same time, quercetin protects GAPDH from oxidation in the presence of ascorbate and Fe(3+).	Quercetin	18-27	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	37-42
17559999-6	2007	In the absence of metals, quercetin protects SH-groups of GAPDH from oxidation by the superoxide anion generated by the system containing xanthine/xanthine oxidase.	Quercetin	26-35	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	58-63
17886198-8	2007	These results have shown, for the first time, that naturally-occurring flavonoids (quercetin, kaempferol, apigenin and wogonin) inhibit MMP-1 and down-regulate MMP-1 expression via an inhibition of the AP-1 activation although the cellular inhibitory mechanisms differ depending on their chemical structures.	Quercetin	83-92	matrix metallopeptidase 1	Homo sapiens	136-141
17886198-8	2007	These results have shown, for the first time, that naturally-occurring flavonoids (quercetin, kaempferol, apigenin and wogonin) inhibit MMP-1 and down-regulate MMP-1 expression via an inhibition of the AP-1 activation although the cellular inhibitory mechanisms differ depending on their chemical structures.	Quercetin	83-92	matrix metallopeptidase 1	Homo sapiens	160-165
17886198-8	2007	These results have shown, for the first time, that naturally-occurring flavonoids (quercetin, kaempferol, apigenin and wogonin) inhibit MMP-1 and down-regulate MMP-1 expression via an inhibition of the AP-1 activation although the cellular inhibitory mechanisms differ depending on their chemical structures.	Quercetin	83-92	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-206
17886198-4	2007	In addition, quercetin, kaempferol, apigenin and wogonin (12.5-25.0 microM) strongly inhibited MMP-1 induction in 12-O-tetradecanoylphorbol 13-acetate-treated human dermal fibroblasts, but naringenin (a flavanone) did not.	Quercetin	13-22	matrix metallopeptidase 1	Homo sapiens	95-100
17886198-6	2007	Moreover, quercetin inhibited extracellular signal-regulated protein kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation, and kaempferol inhibited p38 MAPK and c-Jun N-terminal kinase (JNK) activation among the MAPKs tested.	Quercetin	10-19	mitogen-activated protein kinase 1	Homo sapiens	30-75
17886198-6	2007	Moreover, quercetin inhibited extracellular signal-regulated protein kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation, and kaempferol inhibited p38 MAPK and c-Jun N-terminal kinase (JNK) activation among the MAPKs tested.	Quercetin	10-19	mitogen-activated protein kinase 1	Homo sapiens	77-80
17886198-6	2007	Moreover, quercetin inhibited extracellular signal-regulated protein kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation, and kaempferol inhibited p38 MAPK and c-Jun N-terminal kinase (JNK) activation among the MAPKs tested.	Quercetin	10-19	mitogen-activated protein kinase 14	Homo sapiens	86-122
17886198-6	2007	Moreover, quercetin inhibited extracellular signal-regulated protein kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) activation, and kaempferol inhibited p38 MAPK and c-Jun N-terminal kinase (JNK) activation among the MAPKs tested.	Quercetin	10-19	mitogen-activated protein kinase 1	Homo sapiens	124-128
18229606-6	2007	Compared with ADR 20 mg x kg(-1) group, the quercetin decreased the levels of LDH, iNOS, NO and MDA, increased the activity of SOD, restored the amplitude of R wave, decreased the incidence of arrhythmia and p53 expression (P &lt; 0.001 , P &lt; 0.01 or P &lt; 0.05), and markedly reduced the myocardial ultrastructure injury.	Quercetin	44-53	nitric oxide synthase 2, inducible	Mus musculus	83-87
18229606-6	2007	Compared with ADR 20 mg x kg(-1) group, the quercetin decreased the levels of LDH, iNOS, NO and MDA, increased the activity of SOD, restored the amplitude of R wave, decreased the incidence of arrhythmia and p53 expression (P &lt; 0.001 , P &lt; 0.01 or P &lt; 0.05), and markedly reduced the myocardial ultrastructure injury.	Quercetin	44-53	transformation related protein 53, pseudogene	Mus musculus	208-211
18007090-1	2007	OBJECTIVE: To investigate the antitumor effect and mechanism of quercetin on murine cervical carcinoma U14.	Quercetin	64-73	small nucleolar RNA, C/D box 14C	Mus musculus	103-106
18007090-14	2007	CONCLUSION: Quercetin showed a marked inhibitive effect on U14 growth, and its antitumor mechanism may be associated with inhibiting the angiogenesis and inducing apoptosis.	Quercetin	12-21	small nucleolar RNA, C/D box 14C	Mus musculus	59-62
17634198-8	2007	Treatment of the Caco-2 cells with live L. paracasei increased cellular levels of hsp70 and hsp27 and the potentiating effect on IL-6 production was inhibited by quercetin and by hsp70 or hsp27 siRNA.	Quercetin	162-171	interleukin 6	Homo sapiens	129-133
17876056-0	2007	Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	19-24
17643826-0	2007	Ecto-5"-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell line.	Quercetin	40-49	5'-nucleotidase ecto	Homo sapiens	0-20
17643826-0	2007	Ecto-5"-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell line.	Quercetin	40-49	5'-nucleotidase ecto	Homo sapiens	21-25
17643826-7	2007	Quercetin was able to inhibit the ecto-5"-NT/CD73 activity and modulate its expression.	Quercetin	0-9	5'-nucleotidase ecto	Homo sapiens	45-49
17630199-5	2007	Herein we characterize the effect of the flavonoids quercetin, genistein, luteolin, and quercetagetin on LPS-activated transduction mechanism regulation in human gingival fibroblasts (HGF).	Quercetin	52-61	hepatocyte growth factor	Homo sapiens	184-187
17995668-4	2007	TBP contained more quercetin (1710 mg/100 g) than BWP (5.4 mg/100 g), while there was a small difference in the contents of rutin between them.	Quercetin	19-28	TATA box binding protein	Mus musculus	0-3
17697041-5	2007	At the same time, quercetin at 12.5, 25 and 50 microM decreased malondialdehyde level, endothelin release and NF-kappaB expression, and increased superoxide dismutase activity, nitric oxide and 6-keto-prostaglandin F1alpha releases in homocysteine-injured ECV304 (P &lt; 0.05 or P &lt; 0.01 versus the homocysteine-injured group).	Quercetin	18-27	nuclear factor kappa B subunit 1	Homo sapiens	110-119
17458902-8	2007	Additionally, 3-OH flavone, baicalein, and quercetin showed effective inhibitory activities against E2/IGF-I-induced proliferation through suppressing proliferative events such as phosphorylation of IRS-1, ERKs, and JNKs proteins, and induction of c-Jun protein and colony formation.	Quercetin	43-52	cystatin 12, pseudogene	Homo sapiens	100-108
17458902-8	2007	Additionally, 3-OH flavone, baicalein, and quercetin showed effective inhibitory activities against E2/IGF-I-induced proliferation through suppressing proliferative events such as phosphorylation of IRS-1, ERKs, and JNKs proteins, and induction of c-Jun protein and colony formation.	Quercetin	43-52	insulin receptor substrate 1	Homo sapiens	199-204
17458902-8	2007	Additionally, 3-OH flavone, baicalein, and quercetin showed effective inhibitory activities against E2/IGF-I-induced proliferation through suppressing proliferative events such as phosphorylation of IRS-1, ERKs, and JNKs proteins, and induction of c-Jun protein and colony formation.	Quercetin	43-52	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	248-253
17876056-4	2007	In this study, we have investigated whether the flavonoid quercetin could sensitize human colon adenocarcinoma cell lines to TRAIL-induced apoptosis.	Quercetin	58-67	TNF superfamily member 10	Homo sapiens	125-130
17876056-5	2007	We report that quercetin enhanced TRAIL-induced apoptosis by causing the redistribution of DR4 and DR5 into lipid rafts.	Quercetin	15-24	TNF superfamily member 10	Homo sapiens	34-39
17876056-5	2007	We report that quercetin enhanced TRAIL-induced apoptosis by causing the redistribution of DR4 and DR5 into lipid rafts.	Quercetin	15-24	TNF receptor superfamily member 10a	Homo sapiens	91-94
17876056-5	2007	We report that quercetin enhanced TRAIL-induced apoptosis by causing the redistribution of DR4 and DR5 into lipid rafts.	Quercetin	15-24	TNF receptor superfamily member 10b	Homo sapiens	99-102
17876056-7	2007	In addition, our experiments show that quercetin, in combination with TRAIL, triggered the mitochondrial-dependent death pathway, as shown by Bid cleavage and the release of cytochrome c to the cytosol.	Quercetin	39-48	BH3 interacting domain death agonist	Homo sapiens	142-145
17876056-7	2007	In addition, our experiments show that quercetin, in combination with TRAIL, triggered the mitochondrial-dependent death pathway, as shown by Bid cleavage and the release of cytochrome c to the cytosol.	Quercetin	39-48	cytochrome c, somatic	Homo sapiens	174-186
17433488-0	2007	Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways.	Quercetin	0-9	heme oxygenase 1	Homo sapiens	87-103
17467952-7	2007	The characteristic electron spin resonance (ESR) signal of etoposide phenoxyl radical, which occurs in the presence of myeloperoxidase, H2O2 and etoposide, was quenched by quercetin in a dose-dependent manner (0.1-0.5 microM).	Quercetin	172-181	myeloperoxidase	Homo sapiens	119-134
17468513-3	2007	Since flavonoids are potent topoII inhibitors, we examined the role of three widely consumed dietary flavonoids (quercetin, genistein and kaempferol) on the development of MLL rearrangements in primary human CD34(+) cells.	Quercetin	113-122	lysine methyltransferase 2A	Homo sapiens	172-175
17652743-9	2007	RESULTS: DMSO (1% vol/vol) decreased cell viability, increased cellular apoptosis, and upregulated Bax in these cells; 0.1 microM quercetin inhibited these effects and protected HLECs from the toxicity of DMSO.	Quercetin	130-139	BCL2 associated X, apoptosis regulator	Homo sapiens	99-102
17652743-11	2007	In a dose-dependent response to quercetin, cellular apoptosis increased and the change correlated with upregulation of Bax and decreased cell viability.	Quercetin	32-41	BCL2 associated X, apoptosis regulator	Homo sapiens	119-122
17701137-9	2007	Experimental results on PLA2-inhibition showed good inhibitory activity for quercetin, kaempferol, and galangin, but relatively poor for naringenin.	Quercetin	76-85	phospholipase A2 group IB	Homo sapiens	24-28
17666819-7	2007	In addition, quercetin, morin, myricetin, kaempferol and puerarin exhibited significant inhibition on the liver xanthine oxidase (XOD) activities.	Quercetin	13-22	xanthine dehydrogenase	Mus musculus	112-128
17666819-7	2007	In addition, quercetin, morin, myricetin, kaempferol and puerarin exhibited significant inhibition on the liver xanthine oxidase (XOD) activities.	Quercetin	13-22	xanthine dehydrogenase	Mus musculus	130-133
17468513-8	2007	Beside MLL translocations, fluorescence in situ hybridization analysis demonstrated monosomy or trisomy of MLL in 8-10% of the quercetin-exposed CD34(+) cells.	Quercetin	127-136	lysine methyltransferase 2A	Homo sapiens	107-110
17468513-8	2007	Beside MLL translocations, fluorescence in situ hybridization analysis demonstrated monosomy or trisomy of MLL in 8-10% of the quercetin-exposed CD34(+) cells.	Quercetin	127-136	CD34 molecule	Homo sapiens	145-149
17433488-0	2007	Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	117-121
17433488-9	2007	SB203580 (p38 inhibitor) and especially PD98059 (ERK inhibitor) blocked quercetin-derived HO-1 induction and Nrf2 translocation, and subsequently inhibited the quercetin-related protection.	Quercetin	72-81	mitogen-activated protein kinase 14	Homo sapiens	10-13
17847711-5	2007	Flavonoids such as quercetin, fisetin and kaempferol exhibited high inhibitory potencies for 20alpha-HSD activity in liver cytosol, whereas these flavonoids were poor inhibitors for the enzyme activity in kidney cytosol.	Quercetin	19-28	aldo-keto reductase family 1, member C18	Mus musculus	93-104
17433488-9	2007	SB203580 (p38 inhibitor) and especially PD98059 (ERK inhibitor) blocked quercetin-derived HO-1 induction and Nrf2 translocation, and subsequently inhibited the quercetin-related protection.	Quercetin	72-81	mitogen-activated protein kinase 1	Homo sapiens	49-52
17433488-9	2007	SB203580 (p38 inhibitor) and especially PD98059 (ERK inhibitor) blocked quercetin-derived HO-1 induction and Nrf2 translocation, and subsequently inhibited the quercetin-related protection.	Quercetin	160-169	mitogen-activated protein kinase 14	Homo sapiens	10-13
17433488-9	2007	SB203580 (p38 inhibitor) and especially PD98059 (ERK inhibitor) blocked quercetin-derived HO-1 induction and Nrf2 translocation, and subsequently inhibited the quercetin-related protection.	Quercetin	160-169	mitogen-activated protein kinase 1	Homo sapiens	49-52
17433488-11	2007	Among MAPK signaling pathways, p38 and ERK mediated quercetin-derived Nrf2 translocation into nuclei and subsequent induction of HO-1 activity, and the latter showed a stronger mediating effect.	Quercetin	52-61	mitogen-activated protein kinase 14	Homo sapiens	31-34
17433488-11	2007	Among MAPK signaling pathways, p38 and ERK mediated quercetin-derived Nrf2 translocation into nuclei and subsequent induction of HO-1 activity, and the latter showed a stronger mediating effect.	Quercetin	52-61	mitogen-activated protein kinase 1	Homo sapiens	39-42
17433488-11	2007	Among MAPK signaling pathways, p38 and ERK mediated quercetin-derived Nrf2 translocation into nuclei and subsequent induction of HO-1 activity, and the latter showed a stronger mediating effect.	Quercetin	52-61	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
17666865-2	2007	Both rutin and quercetin (50 mg/kg x 2) improved spatial memory impairment in the 8-arm radial maze task and neuronal death in the hippocampal CA1 area; however, catechin (200 mg/kg x 2) and EGCG (50 mg/kg x 1) did not.	Quercetin	15-24	carbonic anhydrase 1	Rattus norvegicus	143-146
17543279-6	2007	Quercetin, an inhibitor of HSP70, blocked the effects of ghrelin on ASK1 activity.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	27-32
17543279-6	2007	Quercetin, an inhibitor of HSP70, blocked the effects of ghrelin on ASK1 activity.	Quercetin	0-9	ghrelin and obestatin prepropeptide	Rattus norvegicus	57-64
17543279-6	2007	Quercetin, an inhibitor of HSP70, blocked the effects of ghrelin on ASK1 activity.	Quercetin	0-9	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	68-72
17603933-0	2007	Inhibition of the peroxidation of linoleic acid by the flavonoid quercetin within their complex with human serum albumin.	Quercetin	65-74	albumin	Homo sapiens	107-120
17509533-0	2007	The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential.	Quercetin	14-23	ATP binding cassette subfamily C member 1	Homo sapiens	51-55
17509533-0	2007	The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential.	Quercetin	14-23	ATP binding cassette subfamily C member 2	Homo sapiens	60-64
17509533-1	2007	The present study characterises the effect of phase II metabolism, especially methylation and glucuronidation, of the model flavonoid quercetin on its capacity to inhibit human MRP1 and MRP2 activity in Sf9 inside-out vesicles.	Quercetin	134-143	ATP binding cassette subfamily C member 1	Homo sapiens	177-181
17509533-1	2007	The present study characterises the effect of phase II metabolism, especially methylation and glucuronidation, of the model flavonoid quercetin on its capacity to inhibit human MRP1 and MRP2 activity in Sf9 inside-out vesicles.	Quercetin	134-143	ATP binding cassette subfamily C member 2	Homo sapiens	186-190
17603933-1	2007	This work provides a quantitative kinetic analysis of oxidative pathways involving linoleic acid and the common dietary antioxidant quercetin (flavonoid), both bound to human serum albumin (HSA).	Quercetin	132-141	albumin	Homo sapiens	175-188
17509533-5	2007	Overall, the results of this study reveal that the major phase II metabolites of quercetin are equally potent or even better inhibitors of human MRP1 and MRP2 than quercetin itself.	Quercetin	81-90	ATP binding cassette subfamily C member 1	Homo sapiens	145-149
17588336-8	2007	Moreover, quercetin, an inhibitor of HSP70 expression, aggravated the infiltration of inflammatory cells and glandular loss in the antrum.	Quercetin	10-19	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	37-42
17509533-5	2007	Overall, the results of this study reveal that the major phase II metabolites of quercetin are equally potent or even better inhibitors of human MRP1 and MRP2 than quercetin itself.	Quercetin	81-90	ATP binding cassette subfamily C member 2	Homo sapiens	154-158
17509533-6	2007	This finding indicates that phase II metabolism of quercetin could enhance the potential use of quercetin- or flavonoids in general-as an inhibitor to overcome MRP-mediated multidrug resistance.	Quercetin	51-60	ATP binding cassette subfamily C member 1	Homo sapiens	160-163
17509533-6	2007	This finding indicates that phase II metabolism of quercetin could enhance the potential use of quercetin- or flavonoids in general-as an inhibitor to overcome MRP-mediated multidrug resistance.	Quercetin	96-105	ATP binding cassette subfamily C member 1	Homo sapiens	160-163
17477920-0	2007	Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-gamma.	Quercetin	10-19	interferon gamma	Homo sapiens	85-94
17477920-2	2007	We have studied the effect of the lycopene, quercetin and tyrosol natural antioxidants on the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 macrophages stimulated by gliadin in association with IFN-gamma.	Quercetin	44-53	nitric oxide synthase 2	Homo sapiens	127-131
17477920-3	2007	The IFN-gamma plus gliadin combination treatment was capable of enhancing iNOS and COX-2 gene expression and nuclear factor-kappaB (NF-kappaB), interferon regulatory factor-1 (IRF-1) and signal transducer and activator of transcription-1alpha (STAT-1alpha) activation induced by reactive oxygen species generation at 24 h. Lycopene, quercetin and tyrosol inhibited all these effects.	Quercetin	333-342	interferon gamma	Homo sapiens	4-13
17359941-8	2007	The formation of MGN glucuronidation by human liver microsomes was effectively inhibited by quercetin (substrate for UGT1A3) and diclofenac (substrate for UGT2B7), respectively.	Quercetin	92-101	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	117-123
17581220-2	2007	The present study was designed to determine the effects of ginkgolide A, ginkgolide B and quercetin on CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes.	Quercetin	90-99	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	103-108
17637178-10	2007	Whereas most unmethylated polyphenols, such as curcumin and quercetin, have very poor bioavailability, the high metabolic stability of the methoxylated flavones studied here suggests that these CYP1B1 inhibitors may also be effective in-vivo.	Quercetin	60-69	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	194-200
17462537-0	2007	Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin.	Quercetin	60-69	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
17462537-0	2007	Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin.	Quercetin	60-69	kelch like ECH associated protein 1	Homo sapiens	19-24
17462537-0	2007	Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin.	Quercetin	60-69	NAD(P)H quinone dehydrogenase 1	Homo sapiens	41-45
17462537-4	2007	Quercetin enhanced the ARE binding activity and Nrf2-mediated transcription activity.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52
17462537-5	2007	Molecular evidence revealed that quercetin not only up-regulated the expression of Nrf2 mRNA and protein, but also stabilized Nrf2 protein by inhibiting the ubiquitination and proteasomal turnover of Nrf2.	Quercetin	33-42	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
17462537-5	2007	Molecular evidence revealed that quercetin not only up-regulated the expression of Nrf2 mRNA and protein, but also stabilized Nrf2 protein by inhibiting the ubiquitination and proteasomal turnover of Nrf2.	Quercetin	33-42	NFE2 like bZIP transcription factor 2	Homo sapiens	126-130
17462537-5	2007	Molecular evidence revealed that quercetin not only up-regulated the expression of Nrf2 mRNA and protein, but also stabilized Nrf2 protein by inhibiting the ubiquitination and proteasomal turnover of Nrf2.	Quercetin	33-42	NFE2 like bZIP transcription factor 2	Homo sapiens	126-130
17462537-6	2007	At the same time, quercetin markedly reduced the level of Keap1 protein in posttranslational levels through the formation of modified Keap1 protein, rather than 26S proteasome-dependent degradation mechanisms, without affecting the dissociation of Keap1-Nrf2.	Quercetin	18-27	kelch like ECH associated protein 1	Homo sapiens	58-63
17462537-6	2007	At the same time, quercetin markedly reduced the level of Keap1 protein in posttranslational levels through the formation of modified Keap1 protein, rather than 26S proteasome-dependent degradation mechanisms, without affecting the dissociation of Keap1-Nrf2.	Quercetin	18-27	kelch like ECH associated protein 1	Homo sapiens	134-139
17462537-6	2007	At the same time, quercetin markedly reduced the level of Keap1 protein in posttranslational levels through the formation of modified Keap1 protein, rather than 26S proteasome-dependent degradation mechanisms, without affecting the dissociation of Keap1-Nrf2.	Quercetin	18-27	kelch like ECH associated protein 1	Homo sapiens	134-139
17462537-6	2007	At the same time, quercetin markedly reduced the level of Keap1 protein in posttranslational levels through the formation of modified Keap1 protein, rather than 26S proteasome-dependent degradation mechanisms, without affecting the dissociation of Keap1-Nrf2.	Quercetin	18-27	NFE2 like bZIP transcription factor 2	Homo sapiens	254-258
17462537-7	2007	Silencing Keap1 using Keap1 siRNA significantly increased the Nrf2-dependent ARE activity, whereas silencing Nrf2 using Nrf2 siRNA markedly reduced the ARE activity under both baseline and quercetin-induced conditions.	Quercetin	189-198	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
17462537-7	2007	Silencing Keap1 using Keap1 siRNA significantly increased the Nrf2-dependent ARE activity, whereas silencing Nrf2 using Nrf2 siRNA markedly reduced the ARE activity under both baseline and quercetin-induced conditions.	Quercetin	189-198	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
17462537-8	2007	Thus, we conclude that the pathway of quercetin-induced ARE activity involves up-regulation of Nrf2 through the regulation of both transcription and posttranscription sites and repression of Keap1 by affecting the posttranscription site, revealing some substantial differences between oxidative inducers.	Quercetin	38-47	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
17462537-8	2007	Thus, we conclude that the pathway of quercetin-induced ARE activity involves up-regulation of Nrf2 through the regulation of both transcription and posttranscription sites and repression of Keap1 by affecting the posttranscription site, revealing some substantial differences between oxidative inducers.	Quercetin	38-47	kelch like ECH associated protein 1	Homo sapiens	191-196
17243115-0	2007	Effects of quercetin and quercetin 3-glucuronide on the expression of bone sialoprotein gene.	Quercetin	11-20	integrin-binding sialoprotein	Rattus norvegicus	70-87
17243115-4	2007	The present study investigates the regulation of BSP transcription in a rat osteoblast-like cell line, ROS 17/2.8 cells, by quercetin and its conjugated metabolite quercetin 3-glucuronide.	Quercetin	124-133	integrin-binding sialoprotein	Rattus norvegicus	49-52
17243115-5	2007	Quercetin and quercetin 3-glucuronide (5 microM) increased the BSP mRNA levels at 12 h and quercetin upregulated the Cbfa1/Runx2 mRNA expression at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, quercetin increased the luciferase activity of the construct (pLUC3), including the promoter sequence nucleotides -116 to -43.	Quercetin	0-9	integrin-binding sialoprotein	Rattus norvegicus	63-66
17243115-5	2007	Quercetin and quercetin 3-glucuronide (5 microM) increased the BSP mRNA levels at 12 h and quercetin upregulated the Cbfa1/Runx2 mRNA expression at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, quercetin increased the luciferase activity of the construct (pLUC3), including the promoter sequence nucleotides -116 to -43.	Quercetin	0-9	RUNX family transcription factor 2	Rattus norvegicus	117-122
17243115-5	2007	Quercetin and quercetin 3-glucuronide (5 microM) increased the BSP mRNA levels at 12 h and quercetin upregulated the Cbfa1/Runx2 mRNA expression at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, quercetin increased the luciferase activity of the construct (pLUC3), including the promoter sequence nucleotides -116 to -43.	Quercetin	0-9	RUNX family transcription factor 2	Rattus norvegicus	123-128
17243115-5	2007	Quercetin and quercetin 3-glucuronide (5 microM) increased the BSP mRNA levels at 12 h and quercetin upregulated the Cbfa1/Runx2 mRNA expression at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, quercetin increased the luciferase activity of the construct (pLUC3), including the promoter sequence nucleotides -116 to -43.	Quercetin	0-9	integrin-binding sialoprotein	Rattus norvegicus	209-212
17243115-5	2007	Quercetin and quercetin 3-glucuronide (5 microM) increased the BSP mRNA levels at 12 h and quercetin upregulated the Cbfa1/Runx2 mRNA expression at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, quercetin increased the luciferase activity of the construct (pLUC3), including the promoter sequence nucleotides -116 to -43.	Quercetin	14-23	integrin-binding sialoprotein	Rattus norvegicus	63-66
17243115-5	2007	Quercetin and quercetin 3-glucuronide (5 microM) increased the BSP mRNA levels at 12 h and quercetin upregulated the Cbfa1/Runx2 mRNA expression at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, quercetin increased the luciferase activity of the construct (pLUC3), including the promoter sequence nucleotides -116 to -43.	Quercetin	14-23	RUNX family transcription factor 2	Rattus norvegicus	123-128
17243115-5	2007	Quercetin and quercetin 3-glucuronide (5 microM) increased the BSP mRNA levels at 12 h and quercetin upregulated the Cbfa1/Runx2 mRNA expression at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, quercetin increased the luciferase activity of the construct (pLUC3), including the promoter sequence nucleotides -116 to -43.	Quercetin	14-23	integrin-binding sialoprotein	Rattus norvegicus	209-212
17243115-5	2007	Quercetin and quercetin 3-glucuronide (5 microM) increased the BSP mRNA levels at 12 h and quercetin upregulated the Cbfa1/Runx2 mRNA expression at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, quercetin increased the luciferase activity of the construct (pLUC3), including the promoter sequence nucleotides -116 to -43.	Quercetin	91-100	RUNX family transcription factor 2	Rattus norvegicus	117-122
17243115-5	2007	Quercetin and quercetin 3-glucuronide (5 microM) increased the BSP mRNA levels at 12 h and quercetin upregulated the Cbfa1/Runx2 mRNA expression at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, quercetin increased the luciferase activity of the construct (pLUC3), including the promoter sequence nucleotides -116 to -43.	Quercetin	91-100	RUNX family transcription factor 2	Rattus norvegicus	123-128
17243115-5	2007	Quercetin and quercetin 3-glucuronide (5 microM) increased the BSP mRNA levels at 12 h and quercetin upregulated the Cbfa1/Runx2 mRNA expression at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, quercetin increased the luciferase activity of the construct (pLUC3), including the promoter sequence nucleotides -116 to -43.	Quercetin	91-100	integrin-binding sialoprotein	Rattus norvegicus	209-212
17243115-8	2007	These data suggest that quercetin and quercetin 3-glucuronide increased the BSP mRNA expression, and that the inverted CCAAT and FRE elements in the promoter of the BSP gene are required for quercetin induced BSP transcription.	Quercetin	24-33	integrin-binding sialoprotein	Rattus norvegicus	76-79
17243115-8	2007	These data suggest that quercetin and quercetin 3-glucuronide increased the BSP mRNA expression, and that the inverted CCAAT and FRE elements in the promoter of the BSP gene are required for quercetin induced BSP transcription.	Quercetin	24-33	integrin-binding sialoprotein	Rattus norvegicus	165-168
17243115-8	2007	These data suggest that quercetin and quercetin 3-glucuronide increased the BSP mRNA expression, and that the inverted CCAAT and FRE elements in the promoter of the BSP gene are required for quercetin induced BSP transcription.	Quercetin	24-33	integrin-binding sialoprotein	Rattus norvegicus	165-168
17243115-8	2007	These data suggest that quercetin and quercetin 3-glucuronide increased the BSP mRNA expression, and that the inverted CCAAT and FRE elements in the promoter of the BSP gene are required for quercetin induced BSP transcription.	Quercetin	38-47	integrin-binding sialoprotein	Rattus norvegicus	76-79
17243115-8	2007	These data suggest that quercetin and quercetin 3-glucuronide increased the BSP mRNA expression, and that the inverted CCAAT and FRE elements in the promoter of the BSP gene are required for quercetin induced BSP transcription.	Quercetin	38-47	integrin-binding sialoprotein	Rattus norvegicus	165-168
17243115-8	2007	These data suggest that quercetin and quercetin 3-glucuronide increased the BSP mRNA expression, and that the inverted CCAAT and FRE elements in the promoter of the BSP gene are required for quercetin induced BSP transcription.	Quercetin	38-47	integrin-binding sialoprotein	Rattus norvegicus	165-168
17388968-4	2007	RESULTS: Among the wine phenolics tested, quercetin and resveratrol, in a dose-dependent manner, suppressed cytokine-induced CRP expression.	Quercetin	42-51	C-reactive protein	Homo sapiens	125-128
17293380-10	2007	Altered cellular proliferation was observed in MCF-7 cells stably expressing SULT1E1 upon treatment with chrysin, quercetin, or resveratrol, thus suggesting inactivation of these compounds by SULT1E1.	Quercetin	114-123	sulfotransferase family 1E member 1	Homo sapiens	77-84
17377063-0	2007	Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-75
17377063-0	2007	Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase.	Quercetin	0-9	vascular endothelial growth factor A	Homo sapiens	76-110
17377063-0	2007	Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase.	Quercetin	175-184	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-75
17377063-2	2007	Quercetin up-regulated vascular endothelial growth factor (VEGF), an ulcer healing factor, not only in colon epithelial cell lines but also in the inflamed colonic tissue.	Quercetin	0-9	vascular endothelial growth factor A	Homo sapiens	23-57
17377063-2	2007	Quercetin up-regulated vascular endothelial growth factor (VEGF), an ulcer healing factor, not only in colon epithelial cell lines but also in the inflamed colonic tissue.	Quercetin	0-9	vascular endothelial growth factor A	Homo sapiens	59-63
17377063-3	2007	VEGF derived from quercetin-treated colon epithelial cells promoted tube formation.	Quercetin	18-27	vascular endothelial growth factor A	Homo sapiens	0-4
17377063-4	2007	The VEGF induction was dependent on quercetin-mediated hypoxia-inducible factor-1 (HIF-1) activation.	Quercetin	36-45	vascular endothelial growth factor A	Homo sapiens	4-8
17377063-4	2007	The VEGF induction was dependent on quercetin-mediated hypoxia-inducible factor-1 (HIF-1) activation.	Quercetin	36-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-81
17377063-4	2007	The VEGF induction was dependent on quercetin-mediated hypoxia-inducible factor-1 (HIF-1) activation.	Quercetin	36-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-88
17377063-5	2007	Quercetin delayed HIF-1alpha protein disappearance, which occurred by inhibiting HIF-prolyl hydroxylase (HPH), the key enzyme for HIF-1alpha hydroxylation and subsequent von Hippel Lindau-dependent HIF-1alpha degradation.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
17377063-5	2007	Quercetin delayed HIF-1alpha protein disappearance, which occurred by inhibiting HIF-prolyl hydroxylase (HPH), the key enzyme for HIF-1alpha hydroxylation and subsequent von Hippel Lindau-dependent HIF-1alpha degradation.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-140
17377063-7	2007	Consistent with this, cellular induction of HIF-1alpha by quercetin was abolished by pretreatment with iron.	Quercetin	58-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
17377063-8	2007	Two iron-chelating moieties in quercetin, -OH at position 3 of the C ring and/or -OH at positions 3" and 4" of the B ring, enabled the flavonoid to inhibit HPH and subsequently induce HIF-1alpha.	Quercetin	31-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	184-194
17377063-9	2007	Our data suggest that the clinical effect of quercetin may be partly attributed to the activation of an angiogenic pathway HIF-1-VEGF via inhibiting HPH and the chelating moieties of quercetin were required for inhibiting HPH.	Quercetin	45-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
17376580-7	2007	The subcellular distribution of the FoxO transcription factor DAF-16 was only affected by quercetin indicating a modulatory effect of quercetin on signalling cascade(s).	Quercetin	90-99	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	62-68
17376580-7	2007	The subcellular distribution of the FoxO transcription factor DAF-16 was only affected by quercetin indicating a modulatory effect of quercetin on signalling cascade(s).	Quercetin	134-143	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	62-68
17478321-6	2007	Fl-labeled clot lysis in ApoE knock-out mice (atherosclerosis model) showed impaired in vivo clot lysis that was "normalized" to wild-type control levels by treatment with alcohol, catechin, or quercetin for 6 to 8 weeks.	Quercetin	194-203	apolipoprotein E	Mus musculus	25-29
17293380-10	2007	Altered cellular proliferation was observed in MCF-7 cells stably expressing SULT1E1 upon treatment with chrysin, quercetin, or resveratrol, thus suggesting inactivation of these compounds by SULT1E1.	Quercetin	114-123	sulfotransferase family 1E member 1	Homo sapiens	192-199
17293380-4	2007	The enzyme kinetics of SULT1A1 allozymes and SULT1E1 were characterized for the polyphenolic substrates apigenin, chrysin, epicatechin, quercetin, and resveratrol.	Quercetin	136-145	sulfotransferase family 1A member 1	Homo sapiens	23-30
17293380-4	2007	The enzyme kinetics of SULT1A1 allozymes and SULT1E1 were characterized for the polyphenolic substrates apigenin, chrysin, epicatechin, quercetin, and resveratrol.	Quercetin	136-145	sulfotransferase family 1E member 1	Homo sapiens	45-52
16963249-9	2007	In addition, pretreatment with quercetin (one as a JNK inhibitor and one as an antioxidant) significantly reduced the cell death rate and JNK and SEK-1 activities.	Quercetin	31-40	mitogen-activated protein kinase 8	Homo sapiens	51-54
17614721-1	2007	Human serum albumin (HSA) complexation with quercetin, a flavonoid commonly present in human diet, was monitored by means of fluorescence decays of the single HSA tryptophan - Trp214.	Quercetin	44-53	albumin	Homo sapiens	6-19
17588137-0	2007	Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	93-96
17588137-5	2007	RESULTS: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells.	Quercetin	9-18	tumor necrosis factor	Homo sapiens	67-100
17588137-5	2007	RESULTS: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells.	Quercetin	9-18	interleukin 1 beta	Homo sapiens	102-124
17588137-5	2007	RESULTS: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells.	Quercetin	9-18	interleukin 6	Homo sapiens	126-130
17588137-5	2007	RESULTS: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells.	Quercetin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
17588137-6	2007	Quercetin attenuated PMACI-induced activation of NF-kappaB and p38 mitogen-activated protein kinase.	Quercetin	0-9	mitogen-activated protein kinase 14	Homo sapiens	63-66
16963249-9	2007	In addition, pretreatment with quercetin (one as a JNK inhibitor and one as an antioxidant) significantly reduced the cell death rate and JNK and SEK-1 activities.	Quercetin	31-40	mitogen-activated protein kinase 8	Homo sapiens	138-141
17449583-0	2007	Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells.	Quercetin	0-9	tumor necrosis factor	Mus musculus	19-22
17449583-8	2007	The oral application of quercetin to heterozygous TNFDeltaARE/WT mice [10 mg/(d x kg body wt)] significantly inhibited IP-10 and MIP-2 gene expression in primary ileal epithelial cells but did not affect tissue pathology.	Quercetin	24-33	chemokine (C-X-C motif) ligand 10	Mus musculus	119-124
16963249-9	2007	In addition, pretreatment with quercetin (one as a JNK inhibitor and one as an antioxidant) significantly reduced the cell death rate and JNK and SEK-1 activities.	Quercetin	31-40	mitogen-activated protein kinase kinase 4	Homo sapiens	146-151
17449583-8	2007	The oral application of quercetin to heterozygous TNFDeltaARE/WT mice [10 mg/(d x kg body wt)] significantly inhibited IP-10 and MIP-2 gene expression in primary ileal epithelial cells but did not affect tissue pathology.	Quercetin	24-33	chemokine (C-X-C motif) ligand 2	Mus musculus	129-134
17449583-2	2007	In this study, we characterized the molecular mechanisms by which quercetin and its enteric bacterial metabolites, taxifolin, alphitonin, and 3, 4-dihydroxy-phenylacetic acid, inhibit tumor necrosis factor alpha (TNF)-induced proinflammatory gene expression in the murine small intestinal epithelial cell (IEC) line Mode-K as well as in heterozygous TNFDeltaARE/WT mice, a murine model of experimental ileitis.	Quercetin	66-75	tumor necrosis factor	Mus musculus	184-211
17449583-2	2007	In this study, we characterized the molecular mechanisms by which quercetin and its enteric bacterial metabolites, taxifolin, alphitonin, and 3, 4-dihydroxy-phenylacetic acid, inhibit tumor necrosis factor alpha (TNF)-induced proinflammatory gene expression in the murine small intestinal epithelial cell (IEC) line Mode-K as well as in heterozygous TNFDeltaARE/WT mice, a murine model of experimental ileitis.	Quercetin	66-75	tumor necrosis factor	Mus musculus	213-216
17330100-0	2007	Quercetin enhances CD95- and TRAIL-induced apoptosis in leukemia cell lines.	Quercetin	0-9	Fas cell surface death receptor	Homo sapiens	19-23
17449583-3	2007	Quercetin inhibited TNF-induced interferon-gamma-inducible protein 10 (IP-10) and macrophage inflammatory protein 2 (MIP-2) gene expression in Mode-K cells with effective inhibitory concentration of 40 and 44 micromol/L, respectively.	Quercetin	0-9	tumor necrosis factor	Mus musculus	20-23
17449583-3	2007	Quercetin inhibited TNF-induced interferon-gamma-inducible protein 10 (IP-10) and macrophage inflammatory protein 2 (MIP-2) gene expression in Mode-K cells with effective inhibitory concentration of 40 and 44 micromol/L, respectively.	Quercetin	0-9	chemokine (C-X-C motif) ligand 10	Mus musculus	32-69
17449583-3	2007	Quercetin inhibited TNF-induced interferon-gamma-inducible protein 10 (IP-10) and macrophage inflammatory protein 2 (MIP-2) gene expression in Mode-K cells with effective inhibitory concentration of 40 and 44 micromol/L, respectively.	Quercetin	0-9	chemokine (C-X-C motif) ligand 10	Mus musculus	71-76
17449583-3	2007	Quercetin inhibited TNF-induced interferon-gamma-inducible protein 10 (IP-10) and macrophage inflammatory protein 2 (MIP-2) gene expression in Mode-K cells with effective inhibitory concentration of 40 and 44 micromol/L, respectively.	Quercetin	0-9	chemokine (C-X-C motif) ligand 2	Mus musculus	82-115
17449583-3	2007	Quercetin inhibited TNF-induced interferon-gamma-inducible protein 10 (IP-10) and macrophage inflammatory protein 2 (MIP-2) gene expression in Mode-K cells with effective inhibitory concentration of 40 and 44 micromol/L, respectively.	Quercetin	0-9	chemokine (C-X-C motif) ligand 2	Mus musculus	117-122
17449583-6	2007	Most important for understanding the mechanism involved, chromatin immunoprecipitation analysis revealed inhibitory effects of quercetin on phospho-RelA recruitment to the IP-10 and MIP-2 gene promoters.	Quercetin	127-136	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	148-152
17449583-6	2007	Most important for understanding the mechanism involved, chromatin immunoprecipitation analysis revealed inhibitory effects of quercetin on phospho-RelA recruitment to the IP-10 and MIP-2 gene promoters.	Quercetin	127-136	chemokine (C-X-C motif) ligand 10	Mus musculus	172-177
17449583-6	2007	Most important for understanding the mechanism involved, chromatin immunoprecipitation analysis revealed inhibitory effects of quercetin on phospho-RelA recruitment to the IP-10 and MIP-2 gene promoters.	Quercetin	127-136	chemokine (C-X-C motif) ligand 2	Mus musculus	182-187
17330100-0	2007	Quercetin enhances CD95- and TRAIL-induced apoptosis in leukemia cell lines.	Quercetin	0-9	TNF superfamily member 10	Homo sapiens	29-34
21179752-1	2007	AIM: To investigate the effect of extract of ginkgo biloba (EGb) and quercetin (Que) on the hypertrophic response induced by angiotensin II (Ang II) in the primary culture of neonatal rat cardiomyocytes and its mechanism.	Quercetin	69-78	angiotensinogen	Rattus norvegicus	141-147
17867494-4	2007	It was found that heat stress (43 degrees C, 30 min) increased the HSP level in normal fibroblasts and improved their survival following exposure to gamma-radiation, with both the effects being suppressed by quercetin (an inhibitor of HSF1-mediated HSP induction).	Quercetin	208-217	heat shock protein 1B	Mus musculus	67-70
17867494-4	2007	It was found that heat stress (43 degrees C, 30 min) increased the HSP level in normal fibroblasts and improved their survival following exposure to gamma-radiation, with both the effects being suppressed by quercetin (an inhibitor of HSF1-mediated HSP induction).	Quercetin	208-217	heat shock factor 1	Mus musculus	235-239
17867494-4	2007	It was found that heat stress (43 degrees C, 30 min) increased the HSP level in normal fibroblasts and improved their survival following exposure to gamma-radiation, with both the effects being suppressed by quercetin (an inhibitor of HSF1-mediated HSP induction).	Quercetin	208-217	heat shock protein 1B	Mus musculus	249-252
21179752-10	2007	CONCLUSION: EGb and Que could inhibit AngII-induced cardiomyocyte hypertrophy through a ROS-dependent pathway, the effect of Que might be related to the JNK and c-fos cascade.	Quercetin	20-23	angiotensinogen	Rattus norvegicus	38-43
21179752-10	2007	CONCLUSION: EGb and Que could inhibit AngII-induced cardiomyocyte hypertrophy through a ROS-dependent pathway, the effect of Que might be related to the JNK and c-fos cascade.	Quercetin	20-23	mitogen-activated protein kinase 8	Rattus norvegicus	153-156
21179752-10	2007	CONCLUSION: EGb and Que could inhibit AngII-induced cardiomyocyte hypertrophy through a ROS-dependent pathway, the effect of Que might be related to the JNK and c-fos cascade.	Quercetin	20-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	161-166
21179752-9	2007	(4) EGb, Que, Captopril and DPI all decreased Ang II-stimulated early response gent c-fos mnRNA expression.	Quercetin	9-12	angiotensinogen	Rattus norvegicus	46-52
21179752-9	2007	(4) EGb, Que, Captopril and DPI all decreased Ang II-stimulated early response gent c-fos mnRNA expression.	Quercetin	9-12	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-89
17077187-9	2007	Caco-2 cells pretreated with quercetin or DBM showed an enhancement of apically transported benzo[a]pyrene-3-sulfate, indicating that induced BCRP was functionally active.	Quercetin	29-38	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	142-146
17292933-8	2007	Quercetin inhibited both BaP-mediated effects on Prx I and II in 22Rv1 cells.	Quercetin	0-9	prohibitin 2	Homo sapiens	25-28
17292933-8	2007	Quercetin inhibited both BaP-mediated effects on Prx I and II in 22Rv1 cells.	Quercetin	0-9	peroxiredoxin 2	Homo sapiens	49-61
17292933-9	2007	In PrEC cells, quercetin inhibited BaP-mediated upregulation of Prx I and had tendency to neutralize BaP-mediated downregulation of Prx II.	Quercetin	15-24	prohibitin 2	Homo sapiens	35-38
17292933-9	2007	In PrEC cells, quercetin inhibited BaP-mediated upregulation of Prx I and had tendency to neutralize BaP-mediated downregulation of Prx II.	Quercetin	15-24	prohibitin 2	Homo sapiens	101-104
17292933-10	2007	Quercetin also inhibited BaP-induced concentrations of reactive oxygen species in both 22Rv1 and PrEC cells.	Quercetin	0-9	prohibitin 2	Homo sapiens	25-28
17292933-11	2007	These results suggest that Prx I and II may be involved in BaP-mediated toxicity and the potential chemopreventative mechanisms of quercetin.	Quercetin	131-140	peroxiredoxin 1	Homo sapiens	27-39
17374653-0	2007	Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta.	Quercetin	0-9	neutrophil cytosolic factor 1	Rattus norvegicus	105-112
17374653-0	2007	Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta.	Quercetin	0-9	angiotensinogen	Rattus norvegicus	124-138
17374653-4	2007	At 6 h, AngII induced a marked increase in O(2)(-) production as measured by dihydroethidium fluorescence, which was prevented by quercetin and isorhamnetin.	Quercetin	130-139	angiotensinogen	Rattus norvegicus	8-13
17374653-7	2007	p47(phox) overexpression was also prevented by quercetin and isorhamnetin.	Quercetin	47-56	NSFL1 cofactor	Rattus norvegicus	0-3
17374653-8	2007	Taken together, these results show for the first time, to our knowledge, that quercetin and isorhamnetin prevent AngII-induced endothelial dysfunction by inhibiting the overexpression of p47(phox) and the subsequent increased O(2)(-) production, resulting in increased nitric oxide bioavailability.	Quercetin	78-87	angiotensinogen	Rattus norvegicus	113-118
17374653-8	2007	Taken together, these results show for the first time, to our knowledge, that quercetin and isorhamnetin prevent AngII-induced endothelial dysfunction by inhibiting the overexpression of p47(phox) and the subsequent increased O(2)(-) production, resulting in increased nitric oxide bioavailability.	Quercetin	78-87	NSFL1 cofactor	Rattus norvegicus	187-190
17520098-0	2007	Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2).	Quercetin	0-9	H3 histone pseudogene 16	Homo sapiens	72-75
17520098-0	2007	Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2).	Quercetin	0-9	interferon alpha inducible protein 27	Homo sapiens	80-83
17520098-6	2007	Furthermore, the results indicate that quercetin increased the content of Cdk inhibitor p21 protein, which was correlated with the elevation in p53 levels during 12 h of incubation.	Quercetin	39-48	H3 histone pseudogene 16	Homo sapiens	88-91
17520098-6	2007	Furthermore, the results indicate that quercetin increased the content of Cdk inhibitor p21 protein, which was correlated with the elevation in p53 levels during 12 h of incubation.	Quercetin	39-48	tumor protein p53	Homo sapiens	144-147
17520098-7	2007	In addition, quercetin also increased the level of Cdk inhibitor p27 protein during 24 h of incubation.	Quercetin	13-22	interferon alpha inducible protein 27	Homo sapiens	65-68
17520098-8	2007	From our results it can be concluded that quercetin blocks cell cycle progression at G(1) phase and exerts its growth-inhibitory effect through the increase of Cdk inhibitors p21 and p27 and tumor suppressor p53 in HepG2.	Quercetin	42-51	H3 histone pseudogene 16	Homo sapiens	175-178
17520098-8	2007	From our results it can be concluded that quercetin blocks cell cycle progression at G(1) phase and exerts its growth-inhibitory effect through the increase of Cdk inhibitors p21 and p27 and tumor suppressor p53 in HepG2.	Quercetin	42-51	interferon alpha inducible protein 27	Homo sapiens	183-186
17520098-8	2007	From our results it can be concluded that quercetin blocks cell cycle progression at G(1) phase and exerts its growth-inhibitory effect through the increase of Cdk inhibitors p21 and p27 and tumor suppressor p53 in HepG2.	Quercetin	42-51	tumor protein p53	Homo sapiens	208-211
17077187-4	2007	In Caco-2 cells, the most pronounced induction of BCRP expression could be observed after treatment with TBHQ (100 microM), dibenzoylmethane (DBM, 50 microM), and quercetin (25 microM), while green tea component (-)-epicatechin (50 microM) decreased BCRP expression.	Quercetin	163-172	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	50-54
17364964-0	2007	The flavonoid quercetin induces hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits cell proliferation by depleting intracellular iron.	Quercetin	14-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-63
17313705-5	2007	In addition, quercetin and luteolin significantly attenuated expression of LOX-1 protein up regulated in oxidised LDL-activated HUVEC with a fall in transcriptional mRNA levels of LOX-1.	Quercetin	13-22	oxidized low density lipoprotein receptor 1	Homo sapiens	75-80
17313705-5	2007	In addition, quercetin and luteolin significantly attenuated expression of LOX-1 protein up regulated in oxidised LDL-activated HUVEC with a fall in transcriptional mRNA levels of LOX-1.	Quercetin	13-22	oxidized low density lipoprotein receptor 1	Homo sapiens	180-185
17141727-3	2007	The flavonols rutin, quercetin, myricetin, and kaempferol inhibited the inactivation of alpha1-antitrypsin by HOCl and HOBr with rutin having the most pronounced effect.	Quercetin	21-30	serpin family A member 1	Homo sapiens	88-106
17364964-0	2007	The flavonoid quercetin induces hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits cell proliferation by depleting intracellular iron.	Quercetin	14-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-75
17364964-1	2007	Quercetin, a flavonoid with anti-oxidant, metal chelating, kinase modulating and anti-proliferative properties, can induce hypoxia-inducible factor-1alpha (HIF-1alpha) in normoxia, but its mechanism of action has not been determined.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-154
17364964-1	2007	Quercetin, a flavonoid with anti-oxidant, metal chelating, kinase modulating and anti-proliferative properties, can induce hypoxia-inducible factor-1alpha (HIF-1alpha) in normoxia, but its mechanism of action has not been determined.	Quercetin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-166
17364964-3	2007	Furthermore, we investigated the relevance of the intracellular levels of quercetin to HIF-1alpha expression and cell proliferation.	Quercetin	74-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
17364964-4	2007	Our data demonstrate that quercetin depletes intracellular calcein-chelatable iron and that supplying additional iron from extracellular or intracellular pools abrogates the induction of HIF-1alpha by quercetin.	Quercetin	201-210	hypoxia inducible factor 1 subunit alpha	Homo sapiens	187-197
17364964-6	2007	We propose that quercetin stabilises HIF-1alpha and inhibits cell proliferation predominantly by decreasing the concentration of intracellular iron through chelation.	Quercetin	16-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
17031854-0	2007	TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation.	Quercetin	31-40	TNF superfamily member 10	Homo sapiens	0-5
17031854-0	2007	TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation.	Quercetin	31-40	AKT serine/threonine kinase 1	Homo sapiens	49-52
17031854-3	2007	Here we demonstrated that human prostate cancer cells, but not normal prostate cells, are dramatically sensitized to TRAIL-induced apoptosis and caspase activation by quercetin.	Quercetin	167-176	TNF superfamily member 10	Homo sapiens	117-122
17031854-5	2007	We have shown that quercetin can potentiate TRAIL-induced apoptotic death.	Quercetin	19-28	TNF superfamily member 10	Homo sapiens	44-49
17031854-7	2007	The TRAIL-mediated activation of caspase, and PARP (poly(ADP-ribose) polymerase) cleavage were both enhanced by quercetin.	Quercetin	112-121	TNF superfamily member 10	Homo sapiens	4-9
17031854-7	2007	The TRAIL-mediated activation of caspase, and PARP (poly(ADP-ribose) polymerase) cleavage were both enhanced by quercetin.	Quercetin	112-121	poly(ADP-ribose) polymerase 1	Homo sapiens	46-50
17031854-7	2007	The TRAIL-mediated activation of caspase, and PARP (poly(ADP-ribose) polymerase) cleavage were both enhanced by quercetin.	Quercetin	112-121	poly(ADP-ribose) polymerase 1	Homo sapiens	52-79
17031854-9	2007	However, quercetin promoted the dephosphorylation of Akt.	Quercetin	9-18	AKT serine/threonine kinase 1	Homo sapiens	53-56
17031854-10	2007	Quercetin-induced potent inhibition of Akt phosphorylation.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	39-42
17031854-11	2007	Taken together, the present studies suggest that quercetin enhances TRAIL-induced cytotoxicity by activating caspases and inhibiting phosphorylation of Akt.	Quercetin	49-58	TNF superfamily member 10	Homo sapiens	68-73
17031854-11	2007	Taken together, the present studies suggest that quercetin enhances TRAIL-induced cytotoxicity by activating caspases and inhibiting phosphorylation of Akt.	Quercetin	49-58	AKT serine/threonine kinase 1	Homo sapiens	152-155
17184768-0	2007	The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells.	Quercetin	31-40	prostaglandin-endoperoxide synthase 2	Homo sapiens	109-125
17184768-1	2007	We examined the ability of the flavonoids quercetin and kaempferol to modulate inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and reactive C-protein (CRP) expression, and to induce changes in the nuclear factor kappa B (NF-kappaB) pathway in the human hepatocyte-derived cell line Chang Liver.	Quercetin	42-51	nitric oxide synthase 2	Homo sapiens	112-116
17184768-1	2007	We examined the ability of the flavonoids quercetin and kaempferol to modulate inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and reactive C-protein (CRP) expression, and to induce changes in the nuclear factor kappa B (NF-kappaB) pathway in the human hepatocyte-derived cell line Chang Liver.	Quercetin	42-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	119-135
17332522-3	2007	Steroidogenic acute regulatory (StAR) mRNA expression and StAR promoter activity in transiently transfected MA-10 cells were significantly reduced by genistein or resveratrol, but increased by quercetin.	Quercetin	193-202	steroidogenic acute regulatory protein	Mus musculus	32-36
17332522-5	2007	Quercetin-induced increase in cAMP-stimulated progesterone secretion was reversed by ICI 182,780, an estrogen receptor (ER) antagonist.	Quercetin	0-9	estrogen receptor 1 (alpha)	Mus musculus	101-118
17332522-5	2007	Quercetin-induced increase in cAMP-stimulated progesterone secretion was reversed by ICI 182,780, an estrogen receptor (ER) antagonist.	Quercetin	0-9	estrogen receptor 1 (alpha)	Mus musculus	120-122
17332522-8	2007	We found that EGTA inhibited quercetin-plus cAMP-stimulated progesterone secretion and StAR promoter activity.	Quercetin	29-38	steroidogenic acute regulatory protein	Mus musculus	87-91
17476800-4	2007	Rank order of potency exhibited by the compounds in protecting G6PDH appeared as follows: hesperidin &gt; morin &gt; silibin &gt; naringin = quercetin &gt; kampferol &gt;&gt; astragalin.	Quercetin	141-150	glucose-6-phosphate dehydrogenase	Homo sapiens	63-68
17184768-1	2007	We examined the ability of the flavonoids quercetin and kaempferol to modulate inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and reactive C-protein (CRP) expression, and to induce changes in the nuclear factor kappa B (NF-kappaB) pathway in the human hepatocyte-derived cell line Chang Liver.	Quercetin	42-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	137-142
17184768-5	2007	Inhibitory effects by quercetin and kaempferol were also observed on NF-kappaB activation and on protein concentration of the phosphorylated form of the inhibitor IkappaB alpha and of IKK (IkappaB kinase)alpha.	Quercetin	22-31	nuclear factor kappa B subunit 1	Homo sapiens	69-78
17375204-5	2007	In contrast, treatment with quercetin, an HSP 70 inhibitor, inhibited both upregulation of endothelial HSP 70 and formation of SFs in response to tensile stress.	Quercetin	28-37	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	42-48
17184768-5	2007	Inhibitory effects by quercetin and kaempferol were also observed on NF-kappaB activation and on protein concentration of the phosphorylated form of the inhibitor IkappaB alpha and of IKK (IkappaB kinase)alpha.	Quercetin	22-31	NFKB inhibitor alpha	Homo sapiens	163-176
17184768-5	2007	Inhibitory effects by quercetin and kaempferol were also observed on NF-kappaB activation and on protein concentration of the phosphorylated form of the inhibitor IkappaB alpha and of IKK (IkappaB kinase)alpha.	Quercetin	22-31	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	189-209
17184768-6	2007	The present study suggests that the modulation of iNOS, COX-2 and CRP by quercetin or kaempferol may contribute to the anti-inflammatory effects of these two structurally similar flavonoids in Chang Liver cells, via mechanisms likely to involve blockade of NF-kappaB activation and the resultant up-regulation of the pro-inflammatory genes.	Quercetin	73-82	nitric oxide synthase 2	Homo sapiens	50-54
17184768-6	2007	The present study suggests that the modulation of iNOS, COX-2 and CRP by quercetin or kaempferol may contribute to the anti-inflammatory effects of these two structurally similar flavonoids in Chang Liver cells, via mechanisms likely to involve blockade of NF-kappaB activation and the resultant up-regulation of the pro-inflammatory genes.	Quercetin	73-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	56-61
17184768-6	2007	The present study suggests that the modulation of iNOS, COX-2 and CRP by quercetin or kaempferol may contribute to the anti-inflammatory effects of these two structurally similar flavonoids in Chang Liver cells, via mechanisms likely to involve blockade of NF-kappaB activation and the resultant up-regulation of the pro-inflammatory genes.	Quercetin	73-82	C-reactive protein	Homo sapiens	66-69
17184768-6	2007	The present study suggests that the modulation of iNOS, COX-2 and CRP by quercetin or kaempferol may contribute to the anti-inflammatory effects of these two structurally similar flavonoids in Chang Liver cells, via mechanisms likely to involve blockade of NF-kappaB activation and the resultant up-regulation of the pro-inflammatory genes.	Quercetin	73-82	nuclear factor kappa B subunit 1	Homo sapiens	257-266
17375204-5	2007	In contrast, treatment with quercetin, an HSP 70 inhibitor, inhibited both upregulation of endothelial HSP 70 and formation of SFs in response to tensile stress.	Quercetin	28-37	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	103-109
17191121-0	2007	NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells.	Quercetin	62-71	growth differentiation factor 15	Homo sapiens	0-5
17191121-3	2007	We found that quercetin induces the expression of NAG-1 (Non-steroidal anti-inflammatory drug activated gene-1), a TGF-beta superfamily protein, during quercetin-induced apoptosis of HCT116 human colon carcinoma cells.	Quercetin	152-161	growth differentiation factor 15	Homo sapiens	57-110
17191121-0	2007	NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells.	Quercetin	62-71	early growth response 1	Homo sapiens	32-37
17191121-4	2007	Reporter assays using the luciferase constructs containing NAG-1 promoter region demonstrate that early growth response-1 (EGR-1) and p53 are required for quercetin-mediated activation of the NAG-1 promoter.	Quercetin	155-164	growth differentiation factor 15	Homo sapiens	59-64
17191121-4	2007	Reporter assays using the luciferase constructs containing NAG-1 promoter region demonstrate that early growth response-1 (EGR-1) and p53 are required for quercetin-mediated activation of the NAG-1 promoter.	Quercetin	155-164	early growth response 1	Homo sapiens	98-121
17191121-0	2007	NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells.	Quercetin	62-71	tumor protein p53	Homo sapiens	42-45
17191121-4	2007	Reporter assays using the luciferase constructs containing NAG-1 promoter region demonstrate that early growth response-1 (EGR-1) and p53 are required for quercetin-mediated activation of the NAG-1 promoter.	Quercetin	155-164	early growth response 1	Homo sapiens	123-128
17191121-4	2007	Reporter assays using the luciferase constructs containing NAG-1 promoter region demonstrate that early growth response-1 (EGR-1) and p53 are required for quercetin-mediated activation of the NAG-1 promoter.	Quercetin	155-164	tumor protein p53	Homo sapiens	134-137
17191121-3	2007	We found that quercetin induces the expression of NAG-1 (Non-steroidal anti-inflammatory drug activated gene-1), a TGF-beta superfamily protein, during quercetin-induced apoptosis of HCT116 human colon carcinoma cells.	Quercetin	14-23	growth differentiation factor 15	Homo sapiens	50-55
17191121-4	2007	Reporter assays using the luciferase constructs containing NAG-1 promoter region demonstrate that early growth response-1 (EGR-1) and p53 are required for quercetin-mediated activation of the NAG-1 promoter.	Quercetin	155-164	growth differentiation factor 15	Homo sapiens	192-197
17191121-3	2007	We found that quercetin induces the expression of NAG-1 (Non-steroidal anti-inflammatory drug activated gene-1), a TGF-beta superfamily protein, during quercetin-induced apoptosis of HCT116 human colon carcinoma cells.	Quercetin	14-23	growth differentiation factor 15	Homo sapiens	57-110
17191121-5	2007	Overexpression of NAG-1 enhanced the apoptotic effect of quercetin, but suppression of quercetin-induced NAG-1 expression by NAG-1 siRNA attenuated quercetin-induced apoptosis in HCT116 cells.	Quercetin	57-66	growth differentiation factor 15	Homo sapiens	18-23
17191121-5	2007	Overexpression of NAG-1 enhanced the apoptotic effect of quercetin, but suppression of quercetin-induced NAG-1 expression by NAG-1 siRNA attenuated quercetin-induced apoptosis in HCT116 cells.	Quercetin	87-96	growth differentiation factor 15	Homo sapiens	105-110
17191121-3	2007	We found that quercetin induces the expression of NAG-1 (Non-steroidal anti-inflammatory drug activated gene-1), a TGF-beta superfamily protein, during quercetin-induced apoptosis of HCT116 human colon carcinoma cells.	Quercetin	152-161	growth differentiation factor 15	Homo sapiens	50-55
17191121-5	2007	Overexpression of NAG-1 enhanced the apoptotic effect of quercetin, but suppression of quercetin-induced NAG-1 expression by NAG-1 siRNA attenuated quercetin-induced apoptosis in HCT116 cells.	Quercetin	87-96	growth differentiation factor 15	Homo sapiens	105-110
17172639-3	2007	Robust inhibition of glucose and fructose transport by GLUT2 expressed in Xenopus laevis oocytes was produced by the flavonols myricetin, fisetin, the widely consumed flavonoid quercetin, and its glucoside precursor isoquercitrin [corrected].	Quercetin	177-186	solute carrier family 2 member 2 S homeolog	Xenopus laevis	55-60
17191121-5	2007	Overexpression of NAG-1 enhanced the apoptotic effect of quercetin, but suppression of quercetin-induced NAG-1 expression by NAG-1 siRNA attenuated quercetin-induced apoptosis in HCT116 cells.	Quercetin	87-96	growth differentiation factor 15	Homo sapiens	105-110
17191121-5	2007	Overexpression of NAG-1 enhanced the apoptotic effect of quercetin, but suppression of quercetin-induced NAG-1 expression by NAG-1 siRNA attenuated quercetin-induced apoptosis in HCT116 cells.	Quercetin	87-96	growth differentiation factor 15	Homo sapiens	105-110
17191121-6	2007	Taken together, the present study demonstrates for the first time that quercetin induces apoptosis via NAG-1, providing a mechanistic basis for the apoptotic effect of quercetin in colon carcinoma cells.	Quercetin	71-80	growth differentiation factor 15	Homo sapiens	103-108
17191121-6	2007	Taken together, the present study demonstrates for the first time that quercetin induces apoptosis via NAG-1, providing a mechanistic basis for the apoptotic effect of quercetin in colon carcinoma cells.	Quercetin	168-177	growth differentiation factor 15	Homo sapiens	103-108
17172639-6	2007	Sugar transport by GLUT2 overexpressed in pituitary cells and naturally present in Caco-2E intestinal cells was similarly inhibited by quercetin.	Quercetin	135-144	solute carrier family 2 member 2	Homo sapiens	19-24
17055466-0	2007	The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2.	Quercetin	22-31	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	42-46
17046132-4	2007	Using 1-chloro-2,4 dinitrobenzene (CDNB) as a substrate, ellagic acid and curcumin were shown to inhibit GSTs A1-1, A2-2, M1-1, M2-2 and P1-1 with IC(50) values ranging from 0.04 to 5 microM whilst genistein, kaempferol and quercetin inhibited GSTs M1-1 and M2-2 only.	Quercetin	224-233	glutathione S-transferase kappa 1	Homo sapiens	105-109
16969687-2	2007	Moreover, quercetin induced caspase-3 and cytochrome c-dependent apoptosis almost exclusively in the former cell line.	Quercetin	10-19	caspase 3	Homo sapiens	28-37
16969687-2	2007	Moreover, quercetin induced caspase-3 and cytochrome c-dependent apoptosis almost exclusively in the former cell line.	Quercetin	10-19	cytochrome c, somatic	Homo sapiens	42-54
17070561-10	2007	One possible mechanism of action of SHP extract may be related to quercetin in protecting neurons from oxidative damage.	Quercetin	66-75	nuclear receptor subfamily 0, group B, member 2	Rattus norvegicus	36-39
17362645-0	2007	[A study of the effects of quercetin on the expression of HMGCR and the cholesterol synthesis of HL-02 cells].	Quercetin	27-36	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	58-63
17234771-6	2007	Depletion of Hsp70 by quercetin decreased cell viability and induced apoptosis in cancer cells but not in normal pancreatic ductal cells.	Quercetin	22-31	heat shock protein family A (Hsp70) member 4	Homo sapiens	13-18
17234771-8	2007	Daily administration of quercetin to nude mice decreased tumor size as well as Hsp70 levels in tumor tissue.	Quercetin	24-33	heat shock protein 1B	Mus musculus	79-84
17055466-4	2007	We hypothesized that quercetin might activate BKCa channel in isolated myocytes from rat coronary arteries and that this mechanism might be involved in its coronary artery relaxant effects.	Quercetin	21-30	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	46-50
17055466-7	2007	RESULTS: Quercetin (&gt;0.1 muM) increased the outward currents in the whole range of test potentials, hyperpolarized cell membranes, and increased the frequency of spontaneous transient outward currents (STOCs) carried by BKCa channels.	Quercetin	9-18	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	223-227
17055466-12	2007	CONCLUSION: Quercetin increased BKCa currents via production of intracellular H(2)O(2).	Quercetin	12-21	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	32-36
16777995-0	2007	Genistein and quercetin increase connexin43 and suppress growth of breast cancer cells.	Quercetin	14-23	gap junction protein alpha 1	Homo sapiens	33-43
17045724-4	2007	Quercetin and its two O-methylated metabolites were able to reduce intracellular ROS production but only quercetin was able to counteract H(2)O(2) cell damage, as measured by MTT reduction assay, caspase-3 activity and DNA fragmentation assays.	Quercetin	0-9	caspase 3	Rattus norvegicus	196-205
17045724-4	2007	Quercetin and its two O-methylated metabolites were able to reduce intracellular ROS production but only quercetin was able to counteract H(2)O(2) cell damage, as measured by MTT reduction assay, caspase-3 activity and DNA fragmentation assays.	Quercetin	105-114	caspase 3	Rattus norvegicus	196-205
17045724-5	2007	Furthermore, only quercetin was observed to modulate pro-survival signalling through ERK1/2 and PI3K/Akt pathway.	Quercetin	18-27	mitogen activated protein kinase 3	Rattus norvegicus	85-91
17045724-5	2007	Furthermore, only quercetin was observed to modulate pro-survival signalling through ERK1/2 and PI3K/Akt pathway.	Quercetin	18-27	AKT serine/threonine kinase 1	Rattus norvegicus	101-104
17045724-6	2007	In conclusion we have demonstrated that quercetin, but not its O-methylated metabolites, exerts protective effects against H(2)O(2) cardiotoxicity and that the mechanism of its action involves the modulation of PI3K/Akt and ERK1/2 signalling pathways.	Quercetin	40-49	AKT serine/threonine kinase 1	Rattus norvegicus	216-219
17045724-6	2007	In conclusion we have demonstrated that quercetin, but not its O-methylated metabolites, exerts protective effects against H(2)O(2) cardiotoxicity and that the mechanism of its action involves the modulation of PI3K/Akt and ERK1/2 signalling pathways.	Quercetin	40-49	mitogen activated protein kinase 3	Rattus norvegicus	224-230
16777995-5	2007	The purpose of this study was to determine whether common flavonoids, genistein and quercetin, increase connexin43 (Cx43) levels, improve GJIC and suppress growth of a metastatic human breast tumor cell line (MDA-MB-231).	Quercetin	84-93	gap junction protein alpha 1	Homo sapiens	104-114
16777995-5	2007	The purpose of this study was to determine whether common flavonoids, genistein and quercetin, increase connexin43 (Cx43) levels, improve GJIC and suppress growth of a metastatic human breast tumor cell line (MDA-MB-231).	Quercetin	84-93	gap junction protein alpha 1	Homo sapiens	116-120
16777995-6	2007	Quercetin (2.5, 5 microg/ml) and genistein (0.5, 2.5, 15 microg/ml) upregulated Cx43 but failed to increase GJIC.	Quercetin	0-9	gap junction protein alpha 1	Homo sapiens	80-84
16777995-8	2007	In contrast, Cx43 aggregated in the perinuclear region following quercetin treatment (0.5, 2.5, 5, 15 microg/ml).	Quercetin	65-74	gap junction protein alpha 1	Homo sapiens	13-17
16777995-10	2007	In summary, genistein and quercetin increase Cx43 and suppress MDA-MB-231 cell proliferation at physiologically relevant concentrations.	Quercetin	26-35	gap junction protein alpha 1	Homo sapiens	45-49
17684411-7	2007	In this study, we report that quercetin-inhibited A549 lung carcinoma cell proliferation was associated with activation of the extracellular signal-regulated kinase (ERK).	Quercetin	30-39	mitogen-activated protein kinase 1	Homo sapiens	127-164
17684411-7	2007	In this study, we report that quercetin-inhibited A549 lung carcinoma cell proliferation was associated with activation of the extracellular signal-regulated kinase (ERK).	Quercetin	30-39	mitogen-activated protein kinase 1	Homo sapiens	166-169
17684411-8	2007	Inhibition of MEK1/2 but not PI3 kinase, p38 kinase or JNK abolished quercetin-induced apoptosis suggesting MEK-ERK activation was required to trigger apoptosis.	Quercetin	69-78	mitogen-activated protein kinase kinase 1	Homo sapiens	14-20
17684411-8	2007	Inhibition of MEK1/2 but not PI3 kinase, p38 kinase or JNK abolished quercetin-induced apoptosis suggesting MEK-ERK activation was required to trigger apoptosis.	Quercetin	69-78	mitogen-activated protein kinase kinase 7	Homo sapiens	14-17
17684411-8	2007	Inhibition of MEK1/2 but not PI3 kinase, p38 kinase or JNK abolished quercetin-induced apoptosis suggesting MEK-ERK activation was required to trigger apoptosis.	Quercetin	69-78	mitogen-activated protein kinase 1	Homo sapiens	112-115
18007607-5	2007	In the model of U937 cells incubated with the chemopreventive agent quercetin (3,3",4",5,7-pentahydroxyflavone), we describe the detection at the single cell level of changes in MMP (by JC-1), early apoptosis (exposition of phosphatidylserine on the plasma membrane detected by annexin-V), late apoptosis and secondary necrosis (decreased DNA content by Hoechst 33342 and permeability of the plasma membrane to propidium iodide).	Quercetin	68-77	annexin A5	Homo sapiens	278-287
18274639-0	2007	Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages.	Quercetin	64-73	signal transducer and activator of transcription 1	Homo sapiens	96-102
18274639-0	2007	Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages.	Quercetin	64-73	nitric oxide synthase 2	Homo sapiens	262-266
18274639-5	2007	Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS.	Quercetin	23-32	signal transducer and activator of transcription 1	Homo sapiens	84-134
18274639-5	2007	Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS.	Quercetin	23-32	signal transducer and activator of transcription 1	Homo sapiens	136-142
18274639-5	2007	Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS.	Quercetin	23-32	nitric oxide synthase 2	Homo sapiens	188-192
18007607-5	2007	In the model of U937 cells incubated with the chemopreventive agent quercetin (3,3",4",5,7-pentahydroxyflavone), we describe the detection at the single cell level of changes in MMP (by JC-1), early apoptosis (exposition of phosphatidylserine on the plasma membrane detected by annexin-V), late apoptosis and secondary necrosis (decreased DNA content by Hoechst 33342 and permeability of the plasma membrane to propidium iodide).	Quercetin	79-110	annexin A5	Homo sapiens	278-287
18001220-0	2007	Quercetin selectively inhibits bioreduction and enhances apoptosis in melanoma cells that overexpress tyrosinase.	Quercetin	0-9	tyrosinase	Homo sapiens	102-112
18001220-1	2007	Tyrosinase is expressed in melanoma cells and catalyzes the formation of 3,3",4",5,7-pentahydroxyflavone (quercetin) into reactive quinone species and subsequent glutathionyl adducts.	Quercetin	73-104	tyrosinase	Homo sapiens	0-10
18001220-1	2007	Tyrosinase is expressed in melanoma cells and catalyzes the formation of 3,3",4",5,7-pentahydroxyflavone (quercetin) into reactive quinone species and subsequent glutathionyl adducts.	Quercetin	106-115	tyrosinase	Homo sapiens	0-10
18001220-5	2007	The antioxidant/electrophile response element-induced enzymes, glutathione-S-transferase (GST), and nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1 were expressed at high levels in Tyr+ cells and contributed to pro-oxidant quercetin metabolism.	Quercetin	244-253	glutathione S-transferase kappa 1	Homo sapiens	63-88
18001220-5	2007	The antioxidant/electrophile response element-induced enzymes, glutathione-S-transferase (GST), and nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1 were expressed at high levels in Tyr+ cells and contributed to pro-oxidant quercetin metabolism.	Quercetin	244-253	glutathione S-transferase kappa 1	Homo sapiens	90-93
18001220-7	2007	The increase in apoptosis following quercetin exposure was p53/Bax mediated and correlated with a decrease in GST-driven bioreduction capacity and an increase in ROS.	Quercetin	36-45	tumor protein p53	Homo sapiens	59-62
18001220-7	2007	The increase in apoptosis following quercetin exposure was p53/Bax mediated and correlated with a decrease in GST-driven bioreduction capacity and an increase in ROS.	Quercetin	36-45	BCL2 associated X, apoptosis regulator	Homo sapiens	63-66
18001220-7	2007	The increase in apoptosis following quercetin exposure was p53/Bax mediated and correlated with a decrease in GST-driven bioreduction capacity and an increase in ROS.	Quercetin	36-45	glutathione S-transferase kappa 1	Homo sapiens	110-113
18001220-8	2007	In conclusion, quercetin can selectively sensitize Tyr+ expressing melanoma cells to apoptosis and may serve as an adjuvant to chemotherapy by enhancing cell death and interfering with GST-mediated drug resistance.	Quercetin	15-24	glutathione S-transferase kappa 1	Homo sapiens	185-188
17010942-6	2006	Tolbutamide oxidation by the marmoset liver microsomes and the recombinant P450 M-2C was inhibited most effectively by quercetin, a CYP2C8 inhibitor, followed by omeprazole, a CYP2C19 inhibitor, whereas sulfaphenazole, a CYP2C9 inhibitor, was less potent under the conditions used.	Quercetin	119-128	cytochrome P450 2C8	Callithrix jacchus	132-138
17592224-6	2007	In addition, it has been shown that natural phenolic compounds (e.g. quercetin, resveratrol) of alcoholic beverages exert different effects on the pancreasin vitro, such as inhibition of pancreatic enzyme output, of pancreatic stellate cell activation and of pancreatic cancer growth as well as protective effects against oxidative stress and on experimental induced acute pancreatitis in rats.	Quercetin	69-78	serine protease 27	Rattus norvegicus	147-157
17379280-3	2007	This study determined whether polyphenols (catechin and quercetin) activated kinase-signaling cascades that suppress PAI-1 expression and whether this suppression is at the transcription level in human coronary artery endothelial cells (ECs) remains unresolved.	Quercetin	56-65	serpin family E member 1	Homo sapiens	117-122
17379280-7	2007	Catechin and quercetin decreased EC PAI-1 mRNA in a time- and dose-dependent manner, reaching a maximum at 4 and 2 h, respectively.	Quercetin	13-22	serpin family E member 1	Homo sapiens	36-41
17177569-4	2006	AJE and quercetin acted as weak inducers of CYP1A1 mRNA and protein, and AJE, quercetin, and phlorizin led to a slight induction of CYP1A1-catalyzed 7-ethoxyresorufin O-deethylase (EROD) activity.	Quercetin	8-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	44-50
17177569-4	2006	AJE and quercetin acted as weak inducers of CYP1A1 mRNA and protein, and AJE, quercetin, and phlorizin led to a slight induction of CYP1A1-catalyzed 7-ethoxyresorufin O-deethylase (EROD) activity.	Quercetin	8-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138
17177569-4	2006	AJE and quercetin acted as weak inducers of CYP1A1 mRNA and protein, and AJE, quercetin, and phlorizin led to a slight induction of CYP1A1-catalyzed 7-ethoxyresorufin O-deethylase (EROD) activity.	Quercetin	78-87	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138
17177569-5	2006	However, AJE, quercetin, and phloretin were highly effective in suppressing CYP1A1 induction in co-incubations of the cells with 1 nM TCDD.	Quercetin	14-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	76-82
17177569-9	2006	AJE, quercetin, and phloretin also antagonized the TCDD-mediated induction of a reporter gene driven by a regulatory sequence of the human CYP1A1 gene promoter.	Quercetin	5-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	139-145
17006592-9	2007	The deletion changed the subsequent reading frame resulting in a truncated polypeptide consisting of 37 amino acids that lacked the dioxygenase domains A and B. Extracts of E. coli cells expressing gmfls1 of Harosoy catalyzed the formation of quercetin from dihydroquercetin, whereas cell extracts expressing gmfls1 of Harosoy-wm had no FLS activity.	Quercetin	243-252	flavonol synthase	Glycine max	198-204
17006592-9	2007	The deletion changed the subsequent reading frame resulting in a truncated polypeptide consisting of 37 amino acids that lacked the dioxygenase domains A and B. Extracts of E. coli cells expressing gmfls1 of Harosoy catalyzed the formation of quercetin from dihydroquercetin, whereas cell extracts expressing gmfls1 of Harosoy-wm had no FLS activity.	Quercetin	243-252	flavonol synthase	Glycine max	309-315
17006592-9	2007	The deletion changed the subsequent reading frame resulting in a truncated polypeptide consisting of 37 amino acids that lacked the dioxygenase domains A and B. Extracts of E. coli cells expressing gmfls1 of Harosoy catalyzed the formation of quercetin from dihydroquercetin, whereas cell extracts expressing gmfls1 of Harosoy-wm had no FLS activity.	Quercetin	243-252	flavonol synthase	Glycine max	337-340
16507316-4	2007	We showed earlier that two red wine phenolics, resveratrol and quercetin, suppressed TF induction in endothelial cells.	Quercetin	63-72	coagulation factor III, tissue factor	Homo sapiens	85-87
16507316-6	2007	We also tested possible synergistic effects of resveratrol and quercetin with the other major red wine phenolics in suppression of lipopolysaccharide-induced TF expression in human PBMCs.	Quercetin	63-72	coagulation factor III, tissue factor	Homo sapiens	158-160
16507316-10	2007	Among major red wine phenolics, quercetin appears to be the predominant suppressor of TF induction.	Quercetin	32-41	coagulation factor III, tissue factor	Homo sapiens	86-88
17010942-6	2006	Tolbutamide oxidation by the marmoset liver microsomes and the recombinant P450 M-2C was inhibited most effectively by quercetin, a CYP2C8 inhibitor, followed by omeprazole, a CYP2C19 inhibitor, whereas sulfaphenazole, a CYP2C9 inhibitor, was less potent under the conditions used.	Quercetin	119-128	cytochrome P450 2C19	Callithrix jacchus	176-183
17046822-4	2006	Inhibition of Hsp70 synthesis by an inhibitor (quercetin) or antisense hsp70 attenuated not only Hsp70 expression but also the anti-apoptotic capacity of CpG-B ODN.	Quercetin	47-56	heat shock protein 1B	Mus musculus	14-19
17010942-6	2006	Tolbutamide oxidation by the marmoset liver microsomes and the recombinant P450 M-2C was inhibited most effectively by quercetin, a CYP2C8 inhibitor, followed by omeprazole, a CYP2C19 inhibitor, whereas sulfaphenazole, a CYP2C9 inhibitor, was less potent under the conditions used.	Quercetin	119-128	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	221-227
17046822-5	2006	Ectopic expression of Hsp70 rescued the inhibitory effect of quercetin on CpG-B ODN-induced anti-apoptosis.	Quercetin	61-70	heat shock protein 1B	Mus musculus	22-27
17191106-4	2006	In this report we show that quercetin, a natural compound able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase and IL-6 and the down-regulation of histidine decarboxylase (HDC) mRNA from human mast cell (HMC)-1 cells.	Quercetin	28-37	interleukin 6	Homo sapiens	159-163
17046822-6	2006	Additional experiments demonstrated that quercetin and anti-sense hsp70 modulated CpG-B ODN-induced anti-apoptosis via a caspase-3-independent pathway by down-regulating the survival gene bcl-x(L) and by increasing translocation of apoptosis-inducing factor.	Quercetin	41-50	caspase 3	Mus musculus	121-130
17046822-6	2006	Additional experiments demonstrated that quercetin and anti-sense hsp70 modulated CpG-B ODN-induced anti-apoptosis via a caspase-3-independent pathway by down-regulating the survival gene bcl-x(L) and by increasing translocation of apoptosis-inducing factor.	Quercetin	41-50	BCL2-like 1	Mus musculus	188-196
17211565-9	2006	In addition, treatment with quercetin appears to reduce the osmotic stress induced by hyperglycaemia, as assessed by polyol pathway enzyme aldose reductase.	Quercetin	28-37	aldo-keto reductase family 1 member B1	Rattus norvegicus	139-155
16552572-5	2006	RESULTS: Tricin and quercetin inhibited enzyme activity in purified COX-1 and -2 preparations with IC50 values of near 1 (tricin) and 5 microM (quercetin).	Quercetin	20-29	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	68-80
16552572-5	2006	RESULTS: Tricin and quercetin inhibited enzyme activity in purified COX-1 and -2 preparations with IC50 values of near 1 (tricin) and 5 microM (quercetin).	Quercetin	144-153	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	68-80
17191106-4	2006	In this report we show that quercetin, a natural compound able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase and IL-6 and the down-regulation of histidine decarboxylase (HDC) mRNA from human mast cell (HMC)-1 cells.	Quercetin	28-37	histidine decarboxylase	Homo sapiens	191-214
17191106-4	2006	In this report we show that quercetin, a natural compound able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase and IL-6 and the down-regulation of histidine decarboxylase (HDC) mRNA from human mast cell (HMC)-1 cells.	Quercetin	28-37	histidine decarboxylase	Homo sapiens	216-219
17191106-5	2006	As quercetin dramatically inhibits mast cell tryptase and IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation.	Quercetin	3-12	interleukin 6	Homo sapiens	58-62
17191106-5	2006	As quercetin dramatically inhibits mast cell tryptase and IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation.	Quercetin	3-12	histidine decarboxylase	Homo sapiens	75-78
17191106-5	2006	As quercetin dramatically inhibits mast cell tryptase and IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation.	Quercetin	141-150	interleukin 6	Homo sapiens	58-62
17191106-5	2006	As quercetin dramatically inhibits mast cell tryptase and IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation.	Quercetin	141-150	histidine decarboxylase	Homo sapiens	75-78
17103373-5	2006	Quercetin and catechin could regulate S100B-activated oxidant stress-sensitive pathways through blocking p47phox protein expression.	Quercetin	0-9	S100 calcium binding protein B	Homo sapiens	38-43
17103373-5	2006	Quercetin and catechin could regulate S100B-activated oxidant stress-sensitive pathways through blocking p47phox protein expression.	Quercetin	0-9	pleckstrin	Homo sapiens	105-108
17103373-4	2006	S100B treatment with quercetin and catechin in THP-1 cells had inhibitory effects on the expression of pro-inflammatory genes and protein levels.	Quercetin	21-30	S100 calcium binding protein B	Homo sapiens	0-5
17103373-4	2006	S100B treatment with quercetin and catechin in THP-1 cells had inhibitory effects on the expression of pro-inflammatory genes and protein levels.	Quercetin	21-30	GLI family zinc finger 2	Homo sapiens	47-52
17103373-6	2006	Treatment with quercetin and catechin could eliminate reactive oxygen species (ROS) to reduce oxidative stress stimulated by S100B in THP-1 cells.	Quercetin	15-24	S100 calcium binding protein B	Homo sapiens	125-130
17103373-6	2006	Treatment with quercetin and catechin could eliminate reactive oxygen species (ROS) to reduce oxidative stress stimulated by S100B in THP-1 cells.	Quercetin	15-24	GLI family zinc finger 2	Homo sapiens	134-139
17103373-7	2006	Quercetin and catechin also showed different regulatory abilities on mitogen-activated protein kinase (MAPK) signaling pathways by inhibiting protein expression in S100B-stimulated inflammatory responses in THP-1 cells.	Quercetin	0-9	S100 calcium binding protein B	Homo sapiens	164-169
17103373-7	2006	Quercetin and catechin also showed different regulatory abilities on mitogen-activated protein kinase (MAPK) signaling pathways by inhibiting protein expression in S100B-stimulated inflammatory responses in THP-1 cells.	Quercetin	0-9	GLI family zinc finger 2	Homo sapiens	207-212
17108117-6	2006	The hydrogen peroxide-mediated activation of both Cav-1 (-244/-222) and Cav-1 (-124/-101) was prevented by the antioxidant quercetin.	Quercetin	123-132	caveolin 1	Homo sapiens	50-55
17159770-6	2006	Moreover, synthetic beta-naphthoflavone and naturally occurring chrysin, quercetin and diosmin induced CYP1A1 in both tissues.	Quercetin	73-82	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	103-109
16996034-7	2006	RT-PCR and real time PCR analysis showed that quercetin treatment induced an increase in the expression of osteopontin, BMP2, alkaline phosphatase and Runx2.	Quercetin	46-55	secreted phosphoprotein 1	Homo sapiens	107-118
16996034-7	2006	RT-PCR and real time PCR analysis showed that quercetin treatment induced an increase in the expression of osteopontin, BMP2, alkaline phosphatase and Runx2.	Quercetin	46-55	bone morphogenetic protein 2	Homo sapiens	120-124
16996034-7	2006	RT-PCR and real time PCR analysis showed that quercetin treatment induced an increase in the expression of osteopontin, BMP2, alkaline phosphatase and Runx2.	Quercetin	46-55	RUNX family transcription factor 2	Homo sapiens	151-156
17108117-6	2006	The hydrogen peroxide-mediated activation of both Cav-1 (-244/-222) and Cav-1 (-124/-101) was prevented by the antioxidant quercetin.	Quercetin	123-132	caveolin 1	Homo sapiens	72-77
16970932-9	2006	Quercetin significantly inhibited the DNA strand breaks and the increase in CYP1A2 protein induced by AC or beta-carotene in combination with BaP or by AC alone.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-82
17049622-6	2006	Additionally, quercetin, an inhibitor of HSP synthesis, inhibited the up-regulation of HSP40 and 70 expressions and developed DSS-induced colitis in MIF(-/-) mice.	Quercetin	14-23	DnaJ heat shock protein family (Hsp40) member B1	Mus musculus	87-92
17049622-6	2006	Additionally, quercetin, an inhibitor of HSP synthesis, inhibited the up-regulation of HSP40 and 70 expressions and developed DSS-induced colitis in MIF(-/-) mice.	Quercetin	14-23	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	149-152
16970932-11	2006	Quercetin increased the safety of high doses of beta-carotene, possibly through interaction with beta-carotene"s oxidative products or through inhibition of CYP1A2 expression.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	157-163
17039455-8	2006	Quercetin treatment of cells caused a significant time- and dose-dependent increase in the caspase-3 activity.	Quercetin	0-9	caspase 3	Homo sapiens	91-100
16794257-2	2006	We hypothesized that quercetin blocks airway epithelial cell chemokine expression via PI 3-kinase-dependent mechanisms.	Quercetin	21-30	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	86-90
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	Quercetin	18-27	tumor necrosis factor	Homo sapiens	80-89
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	Quercetin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	Quercetin	18-27	C-C motif chemokine ligand 2	Homo sapiens	107-147
16794257-3	2006	Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.	Quercetin	18-27	C-C motif chemokine ligand 2	Homo sapiens	161-165
16794257-4	2006	Quercetin also inhibited TNF-alpha-induced PI 3-kinase activity, Akt phosphorylation, intracellular H(2)O(2) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt-dependent pathway.	Quercetin	0-9	tumor necrosis factor	Mus musculus	25-34
16794257-4	2006	Quercetin also inhibited TNF-alpha-induced PI 3-kinase activity, Akt phosphorylation, intracellular H(2)O(2) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt-dependent pathway.	Quercetin	0-9	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	43-47
16794257-4	2006	Quercetin also inhibited TNF-alpha-induced PI 3-kinase activity, Akt phosphorylation, intracellular H(2)O(2) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt-dependent pathway.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	65-68
16794257-4	2006	Quercetin also inhibited TNF-alpha-induced PI 3-kinase activity, Akt phosphorylation, intracellular H(2)O(2) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt-dependent pathway.	Quercetin	0-9	chemokine (C-X-C motif) ligand 15	Mus musculus	148-152
16794257-4	2006	Quercetin also inhibited TNF-alpha-induced PI 3-kinase activity, Akt phosphorylation, intracellular H(2)O(2) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt-dependent pathway.	Quercetin	0-9	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	321-325
16794257-4	2006	Quercetin also inhibited TNF-alpha-induced PI 3-kinase activity, Akt phosphorylation, intracellular H(2)O(2) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt-dependent pathway.	Quercetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	333-336
16794257-4	2006	Quercetin also inhibited TNF-alpha-induced PI 3-kinase activity, Akt phosphorylation, intracellular H(2)O(2) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt-dependent pathway.	Quercetin	234-243	tumor necrosis factor	Mus musculus	25-34
16794257-5	2006	Quercetin also reduced TNF-alpha-induced chemokine secretion in the presence of the transcriptional inhibitor actinomycin D, while inducing phosphorylation of eukaryotic translation initiation factor (eIF)-2alpha, suggesting that quercetin attenuates chemokine expression by post-transcriptional as well as transcriptional mechanisms.	Quercetin	0-9	tumor necrosis factor	Mus musculus	23-32
16794257-5	2006	Quercetin also reduced TNF-alpha-induced chemokine secretion in the presence of the transcriptional inhibitor actinomycin D, while inducing phosphorylation of eukaryotic translation initiation factor (eIF)-2alpha, suggesting that quercetin attenuates chemokine expression by post-transcriptional as well as transcriptional mechanisms.	Quercetin	230-239	tumor necrosis factor	Mus musculus	23-32
16794257-8	2006	Quercetin significantly reduced lung MCP-1 and methacholine responsiveness.	Quercetin	0-9	chemokine (C-C motif) ligand 2	Mus musculus	37-42
17021270-8	2006	Inhibition of HSP-70 by quercetin almost completely reversed the functional protection that was provided by heat preconditioning.	Quercetin	24-33	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	14-20
17056790-0	2006	Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2).	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	66-71
17056790-0	2006	Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2).	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	103-106
17056790-0	2006	Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2).	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	111-114
17056790-4	2006	Incubation of HepG2 cells with quercetin for 18 h induced apoptosis by the activation of caspase-3 and -9, but not caspase-8.	Quercetin	31-40	caspase 3	Homo sapiens	89-105
17056790-6	2006	A sustained inhibition of the major survival signals, Akt and extracellular regulated kinase (ERK), also occurred in quercetin-treated cells.	Quercetin	117-126	AKT serine/threonine kinase 1	Homo sapiens	54-57
17056790-6	2006	A sustained inhibition of the major survival signals, Akt and extracellular regulated kinase (ERK), also occurred in quercetin-treated cells.	Quercetin	117-126	mitogen-activated protein kinase 1	Homo sapiens	62-92
17056790-6	2006	A sustained inhibition of the major survival signals, Akt and extracellular regulated kinase (ERK), also occurred in quercetin-treated cells.	Quercetin	117-126	mitogen-activated protein kinase 1	Homo sapiens	94-97
17039455-9	2006	Western analysis indicated that treatment of quercetin markedly down-regulated PARP and Bcl-2 proteins, and activated caspase-3, Bax, and Bak proteins.	Quercetin	45-54	collagen type XI alpha 2 chain	Homo sapiens	79-83
17039455-9	2006	Western analysis indicated that treatment of quercetin markedly down-regulated PARP and Bcl-2 proteins, and activated caspase-3, Bax, and Bak proteins.	Quercetin	45-54	BCL2 apoptosis regulator	Homo sapiens	88-93
17039455-9	2006	Western analysis indicated that treatment of quercetin markedly down-regulated PARP and Bcl-2 proteins, and activated caspase-3, Bax, and Bak proteins.	Quercetin	45-54	caspase 3	Homo sapiens	118-127
17039455-9	2006	Western analysis indicated that treatment of quercetin markedly down-regulated PARP and Bcl-2 proteins, and activated caspase-3, Bax, and Bak proteins.	Quercetin	45-54	BCL2 associated X, apoptosis regulator	Homo sapiens	129-132
17039455-9	2006	Western analysis indicated that treatment of quercetin markedly down-regulated PARP and Bcl-2 proteins, and activated caspase-3, Bax, and Bak proteins.	Quercetin	45-54	BCL2 antagonist/killer 1	Homo sapiens	138-141
16934226-7	2006	We also found that luteolin and quercetin are able to stimulate the expression of the anti-inflammatory cytokine IL-10 at low concentrations (&lt;50microM).	Quercetin	32-41	interleukin 10	Mus musculus	113-118
16690199-3	2006	Docking analysis indicated that quercetin"s inhibitory behavior could be related to its planar structure and low steric hindrance, and to its ability to form a critical H-bond with thrombin His57.	Quercetin	32-41	coagulation factor II, thrombin	Homo sapiens	181-189
17036391-7	2006	Quercetin inhibited the up-regulation of HSP27 and HSP72 by polaprezinc and diminished the protective effect of polaprezinc against H(2)O(2)-caused injury in the cells.	Quercetin	0-9	heat shock protein family B (small) member 1	Homo sapiens	41-46
17036391-7	2006	Quercetin inhibited the up-regulation of HSP27 and HSP72 by polaprezinc and diminished the protective effect of polaprezinc against H(2)O(2)-caused injury in the cells.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1A	Homo sapiens	51-56
16968061-9	2006	The free aglycon phloretin as well as the flavonol quercetin effectively inhibited isolated GSK3beta, but did not affect the respective kinase activity within HT29 cells.	Quercetin	51-60	glycogen synthase kinase 3 beta	Homo sapiens	92-100
16922812-6	2006	For CYP2C19, the IC(50) values were 46, 46 and 62 micromol/L for ginsenoside Rd, quercetin and ginsenoside Rb2, respectively, whereas only ginsenoside Rd had an IC(50) value of 57 micromol/L for CYP2D6.	Quercetin	81-90	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	4-11
16720314-7	2006	In all cell lines, quercetin decreased the expression of mutant P53 and Survivin proteins.	Quercetin	19-28	tumor protein p53	Homo sapiens	64-67
16738032-5	2006	In the present study, three common flavonoids, quercetin, luteolin, and kaempferol, were used as substrates for glucuronidation by wild-type and variant UGT1A3s.	Quercetin	47-56	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	153-159
16738032-7	2006	In contrast, UGT1A3.4 exhibited an increase in glucuronidation efficiency of approximately 4 times and a clear preference to quercetin 7- and 3-hydroxyl groups.	Quercetin	125-134	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	13-19
16738032-9	2006	UGT1A3 variants have an altered glucuronidation activity toward quercetin, luteolin, and kaempferol and may alter human susceptibility to flavonoid exposure.	Quercetin	64-73	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	0-6
16762476-6	2006	The apiaceous constituents psoralen, 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and apigenin were potent inhibitors of hCYP1A2-mediated MROD activity in yeast microsomes, whereas quercetin was a modest hCYP1A2 inhibitor.	Quercetin	190-199	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	130-137
16720314-9	2006	Moreover, the DNA methylation levels of the estrogen receptor (Er-beta), P16INK4a and RASSF1A were strongly decreased (from 35 to 70%) in the quercetin-treated group compared to the control.	Quercetin	142-151	estrogen receptor 1	Homo sapiens	44-61
16762474-1	2006	Quercetin was reported to modulate CYP isoenzymes and P-glycoprotein (Pgp), a drug efflux transporter.	Quercetin	0-9	phosphoglycolate phosphatase	Rattus norvegicus	70-73
16720314-9	2006	Moreover, the DNA methylation levels of the estrogen receptor (Er-beta), P16INK4a and RASSF1A were strongly decreased (from 35 to 70%) in the quercetin-treated group compared to the control.	Quercetin	142-151	estrogen receptor 2	Homo sapiens	63-70
16762474-2	2006	Our previous study reported that quercetin significantly decreased the bioavailability of cyclosporin, a substrate for CYP3A4 and Pgp, in rats and pigs.	Quercetin	33-42	phosphoglycolate phosphatase	Rattus norvegicus	130-133
16720314-9	2006	Moreover, the DNA methylation levels of the estrogen receptor (Er-beta), P16INK4a and RASSF1A were strongly decreased (from 35 to 70%) in the quercetin-treated group compared to the control.	Quercetin	142-151	cyclin dependent kinase inhibitor 2A	Homo sapiens	73-81
16720314-9	2006	Moreover, the DNA methylation levels of the estrogen receptor (Er-beta), P16INK4a and RASSF1A were strongly decreased (from 35 to 70%) in the quercetin-treated group compared to the control.	Quercetin	142-151	Ras association domain family member 1	Homo sapiens	86-93
16720314-11	2006	Quercetin-induced apoptosis might be associated with a decrease in mutant P53 and Survivin proteins.	Quercetin	0-9	tumor protein p53	Homo sapiens	74-77
17112044-0	2006	[Interaction of quercetin and bovine serum albumin].	Quercetin	16-25	albumin	Homo sapiens	37-50
17112044-1	2006	The interaction of quercetin and bovine serum albumin (BSA) was investigated using fluorescence spectroscopy (FS) and ultraviolet spectroscopy (UV).	Quercetin	19-28	albumin	Homo sapiens	40-53
16806698-2	2006	Quercetin is also reported to have an inhibitory effect against matrix metalloproteinases (MMPs).	Quercetin	0-9	matrix metallopeptidase 9	Mus musculus	91-95
16806698-3	2006	Because MMPs are known to play a main role in the pathophysiology of brain ischemic insult, their mechanisms of possible protective effect of quercetin against brain ischemia remain to be clarified.	Quercetin	142-151	matrix metallopeptidase 9	Mus musculus	8-12
16806698-11	2006	Mice treated with quercetin showed attenuated brain MMP-9 activity.	Quercetin	18-27	matrix metallopeptidase 9	Mus musculus	52-57
16806698-13	2006	Quercetin significantly inhibited ischemia-induced elevation of MMP-9.	Quercetin	0-9	matrix metallopeptidase 9	Mus musculus	64-69
16806698-15	2006	Quercetin also inhibited TdT-mediated dUTP nick end labeling (TUNEL) staining in CA1 and CA2 areas.	Quercetin	0-9	deoxynucleotidyltransferase, terminal	Mus musculus	25-28
16806698-15	2006	Quercetin also inhibited TdT-mediated dUTP nick end labeling (TUNEL) staining in CA1 and CA2 areas.	Quercetin	0-9	carbonic anhydrase 1	Mus musculus	81-84
16806698-15	2006	Quercetin also inhibited TdT-mediated dUTP nick end labeling (TUNEL) staining in CA1 and CA2 areas.	Quercetin	0-9	carbonic anhydrase 2	Mus musculus	89-92
16806698-16	2006	These results demonstrate that quercetin, a natural flavonoid reduces global ischemia-induced neuronal damage through inhibition of MMP-9 activity.	Quercetin	31-40	matrix metallopeptidase 9	Mus musculus	132-137
17111826-0	2006	[The roles of c-Jun and CBP in the inhibitory effect of quercetin on prostate cancer cells].	Quercetin	56-65	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
16948901-6	2006	Expression of P53 and C-myc protein decreased following quercetin induction in a dose-dependent manner, whereas P16 expression increased significantly compared with that of the control group (P&lt;0.01).	Quercetin	56-65	tumor protein p53	Homo sapiens	14-17
16948901-6	2006	Expression of P53 and C-myc protein decreased following quercetin induction in a dose-dependent manner, whereas P16 expression increased significantly compared with that of the control group (P&lt;0.01).	Quercetin	56-65	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-27
16945047-1	2006	STUDY OBJECTIVES: To determine if quercetin, a bioflavonoid that inhibits p-glycoprotein, alters plasma saquinavir concentrations, and to explore the potential influence on intracellular concentrations.	Quercetin	34-43	ATP binding cassette subfamily B member 1	Homo sapiens	74-88
17111826-8	2006	CONCLUSION: Overexpression of c-Jun induced by quercetin had inhibitory effect on the function of AR protein, and increased CBP expression did not reverse the inhibition by quercetin.	Quercetin	47-56	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
17111826-0	2006	[The roles of c-Jun and CBP in the inhibitory effect of quercetin on prostate cancer cells].	Quercetin	56-65	CREB binding protein	Homo sapiens	24-27
17111826-8	2006	CONCLUSION: Overexpression of c-Jun induced by quercetin had inhibitory effect on the function of AR protein, and increased CBP expression did not reverse the inhibition by quercetin.	Quercetin	47-56	androgen receptor	Homo sapiens	98-100
17111826-2	2006	METHODS: The cell extracts treated with quercetin or without treatment were used for checking protein expression levels of c-Jun and cAMP response element binding protein (CREB)-binding protein (CBP) by Western blotting assay.	Quercetin	40-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-128
17111826-9	2006	Together, quercetin-mediated inhibition on the AR function might be not by competition with limited amount of CBP in the cell, but through a direct association of c-Jun and the AR.	Quercetin	10-19	androgen receptor	Homo sapiens	47-49
17111826-9	2006	Together, quercetin-mediated inhibition on the AR function might be not by competition with limited amount of CBP in the cell, but through a direct association of c-Jun and the AR.	Quercetin	10-19	CREB binding protein	Homo sapiens	110-113
17111826-2	2006	METHODS: The cell extracts treated with quercetin or without treatment were used for checking protein expression levels of c-Jun and cAMP response element binding protein (CREB)-binding protein (CBP) by Western blotting assay.	Quercetin	40-49	CREB binding protein	Homo sapiens	172-193
17111826-9	2006	Together, quercetin-mediated inhibition on the AR function might be not by competition with limited amount of CBP in the cell, but through a direct association of c-Jun and the AR.	Quercetin	10-19	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	163-168
17111826-9	2006	Together, quercetin-mediated inhibition on the AR function might be not by competition with limited amount of CBP in the cell, but through a direct association of c-Jun and the AR.	Quercetin	10-19	androgen receptor	Homo sapiens	177-179
17111826-2	2006	METHODS: The cell extracts treated with quercetin or without treatment were used for checking protein expression levels of c-Jun and cAMP response element binding protein (CREB)-binding protein (CBP) by Western blotting assay.	Quercetin	40-49	CREB binding protein	Homo sapiens	195-198
17111826-5	2006	RESULTS: Quercetin dramatically induced the protein expression of c-Jun which in turn inhibited the AR function.	Quercetin	9-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-71
17111826-5	2006	RESULTS: Quercetin dramatically induced the protein expression of c-Jun which in turn inhibited the AR function.	Quercetin	9-18	androgen receptor	Homo sapiens	100-102
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	Quercetin	114-123	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16274926-4	2006	In contrast, the level of the cyclin D, cyclin E, E2F1, and E2F2 was marked decreased in quercetin-treated U937 cells.	Quercetin	89-98	E2F transcription factor 1	Homo sapiens	50-54
16274926-4	2006	In contrast, the level of the cyclin D, cyclin E, E2F1, and E2F2 was marked decreased in quercetin-treated U937 cells.	Quercetin	89-98	E2F transcription factor 2	Homo sapiens	60-64
16274926-6	2006	In addition, quercetin-treated U937 cells showed DNA fragmentation, increased sub-G1 population, and generated a 60kDa cleavage product of PLC-gamma1 in a dose-dependent manner, which were significantly inhibited by z-VAD-fmk.	Quercetin	13-22	phospholipase C gamma 1	Homo sapiens	139-149
16707173-9	2006	We found that quercetin dramatically elevated the GAP43 mRNA expression in the brain of D-gal-treated mice to regenerate normal function of neurons against the cellular injury caused by D-gal.	Quercetin	14-23	growth associated protein 43	Mus musculus	50-55
16964758-4	2006	The maximum AP-1 luciferase induction of about 3 fold over control was observed with 20 microM concentrations of quercetin, chrysin and genistein and 50 microM concentration of kaempferol.	Quercetin	113-122	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	12-16
17044640-1	2006	OBJECTIVE: In order to investigate the pharmacological properties of Ginkgo biloba extract (GBE) on improving blood circulation, the regulating action of GBE and quercetin (a main flavonoid ingredient in GBE) on thrombomodulin (TM) expression and tissue-type plasminogen activator (t-PA) secretion was studied.	Quercetin	162-171	plasminogen activator, tissue type	Homo sapiens	282-286
17044640-4	2006	Both GBE and quercetin increased the t-PA release significantly.	Quercetin	13-22	plasminogen activator, tissue type	Homo sapiens	37-41
17044640-5	2006	CONCLUSION: The effect of GBE on improving blood circulation may be partly attributed to its promoting TM expression and t-PA secretion by endothelial cells, and quercetin participated in the effect of GBE on t-PA secretion.	Quercetin	162-171	plasminogen activator, tissue type	Homo sapiens	209-213
16239064-0	2006	Selenium- or quercetin-induced retardation of DNA synthesis in primary prostate cells occurs in the presence of a concomitant reduction in androgen-receptor activity.	Quercetin	13-22	androgen receptor	Homo sapiens	139-156
16239064-9	2006	In LNCaP cells transfected with an androgen-receptor (AR)-reporter gene coupled to luciferase, selenomethionine or quercetin reduced AR activity.	Quercetin	115-124	androgen receptor	Homo sapiens	35-52
16239064-9	2006	In LNCaP cells transfected with an androgen-receptor (AR)-reporter gene coupled to luciferase, selenomethionine or quercetin reduced AR activity.	Quercetin	115-124	androgen receptor	Homo sapiens	54-56
16846595-4	2006	Serum levels of carcino embryonic antigen (CEA), a potent marker for tumor growth and invasion was significantly decreased on quercetin treatment.	Quercetin	126-135	CEA cell adhesion molecule 20	Rattus norvegicus	16-41
16846595-4	2006	Serum levels of carcino embryonic antigen (CEA), a potent marker for tumor growth and invasion was significantly decreased on quercetin treatment.	Quercetin	126-135	CEA cell adhesion molecule 20	Rattus norvegicus	43-46
16846595-5	2006	Quercetin caused a significant decrease in the activities of acid phosphatase and Cathepsin D in serum of experimental animals.	Quercetin	0-9	cathepsin D	Rattus norvegicus	82-93
16846595-10	2006	Administration of quercetin caused a significant decrease of both t-PA and u-PA.	Quercetin	18-27	plasminogen activator, tissue type	Rattus norvegicus	66-70
16846595-10	2006	Administration of quercetin caused a significant decrease of both t-PA and u-PA.	Quercetin	18-27	plasminogen activator, urokinase	Rattus norvegicus	75-79
16777073-0	2006	The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells.	Quercetin	14-23	mitogen-activated protein kinase 8	Rattus norvegicus	55-58
16777073-10	2006	Quercetin reduced JNK phosphorylation but had no consistent effect on ERK phosphorylation.	Quercetin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	18-21
16455785-0	2006	Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.	Quercetin	86-95	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	8-24
16455785-1	2006	Using mice deficient in hepatic cytochrome P-450 oxidoreductase (POR), which disables the liver cytochrome P-450 system, we examined the metabolism and biological response of the anticarcinogenic flavonoid, quercetin.	Quercetin	207-216	cytochrome p450 oxidoreductase	Mus musculus	43-63
16455785-1	2006	Using mice deficient in hepatic cytochrome P-450 oxidoreductase (POR), which disables the liver cytochrome P-450 system, we examined the metabolism and biological response of the anticarcinogenic flavonoid, quercetin.	Quercetin	207-216	cytochrome p450 oxidoreductase	Mus musculus	65-68
16455785-1	2006	Using mice deficient in hepatic cytochrome P-450 oxidoreductase (POR), which disables the liver cytochrome P-450 system, we examined the metabolism and biological response of the anticarcinogenic flavonoid, quercetin.	Quercetin	207-216	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	32-48
16455785-7	2006	This demonstrates that the quercetin-mediated regulation of these biological functions in extrahepatic tissues is dependent on the functionality of the liver POR.	Quercetin	27-36	cytochrome p450 oxidoreductase	Mus musculus	158-161
16640504-3	2006	In the present study, whole genome DNA microarrays were used to evaluate the effect of quercetin on gene expression in the CO115 colon-adenocarcinoma cell line with the completely deleted chromosome 18 harbouring the SMAD4 tumour-suppressor gene related to colon carcinogenesis.	Quercetin	87-96	SMAD family member 4	Homo sapiens	217-222
16815818-3	2006	Green tea polyphenol, epigallocatechin gallate, quercetin, and rutin can reduce the co-oxidation reaction speed of tested compounds mediated by soybean lipoxygenase and the production of oxidative products and free radical intermediates.	Quercetin	48-57	linoleate 9S-lipoxygenase-4	Glycine max	152-164
16645725-8	2006	RESULTS: The results showed that quercetin treatment decreased the expressions of MMP-2 and MMP-9 in dose-dependent manner.	Quercetin	33-42	matrix metallopeptidase 2	Homo sapiens	82-87
16603228-6	2006	Using metabolically active HT29 cells we were able to show that quercetin (a stimulator of recombinant SIRT1) could not stimulate intracellular SIRT1.	Quercetin	64-73	sirtuin 1	Homo sapiens	103-108
16603228-7	2006	The major quercetin metabolite in humans, quercetin 3-O-glucuronide, slightly inhibited the recombinant SIRT1 activity which explains the lack of stimulatory action of quercetin in HT29 cells.	Quercetin	10-19	sirtuin 1	Homo sapiens	104-109
16603228-7	2006	The major quercetin metabolite in humans, quercetin 3-O-glucuronide, slightly inhibited the recombinant SIRT1 activity which explains the lack of stimulatory action of quercetin in HT29 cells.	Quercetin	42-51	sirtuin 1	Homo sapiens	104-109
16645725-5	2006	DESIGN AND METHODS: PC-3 cells were treated with quercetin at various concentrations (50 and 100 microM), for 24 h period and then subjected to western blot analysis to investigate the impact of quercetin on matrix metalloproteinase-2 (MMP-2) and 9 (MMP-9) expressions.	Quercetin	195-204	matrix metallopeptidase 2	Homo sapiens	208-234
16645725-8	2006	RESULTS: The results showed that quercetin treatment decreased the expressions of MMP-2 and MMP-9 in dose-dependent manner.	Quercetin	33-42	matrix metallopeptidase 9	Homo sapiens	92-97
16645725-6	2006	Conditioned medium and cell lysate of quercetin-treated PC-3 cells were subjected to western blot analysis for proteins expression of MMP-2 and MMP-9.	Quercetin	38-47	matrix metallopeptidase 2	Homo sapiens	134-139
16645725-9	2006	The level of pro-MMP-9 was found to be high in the 100 microM quercetin-treated cell lysate of PC-3 cells, suggesting inhibitory role of quercetin on pro-MMP-9 activation.	Quercetin	62-71	matrix metallopeptidase 9	Homo sapiens	17-22
16645725-6	2006	Conditioned medium and cell lysate of quercetin-treated PC-3 cells were subjected to western blot analysis for proteins expression of MMP-2 and MMP-9.	Quercetin	38-47	matrix metallopeptidase 9	Homo sapiens	144-149
16645725-9	2006	The level of pro-MMP-9 was found to be high in the 100 microM quercetin-treated cell lysate of PC-3 cells, suggesting inhibitory role of quercetin on pro-MMP-9 activation.	Quercetin	62-71	matrix metallopeptidase 9	Homo sapiens	154-159
16645725-9	2006	The level of pro-MMP-9 was found to be high in the 100 microM quercetin-treated cell lysate of PC-3 cells, suggesting inhibitory role of quercetin on pro-MMP-9 activation.	Quercetin	137-146	matrix metallopeptidase 9	Homo sapiens	17-22
16645725-9	2006	The level of pro-MMP-9 was found to be high in the 100 microM quercetin-treated cell lysate of PC-3 cells, suggesting inhibitory role of quercetin on pro-MMP-9 activation.	Quercetin	137-146	matrix metallopeptidase 9	Homo sapiens	154-159
16645725-10	2006	Gelatin zymography study also showed the decreased activities of MMP-2 and MMP-9 in quercetin treated cells.	Quercetin	84-93	matrix metallopeptidase 2	Homo sapiens	65-70
16645725-10	2006	Gelatin zymography study also showed the decreased activities of MMP-2 and MMP-9 in quercetin treated cells.	Quercetin	84-93	matrix metallopeptidase 9	Homo sapiens	75-80
16645725-11	2006	CONCLUSION: Hence, we speculated that inhibition of metastasis-specific MMPs in cancer cells may be one of the targets for anticancer function of quercetin, and thus provides the molecular basis for the development of quercetin as a novel chemopreventive agent for metastatic prostate cancer.	Quercetin	146-155	matrix metallopeptidase 2	Homo sapiens	72-76
16645725-11	2006	CONCLUSION: Hence, we speculated that inhibition of metastasis-specific MMPs in cancer cells may be one of the targets for anticancer function of quercetin, and thus provides the molecular basis for the development of quercetin as a novel chemopreventive agent for metastatic prostate cancer.	Quercetin	218-227	matrix metallopeptidase 2	Homo sapiens	72-76
16456646-11	2006	Transgenic tobacco plants harboring AmPAL1 under the control of the CaMV35S promoter showed significantly increased PAL activity and correlatively increased quercetin content than those in non-transformed plants.	Quercetin	157-166	phenylalanine ammonia-lyase	Nicotiana tabacum	38-41
17059008-0	2006	[Effects of quercetin on angiotensin II induced interleukin-6 in vascular smooth muscle cells].	Quercetin	12-21	angiotensinogen	Rattus norvegicus	25-39
17236628-4	2006	Both resveratrol and quercetin induced apoptosis in Namalwa cells as demonstrated by the increased number of hypodiploid cells, elevated level of mobile lipid domains and caspase-3 activation.	Quercetin	21-30	caspase 3	Homo sapiens	171-180
17059008-0	2006	[Effects of quercetin on angiotensin II induced interleukin-6 in vascular smooth muscle cells].	Quercetin	12-21	interleukin 6	Rattus norvegicus	48-61
17059008-3	2006	The production of IL-6 in supernatant of quercetin treated cultures was detected by ELISA.	Quercetin	41-50	interleukin 6	Rattus norvegicus	18-22
17059008-6	2006	Quercetin inhibited the production of Ang II -induced IL-6 in the culture in a dose-dependent manner.	Quercetin	0-9	angiotensinogen	Rattus norvegicus	38-44
17059008-1	2006	OBJECTIVE: To observe the effects of quercetin on angiotensin (Ang II) induced interleukin-6 (IL-6) in vascular smooth muscle cells (VSMCs).	Quercetin	37-46	angiotensinogen	Rattus norvegicus	50-61
17059008-6	2006	Quercetin inhibited the production of Ang II -induced IL-6 in the culture in a dose-dependent manner.	Quercetin	0-9	interleukin 6	Rattus norvegicus	54-58
17059008-7	2006	Similarly, the result with RT-PCR indicated that the expression of IL-6 mRNA induced by Ang II for 24h was down-regulated by quercetin.	Quercetin	125-134	interleukin 6	Rattus norvegicus	67-71
17059008-1	2006	OBJECTIVE: To observe the effects of quercetin on angiotensin (Ang II) induced interleukin-6 (IL-6) in vascular smooth muscle cells (VSMCs).	Quercetin	37-46	angiotensinogen	Rattus norvegicus	63-69
17059008-7	2006	Similarly, the result with RT-PCR indicated that the expression of IL-6 mRNA induced by Ang II for 24h was down-regulated by quercetin.	Quercetin	125-134	angiotensinogen	Rattus norvegicus	88-94
17059008-1	2006	OBJECTIVE: To observe the effects of quercetin on angiotensin (Ang II) induced interleukin-6 (IL-6) in vascular smooth muscle cells (VSMCs).	Quercetin	37-46	interleukin 6	Rattus norvegicus	79-92
17059008-8	2006	CONCLUSION: It demonstrates that quercetin possesses a inhibition of Ang II-induced production of IL-6 in VSMCs.	Quercetin	33-42	angiotensinogen	Rattus norvegicus	69-75
17059008-8	2006	CONCLUSION: It demonstrates that quercetin possesses a inhibition of Ang II-induced production of IL-6 in VSMCs.	Quercetin	33-42	interleukin 6	Rattus norvegicus	98-102
17059008-1	2006	OBJECTIVE: To observe the effects of quercetin on angiotensin (Ang II) induced interleukin-6 (IL-6) in vascular smooth muscle cells (VSMCs).	Quercetin	37-46	interleukin 6	Rattus norvegicus	94-98
17059008-9	2006	Moreover, quercetin also down regulates the expression of IL-6 mRNA, suggesting the action of quercetin on IL-6 release induced by Ang II in VSMCs may underlie its anti-inflammatory properties.	Quercetin	10-19	interleukin 6	Rattus norvegicus	58-62
16794327-5	2006	HPLC analysis of the reaction products indicated that AtGT-2 transfers a glucose molecule into several different kinds of flavonoids, eriodictyol being the most effective substrate, followed by luteolin, kaempferol, and quercetin.	Quercetin	220-229	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	54-60
17059008-9	2006	Moreover, quercetin also down regulates the expression of IL-6 mRNA, suggesting the action of quercetin on IL-6 release induced by Ang II in VSMCs may underlie its anti-inflammatory properties.	Quercetin	10-19	interleukin 6	Rattus norvegicus	107-111
17059008-9	2006	Moreover, quercetin also down regulates the expression of IL-6 mRNA, suggesting the action of quercetin on IL-6 release induced by Ang II in VSMCs may underlie its anti-inflammatory properties.	Quercetin	10-19	angiotensinogen	Rattus norvegicus	131-137
17059008-9	2006	Moreover, quercetin also down regulates the expression of IL-6 mRNA, suggesting the action of quercetin on IL-6 release induced by Ang II in VSMCs may underlie its anti-inflammatory properties.	Quercetin	94-103	interleukin 6	Rattus norvegicus	58-62
17059008-9	2006	Moreover, quercetin also down regulates the expression of IL-6 mRNA, suggesting the action of quercetin on IL-6 release induced by Ang II in VSMCs may underlie its anti-inflammatory properties.	Quercetin	94-103	interleukin 6	Rattus norvegicus	107-111
17059008-9	2006	Moreover, quercetin also down regulates the expression of IL-6 mRNA, suggesting the action of quercetin on IL-6 release induced by Ang II in VSMCs may underlie its anti-inflammatory properties.	Quercetin	94-103	angiotensinogen	Rattus norvegicus	131-137
16455111-7	2006	The apoptosis in SW 872 human liposarcoma cells induced by quercetin was mediated through the activation of caspase-3, Bax, and Bak and then cleavage of PARP and downregulation of Bcl-2.	Quercetin	59-68	caspase 3	Homo sapiens	108-117
16455111-7	2006	The apoptosis in SW 872 human liposarcoma cells induced by quercetin was mediated through the activation of caspase-3, Bax, and Bak and then cleavage of PARP and downregulation of Bcl-2.	Quercetin	59-68	BCL2 associated X, apoptosis regulator	Homo sapiens	119-122
16455111-7	2006	The apoptosis in SW 872 human liposarcoma cells induced by quercetin was mediated through the activation of caspase-3, Bax, and Bak and then cleavage of PARP and downregulation of Bcl-2.	Quercetin	59-68	BCL2 antagonist/killer 1	Homo sapiens	128-131
16455111-7	2006	The apoptosis in SW 872 human liposarcoma cells induced by quercetin was mediated through the activation of caspase-3, Bax, and Bak and then cleavage of PARP and downregulation of Bcl-2.	Quercetin	59-68	collagen type XI alpha 2 chain	Homo sapiens	153-157
16455111-7	2006	The apoptosis in SW 872 human liposarcoma cells induced by quercetin was mediated through the activation of caspase-3, Bax, and Bak and then cleavage of PARP and downregulation of Bcl-2.	Quercetin	59-68	BCL2 apoptosis regulator	Homo sapiens	180-185
16480901-3	2006	In some experiments, cells were also treated with quercetin (Que), a heat shock protein 70 (HSP70) inhibitor.	Quercetin	50-59	LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like	Oryctolagus cuniculus	69-90
16770007-8	2006	Treatment of platelets with quercetin and catechin resulted in an increase of NO and also down-regulated the expression of GpIIb/IIIa glycoprotein.	Quercetin	28-37	integrin subunit alpha 2b	Homo sapiens	123-128
16480901-3	2006	In some experiments, cells were also treated with quercetin (Que), a heat shock protein 70 (HSP70) inhibitor.	Quercetin	50-59	LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like	Oryctolagus cuniculus	92-97
16480901-3	2006	In some experiments, cells were also treated with quercetin (Que), a heat shock protein 70 (HSP70) inhibitor.	Quercetin	61-64	LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like	Oryctolagus cuniculus	69-90
16480901-3	2006	In some experiments, cells were also treated with quercetin (Que), a heat shock protein 70 (HSP70) inhibitor.	Quercetin	61-64	LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like	Oryctolagus cuniculus	92-97
16376383-9	2006	Among flavonoids tested, fisetin, apigenin, naringenin, luteolin, quercetin and kaempferol exhibited high inhibitory potencies for the 20alpha-HSD activity.	Quercetin	66-75	aldo-keto reductase family 1, member C18	Mus musculus	135-146
16647178-2	2006	Induction of HO-1 protein expression was detected in QUE- but not RUT- or QUI-treated C6 cells, and this was prevented by cycloheximide and actinomycin D.	Quercetin	53-56	heme oxygenase 1	Rattus norvegicus	13-17
16647178-9	2006	Adding the HO-1 inhibitors, SnPP, CoPP, and ZnPP, reversed the protective effect of QUE against H(2)O(2)- and chemical anoxia-induced cell death according to the MTT assay and morphological observations.	Quercetin	84-87	heme oxygenase 1	Rattus norvegicus	11-15
16707620-17	2006	Immunohistochemistry analysis showed that liposomal quercetin inhibited tumor angiogenesis as assessed by CD31 and induced tumor cell apoptosis.	Quercetin	52-61	platelet/endothelial cell adhesion molecule 1	Mus musculus	106-110
16226778-0	2006	Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1.	Quercetin	131-140	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	69-73
16226778-0	2006	Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1.	Quercetin	131-140	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	165-171
16226778-5	2006	In contrast, the aglycones of quercetin, kaempferol, and isorhamentin inhibited CYP1B1, CYP1A1, and CYP1A2.	Quercetin	30-39	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	80-86
16226778-5	2006	In contrast, the aglycones of quercetin, kaempferol, and isorhamentin inhibited CYP1B1, CYP1A1, and CYP1A2.	Quercetin	30-39	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
16226778-5	2006	In contrast, the aglycones of quercetin, kaempferol, and isorhamentin inhibited CYP1B1, CYP1A1, and CYP1A2.	Quercetin	30-39	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	100-106
16226778-6	2006	Among the three flavonol aglycones, isorhamentin was the most potent in inhibiting CYP1B1 (apparent Ki = 3 +/- 0.1 nM), whereas quercetin was the least potent in inhibiting CYP1A2 (apparent Ki = 418 +/- 50 nM).	Quercetin	128-137	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	173-179
16226778-9	2006	Overall, our novel findings indicate that G. biloba extract and the flavonol aglycones isorhamnetin, kaempferol, and quercetin preferentially inhibit the in vitro catalytic activity of human CYP1B1.	Quercetin	117-126	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	191-197
16710168-0	2006	Expression of Hsp70 and Hsp27 in lens epithelial cells in contused eye of rat modulated by thermotolerance or quercetin.	Quercetin	110-119	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	14-19
16710168-0	2006	Expression of Hsp70 and Hsp27 in lens epithelial cells in contused eye of rat modulated by thermotolerance or quercetin.	Quercetin	110-119	heat shock protein family B (small) member 1	Rattus norvegicus	24-29
16710168-11	2006	However, Hsp70 levels in the 1-6 h subgroup in the quercetin group was significantly lower.	Quercetin	51-60	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	9-14
16710168-14	2006	Immunostaining of Hsp70 was faint in LECs of quercetin eyes.	Quercetin	45-54	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	18-23
16611395-1	2006	The present study reports the activities of quercetin and its main circulating conjugates in man (quercetin-3"-sulphate (Q3"S) and quercetin-3-glucuronide (Q3G)) on in vivo angiogenesis induced by vascular endothelial growth factor (VEGF) and examines the effects of these molecules on cultured endothelial cells.	Quercetin	44-53	vascular endothelial growth factor A	Homo sapiens	197-231
16532021-0	2006	Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin.	Quercetin	90-99	interleukin 1 alpha	Homo sapiens	14-18
16611395-3	2006	While quercetin and Q3G inhibited VEGF-induced endothelial cell functions and angiogenesis, Q3"S per se promoted endothelial cell proliferation and angiogenesis.	Quercetin	6-15	vascular endothelial growth factor A	Homo sapiens	34-38
16532021-5	2006	We also investigated the effect of the flavonol quercetin that was recently shown to strongly inhibit IL-6 secretion in response to allergic stimulation from hCBMCs.IL-1 stimulated p38, but did not activate extracellular signal-regulated kinase (ERK) or c-jun N-terminal kinase (JNK); it also did not activate protein kinase C (PKC) isozymes alpha, beta, mu and zeta, except for PKC-theta, which was phosphorylated.	Quercetin	48-57	interleukin 6	Homo sapiens	102-106
16532021-5	2006	We also investigated the effect of the flavonol quercetin that was recently shown to strongly inhibit IL-6 secretion in response to allergic stimulation from hCBMCs.IL-1 stimulated p38, but did not activate extracellular signal-regulated kinase (ERK) or c-jun N-terminal kinase (JNK); it also did not activate protein kinase C (PKC) isozymes alpha, beta, mu and zeta, except for PKC-theta, which was phosphorylated.	Quercetin	48-57	interleukin 1 alpha	Homo sapiens	165-169
16532021-8	2006	These results indicate that IL-1-stimulated IL-6 production from human mast cells is regulated by biochemical pathways distinct from IgE-induced degranulation and that quercetin can block both IL-6 secretion and two key signal transduction steps involved.	Quercetin	168-177	interleukin 1 alpha	Homo sapiens	28-32
16532021-8	2006	These results indicate that IL-1-stimulated IL-6 production from human mast cells is regulated by biochemical pathways distinct from IgE-induced degranulation and that quercetin can block both IL-6 secretion and two key signal transduction steps involved.	Quercetin	168-177	interleukin 6	Homo sapiens	44-48
16611395-1	2006	The present study reports the activities of quercetin and its main circulating conjugates in man (quercetin-3"-sulphate (Q3"S) and quercetin-3-glucuronide (Q3G)) on in vivo angiogenesis induced by vascular endothelial growth factor (VEGF) and examines the effects of these molecules on cultured endothelial cells.	Quercetin	44-53	vascular endothelial growth factor A	Homo sapiens	233-237
16532021-8	2006	These results indicate that IL-1-stimulated IL-6 production from human mast cells is regulated by biochemical pathways distinct from IgE-induced degranulation and that quercetin can block both IL-6 secretion and two key signal transduction steps involved.	Quercetin	168-177	interleukin 6	Homo sapiens	193-197
16126241-7	2006	Finally, some of the quercetin treatments prevented the significant increase of glutathione peroxidase, superoxide dismutase, glutathione reductase and catalase activities induced by tert-butyl hydroperoxide.	Quercetin	21-30	glutathione-disulfide reductase	Homo sapiens	126-147
16614401-0	2006	Quercetin inhibits eNOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells.	Quercetin	0-9	nitric oxide synthase 3	Bos taurus	19-23
16776966-1	2006	OBJECTIVE: To investigate the effect and related mechanisms of extract of ginkgo biloba (EGb) and quercetin (Que) on angiotensin II (AngII) induced hypertrophy in the primary cultured neonatal rat cardiomyocytes.	Quercetin	98-107	angiotensinogen	Rattus norvegicus	133-138
16776966-7	2006	AngII significantly activated ERK1/2, JNK and P38 expressions and only JNK activation could be inhibited by Que and DPI.	Quercetin	108-111	angiotensinogen	Rattus norvegicus	0-5
16776966-7	2006	AngII significantly activated ERK1/2, JNK and P38 expressions and only JNK activation could be inhibited by Que and DPI.	Quercetin	108-111	mitogen-activated protein kinase 8	Rattus norvegicus	71-74
16862918-2	2006	Quercetin treatment obviously relieved the degree of hepatic fibrosis, significantly reduced the expression of immediate early gene, tissue inhibitor of metalloproteinase 1 (TIMP 1), types I and III collagen compared to the control.	Quercetin	0-9	jun proto-oncogene	Mus musculus	111-126
16862918-2	2006	Quercetin treatment obviously relieved the degree of hepatic fibrosis, significantly reduced the expression of immediate early gene, tissue inhibitor of metalloproteinase 1 (TIMP 1), types I and III collagen compared to the control.	Quercetin	0-9	tissue inhibitor of metalloproteinase 1	Mus musculus	133-172
16862918-2	2006	Quercetin treatment obviously relieved the degree of hepatic fibrosis, significantly reduced the expression of immediate early gene, tissue inhibitor of metalloproteinase 1 (TIMP 1), types I and III collagen compared to the control.	Quercetin	0-9	tissue inhibitor of metalloproteinase 1	Mus musculus	174-180
16618767-0	2006	Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity.	Quercetin	97-106	peroxiredoxin 5	Homo sapiens	24-45
16618767-11	2006	Thus, the anticancer activity of quercetin and myricetin may be due to inhibition of TrxR, consequently inducing cell death.	Quercetin	33-42	peroxiredoxin 5	Homo sapiens	85-89
16516418-2	2006	This study investigated the effect of quercetin, a dual inhibitor of CYP3A4 and P-gp, on the bioavailability and pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, in rats.	Quercetin	38-47	phosphoglycolate phosphatase	Rattus norvegicus	80-84
16126241-7	2006	Finally, some of the quercetin treatments prevented the significant increase of glutathione peroxidase, superoxide dismutase, glutathione reductase and catalase activities induced by tert-butyl hydroperoxide.	Quercetin	21-30	catalase	Homo sapiens	152-160
16600019-0	2006	Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells.	Quercetin	11-20	insulin like growth factor binding protein 3	Homo sapiens	88-95
16600019-5	2006	METHODS: We evaluated the secretion of IGF-I, -II and IGFBP-3 in quercetin treated cells by immunoradiometric (IRMA) method.	Quercetin	65-74	insulin like growth factor 1	Homo sapiens	39-49
16600019-5	2006	METHODS: We evaluated the secretion of IGF-I, -II and IGFBP-3 in quercetin treated cells by immunoradiometric (IRMA) method.	Quercetin	65-74	insulin like growth factor binding protein 3	Homo sapiens	54-61
16600019-12	2006	The increased level of IGFBP-3 was associated with increased pro-apoptotic proteins and apoptosis in response to quercetin, suggesting it may be a p53-independent effector of apoptosis in prostate cancer cells.	Quercetin	113-122	insulin like growth factor binding protein 3	Homo sapiens	23-30
16222712-8	2006	Apigenin and Quercetin, but not Tamoxifen, were found to inhibit VCAM-1 expression in a dose-dependent manner in HUVEC and in murine pulmonary endothelial cells.	Quercetin	13-22	vascular cell adhesion molecule 1	Mus musculus	65-71
16595910-13	2006	Phloretin (5), 3-hydroxyphloretin (6), and quercetin (7) showed better inhibition of MMP-1 production in fibroblast cells.	Quercetin	43-52	matrix metallopeptidase 1	Homo sapiens	85-90
16443667-9	2006	The formation of M4 by human liver microsomes was inhibited 72% by 50 microM quercetin, suggesting that the formation of M4 was mediated via CYP2C8.	Quercetin	77-86	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	141-147
16458870-4	2006	In our preliminary study, we investigated the effect of flavonoids including luteolin, quercetin, baicalein, genistein, taxifolin and catechin on HGF-mediated migration and invasion of HepG2 cells.	Quercetin	87-96	hepatocyte growth factor	Homo sapiens	146-149
16579653-3	2006	The heat preconditioning transiently up-regulated the Hsp levels in Hsf1 wild-type cells and significantly improved their postirradiation survival; these effects could be abolished by quercetin or simulated (without preheating) by the Hsf1 overexpression.	Quercetin	184-193	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	54-57
16579653-3	2006	The heat preconditioning transiently up-regulated the Hsp levels in Hsf1 wild-type cells and significantly improved their postirradiation survival; these effects could be abolished by quercetin or simulated (without preheating) by the Hsf1 overexpression.	Quercetin	184-193	heat shock transcription factor 1	Homo sapiens	68-72
16442130-11	2006	Conversely, long-term exposure of herbal agents (hyperforin, kaempferol and quercetin) showed enhanced expression of CYP3A4 mRNA in Caco-2 cells.	Quercetin	76-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	117-123
16442130-12	2006	In another study, we observed that long-term exposure of hypericin, kaempferol, quercetin and silibinin resulted in higher MDR-1 mRNA expression in Caco-2 cells.	Quercetin	80-89	ATP binding cassette subfamily B member 1	Homo sapiens	123-128
16802696-6	2006	In porcine pancreatic alpha-amylase, luteolin, myricetin and quercetin were potent inhibitors with the IC50 values less than 500 microM.	Quercetin	61-70	amylase 2a3	Rattus norvegicus	11-35
16407180-0	2006	Docking studies show that D-glucose and quercetin slide through the transporter GLUT1.	Quercetin	40-49	solute carrier family 2 member 1	Homo sapiens	80-85
16434028-8	2006	In RAW264.7 cells, a monocyte/macrophage precursor for osteoclasts, both kaempferol and quercetin dose-dependently inhibited the receptor activator of NF-kappaB ligand (RANKL)-induced immediate-early oncogene c-fos expression at 6 h. After 3-5 days, both flavonols robustly inhibited RANKL-induced expression of the osteoclastic differentiation markers, RANK and calcitonin receptor.	Quercetin	88-97	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	129-167
16434028-8	2006	In RAW264.7 cells, a monocyte/macrophage precursor for osteoclasts, both kaempferol and quercetin dose-dependently inhibited the receptor activator of NF-kappaB ligand (RANKL)-induced immediate-early oncogene c-fos expression at 6 h. After 3-5 days, both flavonols robustly inhibited RANKL-induced expression of the osteoclastic differentiation markers, RANK and calcitonin receptor.	Quercetin	88-97	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	169-174
16434028-8	2006	In RAW264.7 cells, a monocyte/macrophage precursor for osteoclasts, both kaempferol and quercetin dose-dependently inhibited the receptor activator of NF-kappaB ligand (RANKL)-induced immediate-early oncogene c-fos expression at 6 h. After 3-5 days, both flavonols robustly inhibited RANKL-induced expression of the osteoclastic differentiation markers, RANK and calcitonin receptor.	Quercetin	88-97	jun proto-oncogene	Mus musculus	184-199
16434028-8	2006	In RAW264.7 cells, a monocyte/macrophage precursor for osteoclasts, both kaempferol and quercetin dose-dependently inhibited the receptor activator of NF-kappaB ligand (RANKL)-induced immediate-early oncogene c-fos expression at 6 h. After 3-5 days, both flavonols robustly inhibited RANKL-induced expression of the osteoclastic differentiation markers, RANK and calcitonin receptor.	Quercetin	88-97	FBJ osteosarcoma oncogene	Mus musculus	209-214
16434028-8	2006	In RAW264.7 cells, a monocyte/macrophage precursor for osteoclasts, both kaempferol and quercetin dose-dependently inhibited the receptor activator of NF-kappaB ligand (RANKL)-induced immediate-early oncogene c-fos expression at 6 h. After 3-5 days, both flavonols robustly inhibited RANKL-induced expression of the osteoclastic differentiation markers, RANK and calcitonin receptor.	Quercetin	88-97	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	284-289
16434028-10	2006	However, kaempferol was more potent than quercetin in inhibiting RANKL-stimulated effects on RAW264.7 cells.	Quercetin	41-50	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	65-70
16619521-0	2006	The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway.	Quercetin	32-41	AKT serine/threonine kinase 1	Homo sapiens	97-100
16619521-8	2006	Pre-exposing T47D cells to Qu (25 microM) or LY (10 microM) abrogated EGF-induced Akt/PKB phosphorylation at Ser-473.	Quercetin	27-29	AKT serine/threonine kinase 1	Homo sapiens	82-85
16619521-8	2006	Pre-exposing T47D cells to Qu (25 microM) or LY (10 microM) abrogated EGF-induced Akt/PKB phosphorylation at Ser-473.	Quercetin	27-29	AKT serine/threonine kinase 1	Homo sapiens	86-89
16522772-4	2006	We investigated the anti-inflammatory potentials of a safe, common dietary flavonoid component, quercetin, for its ability to modulate the production and gene expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) by human peripheral blood mononuclear cells (PBMC).	Quercetin	96-105	tumor necrosis factor	Homo sapiens	202-229
16522772-0	2006	The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system.	Quercetin	14-23	tumor necrosis factor	Homo sapiens	59-86
16522772-4	2006	We investigated the anti-inflammatory potentials of a safe, common dietary flavonoid component, quercetin, for its ability to modulate the production and gene expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) by human peripheral blood mononuclear cells (PBMC).	Quercetin	96-105	tumor necrosis factor	Homo sapiens	231-240
16522772-5	2006	Our results showed that quercetin significantly inhibited TNF-alpha production and gene expression in a dose-dependent manner.	Quercetin	24-33	tumor necrosis factor	Homo sapiens	58-67
16522772-6	2006	Our results provide direct evidence of the anti-inflammatory effects of quercetin by PBMC, which are mediated by the inhibition of the proinflammatory cytokine TNF-alpha via modulation of NF-kappabeta1 and Ikappabeta.	Quercetin	72-81	tumor necrosis factor	Homo sapiens	160-169
16381670-7	2006	Cotreatment of the oral tissue with dietary polyphenols, including resveratrol and quercetin, and BaP, resulted in significant inhibition of the BaP-DNA binding.	Quercetin	83-92	prohibitin 2	Homo sapiens	145-148
17012770-11	2006	At week 33, the expression of iNOS was reduced by quercetin without a statistical significance, and COX-2 expression was slightly reduced in rats on beta-carotene supplementation.	Quercetin	50-59	nitric oxide synthase 2	Rattus norvegicus	30-34
16289744-11	2006	A number of flavonoids including fisetin, galangin, quercetin, kaempferol, and genistein represent potent non-competitive inhibitors of sulfotransferase 1A1 (or P-PST); this may represent an important mechanism for the chemoprevention of sulfation-induced carcinogenesis.	Quercetin	52-61	sulfotransferase family 1A member 1	Homo sapiens	136-156
16289744-11	2006	A number of flavonoids including fisetin, galangin, quercetin, kaempferol, and genistein represent potent non-competitive inhibitors of sulfotransferase 1A1 (or P-PST); this may represent an important mechanism for the chemoprevention of sulfation-induced carcinogenesis.	Quercetin	52-61	sulfotransferase family 1A member 1	Homo sapiens	161-166
16021489-9	2006	In addition, curcuminoids did not affect 8-azido[alpha-(32)P]ATP binding, however they did stimulate the basal ATPase activity and inhibited the quercetin-stimulated ATP hydrolysis of MRP1 indicating that these bioflavonoids interact most likely at the substrate-binding site(s).	Quercetin	145-154	ATP binding cassette subfamily C member 1	Homo sapiens	184-188
16316652-0	2006	Quercetin, a bioflavonoid, accelerates TNF-alpha-induced growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells.	Quercetin	0-9	tumor necrosis factor	Mus musculus	39-48
16316652-2	2006	This study examined how quercetin acts on tumor necrosis factor-alpha (TNF-alpha)-mediated growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells.	Quercetin	24-33	tumor necrosis factor	Mus musculus	42-69
16316652-2	2006	This study examined how quercetin acts on tumor necrosis factor-alpha (TNF-alpha)-mediated growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells.	Quercetin	24-33	tumor necrosis factor	Mus musculus	71-80
16316652-3	2006	Tritium uptake assay showed that a quercetin treatment accelerated TNF-alpha-induced inhibition of DNA synthesis in the cells in a dose-dependent manner.	Quercetin	35-44	tumor necrosis factor	Mus musculus	67-76
16316652-4	2006	Both the 3-(4,5-dimethylthiazol-2yl-)-2,5-diphenyl tetrazolium bromide and trypan blue staining assays also showed the quercetin-mediated facilitation of TNF-alpha-induced cytotoxicity in the cells.	Quercetin	119-128	tumor necrosis factor	Mus musculus	154-163
16316652-5	2006	Apoptosis assays revealed an accelerating effect of quercetin on TNF-alpha-induced apoptosis in MC3T3-E1 cells.	Quercetin	52-61	tumor necrosis factor	Mus musculus	65-74
16316652-6	2006	In addition, Fas activation and poly (ADP ribose) polymerase cleavage are thought to be closely associated with the TNF-alpha-induced apoptosis and its acceleration by the quercetin treatment in the cells.	Quercetin	172-181	tumor necrosis factor	Mus musculus	116-125
16497619-6	2006	Furthermore, quercetin, an inhibitor of HSP70 synthesis, diminished the protective effects of GGA in IEC-18 cells upon NH(2)Cl-caused injury.	Quercetin	13-22	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	40-45
15782287-6	2006	High doses of quercetin (50-100 microM) increased glutathione concentration and gene expression of Cu/Zn superoxide dismutase and catalase inhibiting the activity of the latter enzyme, whereas lower doses (0.1-1 microM) decreased gene expression of Cu/Zn superoxide dismutase and increased that of glutathione peroxidase.	Quercetin	14-23	catalase	Homo sapiens	130-138
16826916-3	2006	In the B-R buffer solution at pH 4.00, the RLS intensity at 497 nm was maximum and proportional to the concentration of quercetin.	Quercetin	120-129	RLS1	Homo sapiens	43-46
16826916-5	2006	Quantum chemistry calculation showed that this enhancement of RLS occurred because the neutral molecules of quercetin assembled into super-molecular aggregates by 4-4" hydrogen-bond.	Quercetin	108-117	RLS1	Homo sapiens	62-65
16451754-4	2006	The glycosides rutin and quercitrin gave dose-dependent increases in GST activity, with a 50% and 24.5% increase at 250 mM, respectively, while the aglycone quercetin inhibited the enzyme by 30% at 250 mM.	Quercetin	157-166	glutathione S-transferase kappa 1	Homo sapiens	69-72
16168661-5	2006	The flavonoid quercetin inhibited Hsp27 induction and abrogated simvastatin-mediated neuroprotection.	Quercetin	14-23	heat shock protein family B (small) member 1	Rattus norvegicus	34-39
16271822-3	2006	While seven flavonoids (myricetin, apigenin, kaempferol, quercetin, amentoflavone, quercitrin and rutin) were slightly more selective for CYP 1B1 EROD inhibition (K(i)s 0.06-5.96 microM) compared to CYP 1A1 (K(i)s 0.20-1.6 microM) the difference in K(i)s for the P450s were not significantly different.	Quercetin	57-66	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	138-145
16316652-7	2006	Collectively, this study showed that quercetin accelerates the TNF-alpha-induced growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells.	Quercetin	37-46	tumor necrosis factor	Mus musculus	63-72
17100629-4	2006	Treatment with flavonoids such as luteolin, apigenin, quercetin, genistein, (-)-epigallocatechin gallate, and anthocyanidin resulted in significant downregulation of LPS-elicited TNF-alpha and nitric oxide (NO) production and diminished lethal shock.	Quercetin	54-63	tumor necrosis factor	Mus musculus	179-188
16601352-9	2006	Of the six flavonoids examined, luteolin, apigenin, fisetin and quercetin at 30 microM showed a significant inhibitory effect on CD40 ligand expression.	Quercetin	64-73	CD40 molecule	Homo sapiens	129-133
16331104-0	2006	Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats.	Quercetin	0-9	nitric oxide synthase 3	Rattus norvegicus	49-53
17191019-0	2006	Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line.	Quercetin	21-30	C-C motif chemokine ligand 2	Homo sapiens	47-52
16331104-10	2006	CONCLUSIONS: Enhanced eNOS activity and decreased NADPH oxidase-mediated superoxide anion (O2) generation associated with reduced p47 expression appear to be essential mechanisms for the improvement of endothelial function and the antihypertensive effects of chronic quercetin.	Quercetin	267-276	NSFL1 cofactor	Rattus norvegicus	130-133
17191019-0	2006	Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line.	Quercetin	21-30	carboxyl ester lipase pseudogene	Homo sapiens	133-139
17191019-5	2006	In this study quercetin inhibits, in a dose-response manner, tryptase and MCP-1.	Quercetin	14-23	C-C motif chemokine ligand 2	Homo sapiens	74-79
17191019-6	2006	Moreover, using RT-PCR quercetin inhibited the transcription of histidine decarboxylase, the rate-limiting enzyme responsible for the generation of histamine from histidine, and MCP-1.	Quercetin	23-32	histidine decarboxylase	Homo sapiens	64-87
17191019-6	2006	Moreover, using RT-PCR quercetin inhibited the transcription of histidine decarboxylase, the rate-limiting enzyme responsible for the generation of histamine from histidine, and MCP-1.	Quercetin	23-32	C-C motif chemokine ligand 2	Homo sapiens	178-183
16507510-9	2006	The kinetics of inhibition of NAT1 by caffeic acid, EGCG and quercetin were of the non-competitive type, whereas that of NAT2 by quercetin, curcumin and kaemferol was also of the non-competitive type.	Quercetin	61-70	N-acetyltransferase 1	Homo sapiens	30-34
16898267-0	2006	Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3.	Quercetin	0-9	tumor protein p53	Homo sapiens	18-21
16898267-0	2006	Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	89-94
16898267-0	2006	Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3.	Quercetin	0-9	insulin like growth factor binding protein 3	Homo sapiens	137-144
16898267-2	2006	We report insulin-like growth factor-binding protein-3 (IGFBP-3) as an effector of quercetin-induced apoptosis in human prostate cancer cell lines in a p53-independent manner.	Quercetin	83-92	insulin like growth factor binding protein 3	Homo sapiens	10-54
16898267-2	2006	We report insulin-like growth factor-binding protein-3 (IGFBP-3) as an effector of quercetin-induced apoptosis in human prostate cancer cell lines in a p53-independent manner.	Quercetin	83-92	insulin like growth factor binding protein 3	Homo sapiens	56-63
16898267-2	2006	We report insulin-like growth factor-binding protein-3 (IGFBP-3) as an effector of quercetin-induced apoptosis in human prostate cancer cell lines in a p53-independent manner.	Quercetin	83-92	tumor protein p53	Homo sapiens	152-155
16898267-3	2006	We evaluated the production of IGFBP-3 in quercetin-treated cells.	Quercetin	42-51	insulin like growth factor binding protein 3	Homo sapiens	31-38
16898267-7	2006	In quercetin-treated PC-3 cells, an increase in Bax protein expression and a decrease in Bcl-x(L) protein and Bcl-2 protein were observed.	Quercetin	3-12	BCL2 associated X, apoptosis regulator	Homo sapiens	48-51
16898267-7	2006	In quercetin-treated PC-3 cells, an increase in Bax protein expression and a decrease in Bcl-x(L) protein and Bcl-2 protein were observed.	Quercetin	3-12	BCL2 like 1	Homo sapiens	89-97
16898267-7	2006	In quercetin-treated PC-3 cells, an increase in Bax protein expression and a decrease in Bcl-x(L) protein and Bcl-2 protein were observed.	Quercetin	3-12	BCL2 apoptosis regulator	Homo sapiens	110-115
16898267-9	2006	The level of IGFBP-3 on the response of PC-3 cells to quercetin was examined.	Quercetin	54-63	insulin like growth factor binding protein 3	Homo sapiens	13-20
16898267-10	2006	There was a twofold increase in IGFBP-3 level in conditioned media of 100 microM quercetin-treated cells.	Quercetin	81-90	insulin like growth factor binding protein 3	Homo sapiens	32-39
16898267-12	2006	Thus, increased level of IGFBP-3 was associated with increased proapoptotic proteins and apoptosis in response to quercetin, suggesting it may be a p53-independent effector of apoptosis in prostate cancer cells via its modulation of the Bax/Bcl-2 protein ratio.	Quercetin	114-123	insulin like growth factor binding protein 3	Homo sapiens	25-32
16226777-0	2006	Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats.	Quercetin	10-19	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	67-83
16226777-10	2006	MT-1 and MT-2 mRNA levels in kidney were substantially increased during treatment with Cd, being even higher when the animals received Cd and quercetin.	Quercetin	142-151	metallothionein 1	Rattus norvegicus	0-13
16226777-14	2006	Our results demonstrate that quercetin treatment prevents Cd-induced overexpression of iNOS and COX-2, and increases MT expression.	Quercetin	29-38	nitric oxide synthase 2	Rattus norvegicus	87-91
16226777-14	2006	Our results demonstrate that quercetin treatment prevents Cd-induced overexpression of iNOS and COX-2, and increases MT expression.	Quercetin	29-38	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	96-101
16507510-9	2006	The kinetics of inhibition of NAT1 by caffeic acid, EGCG and quercetin were of the non-competitive type, whereas that of NAT2 by quercetin, curcumin and kaemferol was also of the non-competitive type.	Quercetin	129-138	N-acetyltransferase 2	Homo sapiens	121-125
16507510-10	2006	The most potent inhibitor was quercetin, which has the inhibitory constants for NAT1 and NAT2 of 48.6 +/- 17.3 and 10.0 +/- 1.8 microM, respectively.	Quercetin	30-39	N-acetyltransferase 1	Homo sapiens	80-84
16507510-10	2006	The most potent inhibitor was quercetin, which has the inhibitory constants for NAT1 and NAT2 of 48.6 +/- 17.3 and 10.0 +/- 1.8 microM, respectively.	Quercetin	30-39	N-acetyltransferase 2	Homo sapiens	89-93
16737615-0	2006	[Effects of quercetin on morphology and VEGF secretion of leukemia cells NB4 in vitro].	Quercetin	12-21	vascular endothelial growth factor A	Homo sapiens	40-44
16737615-4	2006	Apoptotic marker Annexin V analysis showed that the apoptotic rate of NB4 cells was increased after treatment with quercetin.	Quercetin	115-124	annexin A5	Homo sapiens	17-26
16737615-5	2006	The secretion of VEGF of NB4 cells was significantly decreased after treatment with quercetin.	Quercetin	84-93	vascular endothelial growth factor A	Homo sapiens	17-21
16737615-6	2006	CONCLUSION: Quercetin can induce apoptosis and inhibit secretion of VEGF in NB4 leukemia cells.	Quercetin	12-21	vascular endothelial growth factor A	Homo sapiens	68-72
16426496-0	2005	The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils.	Quercetin	25-34	interleukin 6	Homo sapiens	38-42
16601819-0	2005	The effect of quercetin and galangin on glutathione reductase.	Quercetin	14-23	glutathione-disulfide reductase	Homo sapiens	40-61
16601819-1	2005	Quercetin and galangin can change the activity of glutathione reductase.	Quercetin	0-9	glutathione-disulfide reductase	Homo sapiens	50-71
16359181-1	2005	This study investigates the role of cellular tyrosinase and/or peroxidase-like oxidative enzyme activity in the covalent binding of quercetin to glutathione, protein, and DNA, as well as the stability of quercetin DNA adducts in time.	Quercetin	132-141	tyrosinase	Homo sapiens	45-55
16359181-3	2005	Cells with elevated tyrosinase or peroxidase levels contained approximately 2 times higher levels of covalent quercetin adducts than cells without detectable levels of these oxidative enzymes.	Quercetin	110-119	tyrosinase	Homo sapiens	20-30
16426496-3	2005	In the present study, we investigated the effects of quercetin on IL-6 production by LPS-stimulated neutrophils in human.	Quercetin	53-62	interleukin 6	Homo sapiens	66-70
16005451-6	2005	The oxidation of apoAI on exposure to the lights was inhibited by quercetin, an antioxidant.	Quercetin	66-75	apolipoprotein A1	Homo sapiens	17-22
16426496-7	2005	However, after pre-treatment of neutrophils with quercetin (40 microM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated.	Quercetin	49-58	interleukin 6	Homo sapiens	131-135
16426496-7	2005	However, after pre-treatment of neutrophils with quercetin (40 microM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated.	Quercetin	49-58	interleukin 6	Homo sapiens	161-165
16426496-7	2005	However, after pre-treatment of neutrophils with quercetin (40 microM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated.	Quercetin	49-58	interleukin 6	Homo sapiens	161-165
16426496-9	2005	Thus, our data suggested that quercetin might exert its anti-inflammatory effect through negatively modulating pro-inflammatory factors, such as IL-6.	Quercetin	30-39	interleukin 6	Homo sapiens	145-149
16426496-10	2005	The inhibitory effects of quercetin on IL-6 production by neutrophils may provide a theoretical basis on future therapy of inflammation.	Quercetin	26-35	interleukin 6	Homo sapiens	39-43
16838923-4	2005	Among the three potential sites of chelation present in the quercetin structure, the catechol function presents the highest complexation power toward Pb(II), in opposition with previous results found for Al(III) complexation.	Quercetin	60-69	submaxillary gland androgen regulated protein 3B	Homo sapiens	150-156
16389571-1	2005	OBJECTIVE: To investigate the effects of quercetin, an herbal flavonoid, on LPS-induced delay in spontaneous apoptosis, adhesion molecules (CD62L, CD11b/CD18) expression of neutrophils, and superoxide (O(2)(-)) generation by LPS-primed fMLP-induced human neutrophils.	Quercetin	41-50	formyl peptide receptor 1	Homo sapiens	236-240
16389571-9	2005	Quercetin (40 microM) also prevented LPS-induced down-regulation of CD62L expression, up-regulation of CD11b/CD18 expression, and O(2) (-) generation by fMLP-induced neutrophils.	Quercetin	0-9	selectin L	Homo sapiens	68-73
16389571-9	2005	Quercetin (40 microM) also prevented LPS-induced down-regulation of CD62L expression, up-regulation of CD11b/CD18 expression, and O(2) (-) generation by fMLP-induced neutrophils.	Quercetin	0-9	integrin subunit alpha M	Homo sapiens	103-108
16389571-9	2005	Quercetin (40 microM) also prevented LPS-induced down-regulation of CD62L expression, up-regulation of CD11b/CD18 expression, and O(2) (-) generation by fMLP-induced neutrophils.	Quercetin	0-9	integrin subunit beta 2	Homo sapiens	109-113
16389571-9	2005	Quercetin (40 microM) also prevented LPS-induced down-regulation of CD62L expression, up-regulation of CD11b/CD18 expression, and O(2) (-) generation by fMLP-induced neutrophils.	Quercetin	0-9	formyl peptide receptor 1	Homo sapiens	153-157
16379584-11	2005	Quercetin significantly prevented decrease of glutathione levels and decreased myeloperoxidase activity.	Quercetin	0-9	myeloperoxidase	Rattus norvegicus	79-94
16389571-1	2005	OBJECTIVE: To investigate the effects of quercetin, an herbal flavonoid, on LPS-induced delay in spontaneous apoptosis, adhesion molecules (CD62L, CD11b/CD18) expression of neutrophils, and superoxide (O(2)(-)) generation by LPS-primed fMLP-induced human neutrophils.	Quercetin	41-50	integrin subunit alpha M	Homo sapiens	147-152
16389571-1	2005	OBJECTIVE: To investigate the effects of quercetin, an herbal flavonoid, on LPS-induced delay in spontaneous apoptosis, adhesion molecules (CD62L, CD11b/CD18) expression of neutrophils, and superoxide (O(2)(-)) generation by LPS-primed fMLP-induced human neutrophils.	Quercetin	41-50	integrin subunit beta 2	Homo sapiens	153-157
16358785-12	2005	Nordihydroguaretic acid, quercetin, and dihydroquercetin, but not suramin, also interact with calmodulin, but this does not result in the complete closing of its hydrophobic site.	Quercetin	25-34	calmodulin 2	Mus musculus	94-104
16323269-8	2005	The activity of quercetin, for example, has been at least partially attributed to inhibition of DNA gyrase.	Quercetin	16-25	DNA topoisomerase II alpha	Homo sapiens	96-106
16049707-0	2005	Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression.	Quercetin	0-9	H3 histone pseudogene 16	Homo sapiens	119-122
16049707-3	2005	In this study, we investigated the effects of quercetin on proliferation and cell cycle arrest by modulation of Cdc2/Cdk-1 protein in prostate cancer cells (PC-3).	Quercetin	46-55	cyclin dependent kinase 1	Homo sapiens	112-116
16049707-3	2005	In this study, we investigated the effects of quercetin on proliferation and cell cycle arrest by modulation of Cdc2/Cdk-1 protein in prostate cancer cells (PC-3).	Quercetin	46-55	cyclin dependent kinase 1	Homo sapiens	117-122
16049707-6	2005	Addition of quercetin led to substantial decrease in the expression of Cdc2/Cdk-1, cyclin B1 and phosphorylated pRb and increase in p21.	Quercetin	12-21	cyclin dependent kinase 1	Homo sapiens	71-75
16049707-6	2005	Addition of quercetin led to substantial decrease in the expression of Cdc2/Cdk-1, cyclin B1 and phosphorylated pRb and increase in p21.	Quercetin	12-21	cyclin dependent kinase 1	Homo sapiens	76-81
16049707-6	2005	Addition of quercetin led to substantial decrease in the expression of Cdc2/Cdk-1, cyclin B1 and phosphorylated pRb and increase in p21.	Quercetin	12-21	cyclin B1	Homo sapiens	83-92
16049707-6	2005	Addition of quercetin led to substantial decrease in the expression of Cdc2/Cdk-1, cyclin B1 and phosphorylated pRb and increase in p21.	Quercetin	12-21	RB transcriptional corepressor 1	Homo sapiens	112-115
16049707-6	2005	Addition of quercetin led to substantial decrease in the expression of Cdc2/Cdk-1, cyclin B1 and phosphorylated pRb and increase in p21.	Quercetin	12-21	H3 histone pseudogene 16	Homo sapiens	132-135
16171798-0	2005	Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.	Quercetin	38-47	nitric oxide synthase 2, inducible	Mus musculus	14-18
16211300-0	2005	Quercetin induces gadd45 expression through a p53-independent pathway.	Quercetin	0-9	growth arrest and DNA damage inducible alpha	Homo sapiens	18-24
16211300-0	2005	Quercetin induces gadd45 expression through a p53-independent pathway.	Quercetin	0-9	tumor protein p53	Homo sapiens	46-49
16211300-3	2005	We show for the first time that gadd45 is a molecular target of quercetin, which inhibits growth of human cervical cancer HeLa cells.	Quercetin	64-73	growth arrest and DNA damage inducible alpha	Homo sapiens	32-38
16211300-7	2005	Quercetin did not activate transcription through p53-binding sites in HeLa cells, although it up-regulated gadd45 in p53-inactivated tumor cells.	Quercetin	0-9	growth arrest and DNA damage inducible alpha	Homo sapiens	107-113
16211300-7	2005	Quercetin did not activate transcription through p53-binding sites in HeLa cells, although it up-regulated gadd45 in p53-inactivated tumor cells.	Quercetin	0-9	tumor protein p53	Homo sapiens	117-120
16211300-8	2005	These results indicate that quercetin induces gadd45 expression in a p53-independent manner.	Quercetin	28-37	growth arrest and DNA damage inducible alpha	Homo sapiens	46-52
16211300-8	2005	These results indicate that quercetin induces gadd45 expression in a p53-independent manner.	Quercetin	28-37	tumor protein p53	Homo sapiens	69-72
16247336-9	2005	Furthermore, the protective effect of GGA on mortality in LPS-treated rats was inhibited with quercetin, known as an HSP70 inhibitor.	Quercetin	94-103	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	117-122
16171798-7	2005	The involvement of signal pathways in quercetin-induced heme oxygenase-1 gene expression was associated with tyrosine kinase and mitogen-activated protein kinases activation.	Quercetin	38-47	heme oxygenase 1	Mus musculus	56-72
16171798-0	2005	Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.	Quercetin	38-47	signal transducer and activator of transcription 1	Mus musculus	124-129
16171798-1	2005	In the present study, experiments were performed to explore the action of quercetin, the most widely distributed flavonoids, and its major metabolite, quercetin-3"-sulfate, on lipopolysaccharide (LPS)- and interferon-gamma (IFN-gamma)-induced nitric oxide (NO) production in BV-2 microglia.	Quercetin	74-83	interferon gamma	Mus musculus	206-233
16171798-2	2005	Quercetin could suppress LPS- and IFN-gamma-induced NO production and inducible nitric oxide synthase (iNOS) gene transcription, while quercetin-3"-sulfate had no effect.	Quercetin	0-9	interferon gamma	Mus musculus	34-43
16171798-2	2005	Quercetin could suppress LPS- and IFN-gamma-induced NO production and inducible nitric oxide synthase (iNOS) gene transcription, while quercetin-3"-sulfate had no effect.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	70-101
16171798-2	2005	Quercetin could suppress LPS- and IFN-gamma-induced NO production and inducible nitric oxide synthase (iNOS) gene transcription, while quercetin-3"-sulfate had no effect.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	103-107
16171798-3	2005	LPS-induced IkappaB kinase (IKK), nuclear factor-kappaB (NF-kappaB) and activating protein-1 (AP-1) activation, and IFN-gamma-induced NF-kappaB, signal transducer and activator of transcription-1 (STAT1) and interferon regulatory factor-1 (IRF-1) activation were reduced by quercetin.	Quercetin	274-283	interferon gamma	Mus musculus	116-125
16171798-4	2005	Moreover quercetin was able to induce heme oxygenase-1 expression.	Quercetin	9-18	heme oxygenase 1	Mus musculus	38-54
16171798-6	2005	Quercetin-mediated inhibition of NO production and iNOS protein expression were partially reversed by heme oxygenase-1 antisense oligodeoxynucleotide, but was mimicked by hemin, a heme oxygenase-1 inducer.	Quercetin	0-9	nitric oxide synthase 2, inducible	Mus musculus	51-55
16171798-6	2005	Quercetin-mediated inhibition of NO production and iNOS protein expression were partially reversed by heme oxygenase-1 antisense oligodeoxynucleotide, but was mimicked by hemin, a heme oxygenase-1 inducer.	Quercetin	0-9	heme oxygenase 1	Mus musculus	102-118
16171798-6	2005	Quercetin-mediated inhibition of NO production and iNOS protein expression were partially reversed by heme oxygenase-1 antisense oligodeoxynucleotide, but was mimicked by hemin, a heme oxygenase-1 inducer.	Quercetin	0-9	heme oxygenase 1	Mus musculus	180-196
16335816-4	2005	Flavonoid compounds and their derivates from traditional medicinal herbs are active inhibitors to aldose reductase, such as quercetin, silymarin, puerarin, baicalim, berberine and so on.	Quercetin	124-133	aldo-keto reductase family 1 member B	Homo sapiens	98-114
16270650-0	2005	The polyphenols quercetin and catechin synergize in inhibiting platelet CD40L expression.	Quercetin	16-25	CD40 ligand	Homo sapiens	72-77
16177186-0	2005	Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats.	Quercetin	0-9	nitric oxide synthase 2	Rattus norvegicus	64-68
16177186-2	2005	This study investigated the protective effects of quercetin treatment on oxidative stress, nuclear factor (NF)-kappaB activation and expression of inducible nitric oxide synthase (iNOS) in streptozotocin-induced diabetic rats.	Quercetin	50-59	nitric oxide synthase 2	Rattus norvegicus	180-184
16177186-9	2005	Streptozotocin administration induced significant increases in hepatic TBARS concentration, QL, and SOD and catalase activities that were prevented by quercetin.	Quercetin	151-160	catalase	Rattus norvegicus	108-116
16261515-2	2005	All the flavonoids assayed showed an inhibitory effect on the intact microsomal G-6-Pase: quercetin and kaempferol exhibited the lowest effect; astilbin, quercetin 3-O-alpha-rhamnoside, kaempferol 3-O-alpha-rhamnoside and quercetin 3-O-alpha-arabinoside an intermediate effect.	Quercetin	90-99	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	80-88
16393854-3	2005	The present work obtained active UGT1A9 and UGT1A3 enzymes with a Bac-to-Bac expression system, and quercetin was metabolized by each of them to four monoglucuronides (7-, 3-, 4"- and 3"-glucuronide).	Quercetin	100-109	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	33-39
16393854-3	2005	The present work obtained active UGT1A9 and UGT1A3 enzymes with a Bac-to-Bac expression system, and quercetin was metabolized by each of them to four monoglucuronides (7-, 3-, 4"- and 3"-glucuronide).	Quercetin	100-109	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	44-50
16393854-4	2005	Enzymatic kinetic parameters of each glucuronide were calculated to elucidate quantitatively UGT1A9"s and UGT1A3"s regioselectivities for quercetin.	Quercetin	138-147	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	93-99
16393854-4	2005	Enzymatic kinetic parameters of each glucuronide were calculated to elucidate quantitatively UGT1A9"s and UGT1A3"s regioselectivities for quercetin.	Quercetin	138-147	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	106-112
16082193-5	2005	Quercetin caused a downregulation of Cu-Zn Superoxide Dismutase which perhaps led to an increase of reactive oxidative stress (ROS).	Quercetin	0-9	superoxide dismutase 1	Homo sapiens	37-63
16109301-7	2005	Quercetin (10--40 microM), also a flavonoid, also inhibited hemin-induced HO-1 expression.	Quercetin	0-9	heme oxygenase 1	Mus musculus	74-78
16112498-2	2005	BACKGROUND: QR-333, a topical compound that contains quercetin, a flavonoid with aldose reductase inhibitor effects, ascorbyl palmitate, and vitamin D(3), was formulated to decrease the oxidative stress that contributes to peripheral diabetic neuropathy and thus alleviate its symptoms.	Quercetin	53-62	aldo-keto reductase family 1 member B	Homo sapiens	81-97
16156793-3	2005	This study investigates the interactions of six common polyphenols; quercetin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5.	Quercetin	68-77	ATP binding cassette subfamily C member 1	Homo sapiens	190-194
16156793-3	2005	This study investigates the interactions of six common polyphenols; quercetin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5.	Quercetin	68-77	ATP binding cassette subfamily C member 4	Homo sapiens	196-200
16156793-3	2005	This study investigates the interactions of six common polyphenols; quercetin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5.	Quercetin	68-77	ATP binding cassette subfamily C member 5	Homo sapiens	205-209
16156793-7	2005	Also, both quercetin and silymarin were found to inhibit MRP1-, MRP4- and MRP5-mediated transport from intact cells with high affinity.	Quercetin	11-20	ATP binding cassette subfamily C member 1	Homo sapiens	57-61
16156793-7	2005	Also, both quercetin and silymarin were found to inhibit MRP1-, MRP4- and MRP5-mediated transport from intact cells with high affinity.	Quercetin	11-20	ATP binding cassette subfamily C member 4	Homo sapiens	64-68
16156793-7	2005	Also, both quercetin and silymarin were found to inhibit MRP1-, MRP4- and MRP5-mediated transport from intact cells with high affinity.	Quercetin	11-20	ATP binding cassette subfamily C member 5	Homo sapiens	74-78
16156793-10	2005	Collectively, these results suggest that dietary flavonoids such as quercetin and silymarin can modulate transport activities of MRP1, -4 and -5.	Quercetin	68-77	ATP binding cassette subfamily C member 1	Homo sapiens	129-144
15905060-13	2005	The validated method was applied to quantify quercetin, kaempferol and isorhamnetin in human breast cancer Bcap37 and Bcap37/MDR1 cells.	Quercetin	45-54	prohibitin 2	Homo sapiens	107-113
15905060-13	2005	The validated method was applied to quantify quercetin, kaempferol and isorhamnetin in human breast cancer Bcap37 and Bcap37/MDR1 cells.	Quercetin	45-54	prohibitin 2	Homo sapiens	118-124
15905060-13	2005	The validated method was applied to quantify quercetin, kaempferol and isorhamnetin in human breast cancer Bcap37 and Bcap37/MDR1 cells.	Quercetin	45-54	ATP binding cassette subfamily B member 1	Homo sapiens	125-129
16222869-6	2005	Melatonin, sodium selenite, NAC and quercetin greatly promoted the lymphocytes proliferation to IL-2.	Quercetin	36-45	interleukin 2	Homo sapiens	96-100
16023337-6	2005	Apigenin and quercetin only inhibited aromatase/17beta-HSD at high doses as did genistein, biochanin A and daidzein.	Quercetin	13-22	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	38-47
16132362-6	2005	In human colon epithelial cells, the effect of quercetin on tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor kappa B (NFkappaB) activation was examined.	Quercetin	47-56	tumor necrosis factor	Homo sapiens	89-98
16132362-6	2005	In human colon epithelial cells, the effect of quercetin on tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor kappa B (NFkappaB) activation was examined.	Quercetin	47-56	nuclear factor kappa B subunit 1	Homo sapiens	108-130
16132362-6	2005	In human colon epithelial cells, the effect of quercetin on tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor kappa B (NFkappaB) activation was examined.	Quercetin	47-56	nuclear factor kappa B subunit 1	Homo sapiens	132-140
16132362-9	2005	Furthermore, quercetin dose-dependently inhibited an inflammatory signal TNF-alpha-dependent NFkappaB activation.	Quercetin	13-22	tumor necrosis factor	Rattus norvegicus	73-82
16132362-9	2005	Furthermore, quercetin dose-dependently inhibited an inflammatory signal TNF-alpha-dependent NFkappaB activation.	Quercetin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	93-101
16132362-10	2005	CONCLUSIONS: Our data suggest that rutin acted as a quercetin deliverer to the large intestine and its anti-inflammatory action in TNBS-induced colitis rats may be through quercetin-mediated inhibition of TNF-alpha-induced NFkappaB activation.	Quercetin	172-181	tumor necrosis factor	Rattus norvegicus	205-214
16132362-10	2005	CONCLUSIONS: Our data suggest that rutin acted as a quercetin deliverer to the large intestine and its anti-inflammatory action in TNBS-induced colitis rats may be through quercetin-mediated inhibition of TNF-alpha-induced NFkappaB activation.	Quercetin	172-181	nuclear factor kappa B subunit 1	Homo sapiens	223-231
15951572-5	2005	Molecular surface comparisons of YhhW and Pirin with structurally similar proteins suggested quercetin as a potential ligand.	Quercetin	93-102	pirin	Homo sapiens	42-47
15912140-6	2005	Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin.	Quercetin	74-83	interleukin 6	Homo sapiens	11-15
15912140-6	2005	Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin.	Quercetin	74-83	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
15912140-6	2005	Release of IL-6, IL-8 and TNF-alpha was inhibited by 82-93% at 100 microM quercetin and kaempferol, and 31-70% by myricetin and morin.	Quercetin	74-83	tumor necrosis factor	Homo sapiens	26-35
16132362-6	2005	In human colon epithelial cells, the effect of quercetin on tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor kappa B (NFkappaB) activation was examined.	Quercetin	47-56	tumor necrosis factor	Homo sapiens	60-87
15998352-0	2005	Activity of NADPH-cytochrome P-450 reductase of the human heart, liver and lungs in the presence of (-)-epigallocatechin gallate, quercetin and resveratrol: an in vitro study.	Quercetin	130-139	cytochrome p450 oxidoreductase	Homo sapiens	12-44
16027405-1	2005	Previous in vitro studies have demonstrated that quercetin inhibits CYP2C8, but there are no available data to indicate that quercetin inhibits CYP2C8 in vivo.	Quercetin	49-58	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	68-74
16027405-1	2005	Previous in vitro studies have demonstrated that quercetin inhibits CYP2C8, but there are no available data to indicate that quercetin inhibits CYP2C8 in vivo.	Quercetin	125-134	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	144-150
16023337-6	2005	Apigenin and quercetin only inhibited aromatase/17beta-HSD at high doses as did genistein, biochanin A and daidzein.	Quercetin	13-22	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	48-58
15942332-13	2005	An inhibitor of HSP expression, quercetin, was utilized to assess role of HSP expression in prevention of sepsis-related mortality.	Quercetin	32-41	selenoprotein K	Rattus norvegicus	16-19
15937998-0	2005	The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor.	Quercetin	41-50	estrogen receptor 1	Homo sapiens	70-87
15937998-2	2005	In this study, the possible involvement of the estrogen receptor (ER) in the stimulation of cell proliferation by quercetin was investigated.	Quercetin	114-123	estrogen receptor 1	Homo sapiens	47-64
15937998-2	2005	In this study, the possible involvement of the estrogen receptor (ER) in the stimulation of cell proliferation by quercetin was investigated.	Quercetin	114-123	estrogen receptor 1	Homo sapiens	66-68
15937998-4	2005	Quercetin stimulated proliferation of ER-positive cells only, suggesting this effect to be ER-dependent.	Quercetin	0-9	estrogen receptor 1	Homo sapiens	38-40
15937998-4	2005	Quercetin stimulated proliferation of ER-positive cells only, suggesting this effect to be ER-dependent.	Quercetin	0-9	estrogen receptor 1	Homo sapiens	91-93
15937998-5	2005	In support of these results, quercetin induced ER-ERE-mediated gene expression in a reporter gene assay using U2-OS cells transfected with either ERalpha or ERbeta, with 10(5)-10(6) times lower affinity than 17beta-estradiol (E2) and 10(2)-10(3 )times lower affinity than genistein.	Quercetin	29-38	estrogen receptor 1	Homo sapiens	47-49
15937998-5	2005	In support of these results, quercetin induced ER-ERE-mediated gene expression in a reporter gene assay using U2-OS cells transfected with either ERalpha or ERbeta, with 10(5)-10(6) times lower affinity than 17beta-estradiol (E2) and 10(2)-10(3 )times lower affinity than genistein.	Quercetin	29-38	estrogen receptor 1	Homo sapiens	146-153
15937998-5	2005	In support of these results, quercetin induced ER-ERE-mediated gene expression in a reporter gene assay using U2-OS cells transfected with either ERalpha or ERbeta, with 10(5)-10(6) times lower affinity than 17beta-estradiol (E2) and 10(2)-10(3 )times lower affinity than genistein.	Quercetin	29-38	estrogen receptor 2	Homo sapiens	157-163
15937998-6	2005	Quercetin activated the ERbeta to a 4.5-fold higher level than E2, whereas the maximum induction level of ERalpha by quercetin was only 1.7 fold that of E2.	Quercetin	0-9	estrogen receptor 2	Homo sapiens	24-30
15937998-6	2005	Quercetin activated the ERbeta to a 4.5-fold higher level than E2, whereas the maximum induction level of ERalpha by quercetin was only 1.7 fold that of E2.	Quercetin	117-126	estrogen receptor 1	Homo sapiens	106-113
15937998-7	2005	These results point at the relatively high capacity of quercetin to stimulate supposed "beneficial" ERbeta responses as compared to the stimulation of ERalpha, the receptor possibly involved in adverse cell proliferative effects.	Quercetin	55-64	estrogen receptor 2	Homo sapiens	100-106
15925552-8	2005	This assay was used to determine both parent quercetin and the quercetin after enzymatic hydrolysis with beta-glucuronidase/sulfatase in human plasma and urine samples following the ingestion of quercetin 500 mg capsules.	Quercetin	63-72	arylsulfatase family member H	Homo sapiens	124-133
15925552-8	2005	This assay was used to determine both parent quercetin and the quercetin after enzymatic hydrolysis with beta-glucuronidase/sulfatase in human plasma and urine samples following the ingestion of quercetin 500 mg capsules.	Quercetin	63-72	arylsulfatase family member H	Homo sapiens	124-133
16156274-0	2005	[Effects of quercetin and enalapril on amount of PDGF-B and VEGF-1 in kidney of diabetic rats].	Quercetin	12-21	platelet derived growth factor subunit B	Rattus norvegicus	49-55
16156274-9	2005	The protective role of Quercetin and Enalapril in lowering urinary protein excretion may be related to the decreased amounts of PDGF-B and VEGF-1 in renal tissue.	Quercetin	23-32	platelet derived growth factor subunit B	Rattus norvegicus	128-134
15876423-0	2005	Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages.	Quercetin	0-9	heme oxygenase 1	Homo sapiens	108-124
15942332-18	2005	Administration of the HSP inhibitor quercetin blocked GLN-mediated enhancement of HSP expression and abrogated GLN"s survival benefit.	Quercetin	36-45	selenoprotein K	Rattus norvegicus	22-25
15942332-18	2005	Administration of the HSP inhibitor quercetin blocked GLN-mediated enhancement of HSP expression and abrogated GLN"s survival benefit.	Quercetin	36-45	selenoprotein K	Rattus norvegicus	82-85
15911222-6	2005	However, the investigated flavonoids did show potency to inhibit OCT-mediated transport (IC50-values: quercetin&lt;kaempferol&lt;&lt;naringenin&lt;isoquercitrin&lt;spiraeoside&lt;&lt;rutin&lt;hesperetin&lt;naringin).	Quercetin	102-111	plexin A2	Homo sapiens	65-68
15829497-6	2005	When MCF-7 cells were stimulated with resveratrol, quercetin or genistein, there was an increase in PTEN protein levels.	Quercetin	51-60	phosphatase and tensin homolog	Homo sapiens	100-104
16149735-5	2005	Physiological concentrations of catechin and quercetin offered similar levels of protection against modification by carbonyls of the apoB-100 at advanced stages (carbonyls approximately 96.0 nmol/mg LDL protein) but not at the intermediate stages (carbonyls approximately 58.0 nmol/mg LDL protein) of LDL oxidation probably owing to differences in the protein-binding mechanisms of catechin and quercetin.	Quercetin	45-54	apolipoprotein B	Homo sapiens	133-141
15930438-0	2005	Quercetin attenuates nuclear factor-kappaB activation and nitric oxide production in interleukin-1beta-activated rat hepatocytes.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	85-102
15882264-13	2005	The induction of Hsp70 was blocked by quercetin.	Quercetin	38-47	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	17-22
15882264-18	2005	Quercetin, an inhibitor of Hsp70 induction, eliminated these renoprotective effects of GGA.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	27-32
15914627-12	2005	Quercetin decreased MG132-induced expression of HSP27, -70, and -90 by more than 70%, and heat shock factors HSF2 and -4 by more than 65%.	Quercetin	0-9	heat shock protein 1	Mus musculus	48-53
15914627-13	2005	Quercetin pretreatment significantly reversed the decrease in caspase-1, -6, and -8 activities and the antiapoptotic effect of MG132 on IFN-gamma-treated LECs.	Quercetin	0-9	caspase 1	Mus musculus	62-83
15914627-13	2005	Quercetin pretreatment significantly reversed the decrease in caspase-1, -6, and -8 activities and the antiapoptotic effect of MG132 on IFN-gamma-treated LECs.	Quercetin	0-9	interferon gamma	Mus musculus	136-145
15930438-1	2005	We investigated whether different concentrations of the flavonoid quercetin ameliorate nitric oxide production and nuclear factor (NF)-kappaB activation in interleukin (IL)-1beta-activated rat hepatocytes.	Quercetin	66-75	interleukin 1 beta	Rattus norvegicus	156-178
15930438-4	2005	Quercetin at 100 micromol/L significantly prevented the IL-1beta-induced release of nitrite into the culture medium.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	56-64
15930438-5	2005	Western blot and reverse transcription-PCR analyses demonstrated that increased levels of inducible nitric oxide synthase (iNOS) protein and mRNA in hepatocytes stimulated by IL-1beta were prevented by 50 micromol/L and 100 micromol/L of quercetin.	Quercetin	238-247	nitric oxide synthase 2	Rattus norvegicus	90-121
15930438-5	2005	Western blot and reverse transcription-PCR analyses demonstrated that increased levels of inducible nitric oxide synthase (iNOS) protein and mRNA in hepatocytes stimulated by IL-1beta were prevented by 50 micromol/L and 100 micromol/L of quercetin.	Quercetin	238-247	nitric oxide synthase 2	Rattus norvegicus	123-127
15930438-5	2005	Western blot and reverse transcription-PCR analyses demonstrated that increased levels of inducible nitric oxide synthase (iNOS) protein and mRNA in hepatocytes stimulated by IL-1beta were prevented by 50 micromol/L and 100 micromol/L of quercetin.	Quercetin	238-247	interleukin 1 beta	Rattus norvegicus	175-183
15930438-6	2005	Electrophoretic mobility shift assay experiments and Western blots indicated that quercetin blocked the activation of NF-kappaB and decreased the inhibitor kappaB protein levels induced by IL-1beta.	Quercetin	82-91	interleukin 1 beta	Rattus norvegicus	189-197
15930438-7	2005	In summary, quercetin, a natural flavonol widely distributed in the human diet, inhibits NO production in IL-1beta-stimulated hepatocytes through the inhibition of iNOS expression.	Quercetin	12-21	interleukin 1 beta	Homo sapiens	106-114
15930438-7	2005	In summary, quercetin, a natural flavonol widely distributed in the human diet, inhibits NO production in IL-1beta-stimulated hepatocytes through the inhibition of iNOS expression.	Quercetin	12-21	nitric oxide synthase 2	Homo sapiens	164-168
16149735-5	2005	Physiological concentrations of catechin and quercetin offered similar levels of protection against modification by carbonyls of the apoB-100 at advanced stages (carbonyls approximately 96.0 nmol/mg LDL protein) but not at the intermediate stages (carbonyls approximately 58.0 nmol/mg LDL protein) of LDL oxidation probably owing to differences in the protein-binding mechanisms of catechin and quercetin.	Quercetin	395-404	apolipoprotein B	Homo sapiens	133-141
16117892-4	2005	RESULTS: Compared with HL-60/S, 20-40 micromol/L quercetin in vitro remarkably enhanced the sensitivity of HL-60/ADM cells to daunorubicin, down-regulated the expression of MRP(1) gene and its protein product MRP(1), restored the abnormal subcellular distribution of daunorubicin, so as to reverse MDR.	Quercetin	49-58	ATP binding cassette subfamily C member 1	Homo sapiens	173-179
15749994-0	2005	Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides.	Quercetin	79-88	ATP binding cassette subfamily G member 2	Rattus norvegicus	34-39
15749994-0	2005	Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides.	Quercetin	79-88	ATP binding cassette subfamily G member 2	Rattus norvegicus	40-45
15749994-6	2005	In these MDCKII cells, we showed an efficient efflux-directed transport of quercetin by mouse Bcrp1, whereas in control and MRP2-transfected cells no vectorial transport of quercetin was observed.	Quercetin	75-84	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	94-99
15749994-8	2005	When intestinal Bcrp1 was inhibited by FTC in Mrp2-deficient rats, total plasma concentrations of quercetin and its methylated metabolite isorhamnetin after 30 min of perfusion were more than twice that of controls (12.3 +/- 1.5 versus 5.6 +/- 1.3 muM; p &lt; 0.01), whereas uptake of free quercetin from the intestinal lumen was not affected.	Quercetin	98-107	ATP binding cassette subfamily G member 2	Rattus norvegicus	16-21
15749994-8	2005	When intestinal Bcrp1 was inhibited by FTC in Mrp2-deficient rats, total plasma concentrations of quercetin and its methylated metabolite isorhamnetin after 30 min of perfusion were more than twice that of controls (12.3 +/- 1.5 versus 5.6 +/- 1.3 muM; p &lt; 0.01), whereas uptake of free quercetin from the intestinal lumen was not affected.	Quercetin	98-107	fucosyltransferase 2	Rattus norvegicus	39-42
15749994-8	2005	When intestinal Bcrp1 was inhibited by FTC in Mrp2-deficient rats, total plasma concentrations of quercetin and its methylated metabolite isorhamnetin after 30 min of perfusion were more than twice that of controls (12.3 +/- 1.5 versus 5.6 +/- 1.3 muM; p &lt; 0.01), whereas uptake of free quercetin from the intestinal lumen was not affected.	Quercetin	290-299	ATP binding cassette subfamily G member 2	Rattus norvegicus	16-21
15749994-10	2005	In conclusion, Bcrp1 limits net intestinal absorption of quercetin by pumping quercetin glucuronides back into the lumen.	Quercetin	57-66	ATP binding cassette subfamily G member 2	Rattus norvegicus	15-20
16117892-4	2005	RESULTS: Compared with HL-60/S, 20-40 micromol/L quercetin in vitro remarkably enhanced the sensitivity of HL-60/ADM cells to daunorubicin, down-regulated the expression of MRP(1) gene and its protein product MRP(1), restored the abnormal subcellular distribution of daunorubicin, so as to reverse MDR.	Quercetin	49-58	ATP binding cassette subfamily C member 1	Homo sapiens	209-215
15884859-0	2005	Covalent binding of the flavonoid quercetin to human serum albumin.	Quercetin	34-43	albumin	Homo sapiens	53-66
15884859-4	2005	The binding of quercetin to human serum albumin (HSA) in human blood and the effect of stimulation of neutrophilic myeloperoxidase on this binding were also measured.	Quercetin	15-24	albumin	Homo sapiens	34-47
16158939-4	2005	MiaPaCa-2 cells, treated with luteolin (Lu) and quercetin (Qu), were used to dampen FAK phosphorylation and protein expression by parallel suppression of cell migration ability.	Quercetin	48-57	protein tyrosine kinase 2	Homo sapiens	84-87
16158939-7	2005	Our results show that FAK functions as a key regulator of cell migration, and that FAK activity can be suppressed by specific FAK siRNA, and by luteolin and quercetin.	Quercetin	157-166	protein tyrosine kinase 2	Homo sapiens	22-25
16158939-7	2005	Our results show that FAK functions as a key regulator of cell migration, and that FAK activity can be suppressed by specific FAK siRNA, and by luteolin and quercetin.	Quercetin	157-166	protein tyrosine kinase 2	Homo sapiens	83-86
16158939-7	2005	Our results show that FAK functions as a key regulator of cell migration, and that FAK activity can be suppressed by specific FAK siRNA, and by luteolin and quercetin.	Quercetin	157-166	protein tyrosine kinase 2	Homo sapiens	83-86
15974445-6	2005	Furthermore, catechin, epigallocatechin gallate (EGCG), epicatechin (EC), luteolin, chrysin, quercetin, and galangin increased IL-2 secretion while EGC, apigenin, and fisetin inhibited the secretion.	Quercetin	93-102	interleukin 2	Homo sapiens	127-131
15826605-8	2005	Preincubation of cells with quercetin followed by cisplatin treatment appeared to be the most effective and was correlated with strong activation of caspase-3 and inhibition of both heat shock proteins (Hsp72) and multi-drug resistance proteins (MRP) levels.	Quercetin	28-37	caspase 3	Homo sapiens	149-158
15975156-10	2005	The down-regulation of Bcl-2 and up-regulation of caspase-3 activation were reversed by the cytoprotective flavonoids, (-)-epigallocatechin gallate, quercetin and hesperetin, at &gt;/=10 microm.	Quercetin	149-158	BCL2 apoptosis regulator	Homo sapiens	23-28
15975156-10	2005	The down-regulation of Bcl-2 and up-regulation of caspase-3 activation were reversed by the cytoprotective flavonoids, (-)-epigallocatechin gallate, quercetin and hesperetin, at &gt;/=10 microm.	Quercetin	149-158	caspase 3	Homo sapiens	50-59
15778020-4	2005	Glutathione concentration and glutathione reductase activity was significantly (p &lt; 0.05) decreased with quercetin treatment, while no such effect was observed with daidzein treatment.	Quercetin	108-117	glutathione-disulfide reductase	Rattus norvegicus	30-51
15778020-5	2005	Interestingly, decrease in glutathione concentration and glutathione reductase activity by quercetin treatment was inhibited by combined administration of daidzein and quercetin.	Quercetin	91-100	glutathione-disulfide reductase	Rattus norvegicus	57-78
15778020-5	2005	Interestingly, decrease in glutathione concentration and glutathione reductase activity by quercetin treatment was inhibited by combined administration of daidzein and quercetin.	Quercetin	168-177	glutathione-disulfide reductase	Rattus norvegicus	57-78
15778020-7	2005	These results suggest that quercetin, but not daidzein, acts as a pro-oxidant agent by decreasing glutathione concentration and glutathione reductase activity.	Quercetin	27-36	glutathione-disulfide reductase	Rattus norvegicus	128-149
15661808-0	2005	Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cells.	Quercetin	43-52	androgen receptor	Homo sapiens	87-104
15661808-3	2005	Our previous study has shown that quercetin, one of the main polyphenols, can effectively inhibit the expression and function of the AR.	Quercetin	34-43	androgen receptor	Homo sapiens	133-135
15661808-4	2005	The present study is to address if quercetin may affect Sp1"s action on AR transactivation activity in human prostate adenocarcinoma cell lines, LNCaP and PC-3.	Quercetin	35-44	androgen receptor	Homo sapiens	72-74
15661808-8	2005	However, the state of interaction of Sp1 with the AR treated by quercetin plus androgen was different from that by androgen treatment or none as demonstrated by coimmunoprecipitation experiments and glutathione S-transferase (GST) pull-down assays.	Quercetin	64-73	androgen receptor	Homo sapiens	50-52
15661808-9	2005	Moreover, we showed that quercetin caused changes in post-translational modification of AR protein.	Quercetin	25-34	androgen receptor	Homo sapiens	88-90
15661808-10	2005	The above findings strongly suggest that changes induced by quercetin in post-translational modification of the AR and in states of physical interaction of Sp1 with the AR may be critical for the attenuation of AR"s function.	Quercetin	60-69	androgen receptor	Homo sapiens	112-114
15661808-10	2005	The above findings strongly suggest that changes induced by quercetin in post-translational modification of the AR and in states of physical interaction of Sp1 with the AR may be critical for the attenuation of AR"s function.	Quercetin	60-69	androgen receptor	Homo sapiens	169-171
15661808-10	2005	The above findings strongly suggest that changes induced by quercetin in post-translational modification of the AR and in states of physical interaction of Sp1 with the AR may be critical for the attenuation of AR"s function.	Quercetin	60-69	androgen receptor	Homo sapiens	169-171
15877109-14	2005	However, myocardial fructose levels were significantly decreased in the rutin- and quercetin-treated animals compared with the vehicle-treated animals, possibly owing to their aldose reductase inhibitory activity.	Quercetin	83-92	aldo-keto reductase family 1 member B1	Rattus norvegicus	176-192
15795422-9	2005	Caspase-3 activity was enhanced by H2O2, and this increase was inhibited by (-)epigallocatechin gallate and quercetin.	Quercetin	108-117	caspase 3	Homo sapiens	0-9
15795422-1	2005	We reported recently that (-)epigallocatechin gallate and quercetin inhibited H2O2-induced apoptosis through modulation of the expression of apoptosis-related Bcl-2 and Bax in endothelial cells.	Quercetin	58-67	BCL2 apoptosis regulator	Homo sapiens	159-164
15795422-11	2005	Western blot data revealed that H2O2 upregulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which was rapidly reversed by quercetin within 30 min; H2O2 activation of c-Jun was downregulated.	Quercetin	177-186	mitogen-activated protein kinase 8	Homo sapiens	68-91
15795422-1	2005	We reported recently that (-)epigallocatechin gallate and quercetin inhibited H2O2-induced apoptosis through modulation of the expression of apoptosis-related Bcl-2 and Bax in endothelial cells.	Quercetin	58-67	BCL2 associated X, apoptosis regulator	Homo sapiens	169-172
15795422-6	2005	Micromolar (-)epigallocatechin gallate and quercetin partially eliminated the dichlorodihydrofluorescein (DCF) and phospho-p53 staining, suggesting that these flavonoids inhibited the accumulation of intracellular oxidants and nuclear transactivation of p53 in H2O2-exposed cells.	Quercetin	43-52	tumor protein p53	Homo sapiens	123-126
15795422-6	2005	Micromolar (-)epigallocatechin gallate and quercetin partially eliminated the dichlorodihydrofluorescein (DCF) and phospho-p53 staining, suggesting that these flavonoids inhibited the accumulation of intracellular oxidants and nuclear transactivation of p53 in H2O2-exposed cells.	Quercetin	43-52	tumor protein p53	Homo sapiens	254-257
15795422-11	2005	Western blot data revealed that H2O2 upregulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which was rapidly reversed by quercetin within 30 min; H2O2 activation of c-Jun was downregulated.	Quercetin	177-186	mitogen-activated protein kinase 8	Homo sapiens	93-96
15795422-11	2005	Western blot data revealed that H2O2 upregulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which was rapidly reversed by quercetin within 30 min; H2O2 activation of c-Jun was downregulated.	Quercetin	177-186	mitogen-activated protein kinase 14	Homo sapiens	102-138
15795422-11	2005	Western blot data revealed that H2O2 upregulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which was rapidly reversed by quercetin within 30 min; H2O2 activation of c-Jun was downregulated.	Quercetin	177-186	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-73
15795422-13	2005	These results reveal that quercetin blocks JNK- and p38 MAPK-related signaling triggered by the oxidant and may regulate expression of apoptotic downstream genes, preventing apoptosis and promoting cell survival.	Quercetin	26-35	mitogen-activated protein kinase 8	Homo sapiens	43-46
15670774-0	2005	Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells.	Quercetin	0-9	catenin beta 1	Homo sapiens	38-50
15670774-0	2005	Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells.	Quercetin	0-9	hepatocyte nuclear factor 4 alpha	Homo sapiens	51-54
15670774-2	2005	We examined the effect of quercetin, a famous anti-tumor agent, against beta-catenin/Tcf signaling in SW480 cells.	Quercetin	26-35	catenin beta 1	Homo sapiens	72-84
15670774-2	2005	We examined the effect of quercetin, a famous anti-tumor agent, against beta-catenin/Tcf signaling in SW480 cells.	Quercetin	26-35	hepatocyte nuclear factor 4 alpha	Homo sapiens	85-88
15670774-3	2005	Quercetin inhibited the transcriptional activity of beta-catenin/Tcf in SW480 and also in HEK293 cells transiently transfected with constitutively active mutant beta-catenin gene, whose product is not induced to be degraded by APC-Axin-GSK3beta complex, so we concluded that its inhibitory mechanism was related to beta-catenin itself or downstream components.	Quercetin	0-9	catenin beta 1	Homo sapiens	52-64
15670774-3	2005	Quercetin inhibited the transcriptional activity of beta-catenin/Tcf in SW480 and also in HEK293 cells transiently transfected with constitutively active mutant beta-catenin gene, whose product is not induced to be degraded by APC-Axin-GSK3beta complex, so we concluded that its inhibitory mechanism was related to beta-catenin itself or downstream components.	Quercetin	0-9	hepatocyte nuclear factor 4 alpha	Homo sapiens	65-68
15670774-3	2005	Quercetin inhibited the transcriptional activity of beta-catenin/Tcf in SW480 and also in HEK293 cells transiently transfected with constitutively active mutant beta-catenin gene, whose product is not induced to be degraded by APC-Axin-GSK3beta complex, so we concluded that its inhibitory mechanism was related to beta-catenin itself or downstream components.	Quercetin	0-9	catenin beta 1	Homo sapiens	161-173
15670774-3	2005	Quercetin inhibited the transcriptional activity of beta-catenin/Tcf in SW480 and also in HEK293 cells transiently transfected with constitutively active mutant beta-catenin gene, whose product is not induced to be degraded by APC-Axin-GSK3beta complex, so we concluded that its inhibitory mechanism was related to beta-catenin itself or downstream components.	Quercetin	0-9	catenin beta 1	Homo sapiens	161-173
15670774-4	2005	To investigate the precise inhibitory mechanism, we performed EMSA showing that binding of the Tcf complexes to its specific DNA-binding sites was strongly suppressed by quercetin.	Quercetin	170-179	hepatocyte nuclear factor 4 alpha	Homo sapiens	95-98
15670774-5	2005	Immunoprecipitation analysis also showed that the binding of beta-catenin to Tcf-4 was also disrupted by quercetin.	Quercetin	105-114	catenin beta 1	Homo sapiens	61-73
15670774-5	2005	Immunoprecipitation analysis also showed that the binding of beta-catenin to Tcf-4 was also disrupted by quercetin.	Quercetin	105-114	transcription factor 4	Homo sapiens	77-82
15670774-6	2005	Western blot analysis proved these decreased bindings resulted from decreased level of beta-catenin and Tcf-4 product in nucleus caused by quercetin.	Quercetin	139-148	catenin beta 1	Homo sapiens	87-99
15670774-6	2005	Western blot analysis proved these decreased bindings resulted from decreased level of beta-catenin and Tcf-4 product in nucleus caused by quercetin.	Quercetin	139-148	transcription factor 4	Homo sapiens	104-109
15670774-7	2005	Together, we suggest that quercetin is an excellent inhibitor of beta-catenin/Tcf signaling in SW480 cell lines, and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4 proteins.	Quercetin	26-35	catenin beta 1	Homo sapiens	65-77
15670774-7	2005	Together, we suggest that quercetin is an excellent inhibitor of beta-catenin/Tcf signaling in SW480 cell lines, and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4 proteins.	Quercetin	26-35	hepatocyte nuclear factor 4 alpha	Homo sapiens	78-81
15670774-7	2005	Together, we suggest that quercetin is an excellent inhibitor of beta-catenin/Tcf signaling in SW480 cell lines, and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4 proteins.	Quercetin	26-35	transcription factor 4	Homo sapiens	220-225
15688188-10	2005	Moreover, rutin reduced RANK protein, whereas 17beta-oestradiol and quercetin promoted apoptosis by cleavage of caspase-8 and caspase-3.	Quercetin	68-77	caspase 8	Homo sapiens	112-121
15619261-2	2005	Quinidine (a specific inhibitor of CYP2D6) did not markedly affect the metabolism of perospirone, whereas quercetin (an inhibitor of CYP2C8) and ketoconazole (an inhibitor of CYP3A4) caused a decrease in the metabolism with human liver microsomes in a concentration dependent fashion.	Quercetin	106-115	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	133-139
15538571-16	2005	Quercetin dose-dependently inhibited the expression of PKC-alpha but not that of PKC-beta and PKC-delta.	Quercetin	0-9	protein kinase C, alpha	Mus musculus	55-64
15538571-17	2005	Doxorubicin almost completely blocked the effect of quercetin on the expression of PKC-alpha.	Quercetin	52-61	protein kinase C, alpha	Mus musculus	83-92
15538571-18	2005	Quercetin was also involved in the translocation of PKC-delta from the cytosol to the nucleus.	Quercetin	0-9	protein kinase C, delta	Mus musculus	52-61
15538571-19	2005	PMA enhanced the effect of quercetin on the translocation of PKC-delta.	Quercetin	27-36	protein kinase C, delta	Mus musculus	61-70
15538571-20	2005	CONCLUSIONS: These results indicate that quercetin induced apoptosis of murine melanoma B16-BL6 cells by injuring their mitochondria, increasing the activity of caspase-3, inhibiting the expression of Bcl-2 and PKC-alpha, and inducing the translocation of PKC-delta.	Quercetin	41-50	caspase 3	Mus musculus	161-170
15538571-20	2005	CONCLUSIONS: These results indicate that quercetin induced apoptosis of murine melanoma B16-BL6 cells by injuring their mitochondria, increasing the activity of caspase-3, inhibiting the expression of Bcl-2 and PKC-alpha, and inducing the translocation of PKC-delta.	Quercetin	41-50	B cell leukemia/lymphoma 2	Mus musculus	201-206
15538571-20	2005	CONCLUSIONS: These results indicate that quercetin induced apoptosis of murine melanoma B16-BL6 cells by injuring their mitochondria, increasing the activity of caspase-3, inhibiting the expression of Bcl-2 and PKC-alpha, and inducing the translocation of PKC-delta.	Quercetin	41-50	protein kinase C, alpha	Mus musculus	211-220
15538571-20	2005	CONCLUSIONS: These results indicate that quercetin induced apoptosis of murine melanoma B16-BL6 cells by injuring their mitochondria, increasing the activity of caspase-3, inhibiting the expression of Bcl-2 and PKC-alpha, and inducing the translocation of PKC-delta.	Quercetin	41-50	protein kinase C, delta	Mus musculus	256-265
15538571-21	2005	Doxorubicin inhibited these effects of quercetin by blocking the decreased expression of PKC-alpha induced by quercetin while PMA increased these effects by enhancing the translocation of PKC-delta induced by quercetin.	Quercetin	39-48	protein kinase C, alpha	Mus musculus	89-98
15538571-21	2005	Doxorubicin inhibited these effects of quercetin by blocking the decreased expression of PKC-alpha induced by quercetin while PMA increased these effects by enhancing the translocation of PKC-delta induced by quercetin.	Quercetin	39-48	protein kinase C, delta	Mus musculus	188-197
15538571-21	2005	Doxorubicin inhibited these effects of quercetin by blocking the decreased expression of PKC-alpha induced by quercetin while PMA increased these effects by enhancing the translocation of PKC-delta induced by quercetin.	Quercetin	110-119	protein kinase C, alpha	Mus musculus	89-98
15538571-21	2005	Doxorubicin inhibited these effects of quercetin by blocking the decreased expression of PKC-alpha induced by quercetin while PMA increased these effects by enhancing the translocation of PKC-delta induced by quercetin.	Quercetin	110-119	protein kinase C, alpha	Mus musculus	89-98
15538571-0	2005	Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-alpha and translocating PKC-delta.	Quercetin	54-63	protein kinase C, alpha	Mus musculus	113-122
15538571-0	2005	Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-alpha and translocating PKC-delta.	Quercetin	54-63	protein kinase C, delta	Mus musculus	141-150
15538571-9	2005	Phorbol 12-myristate 13-acetate (PMA), a PKC activator, significantly enhanced apoptosis induced by quercetin, while doxorubicin, a PKC inhibitor, markedly decreased it.	Quercetin	100-109	peroneal muscular atrophy	Mus musculus	0-37
15538571-9	2005	Phorbol 12-myristate 13-acetate (PMA), a PKC activator, significantly enhanced apoptosis induced by quercetin, while doxorubicin, a PKC inhibitor, markedly decreased it.	Quercetin	100-109	protein kinase C, alpha	Mus musculus	41-44
15538571-12	2005	Moreover, PMA showed reinforcement, while doxorubicin showed significant antagonization, of the quercetin-mediated decrease in the expression of Bcl-2.	Quercetin	96-105	B cell leukemia/lymphoma 2	Mus musculus	145-150
15538571-13	2005	Quercetin promoted caspase-3 activity in a dose-dependent manner, which was also regulated by PMA and doxorubicin with a pattern similar to that seen in their effect on apoptosis, mitochondrial membrane potential and Bcl-2 expression, but none of these were directly affected by PMA and doxorubicin.	Quercetin	0-9	caspase 3	Mus musculus	19-28
15538571-13	2005	Quercetin promoted caspase-3 activity in a dose-dependent manner, which was also regulated by PMA and doxorubicin with a pattern similar to that seen in their effect on apoptosis, mitochondrial membrane potential and Bcl-2 expression, but none of these were directly affected by PMA and doxorubicin.	Quercetin	0-9	B cell leukemia/lymphoma 2	Mus musculus	217-222
15688188-10	2005	Moreover, rutin reduced RANK protein, whereas 17beta-oestradiol and quercetin promoted apoptosis by cleavage of caspase-8 and caspase-3.	Quercetin	68-77	caspase 3	Homo sapiens	126-135
15735102-0	2005	Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro.	Quercetin	39-48	tumor protein p53	Homo sapiens	66-69
15608134-5	2005	The P-glycoprotein activator quercetin (10-100 microM) enhanced rhodamine 123 CL(bile) by approximately 4-fold, with only a minor effect on BEI, suggesting that quercetin had a more pronounced effect on uptake at the basolateral membrane rather than excretion across the canalicular membrane.	Quercetin	29-38	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	4-18
15309432-8	2005	RESULTS: Quercetin (5 microM) downregulated expression of cell cycle genes (for example CDC6, CDK4 and cyclin D1), downregulated cell proliferation and induced cell cycle arrest in Caco-2 cells.	Quercetin	9-18	cell division cycle 6	Homo sapiens	88-92
15309432-8	2005	RESULTS: Quercetin (5 microM) downregulated expression of cell cycle genes (for example CDC6, CDK4 and cyclin D1), downregulated cell proliferation and induced cell cycle arrest in Caco-2 cells.	Quercetin	9-18	cyclin dependent kinase 4	Homo sapiens	94-98
15309432-8	2005	RESULTS: Quercetin (5 microM) downregulated expression of cell cycle genes (for example CDC6, CDK4 and cyclin D1), downregulated cell proliferation and induced cell cycle arrest in Caco-2 cells.	Quercetin	9-18	cyclin D1	Homo sapiens	103-112
15309432-11	2005	In addition, genes involved in signal transduction pathways like beta catenin/TCF signalling and MAPK signal transduction were influenced by quercetin.	Quercetin	141-150	catenin beta 1	Homo sapiens	65-77
15309432-11	2005	In addition, genes involved in signal transduction pathways like beta catenin/TCF signalling and MAPK signal transduction were influenced by quercetin.	Quercetin	141-150	hepatocyte nuclear factor 4 alpha	Homo sapiens	78-81
15741050-0	2005	Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells.	Quercetin	0-9	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-43
15741050-0	2005	Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells.	Quercetin	0-9	erb-b2 receptor tyrosine kinase 3	Homo sapiens	48-53
15741050-3	2005	In this study, we assessed quercetin regulation of HT-29 and SW480 cell apoptosis and the influence of quercetin on the protein expression of ErbB2, ErbB3, Akt, Bax and Bcl-2.	Quercetin	103-112	erb-b2 receptor tyrosine kinase 2	Homo sapiens	142-147
15741050-3	2005	In this study, we assessed quercetin regulation of HT-29 and SW480 cell apoptosis and the influence of quercetin on the protein expression of ErbB2, ErbB3, Akt, Bax and Bcl-2.	Quercetin	103-112	erb-b2 receptor tyrosine kinase 3	Homo sapiens	149-154
15741050-3	2005	In this study, we assessed quercetin regulation of HT-29 and SW480 cell apoptosis and the influence of quercetin on the protein expression of ErbB2, ErbB3, Akt, Bax and Bcl-2.	Quercetin	103-112	AKT serine/threonine kinase 1	Homo sapiens	156-159
15741050-3	2005	In this study, we assessed quercetin regulation of HT-29 and SW480 cell apoptosis and the influence of quercetin on the protein expression of ErbB2, ErbB3, Akt, Bax and Bcl-2.	Quercetin	103-112	BCL2 associated X, apoptosis regulator	Homo sapiens	161-164
15741050-3	2005	In this study, we assessed quercetin regulation of HT-29 and SW480 cell apoptosis and the influence of quercetin on the protein expression of ErbB2, ErbB3, Akt, Bax and Bcl-2.	Quercetin	103-112	BCL2 apoptosis regulator	Homo sapiens	169-174
15741050-7	2005	Western blot analysis of cell lysates revealed that Bcl-2 levels decreased dose-dependently in cells treated with quercetin, but Bax remained unchanged.	Quercetin	114-123	BCL2 apoptosis regulator	Homo sapiens	52-57
15741050-9	2005	In addition, phosphorylated Akt levels were markedly lower in cells treated with 25 micromol/L quercetin, but total Akt levels decreased only at 100 micromol/L quercetin.	Quercetin	95-104	AKT serine/threonine kinase 1	Homo sapiens	28-31
15741050-9	2005	In addition, phosphorylated Akt levels were markedly lower in cells treated with 25 micromol/L quercetin, but total Akt levels decreased only at 100 micromol/L quercetin.	Quercetin	160-169	AKT serine/threonine kinase 1	Homo sapiens	116-119
15735102-0	2005	Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro.	Quercetin	39-48	cyclin dependent kinase inhibitor 1A	Homo sapiens	52-64
15741050-10	2005	Furthermore, a dose-dependent decrease in ErbB2 and ErbB3 levels was detected in quercetin-treated cells.	Quercetin	81-90	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-47
15735102-4	2005	We found that quercetin and combinations of quercetin and ellagic acid nonsynergistically increased p53 protein levels.	Quercetin	14-23	tumor protein p53	Homo sapiens	100-103
15741050-10	2005	Furthermore, a dose-dependent decrease in ErbB2 and ErbB3 levels was detected in quercetin-treated cells.	Quercetin	81-90	erb-b2 receptor tyrosine kinase 3	Homo sapiens	52-57
15741050-12	2005	In conclusion, we have shown that quercetin inhibits cell growth and induces apoptosis in colon cancer cells, and that this may be mediated by its ability to down-regulate ErbB2/ErbB3 signaling and the Akt pathway.	Quercetin	34-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	172-177
15735102-4	2005	We found that quercetin and combinations of quercetin and ellagic acid nonsynergistically increased p53 protein levels.	Quercetin	44-53	tumor protein p53	Homo sapiens	100-103
15741050-12	2005	In conclusion, we have shown that quercetin inhibits cell growth and induces apoptosis in colon cancer cells, and that this may be mediated by its ability to down-regulate ErbB2/ErbB3 signaling and the Akt pathway.	Quercetin	34-43	erb-b2 receptor tyrosine kinase 3	Homo sapiens	178-183
15741050-12	2005	In conclusion, we have shown that quercetin inhibits cell growth and induces apoptosis in colon cancer cells, and that this may be mediated by its ability to down-regulate ErbB2/ErbB3 signaling and the Akt pathway.	Quercetin	34-43	AKT serine/threonine kinase 1	Homo sapiens	202-205
15735102-5	2005	In contrast, ellagic acid potentiated the effects of quercetin for p21(cip1/waf1) protein levels and p53 phosphorylation at serine 15, possibly explaining the synergistic effect observed in apoptosis induction.	Quercetin	53-62	cyclin dependent kinase inhibitor 1A	Homo sapiens	67-70
15735102-5	2005	In contrast, ellagic acid potentiated the effects of quercetin for p21(cip1/waf1) protein levels and p53 phosphorylation at serine 15, possibly explaining the synergistic effect observed in apoptosis induction.	Quercetin	53-62	cyclin dependent kinase inhibitor 1A	Homo sapiens	71-75
15735102-5	2005	In contrast, ellagic acid potentiated the effects of quercetin for p21(cip1/waf1) protein levels and p53 phosphorylation at serine 15, possibly explaining the synergistic effect observed in apoptosis induction.	Quercetin	53-62	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-80
15735102-6	2005	Phosphorylation of the mitogen-activated protein (MAP) kinases, c-jun N-terminal (JNK)1,2 and p38, was also increased by the combination of ellagic acid and quercetin, whereas quercetin alone induced only p38.	Quercetin	157-166	mitogen-activated protein kinase 8	Homo sapiens	64-87
15735102-6	2005	Phosphorylation of the mitogen-activated protein (MAP) kinases, c-jun N-terminal (JNK)1,2 and p38, was also increased by the combination of ellagic acid and quercetin, whereas quercetin alone induced only p38.	Quercetin	157-166	mitogen-activated protein kinase 14	Homo sapiens	94-97
15735102-6	2005	Phosphorylation of the mitogen-activated protein (MAP) kinases, c-jun N-terminal (JNK)1,2 and p38, was also increased by the combination of ellagic acid and quercetin, whereas quercetin alone induced only p38.	Quercetin	157-166	mitogen-activated protein kinase 14	Homo sapiens	205-208
15735102-10	2005	In summary, quercetin and ellagic acid combined increase the activation of p53 and p21(cip1/waf1) and the MAP kinases, JNK1,2 and p38, in a more than additive manner, suggesting a mechanism by which quercetin and ellagic acid synergistically induce apoptosis in cancer cells.	Quercetin	12-21	tumor protein p53	Homo sapiens	75-78
15735102-10	2005	In summary, quercetin and ellagic acid combined increase the activation of p53 and p21(cip1/waf1) and the MAP kinases, JNK1,2 and p38, in a more than additive manner, suggesting a mechanism by which quercetin and ellagic acid synergistically induce apoptosis in cancer cells.	Quercetin	12-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	83-86
15735102-10	2005	In summary, quercetin and ellagic acid combined increase the activation of p53 and p21(cip1/waf1) and the MAP kinases, JNK1,2 and p38, in a more than additive manner, suggesting a mechanism by which quercetin and ellagic acid synergistically induce apoptosis in cancer cells.	Quercetin	12-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	87-91
15735102-10	2005	In summary, quercetin and ellagic acid combined increase the activation of p53 and p21(cip1/waf1) and the MAP kinases, JNK1,2 and p38, in a more than additive manner, suggesting a mechanism by which quercetin and ellagic acid synergistically induce apoptosis in cancer cells.	Quercetin	12-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	92-96
15735102-10	2005	In summary, quercetin and ellagic acid combined increase the activation of p53 and p21(cip1/waf1) and the MAP kinases, JNK1,2 and p38, in a more than additive manner, suggesting a mechanism by which quercetin and ellagic acid synergistically induce apoptosis in cancer cells.	Quercetin	12-21	mitogen-activated protein kinase 8	Homo sapiens	119-123
15735102-10	2005	In summary, quercetin and ellagic acid combined increase the activation of p53 and p21(cip1/waf1) and the MAP kinases, JNK1,2 and p38, in a more than additive manner, suggesting a mechanism by which quercetin and ellagic acid synergistically induce apoptosis in cancer cells.	Quercetin	12-21	mitogen-activated protein kinase 14	Homo sapiens	130-133
16128280-10	2005	The results of our study showed: 1) the decrease in PMN oxidant production in patient during the mass reduction, 2) the strong antioxidant activity of quercetin and rutin in obese patients before and during the body mass reduction, these effects were dose dependent and rutin was less potent than quercetin, 3) acceleration of PMN apoptosis by rutin is associated with an increase in caspase 3 activity.	Quercetin	151-160	caspase 3	Homo sapiens	384-393
15770537-5	2005	Quercetin also inhibited procaspase-3 activation to caspase-3 in HeLa cells induced by HP VacA toxin, which may induce cell death via the proteolytic activation of a cascade of caspases.	Quercetin	0-9	caspase 3	Homo sapiens	25-37
15770537-5	2005	Quercetin also inhibited procaspase-3 activation to caspase-3 in HeLa cells induced by HP VacA toxin, which may induce cell death via the proteolytic activation of a cascade of caspases.	Quercetin	0-9	caspase 3	Homo sapiens	28-37
15740983-6	2005	The flavonol quercetin inhibited eNOS expression (with no effect on eNOS promoter activity).	Quercetin	13-22	nitric oxide synthase 3	Homo sapiens	33-37
15664304-0	2005	Effect of Cleome arabica leaf extract, rutin and quercetin on soybean lipoxygenase activity and on generation of inflammatory eicosanoids by human neutrophils.	Quercetin	49-58	linoleate 9S-lipoxygenase-4	Glycine max	70-82
15664304-6	2005	The extract, rutin and quercetin caused concentration-dependent inhibition of soybean Lox activity.	Quercetin	23-32	linoleate 9S-lipoxygenase-4	Glycine max	86-89
15664304-7	2005	These results indicate that rutin, quercetin and an extract of C. arabica containing these compounds inhibit Lox activity, consequently decreasing LTB4 production.	Quercetin	35-44	linoleate 9S-lipoxygenase-4	Glycine max	109-112
15670891-7	2005	An isobolographic analysis was performed to assess the apparent synergistic interaction for the combinations of ellagic acid with resveratrol and quercetin with resveratrol in the induction of caspase 3 activity, confirming a synergistic interaction with a combination index of 0.64 for the combination of ellagic acid and resveratrol and 0.68 for quercetin and resveratrol.	Quercetin	146-155	caspase 3	Homo sapiens	193-202
15760569-0	2005	[Effect of quercetin on the activities of cytochrome p450 1A1 in L-02 cell lines and human liver microsomes].	Quercetin	11-20	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	42-61
15670891-7	2005	An isobolographic analysis was performed to assess the apparent synergistic interaction for the combinations of ellagic acid with resveratrol and quercetin with resveratrol in the induction of caspase 3 activity, confirming a synergistic interaction with a combination index of 0.64 for the combination of ellagic acid and resveratrol and 0.68 for quercetin and resveratrol.	Quercetin	348-357	caspase 3	Homo sapiens	193-202
15684479-8	2005	Further, the incorporation of apigenin, 3-hydroxyflavone, luteolin, and quercetin, which are more toxic, into TIG-1 cells during 24-h incubation was examined.	Quercetin	72-81	retinoic acid receptor responder 1	Homo sapiens	110-115
15789741-1	2005	The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARgamma) are reported.	Quercetin	84-94	peroxisome proliferator activated receptor gamma	Homo sapiens	110-158
15789741-1	2005	The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARgamma) are reported.	Quercetin	84-94	peroxisome proliferator activated receptor gamma	Homo sapiens	160-169
15689157-8	2005	However, CDK2 and HCK kinase in complex with other flavone inhibitors such as quercetin and flavopiridol showed a different binding mode with the inhibitor rotated by about 180 degrees.	Quercetin	78-87	cyclin dependent kinase 2	Homo sapiens	9-13
15689157-8	2005	However, CDK2 and HCK kinase in complex with other flavone inhibitors such as quercetin and flavopiridol showed a different binding mode with the inhibitor rotated by about 180 degrees.	Quercetin	78-87	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-21
15665974-4	2005	The species resulting from the interaction of quercetin with proteins, when concentrated at the H2O/CCl4 interface, generate enhanced BSL signals characterized at 376.0 nm which were found to be proportional to human serum albumin (HSA) and bovine serum albumin (BSA) in the range of 1-1250 ng mL(-1) and 2-1250 ng mL(-1), respectively.	Quercetin	46-55	albumin	Homo sapiens	217-230
15665974-4	2005	The species resulting from the interaction of quercetin with proteins, when concentrated at the H2O/CCl4 interface, generate enhanced BSL signals characterized at 376.0 nm which were found to be proportional to human serum albumin (HSA) and bovine serum albumin (BSA) in the range of 1-1250 ng mL(-1) and 2-1250 ng mL(-1), respectively.	Quercetin	46-55	albumin	Homo sapiens	248-261
15723751-9	2005	The next two groups of rats were treated with quercetin (HSP-70 inhibitor; 400 mg/kg intraperitoneally) 6 h before LPS administration.	Quercetin	46-55	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	57-63
15828450-0	2005	Inhibition of P-glycoprotein function and expression by kaempferol and quercetin.	Quercetin	71-80	ATP binding cassette subfamily B member 1	Homo sapiens	14-28
15828450-2	2005	This study demonstrates that some putative flavonoids, i.e., flavonols (quercetin and kaempferol) and isoflavones (genistein and daidzein) markedly increase the sensitivity of the multidrug-resistant human cervical carcinoma KB-V1 cells (high Pgp expression) to vinblastine and paclitaxel dose-dependently, and also decrease the relative resistance of these anti-cancer-drugs in KB-V1 cells.	Quercetin	72-81	ATP binding cassette subfamily B member 1	Homo sapiens	243-246
15670828-4	2005	DT-diaphorase (NQO1) might protect against QQ toxicity by reducing QQ to quercetin.	Quercetin	73-82	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-13
15670828-4	2005	DT-diaphorase (NQO1) might protect against QQ toxicity by reducing QQ to quercetin.	Quercetin	73-82	NAD(P)H quinone dehydrogenase 1	Homo sapiens	15-19
15723751-16	2005	Quercetin inhibited a GLN-mediated increase in lung HSP-70 and blocked a beneficial effect of GLN on the ratio of adenosine triphosphate to adenosine diphosphate after LPS.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	52-58
15631523-1	2005	The interaction between four flavonoids (catechin, epicatechin, rutin, and quercetin) and bovine serum albumin (BSA) was investigated using tryptophan fluorescence quenching.	Quercetin	75-84	albumin	Homo sapiens	97-116
15596293-9	2005	A pre-treatment with the antioxidant quercetin 1 h before N-diethylnitrosamine initiation, significantly prevented development of gamma-glutamyl transpeptidase-positive lesions.	Quercetin	37-46	gamma-glutamyltransferase 1	Rattus norvegicus	130-159
15631523-5	2005	Quercetin has a total quenching effect on BSA tryptophan fluorescence at a molar ratio of 10:1 and rutin at approximately 25:1.	Quercetin	0-9	albumin	Homo sapiens	42-45
15502008-8	2005	Other effective UGT1A8 substrates (&gt;0.1 nmol/mg/min) included 9-OH-benzo[a]pyrene, 1-naphthol, 4-methylumbelliferone, 7-hydroxycoumarin, chrysin, quercetin, 4-nitrophenol, and estriol.	Quercetin	149-158	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	16-22
15644141-0	2005	In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer.	Quercetin	61-70	lactase	Homo sapiens	23-30
15644141-7	2005	Treatment with lactase increased quercetin recovery from the shallot digestate nearly 10-fold and decreased quercetin-4"-glucoside recovery by more than 100-fold (p &lt; 0.05), but had no effect on quercetin recovery from apple digestates.	Quercetin	33-42	lactase	Homo sapiens	15-22
15644141-7	2005	Treatment with lactase increased quercetin recovery from the shallot digestate nearly 10-fold and decreased quercetin-4"-glucoside recovery by more than 100-fold (p &lt; 0.05), but had no effect on quercetin recovery from apple digestates.	Quercetin	108-117	lactase	Homo sapiens	15-22
15644141-8	2005	Lactase treatment also increased shallot quercetin bioavailability to the Caco-2 cells approximately 14-fold, and decreased shallot quercetin-4"-glucoside bioavailability 23-fold (p &lt; 0.05).	Quercetin	41-50	lactase	Homo sapiens	0-7
15644141-10	2005	CONCLUSIONS: The increase in quercetin uptake following treatment with lactase suggests that dietary supplementation with lactase may increase quercetin bioavailability in lactose intolerant humans.	Quercetin	29-38	lactase	Homo sapiens	71-78
15644141-10	2005	CONCLUSIONS: The increase in quercetin uptake following treatment with lactase suggests that dietary supplementation with lactase may increase quercetin bioavailability in lactose intolerant humans.	Quercetin	29-38	lactase	Homo sapiens	122-129
15644141-10	2005	CONCLUSIONS: The increase in quercetin uptake following treatment with lactase suggests that dietary supplementation with lactase may increase quercetin bioavailability in lactose intolerant humans.	Quercetin	143-152	lactase	Homo sapiens	71-78
15644141-10	2005	CONCLUSIONS: The increase in quercetin uptake following treatment with lactase suggests that dietary supplementation with lactase may increase quercetin bioavailability in lactose intolerant humans.	Quercetin	143-152	lactase	Homo sapiens	122-129
15618000-0	2005	CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin.	Quercetin	69-78	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
15618000-1	2005	Epidemiological studies suggest that food rich in quercetin and naringin may protect against certain types of lung cancer, and that genotype dependent inhibition of cytochrome P450 1A1 (CYP1A1)-mediated bioactivation of procarcinogens could be the underlying mechanism.	Quercetin	50-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	165-184
15618000-1	2005	Epidemiological studies suggest that food rich in quercetin and naringin may protect against certain types of lung cancer, and that genotype dependent inhibition of cytochrome P450 1A1 (CYP1A1)-mediated bioactivation of procarcinogens could be the underlying mechanism.	Quercetin	50-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	186-192
15618000-4	2005	Quercetin potently inhibited diolepoxide 2 formation by all CYP1A1 types with IC(50) values between 1.6 and 7.0 microM.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	60-66
15618000-6	2005	Enzyme kinetics revealed quercetin as a mixed-type inhibitor of CYP1A1.1, CYP1A1.2, and CYP1A1.4 with K(i) values of 2.0, 6.4, and 9.3 microM, respectively.	Quercetin	25-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70
15618000-6	2005	Enzyme kinetics revealed quercetin as a mixed-type inhibitor of CYP1A1.1, CYP1A1.2, and CYP1A1.4 with K(i) values of 2.0, 6.4, and 9.3 microM, respectively.	Quercetin	25-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	74-80
15618000-6	2005	Enzyme kinetics revealed quercetin as a mixed-type inhibitor of CYP1A1.1, CYP1A1.2, and CYP1A1.4 with K(i) values of 2.0, 6.4, and 9.3 microM, respectively.	Quercetin	25-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	74-80
15618000-8	2005	Our data support the hypothesis that quercetin may have a stronger chemopreventive effect in individuals carrying wild-type compared with variant CYP1A1 genes.	Quercetin	37-46	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	146-152
15507517-9	2005	OR486 and quercetin (COMT inhibitor) blocked the conversion of 2-hydroxyestradiol to 2-methoxyestradiol in CFs.	Quercetin	10-19	catechol-O-methyltransferase	Homo sapiens	21-25
16201310-0	2005	Quercetin suppresses heat shock-induced nuclear translocation of Hsp72.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1A	Homo sapiens	65-70
16201310-1	2005	The effect of quercetin and heat shock on the Hsp72 level and distribution in HeLa cells was studied by Western blotting, indirect immunofluorescence and immunogold electron microscopy.	Quercetin	14-23	heat shock protein family A (Hsp70) member 1A	Homo sapiens	46-51
16201310-2	2005	In control cells and after quercetin treatment, Hsp72 was located both in the cytoplasm and in the nucleus in comparable amounts.	Quercetin	27-36	heat shock protein family A (Hsp70) member 1A	Homo sapiens	48-53
16201310-5	2005	Preincubation of heated cells with quercetin inhibited strong Hsp72 expression observed after hyperthermia and changed the intracellular Hsp72 distribution.	Quercetin	35-44	heat shock protein family A (Hsp70) member 1A	Homo sapiens	62-67
16201310-5	2005	Preincubation of heated cells with quercetin inhibited strong Hsp72 expression observed after hyperthermia and changed the intracellular Hsp72 distribution.	Quercetin	35-44	heat shock protein family A (Hsp70) member 1A	Homo sapiens	137-142
16201310-8	2005	Our results indicate that pro-apoptotic activity of quercetin may be correlated not only with the inhibition of Hsp72 expression but also with suppression of its migration to the nucleus.	Quercetin	52-61	heat shock protein family A (Hsp70) member 1A	Homo sapiens	112-117
15922113-4	2005	Interestingly, flavonoids with chemopreventative effects, such as quercetin, genistein, and epigallocatechin gallate activate ATM.	Quercetin	66-75	ataxia telangiectasia mutated	Mus musculus	126-129
15611226-7	2005	Moreover, we demonstrate that chemotherapeutic agents that suppress protein synthesis and reverse the CD40-mediated dissociation of the translational repressor eukaryotic initiation factor 4E-binding protein from the initiation factor eukaryotic initiation factor 4E, such as 5-fluorouracil, etoposide, and quercetin, dramatically increase the susceptibility of cervical carcinoma cells to CD40L-induced apoptosis.	Quercetin	307-316	CD40 molecule	Homo sapiens	102-106
15611226-7	2005	Moreover, we demonstrate that chemotherapeutic agents that suppress protein synthesis and reverse the CD40-mediated dissociation of the translational repressor eukaryotic initiation factor 4E-binding protein from the initiation factor eukaryotic initiation factor 4E, such as 5-fluorouracil, etoposide, and quercetin, dramatically increase the susceptibility of cervical carcinoma cells to CD40L-induced apoptosis.	Quercetin	307-316	eukaryotic translation initiation factor 4E	Homo sapiens	160-191
15611226-7	2005	Moreover, we demonstrate that chemotherapeutic agents that suppress protein synthesis and reverse the CD40-mediated dissociation of the translational repressor eukaryotic initiation factor 4E-binding protein from the initiation factor eukaryotic initiation factor 4E, such as 5-fluorouracil, etoposide, and quercetin, dramatically increase the susceptibility of cervical carcinoma cells to CD40L-induced apoptosis.	Quercetin	307-316	eukaryotic translation initiation factor 4E	Homo sapiens	235-266
16059641-2	2005	In presented study treatments of human leukemia cells HL60 and their MDR-1 resistant subline HL60/VCR by flavonoids apigenin (API), luteolin (LUT), quercetin (QU) and anticancer drug doxorubicin (DOX) are reported.	Quercetin	148-157	ATP binding cassette subfamily B member 1	Homo sapiens	69-74
15694690-6	2005	Iron chelators (desferal, quercetin, and apoferritin) also increase A-T cell genomic stability and viability, and activate ATM-dependent cellular events in normal cells.	Quercetin	26-35	ataxia telangiectasia mutated	Mus musculus	123-126
15694690-9	2005	Support for this hypothesis comes from the recent observation that the iron chelating flavonoid quercetin both directly activates ATM and protects neuronal cells from the toxic effects of the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.	Quercetin	96-105	ataxia telangiectasia mutated	Mus musculus	130-133
15694690-10	2005	Therefore since; (1) ATM is required for iron toxicity resistance, (2) iron chelators such as quercetin, desferal, and apoferritin induce ATM activity and/or ATM-dependent events, and (3), Atm-deficient mice preferentially lose dopaminergic nigro-striatal neurons, we propose that ATM activity has an important function in PD.	Quercetin	94-103	ataxia telangiectasia mutated	Mus musculus	21-24
15694690-10	2005	Therefore since; (1) ATM is required for iron toxicity resistance, (2) iron chelators such as quercetin, desferal, and apoferritin induce ATM activity and/or ATM-dependent events, and (3), Atm-deficient mice preferentially lose dopaminergic nigro-striatal neurons, we propose that ATM activity has an important function in PD.	Quercetin	94-103	ataxia telangiectasia mutated	Mus musculus	138-141
15694690-10	2005	Therefore since; (1) ATM is required for iron toxicity resistance, (2) iron chelators such as quercetin, desferal, and apoferritin induce ATM activity and/or ATM-dependent events, and (3), Atm-deficient mice preferentially lose dopaminergic nigro-striatal neurons, we propose that ATM activity has an important function in PD.	Quercetin	94-103	ataxia telangiectasia mutated	Mus musculus	138-141
15694690-10	2005	Therefore since; (1) ATM is required for iron toxicity resistance, (2) iron chelators such as quercetin, desferal, and apoferritin induce ATM activity and/or ATM-dependent events, and (3), Atm-deficient mice preferentially lose dopaminergic nigro-striatal neurons, we propose that ATM activity has an important function in PD.	Quercetin	94-103	ataxia telangiectasia mutated	Mus musculus	189-192
15694690-10	2005	Therefore since; (1) ATM is required for iron toxicity resistance, (2) iron chelators such as quercetin, desferal, and apoferritin induce ATM activity and/or ATM-dependent events, and (3), Atm-deficient mice preferentially lose dopaminergic nigro-striatal neurons, we propose that ATM activity has an important function in PD.	Quercetin	94-103	ataxia telangiectasia mutated	Mus musculus	138-141
16573383-7	2005	Thymidylate synthase (TS), a key S-phase enzyme, was inhibited in a time- and dose-dependent fashion by quercetin at the protein level.	Quercetin	104-113	thymidylate synthetase	Homo sapiens	0-20
16573383-7	2005	Thymidylate synthase (TS), a key S-phase enzyme, was inhibited in a time- and dose-dependent fashion by quercetin at the protein level.	Quercetin	104-113	thymidylate synthetase	Homo sapiens	22-24
16573383-10	2005	Prolonged exposure of the surviving cells to quercetin causes apoptosis, presumably mediated by inhibition of TS protein.	Quercetin	45-54	thymidylate synthetase	Homo sapiens	110-112
15580028-0	2004	Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars.	Quercetin	95-104	transforming growth factor beta 1	Homo sapiens	15-46
15644950-3	2004	In this study, the effects of quercetin on mitochondrial membrane potential (DeltaPsim) change as well as quercetin"s ability to induce apoptosis and inhibit Pgp-mediated efflux of 99mTc-MIBI in K562/adr cells were investigated.	Quercetin	106-115	phosphoglycolate phosphatase	Homo sapiens	158-161
15764345-6	2004	Depletion of HSP70 by two independent strategies, either with anti-sense oligonucleotides directed against HSP70 mRNA or with the bioflavinoid drug quercetin, led to apoptosis in the absence of stress.	Quercetin	148-157	heat shock protein family A (Hsp70) member 4	Homo sapiens	13-18
15386501-4	2004	Glucuronic and sulfate forms of quercetin in plasma were hydrolyzed enzymatically using beta-glucuronidase and sulfatase, respectively.	Quercetin	32-41	arylsulfatase family member H	Homo sapiens	111-120
15456784-0	2004	Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells.	Quercetin	26-35	tumor protein p53	Homo sapiens	13-16
15456784-2	2004	However, the regulation of survivin and p53 on the quercetin-induced cell growth inhibition and apoptosis in cancer cells remains unclear.	Quercetin	51-60	tumor protein p53	Homo sapiens	40-43
15456784-3	2004	In this study, we investigated the roles of survivin and p53 in the quercetin-treated human lung carcinoma cells.	Quercetin	68-77	tumor protein p53	Homo sapiens	57-60
15456784-5	2004	Additionally, quercetin inhibited the cell growth, increased the fractions of G(2)/M phase, and raised the levels of cyclin B1 and phospho-cdc2 (threonine 161) proteins.	Quercetin	14-23	cyclin B1	Homo sapiens	117-126
15456784-5	2004	Additionally, quercetin inhibited the cell growth, increased the fractions of G(2)/M phase, and raised the levels of cyclin B1 and phospho-cdc2 (threonine 161) proteins.	Quercetin	14-23	cyclin dependent kinase 1	Homo sapiens	139-143
15456784-9	2004	Subsequently, quercetin increased the levels of total p53 (DO-1), phospho-p53 (serine 15), and p21 proteins, which were translocated to the nuclei in A549 cells.	Quercetin	14-23	tumor protein p53	Homo sapiens	54-57
15456784-9	2004	Subsequently, quercetin increased the levels of total p53 (DO-1), phospho-p53 (serine 15), and p21 proteins, which were translocated to the nuclei in A549 cells.	Quercetin	14-23	tumor protein p53	Homo sapiens	74-77
15456784-9	2004	Subsequently, quercetin increased the levels of total p53 (DO-1), phospho-p53 (serine 15), and p21 proteins, which were translocated to the nuclei in A549 cells.	Quercetin	14-23	H3 histone pseudogene 16	Homo sapiens	95-98
15456784-10	2004	Treatment with a specific p53 inhibitor, pifithrin-alpha, or transfection of a p53 antisense oligodeoxynucleotide enhanced the cytotoxicity of the quercetin-treated cells.	Quercetin	147-156	tumor protein p53	Homo sapiens	26-29
15456784-10	2004	Treatment with a specific p53 inhibitor, pifithrin-alpha, or transfection of a p53 antisense oligodeoxynucleotide enhanced the cytotoxicity of the quercetin-treated cells.	Quercetin	147-156	tumor protein p53	Homo sapiens	79-82
15456784-11	2004	Furthermore, transfection of a small interfering RNA of p21 enhanced the quercetin-induced cell death in A549 cells.	Quercetin	73-82	H3 histone pseudogene 16	Homo sapiens	56-59
15456784-12	2004	Together, our results suggest that survivin can reduce the cell growth inhibition and apoptosis, and p53 elevates the p21 level, which may attenuate the cell death in the quercetin-treated human lung carcinoma cells.	Quercetin	171-180	tumor protein p53	Homo sapiens	101-104
15456784-12	2004	Together, our results suggest that survivin can reduce the cell growth inhibition and apoptosis, and p53 elevates the p21 level, which may attenuate the cell death in the quercetin-treated human lung carcinoma cells.	Quercetin	171-180	H3 histone pseudogene 16	Homo sapiens	118-121
15476665-9	2004	IkappaB decrease and induction of iNOS protein were partially prevented by quercetin.	Quercetin	75-84	nitric oxide synthase 2	Rattus norvegicus	34-38
15465339-3	2004	The physicochemical results were in accordance to establish the compounds hydroxylated on C-6 and C-7 positions as the most active of the series with antioxidant potencies comparable to those of quercetin and vitamin C.	Quercetin	195-204	complement C6	Homo sapiens	90-93
15465339-3	2004	The physicochemical results were in accordance to establish the compounds hydroxylated on C-6 and C-7 positions as the most active of the series with antioxidant potencies comparable to those of quercetin and vitamin C.	Quercetin	195-204	complement C7	Homo sapiens	98-101
15580028-4	2004	Quercetin also blocks the signal transduction of insulin-like growth factor-1 in keloid fibroblasts.	Quercetin	0-9	insulin like growth factor 1	Homo sapiens	49-77
15580028-5	2004	This study assessed the effects of quercetin on the transforming growth factor (TGF)-beta/Smad-signaling pathway in keloid-derived fibroblasts, which may be an important biologic mechanism of this proliferative scarring.	Quercetin	35-44	transforming growth factor beta 1	Homo sapiens	80-89
15580028-8	2004	RESULTS: Quercetin significantly inhibited the expression of TGF-beta receptors 1 and 2 in keloid fibroblasts at three concentrations (low, medium, and high).	Quercetin	9-18	transforming growth factor beta 1	Homo sapiens	61-69
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 2	Homo sapiens	59-64
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 3	Homo sapiens	66-71
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 4	Homo sapiens	77-82
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 2	Homo sapiens	117-122
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 3	Homo sapiens	127-132
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 2	Homo sapiens	117-122
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 3	Homo sapiens	127-132
15580028-9	2004	Quercetin also strongly suppressed the basal expression of Smad2, Smad3, and Smad4 as well as the phosphorylation of Smad2 and Smad3 and the formation of the Smad2-Smad3-Smad4 complex.	Quercetin	0-9	SMAD family member 4	Homo sapiens	170-175
15580028-10	2004	CONCLUSIONS: Taken together, these data suggest that quercetin effectively blocks the TGF-beta/Smad-signaling pathway in keloid fibroblasts.	Quercetin	53-62	transforming growth factor beta 1	Homo sapiens	86-94
15573758-0	2004	[Effect of quercetin on the signal pathway of TGFbeta1 in activated hepatic stellate cells].	Quercetin	11-20	transforming growth factor, beta 1	Rattus norvegicus	46-54
15573758-1	2004	OBJECTIVE: To investigate the effect of quercetin on the expression of connective tissue growth factor (CTGF) and fibronectin (FN) in hepatic stellate cells (HSCs) stimulated with transforming growth factor (TGF)beta1.	Quercetin	40-49	cellular communication network factor 2	Rattus norvegicus	71-102
15573758-1	2004	OBJECTIVE: To investigate the effect of quercetin on the expression of connective tissue growth factor (CTGF) and fibronectin (FN) in hepatic stellate cells (HSCs) stimulated with transforming growth factor (TGF)beta1.	Quercetin	40-49	cellular communication network factor 2	Rattus norvegicus	104-108
15573758-1	2004	OBJECTIVE: To investigate the effect of quercetin on the expression of connective tissue growth factor (CTGF) and fibronectin (FN) in hepatic stellate cells (HSCs) stimulated with transforming growth factor (TGF)beta1.	Quercetin	40-49	fibronectin 1	Rattus norvegicus	114-125
15573758-1	2004	OBJECTIVE: To investigate the effect of quercetin on the expression of connective tissue growth factor (CTGF) and fibronectin (FN) in hepatic stellate cells (HSCs) stimulated with transforming growth factor (TGF)beta1.	Quercetin	40-49	fibronectin 1	Rattus norvegicus	127-129
15573758-4	2004	RESULTS: Quercetin (10(-8) to 10(-5) mol/L) inhibited the expression of TGFbeta1 in HSCs.	Quercetin	9-18	transforming growth factor, beta 1	Rattus norvegicus	72-80
15573758-5	2004	TGFbeta1 expression decreased after the HSCs being incubated with quercetin (10(-7) mol/L) for 48 h (mean fluorescence: 13.33+/-2.44 and 18.08+/-2.54, t=16.52, P&lt;0.01).	Quercetin	66-75	transforming growth factor, beta 1	Rattus norvegicus	0-8
15573758-6	2004	TGFbeta1 increased the expression of CTGF mRNA in HSCs, but this effect was abrogated by quercetin (10(-7) mol/L) within 72 h. Quercetin (10(-7) mol/L) significantly inhibited the expression of FN in HSCs.	Quercetin	89-98	transforming growth factor, beta 1	Rattus norvegicus	0-8
15573758-6	2004	TGFbeta1 increased the expression of CTGF mRNA in HSCs, but this effect was abrogated by quercetin (10(-7) mol/L) within 72 h. Quercetin (10(-7) mol/L) significantly inhibited the expression of FN in HSCs.	Quercetin	127-136	transforming growth factor, beta 1	Rattus norvegicus	0-8
15573758-6	2004	TGFbeta1 increased the expression of CTGF mRNA in HSCs, but this effect was abrogated by quercetin (10(-7) mol/L) within 72 h. Quercetin (10(-7) mol/L) significantly inhibited the expression of FN in HSCs.	Quercetin	127-136	cellular communication network factor 2	Rattus norvegicus	37-41
15573758-7	2004	CONCLUSION: Quercetin may have an inhibitory effect on the signal pathways of TGFbeta1, including the expression of TGFbeta1, FN and CTGF.	Quercetin	12-21	transforming growth factor, beta 1	Rattus norvegicus	78-86
15573758-7	2004	CONCLUSION: Quercetin may have an inhibitory effect on the signal pathways of TGFbeta1, including the expression of TGFbeta1, FN and CTGF.	Quercetin	12-21	transforming growth factor, beta 1	Rattus norvegicus	116-124
15573758-7	2004	CONCLUSION: Quercetin may have an inhibitory effect on the signal pathways of TGFbeta1, including the expression of TGFbeta1, FN and CTGF.	Quercetin	12-21	fibronectin 1	Rattus norvegicus	126-128
15573758-7	2004	CONCLUSION: Quercetin may have an inhibitory effect on the signal pathways of TGFbeta1, including the expression of TGFbeta1, FN and CTGF.	Quercetin	12-21	cellular communication network factor 2	Rattus norvegicus	133-137
15155531-9	2004	COX-2 mRNA expression was suppressed by quercetin and the synthetic COX-2 inhibitors in a time- and dose-dependent manner.	Quercetin	40-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
15180920-4	2004	Resveratrol and the related molecule quercetin, but not deoxyrhapontin, inhibited IL-8 and granulocyte-macrophage colony-stimulating factor release from A549 cells.	Quercetin	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	82-147
15502363-0	2004	Spectrophotometric and kinetic studies on the binding of the bioflavonoid quercetin to bovine serum albumin.	Quercetin	74-83	albumin	Homo sapiens	94-107
15502363-1	2004	This work investigates the binding of the bioflavonoid, quercetin, to bovine serum albumin (BSA) by spectrophotometric techniques involving both the conventional and stopped-flow methods.	Quercetin	56-65	albumin	Homo sapiens	77-90
15476745-6	2004	In addition, the enzyme assays showed that quercetin actively stimulated the antioxidant defense systems including superoxide dismutase, catalase, glutathione, and glutathione reductase only in the BNL CL.2 cells.	Quercetin	43-52	catalase	Mus musculus	137-145
15476745-6	2004	In addition, the enzyme assays showed that quercetin actively stimulated the antioxidant defense systems including superoxide dismutase, catalase, glutathione, and glutathione reductase only in the BNL CL.2 cells.	Quercetin	43-52	glutathione reductase	Mus musculus	164-185
15327830-0	2004	Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells.	Quercetin	35-44	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
15516026-0	2004	Phenotype-genotype relationships of SULT1A1 in human liver and variations in the IC50 of the SULT1A1 inhibitor quercetin.	Quercetin	111-120	sulfotransferase family 1A member 1	Homo sapiens	36-43
15516026-0	2004	Phenotype-genotype relationships of SULT1A1 in human liver and variations in the IC50 of the SULT1A1 inhibitor quercetin.	Quercetin	111-120	sulfotransferase family 1A member 1	Homo sapiens	93-100
15544168-6	2004	Conversely, quercetin, a recognized blocker of stress-responsive Hsp70 expression, diminished the effects caused by heat preconditioning.	Quercetin	12-21	heat shock protein 1B	Mus musculus	65-70
15365656-7	2004	LOP N-demethylation was significantly inhibited when coincubated with quercetin (a CYP2C8 inhibitor) and ketoconazole (a CYP3A4 inhibitor) by 40 and 90%, respectively, but other chemical inhibitors tested showed weak or no significant inhibition.	Quercetin	70-79	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	83-89
15365656-7	2004	LOP N-demethylation was significantly inhibited when coincubated with quercetin (a CYP2C8 inhibitor) and ketoconazole (a CYP3A4 inhibitor) by 40 and 90%, respectively, but other chemical inhibitors tested showed weak or no significant inhibition.	Quercetin	70-79	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	121-127
15327830-0	2004	Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells.	Quercetin	35-44	androgen receptor	Homo sapiens	102-119
15327830-1	2004	Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR).	Quercetin	29-38	androgen receptor	Homo sapiens	79-96
15327830-1	2004	Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR).	Quercetin	29-38	androgen receptor	Homo sapiens	98-100
15191910-5	2004	We sought to determine (i) the effect of apigenin, genistein, kaempferol, and quercetin on CFTR processing in IB3-1 cells (F508/W1282X) and (ii) whether sequential treatment with 4-phenylbutyrate (4-PBA) to increase CFTR processing and flavonoid to directly stimulate CFTR would increase Cl- conductance.	Quercetin	78-87	CF transmembrane conductance regulator	Homo sapiens	91-95
15350128-4	2004	The unique active-site pocket in QR2 could potentially bind other natural polyphenols such as flavonoids, as proven by the high affinity exhibited by quercetin toward QR2.	Quercetin	150-159	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	33-36
15350128-4	2004	The unique active-site pocket in QR2 could potentially bind other natural polyphenols such as flavonoids, as proven by the high affinity exhibited by quercetin toward QR2.	Quercetin	150-159	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	167-170
15487807-8	2004	Quercetin, a flavonoid present in edible fruit, vegetable and wine, was a potent inhibitor of human liver SULT1A1 and estrogen sulfotransferase (EST) activities and the sulfation of resveratrol.	Quercetin	0-9	sulfotransferase family 1A member 1	Homo sapiens	106-113
15665909-4	2004	The HSP70 synthesis inhibitor quercetin potentiated DNA fragmentation in macrophages cocultured with Z-VAD-FMK after heat shock.	Quercetin	30-39	heat shock protein family A (Hsp70) member 4	Homo sapiens	4-9
15288573-6	2004	Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to &lt; or =50 microM quercetin.	Quercetin	198-207	mitogen-activated protein kinase 8	Rattus norvegicus	37-60
15487807-8	2004	Quercetin, a flavonoid present in edible fruit, vegetable and wine, was a potent inhibitor of human liver SULT1A1 and estrogen sulfotransferase (EST) activities and the sulfation of resveratrol.	Quercetin	0-9	sulfotransferase family 1E member 1	Homo sapiens	118-143
15487807-10	2004	In conclusion, mefenamic acid, salicylic acid and quercetin inhibit SULT1A1 whereas SULT1A3 is relatively resistant to the inhibition by these compounds.	Quercetin	50-59	sulfotransferase family 1A member 1	Homo sapiens	68-75
15359113-5	2004	In vitro treatment of activated T cells with quercetin blocks IL-12-induced tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4, resulting in a decrease in IL-12-induced T cell proliferation and Th1 differentiation.	Quercetin	45-54	signal transducer and activator of transcription 3	Mus musculus	116-121
15359113-5	2004	In vitro treatment of activated T cells with quercetin blocks IL-12-induced tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4, resulting in a decrease in IL-12-induced T cell proliferation and Th1 differentiation.	Quercetin	45-54	signal transducer and activator of transcription 4	Mus musculus	127-132
15305212-2	2004	The existence of dihydrate and unhydrated forms of quercetin in the solid state is confirmed by several experimental techniques e.g. X-ray diffraction of powders, DSC, TGA, and NMR.	Quercetin	51-60	T-box transcription factor 1	Homo sapiens	168-171
15359113-5	2004	In vitro treatment of activated T cells with quercetin blocks IL-12-induced tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4, resulting in a decrease in IL-12-induced T cell proliferation and Th1 differentiation.	Quercetin	45-54	Janus kinase 2	Mus musculus	104-108
15359113-5	2004	In vitro treatment of activated T cells with quercetin blocks IL-12-induced tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4, resulting in a decrease in IL-12-induced T cell proliferation and Th1 differentiation.	Quercetin	45-54	tyrosine kinase 2	Mus musculus	110-114
15288573-6	2004	Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to &lt; or =50 microM quercetin.	Quercetin	198-207	mitogen-activated protein kinase 8	Rattus norvegicus	62-65
15288573-6	2004	Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to &lt; or =50 microM quercetin.	Quercetin	198-207	mitogen activated protein kinase 14	Rattus norvegicus	71-107
15288573-6	2004	Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to &lt; or =50 microM quercetin.	Quercetin	198-207	mitogen activated protein kinase 14	Rattus norvegicus	109-116
15288573-6	2004	Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to &lt; or =50 microM quercetin.	Quercetin	311-320	mitogen-activated protein kinase 8	Rattus norvegicus	37-60
15288573-6	2004	Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to &lt; or =50 microM quercetin.	Quercetin	311-320	mitogen-activated protein kinase 8	Rattus norvegicus	62-65
15288573-6	2004	Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to &lt; or =50 microM quercetin.	Quercetin	311-320	mitogen activated protein kinase 14	Rattus norvegicus	71-107
15288573-6	2004	Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to &lt; or =50 microM quercetin.	Quercetin	311-320	mitogen activated protein kinase 14	Rattus norvegicus	109-116
15169886-3	2004	In the HuH7 human hepatoma cell line, PON-1 activity and mRNA levels were increased by dietary polyphenolic compounds such as quercetin but also by toxic ligands of the aryl hydrocarbon receptor (AhR) such as 3-methylcholanthrene (3-MC).	Quercetin	126-135	MIR7-3 host gene	Homo sapiens	7-11
15658824-0	2004	[Protection of vascular endothelial cells from TNF-alpha induced injury by quercetin].	Quercetin	75-84	tumor necrosis factor	Homo sapiens	47-56
15658824-1	2004	OBJECTIVE: To investigate the effects of quercetin (Que) on the TNF-alpha injured human umbilical vein endothelial cell line (ECV-304).	Quercetin	41-50	tumor necrosis factor	Homo sapiens	64-73
15658824-1	2004	OBJECTIVE: To investigate the effects of quercetin (Que) on the TNF-alpha injured human umbilical vein endothelial cell line (ECV-304).	Quercetin	52-55	tumor necrosis factor	Homo sapiens	64-73
15658824-10	2004	CONCLUSION: These results demonstrate that Que can produce the protective action on TNF-alpha-induced cultured ECV-304 and its mechanism of action may be related to the decrease of NO, antioxidant effect of lipids.	Quercetin	43-46	tumor necrosis factor	Homo sapiens	84-93
15266218-15	2004	Hypericin, kaempferol, quercetin, and allicin inhibit the efflux and CYP3A4-mediated metabolism of xenobiotics in vitro.	Quercetin	23-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	69-75
15330498-6	2004	The same dose of the caffeic acid and quercetin was able to prevent CCl4-induced rise in serum enzymes.	Quercetin	38-47	C-C motif chemokine ligand 4	Rattus norvegicus	68-72
15090535-2	2004	Using c-fos proto-oncogene expression as an early molecular sensor of estrogen action in ERalpha-positive MCF7 and ER-negative SKBR3 breast cancer cells, we have discovered that 17beta-estradiol (E2), and the two major phytoestrogens, genistein and quercetin, stimulate c-fos expression through ERalpha as well as through an ER-independent manner via the G protein-coupled receptor homologue GPR30.	Quercetin	249-258	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	6-11
15182386-6	2004	Since the bcl-2 promoter contained two ORE, and ORE-driven transcriptional activity and Bcl-2 mRNA expression were increased by treatment with 10 microm-quercetin or kaempferol, it is possible that quercetin and kaempferol might up-regulate Bcl-2 expression through OR transactivation in MCF-7 cells.	Quercetin	153-162	BCL2 apoptosis regulator	Homo sapiens	10-15
15182386-6	2004	Since the bcl-2 promoter contained two ORE, and ORE-driven transcriptional activity and Bcl-2 mRNA expression were increased by treatment with 10 microm-quercetin or kaempferol, it is possible that quercetin and kaempferol might up-regulate Bcl-2 expression through OR transactivation in MCF-7 cells.	Quercetin	153-162	BCL2 apoptosis regulator	Homo sapiens	88-93
15182386-6	2004	Since the bcl-2 promoter contained two ORE, and ORE-driven transcriptional activity and Bcl-2 mRNA expression were increased by treatment with 10 microm-quercetin or kaempferol, it is possible that quercetin and kaempferol might up-regulate Bcl-2 expression through OR transactivation in MCF-7 cells.	Quercetin	153-162	BCL2 apoptosis regulator	Homo sapiens	241-246
15182386-6	2004	Since the bcl-2 promoter contained two ORE, and ORE-driven transcriptional activity and Bcl-2 mRNA expression were increased by treatment with 10 microm-quercetin or kaempferol, it is possible that quercetin and kaempferol might up-regulate Bcl-2 expression through OR transactivation in MCF-7 cells.	Quercetin	198-207	BCL2 apoptosis regulator	Homo sapiens	10-15
15182386-6	2004	Since the bcl-2 promoter contained two ORE, and ORE-driven transcriptional activity and Bcl-2 mRNA expression were increased by treatment with 10 microm-quercetin or kaempferol, it is possible that quercetin and kaempferol might up-regulate Bcl-2 expression through OR transactivation in MCF-7 cells.	Quercetin	198-207	BCL2 apoptosis regulator	Homo sapiens	88-93
15225597-9	2004	However, the tocopherols inhibited COX-2 activity showing that the tocopherols act post-transcriptionally on activity, whereas quercetin and some quercetin conjugates affect both the transcription and activity of COX-2.	Quercetin	127-136	prostaglandin-endoperoxide synthase 2	Homo sapiens	213-218
15225597-9	2004	However, the tocopherols inhibited COX-2 activity showing that the tocopherols act post-transcriptionally on activity, whereas quercetin and some quercetin conjugates affect both the transcription and activity of COX-2.	Quercetin	146-155	prostaglandin-endoperoxide synthase 2	Homo sapiens	213-218
15266218-6	2004	Quercetin, hypericin, and kaempferol exhibited a remarkable inhibition of P-gp-mediated efflux of ritonavir by increasing its cellular uptake in these models.	Quercetin	0-9	phosphoglycolate phosphatase	Homo sapiens	74-78
15266218-13	2004	Prolonged exposure of quercetin resulted in significant increase of mRNA expression of both MDR1 and CYP3A4 levels in Caco-2 cells.	Quercetin	22-31	ATP binding cassette subfamily B member 1	Homo sapiens	92-96
15266218-13	2004	Prolonged exposure of quercetin resulted in significant increase of mRNA expression of both MDR1 and CYP3A4 levels in Caco-2 cells.	Quercetin	22-31	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	101-107
15357005-2	2004	Therefore, the effects of vehicles and pressure-sensitive adhesives (PSA) on the in vitro permeation of quercetin across dorsal hairless mouse skin were studied.	Quercetin	104-113	aminopeptidase puromycin sensitive	Mus musculus	69-72
15357005-6	2004	The lower permeation fluxes may be due to the decrease of solubility and diffusivity of quercetin in the PSA layer, considering the fact that the highest flux of 0.26 microg/cm2/h was obtained with the addition of 0.2% butylated hydroxyanisole in PGMC-diethylene glycol monoethyl ether co-solvents (80-85 : 15-20, v/v).	Quercetin	88-97	aminopeptidase puromycin sensitive	Mus musculus	105-108
15182918-5	2004	In addition, Biota orientalis extract, quercetin and rutin, when tested in vivo on mouse liver homogenates, elicited significant inhibitory actions on the xanthine dehydrogenase/xanthine oxidase (XDH/XO) activities.	Quercetin	39-48	xanthine dehydrogenase	Mus musculus	155-177
15182918-5	2004	In addition, Biota orientalis extract, quercetin and rutin, when tested in vivo on mouse liver homogenates, elicited significant inhibitory actions on the xanthine dehydrogenase/xanthine oxidase (XDH/XO) activities.	Quercetin	39-48	xanthine dehydrogenase	Mus musculus	178-194
15330498-7	2004	Caffeic acid and quercetin also prevented the CCl4-induced prolongation in pentobarbital sleeping time confirming their hepatoprotectivity.	Quercetin	17-26	C-C motif chemokine ligand 4	Rattus norvegicus	46-50
15205707-4	2004	RESULTS: The everted gut sac study showed that quercetin significantly inhibited the function of intestinal P-glycoprotein   P-gp  .	Quercetin	47-56	phosphoglycolate phosphatase	Homo sapiens	125-129
15205707-8	2004	CONCLUSION: Quercetin can enhance acyclovir intestinal absorption by inhibiting the function of P-gp.	Quercetin	12-21	phosphoglycolate phosphatase	Homo sapiens	96-100
15169886-3	2004	In the HuH7 human hepatoma cell line, PON-1 activity and mRNA levels were increased by dietary polyphenolic compounds such as quercetin but also by toxic ligands of the aryl hydrocarbon receptor (AhR) such as 3-methylcholanthrene (3-MC).	Quercetin	126-135	paraoxonase 1	Homo sapiens	38-43
15169886-6	2004	Deletions and mutations studies showed that a xenobiotic responsive element (XRE)-like sequence within the PON-1 promoter mediated the effect of 3-MC and quercetin.	Quercetin	154-163	paraoxonase 1	Homo sapiens	107-112
15169886-7	2004	In contrast with consensus XREs from the cytochrome P450 1A1 gene, the PON-1 XRE-like element mediated preferentially the effect of quercetin compared to the results seen with TCDD.	Quercetin	132-141	paraoxonase 1	Homo sapiens	71-76
15169886-8	2004	Furthermore, AhR binding to this element was preferentially activated by quercetin.	Quercetin	73-82	aryl hydrocarbon receptor	Homo sapiens	13-16
15120627-2	2004	Quercetin produced a strong fluorescent signal upon binding to bovine serum albumin (BSA) and insulin.	Quercetin	0-9	Insulin-like receptor	Drosophila melanogaster	70-101
15118350-0	2004	Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cells.	Quercetin	48-57	heme oxygenase 1	Rattus norvegicus	13-29
15118350-3	2004	We also found that quercetin, a common polyphenolic compound in foods of plant origin, induces HO-1 expression in RAW264.7 cells.	Quercetin	19-28	heme oxygenase 1	Mus musculus	95-99
15118350-4	2004	This study was aimed at examining the potency of quercetin as a HO-1 inducer and its regulation in rat aortic smooth muscle cells (RASMCs).	Quercetin	49-58	heme oxygenase 1	Rattus norvegicus	64-68
15118350-5	2004	We showed that quercetin-induced HO-1 production was in time- and dose-dependent fashions, and that this regulation occurred at both transcription and translation levels.	Quercetin	15-24	heme oxygenase 1	Rattus norvegicus	33-37
15118350-6	2004	Quercetin increased p38 mitogen-activated protein kinase (p38MAPK), but inhibited extracellular signal-regulated kinase in RASMCs.	Quercetin	0-9	mitogen activated protein kinase 14	Rattus norvegicus	20-56
15118350-6	2004	Quercetin increased p38 mitogen-activated protein kinase (p38MAPK), but inhibited extracellular signal-regulated kinase in RASMCs.	Quercetin	0-9	mitogen activated protein kinase 14	Rattus norvegicus	58-65
15118350-7	2004	The level of quercetin-induced HO-1 expression was attenuated by SB202190 (a p38MAPK inhibitor).	Quercetin	13-22	heme oxygenase 1	Rattus norvegicus	31-35
15118350-7	2004	The level of quercetin-induced HO-1 expression was attenuated by SB202190 (a p38MAPK inhibitor).	Quercetin	13-22	mitogen activated protein kinase 14	Rattus norvegicus	77-84
15118350-8	2004	Taken together from the data in this study, we suggest that quercetin induced HO-1 expression, at least in part, through p38MAPK.	Quercetin	60-69	heme oxygenase 1	Rattus norvegicus	78-82
15118350-8	2004	Taken together from the data in this study, we suggest that quercetin induced HO-1 expression, at least in part, through p38MAPK.	Quercetin	60-69	mitogen activated protein kinase 14	Rattus norvegicus	121-128
15108355-0	2004	Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1.	Quercetin	10-19	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	70-75
15108355-0	2004	Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1.	Quercetin	10-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-112
15108355-0	2004	Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1.	Quercetin	10-19	jun proto-oncogene	Mus musculus	117-121
15108355-10	2004	Analysis of protein-DNA interaction by electrophoretic mobility shift assay (EMSA) performed on RAW cells showed that a pre-treatment with quercetin inhibited RANKL-induced nuclear factor kB (NF kappa B) and activator protein 1 (AP-1) activation.	Quercetin	139-148	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	159-164
15108355-10	2004	Analysis of protein-DNA interaction by electrophoretic mobility shift assay (EMSA) performed on RAW cells showed that a pre-treatment with quercetin inhibited RANKL-induced nuclear factor kB (NF kappa B) and activator protein 1 (AP-1) activation.	Quercetin	139-148	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	192-202
15108355-10	2004	Analysis of protein-DNA interaction by electrophoretic mobility shift assay (EMSA) performed on RAW cells showed that a pre-treatment with quercetin inhibited RANKL-induced nuclear factor kB (NF kappa B) and activator protein 1 (AP-1) activation.	Quercetin	139-148	jun proto-oncogene	Mus musculus	208-227
15108355-10	2004	Analysis of protein-DNA interaction by electrophoretic mobility shift assay (EMSA) performed on RAW cells showed that a pre-treatment with quercetin inhibited RANKL-induced nuclear factor kB (NF kappa B) and activator protein 1 (AP-1) activation.	Quercetin	139-148	jun proto-oncogene	Mus musculus	229-233
15108355-11	2004	NF kappa B and AP-1 are transcription factors highly involved in osteoclastic differentiation and their inhibition could play an important role in the decrease of osteoclastogenesis observed in the presence of quercetin.	Quercetin	210-219	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-10
15108355-11	2004	NF kappa B and AP-1 are transcription factors highly involved in osteoclastic differentiation and their inhibition could play an important role in the decrease of osteoclastogenesis observed in the presence of quercetin.	Quercetin	210-219	jun proto-oncogene	Mus musculus	15-19
15108355-12	2004	In conclusion, the present results demonstrate for the first time that quercetin, a flavonoid characterized by antioxidant activities, is a potent inhibitor of in vitro osteoclastic differentiation, via a mechanism involving NF kappa B and AP-1.	Quercetin	71-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	225-235
15108355-12	2004	In conclusion, the present results demonstrate for the first time that quercetin, a flavonoid characterized by antioxidant activities, is a potent inhibitor of in vitro osteoclastic differentiation, via a mechanism involving NF kappa B and AP-1.	Quercetin	71-80	jun proto-oncogene	Mus musculus	240-244
15133536-11	2004	Our findings suggest that quercetin and ginsenoside Rd have the potential to interact with conventional medicines that are metabolized by CYP2C9 and CYP3A4 in vivo.	Quercetin	26-35	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	138-144
15133536-11	2004	Our findings suggest that quercetin and ginsenoside Rd have the potential to interact with conventional medicines that are metabolized by CYP2C9 and CYP3A4 in vivo.	Quercetin	26-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	149-155
15100171-7	2004	We also determined, for comparison, two common bioflavonoids (quercetin and fisetin) for their inhibitory effects on human liver COMT-mediated O-methylation of catechol estrogens.	Quercetin	62-71	catechol-O-methyltransferase	Homo sapiens	129-133
14688022-7	2004	Quercetin also induced the cleavage of caspase-3, caspase-7 and PARP (poly ADP-ribose polymerase).	Quercetin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	70-96
14688022-8	2004	While Akt-1 and phosphorylated Akt-1 were inhibited, the extracellular signal-regulated kinase (ERK) was phosphorylated following quercetin treatment in a dose-dependent fashion.	Quercetin	130-139	mitogen-activated protein kinase 1	Homo sapiens	57-94
14688022-8	2004	While Akt-1 and phosphorylated Akt-1 were inhibited, the extracellular signal-regulated kinase (ERK) was phosphorylated following quercetin treatment in a dose-dependent fashion.	Quercetin	130-139	mitogen-activated protein kinase 1	Homo sapiens	96-99
14688022-10	2004	Quercetin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and cleavage of caspase-3 occurred 6 h after quercetin exposure and before cleavage of caspase-7 and PARP was detected.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	37-60
14688022-10	2004	Quercetin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and cleavage of caspase-3 occurred 6 h after quercetin exposure and before cleavage of caspase-7 and PARP was detected.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	62-65
14688022-10	2004	Quercetin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and cleavage of caspase-3 occurred 6 h after quercetin exposure and before cleavage of caspase-7 and PARP was detected.	Quercetin	0-9	caspase 3	Homo sapiens	83-92
14688022-10	2004	Quercetin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and cleavage of caspase-3 occurred 6 h after quercetin exposure and before cleavage of caspase-7 and PARP was detected.	Quercetin	0-9	caspase 7	Homo sapiens	154-163
14688022-10	2004	Quercetin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and cleavage of caspase-3 occurred 6 h after quercetin exposure and before cleavage of caspase-7 and PARP was detected.	Quercetin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	168-172
14688022-10	2004	Quercetin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and cleavage of caspase-3 occurred 6 h after quercetin exposure and before cleavage of caspase-7 and PARP was detected.	Quercetin	112-121	mitogen-activated protein kinase 8	Homo sapiens	37-60
14688022-10	2004	Quercetin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and cleavage of caspase-3 occurred 6 h after quercetin exposure and before cleavage of caspase-7 and PARP was detected.	Quercetin	112-121	mitogen-activated protein kinase 8	Homo sapiens	62-65
14688022-10	2004	Quercetin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and cleavage of caspase-3 occurred 6 h after quercetin exposure and before cleavage of caspase-7 and PARP was detected.	Quercetin	112-121	caspase 3	Homo sapiens	83-92
14688022-11	2004	Inhibition of MEK1/2 but not PI-3 kinase, p38 kinase or JNK abolished quercetin-induced phosphorylation of c-Jun, cleavage of caspase-3 and -7, cleavage of PARP and apoptosis.	Quercetin	70-79	mitogen-activated protein kinase kinase 1	Homo sapiens	14-20
14688022-11	2004	Inhibition of MEK1/2 but not PI-3 kinase, p38 kinase or JNK abolished quercetin-induced phosphorylation of c-Jun, cleavage of caspase-3 and -7, cleavage of PARP and apoptosis.	Quercetin	70-79	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-112
14688022-11	2004	Inhibition of MEK1/2 but not PI-3 kinase, p38 kinase or JNK abolished quercetin-induced phosphorylation of c-Jun, cleavage of caspase-3 and -7, cleavage of PARP and apoptosis.	Quercetin	70-79	caspase 3	Homo sapiens	126-142
14688022-11	2004	Inhibition of MEK1/2 but not PI-3 kinase, p38 kinase or JNK abolished quercetin-induced phosphorylation of c-Jun, cleavage of caspase-3 and -7, cleavage of PARP and apoptosis.	Quercetin	70-79	poly(ADP-ribose) polymerase 1	Homo sapiens	156-160
14688022-14	2004	The results suggest that in addition to inactivation of Akt-1 and alteration in the expression of the Bcl-2 family of proteins, activation of MEK-ERK is required for quercetin-induced apoptosis in A549 lung carcinoma cells.	Quercetin	166-175	BCL2 apoptosis regulator	Homo sapiens	102-107
14688022-14	2004	The results suggest that in addition to inactivation of Akt-1 and alteration in the expression of the Bcl-2 family of proteins, activation of MEK-ERK is required for quercetin-induced apoptosis in A549 lung carcinoma cells.	Quercetin	166-175	mitogen-activated protein kinase kinase 7	Homo sapiens	142-145
14688022-14	2004	The results suggest that in addition to inactivation of Akt-1 and alteration in the expression of the Bcl-2 family of proteins, activation of MEK-ERK is required for quercetin-induced apoptosis in A549 lung carcinoma cells.	Quercetin	166-175	mitogen-activated protein kinase 1	Homo sapiens	146-149
14688022-0	2004	The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells.	Quercetin	41-50	mitogen-activated protein kinase kinase 7	Homo sapiens	22-25
14688022-0	2004	The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells.	Quercetin	41-50	mitogen-activated protein kinase 1	Homo sapiens	26-29
14688022-4	2004	Concomitantly, quercetin treatments led to a 1.1-, 1.1-, 2.5- and 3.5-fold increase in Bax.	Quercetin	15-24	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
14688022-7	2004	Quercetin also induced the cleavage of caspase-3, caspase-7 and PARP (poly ADP-ribose polymerase).	Quercetin	0-9	caspase 3	Homo sapiens	39-48
14688022-7	2004	Quercetin also induced the cleavage of caspase-3, caspase-7 and PARP (poly ADP-ribose polymerase).	Quercetin	0-9	caspase 7	Homo sapiens	50-59
14688022-7	2004	Quercetin also induced the cleavage of caspase-3, caspase-7 and PARP (poly ADP-ribose polymerase).	Quercetin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	64-68
15112361-13	2004	After P-gp inhibitor verapamil was administered, the concentration of quercetin in model cells was increased.	Quercetin	70-79	ATP binding cassette subfamily B member 1	Homo sapiens	6-10
15112361-15	2004	With this model, quercetin can be found to be transported by P-gp, and it is a P-gp substrate.	Quercetin	17-26	ATP binding cassette subfamily B member 1	Homo sapiens	61-65
15112361-15	2004	With this model, quercetin can be found to be transported by P-gp, and it is a P-gp substrate.	Quercetin	17-26	ATP binding cassette subfamily B member 1	Homo sapiens	79-83
15041478-11	2004	To identify the GS-X pump responsible for the DNP-SG efflux in MCF7 cells, the effects of three characteristic flavonoids quercetin, flavone and taxifolin on MRP1 and MRP2 activity were studied using transfected MDCKII cells.	Quercetin	122-131	ATP binding cassette subfamily C member 1	Homo sapiens	16-20
15041478-4	2004	Other flavonoids like kaempferol, eriodictyol and quercetin showed a moderate GSTP1-1 inhibitory potential.	Quercetin	50-59	glutathione S-transferase pi 1	Homo sapiens	78-85
15041478-11	2004	To identify the GS-X pump responsible for the DNP-SG efflux in MCF7 cells, the effects of three characteristic flavonoids quercetin, flavone and taxifolin on MRP1 and MRP2 activity were studied using transfected MDCKII cells.	Quercetin	122-131	ATP binding cassette subfamily C member 1	Homo sapiens	158-162
15041478-11	2004	To identify the GS-X pump responsible for the DNP-SG efflux in MCF7 cells, the effects of three characteristic flavonoids quercetin, flavone and taxifolin on MRP1 and MRP2 activity were studied using transfected MDCKII cells.	Quercetin	122-131	ATP binding cassette subfamily C member 2	Homo sapiens	167-171
15041478-13	2004	In addition, the most potent GS-X pump inhibitor in the MCF7 cells, quercetin, did not affect MRP2-mediated transport activity.	Quercetin	68-77	ATP binding cassette subfamily C member 1	Homo sapiens	29-33
15056855-5	2004	Quercetin inhibited the increase of tartrate-resistant acid phosphatase (TRAP) activity of mononuclear preosteoclasts (pOCs) induced by receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL) in both MD and RAW cell cultures.	Quercetin	0-9	acid phosphatase 5, tartrate resistant	Mus musculus	36-71
15013846-0	2004	Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway.	Quercetin	52-61	alkaline phosphatase, placental	Homo sapiens	80-100
15013846-0	2004	Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway.	Quercetin	52-61	mitogen-activated protein kinase 1	Homo sapiens	145-148
15013846-3	2004	In this study, we investigated the in vitro effect of two widespread flavonols, quercetin and kaempferol, on alkaline phosphatase (ALP) activity in MG-63 cultured human osteoblasts.	Quercetin	80-89	alkaline phosphatase, placental	Homo sapiens	109-129
15056855-5	2004	Quercetin inhibited the increase of tartrate-resistant acid phosphatase (TRAP) activity of mononuclear preosteoclasts (pOCs) induced by receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL) in both MD and RAW cell cultures.	Quercetin	0-9	acid phosphatase 5, tartrate resistant	Mus musculus	73-77
15013846-3	2004	In this study, we investigated the in vitro effect of two widespread flavonols, quercetin and kaempferol, on alkaline phosphatase (ALP) activity in MG-63 cultured human osteoblasts.	Quercetin	80-89	alkaline phosphatase, placental	Homo sapiens	131-134
15056855-5	2004	Quercetin inhibited the increase of tartrate-resistant acid phosphatase (TRAP) activity of mononuclear preosteoclasts (pOCs) induced by receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL) in both MD and RAW cell cultures.	Quercetin	0-9	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	200-205
15056855-7	2004	Quercetin also suppressed both pit formation induced by osteoclasts on dentine slices and PTH-stimulated (45)Ca release in mouse long bone cultures.	Quercetin	0-9	parathyroid hormone	Mus musculus	90-93
15051824-3	2004	Because the transcription factor peroxisome proliferator activated receptor gamma (PPARgamma) was reported to downregulate inflammatory pathways, we further investigated the effect of quercetin on PPARgamma.	Quercetin	184-193	peroxisome proliferator activated receptor gamma	Homo sapiens	197-206
15255290-0	2004	Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid.	Quercetin	89-98	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	61-66
15255290-7	2004	When [Arg482]ABCG2-transfected HEK293 cells were incubated with SN-38 in the presence of 20 microM quercetin, cellular resistance to SN-38 was partly reversed.	Quercetin	99-108	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	13-18
15051824-2	2004	The present study focused on the effect of quercetin on linoleic acid-induced oxidative stress and the inflammatory pathways of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1).	Quercetin	43-52	nuclear factor kappa B subunit 1	Homo sapiens	151-160
15051824-6	2004	Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1).	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	61-70
15051824-2	2004	The present study focused on the effect of quercetin on linoleic acid-induced oxidative stress and the inflammatory pathways of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1).	Quercetin	43-52	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-185
15051824-6	2004	Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1).	Quercetin	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-79
15051824-6	2004	Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1).	Quercetin	0-9	interleukin 6	Homo sapiens	126-139
15051824-6	2004	Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1).	Quercetin	0-9	interleukin 6	Homo sapiens	141-145
15051824-6	2004	Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1).	Quercetin	0-9	vascular cell adhesion molecule 1	Homo sapiens	151-184
15051824-6	2004	Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1).	Quercetin	0-9	vascular cell adhesion molecule 1	Homo sapiens	186-192
15051824-7	2004	Cotreatment of linoleic acid plus quercetin or vitamin E also decreased linoleic acid-induced binding activity of PPARgamma.	Quercetin	34-43	peroxisome proliferator activated receptor gamma	Homo sapiens	114-123
15095149-5	2004	Quercetin and verapamil treatments reduced the endothelium-independent hyper-reactivity to KCl observed in the aorta of DOCA-salt-hypertensive rats, but only quercetin increased the contractile responses to angiotensin II, improved endothelial dysfunction and restored basal aortic Cu/Zn SOD expression, altered in DOCA-salt-treated rats.	Quercetin	0-9	angiotensinogen	Rattus norvegicus	207-221
15051824-2	2004	The present study focused on the effect of quercetin on linoleic acid-induced oxidative stress and the inflammatory pathways of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1).	Quercetin	43-52	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	187-191
15145447-13	2004	We report here, that luteolin and quercetin have a biphasic effect on the enol-keto conversion of phenylpyruvate mediated by MIF tautomerase.	Quercetin	34-43	macrophage migration inhibitory factor	Rattus norvegicus	125-128
15095149-5	2004	Quercetin and verapamil treatments reduced the endothelium-independent hyper-reactivity to KCl observed in the aorta of DOCA-salt-hypertensive rats, but only quercetin increased the contractile responses to angiotensin II, improved endothelial dysfunction and restored basal aortic Cu/Zn SOD expression, altered in DOCA-salt-treated rats.	Quercetin	158-167	angiotensinogen	Rattus norvegicus	207-221
15177039-8	2004	Our data suggest that genistein and quercetin induce different DNA-damage induced signaling pathways that, in the case of genistein, are highly ATM-dependent but, in the case of quercetin, may be ATM-dependent only for some downstream targets.	Quercetin	36-45	ATM serine/threonine kinase	Homo sapiens	144-147
14985096-4	2004	Thus, we investigated the effect of quercetin, a flavonoid, on ENaC mRNA expression in the kidney of hypertensive Dahl salt-sensitive rats.	Quercetin	36-45	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	63-67
14985096-6	2004	Quercetin diminished the alphaENaC mRNA expression in the kidney associated with reduction of the systolic blood pressure elevated by high-salt diet, suggesting that one of the mechanisms of the flavonoid"s antihypertensive effect on salt-sensitive hypertension would be mediated through downregulation of ENaC expression in the kidney.	Quercetin	0-9	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	30-34
15177039-8	2004	Our data suggest that genistein and quercetin induce different DNA-damage induced signaling pathways that, in the case of genistein, are highly ATM-dependent but, in the case of quercetin, may be ATM-dependent only for some downstream targets.	Quercetin	36-45	ATM serine/threonine kinase	Homo sapiens	196-199
15177039-0	2004	The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.	Quercetin	32-41	ATM serine/threonine kinase	Homo sapiens	144-147
15177039-0	2004	The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.	Quercetin	32-41	tumor protein p53	Homo sapiens	149-152
14980703-7	2004	Preadministration of the P-gp inhibitor PSC833 or GF120918 (10 mg/kg body wt) significantly increased colchicine K(in), but only GF120918 (able to inhibit breast cancer resistance protein, BCRP) affected K(in) for quercetin.	Quercetin	214-223	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	25-29
15177039-0	2004	The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.	Quercetin	32-41	H2A.X variant histone	Homo sapiens	157-169
15177039-7	2004	Like genistein, quercetin induced phosphorylation of ATM on serine 1981, and ATM-dependent phosphorylation of histone H2AX on serine 139; however, p53 accumulation and phosphorylation on serines 6, 9, 15, 20, 46, and 392 occurred in ATM-deficient cells, indicating that ATM is not required for quercetin-induced phosphorylation of p53.	Quercetin	16-25	ATM serine/threonine kinase	Homo sapiens	53-56
15177039-7	2004	Like genistein, quercetin induced phosphorylation of ATM on serine 1981, and ATM-dependent phosphorylation of histone H2AX on serine 139; however, p53 accumulation and phosphorylation on serines 6, 9, 15, 20, 46, and 392 occurred in ATM-deficient cells, indicating that ATM is not required for quercetin-induced phosphorylation of p53.	Quercetin	16-25	tumor protein p53	Homo sapiens	331-334
15129737-0	2004	Oxygen-copper (II) interplay in the repair of semi-oxidized urate by quercetin bound to human serum albumin.	Quercetin	69-78	albumin	Homo sapiens	94-107
14982785-4	2004	In addition to microbicidal activity, quercetin induced dose-dependent decreases in the levels of TNF-alpha and nitric oxide produced by activated human macrophages.	Quercetin	38-47	tumor necrosis factor	Homo sapiens	98-107
15185748-9	2004	The ability of two flavonoids, the flavanone naringenin and the flavanol quercetin, with respect of E2, to induce ERalpha activities has been studied in the human cervix epitheloid carcinoma cell line (HeLa) devoid of any estrogen receptors and rendered E2-sensitive by transient transfection with a human ERalpha expression vector.	Quercetin	73-82	estrogen receptor 1	Homo sapiens	114-121
15072439-6	2004	Some components (e.g., bergamottin and quercetin) from grapefruit juice were reported to modulate Pgp activity.	Quercetin	39-48	ATP binding cassette subfamily B member 1	Homo sapiens	98-101
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	Quercetin	143-152	interleukin 1 beta	Mus musculus	157-174
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	Quercetin	143-152	interleukin 1 beta	Mus musculus	176-184
14988445-0	2004	Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	35-51
14988445-3	2004	We show that the flavonoid quercetin metabolites as detected in human plasma at physiologically significant concentrations inhibit COX-2 expression in human lymphocytes ex vivo.	Quercetin	27-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	131-136
14988445-6	2004	However, the expression of COX-2 mRNA in lymphocytes was unchanged by the consumption of high-quercetin onions compared with the low-quercetin group.	Quercetin	94-103	cox2	Allium cepa	27-32
14988445-6	2004	However, the expression of COX-2 mRNA in lymphocytes was unchanged by the consumption of high-quercetin onions compared with the low-quercetin group.	Quercetin	133-142	cox2	Allium cepa	27-32
14767529-2	2004	In this report, we investigate the effects of quercetin on the growth of wild-type and mutant p53 nasopharyngeal carcinoma cell lines, HK1 and CNE2 respectively.	Quercetin	46-55	tumor protein p53	Homo sapiens	94-97
14767529-2	2004	In this report, we investigate the effects of quercetin on the growth of wild-type and mutant p53 nasopharyngeal carcinoma cell lines, HK1 and CNE2 respectively.	Quercetin	46-55	hexokinase 1	Homo sapiens	135-138
14767529-3	2004	The wild-type p53 HK1 was more susceptible to growth inhibition by quercetin than the mutant p53 CNE2.	Quercetin	67-76	tumor protein p53	Homo sapiens	14-17
14767529-3	2004	The wild-type p53 HK1 was more susceptible to growth inhibition by quercetin than the mutant p53 CNE2.	Quercetin	67-76	hexokinase 1	Homo sapiens	18-21
14767529-6	2004	Flow cytometry experiments revealed that quercetin-induced apoptosis during the first 24 h followed by necrosis in both HK1 and CNE2.	Quercetin	41-50	hexokinase 1	Homo sapiens	120-123
14767529-7	2004	Western blot experiments confirmed that cytotoxic killing of HK1 and CNE2 by quercetin was mediated by the up-regulation of pro-apoptotic protein Bad, caspase-3 and -7, resulting in cell death by apoptosis.	Quercetin	77-86	hexokinase 1	Homo sapiens	61-64
14767529-7	2004	Western blot experiments confirmed that cytotoxic killing of HK1 and CNE2 by quercetin was mediated by the up-regulation of pro-apoptotic protein Bad, caspase-3 and -7, resulting in cell death by apoptosis.	Quercetin	77-86	caspase 3	Homo sapiens	151-167
14767529-8	2004	Our study demonstrates that quercetin inhibits cell growth of nasopharyngeal carcinoma cell lines HK1 and CNE2 by inhibiting cell cycle progression to S phase.	Quercetin	28-37	hexokinase 1	Homo sapiens	98-101
14700523-11	2004	Wogonin and quercetin but not rutin, inhibitors of iNOS gene expression and NO production induced by LPS, showed the significant inhibition on LPS/TPA-induced transformation foci formation, accompanied by inhibiting iNOS gene expression, NO production and MMP9 activity.	Quercetin	12-21	nitric oxide synthase 2	Rattus norvegicus	51-55
14700523-11	2004	Wogonin and quercetin but not rutin, inhibitors of iNOS gene expression and NO production induced by LPS, showed the significant inhibition on LPS/TPA-induced transformation foci formation, accompanied by inhibiting iNOS gene expression, NO production and MMP9 activity.	Quercetin	12-21	nitric oxide synthase 2	Rattus norvegicus	216-220
14700523-11	2004	Wogonin and quercetin but not rutin, inhibitors of iNOS gene expression and NO production induced by LPS, showed the significant inhibition on LPS/TPA-induced transformation foci formation, accompanied by inhibiting iNOS gene expression, NO production and MMP9 activity.	Quercetin	12-21	matrix metallopeptidase 9	Rattus norvegicus	256-260
14757127-5	2004	In addition, quercetin stimulated the expression of mRNA for p21(waf1/cip1), which inhibits the activity of cyclin-dependent kinases, and inhibited the phosphorylation of histone H1.	Quercetin	13-22	cyclin dependent kinase inhibitor 1A	Homo sapiens	61-74
14757127-6	2004	Furthermore, after cells had ceased to proliferate, quercetin reduced the activity of alkaline phosphatase, the level of expression of mRNA for osteocalcin, the rate of deposition of Ca(2+), and the formation of mineralized nodules, all of which are markers of osteoblast differentiation.	Quercetin	52-61	bone gamma-carboxyglutamate protein	Homo sapiens	144-155
15043421-5	2004	The reported crystal structure of the Cdk5 complex with its activator p25 was used for docking studies, which also led to the identification of the two 6-methoxyflavones, kaempferol and quercetin, as well as the untested 6-methoxy derivatives of kaempferol and quercetin and the corresponding 6-hydroxy analogues as compounds exhibiting a good fit to the active site of the enzyme.	Quercetin	186-195	cyclin dependent kinase 5	Homo sapiens	38-42
15043421-5	2004	The reported crystal structure of the Cdk5 complex with its activator p25 was used for docking studies, which also led to the identification of the two 6-methoxyflavones, kaempferol and quercetin, as well as the untested 6-methoxy derivatives of kaempferol and quercetin and the corresponding 6-hydroxy analogues as compounds exhibiting a good fit to the active site of the enzyme.	Quercetin	186-195	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	70-73
15043421-5	2004	The reported crystal structure of the Cdk5 complex with its activator p25 was used for docking studies, which also led to the identification of the two 6-methoxyflavones, kaempferol and quercetin, as well as the untested 6-methoxy derivatives of kaempferol and quercetin and the corresponding 6-hydroxy analogues as compounds exhibiting a good fit to the active site of the enzyme.	Quercetin	261-270	cyclin dependent kinase 5	Homo sapiens	38-42
15043421-5	2004	The reported crystal structure of the Cdk5 complex with its activator p25 was used for docking studies, which also led to the identification of the two 6-methoxyflavones, kaempferol and quercetin, as well as the untested 6-methoxy derivatives of kaempferol and quercetin and the corresponding 6-hydroxy analogues as compounds exhibiting a good fit to the active site of the enzyme.	Quercetin	261-270	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	70-73
15072439-10	2004	Certain natural flavonols (e.g., kaempferol, quercetin, and galangin) are potent stimulators of the Pgp-mediated efflux of 7,12-dimethylbenz(a)-anthracene (a carcinogen).	Quercetin	45-54	ATP binding cassette subfamily B member 1	Homo sapiens	100-103
14717847-0	2004	Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes.	Quercetin	0-9	tyrosinase	Homo sapiens	77-87
15328920-4	2004	Treatment with 10 microM quercetin induced an increase of tyrosinase activity in cultured epidermis after 3-5 days in time-dependent manner.	Quercetin	25-34	tyrosinase	Homo sapiens	58-68
15328920-5	2004	In the quercetin-treated epidermis, furthermore, melanin content and tyrosinase expression were markedly increased, as shown by immunohistochemistry after a 7-day culture period.	Quercetin	7-16	tyrosinase	Homo sapiens	69-79
14717847-5	2004	As compared with controls, melanin content was increased about sevenfold by treatment with 20 microM (HMVII) or 1 microM (NHEM) quercetin for 7 d. Tyrosinase activity was also increased, to 61.8-fold higher than the control.	Quercetin	128-137	tyrosinase	Homo sapiens	147-157
15022163-8	2004	Quercetin also resulted in the activities of superoxide dismutase, catalase coming to near normal, along with the levels of vitamin C and vitamin E.	Quercetin	0-9	catalase	Rattus norvegicus	67-75
14717847-6	2004	The expression of tyrosinase protein was slightly increased by the addition of quercetin.	Quercetin	79-88	tyrosinase	Homo sapiens	18-28
14717847-8	2004	Tyrosinase activation by quercetin was blocked by actinomycin-D or by cycloheximide demonstrating that its actions in stimulating melanogenesis may involve both transcriptional and translational events.	Quercetin	25-34	tyrosinase	Homo sapiens	0-10
14717847-10	2004	Taken together, these results demonstrate that in human melanoma cells and in NHEM, quercetin stimulates melanogenesis by increasing tyrosinase activity and decreasing other factors such as melanogenic inhibitors.	Quercetin	84-93	tyrosinase	Homo sapiens	133-143
14698415-10	2004	These results indicate that quercetin and naringenin can exhibit inhibitory or stimulating effects on CYP1A2 mediated mutagenesis by MeIQ, depending on their concentrations.	Quercetin	28-37	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	102-108
14745173-3	2004	Lipopolysaccharide (LPS)-induced TNF-alpha production from macrophages was inhibited by treatment with flavone (luteolin, apigenin, and chrysin), flavonol (quercetin and myricetin), flavanonol (taxifolin), and anthocyanidin (cyanidin chloride) in vitro.	Quercetin	156-165	tumor necrosis factor	Mus musculus	33-42
15630180-6	2004	Results indicate that TNF-alpha and IL-6 accumulations were significantly reduced by 5 to 20 microM quercetin treatment, and 20 microM of alpha-tocopherol treatment.	Quercetin	100-109	tumor necrosis factor	Mus musculus	22-31
15630180-6	2004	Results indicate that TNF-alpha and IL-6 accumulations were significantly reduced by 5 to 20 microM quercetin treatment, and 20 microM of alpha-tocopherol treatment.	Quercetin	100-109	interleukin 6	Mus musculus	36-40
15630180-9	2004	Expressions of COX-2 and iNOS were effectively reduced by 5 microM quercetin treatment.	Quercetin	67-76	cytochrome c oxidase II, mitochondrial	Mus musculus	15-20
15630180-9	2004	Expressions of COX-2 and iNOS were effectively reduced by 5 microM quercetin treatment.	Quercetin	67-76	nitric oxide synthase 2, inducible	Mus musculus	25-29
14593496-0	2004	Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway.	Quercetin	0-9	matrix metallopeptidase 9	Mus musculus	79-88
14593496-6	2004	Quercetin dose-dependently decreased the gelatinolytic activity of pro-MMP-9.	Quercetin	0-9	matrix metallopeptidase 9	Mus musculus	67-76
14593496-8	2004	Quercetin showed a dose-dependent antagonism of increases in gelatinolytic activity of pro-MMP-9 induced by PDB and free fatty acid (another PKC activator).	Quercetin	0-9	matrix metallopeptidase 9	Mus musculus	87-96
14593496-9	2004	CONCLUSIONS: Together with the report that quercetin directly reduces PKC activity, the results reported here suggest that quercetin may inhibit the invasion of B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway.	Quercetin	123-132	matrix metallopeptidase 9	Mus musculus	189-198
14705020-4	2004	Quercetin belongs to the group of natural catecholic compounds and is known as a potent, competitive inhibitor of LOX.	Quercetin	0-9	lysyl oxidase	Homo sapiens	114-117
14976408-7	2004	In Caco-2 cells, quercetin and flavone increased early and late apoptosis parameters associated with a concomitant decline in pHi.	Quercetin	17-26	glucose-6-phosphate isomerase	Homo sapiens	126-129
14705020-5	2004	Structural analysis reveals that quercetin entrapped within LOX undergoes degradation, and the resulting compound has been identified by X-ray analysis as protocatechuic acid (3,4-dihydroxybenzoic acid) positioned near the iron site.	Quercetin	33-42	lysyl oxidase	Homo sapiens	60-63
15342215-0	2004	Inhibition of thrombin-induced signaling by resveratrol and quercetin: effects on adenosine nucleotide metabolism in endothelial cells and platelet-neutrophil interactions.	Quercetin	60-69	coagulation factor II, thrombin	Homo sapiens	14-22
15342215-3	2004	Whether the red wine polyphenols quercetin and resveratrol affect thrombin-dependent adenosine nucleotide, metabolism and thrombin-induced signaling is unknown.	Quercetin	33-42	coagulation factor II, thrombin	Homo sapiens	66-74
15342215-7	2004	RESULTS: Quercetin and resveratrol inhibited thrombin-induced ADP and ATP secretion from platelets in a concentration-dependent manner.	Quercetin	9-18	coagulation factor II, thrombin	Homo sapiens	45-53
15342215-3	2004	Whether the red wine polyphenols quercetin and resveratrol affect thrombin-dependent adenosine nucleotide, metabolism and thrombin-induced signaling is unknown.	Quercetin	33-42	coagulation factor II, thrombin	Homo sapiens	122-130
15342215-9	2004	Quercetin and resveratrol restored the decreased CD39/ATPdase activity in human umbilical vein endothelial cells, in response to thrombin as demonstrated by adenosine monophosphate (AMP) and adenosine increases in endothelial culture supernatants.	Quercetin	0-9	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	49-53
14609732-7	2003	In contrast, although quercetin (QU) activated ATM (but not ATR), it did not activate p38 kinase, GADD45 or p53.	Quercetin	22-31	ATM serine/threonine kinase	Homo sapiens	47-50
15342215-9	2004	Quercetin and resveratrol restored the decreased CD39/ATPdase activity in human umbilical vein endothelial cells, in response to thrombin as demonstrated by adenosine monophosphate (AMP) and adenosine increases in endothelial culture supernatants.	Quercetin	0-9	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	54-61
15342215-9	2004	Quercetin and resveratrol restored the decreased CD39/ATPdase activity in human umbilical vein endothelial cells, in response to thrombin as demonstrated by adenosine monophosphate (AMP) and adenosine increases in endothelial culture supernatants.	Quercetin	0-9	coagulation factor II, thrombin	Homo sapiens	129-137
15342215-11	2004	CONCLUSION: Quercetin and resveratrol interfere with the proinflammatory signaling of thrombin resulting in the inhibition of adenosine nucleotide secretion from activated platelets and decreased neutrophil function.	Quercetin	12-21	coagulation factor II, thrombin	Homo sapiens	86-94
14644160-5	2003	Furthermore, electrophoretic mobility shift assays revealed that quercetin (50 microM) treatment suppressed the GO-mediated DNA binding activity of redox state-sensitive transcription factors, such as NF-kappaB, AP-1, and p53.	Quercetin	65-74	jun proto-oncogene	Mus musculus	212-216
14644160-5	2003	Furthermore, electrophoretic mobility shift assays revealed that quercetin (50 microM) treatment suppressed the GO-mediated DNA binding activity of redox state-sensitive transcription factors, such as NF-kappaB, AP-1, and p53.	Quercetin	65-74	transformation related protein 53, pseudogene	Mus musculus	222-225
14644160-7	2003	More interestingly, quercetin treatment alone (50 microM) increased the DNA-binding activity of AP-1, which consisted of heterodimer of c-Jun and Fra-2.	Quercetin	20-29	jun proto-oncogene	Mus musculus	96-100
14644160-7	2003	More interestingly, quercetin treatment alone (50 microM) increased the DNA-binding activity of AP-1, which consisted of heterodimer of c-Jun and Fra-2.	Quercetin	20-29	jun proto-oncogene	Mus musculus	136-141
14644160-7	2003	More interestingly, quercetin treatment alone (50 microM) increased the DNA-binding activity of AP-1, which consisted of heterodimer of c-Jun and Fra-2.	Quercetin	20-29	fos-like antigen 2	Mus musculus	146-151
14642585-3	2003	Most compounds studied were significantly more active as inhibitors of 15-LO from soy beans than quercetin.	Quercetin	97-106	arachidonate 15-lipoxygenase	Homo sapiens	71-76
15572302-7	2004	Regarding the mechanisms, galangin, luteolin, chrysin, and quercetin induced apoptosis in a way that required the activation of caspases 3 and 8, but not caspase 9.	Quercetin	59-68	caspase 3	Homo sapiens	128-144
14563492-12	2003	3-OH Flavone, baicalein, kaempferol, and quercetin showed a more significant inhibition on LPS-induced NO production in HO-1/RAW264.7 cells than in parental RAW264.7 cells.	Quercetin	41-50	toll-like receptor 4	Mus musculus	91-94
12949046-5	2003	In intact HepG2 cells, quercetin inhibited cytochrome P450 (CYP)1A2, the main phase I enzyme responsible for PhIP bioactivation.	Quercetin	23-32	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	43-67
15320492-0	2003	D2-dopamine receptor and alpha2-adrenoreceptor-mediated analgesic response of quercetin.	Quercetin	78-87	dopamine receptor D2	Homo sapiens	0-20
14742143-11	2003	The potency of the inhibition for SULT1A1 (quercetin &gt; kaempferol &gt; genistein &gt; daidzein) suggests a dependency on the number and position of hydroxyl radicals in the flavonoid molecule.	Quercetin	43-52	sulfotransferase family 1A member 1	Rattus norvegicus	34-41
14643528-0	2003	Quercetin inhibits fibronectin production by keloid-derived fibroblasts.	Quercetin	0-9	fibronectin 1	Homo sapiens	19-30
12900416-6	2003	UGT78D1 catalyzed the transfer of rhamnose from UDP-rhamnose to the 3-OH position of quercetin and kaempferol, whereas UGT73C6 catalyzed the transfer of glucose from UDP-glucose to the 7-OH position of kaempferol-3-O-rhamnoside and quercetin-3-O-rhamnoside, respectively.	Quercetin	85-94	UDP-glucosyl transferase 78D1	Arabidopsis thaliana	0-7
14563492-2	2003	In the present study, flavonoids, including 3-OH flavone, baicalein, kaempferol, and quercetin, induced HO-1 gene expression at the protein and mRNA levels in the presence or absence of LPS in RAW264.7 macrophages.	Quercetin	85-94	heme oxygenase 1	Mus musculus	104-108
14563492-12	2003	3-OH Flavone, baicalein, kaempferol, and quercetin showed a more significant inhibition on LPS-induced NO production in HO-1/RAW264.7 cells than in parental RAW264.7 cells.	Quercetin	41-50	heme oxygenase 1	Mus musculus	120-124
14605528-6	2003	To evaluate dose-dependent inhibition of GGA-induced HSP70 expression by quercetin, rats were pretreated with progressive doses of quercetin before GGA administration.	Quercetin	73-82	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	53-58
14703737-7	2003	Chronic quercetin administration for 30 days also reversed age associated increase in TBARS levels and decline in forebrain total glutathione (GSH), SOD and catalase levels.	Quercetin	8-17	catalase	Mus musculus	157-165
14703737-8	2003	Chronic ethanol administration to young mice produced an increase in lipid peroxidation, and a decline in forebrain total glutathione (GSH), SOD and catalase levels, which was significantly reversed by the co-administration of quercetin (10, 25 and 50 mg/kg).	Quercetin	227-236	catalase	Mus musculus	149-157
14652680-4	2003	RESULTS: The beta-hexosaminidase release response to compound 48/80 induced by quercetin treatment was accompanied by a release of lactate dehydrogenase, suggesting that degranulation is not the only process triggered by compound 48/80 under these conditions.	Quercetin	79-88	O-GlcNAcase	Rattus norvegicus	13-32
14652680-5	2003	Quercetin treatment reduced the beta-hexosaminidase release response to concanavalin A. Precoating of the culture wells with rat fibronectin enhanced the beta-hexosaminidase response to calcimycin, but not to concanavalin A.	Quercetin	0-9	O-GlcNAcase	Rattus norvegicus	32-51
14652680-5	2003	Quercetin treatment reduced the beta-hexosaminidase release response to concanavalin A. Precoating of the culture wells with rat fibronectin enhanced the beta-hexosaminidase response to calcimycin, but not to concanavalin A.	Quercetin	0-9	fibronectin 1	Rattus norvegicus	129-140
14652680-5	2003	Quercetin treatment reduced the beta-hexosaminidase release response to concanavalin A. Precoating of the culture wells with rat fibronectin enhanced the beta-hexosaminidase response to calcimycin, but not to concanavalin A.	Quercetin	0-9	O-GlcNAcase	Rattus norvegicus	154-173
14605528-10	2003	MEASUREMENTS AND MAIN RESULTS: Western blot analysis using diaphragm homogenates obtained from normal rats showed that HSP70 expression peaked at 24 or 36 hrs after GGA administration and that pretreatment with &gt;10 mg/kg of quercetin blocked the induction of HSP70 expression by GGA.	Quercetin	227-236	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	119-124
14609317-0	2003	Pro-inflammatory effect of quercetin by dual blockade of angiotensin converting-enzyme and neutral endopeptidase in vivo.	Quercetin	27-36	angiotensin I converting enzyme	Rattus norvegicus	57-86
14617075-7	2003	Both quercetin and kaempferol competed with NPA for AtGSTF2 binding, indicating that all three compounds bind AtGSTF2 at the same site.	Quercetin	5-14	glutathione S-transferase PHI 2	Arabidopsis thaliana	52-59
14617075-7	2003	Both quercetin and kaempferol competed with NPA for AtGSTF2 binding, indicating that all three compounds bind AtGSTF2 at the same site.	Quercetin	5-14	glutathione S-transferase PHI 2	Arabidopsis thaliana	110-117
12970578-5	2003	EGCG at 50 muM and quercetin at 100 muM concentrations markedly inhibited CYP1A1 mRNA levels and enzyme activity.	Quercetin	19-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	74-80
12970578-6	2003	Furthermore, EGCG and quercetin downregulated the PCB 77-mediated increase in aryl hydrocarbon receptor (AhR)-DNA binding activity.	Quercetin	22-31	pyruvate carboxylase	Homo sapiens	50-53
12970578-6	2003	Furthermore, EGCG and quercetin downregulated the PCB 77-mediated increase in aryl hydrocarbon receptor (AhR)-DNA binding activity.	Quercetin	22-31	aryl hydrocarbon receptor	Homo sapiens	78-103
12970578-6	2003	Furthermore, EGCG and quercetin downregulated the PCB 77-mediated increase in aryl hydrocarbon receptor (AhR)-DNA binding activity.	Quercetin	22-31	aryl hydrocarbon receptor	Homo sapiens	105-108
12970578-7	2003	These data suggest that protective effects of EGCG and quercetin are initiated upstream from CYP1A1 and that these flavonoids may be of value for inhibiting the toxic effects of PCBs on vascular endothelial cells.	Quercetin	55-64	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
14519943-2	2003	Pretreatment (quercetin 25, 50 and 75 mg/kg body weight for 15 d+co-treatment of ethanol 18%+quercetin for 15 d and ethanol 18% for the 15 d) increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH) in comparison to the ethanol group.	Quercetin	14-23	catalase	Mus musculus	198-206
14519943-2	2003	Pretreatment (quercetin 25, 50 and 75 mg/kg body weight for 15 d+co-treatment of ethanol 18%+quercetin for 15 d and ethanol 18% for the 15 d) increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH) in comparison to the ethanol group.	Quercetin	14-23	catalase	Mus musculus	208-211
14519943-2	2003	Pretreatment (quercetin 25, 50 and 75 mg/kg body weight for 15 d+co-treatment of ethanol 18%+quercetin for 15 d and ethanol 18% for the 15 d) increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH) in comparison to the ethanol group.	Quercetin	14-23	glutathione reductase	Mus musculus	244-265
14519943-2	2003	Pretreatment (quercetin 25, 50 and 75 mg/kg body weight for 15 d+co-treatment of ethanol 18%+quercetin for 15 d and ethanol 18% for the 15 d) increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH) in comparison to the ethanol group.	Quercetin	14-23	glutathione reductase	Mus musculus	267-269
12928578-8	2003	Apigenin-7-glucoside showed more efficacy as compared with quercetin in both models that may be probably due to its greater efficacy to inhibit cyclooxygenase-2 and inducible nitric oxide synthase.	Quercetin	59-68	prostaglandin-endoperoxide synthase 2	Mus musculus	144-160
12928578-8	2003	Apigenin-7-glucoside showed more efficacy as compared with quercetin in both models that may be probably due to its greater efficacy to inhibit cyclooxygenase-2 and inducible nitric oxide synthase.	Quercetin	59-68	nitric oxide synthase 2, inducible	Mus musculus	165-196
14505808-7	2003	Furthermore, pretreatment of quercetin inhibited the activation of caspase-3, thereby both cleavage of poly(ADP-ribose) polymerase and degradation of inhibitor of caspase-activated DNase/DNA fragmentation factor by H(2)O(2) were completely abolished.	Quercetin	29-38	caspase 3	Rattus norvegicus	67-76
12869420-10	2003	Both small and large intestinal UGT enzyme activities were increased by quercetin, alpha-angelicalactone, coumarin, curcumin and flavone.	Quercetin	72-81	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	32-35
14625852-6	2003	Since HSP70 plays an important role in protecting cells under stress, we treated the 2774 cells with the HSP inhibitor quercetin in combination with FTI.	Quercetin	119-128	heat shock protein family A (Hsp70) member 4	Homo sapiens	6-11
14625852-6	2003	Since HSP70 plays an important role in protecting cells under stress, we treated the 2774 cells with the HSP inhibitor quercetin in combination with FTI.	Quercetin	119-128	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	6-9
14625852-8	2003	Inducible HSP70 by manumycin in surviving ovarian cancer cells was also inhibited by quercetin as demonstrated by enzyme-linked immunosorbent assay.	Quercetin	85-94	heat shock protein family A (Hsp70) member 4	Homo sapiens	10-15
12826665-9	2003	Together these data suggest that quercetin and to a lesser extent its O-methylated metabolites may induce neuronal death via a mechanism involving an inhibition of neuronal survival signaling through the inhibition of both Akt/PKB and ERK rather than by an activation of the c-Jun N-terminal kinase-mediated death pathway.	Quercetin	33-42	AKT serine/threonine kinase 1	Homo sapiens	223-230
14625852-9	2003	The inhibition of HSP70 by quercetin was correlated with enhancement of manumycin-induced mediated apoptosis in 2774 cells.	Quercetin	27-36	heat shock protein family A (Hsp70) member 4	Homo sapiens	18-23
14625852-10	2003	The inhibition of HSP70 by 50 microM quercetin was also correlated with a decreased expression of procaspase-3 and enhancement of specific cleavage of poly (ADP-ribose) polymerase into apoptotic fragment in 2774 cells treated with manumycin.	Quercetin	37-46	heat shock protein family A (Hsp70) member 4	Homo sapiens	18-23
14625852-10	2003	The inhibition of HSP70 by 50 microM quercetin was also correlated with a decreased expression of procaspase-3 and enhancement of specific cleavage of poly (ADP-ribose) polymerase into apoptotic fragment in 2774 cells treated with manumycin.	Quercetin	37-46	caspase 3	Homo sapiens	98-110
14625852-10	2003	The inhibition of HSP70 by 50 microM quercetin was also correlated with a decreased expression of procaspase-3 and enhancement of specific cleavage of poly (ADP-ribose) polymerase into apoptotic fragment in 2774 cells treated with manumycin.	Quercetin	37-46	poly(ADP-ribose) polymerase 1	Homo sapiens	151-179
12826665-9	2003	Together these data suggest that quercetin and to a lesser extent its O-methylated metabolites may induce neuronal death via a mechanism involving an inhibition of neuronal survival signaling through the inhibition of both Akt/PKB and ERK rather than by an activation of the c-Jun N-terminal kinase-mediated death pathway.	Quercetin	33-42	mitogen-activated protein kinase 1	Homo sapiens	235-238
13129835-8	2003	The results of the present study suggest that quercetin reversal of morphine tolerance and dependence may involve its ability to suppress nitric oxide synthase (NOS) activity.	Quercetin	46-55	nitric oxide synthase 1, neuronal	Mus musculus	138-159
12969528-0	2003	[Expression of HSP70 and P-glycoprotein (P-gp) in human hepatocarcinoma HepG2 cells induced by heat shock and inhibiting effect of quercetin on them].	Quercetin	131-140	heat shock protein family A (Hsp70) member 4	Homo sapiens	15-20
12969528-0	2003	[Expression of HSP70 and P-glycoprotein (P-gp) in human hepatocarcinoma HepG2 cells induced by heat shock and inhibiting effect of quercetin on them].	Quercetin	131-140	ATP binding cassette subfamily B member 1	Homo sapiens	25-39
12969528-0	2003	[Expression of HSP70 and P-glycoprotein (P-gp) in human hepatocarcinoma HepG2 cells induced by heat shock and inhibiting effect of quercetin on them].	Quercetin	131-140	ATP binding cassette subfamily B member 1	Homo sapiens	41-45
12969528-4	2003	In order to explore the relationship between HSP70 and P-gp, the human hepatocarcinoma line HepG2 cells was induced by heat shock in vitro, and the inhibiting effect of quercetin on them was observed at the same time to seek the method increasing the effectiveness of hyperthermal therapy on hepatocarcinoma.	Quercetin	169-178	heat shock protein family A (Hsp70) member 4	Homo sapiens	45-50
12969528-4	2003	In order to explore the relationship between HSP70 and P-gp, the human hepatocarcinoma line HepG2 cells was induced by heat shock in vitro, and the inhibiting effect of quercetin on them was observed at the same time to seek the method increasing the effectiveness of hyperthermal therapy on hepatocarcinoma.	Quercetin	169-178	ATP binding cassette subfamily B member 1	Homo sapiens	55-59
12969528-14	2003	(2) The overexpression of HSP70 and P-gp induced by heat shock could be inhibited effectively by quercetin in a dose-dependent manner, especially by quercetin at the concentrations of 100- 200 micromol/L(P&lt; 0.01).	Quercetin	97-106	heat shock protein family A (Hsp70) member 4	Homo sapiens	26-31
12969528-14	2003	(2) The overexpression of HSP70 and P-gp induced by heat shock could be inhibited effectively by quercetin in a dose-dependent manner, especially by quercetin at the concentrations of 100- 200 micromol/L(P&lt; 0.01).	Quercetin	97-106	ATP binding cassette subfamily B member 1	Homo sapiens	36-40
12969528-14	2003	(2) The overexpression of HSP70 and P-gp induced by heat shock could be inhibited effectively by quercetin in a dose-dependent manner, especially by quercetin at the concentrations of 100- 200 micromol/L(P&lt; 0.01).	Quercetin	149-158	heat shock protein family A (Hsp70) member 4	Homo sapiens	26-31
12969528-14	2003	(2) The overexpression of HSP70 and P-gp induced by heat shock could be inhibited effectively by quercetin in a dose-dependent manner, especially by quercetin at the concentrations of 100- 200 micromol/L(P&lt; 0.01).	Quercetin	149-158	ATP binding cassette subfamily B member 1	Homo sapiens	36-40
12969528-16	2003	(2) The overexpression of HSP70 and P-gp in HepG2 cells induced by heat shock can be inhibited by quercetin.	Quercetin	98-107	heat shock protein family A (Hsp70) member 4	Homo sapiens	26-31
12969528-16	2003	(2) The overexpression of HSP70 and P-gp in HepG2 cells induced by heat shock can be inhibited by quercetin.	Quercetin	98-107	ATP binding cassette subfamily B member 1	Homo sapiens	36-40
12958199-5	2003	rHuEPO treatment increased HSP70 expression in a dose-dependent manner in normal rat kidneys, and inhibition of HSP70 expression by quercetin eliminated the renoprotective effect of rHuEPO in ischemic kidneys.	Quercetin	132-141	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	112-117
12826665-0	2003	Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.	Quercetin	81-90	AKT serine/threonine kinase 1	Homo sapiens	27-30
12826665-0	2003	Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.	Quercetin	81-90	protein tyrosine kinase 2 beta	Homo sapiens	31-47
12826665-0	2003	Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.	Quercetin	81-90	mitogen-activated protein kinase 3	Homo sapiens	52-58
12826665-2	2003	We have investigated whether the observed strong neurotoxic potential of quercetin in primary cortical neurons may occur via specific and sensitive interactions within neuronal mitogen-activated protein kinase and Akt/protein kinase B (PKB) signaling cascades, both implicated in neuronal apoptosis.	Quercetin	73-82	AKT serine/threonine kinase 1	Homo sapiens	214-217
12826665-2	2003	We have investigated whether the observed strong neurotoxic potential of quercetin in primary cortical neurons may occur via specific and sensitive interactions within neuronal mitogen-activated protein kinase and Akt/protein kinase B (PKB) signaling cascades, both implicated in neuronal apoptosis.	Quercetin	73-82	protein tyrosine kinase 2 beta	Homo sapiens	218-234
12826665-2	2003	We have investigated whether the observed strong neurotoxic potential of quercetin in primary cortical neurons may occur via specific and sensitive interactions within neuronal mitogen-activated protein kinase and Akt/protein kinase B (PKB) signaling cascades, both implicated in neuronal apoptosis.	Quercetin	73-82	AKT serine/threonine kinase 1	Homo sapiens	236-239
12826665-3	2003	Quercetin induced potent inhibition of both Akt/PKB and ERK phosphorylation, resulting in reduced phosphorylation of BAD and a strong activation of caspase-3.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	44-51
12826665-3	2003	Quercetin induced potent inhibition of both Akt/PKB and ERK phosphorylation, resulting in reduced phosphorylation of BAD and a strong activation of caspase-3.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	56-59
12826665-3	2003	Quercetin induced potent inhibition of both Akt/PKB and ERK phosphorylation, resulting in reduced phosphorylation of BAD and a strong activation of caspase-3.	Quercetin	0-9	caspase 3	Homo sapiens	148-157
12826665-4	2003	High quercetin concentrations (30 microM) led to sustained loss of Akt phosphorylation and subsequent Akt cleavage by caspase-3, whereas at lower concentrations (&lt;10 microM) the inhibition of Akt phosphorylation was transient and eventually returned to basal levels.	Quercetin	5-14	AKT serine/threonine kinase 1	Homo sapiens	67-70
12826665-4	2003	High quercetin concentrations (30 microM) led to sustained loss of Akt phosphorylation and subsequent Akt cleavage by caspase-3, whereas at lower concentrations (&lt;10 microM) the inhibition of Akt phosphorylation was transient and eventually returned to basal levels.	Quercetin	5-14	AKT serine/threonine kinase 1	Homo sapiens	102-105
12826665-4	2003	High quercetin concentrations (30 microM) led to sustained loss of Akt phosphorylation and subsequent Akt cleavage by caspase-3, whereas at lower concentrations (&lt;10 microM) the inhibition of Akt phosphorylation was transient and eventually returned to basal levels.	Quercetin	5-14	caspase 3	Homo sapiens	118-127
12826665-4	2003	High quercetin concentrations (30 microM) led to sustained loss of Akt phosphorylation and subsequent Akt cleavage by caspase-3, whereas at lower concentrations (&lt;10 microM) the inhibition of Akt phosphorylation was transient and eventually returned to basal levels.	Quercetin	5-14	AKT serine/threonine kinase 1	Homo sapiens	102-105
12826665-6	2003	O-Methylated quercetin metabolites inhibited Akt/PKB to lesser extent and did not induce such strong activation of caspase-3, which was reflected in the lower amount of damage they inflicted on neurons.	Quercetin	13-22	AKT serine/threonine kinase 1	Homo sapiens	45-52
12756520-3	2003	Quercetin in a concentration range from 5 to 100 microM decreased manganese superoxide dismutase, glutathione peroxidase, and copper zinc superoxide dismutase mRNA expression levels each by 30-40% in rat hepatoma H4IIE cells.	Quercetin	0-9	superoxide dismutase 2	Rattus norvegicus	66-96
14606951-2	2003	Quercetin completely inhibited the synthesis and intracellular accumulation of 70-kD heat shock protein (HSP70) in response to hyperthermia or to treatment with sodium arsenite, whereas dihydroquercetin in the same or higher doses had no such effect.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	85-110
14606951-3	2003	Stress exposures under conditions of the quercetin-inhibited HSP70 expression significantly increased the percentage of dead and damaged cells compared to the same exposures in the absence of quercetin.	Quercetin	41-50	heat shock protein family A (Hsp70) member 4	Homo sapiens	61-66
12888923-0	2003	Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation.	Quercetin	46-55	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-20
12888923-0	2003	Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation.	Quercetin	46-55	erb-b2 receptor tyrosine kinase 3	Homo sapiens	25-31
12888923-0	2003	Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation.	Quercetin	46-55	tumor necrosis factor	Homo sapiens	65-97
12888923-0	2003	Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation.	Quercetin	46-55	transforming growth factor alpha	Homo sapiens	99-108
12888923-0	2003	Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation.	Quercetin	46-55	epidermal growth factor	Homo sapiens	115-138
12888923-0	2003	Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation.	Quercetin	46-55	epidermal growth factor	Homo sapiens	140-143
12888923-0	2003	Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation.	Quercetin	46-55	keratin 6A	Homo sapiens	159-163
12888923-1	2003	Because ErbB-2 receptor is involved in hormone-independency for growth and metastasis of prostate cancer cells, the aim was to investigate the effects of quercetin on ErbB-2 and ErbB-3 expression and its critical components such as MAP kinase and PI-3 kinase.	Quercetin	154-163	erb-b2 receptor tyrosine kinase 2	Homo sapiens	8-14
12888923-1	2003	Because ErbB-2 receptor is involved in hormone-independency for growth and metastasis of prostate cancer cells, the aim was to investigate the effects of quercetin on ErbB-2 and ErbB-3 expression and its critical components such as MAP kinase and PI-3 kinase.	Quercetin	154-163	erb-b2 receptor tyrosine kinase 3	Homo sapiens	178-184
12888923-4	2003	Treatment of PC-3 and LnCap cells with quercetin resulted in a dose-dependent growth inhibition.	Quercetin	39-48	keratin 6A	Homo sapiens	13-17
12888923-7	2003	Cyclin D1 expression and basal phosphorylation of c-Raf, MAPK, Elk-1 and Akt-1 in PC-3 cells was also inhibited by quercetin treatment.	Quercetin	115-124	cyclin D1	Homo sapiens	0-9
12888923-7	2003	Cyclin D1 expression and basal phosphorylation of c-Raf, MAPK, Elk-1 and Akt-1 in PC-3 cells was also inhibited by quercetin treatment.	Quercetin	115-124	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	50-55
12888923-7	2003	Cyclin D1 expression and basal phosphorylation of c-Raf, MAPK, Elk-1 and Akt-1 in PC-3 cells was also inhibited by quercetin treatment.	Quercetin	115-124	ETS transcription factor ELK1	Homo sapiens	63-68
12888923-7	2003	Cyclin D1 expression and basal phosphorylation of c-Raf, MAPK, Elk-1 and Akt-1 in PC-3 cells was also inhibited by quercetin treatment.	Quercetin	115-124	AKT serine/threonine kinase 1	Homo sapiens	73-78
12888923-7	2003	Cyclin D1 expression and basal phosphorylation of c-Raf, MAPK, Elk-1 and Akt-1 in PC-3 cells was also inhibited by quercetin treatment.	Quercetin	115-124	keratin 6A	Homo sapiens	82-86
12888923-8	2003	Co-treating PC-3 cells with quercetin significantly attenuated EGF- and TGF-alpha-induced growth and phosphorylation of ErbB-2, ErbB-3, c-Raf, MAPK kinase 1/2 (MEK1/2), MAPK, Elk-1 and Akt-1.	Quercetin	28-37	keratin 6A	Homo sapiens	12-16
12888923-8	2003	Co-treating PC-3 cells with quercetin significantly attenuated EGF- and TGF-alpha-induced growth and phosphorylation of ErbB-2, ErbB-3, c-Raf, MAPK kinase 1/2 (MEK1/2), MAPK, Elk-1 and Akt-1.	Quercetin	28-37	epidermal growth factor	Homo sapiens	63-66
12888923-8	2003	Co-treating PC-3 cells with quercetin significantly attenuated EGF- and TGF-alpha-induced growth and phosphorylation of ErbB-2, ErbB-3, c-Raf, MAPK kinase 1/2 (MEK1/2), MAPK, Elk-1 and Akt-1.	Quercetin	28-37	transforming growth factor alpha	Homo sapiens	72-81
12888923-8	2003	Co-treating PC-3 cells with quercetin significantly attenuated EGF- and TGF-alpha-induced growth and phosphorylation of ErbB-2, ErbB-3, c-Raf, MAPK kinase 1/2 (MEK1/2), MAPK, Elk-1 and Akt-1.	Quercetin	28-37	erb-b2 receptor tyrosine kinase 2	Homo sapiens	120-126
12888923-8	2003	Co-treating PC-3 cells with quercetin significantly attenuated EGF- and TGF-alpha-induced growth and phosphorylation of ErbB-2, ErbB-3, c-Raf, MAPK kinase 1/2 (MEK1/2), MAPK, Elk-1 and Akt-1.	Quercetin	28-37	erb-b2 receptor tyrosine kinase 3	Homo sapiens	128-134
12888923-8	2003	Co-treating PC-3 cells with quercetin significantly attenuated EGF- and TGF-alpha-induced growth and phosphorylation of ErbB-2, ErbB-3, c-Raf, MAPK kinase 1/2 (MEK1/2), MAPK, Elk-1 and Akt-1.	Quercetin	28-37	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	136-141
12888923-8	2003	Co-treating PC-3 cells with quercetin significantly attenuated EGF- and TGF-alpha-induced growth and phosphorylation of ErbB-2, ErbB-3, c-Raf, MAPK kinase 1/2 (MEK1/2), MAPK, Elk-1 and Akt-1.	Quercetin	28-37	mitogen-activated protein kinase kinase 1	Homo sapiens	160-166
12888923-8	2003	Co-treating PC-3 cells with quercetin significantly attenuated EGF- and TGF-alpha-induced growth and phosphorylation of ErbB-2, ErbB-3, c-Raf, MAPK kinase 1/2 (MEK1/2), MAPK, Elk-1 and Akt-1.	Quercetin	28-37	ETS transcription factor ELK1	Homo sapiens	175-180
12888923-8	2003	Co-treating PC-3 cells with quercetin significantly attenuated EGF- and TGF-alpha-induced growth and phosphorylation of ErbB-2, ErbB-3, c-Raf, MAPK kinase 1/2 (MEK1/2), MAPK, Elk-1 and Akt-1.	Quercetin	28-37	AKT serine/threonine kinase 1	Homo sapiens	185-190
12888923-9	2003	Since ErbB receptor is important for growth, metastasis and drug resistance, inhibition of ErbB-2 and ErbB-3 by pharmacological doses of quercetin may provide a new approach for treatment of prostate cancers.	Quercetin	137-146	epidermal growth factor receptor	Homo sapiens	6-10
12888923-9	2003	Since ErbB receptor is important for growth, metastasis and drug resistance, inhibition of ErbB-2 and ErbB-3 by pharmacological doses of quercetin may provide a new approach for treatment of prostate cancers.	Quercetin	137-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	91-97
12888923-9	2003	Since ErbB receptor is important for growth, metastasis and drug resistance, inhibition of ErbB-2 and ErbB-3 by pharmacological doses of quercetin may provide a new approach for treatment of prostate cancers.	Quercetin	137-146	erb-b2 receptor tyrosine kinase 3	Homo sapiens	102-108
12934110-0	2003	Quercetin elevates p27(Kip1) and arrests both primary and HPV16 E6/E7 transformed human keratinocytes in G1.	Quercetin	0-9	dynactin subunit 6	Homo sapiens	19-22
14514440-16	2003	Reduction of oxidative phosphorylation, inhibition of Na(+)-K(+)-ATPase, inhibition of glucokinase and inhibition of glucose 6-phosphatase could all contribute to the overall action of quercetin.	Quercetin	185-194	glucokinase	Rattus norvegicus	87-98
14514440-16	2003	Reduction of oxidative phosphorylation, inhibition of Na(+)-K(+)-ATPase, inhibition of glucokinase and inhibition of glucose 6-phosphatase could all contribute to the overall action of quercetin.	Quercetin	185-194	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	117-138
12934110-0	2003	Quercetin elevates p27(Kip1) and arrests both primary and HPV16 E6/E7 transformed human keratinocytes in G1.	Quercetin	0-9	cyclin dependent kinase inhibitor 1B	Homo sapiens	23-27
12967198-7	2003	A study using chemical inhibitors showed only quercetin (a CYP2C8 inhibitor) and ketoconazole (a CYP3A4/5 inhibitor) inhibited the DCQ formation.	Quercetin	46-55	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	59-65
14628445-5	2003	RESULTS: Que (0.3-2.4 mumol.L-1) was shown to inhibit the increase of P-selectin expression of thrombin activated platelets.	Quercetin	9-12	selectin P	Homo sapiens	70-80
12874837-0	2003	Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade.	Quercetin	42-51	caspase 3	Homo sapiens	142-151
12888656-0	2003	Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells.	Quercetin	22-31	transmembrane protein 132D	Homo sapiens	120-124
12888656-4	2003	Assays were performed to determine cell cycle kinetics, proliferation, apoptotic DNA-fragmentation and caspase-3-activity after 12, 24 and 48 h. Ellagic acid significantly potentiated the effects of quercetin (at 5 and 10 micro mol/L each) in the reduction of proliferation and viability and the induction of apoptosis.	Quercetin	199-208	caspase 3	Homo sapiens	103-112
12849725-4	2003	On the other hand, inhibition of NQO1 in both types of cells by dicoumarol significantly potentiated the inhibitory effect of quercetin on cell proliferation, revealing the role of NQO1 in cellular protection against quercetin.	Quercetin	126-135	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	33-37
12849725-4	2003	On the other hand, inhibition of NQO1 in both types of cells by dicoumarol significantly potentiated the inhibitory effect of quercetin on cell proliferation, revealing the role of NQO1 in cellular protection against quercetin.	Quercetin	126-135	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	181-185
12849725-4	2003	On the other hand, inhibition of NQO1 in both types of cells by dicoumarol significantly potentiated the inhibitory effect of quercetin on cell proliferation, revealing the role of NQO1 in cellular protection against quercetin.	Quercetin	217-226	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	33-37
12849725-4	2003	On the other hand, inhibition of NQO1 in both types of cells by dicoumarol significantly potentiated the inhibitory effect of quercetin on cell proliferation, revealing the role of NQO1 in cellular protection against quercetin.	Quercetin	217-226	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	181-185
12849725-5	2003	Altogether, these results can be explained by the hypothesis that both wild-type CHO and CHO+NQO1 cells contain sufficient NQO1 activity for optimal protection against the pro-oxidant effect of quercetin on cell proliferation.	Quercetin	194-203	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	93-97
12849725-5	2003	Altogether, these results can be explained by the hypothesis that both wild-type CHO and CHO+NQO1 cells contain sufficient NQO1 activity for optimal protection against the pro-oxidant effect of quercetin on cell proliferation.	Quercetin	194-203	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	123-127
12849725-6	2003	The results also point at a cellular NQO1 threshold for optimal protection against quercetin.	Quercetin	83-92	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	37-41
12911599-5	2003	Treatment with the flavonoids quercetin or catechin reduced PS exposure, thrombin formation, PIP2 level and resynthesis after platelet activation with collagen, thrombin or calcium ionophore.	Quercetin	30-39	coagulation factor II, thrombin	Homo sapiens	73-81
12911599-5	2003	Treatment with the flavonoids quercetin or catechin reduced PS exposure, thrombin formation, PIP2 level and resynthesis after platelet activation with collagen, thrombin or calcium ionophore.	Quercetin	30-39	coagulation factor II, thrombin	Homo sapiens	161-169
12849725-0	2003	The role of quinone reductase (NQO1) and quinone chemistry in quercetin cytotoxicity.	Quercetin	62-71	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	31-35
12849725-3	2003	Quercetin inhibited the proliferation of wild-type CHO and CHO+NQO1 cells to a similar extent without affecting cell viability, indicating that NQO1 enrichment of CHO cells did not provide increased protection.	Quercetin	0-9	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	63-67
12936704-6	2003	Normorphine formation decreased when incubated in the presence of troleandomycin or quercetin (by 46 and 33-36%, respectively), which further corroborates the contribution of CYP3A4 and CYP2C8.	Quercetin	84-93	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	175-181
12936704-6	2003	Normorphine formation decreased when incubated in the presence of troleandomycin or quercetin (by 46 and 33-36%, respectively), which further corroborates the contribution of CYP3A4 and CYP2C8.	Quercetin	84-93	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	186-192
14628445-5	2003	RESULTS: Que (0.3-2.4 mumol.L-1) was shown to inhibit the increase of P-selectin expression of thrombin activated platelets.	Quercetin	9-12	coagulation factor II, thrombin	Homo sapiens	95-103
12946265-9	2003	Blockade of HSP70 synthesis with quercetin (50 micro M) left unchanged the protective effect of adaptation.	Quercetin	33-42	heat shock protein family A (Hsp70) member 4	Homo sapiens	12-17
12926076-5	2003	Quercetin (&gt; or = 50 microM) applied for 24 hours inhibited cell proliferation, increased the cytotoxic activity of cDDP or VP-16 alone or combined with simultaneous hyperthermia and suppressed the development of thermotolerance.	Quercetin	0-9	host cell factor C1	Homo sapiens	127-132
12926076-7	2003	Quercetin (&gt; or = 50 microM), alone as well as in combination with thermochemotherapy, inhibited the expression of both HSP70 and HSP27.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	123-128
12926076-7	2003	Quercetin (&gt; or = 50 microM), alone as well as in combination with thermochemotherapy, inhibited the expression of both HSP70 and HSP27.	Quercetin	0-9	heat shock protein family B (small) member 1	Homo sapiens	133-138
12756207-7	2003	CQ N-desethylation was diminished when coincubated with quercetin (20-40% inhibition), ketoconazole, or troleandomycin (20-30% inhibition) and was strongly inhibited (80% inhibition) by a combination of ketoconazole and quercetin, which further corroborates the contribution of CYP2C8 and CYP3As.	Quercetin	56-65	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	278-284
12848784-8	2003	Quercetin, a known inhibitor of CYP2C8, inhibited the microsomal formation of SVA metabolites by about 25-30%.	Quercetin	0-9	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	32-38
12840208-6	2003	Genistein, quercetin, kaempferol and biochanin A, but not daidzein and rutin, counteracted the antiapoptotic effects of IGF-I.	Quercetin	11-20	insulin-like growth factor 1	Rattus norvegicus	120-125
12840208-8	2003	Genistein, biochanin A, quercetin and kaempferol reduced the insulin receptor substrate-1 (IRS-1) content of AT6.3 cells and prevented the down-regulation of IGF-I receptor beta in response to IGF-I binding.	Quercetin	24-33	insulin receptor substrate 1	Rattus norvegicus	61-89
12840208-8	2003	Genistein, biochanin A, quercetin and kaempferol reduced the insulin receptor substrate-1 (IRS-1) content of AT6.3 cells and prevented the down-regulation of IGF-I receptor beta in response to IGF-I binding.	Quercetin	24-33	insulin receptor substrate 1	Rattus norvegicus	91-96
12840208-8	2003	Genistein, biochanin A, quercetin and kaempferol reduced the insulin receptor substrate-1 (IRS-1) content of AT6.3 cells and prevented the down-regulation of IGF-I receptor beta in response to IGF-I binding.	Quercetin	24-33	insulin-like growth factor 1	Rattus norvegicus	158-163
12840208-8	2003	Genistein, biochanin A, quercetin and kaempferol reduced the insulin receptor substrate-1 (IRS-1) content of AT6.3 cells and prevented the down-regulation of IGF-I receptor beta in response to IGF-I binding.	Quercetin	24-33	insulin-like growth factor 1	Rattus norvegicus	193-198
12910683-9	2003	Immunohistochemical staining of ki67 showed that the ki67 label index (ki67-LI) displayed significant difference between Control group and Quercetin group, 5-Fu group, Quercetin + 5-Fu group, and so did the staining of Bcl-2.	Quercetin	139-148	antigen identified by monoclonal antibody Ki 67	Mus musculus	32-36
12910683-9	2003	Immunohistochemical staining of ki67 showed that the ki67 label index (ki67-LI) displayed significant difference between Control group and Quercetin group, 5-Fu group, Quercetin + 5-Fu group, and so did the staining of Bcl-2.	Quercetin	139-148	antigen identified by monoclonal antibody Ki 67	Mus musculus	53-57
12910683-9	2003	Immunohistochemical staining of ki67 showed that the ki67 label index (ki67-LI) displayed significant difference between Control group and Quercetin group, 5-Fu group, Quercetin + 5-Fu group, and so did the staining of Bcl-2.	Quercetin	139-148	antigen identified by monoclonal antibody Ki 67	Mus musculus	53-57
12910683-9	2003	Immunohistochemical staining of ki67 showed that the ki67 label index (ki67-LI) displayed significant difference between Control group and Quercetin group, 5-Fu group, Quercetin + 5-Fu group, and so did the staining of Bcl-2.	Quercetin	168-177	antigen identified by monoclonal antibody Ki 67	Mus musculus	32-36
12910683-9	2003	Immunohistochemical staining of ki67 showed that the ki67 label index (ki67-LI) displayed significant difference between Control group and Quercetin group, 5-Fu group, Quercetin + 5-Fu group, and so did the staining of Bcl-2.	Quercetin	168-177	antigen identified by monoclonal antibody Ki 67	Mus musculus	53-57
12910683-9	2003	Immunohistochemical staining of ki67 showed that the ki67 label index (ki67-LI) displayed significant difference between Control group and Quercetin group, 5-Fu group, Quercetin + 5-Fu group, and so did the staining of Bcl-2.	Quercetin	168-177	antigen identified by monoclonal antibody Ki 67	Mus musculus	53-57
12763027-5	2003	Quercetin was found to downregulate the activity of syk, which is upstream in the Band 3 tyrosine phosphorylation cascade, and partially prevented peroxynitrite-mediated phosphotyrosine phosphatase inhibition.	Quercetin	0-9	spleen associated tyrosine kinase	Homo sapiens	52-55
12771046-7	2003	In the kidney, the catechol-O-methyltransferase inhibitor quercetin and norepinephrine (10 micromol/L) reduced methylation of 2-hydroxyestradiol by approximately 90% and 41%, respectively.	Quercetin	58-67	catechol-O-methyltransferase	Rattus norvegicus	19-47
12724357-6	2003	Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour.	Quercetin	58-67	heat shock transcription factor 1	Homo sapiens	118-122
12724357-6	2003	Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour.	Quercetin	58-67	plasminogen activator, urokinase	Homo sapiens	159-162
12724357-6	2003	Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour.	Quercetin	58-67	matrix metallopeptidase 1	Homo sapiens	185-190
12724357-6	2003	Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour.	Quercetin	58-67	interleukin 6	Homo sapiens	118-121
12724357-6	2003	Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour.	Quercetin	58-67	plasminogen activator, urokinase	Homo sapiens	340-343
12724357-6	2003	Alternatively, incubation of untreated 8701-BC cells with quercetin, a flavonoid known to decrease the amount of free hsf1, is found to induce upregulation of uPa and downregulation of MMP-1, and an increase of matrigel invasion by cells, thus providing further supporting data of the involvement of hsf unavailability on the modulation of uPa and MMP-1 expression and on cell invasive behaviour.	Quercetin	58-67	matrix metallopeptidase 1	Homo sapiens	348-353
12756216-8	2003	The changes in gene expression were also seen in differentiated Caco-2 cells, where sulforaphane was responsible for induction of GSTA1 and quercetin for induction of UGT1A1.	Quercetin	140-149	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	167-173
12763102-9	2003	Further quercetin (50-100 mg kg(-1)) also reversed the haloperidol-induced decrease in forebrain SOD and catalase levels in rats.	Quercetin	8-17	catalase	Rattus norvegicus	105-113
12805248-15	2003	There were positive correlations between erythrocyte SOD activity and urinary concentration of quercetin or kaempferol.	Quercetin	95-104	superoxide dismutase 1	Homo sapiens	53-56
12761503-0	2003	Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Calpha.	Quercetin	10-19	Fas cell surface death receptor	Homo sapiens	33-37
12711835-0	2003	Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition.	Quercetin	0-9	catechol-O-methyltransferase	Rattus norvegicus	82-86
12711835-0	2003	Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition.	Quercetin	0-9	monoamine oxidase A	Rattus norvegicus	87-90
12711835-3	2003	Quercetin, a flavonoid present in many plants, is reported to inhibit COMT and MAO activities, the key enzymes involved in the metabolism of dopamine.	Quercetin	0-9	catechol-O-methyltransferase	Rattus norvegicus	70-74
12711835-3	2003	Quercetin, a flavonoid present in many plants, is reported to inhibit COMT and MAO activities, the key enzymes involved in the metabolism of dopamine.	Quercetin	0-9	monoamine oxidase A	Rattus norvegicus	79-82
12711835-18	2003	Quercetin through its COMT and MAO enzyme-inhibiting properties might potentiate the anticatatonic effect of L-dopa plus carbidopa treatment.	Quercetin	0-9	catechol-O-methyltransferase	Rattus norvegicus	22-26
12711835-18	2003	Quercetin through its COMT and MAO enzyme-inhibiting properties might potentiate the anticatatonic effect of L-dopa plus carbidopa treatment.	Quercetin	0-9	monoamine oxidase A	Rattus norvegicus	31-34
12669184-11	2003	Quercetin (25-100 mg/kg for 4 weeks) significantly reduced lipid peroxidation and restored GSH, SOD and catalase levels.	Quercetin	0-9	catalase	Rattus norvegicus	104-112
12761503-4	2003	We found that quercetin effects are mediated by the activation of PKCalpha.	Quercetin	14-23	protein kinase C alpha	Homo sapiens	66-74
12761503-5	2003	Treatment of HPB-ALL cells with quercetin slightly decreased PKCalpha activity, but when the flavonoid was associated with anti-CD95, the kinase activity increased by 12-fold with respect to the treatment with quercetin.	Quercetin	32-41	protein kinase C alpha	Homo sapiens	61-69
12761503-5	2003	Treatment of HPB-ALL cells with quercetin slightly decreased PKCalpha activity, but when the flavonoid was associated with anti-CD95, the kinase activity increased by 12-fold with respect to the treatment with quercetin.	Quercetin	210-219	Fas cell surface death receptor	Homo sapiens	128-132
12761503-7	2003	Our data confirm the involvement of specific PKC isoforms in CD95 signaling and suggest, for the first time, that quercetin targets this pathway increasing apoptogenic response in a cell line resistant to CD95-mediated apoptosis.	Quercetin	114-123	Fas cell surface death receptor	Homo sapiens	61-65
12761503-1	2003	We previously demonstrated that quercetin, a naturally occurring flavonoid with strong antioxidant properties, was able to enhance programmed cell death in HPB-acute lymphoblastic leukemia (ALL) cell line, derived from a human tymoma, when associated with the agonistic anti-CD95 monoclonal antibody.	Quercetin	32-41	Fas cell surface death receptor	Homo sapiens	275-279
12761503-7	2003	Our data confirm the involvement of specific PKC isoforms in CD95 signaling and suggest, for the first time, that quercetin targets this pathway increasing apoptogenic response in a cell line resistant to CD95-mediated apoptosis.	Quercetin	114-123	Fas cell surface death receptor	Homo sapiens	205-209
12761503-3	2003	In fact, other compounds structurally and functionally similar to quercetin, when associated with anti-CD95 antibody did not induce any CD95-mediated apoptosis, still maintaining their antioxidant capacity.	Quercetin	66-75	Fas cell surface death receptor	Homo sapiens	103-107
12686490-2	2003	The results show a time- and concentration-dependent inhibition of GSTP1-1 by quercetin.	Quercetin	78-87	glutathione S-transferase pi 1	Homo sapiens	67-74
12686490-1	2003	In the present study, the inhibition of human glutathione S-transferase P1-1 (GSTP1-1) by the flavonoid quercetin has been investigated.	Quercetin	104-113	glutathione S-transferase pi 1	Homo sapiens	78-85
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	77-86	glutathione S-transferase pi 1	Homo sapiens	0-7
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	77-86	tyrosinase	Homo sapiens	301-311
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	120-129	glutathione S-transferase pi 1	Homo sapiens	0-7
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	120-129	glutathione S-transferase pi 1	Homo sapiens	173-180
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	120-129	tyrosinase	Homo sapiens	301-311
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	120-129	glutathione S-transferase pi 1	Homo sapiens	0-7
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	120-129	glutathione S-transferase pi 1	Homo sapiens	173-180
12686490-3	2003	GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h incubation with 25 microM quercetin, whereas 1 and 10 microM quercetin inhibit GSTP1-1 activity to a significant extent reaching a maximum of 25 and 42% inhibition respectively after 2 h. Co-incubation with tyrosinase greatly enhances the rate of inactivation, whereas co-incubation with ascorbic acid or glutathione prevents this inhibition.	Quercetin	120-129	tyrosinase	Homo sapiens	301-311
12686490-5	2003	Inhibition studies with the GSTP1-1 mutants C47S, C101S and the double mutant C47S/C101S showed that cysteine 47 is the key residue in the interaction between quercetin and GSTP1-1.	Quercetin	159-168	glutathione S-transferase pi 1	Homo sapiens	28-35
12686490-5	2003	Inhibition studies with the GSTP1-1 mutants C47S, C101S and the double mutant C47S/C101S showed that cysteine 47 is the key residue in the interaction between quercetin and GSTP1-1.	Quercetin	159-168	glutathione S-transferase pi 1	Homo sapiens	173-180
12686490-6	2003	HPLC and LC-MS analysis of trypsin digested GSTP1-1 inhibited by quercetin did not show formation of a covalent bond between Cys 47 residue of the peptide fragment 45-54 and quercetin.	Quercetin	65-74	glutathione S-transferase pi 1	Homo sapiens	44-51
12686490-8	2003	Nevertheless, the results of the present study indicate that quinone-type oxidation products of quercetin likely act as specific active site inhibitors of GSTP1-1 by binding to cysteine 47.	Quercetin	96-105	glutathione S-transferase pi 1	Homo sapiens	155-162
12517755-10	2003	The flavonoid quercetin inhibits both AlkB and the 2OG oxygenase factor-inhibiting hypoxia-inducible factor (FIH) in vitro.	Quercetin	14-23	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	38-42
12672508-7	2003	The plant polyphenols namely tannic acid, butein, quercetin, morin, 2-hydroxychalcone and 2"-hydroxychalcone at 40 microM inhibited the GST-mediated conjugation of CMB with GSH by 38 to 62%.	Quercetin	50-59	glutathione S-transferase kappa 1	Homo sapiens	136-139
12741479-7	2003	Treatment with quercetin during 3 weeks improved liver histology and reduced collagen content, iNOS expression, and lipid peroxidation.	Quercetin	15-24	nitric oxide synthase 2	Rattus norvegicus	95-99
12695340-8	2003	Only quercetin produced accumulation of CYP3A4 mRNA (230 +/- 73% of control).	Quercetin	5-14	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	40-46
12695340-9	2003	When examined in a reporter gene assay, this flavonoid exhibited negligible increases in luciferase activity suggesting that quercetin induced CYP3A4 by mechanisms that may not involve PXR.	Quercetin	125-134	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	143-149
12871380-8	2003	Inhibition of phosphorylation of the Fc receptor gamma-chain suggests that quercetin inhibits early signaling events following stimulation of platelets with collagen.	Quercetin	75-84	Fc epsilon receptor Ig	Homo sapiens	37-60
12871380-9	2003	The activity of the kinases that phosphorylate the Fc receptor gamma-chain, Fyn and Lyn, as well as the tyrosine kinase Syk and phosphoinositide 3-kinase was also inhibited by quercetin in a concentration-dependent manner, both in whole cells and in isolation.	Quercetin	176-185	Fc epsilon receptor Ig	Homo sapiens	51-74
12871380-9	2003	The activity of the kinases that phosphorylate the Fc receptor gamma-chain, Fyn and Lyn, as well as the tyrosine kinase Syk and phosphoinositide 3-kinase was also inhibited by quercetin in a concentration-dependent manner, both in whole cells and in isolation.	Quercetin	176-185	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
12871380-9	2003	The activity of the kinases that phosphorylate the Fc receptor gamma-chain, Fyn and Lyn, as well as the tyrosine kinase Syk and phosphoinositide 3-kinase was also inhibited by quercetin in a concentration-dependent manner, both in whole cells and in isolation.	Quercetin	176-185	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	84-87
12871380-9	2003	The activity of the kinases that phosphorylate the Fc receptor gamma-chain, Fyn and Lyn, as well as the tyrosine kinase Syk and phosphoinositide 3-kinase was also inhibited by quercetin in a concentration-dependent manner, both in whole cells and in isolation.	Quercetin	176-185	spleen associated tyrosine kinase	Homo sapiens	120-123
12871381-0	2003	Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells.	Quercetin	16-25	coagulation factor III, tissue factor	Homo sapiens	40-53
12871381-4	2003	OBJECTIVES: We investigated the role of resveratrol and quercetin on TF expression by endothelial and mononuclear cells (MN).	Quercetin	56-65	coagulation factor III, tissue factor	Homo sapiens	69-71
12871381-6	2003	RESULTS: In both cell types, TF activity induced by any agonist was significantly reduced by resveratrol or quercetin in a dose-dependent fashion.	Quercetin	108-117	coagulation factor III, tissue factor	Homo sapiens	29-31
12672908-8	2003	The antioxidants, (-)epigallocatechin gallate and quercetin, inhibited endothelial apoptosis, enhanced the expression of bcl-2 protein and inhibited the expression of bax protein and the cleavage and activation of caspase-3.	Quercetin	50-59	BCL2 apoptosis regulator	Homo sapiens	121-126
12672908-8	2003	The antioxidants, (-)epigallocatechin gallate and quercetin, inhibited endothelial apoptosis, enhanced the expression of bcl-2 protein and inhibited the expression of bax protein and the cleavage and activation of caspase-3.	Quercetin	50-59	BCL2 associated X, apoptosis regulator	Homo sapiens	167-170
12672908-8	2003	The antioxidants, (-)epigallocatechin gallate and quercetin, inhibited endothelial apoptosis, enhanced the expression of bcl-2 protein and inhibited the expression of bax protein and the cleavage and activation of caspase-3.	Quercetin	50-59	caspase 3	Homo sapiens	214-223
12517755-11	2003	FIH inhibition by quercetin occurs in the presence of excess iron indicating a specific interaction, while the inhibition of AlkB by quercetin is, predominantly, due to nonspecific iron chelation.	Quercetin	133-142	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	125-129
12589822-0	2003	Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	86-92
12747002-8	2003	The increases in plasma GPT, GOT activities and MDA concentration after hepatic ischemia-reperfusion injury were reduced significantly by pretreatment with quercetin.	Quercetin	156-165	glutamic--pyruvic transaminase	Rattus norvegicus	24-27
12747002-9	2003	Hepatic content of GSH and activities of SOD, GSH-Px and TAOC were restored remarkably while the ROS and MDA contents were significantly diminished by quercetin pretreatment after ischemia-reperfusion injury.	Quercetin	151-160	glutathione peroxidase 1	Rattus norvegicus	46-52
12624000-4	2003	The inhibitory effects of estradiol were blocked by the COMT inhibitors OR486 and quercetin.	Quercetin	82-91	catechol-O-methyltransferase	Homo sapiens	56-60
12724041-3	2003	Since quercetin is a phytoestrogen and potent antioxidant, it is possible that it may activate GC-A or other guanylate cyclase isoforms.	Quercetin	6-15	grancalcin	Sus scrofa	95-99
12724041-4	2003	We examined whether quercetin activates GC-A or GC-B (the receptor for C-type natriuretic peptide, CNP) in PC12 and porcine kidney proximal tubular LLC-PK1 cells.	Quercetin	20-29	grancalcin	Sus scrofa	40-44
12724041-4	2003	We examined whether quercetin activates GC-A or GC-B (the receptor for C-type natriuretic peptide, CNP) in PC12 and porcine kidney proximal tubular LLC-PK1 cells.	Quercetin	20-29	natriuretic peptide C	Sus scrofa	71-97
12724041-6	2003	Quercetin inhibited CNP-stimulated GC-B activity, but had little effect on ANF-stimulated GC-A activity in PC12 cells, suggesting that quercetin mainly activates GC-B in PC12 cells.	Quercetin	0-9	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	20-23
12724041-6	2003	Quercetin inhibited CNP-stimulated GC-B activity, but had little effect on ANF-stimulated GC-A activity in PC12 cells, suggesting that quercetin mainly activates GC-B in PC12 cells.	Quercetin	0-9	natriuretic peptide receptor 2	Rattus norvegicus	35-39
12724041-6	2003	Quercetin inhibited CNP-stimulated GC-B activity, but had little effect on ANF-stimulated GC-A activity in PC12 cells, suggesting that quercetin mainly activates GC-B in PC12 cells.	Quercetin	135-144	natriuretic peptide receptor 2	Rattus norvegicus	162-166
12724041-8	2003	Furthermore, quercetin had a small effect on ANF-stimulated GC-A activity and had no effect on soluble guanylate cyclase activity in LLC-PK1 cells, suggesting that quercetin does not activate GC-A, GC-B or soluble guanylate cyclase in LLC-PK1 cells.	Quercetin	13-22	natriuretic peptides A	Sus scrofa	45-48
12724041-8	2003	Furthermore, quercetin had a small effect on ANF-stimulated GC-A activity and had no effect on soluble guanylate cyclase activity in LLC-PK1 cells, suggesting that quercetin does not activate GC-A, GC-B or soluble guanylate cyclase in LLC-PK1 cells.	Quercetin	13-22	grancalcin	Sus scrofa	60-64
12724041-10	2003	These results indicate that quercetin activates the GC-B isoform in PC12 cells, but activates an unknown membrane-bound guanylate cyclase isoform in LLC-PK1 cells.	Quercetin	28-37	natriuretic peptide receptor 2	Rattus norvegicus	52-56
12606047-2	2003	The oxidation of LDL was inhibited by micromolar concentrations of flavonoids such as (-)-epicatechin, quercetin, rutin, taxifolin and luteolin, presumably via scavenging of the MPO-derived NO(2) radical.	Quercetin	103-112	myeloperoxidase	Homo sapiens	178-181
12589822-0	2003	Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	121-147
12589822-2	2003	Quercetin, a bioflanoid present in the human diet, is known to inhibit angiotensin II-induced hypertrophy and serum-induced smooth muscle cell proliferation.	Quercetin	0-9	angiotensinogen	Homo sapiens	71-85
12589822-4	2003	In this study, we investigated whether quercetin exerts the multiple suppressive effects on cytokine TNF-alpha-induced human aortic smooth muscle cells (HASMC).	Quercetin	39-48	tumor necrosis factor	Homo sapiens	101-110
12589822-5	2003	Treatment of quercetin showed potent inhibitory effects on the DNA synthesis of cultured HASMC in the presence of TNF-alpha.	Quercetin	13-22	tumor necrosis factor	Homo sapiens	114-123
12589822-7	2003	Treatment of quercetin, which induced a cell-cycle block in G1-phase, induced down-regulation of cyclins and CDKs and up-regulation of the CDK inhibitor p21 expression, whereas up-regulation of p27 or p53 by quercetin was not observed.	Quercetin	13-22	H3 histone pseudogene 16	Homo sapiens	153-156
12589822-7	2003	Treatment of quercetin, which induced a cell-cycle block in G1-phase, induced down-regulation of cyclins and CDKs and up-regulation of the CDK inhibitor p21 expression, whereas up-regulation of p27 or p53 by quercetin was not observed.	Quercetin	13-22	interferon alpha inducible protein 27	Homo sapiens	194-197
12589822-7	2003	Treatment of quercetin, which induced a cell-cycle block in G1-phase, induced down-regulation of cyclins and CDKs and up-regulation of the CDK inhibitor p21 expression, whereas up-regulation of p27 or p53 by quercetin was not observed.	Quercetin	13-22	tumor protein p53	Homo sapiens	201-204
12589822-7	2003	Treatment of quercetin, which induced a cell-cycle block in G1-phase, induced down-regulation of cyclins and CDKs and up-regulation of the CDK inhibitor p21 expression, whereas up-regulation of p27 or p53 by quercetin was not observed.	Quercetin	208-217	interferon alpha inducible protein 27	Homo sapiens	194-197
12589822-7	2003	Treatment of quercetin, which induced a cell-cycle block in G1-phase, induced down-regulation of cyclins and CDKs and up-regulation of the CDK inhibitor p21 expression, whereas up-regulation of p27 or p53 by quercetin was not observed.	Quercetin	208-217	tumor protein p53	Homo sapiens	201-204
12589822-8	2003	Because anti-atherogenic effects need not be limited to antiproliferation, we decided to examine whether quercetin exerted inhibitory effects on matrix metalloproteinase-9 (MMP-9) activity in TNF-alpha-induced HASMC.	Quercetin	105-114	matrix metallopeptidase 9	Homo sapiens	145-171
12589822-8	2003	Because anti-atherogenic effects need not be limited to antiproliferation, we decided to examine whether quercetin exerted inhibitory effects on matrix metalloproteinase-9 (MMP-9) activity in TNF-alpha-induced HASMC.	Quercetin	105-114	matrix metallopeptidase 9	Homo sapiens	173-178
12589822-8	2003	Because anti-atherogenic effects need not be limited to antiproliferation, we decided to examine whether quercetin exerted inhibitory effects on matrix metalloproteinase-9 (MMP-9) activity in TNF-alpha-induced HASMC.	Quercetin	105-114	tumor necrosis factor	Homo sapiens	192-201
12589822-9	2003	Quercetin inhibited TNF-alpha-induced MMP-9 secretion on HASMC in a dose-dependent manner.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	20-29
12589822-9	2003	Quercetin inhibited TNF-alpha-induced MMP-9 secretion on HASMC in a dose-dependent manner.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	38-43
12589822-11	2003	These findings indicate the efficacy of quercetin in inhibiting cell proliferation, G1- to S-phase cell-cycle progress, and MMP-9 expression through the transcription factors NF-kappaB and AP-1 on TNF-alpha-induced HASMC.	Quercetin	40-49	matrix metallopeptidase 9	Homo sapiens	124-129
12589822-11	2003	These findings indicate the efficacy of quercetin in inhibiting cell proliferation, G1- to S-phase cell-cycle progress, and MMP-9 expression through the transcription factors NF-kappaB and AP-1 on TNF-alpha-induced HASMC.	Quercetin	40-49	tumor necrosis factor	Homo sapiens	197-206
12532374-4	2003	Biochanin-A, genistein, quercetin, chalcone, silymarin, phloretin, morin, and kaempferol, at 100 microM concentrations, all significantly increased the accumulation of both DNM and VBL in Panc-1 cells, with morin increasing DNM and VBL accumulation by 546 +/- 50% (mean +/- SE, n = 9) and 553 +/- 37% (n = 9), respectively.	Quercetin	24-33	dynamin 1	Homo sapiens	173-184
12576520-5	2003	However, the preincubation of H2O2-treated EC with the flavonoids hesperedin, naringin, and quercetin strongly inhibited AT activity and activated TAL by 290%, 340%, and 250%, respectively.	Quercetin	92-101	transaldolase 1	Homo sapiens	147-150
12527338-0	2003	Probing the binding of the flavonoid, quercetin to human serum albumin by circular dichroism, electronic absorption spectroscopy and molecular modelling methods.	Quercetin	38-47	albumin	Homo sapiens	57-70
12532374-4	2003	Biochanin-A, genistein, quercetin, chalcone, silymarin, phloretin, morin, and kaempferol, at 100 microM concentrations, all significantly increased the accumulation of both DNM and VBL in Panc-1 cells, with morin increasing DNM and VBL accumulation by 546 +/- 50% (mean +/- SE, n = 9) and 553 +/- 37% (n = 9), respectively.	Quercetin	24-33	dynamin 1	Homo sapiens	224-235
12532374-9	2003	These results therefore indicate that the flavonoids morin, chalcone, silymarin, phloretin, genistein, quercetin, biochanin A, and kaempferol can inhibit MRP1-mediated drug transport, effects that may involve binding interactions with MRP1, as well as modulation of GSH concentrations.	Quercetin	103-112	ATP binding cassette subfamily C member 1	Homo sapiens	154-158
12532374-9	2003	These results therefore indicate that the flavonoids morin, chalcone, silymarin, phloretin, genistein, quercetin, biochanin A, and kaempferol can inhibit MRP1-mediated drug transport, effects that may involve binding interactions with MRP1, as well as modulation of GSH concentrations.	Quercetin	103-112	ATP binding cassette subfamily C member 1	Homo sapiens	235-239
12588662-3	2003	This study was designed to investigate the effect of five flavone derivatives variously substituted with hydroxyl groups (chrysin, galangin, kaempferol, quercetin and myricetin) on interleukin-1beta (IL-1beta) gene expression in stimulated RAW 264.7 macrophages.	Quercetin	153-162	interleukin 1 beta	Mus musculus	181-198
14649542-0	2003	Epidermal growth factor-responsive laryngeal squamous cancer cell line Hep2 is more sensitive than unresponsive CO-K3 one to quercetin and tamoxifen apoptotic effects.	Quercetin	125-134	epidermal growth factor	Homo sapiens	0-23
12469199-0	2003	Quercetin regulates growth of Ishikawa cells through the suppression of EGF and cyclin D1.	Quercetin	0-9	epidermal growth factor	Homo sapiens	72-75
12469199-0	2003	Quercetin regulates growth of Ishikawa cells through the suppression of EGF and cyclin D1.	Quercetin	0-9	cyclin D1	Homo sapiens	80-89
12469199-5	2003	The gene and protein expression data suggest that quercetin treatment (100 micro M) significantly decreased EGF and cyclin D1, whereas VEGF was up-regulated in Ishiwaka cell lines.	Quercetin	50-59	epidermal growth factor	Homo sapiens	108-111
12469199-5	2003	The gene and protein expression data suggest that quercetin treatment (100 micro M) significantly decreased EGF and cyclin D1, whereas VEGF was up-regulated in Ishiwaka cell lines.	Quercetin	50-59	cyclin D1	Homo sapiens	116-125
12469199-7	2003	The present study suggests that quercetin can suppress proliferation of Ishikawa cells through down-regulation of EGF and cyclin D1.	Quercetin	32-41	epidermal growth factor	Homo sapiens	114-117
12469199-7	2003	The present study suggests that quercetin can suppress proliferation of Ishikawa cells through down-regulation of EGF and cyclin D1.	Quercetin	32-41	cyclin D1	Homo sapiens	122-131
12504347-7	2003	Gastric tissue thiobarbituric acid reactive substance levels, carbonyl compounds, histamine levels and myeloperoxidase activities were found to be increased in ethanol treated rats and quercetin treatment reversed these increases.	Quercetin	185-194	myeloperoxidase	Rattus norvegicus	103-118
12524154-7	2003	After exposure to quercetin, a decrease in the expression and activity of matrix metalloproteinase-2, which is involved in the angiogenic process of migration, invasion, and tube formation, was observed by reverse transcription-polymerase chain reaction (RT-PCR) and gelatin zymography.	Quercetin	18-27	matrix metallopeptidase 2	Homo sapiens	74-100
12524154-8	2003	These findings suggest that quercetin has antiangiogenic potential and that this effect may be related to an influence on the expression and activity of matrix metalloproteinase-2.	Quercetin	28-37	matrix metallopeptidase 2	Homo sapiens	153-179
14587065-0	2003	Binding of quercetin with human serum albumin: a critical spectroscopic study.	Quercetin	11-20	albumin	Homo sapiens	32-45
14587065-4	2003	Upon binding to human serum albumin (HSA), quercetin undergoes dramatic enhancement in its fluorescence emission intensity, along with the appearance of dual emission behavior, consisting of normal and excited-state proton transfer (ESPT) fluorescence.	Quercetin	43-52	albumin	Homo sapiens	22-35
12485947-6	2003	In the present study, we found that stimulation of GSH transport in inside-out MRP1-enriched membrane vesicles by apigenin, naringenin, genistein, and quercetin was maximum at a concentration of 30 microM.	Quercetin	151-160	ATP binding cassette subfamily B member 1	Homo sapiens	79-83
12619901-3	2003	Quercetin strongly reduced activation of phosphorylated ERK kinase and p38 MAP kinase but not JNK MAP kinase by LPS treatment.	Quercetin	0-9	mitogen-activated protein kinase 14	Mus musculus	71-74
12619901-5	2003	Quercetin may exert its anti-inflammatory and immunomodulatory properties in the effect molecules such as proinflammatory cytokines and NO/iNOS by suppressing the activation of ERK and p38 MAP kinase, and NF-kappaB/IkappaB signal transduction pathways.	Quercetin	0-9	mitogen-activated protein kinase 14	Mus musculus	185-188
14649542-11	2003	We conclude that the capacity of Q and TAM to increase apoptosis in EGFR-activated cells makes these compounds possible chemopreventive drugs in subjects at risk of developing laryngeal cancer.	Quercetin	33-34	epidermal growth factor receptor	Homo sapiens	68-72
12445814-0	2002	The interaction of quercetin with human serum albumin: a fluorescence spectroscopic study.	Quercetin	19-28	albumin	Homo sapiens	40-53
14640900-5	2003	In this work, we investigated the effects of daunorubicin and quercetin on mitochondrial enzyme activities such as ATPase, glutathione peroxidase (GPx) and glutathione reductase (GR).	Quercetin	62-71	glutathione-disulfide reductase	Rattus norvegicus	156-177
14640900-5	2003	In this work, we investigated the effects of daunorubicin and quercetin on mitochondrial enzyme activities such as ATPase, glutathione peroxidase (GPx) and glutathione reductase (GR).	Quercetin	62-71	glutathione-disulfide reductase	Rattus norvegicus	179-181
12431781-0	2002	The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells.	Quercetin	15-24	interferon gamma	Homo sapiens	51-66
12431781-0	2002	The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells.	Quercetin	15-24	interleukin 4	Homo sapiens	77-80
12431781-7	2002	Quercetin significantly induces the gene expression as well as the production of Th-1 derived IFNgamma and the downregulates Th-2 derived IL-4 by normal PBMC.	Quercetin	0-9	interferon gamma	Homo sapiens	94-102
12431781-7	2002	Quercetin significantly induces the gene expression as well as the production of Th-1 derived IFNgamma and the downregulates Th-2 derived IL-4 by normal PBMC.	Quercetin	0-9	interleukin 4	Homo sapiens	138-142
12431781-8	2002	Further, quercetin treatment increased the phenotypic expression of IFNgamma cells and decreased IL-4 positive cells by FACS analysis, which corroborate with protein secretion and gene expression studies.	Quercetin	9-18	interferon gamma	Homo sapiens	68-76
12431781-8	2002	Further, quercetin treatment increased the phenotypic expression of IFNgamma cells and decreased IL-4 positive cells by FACS analysis, which corroborate with protein secretion and gene expression studies.	Quercetin	9-18	interleukin 4	Homo sapiens	97-101
12431781-9	2002	These results suggest that the beneficial immuno-stimulatory effects of quercetin may be mediated through the induction of Th-1 derived cytokine, IFNgamma, and inhibition of Th-2 derived cytokine, IL-4.	Quercetin	72-81	interferon gamma	Homo sapiens	146-154
12431781-9	2002	These results suggest that the beneficial immuno-stimulatory effects of quercetin may be mediated through the induction of Th-1 derived cytokine, IFNgamma, and inhibition of Th-2 derived cytokine, IL-4.	Quercetin	72-81	interleukin 4	Homo sapiens	197-201
12427482-2	2002	Quercetin is an inhibitor of CYP3A4 and a modulator of Pgp.	Quercetin	0-9	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	55-58
12427482-8	2002	A study using the everted intestinal sac was carried out to evaluate the effect of quercetin on the function of intestinal Pgp.	Quercetin	83-92	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	123-126
12427482-10	2002	However, the inverted sac study showed that quercetin significantly inhibited the function of intestinal Pgp.	Quercetin	44-53	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	105-108
12427482-11	2002	It is suggested that concurrent use of quercetin or quercetin-containing dietary supplement or herbs with cyclosporin or other medications whose absorption and metabolism are mediated by Pgp and/or CYP3A4 should require close monitoring.	Quercetin	39-48	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	187-190
12427482-11	2002	It is suggested that concurrent use of quercetin or quercetin-containing dietary supplement or herbs with cyclosporin or other medications whose absorption and metabolism are mediated by Pgp and/or CYP3A4 should require close monitoring.	Quercetin	52-61	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	187-190
14691983-3	2003	Furthermore, when a combination of Trp-P-2 with either quercitin or kaempferol was compared, the responses to Trp-P-2 were reduced to untreated control levels at the highest doses of quercitin and kaempferol.	Quercetin	55-64	polycystin 2, transient receptor potential cation channel	Homo sapiens	110-117
14691983-3	2003	Furthermore, when a combination of Trp-P-2 with either quercitin or kaempferol was compared, the responses to Trp-P-2 were reduced to untreated control levels at the highest doses of quercitin and kaempferol.	Quercetin	183-192	polycystin 2, transient receptor potential cation channel	Homo sapiens	35-42
14691983-3	2003	Furthermore, when a combination of Trp-P-2 with either quercitin or kaempferol was compared, the responses to Trp-P-2 were reduced to untreated control levels at the highest doses of quercitin and kaempferol.	Quercetin	183-192	polycystin 2, transient receptor potential cation channel	Homo sapiens	110-117
12508355-6	2003	RESULTS: Quercetin was found to suppress proliferation of human HCC cell lines BEL-7402, HuH-7 and HLE, with peak suppression at 50 micromol/L quercetin.	Quercetin	9-18	MIR7-3 host gene	Homo sapiens	89-94
12508355-6	2003	RESULTS: Quercetin was found to suppress proliferation of human HCC cell lines BEL-7402, HuH-7 and HLE, with peak suppression at 50 micromol/L quercetin.	Quercetin	143-152	MIR7-3 host gene	Homo sapiens	89-94
12445814-2	2002	In this communication, we report for the first time a study on the interactions of quercetin with the plasma protein human serum albumin (HSA), exploiting the intrinsic fluorescence emission properties of quercetin as a probe.	Quercetin	83-92	albumin	Homo sapiens	123-136
12445814-2	2002	In this communication, we report for the first time a study on the interactions of quercetin with the plasma protein human serum albumin (HSA), exploiting the intrinsic fluorescence emission properties of quercetin as a probe.	Quercetin	205-214	albumin	Homo sapiens	123-136
12150856-4	2002	In addition, several flavonoids, that is apigenin, luteolin, diosmetin, fisetin, and quercetin, inhibited the antigen-IgE-mediated TNF-alpha and IL-4 production from RBL-2H3 cells, both of which participate in the late phase of type I allergic reactions.	Quercetin	85-94	tumor necrosis factor	Rattus norvegicus	131-140
12391264-0	2002	The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells.	Quercetin	124-133	androgen receptor	Homo sapiens	11-28
12429348-1	2002	The present study was designed to investigate the correlation between the expression level of Hsp27 and Hsp72 and induction of apoptosis in HeLa cells in response to quercetin treatment.	Quercetin	166-175	heat shock protein family B (small) member 1	Homo sapiens	94-99
12429348-1	2002	The present study was designed to investigate the correlation between the expression level of Hsp27 and Hsp72 and induction of apoptosis in HeLa cells in response to quercetin treatment.	Quercetin	166-175	heat shock protein family A (Hsp70) member 1A	Homo sapiens	104-109
12429348-3	2002	Inhibition of the expression of Hsp72 and Hsp27 in tumour cells by anti-sense oligonucleotides, enhanced the induction of apoptosis by quercetin.	Quercetin	135-144	heat shock protein family A (Hsp70) member 1A	Homo sapiens	32-37
12429348-3	2002	Inhibition of the expression of Hsp72 and Hsp27 in tumour cells by anti-sense oligonucleotides, enhanced the induction of apoptosis by quercetin.	Quercetin	135-144	heat shock protein family B (small) member 1	Homo sapiens	42-47
12415562-14	2002	In addition, SOD, CAT, and GPx activities in renal cortex and erythrocytes of quercetin-treated animals were enhanced compared to animals of the IR group.	Quercetin	78-87	catalase	Rattus norvegicus	18-21
12150856-4	2002	In addition, several flavonoids, that is apigenin, luteolin, diosmetin, fisetin, and quercetin, inhibited the antigen-IgE-mediated TNF-alpha and IL-4 production from RBL-2H3 cells, both of which participate in the late phase of type I allergic reactions.	Quercetin	85-94	interleukin 4	Rattus norvegicus	145-149
12216835-0	2002	Intestinal apolipoprotein B secretion is inhibited by the flavonoid quercetin: potential role of microsomal triglyceride transfer protein and diacylglycerol acyltransferase.	Quercetin	68-77	apolipoprotein B	Homo sapiens	11-27
12227197-0	2002	Induction of neutral endopeptidase and angiotensin-converting enzyme activity of SK-N-SH cells in vitro by quercetin and resveratrol.	Quercetin	107-116	membrane metalloendopeptidase	Homo sapiens	13-34
12227197-0	2002	Induction of neutral endopeptidase and angiotensin-converting enzyme activity of SK-N-SH cells in vitro by quercetin and resveratrol.	Quercetin	107-116	hedgehog acyltransferase	Homo sapiens	81-85
12227197-1	2002	Quercetin and resveratrol are weak inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) activity of the neuroblastoma cell line SK-N-SH.	Quercetin	0-9	membrane metalloendopeptidase	Homo sapiens	49-70
12227197-1	2002	Quercetin and resveratrol are weak inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) activity of the neuroblastoma cell line SK-N-SH.	Quercetin	0-9	membrane metalloendopeptidase	Homo sapiens	72-75
12227197-1	2002	Quercetin and resveratrol are weak inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) activity of the neuroblastoma cell line SK-N-SH.	Quercetin	0-9	angiotensin I converting enzyme	Homo sapiens	112-115
12227197-1	2002	Quercetin and resveratrol are weak inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) activity of the neuroblastoma cell line SK-N-SH.	Quercetin	0-9	hedgehog acyltransferase	Homo sapiens	157-161
12227197-2	2002	The long term incubation of the cells for 4 days with quercetin, resveratrol and a combination of both substances in concentrations lower than necessary for inhibition of NEP and ACE activity induced the cellular enzyme activity of NEP and ACE associated with an inhibition of cellular proliferation.	Quercetin	54-63	membrane metalloendopeptidase	Homo sapiens	171-174
12227197-2	2002	The long term incubation of the cells for 4 days with quercetin, resveratrol and a combination of both substances in concentrations lower than necessary for inhibition of NEP and ACE activity induced the cellular enzyme activity of NEP and ACE associated with an inhibition of cellular proliferation.	Quercetin	54-63	angiotensin I converting enzyme	Homo sapiens	179-182
12227197-2	2002	The long term incubation of the cells for 4 days with quercetin, resveratrol and a combination of both substances in concentrations lower than necessary for inhibition of NEP and ACE activity induced the cellular enzyme activity of NEP and ACE associated with an inhibition of cellular proliferation.	Quercetin	54-63	membrane metalloendopeptidase	Homo sapiens	232-235
12227197-2	2002	The long term incubation of the cells for 4 days with quercetin, resveratrol and a combination of both substances in concentrations lower than necessary for inhibition of NEP and ACE activity induced the cellular enzyme activity of NEP and ACE associated with an inhibition of cellular proliferation.	Quercetin	54-63	angiotensin I converting enzyme	Homo sapiens	240-243
12050565-9	2002	All 11 of the 28 patients treated with the anti-inflammatory quercetin in whom treatment failed had the low TNF-alpha genotype versus 29.4% of those in whom treatment succeeded (p = 0.0003).	Quercetin	61-70	tumor necrosis factor	Homo sapiens	108-117
12050565-10	2002	Similarly men with quercetin treatment failure were much less likely to have the low IL-10 genotype than those with treatment success (9.1% versus 47.1%, p = 0.04).	Quercetin	19-28	interleukin 10	Homo sapiens	85-90
12206678-6	2002	Absorption studies show that a LDL particle has the capacity to bind approximately 10 quercetin molecules through interaction with apolipoprotein B.	Quercetin	86-95	apolipoprotein B	Homo sapiens	131-147
12237244-6	2002	Inhibition of AR expression could be achieved by potential chemopreventive agents flufenamic acid, resveratrol, quercetin, polyunsaturated fatty acids and interleukin-1beta, and by the application of AR antisense oligonucleotides.	Quercetin	112-121	androgen receptor	Homo sapiens	14-16
12237812-0	2002	Effect of quercetin on plasma extravasation in rat CNS and dura mater by ACE and NEP inhibition.	Quercetin	10-19	angiotensin I converting enzyme	Rattus norvegicus	73-76
12237812-0	2002	Effect of quercetin on plasma extravasation in rat CNS and dura mater by ACE and NEP inhibition.	Quercetin	10-19	membrane metallo-endopeptidase	Rattus norvegicus	81-84
12237812-7	2002	Quercetin-stimulated extravasation in all tissues was abolished by NK-1 receptor blockade.	Quercetin	0-9	tachykinin receptor 1	Rattus norvegicus	67-80
12237812-8	2002	These results suggest that quercetin increases PE in the dura mater and CNS tissues by inhibiting NEP and/or ACE, showing that the effect induced in the dura mater, cerebellum and cortex occurs through endogenous SP accumulation.	Quercetin	27-36	membrane metallo-endopeptidase	Rattus norvegicus	98-101
12237812-8	2002	These results suggest that quercetin increases PE in the dura mater and CNS tissues by inhibiting NEP and/or ACE, showing that the effect induced in the dura mater, cerebellum and cortex occurs through endogenous SP accumulation.	Quercetin	27-36	angiotensin I converting enzyme	Rattus norvegicus	109-112
12174832-0	2002	Inhibition of angiotesin-converting enzyme by quercetin alters the vascular response to brandykinin and angiotensin I.	Quercetin	46-55	angiotensinogen	Homo sapiens	104-117
12174832-3	2002	Quercetin pre-treatment (88.7 micromol/kg p.o., 45 min; 14.7 micromol/kg i.v., 5 min) significantly potentiated the hypotensive effect of bradykinin (10 nmol/kg i.v.).	Quercetin	0-9	kininogen 1	Homo sapiens	138-148
12105943-4	2002	The flavonol quercetin inhibited TNF-alpha production, but kaempferol and myricetin induced the secretion of TNF-alpha.	Quercetin	13-22	tumor necrosis factor	Homo sapiens	33-42
12086683-8	2002	Incubation with 3,5-dinitrocatechol (10 microM), a catechol-O-methyltransferase (COMT) inhibitor, prevented the conversion of quercetin to 3"-O-methyl quercetin.	Quercetin	126-135	catechol-O-methyltransferase	Rattus norvegicus	51-79
12086683-8	2002	Incubation with 3,5-dinitrocatechol (10 microM), a catechol-O-methyltransferase (COMT) inhibitor, prevented the conversion of quercetin to 3"-O-methyl quercetin.	Quercetin	126-135	catechol-O-methyltransferase	Rattus norvegicus	81-85
12086683-10	2002	The results demonstrate that in the rat lens COMT methylates quercetin and that the product accumulates within the lens.	Quercetin	61-70	catechol-O-methyltransferase	Rattus norvegicus	45-49
12086683-12	2002	Incubation of lenses with quercetin in the presence of COMT inhibitor revealed that the efficacy of quercetin is not dependent on its metabolism to 3"-O-methyl quercetin.	Quercetin	26-35	catechol-O-methyltransferase	Rattus norvegicus	55-59
12086683-12	2002	Incubation of lenses with quercetin in the presence of COMT inhibitor revealed that the efficacy of quercetin is not dependent on its metabolism to 3"-O-methyl quercetin.	Quercetin	100-109	catechol-O-methyltransferase	Rattus norvegicus	55-59
12216835-4	2002	Differentiated postconfluent CaCo-2 cells grown on filters and pretreated with quercetin for 8 h were shown by ELISA to inhibit basolateral apoB secretion in a dose-dependent manner.	Quercetin	79-88	apolipoprotein B	Homo sapiens	140-144
12216835-8	2002	Quercetin inhibited TAG synthesis under both basal and lipid-rich conditions, indicating that lipid availability is a determining factor in the regulation of apoB secretion by quercetin.	Quercetin	0-9	apolipoprotein B	Homo sapiens	158-162
12216835-8	2002	Quercetin inhibited TAG synthesis under both basal and lipid-rich conditions, indicating that lipid availability is a determining factor in the regulation of apoB secretion by quercetin.	Quercetin	176-185	apolipoprotein B	Homo sapiens	158-162
12216835-11	2002	Quercetin decreased MTP activity moderately.	Quercetin	0-9	microsomal triglyceride transfer protein	Homo sapiens	20-23
12216835-12	2002	In summary, the data demonstrated that pharmacological concentrations of quercetin are a potent inhibitor of intestinal apoB secretion and that reduced lipid availability and lipidation in the lipoprotein assembly step are the mechanism for the suppression of apoB-containing lipoprotein secretion by quercetin in CaCo-2 cells.	Quercetin	73-82	apolipoprotein B	Homo sapiens	120-124
12216835-12	2002	In summary, the data demonstrated that pharmacological concentrations of quercetin are a potent inhibitor of intestinal apoB secretion and that reduced lipid availability and lipidation in the lipoprotein assembly step are the mechanism for the suppression of apoB-containing lipoprotein secretion by quercetin in CaCo-2 cells.	Quercetin	73-82	apolipoprotein B	Homo sapiens	260-264
12216835-12	2002	In summary, the data demonstrated that pharmacological concentrations of quercetin are a potent inhibitor of intestinal apoB secretion and that reduced lipid availability and lipidation in the lipoprotein assembly step are the mechanism for the suppression of apoB-containing lipoprotein secretion by quercetin in CaCo-2 cells.	Quercetin	301-310	apolipoprotein B	Homo sapiens	260-264
12216835-3	2002	The purpose of our study was to examine the effects of quercetin, a common dietary flavonoid, on TAG and apoB secretion in a human intestinal cell-line, CaCo-2.	Quercetin	55-64	apolipoprotein B	Homo sapiens	105-109
11834736-9	2002	Quercetin was a potent non-competitive inhibitor of GLUT2 expressed in Xenopus oocytes; K(i) 22.8 microm.	Quercetin	0-9	solute carrier family 2 member 2 S homeolog	Xenopus laevis	52-57
12134086-12	2002	Importantly, quercetin and vitamin E, two antioxidant agents, successfully prevent the premature senescent phenotype and the up-regulation of caveolin-1 induced by hydrogen peroxide.	Quercetin	13-22	caveolin 1, caveolae protein	Mus musculus	142-152
12098601-9	2002	A decrease in iNOS protein, but not cyclooxygenase-2 protein, was detected in liver and lung specimens of lipopolysaccharide-treated Balb/c mice in the presence of rutin, wogonin or quercetin.	Quercetin	182-191	nitric oxide synthase 2, inducible	Mus musculus	14-18
12098601-10	2002	In conclusion, data obtained both in vitro and in vivo suggest that wogonin and quercetin exert inhibitory activity on lipopolysaccharide-induced NO production through suppression of iNOS expression.	Quercetin	80-89	nitric oxide synthase 2, inducible	Mus musculus	183-187
12098601-3	2002	In vitro results showed that wogonin and quercetin dose-dependently suppressed lipopolysaccharide-induced NO production in RAW 264.7 macrophages and primary peritoneal macrophages without a notable cytotoxic effect on either cell types associated with a decrease in inducible nitric oxide synthase (iNOS) protein expression in both cells.	Quercetin	41-50	nitric oxide synthase 2, inducible	Mus musculus	266-297
12098601-3	2002	In vitro results showed that wogonin and quercetin dose-dependently suppressed lipopolysaccharide-induced NO production in RAW 264.7 macrophages and primary peritoneal macrophages without a notable cytotoxic effect on either cell types associated with a decrease in inducible nitric oxide synthase (iNOS) protein expression in both cells.	Quercetin	41-50	nitric oxide synthase 2, inducible	Mus musculus	299-303
12054679-1	2002	We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation.	Quercetin	28-37	angiotensinogen	Rattus norvegicus	90-104
12054679-1	2002	We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation.	Quercetin	28-37	angiotensinogen	Rattus norvegicus	106-112
12054679-1	2002	We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation.	Quercetin	28-37	mitogen-activated protein kinase 8	Rattus norvegicus	195-218
12054679-1	2002	We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation.	Quercetin	28-37	mitogen-activated protein kinase 8	Rattus norvegicus	220-223
12018987-2	2002	In the present study, the regioselectivity of phase II biotransformation of the model flavonoids luteolin and quercetin by UDP-glucuronosyltransferases was investigated.	Quercetin	110-119	beta-1,3-glucuronyltransferase 2	Homo sapiens	123-151
12168845-1	2002	To glean insights into the mechanism of their action, we assessed the effects of two flavonoids, quercetin (Qu) and luteolin (Lu), on the growth and epidermal growth factor receptor (EGFR) tyrosine kinase activity of MiaPaCa-2 cancer cells.	Quercetin	97-106	epidermal growth factor receptor	Homo sapiens	149-181
12168845-0	2002	Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells.	Quercetin	77-86	epidermal growth factor receptor	Homo sapiens	16-48
12018987-9	2002	Qualitative comparison of the regioselectivities of glucuronidation obtained with human intestine and liver microsomes to those obtained with human UGT isoenzymes indicates that, in human liver, especially UGT1A9 and, in intestine, UGT1A1 and UGT1A8 are involved in glucuronidation of quercetin and luteolin.	Quercetin	285-294	beta-1,3-glucuronyltransferase 2	Homo sapiens	148-151
12098884-5	2002	The hepatic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity was significantly lowered by the quercetin dihydrate when compared to the other groups, while the hepatic acyl CoA: cholesterol acyltransferase (ACAT) activity was only significantly higher in the control group.	Quercetin	105-124	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	12-62
12144868-0	2002	Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line.	Quercetin	54-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	18-23
12021531-9	2002	Quercetin treatment suppressed the JNK activity and ameliorated apoptosis induced by H2O2.	Quercetin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	35-38
12021531-11	2002	Quercetin treatment could decrease JNK activity and ameliorate H2O2-induced apoptosis.	Quercetin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	35-38
12144868-9	2002	Taken together, our data indicated that amentoflavone and quercetin differentially exerted supression of PGE(2) biosynthesis via downregulation of COX-2/iNOS expression.	Quercetin	58-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
12144868-9	2002	Taken together, our data indicated that amentoflavone and quercetin differentially exerted supression of PGE(2) biosynthesis via downregulation of COX-2/iNOS expression.	Quercetin	58-67	nitric oxide synthase 2	Homo sapiens	153-157
12144868-0	2002	Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line.	Quercetin	54-63	nitric oxide synthase 2	Homo sapiens	28-32
12144868-3	2002	In the present study, we demonstrate the potential effects of different flavonoids on cytokines mediated cyclooxygenase-2 and inducible nitric oxide synthase expression and activities in A549 cell line using quercetin, amentoflavone and flavanone.	Quercetin	208-217	prostaglandin-endoperoxide synthase 2	Homo sapiens	105-121
12144868-6	2002	In another set of experiment, quercetin inhibited iNOS protein expression completely without affecting iNOS mRNA expression.	Quercetin	30-39	nitric oxide synthase 2	Homo sapiens	50-54
12054621-0	2002	The dietary flavonoid quercetin modulates HIF-1 alpha activity in endothelial cells.	Quercetin	22-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-53
12065059-0	2002	Inhibition of phenol sulfotransferase (SULT1A1) by quercetin in human adult and foetal livers.	Quercetin	51-60	sulfotransferase family 1A member 1	Homo sapiens	39-46
12065059-3	2002	The aim was to study the type of inhibition of SULT1A1 by quercetin in the human adult and foetal livers.	Quercetin	58-67	sulfotransferase family 1A member 1	Homo sapiens	47-54
12065059-10	2002	The IC(50) of quercetin for SULT1A1 was measured in three samples of adult and foetal livers and was 13 +/- 2.1 and 12 +/- 1.4 nM, respectively.	Quercetin	14-23	sulfotransferase family 1A member 1	Homo sapiens	28-35
12065059-17	2002	In conclusion, quercetin is a potent inhibitor of human adult and foetal liver SULT1A1.	Quercetin	15-24	sulfotransferase family 1A member 1	Homo sapiens	79-86
12065059-19	2002	This suggests that quercetin may inhibit the sulfation rate of those drugs sulphated by SULT1A1.	Quercetin	19-28	sulfotransferase family 1A member 1	Homo sapiens	88-95
12054621-6	2002	We report here that the dietary flavonoid quercetin also activates HIF-1 alpha in all steps of its activation pathway, in a manner similar to hypoxia.	Quercetin	42-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-78
12054621-7	2002	We found that quercetin, an inhibitor of Ser/Thr kinases, stabilises HIF-1 alpha and causes nuclear localisation of the protein in a transcriptionally active state.	Quercetin	14-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-80
12054621-8	2002	Taken together these results strongly indicate that the dietary flavonoid quercetin regulates HIF-1 function at normal oxygen concentrations.	Quercetin	74-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-99
11920648-6	2002	In vitro quercetin and trans-resveratrol, but not rutin, markedly enhanced apoptosis, causing mitochondrial depolarization and cytochrome c release followed by caspase-3 activation.	Quercetin	9-18	caspase 3	Mus musculus	160-169
11920648-7	2002	In addition, the effect of a combination of quercetin and trans-resveratrol on mitochondrial cytochrome c release and caspase-3 activity was greater than the expected additive response.	Quercetin	44-53	caspase 3	Mus musculus	118-127
11931710-0	2002	Effect of semi-synthesized quercetin water-soluble derivatives on recombinant human phosphatidylinositol 3-kinase p110beta catalytic subunit.	Quercetin	27-36	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	84-113
11931710-0	2002	Effect of semi-synthesized quercetin water-soluble derivatives on recombinant human phosphatidylinositol 3-kinase p110beta catalytic subunit.	Quercetin	27-36	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	114-122
11893605-6	2002	The same treatment resulted in increased gene and protein expression of IL-6, a response that was blocked by quercetin.	Quercetin	109-118	interleukin 6	Homo sapiens	72-76
11931710-1	2002	AIM: To study the effect of semi-synthesized quercetin water-soluble derivatives sodium quercetin-7-sulfate (SQMS) and disodium quercetin-7,4 -disulfate (SQDS) on recombinant human phosphatidylinositol 3-kinase (PI3-K) p110 beta catalytic subunit.	Quercetin	45-54	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	181-210
11867952-0	2002	Dietary quercetin augments activator protein-1 and does not reduce nuclear factor-kappa B in the renal cortex of rats with established chronic glomerular disease.	Quercetin	8-17	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-46
11902915-4	2002	The MIP achieved a capacity of 0.4 g quercetin per gram polymer and a recovery rate of 98.2%.	Quercetin	37-46	major intrinsic protein of lens fiber	Homo sapiens	4-7
11902915-9	2002	The MIP enabled the selective extraction of quercetin from a complex matrix, such as red wine, spiked with 8.8 mg per liter quercetin, demonstrating the potential of molecularly imprinted solid phase extraction for rapid, selective, and cost-effective sample pretreatment.	Quercetin	44-53	major intrinsic protein of lens fiber	Homo sapiens	4-7
11902915-9	2002	The MIP enabled the selective extraction of quercetin from a complex matrix, such as red wine, spiked with 8.8 mg per liter quercetin, demonstrating the potential of molecularly imprinted solid phase extraction for rapid, selective, and cost-effective sample pretreatment.	Quercetin	124-133	major intrinsic protein of lens fiber	Homo sapiens	4-7
11809535-1	2002	We investigated the effects of natural flavones, quercetin and morin, and their pentamethyl, pentaethyl, pentapropyl, pentabutyl and pentaallyl ethers, on the function of P-glycoprotein (P-gp) assessed by an increase in the uptake of [3H]vincristine by human myelogenous leukemia (K562) cells and adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.	Quercetin	49-58	ATP binding cassette subfamily B member 1	Homo sapiens	171-185
11877325-6	2002	In intact epithelium, quercetin induced an increase in short-circuit current (I(sc)), which was diminished by the Cl(-) channel blockers NPPB and DPC, but not by glibenclamide, DIDS or anthracene-9-carboxylic acid.	Quercetin	22-31	natriuretic peptide B	Rattus norvegicus	137-141
11920758-5	2002	Quercetin, an inhibitor for biosynthesis of heat shock protein 70 (HSP70), masked only the protective effect of L-Gln in both rat large intestine and Caco-2 cells.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	44-65
11920758-5	2002	Quercetin, an inhibitor for biosynthesis of heat shock protein 70 (HSP70), masked only the protective effect of L-Gln in both rat large intestine and Caco-2 cells.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	67-72
11967242-6	2002	Moreover, the inhibitory effects of estradiol were blocked in the presence of the CYP450 inhibitor 1-aminobenzotriazole and the catechol-O-methyltransferase inhibitors quercetin and OR486.	Quercetin	168-177	catechol-O-methyltransferase	Homo sapiens	128-156
12028662-5	2002	The glucuronides of quercetin and kaempferol formed upon incubation with rat hepatocytes were identified as the same ones formed after incubation with the UDP-glucuronosyltransferase isoform UGT1A9.	Quercetin	20-29	UDP glucuronosyltransferase family 1 member A9	Rattus norvegicus	191-197
11870780-0	2002	Inhibition of heat-induced phosphorylation of stathmin by the bioflavonoid quercetin.	Quercetin	75-84	stathmin 1	Homo sapiens	46-54
11835313-8	2002	These inhibitory effects were partially reversed by quercetin, a bioflavonoid which prevents HSF1 binding to DNA and thus attenuates the HSR.	Quercetin	52-61	heat shock transcription factor 1	Rattus norvegicus	93-97
11836020-1	2002	In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid compound arsenite.	Quercetin	186-195	ATP binding cassette subfamily C member 1	Homo sapiens	95-99
11836020-1	2002	In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid compound arsenite.	Quercetin	186-195	synaptonemal complex central element protein 1 like	Homo sapiens	104-108
11836020-1	2002	In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid compound arsenite.	Quercetin	186-195	nuclear receptor subfamily 1 group I member 2	Homo sapiens	235-254
11836020-1	2002	In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid compound arsenite.	Quercetin	186-195	nuclear receptor subfamily 1 group I member 2	Homo sapiens	256-259
11836020-5	2002	Reporter gene assays demonstrated that proximal promoter regions of the genes contribute to the induction by tBHQ, quercetin (MRP1) and clotrimazol (MRP2).	Quercetin	115-124	ATP binding cassette subfamily C member 1	Homo sapiens	126-130
11836020-5	2002	Reporter gene assays demonstrated that proximal promoter regions of the genes contribute to the induction by tBHQ, quercetin (MRP1) and clotrimazol (MRP2).	Quercetin	115-124	synaptonemal complex central element protein 1 like	Homo sapiens	149-153
11870780-1	2002	Effects of quercetin on heat-induced phosphorylation of stathmin in JURKAT cells were examined.	Quercetin	11-20	stathmin 1	Homo sapiens	56-64
11870780-4	2002	Immunoblot analysis of phosphorylated stathmin showed that heat-induced phosphorylation at Ser-38 was inhibited by quercetin but not by staurosporine.	Quercetin	115-124	stathmin 1	Homo sapiens	38-46
11870780-6	2002	These observations indicate that quercetin inhibits heat-induced phosphorylation at Ser-38 of stathmin but mitogen-activated protein (MAP) kinase is not involved in its phosphorylation.	Quercetin	33-42	stathmin 1	Homo sapiens	94-102
11882582-5	2002	Moreover, the inhibitory effects of estradiol were blocked by the CYP450 inhibitor 1-aminobenzotriazole (10 micromol/L) and the COMT inhibitors quercetin (10 micromol/L) and OR486 (10 micromol/L).	Quercetin	144-153	catechol-O-methyltransferase	Homo sapiens	128-132
11882582-8	2002	The abrogating effects of quercetin and OR486 on the metabolism and antimitogenic effects of 2-hydroxyestradiol were mimicked by 20 micromol/L norepinephrine and isoproterenol, substrates for COMT.	Quercetin	26-35	catechol-O-methyltransferase	Homo sapiens	192-196
11882583-7	2002	The growth inhibitory effects of estradiol were also blocked by quercetin (10 micromol/L) and OR 486 (10 micromol/L) inhibitors of catechol-O-methyltransferase (converts catecholestradiols to methoxyestradiols).	Quercetin	64-73	catechol-O-methyltransferase	Homo sapiens	131-159
11805197-8	2002	The inhibition of DEAQ formation by quercetin was competitive with K(i) values of 1.96 for CYP2C8 and 1.56 microM for HLMs.	Quercetin	36-45	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	91-97
11885806-0	2002	The effect of heat shock, cisplatin, etoposide and quercetin on Hsp27 expression in human normal and tumour cells.	Quercetin	51-60	heat shock protein family B (small) member 1	Homo sapiens	64-69
12191608-7	2002	In particular, the CK2alpha mutant V66A displays 27- and 11-fold higher IC(50) values with emodin and TBB, respectively, as compared with the wild-type, while the IC(50) value with quercetin is unchanged.	Quercetin	181-190	casein kinase 2 alpha 2	Homo sapiens	19-27
12015078-0	2002	[Study of the effects of quercetin on PML gene and protein expression and localization in leukemia cells].	Quercetin	25-34	PML nuclear body scaffold	Homo sapiens	38-41
11779194-9	2002	The effects of the proteasome inhibitors on C/EBP were inhibited by treating the cells with quercetin, a substance known to block the heat shock response.	Quercetin	92-101	CCAAT enhancer binding protein alpha	Homo sapiens	44-49
11885806-2	2002	Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin have an effect on the expression of heat shock protein 27 in tumour cells such as: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and also in normal human skin fibroblasts (HSF) cultured in two-dimensional (2D) and three-dimensional (3D) conditions.	Quercetin	95-104	heat shock protein family B (small) member 1	Homo sapiens	141-162
11885806-2	2002	Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin have an effect on the expression of heat shock protein 27 in tumour cells such as: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and also in normal human skin fibroblasts (HSF) cultured in two-dimensional (2D) and three-dimensional (3D) conditions.	Quercetin	95-104	interleukin 6	Homo sapiens	297-300
12242689-7	2002	In heart, catalase activity was increased in diabetic animals and restored to normal levels after combined treatment with quercetin and coenzyme Q(10).	Quercetin	122-131	catalase	Rattus norvegicus	10-18
11731719-4	2002	Upon treatment of cells with heat shock in the presence of quercetin, cell viability was significantly decreased 24 h after heat shock, with strong inhibition of HSP70 expression.	Quercetin	59-68	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	162-167
12672646-7	2002	To further elucidate whether inhibition of COF-induced DNA damage of quercetin is mediated through the inhibition of COX-2 gene expression by altering the nuclear factor-kappaB pathway, COX-2 mRNA and its protein expressions induced by COF were evaluated by reverse transcription-polymerase chain reaction and Western blot, respectively.	Quercetin	69-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	117-122
12672646-7	2002	To further elucidate whether inhibition of COF-induced DNA damage of quercetin is mediated through the inhibition of COX-2 gene expression by altering the nuclear factor-kappaB pathway, COX-2 mRNA and its protein expressions induced by COF were evaluated by reverse transcription-polymerase chain reaction and Western blot, respectively.	Quercetin	69-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	186-191
12672646-8	2002	Our data showed that COX-2 mRNA and protein levels were significantly repressed by addition of quercetin in a dose-dependent manner.	Quercetin	95-104	prostaglandin-endoperoxide synthase 2	Homo sapiens	21-26
11752233-4	2002	DNA damage measured as SB and DNA adducts was detectable in V79 r1A2-NH cells expressing rat CYP1A2 when treated with IQ (2.5-50 microM) and this was inhibited by quercetin.	Quercetin	163-172	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	93-99
11752233-5	2002	Likewise, DNA damage (SB and DNA adducts) was elevated in V79 h1A1-MZ cells expressing human CYP1A1 when treated with BaP (0.1-0.5 microM) and this was inhibited by chrysin and apigenin, but not by quercetin.	Quercetin	198-207	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
11752233-6	2002	The specificity of CYP1A1 inhibition by chrysin and apigenin and CYP1A2 inhibition by quercetin was confirmed by ethylresorufin O-deethylase assay.	Quercetin	86-95	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	65-71
11731719-5	2002	Rebamipide suppressed both cell death and a reduction in HSP70 induced by the combined treatment of heat shock and quercetin.	Quercetin	115-124	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	57-62
12476615-0	2002	The effect of cisplatin, etoposide and quercetin on Hsp72 expression.	Quercetin	39-48	heat shock protein family A (Hsp70) member 1A	Homo sapiens	52-57
12476615-2	2002	Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin influence the expression of heat shock protein 72 in tumour cells: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and normal human skin fibroblasts (HSF).	Quercetin	95-104	heat shock protein family A (Hsp70) member 1A	Homo sapiens	133-154
11749808-1	2001	AIM: To study the inhibitory effect of quercetin on cultured neonatal rat cardiomyocytes hypertrophy induced by angiotensin II (AngII) and its mechanism.	Quercetin	39-48	angiotensinogen	Rattus norvegicus	112-126
12476615-2	2002	Our study was designed to determine whether heat shock and drugs like cisplatin, etoposide and quercetin influence the expression of heat shock protein 72 in tumour cells: HeLa (cervical cancer), Hep-2 (larynx cancer), A549 (lung cancer) and normal human skin fibroblasts (HSF).	Quercetin	95-104	interleukin 6	Homo sapiens	273-276
12476615-5	2002	Quercetin inhibited heat shock protein expression in Hep-2 cells but induced in HSF.	Quercetin	0-9	interleukin 6	Homo sapiens	80-83
12476615-7	2002	Quercetin inhibited Hsp72 expression in normal and tumour cells.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1A	Homo sapiens	20-25
11749808-1	2001	AIM: To study the inhibitory effect of quercetin on cultured neonatal rat cardiomyocytes hypertrophy induced by angiotensin II (AngII) and its mechanism.	Quercetin	39-48	angiotensinogen	Rattus norvegicus	128-133
11749808-9	2001	Que (1-100 micromol/L) could inhibit the increase of total protein content, incorporation of [14C]uridine and [3H]tyrosine, and PKC and TPK activities induced by Ang II in concentration-dependent manner.	Quercetin	0-3	angiotensinogen	Rattus norvegicus	162-168
11740261-5	2001	Quercetin (30 microM), a suppressor of HSP, and sodium arsenite (100 microM), an inducer of HSP, were used to regulate the expression of HSP70 in PMNLs, and oxidative activity and apoptosis in these cells were measured.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	137-142
11740261-9	2001	Administration of quercetin before sodium arsenite prevented the expression of HSP70, the increase in oxidative activity, and the inhibition of apoptosis.	Quercetin	18-27	heat shock protein family A (Hsp70) member 4	Homo sapiens	79-84
11561098-5	2001	However, the expected concomitant increase in intracellular acidification due to PEPT1-mediated cefixime/H+-cotransport was less pronounced in the presence of quercetin.	Quercetin	159-168	solute carrier family 15 member 1	Homo sapiens	81-86
11903689-6	2001	Quercetin has been reported to be an agent that inhibits hsp70 expression.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	57-62
11903689-12	2001	RESULTS: Treatment with quercetin alone resulted in an apparent decrease of hsp70-positive cells and an increase of subG1 cells in JCA-1 and LNcap cells.	Quercetin	24-33	heat shock protein family A (Hsp70) member 4	Homo sapiens	76-81
11903689-13	2001	Quercetin inhibited an increase of hsp70 expression after heat treatment and increased the number of subG1 cells with lower levels of hsp70 in JCA-1 and LNcap cells.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	35-40
11903689-13	2001	Quercetin inhibited an increase of hsp70 expression after heat treatment and increased the number of subG1 cells with lower levels of hsp70 in JCA-1 and LNcap cells.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	134-139
11903689-15	2001	CONCLUSION: These results suggest that quercetin may enhance heat-induced cytotoxicity in prostate cancer cell lines through the inhibition of hsp70 production.	Quercetin	39-48	heat shock protein family A (Hsp70) member 4	Homo sapiens	143-148
12199071-2	2001	It was established that preliminary quercetin administration prevened neutral proteinase activation and alpha-2-macroglobulin activity decreasing after 2 h of cobalt chloride influence.	Quercetin	36-45	alpha-2-macroglobulin	Rattus norvegicus	104-125
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	19-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	62-69
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	19-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-74
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	19-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	146-153
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	19-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	154-158
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	19-28	cyclin dependent kinase 1	Homo sapiens	190-194
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	19-28	cyclin B1	Homo sapiens	195-204
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	19-28	tumor protein p53	Homo sapiens	240-243
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	247-256	cyclin dependent kinase inhibitor 1A	Homo sapiens	146-153
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	247-256	cyclin dependent kinase 1	Homo sapiens	190-194
11562764-9	2001	Quercetin also induced significant apoptosis in MCF-7 cells in addition to cell cycle arrest, and the induction of apoptosis was markedly blocked by antisense p21CIP1/WAF1 expression.	Quercetin	0-9	cyclin dependent kinase inhibitor 1A	Homo sapiens	159-166
11562764-9	2001	Quercetin also induced significant apoptosis in MCF-7 cells in addition to cell cycle arrest, and the induction of apoptosis was markedly blocked by antisense p21CIP1/WAF1 expression.	Quercetin	0-9	cyclin dependent kinase inhibitor 1A	Homo sapiens	167-171
11562426-0	2001	Quercetin inhibits Shc- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells.	Quercetin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	67-90
11562426-0	2001	Quercetin inhibits Shc- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells.	Quercetin	0-9	angiotensinogen	Rattus norvegicus	105-119
11562426-6	2001	Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin.	Quercetin	47-78	angiotensinogen	Rattus norvegicus	0-6
11562426-7	2001	Ang II caused a rapid tyrosine phosphorylation of Src homology and collagen (Shc), which was inhibited by quercetin.	Quercetin	106-115	angiotensinogen	Rattus norvegicus	0-6
11562426-6	2001	Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin.	Quercetin	47-78	mitogen-activated protein kinase 8	Rattus norvegicus	15-18
11562426-8	2001	Quercetin also inhibited Ang II-induced Shc.p85 association and subsequent activation of phosphatidylinositol 3-kinase (PI3-K)/Akt pathway in RASMC.	Quercetin	0-9	angiotensinogen	Rattus norvegicus	25-31
11562426-6	2001	Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin.	Quercetin	80-89	angiotensinogen	Rattus norvegicus	0-6
11562426-8	2001	Quercetin also inhibited Ang II-induced Shc.p85 association and subsequent activation of phosphatidylinositol 3-kinase (PI3-K)/Akt pathway in RASMC.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	127-130
11562426-6	2001	Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin.	Quercetin	80-89	mitogen-activated protein kinase 8	Rattus norvegicus	15-18
11562426-9	2001	Furthermore, LY294002, a PI3-K inhibitor and a quercetin derivative, inhibited Ang II-induced JNK activation as well as Akt phosphorylation.	Quercetin	47-56	angiotensinogen	Rattus norvegicus	79-85
11562426-6	2001	Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin.	Quercetin	80-89	mitogen activated protein kinase 14	Rattus norvegicus	158-161
11562426-9	2001	Furthermore, LY294002, a PI3-K inhibitor and a quercetin derivative, inhibited Ang II-induced JNK activation as well as Akt phosphorylation.	Quercetin	47-56	mitogen-activated protein kinase 8	Rattus norvegicus	94-97
11562426-10	2001	Finally, Ang II-induced [(3)H]leucine incorporation was abolished by both quercetin and LY294002.	Quercetin	74-83	angiotensinogen	Rattus norvegicus	9-15
11562426-6	2001	Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin.	Quercetin	80-89	angiotensinogen	Rattus norvegicus	176-182
11562426-11	2001	These findings suggest that the preventing effect of quercetin on Ang II-induced VSMC hypertrophy are attributable, in part, to its inhibitory effect on Shc- and PI3-K-dependent JNK activation in VSMC.	Quercetin	53-62	angiotensinogen	Rattus norvegicus	66-72
11562426-6	2001	Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin.	Quercetin	204-213	angiotensinogen	Rattus norvegicus	0-6
11562426-11	2001	These findings suggest that the preventing effect of quercetin on Ang II-induced VSMC hypertrophy are attributable, in part, to its inhibitory effect on Shc- and PI3-K-dependent JNK activation in VSMC.	Quercetin	53-62	mitogen-activated protein kinase 8	Rattus norvegicus	178-181
11562426-6	2001	Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin.	Quercetin	204-213	mitogen-activated protein kinase 8	Rattus norvegicus	15-18
11562426-12	2001	Thus, inhibition of JNK by quercetin may imply its usefulness for the treatment of cardiovascular diseases relevant to VSMC growth.	Quercetin	27-36	mitogen-activated protein kinase 8	Rattus norvegicus	20-23
11414687-0	2001	Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase.	Quercetin	0-9	matrix metallopeptidase 1	Homo sapiens	19-45
11697193-4	2001	Also, .UH- is reduced by flavonoids, quercetin and rutin in CTAB micelles at rate constants of 6 x 10(6) M-1s-1 and 1 x 10(6) M-1s-1, respectively.	Quercetin	37-46	tumor associated calcium signal transducer 2	Homo sapiens	105-132
11502892-7	2001	Using chimeric proteins consisting of the hormone binding domains of ER alpha and ER beta fused to the Gal4 DNA binding domain, we have established that genistein and quercetin are full estrogenic agonists of both ER isoforms.	Quercetin	167-176	estrogen receptor 1	Homo sapiens	69-77
11502892-7	2001	Using chimeric proteins consisting of the hormone binding domains of ER alpha and ER beta fused to the Gal4 DNA binding domain, we have established that genistein and quercetin are full estrogenic agonists of both ER isoforms.	Quercetin	167-176	estrogen receptor 2	Homo sapiens	82-89
11506819-8	2001	The TIMP-1 gene transcription and plasma protein levels (311+/-70 ng/ml at baseline to 183+/-35 ng/ml post-supplementation, P&lt;0.05) of the subjects in this study were, however, significantly decreased following quercetin supplementation.	Quercetin	214-223	TIMP metallopeptidase inhibitor 1	Homo sapiens	4-10
11424089-4	2001	Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia.	Quercetin	32-41	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	75-78
11424089-4	2001	Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia.	Quercetin	32-41	interleukin 6	Homo sapiens	154-157
11424089-4	2001	Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia.	Quercetin	32-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	162-167
11424089-4	2001	Our finding that a bioflavonoid quercetin (QCT), a well known inhibitor of hsp gene expression, significantly inhibited the transcriptional activation of HSF and HIF-1 strongly suggests that QCT-sensitive molecule(s) is involved in the transcriptional activation of HSF and HIF-1 by hypoxia.	Quercetin	32-41	interleukin 6	Homo sapiens	266-269
11414687-0	2001	Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	101-138
11414687-2	2001	Since recent studies documented that disruption of atherosclerotic plaques is the key event triggering acute myocardial infarction, and vascular endothelium-derived matrix metalloproteinase-1 (MMP-1) contributes to plaque destabilization, we examined the effect of quercetin on MMP-1 expression in human vascular endothelial cells.	Quercetin	265-274	matrix metallopeptidase 1	Homo sapiens	193-198
11414687-3	2001	Our results showed that quercetin significantly inhibited basal and oxidized LDL (oxLDL)-stimulated MMP-1 expression.	Quercetin	24-33	matrix metallopeptidase 1	Homo sapiens	100-105
11414687-4	2001	Our data also indicated that extracellular signal-regulated kinase (ERK) mediated the basal and oxLDL-stimulated expression of MMP-1, and quercetin is a potent inhibitor of ERK, suggesting that quercetin may inhibit MMP-1 expression by blocking the ERK pathway.	Quercetin	138-147	mitogen-activated protein kinase 1	Homo sapiens	173-176
11414687-4	2001	Our data also indicated that extracellular signal-regulated kinase (ERK) mediated the basal and oxLDL-stimulated expression of MMP-1, and quercetin is a potent inhibitor of ERK, suggesting that quercetin may inhibit MMP-1 expression by blocking the ERK pathway.	Quercetin	138-147	matrix metallopeptidase 1	Homo sapiens	216-221
11414687-4	2001	Our data also indicated that extracellular signal-regulated kinase (ERK) mediated the basal and oxLDL-stimulated expression of MMP-1, and quercetin is a potent inhibitor of ERK, suggesting that quercetin may inhibit MMP-1 expression by blocking the ERK pathway.	Quercetin	138-147	mitogen-activated protein kinase 1	Homo sapiens	173-176
11414687-4	2001	Our data also indicated that extracellular signal-regulated kinase (ERK) mediated the basal and oxLDL-stimulated expression of MMP-1, and quercetin is a potent inhibitor of ERK, suggesting that quercetin may inhibit MMP-1 expression by blocking the ERK pathway.	Quercetin	194-203	mitogen-activated protein kinase 1	Homo sapiens	29-66
11414687-4	2001	Our data also indicated that extracellular signal-regulated kinase (ERK) mediated the basal and oxLDL-stimulated expression of MMP-1, and quercetin is a potent inhibitor of ERK, suggesting that quercetin may inhibit MMP-1 expression by blocking the ERK pathway.	Quercetin	194-203	mitogen-activated protein kinase 1	Homo sapiens	68-71
11414687-4	2001	Our data also indicated that extracellular signal-regulated kinase (ERK) mediated the basal and oxLDL-stimulated expression of MMP-1, and quercetin is a potent inhibitor of ERK, suggesting that quercetin may inhibit MMP-1 expression by blocking the ERK pathway.	Quercetin	194-203	matrix metallopeptidase 1	Homo sapiens	127-132
11414687-4	2001	Our data also indicated that extracellular signal-regulated kinase (ERK) mediated the basal and oxLDL-stimulated expression of MMP-1, and quercetin is a potent inhibitor of ERK, suggesting that quercetin may inhibit MMP-1 expression by blocking the ERK pathway.	Quercetin	194-203	mitogen-activated protein kinase 1	Homo sapiens	173-176
11414687-4	2001	Our data also indicated that extracellular signal-regulated kinase (ERK) mediated the basal and oxLDL-stimulated expression of MMP-1, and quercetin is a potent inhibitor of ERK, suggesting that quercetin may inhibit MMP-1 expression by blocking the ERK pathway.	Quercetin	194-203	matrix metallopeptidase 1	Homo sapiens	216-221
11414687-4	2001	Our data also indicated that extracellular signal-regulated kinase (ERK) mediated the basal and oxLDL-stimulated expression of MMP-1, and quercetin is a potent inhibitor of ERK, suggesting that quercetin may inhibit MMP-1 expression by blocking the ERK pathway.	Quercetin	194-203	mitogen-activated protein kinase 1	Homo sapiens	173-176
11414687-6	2001	In conclusion, the present study demonstrated for the first time that quercetin inhibited MMP-1 expression in vascular endothelial cells, suggesting that quercetin might contribute to plaque stabilization.	Quercetin	70-79	matrix metallopeptidase 1	Homo sapiens	90-95
11414687-6	2001	In conclusion, the present study demonstrated for the first time that quercetin inhibited MMP-1 expression in vascular endothelial cells, suggesting that quercetin might contribute to plaque stabilization.	Quercetin	154-163	matrix metallopeptidase 1	Homo sapiens	90-95
11471985-3	2001	This study examined the use of Quercetin, a flavonoid drug shown previously to antagonize the expression of HSP72 and induce apoptosis as a sensitizer of prostate cancer growth in vivo.	Quercetin	31-40	heat shock protein family A (Hsp70) member 1A	Homo sapiens	108-113
11408351-4	2001	However, in cells transformed but non-tumorigenic, p53 protein is elevated and transcriptionally activated in response to quercetin or other DNA damaging stimuli, but the cells bypass quercetin-induced G1 arrest likely due to E7 expression.	Quercetin	122-131	tumor protein p53	Homo sapiens	51-54
11408351-4	2001	However, in cells transformed but non-tumorigenic, p53 protein is elevated and transcriptionally activated in response to quercetin or other DNA damaging stimuli, but the cells bypass quercetin-induced G1 arrest likely due to E7 expression.	Quercetin	184-193	tumor protein p53	Homo sapiens	51-54
11408351-5	2001	In transformed tumorigenic cells, p53 is elevated in response to quercetin but its transcriptional activity is inhibited due to mutation, and the cells fail to stop in G1 in the presence of quercetin.	Quercetin	65-74	tumor protein p53	Homo sapiens	34-37
11408351-5	2001	In transformed tumorigenic cells, p53 is elevated in response to quercetin but its transcriptional activity is inhibited due to mutation, and the cells fail to stop in G1 in the presence of quercetin.	Quercetin	190-199	tumor protein p53	Homo sapiens	34-37
11471985-4	2001	Quercetin dose-dependently suppressed PC-3 tumour growth in vitro and in vivo.	Quercetin	0-9	chromobox 8	Homo sapiens	38-42
11471985-5	2001	When combined in a treatment protocol with hyperthermia, quercetin drastically inhibited tumour growth and potently amplified the effects of hyperthermia on two prostate tumour types, PC-3 and DU-145 in vivo.	Quercetin	57-66	chromobox 8	Homo sapiens	184-188
12600108-4	2001	RESULTS: Compared with ox-VLDL group, Que and Iso decreased MDA production in a dependent concentration-manner, Que and Iso also elevated Vit E level and SOD activity markedly.	Quercetin	38-41	vitrin	Homo sapiens	138-141
11408547-7	2001	Quercetin, a flavonoid compound known to block As(III)-related induction of P-glycoprotein, was also found to prevent up-regulation of MRP2 gene expression in rat hepatocytes exposed to As(III).	Quercetin	0-9	ATP binding cassette subfamily C member 2	Rattus norvegicus	135-139
11318950-6	2001	The induction of HSP84 and HSP70 was blocked by pretreatment with quercetin.	Quercetin	66-75	heat shock protein 90 alpha family class B member 1	Rattus norvegicus	17-22
11333849-10	2001	In contrast, quercetin inhibited U937 cell adhesion to IL-1 beta-stimulated HAEC, whereas its metabolites were not effective.	Quercetin	13-22	interleukin 1 beta	Homo sapiens	55-64
11550050-2	2001	Lipoxygenase inhibitor salicylhydroxamic acid and antioxidants suppressing free radical reactions (ethyl gallate, alpha-tocopherol, astaxanthine, and quercetin) promoted conversion of beta-carotene into retinal catalyzed by beta-carotene-15,15"-dioxygenase.	Quercetin	150-159	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	0-12
11381056-6	2001	Quercetin, an inhibitor of Hsp expression was injected in the rats with heat stress (six rats) and zinc injection (seven rats).	Quercetin	0-9	selenoprotein K	Rattus norvegicus	27-30
11318950-6	2001	The induction of HSP84 and HSP70 was blocked by pretreatment with quercetin.	Quercetin	66-75	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	27-32
11442279-8	2001	Similarly, glucuronidation of quercetin was greatly increased in a UGT1A1-specific way.	Quercetin	30-39	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-73
11302779-7	2001	Flavonoids, particularly quercetin and its derivatives, are potent inhibitors of aldose reductase.	Quercetin	25-34	aldo-keto reductase family 1 member B	Homo sapiens	81-97
11259628-7	2001	On the other hand, inhibition of GST and GS-X pump by ethacrynic acid, quercetin, tannic acid, and indomethacin at concentrations that inhibited activities of GST and GS-X pump by more than 50% had no significant effects on cisplatin cytotoxicity and cisplatin-induced DNA ICL in these cells.	Quercetin	71-80	glutathione S-transferase kappa 1	Homo sapiens	33-36
11259628-7	2001	On the other hand, inhibition of GST and GS-X pump by ethacrynic acid, quercetin, tannic acid, and indomethacin at concentrations that inhibited activities of GST and GS-X pump by more than 50% had no significant effects on cisplatin cytotoxicity and cisplatin-induced DNA ICL in these cells.	Quercetin	71-80	ATP binding cassette subfamily C member 1	Homo sapiens	41-45
11259628-7	2001	On the other hand, inhibition of GST and GS-X pump by ethacrynic acid, quercetin, tannic acid, and indomethacin at concentrations that inhibited activities of GST and GS-X pump by more than 50% had no significant effects on cisplatin cytotoxicity and cisplatin-induced DNA ICL in these cells.	Quercetin	71-80	glutathione S-transferase kappa 1	Homo sapiens	159-162
11259628-7	2001	On the other hand, inhibition of GST and GS-X pump by ethacrynic acid, quercetin, tannic acid, and indomethacin at concentrations that inhibited activities of GST and GS-X pump by more than 50% had no significant effects on cisplatin cytotoxicity and cisplatin-induced DNA ICL in these cells.	Quercetin	71-80	ATP binding cassette subfamily C member 1	Homo sapiens	167-171
11238180-4	2001	To demonstrate that the repression effects on AR expression can actually reduce its function, we found that quercetin inhibited the secretion of the prostate-specific, androgen-regulated tumor markers, PSA and hK2.	Quercetin	108-117	RBPJ pseudogene 3	Homo sapiens	210-213
11238180-5	2001	The mRNA levels of androgen-regulated genes such as PSA, NKX3.1 as well as ornithine decarboxylase (ODC) were down-regulated by quercetin.	Quercetin	128-137	aminopeptidase puromycin sensitive	Homo sapiens	52-55
11238180-5	2001	The mRNA levels of androgen-regulated genes such as PSA, NKX3.1 as well as ornithine decarboxylase (ODC) were down-regulated by quercetin.	Quercetin	128-137	NK3 homeobox 1	Homo sapiens	57-63
11238180-5	2001	The mRNA levels of androgen-regulated genes such as PSA, NKX3.1 as well as ornithine decarboxylase (ODC) were down-regulated by quercetin.	Quercetin	128-137	ornithine decarboxylase 1	Homo sapiens	75-98
11238180-5	2001	The mRNA levels of androgen-regulated genes such as PSA, NKX3.1 as well as ornithine decarboxylase (ODC) were down-regulated by quercetin.	Quercetin	128-137	ornithine decarboxylase 1	Homo sapiens	100-103
11238180-6	2001	Transient transfections further showed that quercetin inhibited AR-mediated PSA expression at the transcription level.	Quercetin	44-53	androgen receptor	Homo sapiens	64-66
11238180-6	2001	Transient transfections further showed that quercetin inhibited AR-mediated PSA expression at the transcription level.	Quercetin	44-53	aminopeptidase puromycin sensitive	Homo sapiens	76-79
11238180-7	2001	Finally, it was demonstrated that quercetin could repress the expression of the AR gene at the transcription level.	Quercetin	34-43	androgen receptor	Homo sapiens	80-82
11238180-8	2001	Our result suggests that quercetin can attenuate the function of AR by repressing its expression and has the potential to become a chemopreventive and/or chemotherapeutic agent for prostate cancer.	Quercetin	25-34	androgen receptor	Homo sapiens	65-67
11306701-8	2001	Quercetin inhibited the ATPase activity of purified reconstituted MRP1 but stimulated vanadate-induced trapping of 8-azido-alpha-[(32)P]ADP by MRP1.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	66-70
11306701-8	2001	Quercetin inhibited the ATPase activity of purified reconstituted MRP1 but stimulated vanadate-induced trapping of 8-azido-alpha-[(32)P]ADP by MRP1.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	143-147
11306701-10	2001	In intact MRP1-overexpressing cells, quercetin reduced vincristine resistance from 8.9- to 2.2-fold, whereas kaempferol and naringenin had no effect.	Quercetin	37-46	ATP binding cassette subfamily B member 1	Homo sapiens	10-14
11238180-0	2001	Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells.	Quercetin	0-9	androgen receptor	Homo sapiens	54-71
11238180-3	2001	Western blot analysis showed that AR protein expression was inhibited by quercetin in a dose-dependent manner.	Quercetin	73-82	androgen receptor	Homo sapiens	34-36
11238180-4	2001	To demonstrate that the repression effects on AR expression can actually reduce its function, we found that quercetin inhibited the secretion of the prostate-specific, androgen-regulated tumor markers, PSA and hK2.	Quercetin	108-117	androgen receptor	Homo sapiens	46-48
11238180-4	2001	To demonstrate that the repression effects on AR expression can actually reduce its function, we found that quercetin inhibited the secretion of the prostate-specific, androgen-regulated tumor markers, PSA and hK2.	Quercetin	108-117	aminopeptidase puromycin sensitive	Homo sapiens	202-205
11275421-0	2001	Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin.	Quercetin	89-98	crystallin zeta	Homo sapiens	27-49
11275421-9	2001	The increase in NQO1 transcription in response to quercetin suggests that dietary plant polyphenols can stimulate transcription of phase II detoxifying systems, potentially through an ARE-dependent mechanism.	Quercetin	50-59	NAD(P)H quinone dehydrogenase 1	Homo sapiens	16-20
11275421-0	2001	Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin.	Quercetin	89-98	NAD(P)H quinone dehydrogenase 1	Homo sapiens	51-55
11275421-5	2001	We have investigated the effect of quercetin on expression and enzymatic activity of one of the major phase II detoxification systems, NAD(P)H:quinone oxidoreductase (NQO1) in the MCF-7 human breast carcinoma cell line.	Quercetin	35-44	crystallin zeta	Homo sapiens	143-165
11275421-5	2001	We have investigated the effect of quercetin on expression and enzymatic activity of one of the major phase II detoxification systems, NAD(P)H:quinone oxidoreductase (NQO1) in the MCF-7 human breast carcinoma cell line.	Quercetin	35-44	NAD(P)H quinone dehydrogenase 1	Homo sapiens	167-171
11275421-6	2001	We show that treatment of MCF-7 cells for 24 h with 15 microM quercetin results in a twofold increase in NQO1 protein levels and enzyme activity, and a three- to fourfold increase in NQO1 mRNA expression.	Quercetin	62-71	NAD(P)H quinone dehydrogenase 1	Homo sapiens	105-109
11275421-6	2001	We show that treatment of MCF-7 cells for 24 h with 15 microM quercetin results in a twofold increase in NQO1 protein levels and enzyme activity, and a three- to fourfold increase in NQO1 mRNA expression.	Quercetin	62-71	NAD(P)H quinone dehydrogenase 1	Homo sapiens	183-187
11275421-7	2001	We found that when these cells were transiently transfected with a luciferase (Luc) reporter plasmid containing two copies of the antioxidant response element (ARE) of the human NQO1 gene linked to a minimal viral promoter, quercetin caused an approximately twofold increase in Luc activity.	Quercetin	224-233	NAD(P)H quinone dehydrogenase 1	Homo sapiens	178-182
11500943-7	2001	Co-culture of cells with the antioxidants quercetin, dimethyltiourea and N-acetyl cysteine abolished both the iron-induced oxidative damage and the iron-induced increase in calreticulin.	Quercetin	42-51	calreticulin	Homo sapiens	173-185
11213362-6	2001	Quercetin, galangin, apigenin, and naringenin markedly decreased PGE2 release and COX-2 expression in a concentration-dependent manner.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	82-87
11500931-0	2001	Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages.	Quercetin	140-149	prostaglandin-endoperoxide synthase 2	Mus musculus	96-112
11123379-4	2001	From the compounds tested luteolin and quercetin were the most potent in inhibiting cytokine production with an IC(50) of less than 1 and 5 microM for TNF-alpha release, respectively.	Quercetin	39-48	tumor necrosis factor	Mus musculus	151-160
11123379-3	2001	Pretreatment of RAW 264.7 with luteolin, luteolin-7-glucoside, quercetin, and the isoflavonoid genistein inhibited both the LPS-stimulated TNF-alpha and interleukin-6 release, whereas eriodictyol and hesperetin only inhibited TNF-alpha release.	Quercetin	63-72	toll-like receptor 4	Mus musculus	124-127
11753212-5	2001	The expression of inducible-type NO synthase (iNOS) was markedly down-regulated by quercetin.	Quercetin	83-92	nitric oxide synthase 2, inducible	Mus musculus	18-44
11753212-5	2001	The expression of inducible-type NO synthase (iNOS) was markedly down-regulated by quercetin.	Quercetin	83-92	nitric oxide synthase 2, inducible	Mus musculus	46-50
11753212-6	2001	Quercetin suppressed the release of free nuclear factor (NF)-kappaB by preventing degradation of IkappaB-alpha and IkappaB-beta.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	97-110
11753212-6	2001	Quercetin suppressed the release of free nuclear factor (NF)-kappaB by preventing degradation of IkappaB-alpha and IkappaB-beta.	Quercetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta	Mus musculus	115-127
11753212-7	2001	Moreover, quercetin blocked the phosphorylation of extracellular signal regulated kinase 1/2 (Erk 1/2), p38, and c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) and, further, the activity of tyrosine kinases in LPS-stimulated RAW cells.	Quercetin	10-19	mitogen-activated protein kinase 3	Mus musculus	51-92
11753212-7	2001	Moreover, quercetin blocked the phosphorylation of extracellular signal regulated kinase 1/2 (Erk 1/2), p38, and c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) and, further, the activity of tyrosine kinases in LPS-stimulated RAW cells.	Quercetin	10-19	mitogen-activated protein kinase 3	Mus musculus	94-101
11753212-7	2001	Moreover, quercetin blocked the phosphorylation of extracellular signal regulated kinase 1/2 (Erk 1/2), p38, and c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) and, further, the activity of tyrosine kinases in LPS-stimulated RAW cells.	Quercetin	10-19	mitogen-activated protein kinase 14	Mus musculus	104-107
11753212-7	2001	Moreover, quercetin blocked the phosphorylation of extracellular signal regulated kinase 1/2 (Erk 1/2), p38, and c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) and, further, the activity of tyrosine kinases in LPS-stimulated RAW cells.	Quercetin	10-19	mitogen-activated protein kinase 8	Mus musculus	172-180
11753212-9	2001	Taken together, these results indicate that the inhibitory action of quercetin on NO production in LPS- and/or IFN-gamma-stimulated macrophages might be due to abrogation of iNOS protein induction by impairment of a series of intracellular signal pathways.	Quercetin	69-78	interferon gamma	Mus musculus	111-120
11753212-9	2001	Taken together, these results indicate that the inhibitory action of quercetin on NO production in LPS- and/or IFN-gamma-stimulated macrophages might be due to abrogation of iNOS protein induction by impairment of a series of intracellular signal pathways.	Quercetin	69-78	nitric oxide synthase 2, inducible	Mus musculus	174-178
11123379-3	2001	Pretreatment of RAW 264.7 with luteolin, luteolin-7-glucoside, quercetin, and the isoflavonoid genistein inhibited both the LPS-stimulated TNF-alpha and interleukin-6 release, whereas eriodictyol and hesperetin only inhibited TNF-alpha release.	Quercetin	63-72	tumor necrosis factor	Mus musculus	139-148
11123379-3	2001	Pretreatment of RAW 264.7 with luteolin, luteolin-7-glucoside, quercetin, and the isoflavonoid genistein inhibited both the LPS-stimulated TNF-alpha and interleukin-6 release, whereas eriodictyol and hesperetin only inhibited TNF-alpha release.	Quercetin	63-72	tumor necrosis factor	Mus musculus	226-235
11759294-5	2001	Quercetin treatment, however, resulted in a moderate increase in Cip1/p21 with no change in Kip1/p27 and a decrease in CDK4 and cyclin D1.	Quercetin	0-9	cyclin dependent kinase inhibitor 1A	Homo sapiens	65-69
11115572-8	2001	Kinase inhibitors, quercetin and NDGA were found to block signals for the perinuclear accumulation of Cdc42.	Quercetin	19-28	cell division cycle 42	Homo sapiens	102-107
11759294-5	2001	Quercetin treatment, however, resulted in a moderate increase in Cip1/p21 with no change in Kip1/p27 and a decrease in CDK4 and cyclin D1.	Quercetin	0-9	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-73
11759294-5	2001	Quercetin treatment, however, resulted in a moderate increase in Cip1/p21 with no change in Kip1/p27 and a decrease in CDK4 and cyclin D1.	Quercetin	0-9	cyclin dependent kinase 4	Homo sapiens	119-123
11759294-5	2001	Quercetin treatment, however, resulted in a moderate increase in Cip1/p21 with no change in Kip1/p27 and a decrease in CDK4 and cyclin D1.	Quercetin	0-9	cyclin D1	Homo sapiens	128-137
11223893-10	2001	Responses to Trp-P-2 were reduced to untreated control levels at the highest doses of quercitin and kaempferol, and were highly significantly different by comparison with Trp-P-2 alone (P&lt;0.001).	Quercetin	86-95	polycystin 2, transient receptor potential cation channel	Homo sapiens	13-20
11053056-3	2000	The expression was suppressed by heparin and quercetin, the drugs with anti-AP-1 activities.	Quercetin	45-54	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-80
11104512-0	2000	Quercetin inhibits c-fos, heat shock protein, and glial fibrillary acidic protein expression in injured astrocytes.	Quercetin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-24
11104512-0	2000	Quercetin inhibits c-fos, heat shock protein, and glial fibrillary acidic protein expression in injured astrocytes.	Quercetin	0-9	glial fibrillary acidic protein	Homo sapiens	50-81
11104512-12	2000	Western blot analysis for GFAP indicated that quercetin significantly reduced the induction of GFAP in the scratch model.	Quercetin	46-55	glial fibrillary acidic protein	Homo sapiens	26-30
11104512-12	2000	Western blot analysis for GFAP indicated that quercetin significantly reduced the induction of GFAP in the scratch model.	Quercetin	46-55	glial fibrillary acidic protein	Homo sapiens	95-99
11020457-0	2000	Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway.	Quercetin	47-56	nitric oxide synthase 2, inducible	Mus musculus	100-131
11020457-5	2000	The polyphenols quercetin and resveratrol at a micromolar range suppressed iNOS gene expression and NO production, as determined by reverse transcription-polymerase chain reaction and nitrite assay.	Quercetin	16-25	nitric oxide synthase 2, inducible	Mus musculus	75-79
11078914-3	2000	Combinations of ERbeta ligands such as estradiol (E(2)), 17 epiestriol (17E(3)), quercetin (Q) with tamoxifen (TMX) showed marked growth inhibition.	Quercetin	81-90	estrogen receptor 2	Homo sapiens	16-22
11078914-3	2000	Combinations of ERbeta ligands such as estradiol (E(2)), 17 epiestriol (17E(3)), quercetin (Q) with tamoxifen (TMX) showed marked growth inhibition.	Quercetin	81-90	thioredoxin related transmembrane protein 1	Homo sapiens	111-114
11154737-8	2000	Flavones, including quercetin and benzo(a)pyrene, are known inhibitors of NQO2.	Quercetin	20-29	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	74-78
11205268-11	2000	These results suggested that it is dependent on the dose and exposure time of quercetin to induce apoptosis of U937 cells in vitro, to affect the cell cycle distribution and to regulate the expression of hsp27 and hsp70.	Quercetin	78-87	heat shock protein family B (small) member 1	Homo sapiens	204-209
11205268-8	2000	On exposure to 100 mM of quercetin, the inhibition of hsp27 and hsp70 expression was observed from 12 hours to 48 hours and 6 hours to 48 hours respectively.	Quercetin	25-34	heat shock protein family B (small) member 1	Homo sapiens	54-59
11041245-2	2000	It was found that (i) both bLF and hLF are GL-binding proteins; (ii) purified both proteins function as phosphate acceptors of CK-II; and (iii) this phosphorylation is completely inhibited by two polyphenol-containing anti-oxidant compounds (quercetin and epigallocatechin gallate) at I microm, whereas a glycyrrhetinic acid derivative (oGA) inhibits it at one tenth the concentration of GL.	Quercetin	242-251	HLF transcription factor, PAR bZIP family member	Homo sapiens	35-38
11205268-8	2000	On exposure to 100 mM of quercetin, the inhibition of hsp27 and hsp70 expression was observed from 12 hours to 48 hours and 6 hours to 48 hours respectively.	Quercetin	25-34	heat shock protein family A (Hsp70) member 4	Homo sapiens	64-69
11205268-9	2000	The inhibition of hsp90 expression was not found eiyher at 50 mM or 100 mM of quercetin exposure.	Quercetin	78-87	heat shock protein 90 alpha family class A member 1	Homo sapiens	18-23
11205268-11	2000	These results suggested that it is dependent on the dose and exposure time of quercetin to induce apoptosis of U937 cells in vitro, to affect the cell cycle distribution and to regulate the expression of hsp27 and hsp70.	Quercetin	78-87	heat shock protein family A (Hsp70) member 4	Homo sapiens	214-219
11090628-0	2000	Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.	Quercetin	89-98	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	27-52
11090628-2	2000	The X-ray crystallographic structures of PI3Kgamma bound to these lipid kinase inhibitors and to the broad-spectrum protein kinase inhibitors quercetin, myricetin, and staurosporine reveal how these compounds fit into the ATP binding pocket.	Quercetin	142-151	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	41-50
10972672-13	2000	CONCLUSIONS: These results suggested that (1) activation of JNK and ERKs, but not p38 kinase, is required for the H2O2-induced apoptosis; and (2) suppression of the JNK-c-Jun/AP-1 pathway and the ERK-c-Fos/AP-1 pathway is involved in the anti-apoptotic effect of quercetin.	Quercetin	263-272	mitogen-activated protein kinase 8	Homo sapiens	60-63
10964096-6	2000	Positive cyclin D(1) expression was detected in mice on diets supplemented either with quercetin (P: &lt; 0.01) or rutin (P: &lt; 0.05).	Quercetin	87-96	cyclin D1	Mus musculus	9-20
10972672-0	2000	Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways.	Quercetin	25-34	mitogen-activated protein kinase 8	Homo sapiens	56-59
10972672-0	2000	Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways.	Quercetin	25-34	mitogen-activated protein kinase 1	Homo sapiens	65-68
10958819-0	2000	Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration.	Quercetin	109-118	component of oligomeric golgi complex 2	Homo sapiens	137-166
10958819-9	2000	As a single component, quercetin was inversely correlated with both TC (r = -0.261, P: &lt; 0.01) and LDL-C (r = -0.	Quercetin	23-32	component of oligomeric golgi complex 2	Homo sapiens	102-107
10972672-13	2000	CONCLUSIONS: These results suggested that (1) activation of JNK and ERKs, but not p38 kinase, is required for the H2O2-induced apoptosis; and (2) suppression of the JNK-c-Jun/AP-1 pathway and the ERK-c-Fos/AP-1 pathway is involved in the anti-apoptotic effect of quercetin.	Quercetin	263-272	mitogen-activated protein kinase 3	Homo sapiens	68-72
10972672-1	2000	BACKGROUND: Bioflavonoid quercetin inhibits hydrogen peroxide (H2O2)-induced apoptosis via intervention in the activator protein 1 (AP-1)-mediated apoptotic pathway.	Quercetin	25-34	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-130
10972672-1	2000	BACKGROUND: Bioflavonoid quercetin inhibits hydrogen peroxide (H2O2)-induced apoptosis via intervention in the activator protein 1 (AP-1)-mediated apoptotic pathway.	Quercetin	25-34	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-136
10972672-13	2000	CONCLUSIONS: These results suggested that (1) activation of JNK and ERKs, but not p38 kinase, is required for the H2O2-induced apoptosis; and (2) suppression of the JNK-c-Jun/AP-1 pathway and the ERK-c-Fos/AP-1 pathway is involved in the anti-apoptotic effect of quercetin.	Quercetin	263-272	mitogen-activated protein kinase 8	Homo sapiens	165-168
10972672-13	2000	CONCLUSIONS: These results suggested that (1) activation of JNK and ERKs, but not p38 kinase, is required for the H2O2-induced apoptosis; and (2) suppression of the JNK-c-Jun/AP-1 pathway and the ERK-c-Fos/AP-1 pathway is involved in the anti-apoptotic effect of quercetin.	Quercetin	263-272	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	169-174
10972672-13	2000	CONCLUSIONS: These results suggested that (1) activation of JNK and ERKs, but not p38 kinase, is required for the H2O2-induced apoptosis; and (2) suppression of the JNK-c-Jun/AP-1 pathway and the ERK-c-Fos/AP-1 pathway is involved in the anti-apoptotic effect of quercetin.	Quercetin	263-272	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-179
10972672-13	2000	CONCLUSIONS: These results suggested that (1) activation of JNK and ERKs, but not p38 kinase, is required for the H2O2-induced apoptosis; and (2) suppression of the JNK-c-Jun/AP-1 pathway and the ERK-c-Fos/AP-1 pathway is involved in the anti-apoptotic effect of quercetin.	Quercetin	263-272	mitogen-activated protein kinase 1	Homo sapiens	68-71
11140816-12	2000	Exposure to TNF-alpha or quercetin was crucial for increased activity of NF-kappaB, which may implicate an increasing resistance to their cytotoxicity.	Quercetin	25-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82
10900049-5	2000	Phosphorylation of the MP was decreased by addition of kinase inhibitors such as heparin, suramin and quercetin, which are known to be effective for casein kinase II (CK II).	Quercetin	102-111	casein kinase 2 alpha 1	Homo sapiens	149-165
11140816-0	2000	Induction of apoptosis and NF-kappaB by quercetin in growing murine L1210 lymphocytic leukaemic cells potentiated by TNF-alpha.	Quercetin	40-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	27-36
11140816-0	2000	Induction of apoptosis and NF-kappaB by quercetin in growing murine L1210 lymphocytic leukaemic cells potentiated by TNF-alpha.	Quercetin	40-49	tumor necrosis factor	Mus musculus	117-126
11140816-3	2000	The above mentioned death promoting activity of quercetin was enhanced by physiological concentrations of TNF-alpha.	Quercetin	48-57	tumor necrosis factor	Mus musculus	106-115
11140816-9	2000	We conclude that quercetin unmasked cell death, promoting the activity of TNF-alpha.	Quercetin	17-26	tumor necrosis factor	Mus musculus	74-83
11501184-1	2000	AIM: To study the inhibitory effect of semi-synthesized quercetin derivatives--disodium quercetin-7,4"-disulfate (DQD) on the platelet aggregation induced by thrombin and its mechanism.	Quercetin	56-65	coagulation factor II, thrombin	Sus scrofa	158-166
10900049-5	2000	Phosphorylation of the MP was decreased by addition of kinase inhibitors such as heparin, suramin and quercetin, which are known to be effective for casein kinase II (CK II).	Quercetin	102-111	casein kinase 2 alpha 1	Homo sapiens	167-172
10965594-5	2000	In contrast to the natural compound quercetin, the compounds were more potent inhibiting cyclooxygenase-1 than 5-lipoxygenase except for 3-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one (5).	Quercetin	36-45	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	89-105
10925400-5	2000	The potential anti-carcinogenic effect of quercetin noted in this study is attributed to its antioxidant property which was reflected in the lipid peroxides and their role in the host detoxification system, as expressed in liver glutathione level, glutathione-S-transferase, glutathione peroxidase, catalase and superoxide dismutase activity.	Quercetin	42-51	catalase	Mus musculus	299-307
10965594-5	2000	In contrast to the natural compound quercetin, the compounds were more potent inhibiting cyclooxygenase-1 than 5-lipoxygenase except for 3-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one (5).	Quercetin	36-45	arachidonate 5-lipoxygenase	Rattus norvegicus	111-125
10718847-5	2000	RESULTS: Luteolin, baicalein and quercetin inhibited the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from HCMC in a concentration-dependent manner.	Quercetin	33-42	prostaglandin D2 synthase	Homo sapiens	99-115
10826917-8	2000	Other MPO systems inactivating LADH were (a) MPO/H2O2/chlorpromazine; (b) MPO/H2O2/monophenolic systems, including L-tyrosine, serotonin and acetaminophen and (c) MPO/H2O2/di- and polyphenolic systems, including norepinephrine, catechol, nordihydroguaiaretic acid, caffeic acid, quercetin and catechin.	Quercetin	279-288	myeloperoxidase	Sus scrofa	6-9
10880051-7	2000	The culture-induced enhanced HSP70 expression can be prevented by addition of either the flavonoid antioxidant quercetin or an antisense oligonucleotide to HSP70.	Quercetin	111-120	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	29-34
10880051-7	2000	The culture-induced enhanced HSP70 expression can be prevented by addition of either the flavonoid antioxidant quercetin or an antisense oligonucleotide to HSP70.	Quercetin	111-120	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	156-161
11070355-0	2000	Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells.	Quercetin	0-9	sulfotransferase family 1E member 1	Homo sapiens	42-67
10864017-9	2000	Flavonols, such as quercetin and kaempferol, inhibited the P-ST activity at low concentrations.	Quercetin	19-28	sulfotransferase family 1A member 1	Homo sapiens	59-63
10783318-7	2000	Chemopreventive agents such as quercetin, kaempferol, genistein, resveratrol and resorcinol, all having a common resorcin moiety, were found to effectively suppress the COX-2 promoter activity with and without TGFalpha-stimulation in DLD-1 cells.	Quercetin	31-40	prostaglandin-endoperoxide synthase 2	Homo sapiens	169-174
10783318-7	2000	Chemopreventive agents such as quercetin, kaempferol, genistein, resveratrol and resorcinol, all having a common resorcin moiety, were found to effectively suppress the COX-2 promoter activity with and without TGFalpha-stimulation in DLD-1 cells.	Quercetin	31-40	transforming growth factor alpha	Homo sapiens	210-218
10760502-0	2000	In vitro glucuronidation of kaempferol and quercetin by human UGT-1A9 microsomes.	Quercetin	43-52	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	62-69
10760502-3	2000	In this work, the in vitro glucuronidation of the common dietary flavonoids quercetin and kaempferol by human UDP-glucuronosyltransferase microsomes (UGT-1A9) was investigated using HPLC and LC-MS.	Quercetin	76-85	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	150-157
10718847-10	2000	The activation of extracellular signal-regulated kinases (ERKs) and c-Jun NH2-terminal kinase (JNK), that were activated just before the release of LTs and PGD2 and GM-CSF mRNA expression in IgE-mediated signal transduction events, were clearly suppressed by luteolin and quercetin.	Quercetin	272-281	mitogen-activated protein kinase 8	Homo sapiens	68-93
10718847-10	2000	The activation of extracellular signal-regulated kinases (ERKs) and c-Jun NH2-terminal kinase (JNK), that were activated just before the release of LTs and PGD2 and GM-CSF mRNA expression in IgE-mediated signal transduction events, were clearly suppressed by luteolin and quercetin.	Quercetin	272-281	mitogen-activated protein kinase 8	Homo sapiens	95-98
10718847-10	2000	The activation of extracellular signal-regulated kinases (ERKs) and c-Jun NH2-terminal kinase (JNK), that were activated just before the release of LTs and PGD2 and GM-CSF mRNA expression in IgE-mediated signal transduction events, were clearly suppressed by luteolin and quercetin.	Quercetin	272-281	colony stimulating factor 2	Homo sapiens	165-171
10976523-1	2000	Tyrosinase inhibitory activity of flavonols, galangin, kaempferol and quercetin, was found to come from their ability to chelate copper in the enzyme.	Quercetin	70-79	tyrosinase	Homo sapiens	0-10
10920275-2	2000	Investigation of the suppressive action of twelve flavonoids of different chemical classes on the transcriptional activity of the COX-2 gene in human colon cancer DLD-1 cells using a reporter gene assay have revealed quercetin to be the most potent suppressor of COX-2 transcription (IC50 = 10.5 microM), while catechin and epicatechin showed weak activity (IC50 = 415.3 microM).	Quercetin	217-226	prostaglandin-endoperoxide synthase 2	Homo sapiens	130-135
10920275-2	2000	Investigation of the suppressive action of twelve flavonoids of different chemical classes on the transcriptional activity of the COX-2 gene in human colon cancer DLD-1 cells using a reporter gene assay have revealed quercetin to be the most potent suppressor of COX-2 transcription (IC50 = 10.5 microM), while catechin and epicatechin showed weak activity (IC50 = 415.3 microM).	Quercetin	217-226	prostaglandin-endoperoxide synthase 2	Homo sapiens	263-268
10718847-5	2000	RESULTS: Luteolin, baicalein and quercetin inhibited the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from HCMC in a concentration-dependent manner.	Quercetin	33-42	colony stimulating factor 2	Homo sapiens	128-176
10718847-5	2000	RESULTS: Luteolin, baicalein and quercetin inhibited the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from HCMC in a concentration-dependent manner.	Quercetin	33-42	colony stimulating factor 2	Homo sapiens	178-184
10652438-0	2000	Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors.	Quercetin	0-9	H3 histone pseudogene 16	Homo sapiens	19-22
10995031-5	2000	Quercetin and epicatechin were the strongest inhibitors of LDL oxidation catalyzed by 15-lipoxygenase; ascorbic acid was an effective inhibitor in the first 3 h of oxidation; and fivefold alpha-tocopherol-enriched LDL showed a partial inhibition of CE-OOH formation only after 4-6 h of incubation.	Quercetin	0-9	arachidonate 15-lipoxygenase	Homo sapiens	86-101
10995031-9	2000	These results emphasize the inhibitory effect of the flavonoids quercetin and epicatechin on 15-lipoxygenase-mediated LDL lipid peroxidation.	Quercetin	64-73	arachidonate 15-lipoxygenase	Homo sapiens	93-108
10660112-1	2000	Treatment of Caco-2 cells with the antioxidants quercetin or t-butylhydroquinone led to induced protein levels of UDP-glucuronosyltransferase UGT1A6 (ca.	Quercetin	48-57	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	142-148
10652438-1	2000	Immunocytochemical studies have revealed that 10 microM quercetin reduced the steady state levels of p21-ras proteins in both colon cancer cell lines and primary colorectal tumors.	Quercetin	56-65	H3 histone pseudogene 16	Homo sapiens	101-104
10652438-2	2000	These findings were confirmed by Western blot and flow cytometric analysis showing that the inhibition of p21-ras expression by quercetin was time- and concentration-dependent.	Quercetin	128-137	H3 histone pseudogene 16	Homo sapiens	106-109
10652438-3	2000	Twenty-four-hour treatment with 10 microM quercetin reduced p21-ras levels to about 50% of control values.	Quercetin	42-51	H3 histone pseudogene 16	Homo sapiens	60-63
10652438-4	2000	Quercetin was similarly effective in inhibiting the expression of K-, H-, and N-ras proteins.	Quercetin	0-9	NRAS proto-oncogene, GTPase	Homo sapiens	78-83
10652438-6	2000	Northern blot analysis revealed that quercetin produced in colon cancer cells an early (30 min) reduction of the steady state levels of K-, H-, and N-ras mRNAs.	Quercetin	37-46	NRAS proto-oncogene, GTPase	Homo sapiens	148-153
10601582-2	2000	Genistein and quercetin inhibited cell growth with IC50 values of 8.8 and 18.1 muM, respectively, while the other phytoestrogens were less effective.	Quercetin	14-23	latexin	Homo sapiens	79-82
10620351-8	2000	Quercetin treatment alone slightly enhanced binding of AP-1 complexes to this site.	Quercetin	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-59
10706406-3	2000	Three polyphenol-containing anti-oxidant compounds [catechin, epigallocatechin gallate (EGCG) and quercetin] inhibited CK-II activity (phosphorylation of these ribosomal P proteins) in a dose-dependent manner in vitro.	Quercetin	98-107	casein kinase 2 alpha 1	Homo sapiens	119-124
11142097-3	2000	The proliferation of LNCaP and PC3 cells was preferentially inhibited by flavonoids (catechin, epicatechin, and quercetin), whereas resveratrol was the most potent inhibitor of DU145 cell growth.	Quercetin	112-121	BTG anti-proliferation factor 2	Homo sapiens	31-34
11341036-2	2000	Complete growth retardation was observed in PC-3 cells treated with 100 microM quercetin, kaempferol, and luteolin, while isomolar genistein, apigenin, and myricetin suppressed PC-3 proliferation by 73%, 70%, and 59%, respectively (p &lt; 0.05).	Quercetin	79-88	chromobox 8	Homo sapiens	44-48
11341036-2	2000	Complete growth retardation was observed in PC-3 cells treated with 100 microM quercetin, kaempferol, and luteolin, while isomolar genistein, apigenin, and myricetin suppressed PC-3 proliferation by 73%, 70%, and 59%, respectively (p &lt; 0.05).	Quercetin	79-88	chromobox 8	Homo sapiens	177-181
11341036-7	2000	The antiproliferative response of PC-3 cells to quercetin and kaempferol was additive when supplemented to the medium at 25 microM.	Quercetin	48-57	chromobox 8	Homo sapiens	34-38
11341036-11	2000	The present studies suggest that alterations in cell cycle progression contribute significantly to the antiproliferative effects of quercetin and kaempferol in PC-3 cells.	Quercetin	132-141	chromobox 8	Homo sapiens	160-164
11467774-0	2000	Quercetin inhibits the invasion and mobility of murine melanoma B16-BL6 cells through inducing apoptosis via decreasing Bcl-2 expression.	Quercetin	0-9	B cell leukemia/lymphoma 2	Mus musculus	120-125
11467774-6	2000	Furthermore, quercetin markedly inhibited the expression of anti-apoptotic protein Bcl-2 but hardly influenced Bcl-XL.	Quercetin	13-22	B cell leukemia/lymphoma 2	Mus musculus	83-88
11467774-7	2000	These results suggest that the inhibition of quercetin on invasiveness and migration of B16-BL6 cells are closely associated with the arrest of cell cycle as well as the induction of apoptosis by decreasing the Bcl-2 expression.	Quercetin	45-54	B cell leukemia/lymphoma 2	Mus musculus	211-216
11041272-6	2000	In HSP synthesis inhibitor quercetin-treated cells, HSP-70 expression was not enhanced after heat stress, and Ca2+ rise in response to 5-HT did not return to the control level.	Quercetin	27-36	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	52-58
10601582-7	2000	With 100 muM quercetin, 47% of the cells were apoptotic, while the other bioflavonoids had little effect.	Quercetin	13-22	latexin	Homo sapiens	9-12
10601582-9	2000	In contrast, the action of quercetin involved an increase in cyclin B1 level.	Quercetin	27-36	cyclin B1	Homo sapiens	61-70
10617062-0	1999	Effects of quercetin on the release of endothelin, prostacyclin and tissue plasminogen activator from human endothelial cells in culture.	Quercetin	11-20	chromosome 20 open reading frame 181	Homo sapiens	68-96
10604938-3	2000	Quercetin-treated RBL-2H3 cells in which expression of G(alphai2) and G(alphai3) is enhanced more than 7-fold respond to the G(i) stimulant compound 48/80 with the activation of PLD, a transient activation of phospholipase C, and enhanced membrane GTPase activity.	Quercetin	0-9	G protein subunit alpha i2	Rattus norvegicus	55-64
10805410-6	2000	Both the antihypotensive effects of adaptation and HSP70 accumulation were completely prevented by L-NNA, an inhibitor of NO synthesis, or quercetin, an inhibitor of HSP70 synthesis.	Quercetin	139-148	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	51-56
10805410-6	2000	Both the antihypotensive effects of adaptation and HSP70 accumulation were completely prevented by L-NNA, an inhibitor of NO synthesis, or quercetin, an inhibitor of HSP70 synthesis.	Quercetin	139-148	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	166-171
10590836-3	1999	As the cellular heat shock response also involves the activation of heat shock transcription factor (HSF), we have, in the present study, examined the role of HSF in the stress potentiation of GR by use of a flavonoid compound, quercetin, recently shown to selectively inhibit the stress response in a variety of human and murine cell lines.	Quercetin	228-237	interleukin 6	Homo sapiens	101-104
10590836-3	1999	As the cellular heat shock response also involves the activation of heat shock transcription factor (HSF), we have, in the present study, examined the role of HSF in the stress potentiation of GR by use of a flavonoid compound, quercetin, recently shown to selectively inhibit the stress response in a variety of human and murine cell lines.	Quercetin	228-237	interleukin 6	Homo sapiens	159-162
10590836-6	1999	In L929 cells stably transfected with a CAT reporter plasmid under the control of the HSF-responsive hsp70 promoter (LHSECAT cells), pretreatment with quercetin was found to cause a dose- and time-dependent inactivation of HSF activity following heat shock, but only when added before the stress event.	Quercetin	151-160	catalase	Mus musculus	40-43
10590836-6	1999	In L929 cells stably transfected with a CAT reporter plasmid under the control of the HSF-responsive hsp70 promoter (LHSECAT cells), pretreatment with quercetin was found to cause a dose- and time-dependent inactivation of HSF activity following heat shock, but only when added before the stress event.	Quercetin	151-160	interleukin 6	Homo sapiens	86-89
10590836-6	1999	In L929 cells stably transfected with a CAT reporter plasmid under the control of the HSF-responsive hsp70 promoter (LHSECAT cells), pretreatment with quercetin was found to cause a dose- and time-dependent inactivation of HSF activity following heat shock, but only when added before the stress event.	Quercetin	151-160	interleukin 6	Homo sapiens	223-226
10590836-7	1999	In LMCAT2 cells, quercetin similarly inhibited both heat and chemical shock potentiation of Dex-induced GR activity.	Quercetin	17-26	nuclear receptor subfamily 3, group C, member 1	Mus musculus	104-106
10590836-8	1999	This activity of quercetin was not the result of post-transcriptional or general cytotoxic properties, as quercetin (1) did not significantly affect GR or HSF activities when added after the stress event, (2) did not reduce CAT gene expression as controlled by the constitutive SV40 early promoter, and (3) did not alter normal (non-stress), Dex-induced MMTV-CAT expression.	Quercetin	17-26	catalase	Mus musculus	359-362
10590836-9	1999	Thus, quercetin appears to be an effective and selective inhibitor of HSF stress-induced activation and its ability to prevent the stress potentiation of GR suggests either a direct or indirect involvement by stress-activated HSF in this process, or the existence of a regulatory step common to both the heat shock and HSPE responses.	Quercetin	6-15	interleukin 6	Homo sapiens	70-73
10590836-9	1999	Thus, quercetin appears to be an effective and selective inhibitor of HSF stress-induced activation and its ability to prevent the stress potentiation of GR suggests either a direct or indirect involvement by stress-activated HSF in this process, or the existence of a regulatory step common to both the heat shock and HSPE responses.	Quercetin	6-15	nuclear receptor subfamily 3, group C, member 1	Mus musculus	154-156
10590836-9	1999	Thus, quercetin appears to be an effective and selective inhibitor of HSF stress-induced activation and its ability to prevent the stress potentiation of GR suggests either a direct or indirect involvement by stress-activated HSF in this process, or the existence of a regulatory step common to both the heat shock and HSPE responses.	Quercetin	6-15	interleukin 6	Homo sapiens	226-229
10961741-7	1999	The incubation with Rp-cAMPS (10 and 100 microM) 30 min prior to KCl shifted the dose-response curve of the flavonoids to the right, increasing their IC50 up to 27.8 +/- 3.8 and 31.9 +/- 7.3 microM, respectively, for genistein; 24.7 +/- 0.2 and 19.6 +/- 4.9 microM, respectively, for kaempferol; 18.8 +/- 2.2 and 18.4 +/- 1.5 microM, respectively, for quercetin.	Quercetin	352-361	calmodulin 2, pseudogene 1	Rattus norvegicus	23-28
10714603-0	2000	Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells.	Quercetin	71-80	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	13-40
10714603-2	2000	In the present study we examined the inducing effect of three of these compounds, chrysin, quercetin and genistein, on UDP-glucuronosyltransferase (UGT) in the human intestinal cell line Caco-2.	Quercetin	91-100	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	119-146
10714603-2	2000	In the present study we examined the inducing effect of three of these compounds, chrysin, quercetin and genistein, on UDP-glucuronosyltransferase (UGT) in the human intestinal cell line Caco-2.	Quercetin	91-100	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	148-151
10622719-3	1999	In this study, we showed that quercetin, a naturally occurring flavonoid, in association with the agonistic anti-CD95 monoclonal antibody, increases DNA fragmentation and caspase-3 activity in HPB-ALL cells.	Quercetin	30-39	Fas cell surface death receptor	Homo sapiens	113-117
10622719-3	1999	In this study, we showed that quercetin, a naturally occurring flavonoid, in association with the agonistic anti-CD95 monoclonal antibody, increases DNA fragmentation and caspase-3 activity in HPB-ALL cells.	Quercetin	30-39	caspase 3	Homo sapiens	171-180
10622719-5	1999	At molecular level, quercetin lowers the level of intracellular reactive oxygen species, reduces mitochondrial transmembrane potential, thereby leaving the expression of CD95 receptor unchanged.	Quercetin	20-29	Fas cell surface death receptor	Homo sapiens	170-174
10647909-6	1999	In RBC chrysin, quercetin and genistein significantly decreased the activity of glutathione reductase (GR), catalase (CAT) and glutathione peroxidase (GPx), whereas superoxide dismutase (SOD) was only significantly decreased by genistein.	Quercetin	16-25	glutathione-disulfide reductase	Rattus norvegicus	80-101
10647909-6	1999	In RBC chrysin, quercetin and genistein significantly decreased the activity of glutathione reductase (GR), catalase (CAT) and glutathione peroxidase (GPx), whereas superoxide dismutase (SOD) was only significantly decreased by genistein.	Quercetin	16-25	glutathione-disulfide reductase	Rattus norvegicus	103-105
10647909-6	1999	In RBC chrysin, quercetin and genistein significantly decreased the activity of glutathione reductase (GR), catalase (CAT) and glutathione peroxidase (GPx), whereas superoxide dismutase (SOD) was only significantly decreased by genistein.	Quercetin	16-25	catalase	Rattus norvegicus	108-116
10647909-6	1999	In RBC chrysin, quercetin and genistein significantly decreased the activity of glutathione reductase (GR), catalase (CAT) and glutathione peroxidase (GPx), whereas superoxide dismutase (SOD) was only significantly decreased by genistein.	Quercetin	16-25	catalase	Rattus norvegicus	118-121
10617062-3	1999	We observed that when endothelial cells pretreated with 5 or 50 microM of quercetin were incubated for 4 and 24 h with thrombin, ET-1 concentration-dependently decreased (n = 6, P &lt; 0.01, at 4 h IC50 = 1.54 microM, at 24 h IC50 = 2.78 microM).	Quercetin	74-83	coagulation factor II, thrombin	Homo sapiens	119-127
10558914-6	1999	We find that all of these eIF2alpha kinases can be activated by quercetin and genistein, indicating redundant roles of the eIF2alpha kinases.	Quercetin	64-73	eukaryotic translation initiation factor 2A	Homo sapiens	26-35
10558914-6	1999	We find that all of these eIF2alpha kinases can be activated by quercetin and genistein, indicating redundant roles of the eIF2alpha kinases.	Quercetin	64-73	eukaryotic translation initiation factor 2A	Homo sapiens	123-132
10617062-3	1999	We observed that when endothelial cells pretreated with 5 or 50 microM of quercetin were incubated for 4 and 24 h with thrombin, ET-1 concentration-dependently decreased (n = 6, P &lt; 0.01, at 4 h IC50 = 1.54 microM, at 24 h IC50 = 2.78 microM).	Quercetin	74-83	endothelin 1	Homo sapiens	129-133
10617062-4	1999	Under the same experimental conditions, quercetin significantly increased t-PA (n = 6, P &lt; 0.01, at 4 h EC50 = 0.71 microM and at 24 hrs EC50 = 0.74 microM).	Quercetin	40-49	chromosome 20 open reading frame 181	Homo sapiens	74-78
10617062-8	1999	Our data indicate that quercetin modulates the release of ET-1, t-PA, and PGI2 from vascular endothelial cells.	Quercetin	23-32	endothelin 1	Homo sapiens	58-62
10617062-8	1999	Our data indicate that quercetin modulates the release of ET-1, t-PA, and PGI2 from vascular endothelial cells.	Quercetin	23-32	chromosome 20 open reading frame 181	Homo sapiens	64-68
10556937-14	1999	The addition of EGF only marginally diminished the inhibitory effect of luteolin and quercetin on the growth rate of A431 cells, treatment of cellular proteins with EGF and luteolin or quercetin greatly reduced protein phosphorylation, indicating Lu and Qu may act effectively to inhibit a wide range of protein kinases, including EGFR tyrosine kinase.	Quercetin	85-94	epidermal growth factor	Homo sapiens	16-19
10551820-7	1999	Two natural compounds, quercetin and staurosporine, had previously been shown to inhibit the NF-kappaB pathway, but the molecular target(s) of these compounds in the event had not been established.	Quercetin	23-32	nuclear factor kappa B subunit 1	Homo sapiens	93-102
10551820-8	1999	Here we demonstrate that quercetin and staurosporine potently inhibit both IKKalpha and IKKbeta.	Quercetin	25-34	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	75-83
10551820-8	1999	Here we demonstrate that quercetin and staurosporine potently inhibit both IKKalpha and IKKbeta.	Quercetin	25-34	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	88-95
10551820-10	1999	This suggests that the inhibitory properties of quercetin and staurosporine in the NF-kappaB pathway are mediated in part by their inhibition of IKKalpha and IKKbeta.	Quercetin	48-57	nuclear factor kappa B subunit 1	Homo sapiens	83-92
10551820-10	1999	This suggests that the inhibitory properties of quercetin and staurosporine in the NF-kappaB pathway are mediated in part by their inhibition of IKKalpha and IKKbeta.	Quercetin	48-57	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	145-153
10551820-10	1999	This suggests that the inhibitory properties of quercetin and staurosporine in the NF-kappaB pathway are mediated in part by their inhibition of IKKalpha and IKKbeta.	Quercetin	48-57	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	158-165
10611419-0	1999	Exposure of rat thymocytes to hydrogen peroxide increases annexin V binding to membranes: inhibitory actions of deferoxamine and quercetin.	Quercetin	129-138	annexin A5	Rattus norvegicus	58-67
10556937-14	1999	The addition of EGF only marginally diminished the inhibitory effect of luteolin and quercetin on the growth rate of A431 cells, treatment of cellular proteins with EGF and luteolin or quercetin greatly reduced protein phosphorylation, indicating Lu and Qu may act effectively to inhibit a wide range of protein kinases, including EGFR tyrosine kinase.	Quercetin	85-94	epidermal growth factor	Homo sapiens	165-168
10556937-14	1999	The addition of EGF only marginally diminished the inhibitory effect of luteolin and quercetin on the growth rate of A431 cells, treatment of cellular proteins with EGF and luteolin or quercetin greatly reduced protein phosphorylation, indicating Lu and Qu may act effectively to inhibit a wide range of protein kinases, including EGFR tyrosine kinase.	Quercetin	185-194	epidermal growth factor	Homo sapiens	16-19
10556937-14	1999	The addition of EGF only marginally diminished the inhibitory effect of luteolin and quercetin on the growth rate of A431 cells, treatment of cellular proteins with EGF and luteolin or quercetin greatly reduced protein phosphorylation, indicating Lu and Qu may act effectively to inhibit a wide range of protein kinases, including EGFR tyrosine kinase.	Quercetin	185-194	epidermal growth factor receptor	Homo sapiens	331-335
10534310-4	1999	Quercetin efficiently inhibited quinone-type metabolite formation (at 10 microM troglitazone) in human samples that contained relatively high levels of CYP2C, whereas ketoconazole affected these activities in liver microsomes in which CYP3A4 levels were relatively high.	Quercetin	0-9	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	152-157
10534310-4	1999	Quercetin efficiently inhibited quinone-type metabolite formation (at 10 microM troglitazone) in human samples that contained relatively high levels of CYP2C, whereas ketoconazole affected these activities in liver microsomes in which CYP3A4 levels were relatively high.	Quercetin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	235-241
10454017-3	1999	In this report we provide evidence that the overproduction of TNF-alpha and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium.	Quercetin	138-147	tumor necrosis factor	Mus musculus	62-71
10541287-0	1999	Bioflavonoid quercetin inhibits interleukin-1-induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB.	Quercetin	13-22	chemokine (C-C motif) ligand 2	Mus musculus	84-118
10541287-2	1999	This report describes a novel potential of bioflavonoid quercetin as an inhibitor of monocyte chemoattractant protein-1 (MCP-1) in glomerular cells.	Quercetin	56-65	chemokine (C-C motif) ligand 2	Mus musculus	85-119
10541287-2	1999	This report describes a novel potential of bioflavonoid quercetin as an inhibitor of monocyte chemoattractant protein-1 (MCP-1) in glomerular cells.	Quercetin	56-65	chemokine (C-C motif) ligand 2	Mus musculus	121-126
10541287-4	1999	Quercetin dramatically inhibited the cytokine-triggered MCP-1 expression.	Quercetin	0-9	chemokine (C-C motif) ligand 2	Mus musculus	56-61
10541287-5	1999	To explore the mechanisms involved, effects of quercetin on the putative transcriptional activators of MCP-1, nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), were examined.	Quercetin	47-56	chemokine (C-C motif) ligand 2	Mus musculus	103-131
10541287-10	1999	These results suggest that: (1) quercetin has the ability to attenuate activation of NF-kappaB; and (2) it inhibits IL-1-triggered MCP-1 expression via suppression of NF-kappaB, but not AP-1, in glomerular cells.	Quercetin	32-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
10541287-10	1999	These results suggest that: (1) quercetin has the ability to attenuate activation of NF-kappaB; and (2) it inhibits IL-1-triggered MCP-1 expression via suppression of NF-kappaB, but not AP-1, in glomerular cells.	Quercetin	32-41	chemokine (C-C motif) ligand 2	Mus musculus	131-136
10541287-10	1999	These results suggest that: (1) quercetin has the ability to attenuate activation of NF-kappaB; and (2) it inhibits IL-1-triggered MCP-1 expression via suppression of NF-kappaB, but not AP-1, in glomerular cells.	Quercetin	32-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	167-176
10527657-1	1999	The level of nitrite accumulation in the culture media of astrocytes activated with lipopolysaccharide (LPS) and interferon-gamma (IFN) was decreased by pretreatment of cells with LY294002, a quercetin derivative developed for phosphatidylinositol-3-kinase (PI3K) inhibitor, in a dose-dependent manner.	Quercetin	192-201	interferon gamma	Mus musculus	113-135
10527657-1	1999	The level of nitrite accumulation in the culture media of astrocytes activated with lipopolysaccharide (LPS) and interferon-gamma (IFN) was decreased by pretreatment of cells with LY294002, a quercetin derivative developed for phosphatidylinositol-3-kinase (PI3K) inhibitor, in a dose-dependent manner.	Quercetin	192-201	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	227-256
10484327-0	1999	Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway.	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	29-35
10484327-0	1999	Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway.	Quercetin	0-9	mitogen-activated protein kinase 8	Homo sapiens	86-89
10484327-3	1999	The effect of quercetin on ICAM-1 expression induced by agonists phorbol 12-myristate 13-acetate (PMA) and tumor necrosis factor-alpha (TNF-alpha) in human endothelial cell line ECV304 (ECV) was investigated.	Quercetin	14-23	intercellular adhesion molecule 1	Homo sapiens	27-33
10484327-3	1999	The effect of quercetin on ICAM-1 expression induced by agonists phorbol 12-myristate 13-acetate (PMA) and tumor necrosis factor-alpha (TNF-alpha) in human endothelial cell line ECV304 (ECV) was investigated.	Quercetin	14-23	tumor necrosis factor	Homo sapiens	107-134
10484327-3	1999	The effect of quercetin on ICAM-1 expression induced by agonists phorbol 12-myristate 13-acetate (PMA) and tumor necrosis factor-alpha (TNF-alpha) in human endothelial cell line ECV304 (ECV) was investigated.	Quercetin	14-23	tumor necrosis factor	Homo sapiens	136-145
10484327-4	1999	Quercetin treatment downregulated both PMA- and TNF-alpha-induced surface expression, as well as the ICAM-1 mRNA levels, in ECV cells in a dose-dependent (10-50 microM) manner.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	48-57
10484327-4	1999	Quercetin treatment downregulated both PMA- and TNF-alpha-induced surface expression, as well as the ICAM-1 mRNA levels, in ECV cells in a dose-dependent (10-50 microM) manner.	Quercetin	0-9	intercellular adhesion molecule 1	Homo sapiens	101-107
10484327-7	1999	This decrease in AP-1 activation was observed to be associated with the inhibitory effects of quercetin on the c-Jun NH2-terminal kinase (JNK) pathway.	Quercetin	94-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-21
10484327-7	1999	This decrease in AP-1 activation was observed to be associated with the inhibitory effects of quercetin on the c-Jun NH2-terminal kinase (JNK) pathway.	Quercetin	94-103	mitogen-activated protein kinase 8	Homo sapiens	111-136
10484327-7	1999	This decrease in AP-1 activation was observed to be associated with the inhibitory effects of quercetin on the c-Jun NH2-terminal kinase (JNK) pathway.	Quercetin	94-103	mitogen-activated protein kinase 8	Homo sapiens	138-141
10484327-8	1999	These results suggest that quercetin downregulates both PMA- and TNF-alpha-induced ICAM-1 expression via inhibiting both AP-1 activation and the JNK pathway.	Quercetin	27-36	tumor necrosis factor	Homo sapiens	65-74
10484327-8	1999	These results suggest that quercetin downregulates both PMA- and TNF-alpha-induced ICAM-1 expression via inhibiting both AP-1 activation and the JNK pathway.	Quercetin	27-36	intercellular adhesion molecule 1	Homo sapiens	83-89
10484327-8	1999	These results suggest that quercetin downregulates both PMA- and TNF-alpha-induced ICAM-1 expression via inhibiting both AP-1 activation and the JNK pathway.	Quercetin	27-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-125
10484327-8	1999	These results suggest that quercetin downregulates both PMA- and TNF-alpha-induced ICAM-1 expression via inhibiting both AP-1 activation and the JNK pathway.	Quercetin	27-36	mitogen-activated protein kinase 8	Homo sapiens	145-148
10425183-0	1999	Inhibition of Vpr-induced cell cycle abnormality by quercetin: a novel strategy for searching compounds targeting Vpr.	Quercetin	52-61	Vpr	Human immunodeficiency virus 1	14-17
10425183-0	1999	Inhibition of Vpr-induced cell cycle abnormality by quercetin: a novel strategy for searching compounds targeting Vpr.	Quercetin	52-61	Vpr	Human immunodeficiency virus 1	114-117
10425183-5	1999	Quercetin (QCT), a compound of this crude drug, efficiently inhibited Vpr function without affecting its expression.	Quercetin	0-9	Vpr	Human immunodeficiency virus 1	70-73
10443459-5	1999	Quercetin was found to be the most effective compound on CK-II activity since its ID50 was approx.	Quercetin	0-9	casein kinase IIalpha	Drosophila melanogaster	57-62
11270969-4	1999	Norepinephrine-induced increase of [Ca2+]i was inhibited by the tyrosine kinase inhibitors quercetin and tyrphostin by 23.8% and 21.4%, respectively, but the accumulation of [3H]InsPs induced by norepinephrine was not.	Quercetin	91-100	TXK tyrosine kinase	Homo sapiens	64-79
10359656-0	1999	Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially.	Quercetin	18-27	aryl hydrocarbon receptor	Homo sapiens	62-87
10359656-13	1999	These results demonstrate that the dietary flavonols quercetin and kaempferol are natural, dietary ligands of the AhR that exert different effects on CYP1A1 transcription.	Quercetin	53-62	aryl hydrocarbon receptor	Homo sapiens	114-117
10359656-0	1999	Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially.	Quercetin	18-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-106
10359656-13	1999	These results demonstrate that the dietary flavonols quercetin and kaempferol are natural, dietary ligands of the AhR that exert different effects on CYP1A1 transcription.	Quercetin	53-62	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	150-156
10359656-2	1999	In the present study we have examined the effect of the common dietary polyphenolic compounds quercetin and kaempferol on the transcription of CYP1A1 and the function of the AhR in MCF-7 human breast cancer cells.	Quercetin	94-103	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	143-149
10359656-2	1999	In the present study we have examined the effect of the common dietary polyphenolic compounds quercetin and kaempferol on the transcription of CYP1A1 and the function of the AhR in MCF-7 human breast cancer cells.	Quercetin	94-103	aryl hydrocarbon receptor	Homo sapiens	174-177
10359656-3	1999	Quercetin caused a time- and concentration-dependent increase in the amount of CYP1A1 mRNA and CYP1A1 enzyme activity in MCF-7 cells.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-85
10359656-3	1999	Quercetin caused a time- and concentration-dependent increase in the amount of CYP1A1 mRNA and CYP1A1 enzyme activity in MCF-7 cells.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-101
10359656-4	1999	The increase in CYP1A1 mRNA caused by quercetin was prevented by the transcription inhibitor actinomycin D.	Quercetin	38-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-22
10359656-5	1999	Quercetin also caused an increase in the transcription of a chloramphenicol reporter vector containing the CYP1A1 promoter.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	107-113
10359656-7	1999	Gel retardation studies demonstrated that quercetin activated the ability of the AhR to bind to an oligonucleotide containing the xenobiotic-responsive element (XRE) of the CYP1A1 promoter.	Quercetin	42-51	aryl hydrocarbon receptor	Homo sapiens	81-84
10359656-7	1999	Gel retardation studies demonstrated that quercetin activated the ability of the AhR to bind to an oligonucleotide containing the xenobiotic-responsive element (XRE) of the CYP1A1 promoter.	Quercetin	42-51	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	173-179
10359656-8	1999	These results indicate that quercetin"s effect is mediated by the AhR.	Quercetin	28-37	aryl hydrocarbon receptor	Homo sapiens	66-69
10384728-8	1999	Most notable was a reduction of the cyanidin and quercetin content of tt15 seeds.	Quercetin	49-58	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	70-74
10354396-1	1999	Starting from the inhibitory activity of the flavonoid Quercetin, a series of 4H-1-benzopyran-4-one derivatives was synthesized and tested for inhibition of aldose reductase, an enzyme involved in the appearance of diabetic complications.	Quercetin	55-64	aldo-keto reductase family 1 member B	Homo sapiens	157-173
10354396-2	1999	Some of the compounds obtained display inhibitory activity similar to that of Sorbinil but are more selective than Quercetin and Sorbinil with respect to the closely related enzyme, aldehyde reductase, and also possess antioxidant activity.	Quercetin	115-124	aldo-keto reductase family 1 member A1	Homo sapiens	182-200
10403140-5	1999	The activity-guided fractionation of the extract, based on the determination of inhibitory effect upon the release of beta-hexosaminidase, led to the isolation of quercetin as an active principle responsible for the inhibition of degranulation.	Quercetin	163-172	O-GlcNAcase	Rattus norvegicus	118-137
10405873-3	1999	The flavonoid quercetin is one of very few molecules that inhibit RBL cell proliferation and constitutive histamine release; it also induces synthesis of rat mast cell protease (RMCP) II and accumulation of secretory granules.	Quercetin	14-23	mast cell protease 2	Rattus norvegicus	178-186
10678090-10	1999	Besides, [Ca2+]i rises excited by angiotensin II (Ang II) but not high [K+]o were prevented by Que 100 mumol.L-1.	Quercetin	95-98	angiotensinogen	Rattus norvegicus	34-48
10678090-10	1999	Besides, [Ca2+]i rises excited by angiotensin II (Ang II) but not high [K+]o were prevented by Que 100 mumol.L-1.	Quercetin	95-98	angiotensinogen	Rattus norvegicus	50-56
10086329-6	1999	Northern blot analysis indicated that quercetin (0.1 and 0.2 mM) inhibited LPS-dependent production of inducible nitric oxide synthase (iNOS) mRNA and decreased NO release, as measured by the Griess reaction.	Quercetin	38-47	nitric oxide synthase 2	Homo sapiens	103-134
10086329-6	1999	Northern blot analysis indicated that quercetin (0.1 and 0.2 mM) inhibited LPS-dependent production of inducible nitric oxide synthase (iNOS) mRNA and decreased NO release, as measured by the Griess reaction.	Quercetin	38-47	nitric oxide synthase 2	Homo sapiens	136-140
10331966-1	1999	Quercetin is a flavonoid well known to inhibit growth and heat shock protein (HSP) synthesis of cancer cells.	Quercetin	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	58-76
10232833-11	1999	Antioxidants such as the flavonoids glabridin or quercetin, when present during LDL oxidation in the presence of PON, reduced the amount of lipoprotein-associated lipid peroxides and preserved PON activities, including its ability to hydrolyze Ox-LDL cholesteryl linoleate hydroperoxides.	Quercetin	49-58	paraoxonase 1	Homo sapiens	113-116
10232833-11	1999	Antioxidants such as the flavonoids glabridin or quercetin, when present during LDL oxidation in the presence of PON, reduced the amount of lipoprotein-associated lipid peroxides and preserved PON activities, including its ability to hydrolyze Ox-LDL cholesteryl linoleate hydroperoxides.	Quercetin	49-58	paraoxonase 1	Homo sapiens	193-196
10331966-1	1999	Quercetin is a flavonoid well known to inhibit growth and heat shock protein (HSP) synthesis of cancer cells.	Quercetin	0-9	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	78-81
10331966-6	1999	This inhibitory effect of quercetin on tolerance to heat shock is thought to be due to marked suppression of HSP72.	Quercetin	26-35	heat shock protein family A (Hsp70) member 1A	Homo sapiens	109-114
10331966-9	1999	Since HSP90 could preserve F-actin structure during stresses, quercetin might affect the interaction between HSP90 and F-actin without influencing HSP90 expression.	Quercetin	62-71	heat shock protein 90 alpha family class A member 1	Homo sapiens	109-114
10331966-9	1999	Since HSP90 could preserve F-actin structure during stresses, quercetin might affect the interaction between HSP90 and F-actin without influencing HSP90 expression.	Quercetin	62-71	heat shock protein 90 alpha family class A member 1	Homo sapiens	109-114
10090785-1	1999	Using a pharmacophore model for ATP-competitive inhibitors interacting with the active site of the EGFR protein tyrosine kinase together with published X-ray crystal data of quercetin (2) in complex with the Hck tyrosine kinase and of deschloroflavopiridol (3b) in complex with CDK2, a putative binding mode of the isoflavone genistein (1) was proposed.	Quercetin	174-183	epidermal growth factor receptor	Homo sapiens	99-103
10082992-0	1999	Quercetin inhibited DNA synthesis and induced apoptosis associated with increase in c-fos mRNA level and the upregulation of p21WAF1CIP1 mRNA and protein expression during liver regeneration after partial hepatectomy.	Quercetin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-89
10082992-4	1999	Northern blot analysis revealed that quercetin induced the increases in c-fos and p21WAF1CIP1 mRNA levels within 2 h. The expression of p21 protein was also enhanced, while p53 mRNA and protein levels were not affected by quercetin.	Quercetin	37-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-77
10082992-4	1999	Northern blot analysis revealed that quercetin induced the increases in c-fos and p21WAF1CIP1 mRNA levels within 2 h. The expression of p21 protein was also enhanced, while p53 mRNA and protein levels were not affected by quercetin.	Quercetin	37-46	cyclin dependent kinase inhibitor 1A	Homo sapiens	82-85
10082992-4	1999	Northern blot analysis revealed that quercetin induced the increases in c-fos and p21WAF1CIP1 mRNA levels within 2 h. The expression of p21 protein was also enhanced, while p53 mRNA and protein levels were not affected by quercetin.	Quercetin	37-46	tumor protein p53	Homo sapiens	173-176
10082992-5	1999	These results suggest that quercetin-induced apoptosis is associated with the increase in c-fos mRNA level and the upregulation of p21 mRNA and protein expression, probably in a p53-independent pathway.	Quercetin	27-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-95
10082992-5	1999	These results suggest that quercetin-induced apoptosis is associated with the increase in c-fos mRNA level and the upregulation of p21 mRNA and protein expression, probably in a p53-independent pathway.	Quercetin	27-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	131-134
10082992-5	1999	These results suggest that quercetin-induced apoptosis is associated with the increase in c-fos mRNA level and the upregulation of p21 mRNA and protein expression, probably in a p53-independent pathway.	Quercetin	27-36	tumor protein p53	Homo sapiens	178-181
10408175-3	1999	Quercetin, an inhibitor of heat-shock response, dose dependently suppressed the p53 accumulation induced by X-rays at more than 100 microM.	Quercetin	0-9	tumor protein p53	Homo sapiens	80-83
10344638-7	1999	A separate reaction results in a polymeric quercetin product which is highly retained on a reversed-phase C18 HPLC column.	Quercetin	43-52	Bardet-Biedl syndrome 9	Homo sapiens	106-109
9890986-11	1999	In addition, we found that, among the inhibitors of tyrosine kinases, cyclooxygenase, and Ca2+ influx, only quercetin exerted a significant inhibitory effect on HNE-induced JNK activation.	Quercetin	108-117	mitogen-activated protein kinase 8	Rattus norvegicus	173-176
10693172-0	1999	Quercetin inhibits benzo[a]pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 1A1 gene expression.	Quercetin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-108
10470366-10	1999	Quercetin and genistein chiefly inhibited PI-4 kinase and PIP kinase, respectively, and as a result reduced IP3 concentration in cancer cells.	Quercetin	0-9	prolactin induced protein	Homo sapiens	58-61
10453447-0	1999	Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling.	Quercetin	0-9	epidermal growth factor	Homo sapiens	72-75
10453447-7	1999	On the cellular level, quercetin sensitivity was correlated with epidermal growth factor (EGF) receptor levels, rapid growth, and poor differentiation, indicating the possibility of targeting those cells most harmful for the organism.	Quercetin	23-32	epidermal growth factor receptor	Homo sapiens	65-103
10453447-10	1999	In summary, the data indicate that inhibition of EGF receptor kinase is an integral part of quercetin-induced growth inhibition, but additional mechanisms also contribute to the overall effect.	Quercetin	92-101	epidermal growth factor	Homo sapiens	49-52
10709674-21	1999	The use of the AOM-induced ACF assay to screen agents for the ability to prevent colon tumors would appear to result in false positive responses including agents (2-CPR and quercetin) that actually promote colon cancer.	Quercetin	173-182	ACF	Homo sapiens	27-30
10608619-3	1999	Quercetin, a plant flavonoid, exhibits antineoplastic activity and inhibits PI 4-kinase (EC 2.7.1.67) and PIP 5-kinase (EC 2.7.1.68) activity.	Quercetin	0-9	serpin family A member 4	Homo sapiens	76-80
10693172-8	1999	From the assays of both enzyme activities, quercetin inhibits CYP1A1-linked ethoxyresorufin O-dealkylase activity more effectively than glutathione S-transferase activity.	Quercetin	43-52	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	62-68
10693172-9	1999	To elucidate the molecular mechanisms, reverse transcriptase-polymerase chain reaction and Western blot were used to evaluate whether the decrease in CYP1A1 enzyme activity by quercetin is mediated because of alterations of CYP1A1 transcription or mRNA stability.	Quercetin	176-185	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	150-156
10693172-9	1999	To elucidate the molecular mechanisms, reverse transcriptase-polymerase chain reaction and Western blot were used to evaluate whether the decrease in CYP1A1 enzyme activity by quercetin is mediated because of alterations of CYP1A1 transcription or mRNA stability.	Quercetin	176-185	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	224-230
10693172-10	1999	The results indicated that quercetin significantly inhibits B[a]P-induced CYP1A1 mRNA and protein expression.	Quercetin	27-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	74-80
10693172-11	1999	From these findings, we conclude that quercetin suppresses B[a]P-induced DNA damage in human Hep G2 cells by altering CYP1A1 gene expression.	Quercetin	38-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-124
9815107-1	1998	The ability of the flavonoids genistein, apigenin, kaempferol, and quercetin to activate cystic fibrosis transmembrane conductance regulator-mediated Cl currents in human airway epithelium was investigated.	Quercetin	67-76	CF transmembrane conductance regulator	Homo sapiens	89-140
9771928-3	1998	A similar inhibition by quercetin of H2O2-induced NF-kappaB transcriptional activation was demonstrated using a cat reporter gene assay.	Quercetin	24-33	nuclear factor kappa B subunit 1	Homo sapiens	50-59
9925038-0	1998	Inhibition of oxidant-induced lipid peroxidation in cultured renal tubular epithelial cells (LLC-PK1) by quercetin.	Quercetin	105-114	prokineticin 1	Homo sapiens	97-100
10437144-0	1998	Quercetin down-regulated bcl-2 gene expression in human leukemia HL-60 cells.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	25-30
10437144-1	1998	AIM: To study the effect of quercetin (Que) on bcl-2 gene expression in human leukemia HL-60 cells.	Quercetin	28-37	BCL2 apoptosis regulator	Homo sapiens	47-52
10437144-1	1998	AIM: To study the effect of quercetin (Que) on bcl-2 gene expression in human leukemia HL-60 cells.	Quercetin	39-42	BCL2 apoptosis regulator	Homo sapiens	47-52
9771928-0	1998	Quercetin inhibits hydrogen peroxide (H2O2)-induced NF-kappaB DNA binding activity and DNA damage in HepG2 cells.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	52-61
9744814-5	1998	Similarly, the Hsp27 dephosphorylation/insolubilization/granulation and the cytoskeletal and morphological disturbances resulting from lack of ATP were suppressed in heat-preconditioned (thermotolerant) cultures, this effect being sensitive to quercetin, a blocker of Hsp induction.	Quercetin	244-253	heat shock protein family B (small) member 1	Homo sapiens	15-20
9744814-5	1998	Similarly, the Hsp27 dephosphorylation/insolubilization/granulation and the cytoskeletal and morphological disturbances resulting from lack of ATP were suppressed in heat-preconditioned (thermotolerant) cultures, this effect being sensitive to quercetin, a blocker of Hsp induction.	Quercetin	244-253	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	15-18
9873828-2	1998	Therefore, it was examined whether quercetin, which has been shown to interfere with the formation of the complex between HSE and HSF, and to downregulate the level of HSF1, can sensitize MDR cells against anticancer drugs by inhibition of HSF DNA-binding activity.	Quercetin	35-44	heat shock factor 1	Mus musculus	168-172
9873828-5	1998	These results were well consistent with the finding that the treatment of quercetin decreased the expression level of P-gp, MDR1 gene product, in dose-dependent manner, and markedly increased the sensitivity of MDR cells to vincristine or vinblastine.	Quercetin	74-83	phosphoglycolate phosphatase	Mus musculus	118-122
9873828-5	1998	These results were well consistent with the finding that the treatment of quercetin decreased the expression level of P-gp, MDR1 gene product, in dose-dependent manner, and markedly increased the sensitivity of MDR cells to vincristine or vinblastine.	Quercetin	74-83	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	124-128
9873828-6	1998	These results suggest that quercetin can decrease the expression of P-gp via inhibition of HSF DNA-binding activity, and might be useful as a chemosensitizer in MDR cells.	Quercetin	27-36	phosphoglycolate phosphatase	Mus musculus	68-72
9675312-5	1998	Lipoxygenase inhibitors quercetin and nordihydroguiaretic acid inhibited GST-P-positive nodules but not cirrhosis or 8-OHdG.	Quercetin	24-33	glutathione S-transferase pi 1	Rattus norvegicus	73-78
9654140-4	1998	These phosphorylations are selectively inhibited by CK-II inhibitors, such as quercetin, oGA (a glycyrrhetinic acid derivative) and NCS-chrom (an enediyne containing antibiotic).	Quercetin	78-87	casein kinase 2 alpha 1	Homo sapiens	52-57
9622659-6	1998	The DMSO-induced increase in MT mRNA expression was reversed by treatment of astrocytes with quercetin, such that MT-I and MT-II mRNA levels in DMSO plus quercetin-treated astrocytes were indistinguishable from mRNA levels in their respective controls at pH 7.4, pH 6.5, and pH 6.0.	Quercetin	93-102	metallothionein 1	Rattus norvegicus	114-118
9622659-6	1998	The DMSO-induced increase in MT mRNA expression was reversed by treatment of astrocytes with quercetin, such that MT-I and MT-II mRNA levels in DMSO plus quercetin-treated astrocytes were indistinguishable from mRNA levels in their respective controls at pH 7.4, pH 6.5, and pH 6.0.	Quercetin	154-163	metallothionein 1	Rattus norvegicus	114-118
9616184-7	1998	In addition to amines, expressed human UGT1A3 catalyzed the glucuronidation of opioids (e.g. morphine and buprenorphine), coumarins, flavonoids (e.g. naringenin and quercetin), anthraquinones, and small phenolic compounds (e.g. 4-nitrophenol).	Quercetin	165-174	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	39-45
9634009-5	1998	The apical to basolateral flux of quercetin, Papp 5.8 +/- 1.1 x 10(-6) cm x sec(-1) (mean +/- SEM), was more than 10-fold higher than for the paracellular transport marker mannitol, 0.48 +/- 0.09 x 10(-6) cm x sec(-1) (P &lt; 0.01).	Quercetin	34-43	secretory blood group 1, pseudogene	Homo sapiens	76-82
9590266-0	1998	Quercetin sensitizes RBL-2H3 cells to polybasic mast cell secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway.	Quercetin	0-9	RB transcriptional corepressor like 2	Rattus norvegicus	21-26
9634009-5	1998	The apical to basolateral flux of quercetin, Papp 5.8 +/- 1.1 x 10(-6) cm x sec(-1) (mean +/- SEM), was more than 10-fold higher than for the paracellular transport marker mannitol, 0.48 +/- 0.09 x 10(-6) cm x sec(-1) (P &lt; 0.01).	Quercetin	34-43	secretory blood group 1, pseudogene	Homo sapiens	76-83
9634009-7	1998	Interestingly, the reverse, basolateral to apical, flux of quercetin (Papp 11.1 +/- 1.2 x 10(-6) cm x sec(-1)) was almost 2-fold higher than the apical to basolateral flux (P &lt; 0.001).	Quercetin	59-68	secretory blood group 1, pseudogene	Homo sapiens	102-108
9521814-4	1998	Suppression correlated with PTK activity, since among the structural analogues of genistein, only an active inhibitor of PTK, quercetin blocked TNF-induced NF-kappaB activation and not daidzein, an inactive inhibitor.	Quercetin	126-135	protein tyrosine kinase 2 beta	Homo sapiens	28-31
9593940-5	1998	Quercetin, an inhibitor of HSP expression, decreased the expression of HSP72 and inhibited the recovery of cAMP levels 24 h after heat shock.	Quercetin	0-9	heat shock protein 1A	Mus musculus	71-76
9593940-6	1998	Quercetin also decreased the basal expression of the constitutive heat shock cognate protein 70 (HSC70) and suppressed cAMP accumulation in non-heat shocked cells.	Quercetin	0-9	heat shock protein 8	Mus musculus	66-95
9593940-6	1998	Quercetin also decreased the basal expression of the constitutive heat shock cognate protein 70 (HSC70) and suppressed cAMP accumulation in non-heat shocked cells.	Quercetin	0-9	heat shock protein 8	Mus musculus	97-102
9581680-3	1998	Expression of smooth muscle alpha-actin was suppressed by a high dose of resveratrol and quercetin.	Quercetin	89-98	actin alpha 2, smooth muscle	Rattus norvegicus	14-39
9581680-7	1998	On the other hand, kinetic analysis showed that production of nitric oxide (NO) and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide-stimulated Kupffer cells was strongly inhibited by resveratrol and quercetin but not by NAC.	Quercetin	213-222	tumor necrosis factor	Rattus norvegicus	84-111
9581680-7	1998	On the other hand, kinetic analysis showed that production of nitric oxide (NO) and tumor necrosis factor alpha (TNF-alpha) by lipopolysaccharide-stimulated Kupffer cells was strongly inhibited by resveratrol and quercetin but not by NAC.	Quercetin	213-222	tumor necrosis factor	Rattus norvegicus	113-122
11601313-1	1998	The quercetin in Changyannning Tablets was determined by reverse phase HPLC on Shim-Pack CLC-ODS column(150 mm x 4.6 mm) with UV detector and methanol-water-phosphoric acid(55:44.6:0.4) as mobile phase (1.0 ml/min).	Quercetin	4-13	Charcot-Leyden crystal galectin	Homo sapiens	89-92
9521814-4	1998	Suppression correlated with PTK activity, since among the structural analogues of genistein, only an active inhibitor of PTK, quercetin blocked TNF-induced NF-kappaB activation and not daidzein, an inactive inhibitor.	Quercetin	126-135	protein tyrosine kinase 2 beta	Homo sapiens	121-124
9521814-4	1998	Suppression correlated with PTK activity, since among the structural analogues of genistein, only an active inhibitor of PTK, quercetin blocked TNF-induced NF-kappaB activation and not daidzein, an inactive inhibitor.	Quercetin	126-135	tumor necrosis factor	Homo sapiens	144-147
9521814-4	1998	Suppression correlated with PTK activity, since among the structural analogues of genistein, only an active inhibitor of PTK, quercetin blocked TNF-induced NF-kappaB activation and not daidzein, an inactive inhibitor.	Quercetin	126-135	nuclear factor kappa B subunit 1	Homo sapiens	156-165
9429083-6	1997	Quercetin inhibited activity of human cytochrome P-450 towards ethoxycoumarin and ethylresorufin at relatively low substrate concentrations (0.1 microM and above).	Quercetin	0-9	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-54
9482255-7	1998	Quercetin reduced the expression of HSC70 to an even greater extent than transfection, and prevented the induction of HSP70.	Quercetin	0-9	heat shock protein family A (Hsp70) member 8	Homo sapiens	36-41
9482255-7	1998	Quercetin reduced the expression of HSC70 to an even greater extent than transfection, and prevented the induction of HSP70.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	118-123
9482255-8	1998	In contrast to antisense-treated cells, MBP synthesis was essentially blocked in quercetin-treated cells even though levels of HSP25 and GRP78 increased.	Quercetin	81-90	myelin basic protein	Homo sapiens	40-43
9492341-4	1998	We found that naringenin, a flavanone, and quercetin and kaempferol, flavonols, inhibit estrogen binding to AFP with apparent Kds of about 5 x 10(-7) M. To our surprise, the two isoflavonoids, daidzein and genistein, have Kds of about 5 x 10(-6) M for AFP.	Quercetin	43-52	alpha-fetoprotein	Rattus norvegicus	108-111
9461039-7	1997	The data show that, of the flavonoids, the flavonols are the most effective inducers of quinone reductase activity in Hepa1c1c7 cells (kaempferol approximately galangin &gt; quercetin &gt; myricetin approximately apigenin (a flavone)) and that flavanols and flavans are ineffective.	Quercetin	174-183	crystallin, zeta	Mus musculus	88-105
9448720-0	1998	Inhibition of mammalian 15-lipoxygenase-dependent lipid peroxidation in low-density lipoprotein by quercetin and quercetin monoglucosides.	Quercetin	99-108	arachidonate 15-lipoxygenase	Homo sapiens	24-39
16793753-5	1998	The expression of CD62 was inhibited by the lipoxygenase (LOX) inhibitors quercetin and nordihydroguaiaretic acid but was not affected by the cyclooxygenase (COX) inhibitors aspirin and indomethacin.	Quercetin	74-83	selectin P	Homo sapiens	18-22
12168008-3	1998	Moreover, quercetin completely eliminated the stimulating effect of EGF or PMA on GnT-V.	Quercetin	10-19	epidermal growth factor	Homo sapiens	68-71
12168008-3	1998	Moreover, quercetin completely eliminated the stimulating effect of EGF or PMA on GnT-V.	Quercetin	10-19	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	82-87
9367858-2	1997	To determine whether quercetin could inhibit hsp expression in breast cancer cells, we used the human breast cancer cell line, MDA-MB-231.	Quercetin	21-30	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	45-48
9367858-3	1997	Treatment of these cells with quercetin decreased the heat-induced synthesis of hsp27 and hsp70.	Quercetin	30-39	heat shock protein family B (small) member 1	Homo sapiens	80-85
9367858-3	1997	Treatment of these cells with quercetin decreased the heat-induced synthesis of hsp27 and hsp70.	Quercetin	30-39	heat shock protein family A (Hsp70) member 4	Homo sapiens	90-95
9367858-5	1997	Furthermore, while quercetin treatment inhibited HSF2 expression, it only slightly affected HSF1 expression in breast cancer cells.	Quercetin	19-28	heat shock transcription factor 2	Homo sapiens	49-53
9367858-6	1997	In contrast, quercetin inhibited both HSF DNA-binding activity and HSF expression in HeLa cells.	Quercetin	13-22	interleukin 6	Homo sapiens	38-41
9367858-6	1997	In contrast, quercetin inhibited both HSF DNA-binding activity and HSF expression in HeLa cells.	Quercetin	13-22	interleukin 6	Homo sapiens	67-70
9367858-7	1997	Our studies suggest that quercetin"s action is cell-type specific, and in breast cancer cells may involve regulation of HSF transcriptional activity, rather than regulation of its DNA-binding activity.	Quercetin	25-34	interleukin 6	Homo sapiens	120-123
9334813-6	1997	To explain this difference in sensitivity of leukemic and normal hematopoietic progenitors, we analyzed the effect of quercetin on heat-induced expression of heat-shock protein-70 (HSP-70), which has been shown to be important in regulating thermosensitivity.	Quercetin	118-127	heat shock protein family A (Hsp70) member 4	Homo sapiens	158-179
9334813-6	1997	To explain this difference in sensitivity of leukemic and normal hematopoietic progenitors, we analyzed the effect of quercetin on heat-induced expression of heat-shock protein-70 (HSP-70), which has been shown to be important in regulating thermosensitivity.	Quercetin	118-127	heat shock protein family A (Hsp70) member 4	Homo sapiens	181-187
9334813-7	1997	We found that quercetin inhibits heat-induced HSP-70 expression both at protein and at mRNA levels in AML and ALL blasts.	Quercetin	14-23	heat shock protein family A (Hsp70) member 4	Homo sapiens	46-52
9449200-0	1997	Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids.	Quercetin	61-70	steroid sulfatase	Homo sapiens	14-31
9292787-6	1997	RESULTS: Addition of quercetin suppressed TNF-alpha induced increase in the mRNA for IL-8 and MCP-1 in a dose dependent manner.	Quercetin	21-30	tumor necrosis factor	Homo sapiens	42-51
9292787-6	1997	RESULTS: Addition of quercetin suppressed TNF-alpha induced increase in the mRNA for IL-8 and MCP-1 in a dose dependent manner.	Quercetin	21-30	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
9292787-6	1997	RESULTS: Addition of quercetin suppressed TNF-alpha induced increase in the mRNA for IL-8 and MCP-1 in a dose dependent manner.	Quercetin	21-30	C-C motif chemokine ligand 2	Homo sapiens	94-99
9292787-8	1997	H2O2 mediated induction of IL-8 and MCP-1 genes was also inhibited by quercetin.	Quercetin	70-79	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
9292787-8	1997	H2O2 mediated induction of IL-8 and MCP-1 genes was also inhibited by quercetin.	Quercetin	70-79	C-C motif chemokine ligand 2	Homo sapiens	36-41
9292787-9	1997	EMSA revealed that quercetin inhibited the activation of NF-kappa B by TNF-alpha.	Quercetin	19-28	nuclear factor kappa B subunit 1	Homo sapiens	57-67
9292787-9	1997	EMSA revealed that quercetin inhibited the activation of NF-kappa B by TNF-alpha.	Quercetin	19-28	tumor necrosis factor	Homo sapiens	71-80
9292787-10	1997	CONCLUSION: Quercetin suppresses TNF-alpha mediated stimulation of IL-8 and MCP-1 expression, at least in part, by inhibiting the activation of NF-kappa B.	Quercetin	12-21	tumor necrosis factor	Homo sapiens	33-42
9292787-0	1997	Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	53-66
9292787-0	1997	Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells.	Quercetin	0-9	C-C motif chemokine ligand 2	Homo sapiens	71-105
9292787-0	1997	Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	120-147
9292787-3	1997	Based on our recent finding that reactive oxygen intermediates play important roles in mediating TNF-alpha action, we examined the effect of an antioxidant bioflavonoid, quercetin, on TNF-alpha induced expression of interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in cultured human synovial cells.	Quercetin	170-179	tumor necrosis factor	Mus musculus	184-193
9292787-3	1997	Based on our recent finding that reactive oxygen intermediates play important roles in mediating TNF-alpha action, we examined the effect of an antioxidant bioflavonoid, quercetin, on TNF-alpha induced expression of interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in cultured human synovial cells.	Quercetin	170-179	chemokine (C-X-C motif) ligand 15	Mus musculus	216-229
9292787-3	1997	Based on our recent finding that reactive oxygen intermediates play important roles in mediating TNF-alpha action, we examined the effect of an antioxidant bioflavonoid, quercetin, on TNF-alpha induced expression of interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in cultured human synovial cells.	Quercetin	170-179	chemokine (C-X-C motif) ligand 15	Mus musculus	231-235
9292787-10	1997	CONCLUSION: Quercetin suppresses TNF-alpha mediated stimulation of IL-8 and MCP-1 expression, at least in part, by inhibiting the activation of NF-kappa B.	Quercetin	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
9292787-10	1997	CONCLUSION: Quercetin suppresses TNF-alpha mediated stimulation of IL-8 and MCP-1 expression, at least in part, by inhibiting the activation of NF-kappa B.	Quercetin	12-21	C-C motif chemokine ligand 2	Homo sapiens	76-81
9292787-10	1997	CONCLUSION: Quercetin suppresses TNF-alpha mediated stimulation of IL-8 and MCP-1 expression, at least in part, by inhibiting the activation of NF-kappa B.	Quercetin	12-21	nuclear factor kappa B subunit 1	Homo sapiens	144-154
9449200-4	1997	The natural flavonoids, quercetin, kaempferol, and naringenin, significantly inhibited estrone sulfatase activity with I50 &lt; 10 microM for the most potent, quercetin.	Quercetin	24-33	steroid sulfatase	Homo sapiens	87-104
9449200-4	1997	The natural flavonoids, quercetin, kaempferol, and naringenin, significantly inhibited estrone sulfatase activity with I50 &lt; 10 microM for the most potent, quercetin.	Quercetin	159-168	steroid sulfatase	Homo sapiens	87-104
9449200-7	1997	Quercetin, a natural dietary constituent, is a potent inhibitor of estrone sulfatase in vitro, and thus has the potential to express antiestrogenic activity in vivo.	Quercetin	0-9	steroid sulfatase	Homo sapiens	67-84
9379919-2	1997	The presence of an external metabolizing system, such as rat liver homogenates (S9 mix), leads to an increase in its genotoxicity, which is attributed to its biotransformation to the more genotoxic flavonoid quercetin, via the cytochrome P450 (CYP) mono-oxygenase system.	Quercetin	208-217	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	227-242
9379919-2	1997	The presence of an external metabolizing system, such as rat liver homogenates (S9 mix), leads to an increase in its genotoxicity, which is attributed to its biotransformation to the more genotoxic flavonoid quercetin, via the cytochrome P450 (CYP) mono-oxygenase system.	Quercetin	208-217	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	244-247
9379919-8	1997	The results obtained in this work suggest that rat CYP 1A1 is, among the cytochromes studied, the one that plays the major role in the transformation of kaempferol into quercetin.	Quercetin	169-178	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	51-58
9277581-6	1997	To explore the molecular mechanisms involved, we tested the effect of quercetin on c-Jun/activator protein-1 AP-1), the crucial mediator for H2O2-initiated apoptosis.	Quercetin	70-79	transcription factor Jun	Sus scrofa	83-88
9300039-11	1997	Moreover the enzyme was found to be highly resistant to heparin, a potent inhibitor of casein kinase II (CK II) and also resistant to CK I-7, a synthetic inhibitor of CK I, but very sensitive to a bioflavonoid quercetin.	Quercetin	210-219	casein kinase 2 alpha 1	Homo sapiens	87-103
9300039-11	1997	Moreover the enzyme was found to be highly resistant to heparin, a potent inhibitor of casein kinase II (CK II) and also resistant to CK I-7, a synthetic inhibitor of CK I, but very sensitive to a bioflavonoid quercetin.	Quercetin	210-219	casein kinase 2 alpha 1	Homo sapiens	105-110
9300039-11	1997	Moreover the enzyme was found to be highly resistant to heparin, a potent inhibitor of casein kinase II (CK II) and also resistant to CK I-7, a synthetic inhibitor of CK I, but very sensitive to a bioflavonoid quercetin.	Quercetin	210-219	choline kinase alpha	Homo sapiens	134-138
9277581-7	1997	Northern blot analysis revealed that quercetin suppressed the c-jun expression by H2O2.	Quercetin	37-46	transcription factor Jun	Sus scrofa	62-67
9277581-9	1997	These results suggested that quercetin inhibited apoptosis via intervention in the c-Jun/AP-1 pathway.	Quercetin	29-38	transcription factor Jun	Sus scrofa	83-88
9089688-5	1997	A participation of quercetin-inhibitable lactate transport in glial pHi-regulation is suggested by the observation that pHi-homeostasis after acidification by diffusion of undissociated lactic acid into the cell is inhibited by quercetin.	Quercetin	19-28	glucose-6-phosphate isomerase	Rattus norvegicus	68-71
9142921-9	1997	Quercetin blocked HSP70 induction and the protective effect of Gln and DON.	Quercetin	0-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	18-23
9089688-5	1997	A participation of quercetin-inhibitable lactate transport in glial pHi-regulation is suggested by the observation that pHi-homeostasis after acidification by diffusion of undissociated lactic acid into the cell is inhibited by quercetin.	Quercetin	19-28	glucose-6-phosphate isomerase	Rattus norvegicus	120-123
9089688-5	1997	A participation of quercetin-inhibitable lactate transport in glial pHi-regulation is suggested by the observation that pHi-homeostasis after acidification by diffusion of undissociated lactic acid into the cell is inhibited by quercetin.	Quercetin	228-237	glucose-6-phosphate isomerase	Rattus norvegicus	68-71
9089688-5	1997	A participation of quercetin-inhibitable lactate transport in glial pHi-regulation is suggested by the observation that pHi-homeostasis after acidification by diffusion of undissociated lactic acid into the cell is inhibited by quercetin.	Quercetin	228-237	glucose-6-phosphate isomerase	Rattus norvegicus	120-123
9054616-5	1997	The number of foci induced by methylcholanthrene, N-methyl-N"-nitro-N-nitrosoguanidine or quercetin was significantly reduced when the cultures were treated with TGF-beta.	Quercetin	90-99	transforming growth factor beta 1	Homo sapiens	162-170
9027743-6	1997	In vivo studies using quercetin to inhibit hsp70 induction support the notion that hsp70 is involved in ERBP-Epo RNA complex formation.	Quercetin	22-31	heat shock protein family A (Hsp70) member 4	Homo sapiens	43-48
9027743-6	1997	In vivo studies using quercetin to inhibit hsp70 induction support the notion that hsp70 is involved in ERBP-Epo RNA complex formation.	Quercetin	22-31	heat shock protein family A (Hsp70) member 4	Homo sapiens	83-88
9027743-6	1997	In vivo studies using quercetin to inhibit hsp70 induction support the notion that hsp70 is involved in ERBP-Epo RNA complex formation.	Quercetin	22-31	deoxynucleotidyltransferase terminal interacting protein 2	Homo sapiens	104-108
9027743-6	1997	In vivo studies using quercetin to inhibit hsp70 induction support the notion that hsp70 is involved in ERBP-Epo RNA complex formation.	Quercetin	22-31	erythropoietin	Homo sapiens	109-112
9290125-2	1997	The location of hydroxyl functional groups at 2", 3", or 4" site(s), especially at the 4" site, as in apigenin, fisetin, morin, myricetin, and quercetin, seems essential for anti-TPA-induced transformation, anti-protein kinase C (PKC) activation, and anti-TPA-induced c-jun expression activities.	Quercetin	143-152	jun proto-oncogene	Mus musculus	268-273
9112431-0	1997	Synergistic cytotoxic effect of quercetin and heat treatment in a lymphoid cell line (OZ) with low HSP70 expression.	Quercetin	32-41	heat shock protein family A (Hsp70) member 4	Homo sapiens	99-104
9381980-24	1997	Quercetin and genistein are able to inhibit PI and PIP kinase activities and reduce IP3 concentration in vivo and in tissue culture systems.	Quercetin	0-9	prolactin induced protein	Homo sapiens	51-54
14646550-6	1997	Inhibition of hsp70 accumulation by quercetin made cells more susceptible to the same apoptotic inducer.	Quercetin	36-45	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
9381980-26	1997	Quercetin down-regulated the expression of c-myc and Ki-ras oncogenes and led to induced differentiation and apoptosis in K562 cells.	Quercetin	0-9	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	43-48
9381980-26	1997	Quercetin down-regulated the expression of c-myc and Ki-ras oncogenes and led to induced differentiation and apoptosis in K562 cells.	Quercetin	0-9	KRAS proto-oncogene, GTPase	Homo sapiens	53-59
9366512-6	1997	On the contrary, serosal addition of quercetin was devoid of secretory activity and at concentration of 10 microM it was able to inhibit chloride secretion in response to carbachol, prostaglandin E2 and PMA/W13, but not that induced by VIP.	Quercetin	37-46	vasoactive intestinal peptide	Homo sapiens	236-239
8951155-2	1996	A potent inhibitor of insulin receptor tyrosine kinase, quercetin, inhibited the vanadate-increasing effect on the LPL activity in fat pads, but did not inhibit the vanadate-stimulated release of LPL activity from the fat pads.	Quercetin	56-65	lipoprotein lipase	Rattus norvegicus	115-118
9563007-5	1997	Quercetin and genistein block the phosphatidylinositol conversion to IP3 signal transduction pathway mainly by inhibiting 1-phosphatidylinositol 4-kinase (PI kinase, EC 2.7.1.67) and 1-phosphatidylinositol 4-phosphate 5-kinase (PIP kinase, EC 2.7.1.68), respectively.	Quercetin	0-9	phosphatidylinositol-5-phosphate 4-kinase type 2 alpha	Homo sapiens	183-226
9563007-5	1997	Quercetin and genistein block the phosphatidylinositol conversion to IP3 signal transduction pathway mainly by inhibiting 1-phosphatidylinositol 4-kinase (PI kinase, EC 2.7.1.67) and 1-phosphatidylinositol 4-phosphate 5-kinase (PIP kinase, EC 2.7.1.68), respectively.	Quercetin	0-9	phosphatidylinositol-5-phosphate 4-kinase type 2 alpha	Homo sapiens	228-238
9454378-1	1997	The character of structural rearrangements in leukocyte membranes affected by 5-lipoxygenase inhibitors: quercetin and linoleic acid hydroxamate, has been investigated.	Quercetin	105-114	arachidonate 5-lipoxygenase	Homo sapiens	78-92
9042300-14	1996	Down-regulation (by tiazofurin) or inhibition of PI and PIP kinase activities (by quercetin) in human carcinoma cells led to a marked reduction of IP3 concentration and to cell death.	Quercetin	82-91	prolactin induced protein	Homo sapiens	56-59
9021685-5	1996	We postulate that quercetin exerts its growth inhibitory action by interaction with type II estrogen binding sites and subsequent induction of Transforming Growth Factor-beta 1 expression and secretion.	Quercetin	18-27	transforming growth factor beta 1	Homo sapiens	143-176
8937850-11	1996	In addition, the inhibition of acetaminophen sulfonation by quercetin was very similar for His-P-PST and P-PST, with IC50 values of 0.10 +/- 0.03 and 0.05 +/- 0.01 microM (NS), respectively.	Quercetin	60-69	sulfotransferase family 1A member 1	Homo sapiens	95-100
8937850-11	1996	In addition, the inhibition of acetaminophen sulfonation by quercetin was very similar for His-P-PST and P-PST, with IC50 values of 0.10 +/- 0.03 and 0.05 +/- 0.01 microM (NS), respectively.	Quercetin	60-69	sulfotransferase family 1A member 1	Homo sapiens	105-110
8895505-4	1996	To further elucidate this dual role, we investigated the influence of apigenin, luteolin and quercetin on the tumour suppressor protein p53, regarding p53 accumulation, cell cycle arrest, apoptosis, and biological activity.	Quercetin	93-102	tumor protein p53	Homo sapiens	136-139
8798712-2	1996	Stimulation of Ca2+ATPase was observed at low quercetin concentrations (&lt;25 microM) followed by inhibition at higher concentrations.	Quercetin	46-55	carbonic anhydrase 2	Homo sapiens	15-25
8798712-6	1996	Quercetin increased the calcium sensitivity of the Ca2+ATPase like that observed with phosphorylation of phospholamban or treatment with monoclonal antibody 1D11.	Quercetin	0-9	carbonic anhydrase 2	Homo sapiens	51-61
8798712-8	1996	Quercetin, even under stimulatory conditions, was a competitive inhibitor of ATP, but appears to relieve the Ca2+ATPase from phospholamban inhibition, thereby, producing an activation.	Quercetin	0-9	carbonic anhydrase 2	Homo sapiens	109-119
8798712-9	1996	The subsequent inhibitory action of higher quercetin concentrations results from competition of quercetin with the nucleotide binding site of the Ca2+ATPase.	Quercetin	43-52	carbonic anhydrase 2	Homo sapiens	146-156
8798712-9	1996	The subsequent inhibitory action of higher quercetin concentrations results from competition of quercetin with the nucleotide binding site of the Ca2+ATPase.	Quercetin	96-105	carbonic anhydrase 2	Homo sapiens	146-156
8798712-10	1996	The data suggest that quercetin interacts with the nucleotide binding site to mask phospholamban"s inhibition of the SR Ca2+ATPase and suggests that phospholamban may interact at or near the nucleotide binding site.	Quercetin	22-31	carbonic anhydrase 2	Homo sapiens	120-130
8792656-6	1996	Using the same conditions the unmetabolized quercetin showed an inhibition of chemiluminescence by 74% (FMLP), resp. 20% (opsonized zymosan).	Quercetin	44-53	formyl peptide receptor 1	Homo sapiens	104-108
9863170-6	1996	Que 0.5-50 mumol.L-1 markedly increased the amount of cGMP in HUVEC stimulated with thrombin and activated platelets.	Quercetin	0-3	coagulation factor II, thrombin	Homo sapiens	84-92
8858562-4	1996	The rat lens enzyme present in fresh homogenate as well as after 100 fold purification was found to utilize L-threose with a km of 7.1 x 10(-4) M. The specificity of the reaction was affirmed by its inhibition with sorbinil and quercetin, the well known aldose reductase inhibitors.	Quercetin	228-237	aldo-keto reductase family 1 member B1	Rattus norvegicus	254-270
8665487-1	1996	The effects of three representative flavonoids, quercetin, myricetin and kaempferol, on the nuclear antioxidant defense glutathione (GSH) and glutathione S-transferase (GST) were investigated in a model system of isolated rat liver nuclei.	Quercetin	48-57	hematopoietic prostaglandin D synthase	Rattus norvegicus	142-167
8665487-1	1996	The effects of three representative flavonoids, quercetin, myricetin and kaempferol, on the nuclear antioxidant defense glutathione (GSH) and glutathione S-transferase (GST) were investigated in a model system of isolated rat liver nuclei.	Quercetin	48-57	hematopoietic prostaglandin D synthase	Rattus norvegicus	169-172
8688318-7	1996	In order to transfer these data to tumour cells constitutively expressing stress hsp70 due to the constitutive activity of the original hsp70 promoter we sought to supress the heat shock response pathway by the natural flavonoid quercetin, known to inactivate the heat shock transcription factor (HSF).	Quercetin	229-238	heat shock protein family A (Hsp70) member 4	Homo sapiens	136-141
8688318-7	1996	In order to transfer these data to tumour cells constitutively expressing stress hsp70 due to the constitutive activity of the original hsp70 promoter we sought to supress the heat shock response pathway by the natural flavonoid quercetin, known to inactivate the heat shock transcription factor (HSF).	Quercetin	229-238	interleukin 6	Homo sapiens	264-295
8688318-7	1996	In order to transfer these data to tumour cells constitutively expressing stress hsp70 due to the constitutive activity of the original hsp70 promoter we sought to supress the heat shock response pathway by the natural flavonoid quercetin, known to inactivate the heat shock transcription factor (HSF).	Quercetin	229-238	interleukin 6	Homo sapiens	297-300
8688318-10	1996	Concomitantly, hsp70 expression was strongly down-regulated under quercetin treatment.	Quercetin	66-75	heat shock protein family A (Hsp70) member 4	Homo sapiens	15-20
8688318-11	1996	Our data indicate that quercetin may be useful as a sensitiser in chemotherapeutically treated patients suffering from hsp70-overexpressing tumours.	Quercetin	23-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	119-124
8688318-0	1996	Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy.	Quercetin	121-130	heat shock protein family A (Hsp70) member 4	Homo sapiens	75-80
8627784-6	1996	rATP-dependent release of pTP from the NM was inhibited in a dose-dependent fashion by the addition of tyrosine kinase inhibitors, such as quercetin, methyl-2,5-dihydroxycinnamate, or genistein.	Quercetin	139-148	TXK tyrosine kinase	Homo sapiens	103-118
8704306-3	1996	Quercetin and baicalein showed a competitive inhibition pattern vs. NADP+ for NADP-ME, and a similar model for both flavonoids vs. phosphoenolpyruvate (PEP) was observed when tested on PEPCase.	Quercetin	0-9	malic enzyme 1	Homo sapiens	78-85
8704306-4	1996	K(i) for NADP-ME inhibition at pH 7.0 were 0.83 microM and 1.54 microM for quercetin and baicalein, respectively.	Quercetin	75-84	malic enzyme 1	Homo sapiens	9-16
8704306-5	1996	K(i) for PEPCase inhibition were 0.17 microM and 0.79 microM (quercetin and baicalein, respectively), indicating that these compounds are the most potent inhibitors described for this carboxylase.	Quercetin	62-71	phosphoenolpyruvate carboxykinase 1	Homo sapiens	9-16
8627784-6	1996	rATP-dependent release of pTP from the NM was inhibited in a dose-dependent fashion by the addition of tyrosine kinase inhibitors, such as quercetin, methyl-2,5-dihydroxycinnamate, or genistein.	Quercetin	139-148	protein tyrosine phosphatase receptor type U	Homo sapiens	26-29
9812753-0	1996	Inhibitory effect of quercetin on tumor necrosis factor and interleukin-1 beta pro-osteoclastic activities.	Quercetin	21-30	tumor necrosis factor	Homo sapiens	34-55
9812753-0	1996	Inhibitory effect of quercetin on tumor necrosis factor and interleukin-1 beta pro-osteoclastic activities.	Quercetin	21-30	interleukin 1 beta	Homo sapiens	60-78
9812753-1	1996	AIM: To study the effects of quercetin on tumor necrosis factor (TNF) and interleukin-1 beta (IL-1 beta) pro-osteoclastic activities.	Quercetin	29-38	tumor necrosis factor	Homo sapiens	42-63
9812753-1	1996	AIM: To study the effects of quercetin on tumor necrosis factor (TNF) and interleukin-1 beta (IL-1 beta) pro-osteoclastic activities.	Quercetin	29-38	tumor necrosis factor	Homo sapiens	65-68
9812753-1	1996	AIM: To study the effects of quercetin on tumor necrosis factor (TNF) and interleukin-1 beta (IL-1 beta) pro-osteoclastic activities.	Quercetin	29-38	interleukin 1 beta	Homo sapiens	74-92
9812753-1	1996	AIM: To study the effects of quercetin on tumor necrosis factor (TNF) and interleukin-1 beta (IL-1 beta) pro-osteoclastic activities.	Quercetin	29-38	interleukin 1 beta	Homo sapiens	94-103
9812753-3	1996	RESULTS: Quercetin 5-40 mumol.L-1 reduced the inhibition of cell proliferation and AIP activity induced by TNF or IL-1 beta in a concentration-dependent manner.	Quercetin	9-18	tumor necrosis factor	Homo sapiens	107-110
9812753-3	1996	RESULTS: Quercetin 5-40 mumol.L-1 reduced the inhibition of cell proliferation and AIP activity induced by TNF or IL-1 beta in a concentration-dependent manner.	Quercetin	9-18	interleukin 1 beta	Homo sapiens	114-123
9812753-5	1996	CONCLUSION: quercetin exerted a marked inhibitory effect on TNF and IL-1 activities, related to their pro-osteoclastic function.	Quercetin	12-21	tumor necrosis factor	Homo sapiens	60-63
9812753-5	1996	CONCLUSION: quercetin exerted a marked inhibitory effect on TNF and IL-1 activities, related to their pro-osteoclastic function.	Quercetin	12-21	interleukin 1 beta	Homo sapiens	68-72
9816216-12	1996	In 9 of 11 patients, lymphocyte protein tyrosine phosphorylation was inhibited following administration of quercetin at 1 h, which persisted to 16 h. In one patient with ovarian cancer refractory to cisplatin, following two courses of quercetin (420 mg/m2), the CA 125 had fallen from 295 to 55 units/ml, and in another patient with hepatoma, the serum alpha-fetoprotein fell.	Quercetin	107-116	alpha fetoprotein	Homo sapiens	353-370
8928743-13	1996	However, PMA blocked inhibition of protein kinase C (PKC) and secretion by quercetin, suggesting that PA formed by PLD supports PKC activation and GTP gamma S-induced secretion.	Quercetin	75-84	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	115-118
8928743-16	1996	This is the first report of a Ca(2+)-independent PLA2 activity in human platelets, use of quercetin as a PLD inhibitor, and dissociation of PLA2, PLC, and PLD activities from secretion.	Quercetin	90-99	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	105-108
8611183-4	1996	In contrast, the addition of quercetin (an inhibitor of aldehyde reductase) in an attempt to diminish methional reduction increased apoptosis in both BAF3 b0 and BAF3 bcl2 cells.	Quercetin	29-38	B cell leukemia/lymphoma 2	Mus musculus	167-171
8720382-1	1996	Flavonols like quercetin, myricetin, and kaempferol inhibit the activity of the adenosine deaminase of endothelial cells (IC50 between 26 and 32 mumol/l), while flavones are inactive.	Quercetin	15-24	adenosine deaminase	Homo sapiens	80-99
9206266-1	1996	The effects of protein kinase C(PKC) inhibitors 1-(5-isoquino-linylsulfonyl)-2-methylpeperazine (H-7) and quercetin on tumor necrosis factor (TNF) were studied in cultured bovine pulmonary artery endothelial cells (BPAEC) in vitro.	Quercetin	106-115	tumor necrosis factor	Bos taurus	119-140
8576124-0	1996	Inhibition of catechol O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by quercetin.	Quercetin	99-108	catechol O-methyltransferase	Mesocricetus auratus	14-42
8576124-3	1996	In this study, we examined the mechanism of inhibition by quercetin of the catechol O-methyltransferase-catalyzed O-methylation of catecholestrogens as a basis for the previously reported enhancement of estradiol-induced tumorigenesis by this flavonoid.	Quercetin	58-67	catechol O-methyltransferase	Mesocricetus auratus	75-103
8725009-6	1996	Also, quercetin, a bioflavenoid that inhibits the insulin receptor tyrosine kinase activity, inhibits the actions of both histone H4 and insulin.	Quercetin	6-15	insulin receptor	Rattus norvegicus	50-66
8725009-6	1996	Also, quercetin, a bioflavenoid that inhibits the insulin receptor tyrosine kinase activity, inhibits the actions of both histone H4 and insulin.	Quercetin	6-15	histone cluster 2, H4	Rattus norvegicus	122-132
8548766-5	1996	Quercetin was found to inhibit hsp70 synthesis for a period of 3-6 h after PGA1 treatment.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	31-36
8548766-7	1996	After the initial delay, hsp70 synthesis reached the same rate as the PGA1-treated control, and it was actually prolonged in the presence of quercetin.	Quercetin	141-150	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
8548766-8	1996	In PGA1-treated cells, quercetin suppressed PGA1-induced thermotolerance completely if the heat shock was applied at a time (6 h) when hsp70 synthesis was inhibited, whereas it could not prevent the establishment of a thermotolerant state if the heat challenge was applied 24 h after treatment, when hsp70 synthesis was not affected.	Quercetin	23-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	135-140
8548766-8	1996	In PGA1-treated cells, quercetin suppressed PGA1-induced thermotolerance completely if the heat shock was applied at a time (6 h) when hsp70 synthesis was inhibited, whereas it could not prevent the establishment of a thermotolerant state if the heat challenge was applied 24 h after treatment, when hsp70 synthesis was not affected.	Quercetin	23-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	300-305
12237684-0	1996	The regulation of N-Acetylglucosaminyl Transferase III by Protein Kinase C. The activity of N-acetylglucosaminyl transferase III (GnT III) in 7721 human heptocarcinoma cell was inhibited by two non-specific Ser/Thr protein kinase inhibitors, quercetin and trifluoperazine, and two PKC specific inhibitors, D-sphingosine and staurosporine.	Quercetin	242-251	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	130-137
12237684-2	1996	Quercetin, D-sphingosine and staurosporine also blocked the PMA activation of GnT-III.	Quercetin	0-9	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	78-85
12237684-3	1996	The inhibitory effects on m-PKC and GnT III were generally proportional to the concentration of quercetin and staurosporine.	Quercetin	96-105	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	36-43
8548766-4	1996	Because quercetin was shown to modulate hsp70 expression after heat shock in K562 cells, we have investigated the effect of this flavonoid on HSF activation, hsp70 synthesis, and thermotolerance in human K562 cells after induction with PGA1.	Quercetin	8-17	heat shock protein family A (Hsp70) member 4	Homo sapiens	40-45
8924586-4	1996	Inhibition by the more potent compounds, fisetin, kaempferol, naringenin, and quercetin, which contain a resorcinol moiety, was consistent with mechanism-based inactivation of TPO as previously observed for resorcinol and derivatives.	Quercetin	78-87	thyroid peroxidase	Homo sapiens	176-179
9206266-4	1996	The IC50 of H-7 and quercetin was 9.7 and 10.8 mumol.L-1 for the inhibition of LDH% release; 19.5 and 16.7 mumol.L-1 for the inhibition of TNF-induced PMN-EC adhesion; 7.0 and 6.1 mumol.L-1 for TNF-induced inhibition of DNA synthesis and 8.7 and 11.36 mumol.L-1 for proliferation.	Quercetin	20-29	LDH	Bos taurus	79-82
9206266-4	1996	The IC50 of H-7 and quercetin was 9.7 and 10.8 mumol.L-1 for the inhibition of LDH% release; 19.5 and 16.7 mumol.L-1 for the inhibition of TNF-induced PMN-EC adhesion; 7.0 and 6.1 mumol.L-1 for TNF-induced inhibition of DNA synthesis and 8.7 and 11.36 mumol.L-1 for proliferation.	Quercetin	20-29	tumor necrosis factor	Bos taurus	139-142
9206266-4	1996	The IC50 of H-7 and quercetin was 9.7 and 10.8 mumol.L-1 for the inhibition of LDH% release; 19.5 and 16.7 mumol.L-1 for the inhibition of TNF-induced PMN-EC adhesion; 7.0 and 6.1 mumol.L-1 for TNF-induced inhibition of DNA synthesis and 8.7 and 11.36 mumol.L-1 for proliferation.	Quercetin	20-29	tumor necrosis factor	Bos taurus	194-197
9206266-5	1996	These results suggest that PKC inhibitors H-7 and quercetin protect BPAEC from TNF induced injuries and PKC play an important role in EC activation by TNF.	Quercetin	50-59	tumor necrosis factor	Bos taurus	79-82
8745575-3	1995	It was found that even though quercetin could specifically inhibit the expression of hsp90 alpha and hsp70 mRNA, it could not prevent GR from the decrease in response to the heat shock treatment.	Quercetin	30-39	heat shock protein 90 alpha family class A member 1	Homo sapiens	85-96
8748153-2	1995	Quercetin, a non-specific inhibitor of Ser/Thr protein kinase, and D-sphingosine and staurosporine, two specific inhibitors of PKC, blocked the activation of membranous PKC and GnT-V by PMA.	Quercetin	0-9	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	177-182
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Quercetin	141-150	interleukin 1 alpha	Homo sapiens	42-55
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Quercetin	141-150	interleukin 6	Homo sapiens	69-82
8745575-3	1995	It was found that even though quercetin could specifically inhibit the expression of hsp90 alpha and hsp70 mRNA, it could not prevent GR from the decrease in response to the heat shock treatment.	Quercetin	30-39	heat shock protein family A (Hsp70) member 4	Homo sapiens	101-106
8745575-10	1995	It was found for the first time that quercetin could down-regulate GR in a time-dependent manner significantly, and that the down-regulation of GR by quercetin in HOS-8603 cells paralelled with a decrease in glucocorticoid-mediated functional responses, suggesting that the down-regulation of GR by quercetin is of biological significance.	Quercetin	37-46	nuclear receptor subfamily 3 group C member 1	Homo sapiens	67-69
8745575-10	1995	It was found for the first time that quercetin could down-regulate GR in a time-dependent manner significantly, and that the down-regulation of GR by quercetin in HOS-8603 cells paralelled with a decrease in glucocorticoid-mediated functional responses, suggesting that the down-regulation of GR by quercetin is of biological significance.	Quercetin	150-159	nuclear receptor subfamily 3 group C member 1	Homo sapiens	144-146
8745575-10	1995	It was found for the first time that quercetin could down-regulate GR in a time-dependent manner significantly, and that the down-regulation of GR by quercetin in HOS-8603 cells paralelled with a decrease in glucocorticoid-mediated functional responses, suggesting that the down-regulation of GR by quercetin is of biological significance.	Quercetin	150-159	nuclear receptor subfamily 3 group C member 1	Homo sapiens	144-146
8745575-10	1995	It was found for the first time that quercetin could down-regulate GR in a time-dependent manner significantly, and that the down-regulation of GR by quercetin in HOS-8603 cells paralelled with a decrease in glucocorticoid-mediated functional responses, suggesting that the down-regulation of GR by quercetin is of biological significance.	Quercetin	150-159	nuclear receptor subfamily 3 group C member 1	Homo sapiens	144-146
8745575-10	1995	It was found for the first time that quercetin could down-regulate GR in a time-dependent manner significantly, and that the down-regulation of GR by quercetin in HOS-8603 cells paralelled with a decrease in glucocorticoid-mediated functional responses, suggesting that the down-regulation of GR by quercetin is of biological significance.	Quercetin	150-159	nuclear receptor subfamily 3 group C member 1	Homo sapiens	144-146
7642697-5	1995	The activity of Vps34p kinase is significantly reduced by the PI 3-kinase inhibitors wortmannin, a fungal metabolite, and LY294002, a quercetin analog (Stack, J. H., and S. D. Emr.	Quercetin	134-143	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	16-22
8572604-6	1995	The bioflavonoid, quercetin, a non-specific tyrosine protein kinase inhibitor, at a concentration of 30 microM completely abolished the action of interferon-gamma on thymidine incorporation.	Quercetin	18-27	interferon gamma	Homo sapiens	146-162
7780149-5	1995	(1) Quercetin-sensitive leukemic blasts, when treated with quercetin, secrete large amounts of TGF-beta 1 in the medium and show positivity for TGF-beta 1-immunoreactive material in the cytoplasm.	Quercetin	59-68	transforming growth factor beta 1	Homo sapiens	95-105
7648427-9	1995	In cells cultured directly on collagen I, staurosporine, quercetin and 6-dimethylaminopurine strongly inhibited prolactin action of alpha S1-casein gene whereas herbimycin A was only partly inhibitory.	Quercetin	57-66	alpha-S1-casein	Oryctolagus cuniculus	132-147
7648427-12	1995	The induction of transferrin gene by the extracellular matrix was inhibited slightly by quercetin.	Quercetin	88-97	serotransferrin	Oryctolagus cuniculus	17-28
7780149-0	1995	Quercetin inhibits the growth of leukemic progenitors and induces the expression of transforming growth factor-beta 1 in these cells.	Quercetin	0-9	transforming growth factor beta 1	Homo sapiens	84-117
7780149-3	1995	In the present report, we show that the induction of transforming growth factor-beta 1 (TGF-beta 1) in leukemic blasts is one of the growth-inhibitory mechanisms of quercetin in these cells.	Quercetin	165-174	transforming growth factor beta 1	Homo sapiens	53-86
7780149-3	1995	In the present report, we show that the induction of transforming growth factor-beta 1 (TGF-beta 1) in leukemic blasts is one of the growth-inhibitory mechanisms of quercetin in these cells.	Quercetin	165-174	transforming growth factor beta 1	Homo sapiens	88-98
7780149-5	1995	(1) Quercetin-sensitive leukemic blasts, when treated with quercetin, secrete large amounts of TGF-beta 1 in the medium and show positivity for TGF-beta 1-immunoreactive material in the cytoplasm.	Quercetin	59-68	transforming growth factor beta 1	Homo sapiens	144-154
7780149-5	1995	(1) Quercetin-sensitive leukemic blasts, when treated with quercetin, secrete large amounts of TGF-beta 1 in the medium and show positivity for TGF-beta 1-immunoreactive material in the cytoplasm.	Quercetin	4-13	transforming growth factor beta 1	Homo sapiens	95-105
7780149-5	1995	(1) Quercetin-sensitive leukemic blasts, when treated with quercetin, secrete large amounts of TGF-beta 1 in the medium and show positivity for TGF-beta 1-immunoreactive material in the cytoplasm.	Quercetin	4-13	transforming growth factor beta 1	Homo sapiens	144-154
7780149-6	1995	(2) At a concentration of 8 mumol/L, antisense TGF-beta 1 oligonucleotides prevent the growth-inhibitory action of quercetin.	Quercetin	115-124	transforming growth factor beta 1	Homo sapiens	47-57
7780149-7	1995	(3) Anti-TGF-beta 1 neutralizing monoclonal antibodies can prevent almost completely the growth-inhibitory activity of quercetin.	Quercetin	119-128	transforming growth factor beta 1	Homo sapiens	9-19
7780149-8	1995	The analysis of quercetin-resistant cases confirmed as well the central role of TGF-beta 1 in the growth-inhibitory activity of quercetin.	Quercetin	16-25	transforming growth factor beta 1	Homo sapiens	80-90
7780149-8	1995	The analysis of quercetin-resistant cases confirmed as well the central role of TGF-beta 1 in the growth-inhibitory activity of quercetin.	Quercetin	128-137	transforming growth factor beta 1	Homo sapiens	80-90
7780149-9	1995	In conclusion, quercetin can act as a cytostatic agent for leukemic cells by modulating the production of TGF-beta 1.	Quercetin	15-24	transforming growth factor beta 1	Homo sapiens	106-116
7702609-0	1995	Quercetin suppresses heat shock response by down regulation of HSF1.	Quercetin	0-9	heat shock transcription factor 1	Homo sapiens	63-67
7669110-6	1995	Trifluoperazine (0.1 mM), which impairs the capacity of calmodulin to activate Ca(2+)-ATPase, substantially inhibited transport, as did quercetin (10 mM) and vanadate (10 microM), inhibitors of Ca(2+)-ATPases.	Quercetin	136-145	calmodulin 2	Gallus gallus	56-66
7660815-3	1995	RESULTS: Que inhibited the platelet aggregation and the rise of [Ca2+]i induced by thrombin in platelets.	Quercetin	9-12	coagulation factor II, thrombin	Homo sapiens	83-91
7554275-5	1995	trans-Resveratrol and quercetin demonstrated a dose-dependent inhibition of both thrombin-induced and ADP-induced platelet aggregation, whereas ethanol inhibited only thrombin-induced aggregation.	Quercetin	22-31	coagulation factor II, thrombin	Homo sapiens	81-89
7660815-5	1995	The inhibitory effects of Que on platelet aggregation induced by thrombin were reduced by adding calcium to the medium, and Que had no effect on thrombin-induced internal Ca2+ release from dense tubular system.	Quercetin	26-29	coagulation factor II, thrombin	Homo sapiens	65-73
7702609-6	1995	These data suggest that (1) quercetin does not affect the trimer formation of HSF1, and (2) the decline of the HSF1-HSE complex might be linked to the decrease of HSF1 levels caused by quercetin.	Quercetin	185-194	heat shock transcription factor 1	Homo sapiens	111-115
7702609-6	1995	These data suggest that (1) quercetin does not affect the trimer formation of HSF1, and (2) the decline of the HSF1-HSE complex might be linked to the decrease of HSF1 levels caused by quercetin.	Quercetin	185-194	heat shock transcription factor 1	Homo sapiens	111-115
7702609-2	1995	After treatment of cells with nonlethal concentrations of quercetin, the binding of heat shock factor (HSF) to the heat shock element (HSE) was inhibited as detected by gel shift assay.	Quercetin	58-67	interleukin 6	Homo sapiens	84-101
7702609-2	1995	After treatment of cells with nonlethal concentrations of quercetin, the binding of heat shock factor (HSF) to the heat shock element (HSE) was inhibited as detected by gel shift assay.	Quercetin	58-67	interleukin 6	Homo sapiens	103-106
7702609-3	1995	We examined whether quercetin inhibits heat shock response by inhibiting HSF trimer-formation and found it was not the case.	Quercetin	20-29	interleukin 6	Homo sapiens	73-76
7702609-4	1995	Instead, pretreatment of the cells with quercetin caused a decrease in the level of HSF1, especially of the constitutively phosphorylated form.	Quercetin	40-49	heat shock transcription factor 1	Homo sapiens	84-88
7878664-7	1995	Linoleic acid-dependent covalent binding of phenytoin was inhibited in a concentration-dependent fashion by the selective and nonselective LPO/PHS inhibitors indomethacin, nordihydroguaiaretic acid, quercetin, BW755C, and 5,8,11,14-eicosatetraynoic acid (ETYA) and by the hydroperoxidase inhibitor methimazole (p &lt; 0.05).	Quercetin	199-208	lactoperoxidase	Mus musculus	139-142
7878664-7	1995	Linoleic acid-dependent covalent binding of phenytoin was inhibited in a concentration-dependent fashion by the selective and nonselective LPO/PHS inhibitors indomethacin, nordihydroguaiaretic acid, quercetin, BW755C, and 5,8,11,14-eicosatetraynoic acid (ETYA) and by the hydroperoxidase inhibitor methimazole (p &lt; 0.05).	Quercetin	199-208	pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1	Mus musculus	143-146
7634387-0	1995	Quercetin not only inhibits P-glycoprotein efflux activity but also inhibits CYP3A isozymes.	Quercetin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	77-82
7870067-3	1995	Both the flavonoid quercetin and phloretin inhibited the expression of IL-1 alpha/beta as well as TNF-alpha mRNA, with quercetin being more potent than phloretin and TNF-alpha expression somewhat more sensitive than that of IL-1 alpha/beta.	Quercetin	19-28	interleukin 1 alpha	Mus musculus	71-81
7870067-3	1995	Both the flavonoid quercetin and phloretin inhibited the expression of IL-1 alpha/beta as well as TNF-alpha mRNA, with quercetin being more potent than phloretin and TNF-alpha expression somewhat more sensitive than that of IL-1 alpha/beta.	Quercetin	19-28	tumor necrosis factor	Mus musculus	98-107
7870067-3	1995	Both the flavonoid quercetin and phloretin inhibited the expression of IL-1 alpha/beta as well as TNF-alpha mRNA, with quercetin being more potent than phloretin and TNF-alpha expression somewhat more sensitive than that of IL-1 alpha/beta.	Quercetin	19-28	tumor necrosis factor	Mus musculus	166-175
7870067-3	1995	Both the flavonoid quercetin and phloretin inhibited the expression of IL-1 alpha/beta as well as TNF-alpha mRNA, with quercetin being more potent than phloretin and TNF-alpha expression somewhat more sensitive than that of IL-1 alpha/beta.	Quercetin	19-28	interleukin 1 alpha	Mus musculus	224-234
8588487-0	1995	EF-1 alpha is a target site for an inhibitory effect of quercetin in the peptide elongation process.	Quercetin	56-65	eukaryotic translation elongation factor 1 alpha 1	Rattus norvegicus	0-10
8588487-2	1995	Quercetin inhibited [14C]leucine incorporation into proteins in vitro and the inhibitory effect is being directed towards the elongation factor eEF-1, but not to eEF-2 and ribosomes.	Quercetin	0-9	eukaryotic translation elongation factor 1 alpha 1	Rattus norvegicus	144-149
8588487-3	1995	Quercetin was found to form a complex with EF-1 alpha, which was inactive in GTP-dependent binding to ribosomes.	Quercetin	0-9	eukaryotic translation elongation factor 1 alpha 1	Rattus norvegicus	43-53
8588487-4	1995	It can be suggested that quercetin can block the total or the part of the domain of EF-1 alpha structure that is responsible for formation of the ternary complex EF-1 alpha-GTP-[14C]Phe-tRNA and therefore preventing formation of the quaternary complex with ribosomes.	Quercetin	25-34	eukaryotic translation elongation factor 1 alpha 1	Rattus norvegicus	84-94
7853360-10	1994	In this model, TCDD"s effects on ADA activity were antagonized by known protein kinase or phosphorylation inhibitors such as quercetin, genistein, tyrphostin, and neomycin.	Quercetin	125-134	adenosine deaminase	Mus musculus	33-36
8777434-7	1995	The spontaneous transformation of the c-fos-transfected REL cells was associated with the appearance of c-fos/AP1 complexes binding TRE, suggesting that c-fos/AP1 complexes are involved in the antitransforming mechanism of quercetin.	Quercetin	223-232	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-43
8777434-7	1995	The spontaneous transformation of the c-fos-transfected REL cells was associated with the appearance of c-fos/AP1 complexes binding TRE, suggesting that c-fos/AP1 complexes are involved in the antitransforming mechanism of quercetin.	Quercetin	223-232	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	104-109
8777434-7	1995	The spontaneous transformation of the c-fos-transfected REL cells was associated with the appearance of c-fos/AP1 complexes binding TRE, suggesting that c-fos/AP1 complexes are involved in the antitransforming mechanism of quercetin.	Quercetin	223-232	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-113
8777434-7	1995	The spontaneous transformation of the c-fos-transfected REL cells was associated with the appearance of c-fos/AP1 complexes binding TRE, suggesting that c-fos/AP1 complexes are involved in the antitransforming mechanism of quercetin.	Quercetin	223-232	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	104-109
8777434-7	1995	The spontaneous transformation of the c-fos-transfected REL cells was associated with the appearance of c-fos/AP1 complexes binding TRE, suggesting that c-fos/AP1 complexes are involved in the antitransforming mechanism of quercetin.	Quercetin	223-232	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	159-162
8069862-10	1994	The synthesis of HSP70 was inhibited by quercetin when determined by immunocytochemistry, Western blot analysis, and Northern blot analysis.	Quercetin	40-49	heat shock protein family A (Hsp70) member 4	Homo sapiens	17-22
8069862-13	1994	In addition, pretreatment of tumor cells with HSP70 antisense oligomer that specifically inhibited the synthesis of HSP70 enhanced the subsequent induction of apoptosis by quercetin.	Quercetin	172-181	heat shock protein family A (Hsp70) member 4	Homo sapiens	46-51
8069862-13	1994	In addition, pretreatment of tumor cells with HSP70 antisense oligomer that specifically inhibited the synthesis of HSP70 enhanced the subsequent induction of apoptosis by quercetin.	Quercetin	172-181	heat shock protein family A (Hsp70) member 4	Homo sapiens	116-121
8069862-14	1994	These results suggest that quercetin displays antitumor activity by triggering apoptosis and that HSP70 may affect quercetin-induced apoptosis.	Quercetin	115-124	heat shock protein family A (Hsp70) member 4	Homo sapiens	98-103
7845388-1	1994	Previous studies have shown that a combination of low pH and quercetin (QCT) treatment following heat shock markedly suppresses and delays the expression of heat shock protein genes, particularly the HSP70 gene (Lee et al., Biochem.	Quercetin	61-70	heat shock protein family A (Hsp70) member 4	Homo sapiens	200-205
8189235-4	1994	When the cells were treated with quercetin or antisense oligodeoxyribonucleotide against hsp72 cDNA, the synthesis of hsp72 was not induced by heat shock, whereas bradykinin-induced [Ca2+]i rise was abolished and the [Ca2+]i rise was not restored.	Quercetin	33-42	heat shock protein 1A	Mus musculus	118-123
8055642-3	1994	By using UV spectroscopic and fluorescence quenching experiments we show that quercetin binds to bovine serum albumin and that the complex does, in the presence of Cu(II), lead to fragmentation of the protein.	Quercetin	78-87	albumin	Homo sapiens	104-117
7948413-5	1994	A change in the medium osmolality in the presence of the 5-lipoxygenase inhibitor quercetin did not result in the modification of the concentration dependence of CL inhibition induced by any of the activators.	Quercetin	82-91	arachidonate 5-lipoxygenase	Homo sapiens	57-71
8189235-7	1994	In the presence of quercetin or antisense oligodeoxyribonucleotide, IP3 receptor binding activity decreased and reached 27.2% of the control 12 h after heat shock.	Quercetin	19-28	inositol 1,4,5-triphosphate receptor 3	Mus musculus	68-80
8203931-1	1994	The mutagenicity of quercetin, a flavonoid, was examined by means of DNA fingerprint analysis using the Pc-1 and Pc-2 minisatellite probes that efficiently detect mutations due to recombination.	Quercetin	20-29	proprotein convertase subtilisin/kexin type 1	Homo sapiens	104-108
8198534-4	1994	Because inhibitors of HSP70 synthesis could be an important tool with which to study the function of this protein, we have investigated the effect of quercetin, a flavonoid with antiproliferative activity which is widely distributed in nature, on HSP70 synthesis in human K562 erythroleukaemia cells after treatment with severe or mild heat shock and with other inducers.	Quercetin	150-159	heat shock protein family A (Hsp70) member 4	Homo sapiens	247-252
8198534-5	1994	Quercetin was found to affect HSP70 synthesis at more than one level, depending on the conditions used.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	30-35
8198534-6	1994	Indeed, after severe heat shock (45 degrees C for 20 min) treatment with quercetin, at non-toxic concentrations, was found to inhibit HSP70 synthesis for a period of 3-4 h. This block appeared to be exerted at the post-transcriptional level and to be cell-mediated, as the addition of quercetin during translation of HSP70 mRNA in vitro had no effect.	Quercetin	73-82	heat shock protein family A (Hsp70) member 4	Homo sapiens	134-139
8198534-6	1994	Indeed, after severe heat shock (45 degrees C for 20 min) treatment with quercetin, at non-toxic concentrations, was found to inhibit HSP70 synthesis for a period of 3-4 h. This block appeared to be exerted at the post-transcriptional level and to be cell-mediated, as the addition of quercetin during translation of HSP70 mRNA in vitro had no effect.	Quercetin	73-82	heat shock protein family A (Hsp70) member 4	Homo sapiens	317-322
8198534-6	1994	Indeed, after severe heat shock (45 degrees C for 20 min) treatment with quercetin, at non-toxic concentrations, was found to inhibit HSP70 synthesis for a period of 3-4 h. This block appeared to be exerted at the post-transcriptional level and to be cell-mediated, as the addition of quercetin during translation of HSP70 mRNA in vitro had no effect.	Quercetin	285-294	heat shock protein family A (Hsp70) member 4	Homo sapiens	134-139
8198534-7	1994	After prolonged (90 min) exposure at 43 degrees C, however, quercetin was found to inhibit also HSP70 mRNA transcription.	Quercetin	60-69	heat shock protein family A (Hsp70) member 4	Homo sapiens	96-101
8198534-9	1994	Under all conditions tested, the quercetin-induced block of HSP70 synthesis was found to be transient and, after an initial delay, synthesis of HSP70 reached the control rate and continued at the same level for several hours after the time at which HSP70 synthesis had been turned off in control cells.	Quercetin	33-42	heat shock protein family A (Hsp70) member 4	Homo sapiens	60-65
8198534-9	1994	Under all conditions tested, the quercetin-induced block of HSP70 synthesis was found to be transient and, after an initial delay, synthesis of HSP70 reached the control rate and continued at the same level for several hours after the time at which HSP70 synthesis had been turned off in control cells.	Quercetin	33-42	heat shock protein family A (Hsp70) member 4	Homo sapiens	144-149
8198534-9	1994	Under all conditions tested, the quercetin-induced block of HSP70 synthesis was found to be transient and, after an initial delay, synthesis of HSP70 reached the control rate and continued at the same level for several hours after the time at which HSP70 synthesis had been turned off in control cells.	Quercetin	33-42	heat shock protein family A (Hsp70) member 4	Homo sapiens	144-149
8198534-10	1994	Finally, inhibition of HSP70 synthesis by quercetin appeared to be dependent on the temperature used and on the type of stressor.	Quercetin	42-51	heat shock protein family A (Hsp70) member 4	Homo sapiens	23-28
8162591-0	1994	Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468.	Quercetin	0-9	tumor protein p53	Homo sapiens	49-52
8162591-4	1994	We have correlated these effects on cell proliferation with the observation that quercetin strongly inhibited, in a time- and dose-dependent fashion, the expression of the mutated p53 protein, which is the only form present at high levels in this cell line.	Quercetin	81-90	tumor protein p53	Homo sapiens	180-183
8162591-6	1994	Quercetin did not affect the steady-state mRNA levels of p53, but prevented the accumulation of newly synthesized p53 protein.	Quercetin	0-9	tumor protein p53	Homo sapiens	114-117
8162591-7	1994	This quercetin action appeared to be somewhat specific for p53 because the drug did not alter the amount of other proteins present in MDA-MB468 cells such as P-glycoprotein and did not prevent the induction of the synthesis of epidermal growth factor receptor in response to epidermal growth factor.	Quercetin	5-14	tumor protein p53	Homo sapiens	59-62
8203931-1	1994	The mutagenicity of quercetin, a flavonoid, was examined by means of DNA fingerprint analysis using the Pc-1 and Pc-2 minisatellite probes that efficiently detect mutations due to recombination.	Quercetin	20-29	chromobox 4	Homo sapiens	113-117
8157359-0	1994	Quercetin enhances transforming growth factor beta 1 secretion by human ovarian cancer cells.	Quercetin	0-9	transforming growth factor beta 1	Homo sapiens	19-52
8157359-1	1994	Our study demonstrates that quercetin (Q)-induced growth-inhibitory activity in ovarian cancer cells may be mediated by modulation of transforming growth factor beta 1 (TGF beta 1) production.	Quercetin	39-40	transforming growth factor beta 1	Homo sapiens	169-179
8157359-1	1994	Our study demonstrates that quercetin (Q)-induced growth-inhibitory activity in ovarian cancer cells may be mediated by modulation of transforming growth factor beta 1 (TGF beta 1) production.	Quercetin	28-37	transforming growth factor beta 1	Homo sapiens	134-167
8157359-1	1994	Our study demonstrates that quercetin (Q)-induced growth-inhibitory activity in ovarian cancer cells may be mediated by modulation of transforming growth factor beta 1 (TGF beta 1) production.	Quercetin	28-37	transforming growth factor beta 1	Homo sapiens	169-179
8157359-1	1994	Our study demonstrates that quercetin (Q)-induced growth-inhibitory activity in ovarian cancer cells may be mediated by modulation of transforming growth factor beta 1 (TGF beta 1) production.	Quercetin	39-40	transforming growth factor beta 1	Homo sapiens	134-167
7923555-0	1994	Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	109-123
7923555-3	1994	Since ADR resistance in these cells is associated with the expression of high levels of P-glycoprotein (Pgp), we evaluated the effect of Q and related flavonoids of Pgp activity in cytofluorographic efflux experiments with the fluorescent dye rhodamine 123 (Rh 123).	Quercetin	137-138	ATP binding cassette subfamily B member 1	Homo sapiens	165-168
7923555-4	1994	Our results indicate that Q and 3-OMe Q (3",4",7-trimethoxyquercetin) but not the 3-rhamnosylglucoside of Q (rutin) inhibit the Pgp pump-efflux activity in a dose-related manner.	Quercetin	26-27	ATP binding cassette subfamily B member 1	Homo sapiens	128-131
7506028-0	1993	Quercetin-induced expression of rat mast cell protease II and accumulation of secretory granules in rat basophilic leukemia cells.	Quercetin	0-9	mast cell protease 2	Rattus norvegicus	36-57
7903198-4	1993	In our attempt to find naturally occurring dietary compounds which may stimulate the P-gp-mediated efflux of carcinogens, we found that certain flavonols, kaempferol, quercetin, and galangin, are potent stimulators of the P-gp-mediated efflux of 7,12-dimethylbenz(a)-anthracene.	Quercetin	167-176	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
7903198-4	1993	In our attempt to find naturally occurring dietary compounds which may stimulate the P-gp-mediated efflux of carcinogens, we found that certain flavonols, kaempferol, quercetin, and galangin, are potent stimulators of the P-gp-mediated efflux of 7,12-dimethylbenz(a)-anthracene.	Quercetin	167-176	ATP binding cassette subfamily B member 1	Homo sapiens	222-226
7506028-3	1993	Here we show that the flavonoid quercetin, which inhibits mast cell secretion of histamine, also inhibited RBL cell proliferation and constitutive histamine release while it induced synthesis of rat mast cell protease (RMCP) II and triggered processes leading to accumulation of secretory granules.	Quercetin	32-41	mast cell protease 2	Rattus norvegicus	204-227
7506028-5	1993	Quercetin did not affect the expression of mRNA for alpha-subunit of immunoglobulin E (IgE) receptor, but led to increased expression of mRNA for, and synthesis of RMCP II, which is a marker protein for MMC.	Quercetin	0-9	mast cell protease 2	Rattus norvegicus	164-171
8225564-2	1993	Quercetin and chlorpromazine were found to inhibit PLA2 activity in lower concentrations (&lt; 100 microM), while aristolochic acid and indomethacin were inhibitory only in higher concentrations (&gt; 100 microM).	Quercetin	0-9	phospholipase A2 group IIA	Homo sapiens	51-55
8279819-0	1993	Quercetin potentiates TNF-induced antiviral activity.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	22-25
8279819-2	1993	The antiviral activity of TNF against VSV and EMCV is greatly enhanced by combination with quercetin.	Quercetin	91-100	tumor necrosis factor	Homo sapiens	26-29
8279819-3	1993	Induction of 2",5"-oligo-adenylate (2-5A) synthetase by TNF is also enhanced by quercetin.	Quercetin	80-89	tumor necrosis factor	Homo sapiens	56-59
8491500-9	1993	EGF action has also been coupled to the stimulation of tyrosine kinase activity; therefore, we examined the effects of the tyrosine kinase inhibitors genistein and quercetin.	Quercetin	164-173	epidermal growth factor like 1	Rattus norvegicus	0-3
8367538-5	1993	This effect was qualitatively similar to that induced by NaF, suggesting that quercetin may, like NaF, also inhibit type I photooxidations, which contribute to hemolysis.	Quercetin	78-87	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
8225564-3	1993	The order of potency against Vipera PLA2 was: quercetin &gt; chlorpromazine &gt; aristolochic acid &gt; indomethacin, while the order of potency against pancreatic PLA2 was: chlorpromazine &gt; aristolochic acid &gt; indomethacin &gt;&gt; quercetin.	Quercetin	46-55	phospholipase A2 group IIA	Homo sapiens	36-40
8225564-4	1993	Thus, quercetin was a potent inhibitor towards group II PLA2 (IC50 = 2 microM), but a very weak inhibitor against group I PLA2, with maximum 30% inhibition.	Quercetin	6-15	phospholipase A2 group IIA	Homo sapiens	56-60
8225564-4	1993	Thus, quercetin was a potent inhibitor towards group II PLA2 (IC50 = 2 microM), but a very weak inhibitor against group I PLA2, with maximum 30% inhibition.	Quercetin	6-15	phospholipase A2 group IIA	Homo sapiens	122-126
8225564-7	1993	Together, these results indicate that (1) different PLA2 inhibitors have different potency depending on which type of PLA2 they are used against, (2) quercetin selectively inhibits group II PLA2 and may therefore be used to discriminate between different PLA2 forms in biological materials, and (3) both PLA2 of group I and group II are present in septic shock plasma.	Quercetin	150-159	phospholipase A2 group IIA	Homo sapiens	52-56
8225564-7	1993	Together, these results indicate that (1) different PLA2 inhibitors have different potency depending on which type of PLA2 they are used against, (2) quercetin selectively inhibits group II PLA2 and may therefore be used to discriminate between different PLA2 forms in biological materials, and (3) both PLA2 of group I and group II are present in septic shock plasma.	Quercetin	150-159	phospholipase A2 group IIA	Homo sapiens	118-122
8225564-7	1993	Together, these results indicate that (1) different PLA2 inhibitors have different potency depending on which type of PLA2 they are used against, (2) quercetin selectively inhibits group II PLA2 and may therefore be used to discriminate between different PLA2 forms in biological materials, and (3) both PLA2 of group I and group II are present in septic shock plasma.	Quercetin	150-159	phospholipase A2 group IIA	Homo sapiens	118-122
8225564-7	1993	Together, these results indicate that (1) different PLA2 inhibitors have different potency depending on which type of PLA2 they are used against, (2) quercetin selectively inhibits group II PLA2 and may therefore be used to discriminate between different PLA2 forms in biological materials, and (3) both PLA2 of group I and group II are present in septic shock plasma.	Quercetin	150-159	phospholipase A2 group IIA	Homo sapiens	118-122
8225564-7	1993	Together, these results indicate that (1) different PLA2 inhibitors have different potency depending on which type of PLA2 they are used against, (2) quercetin selectively inhibits group II PLA2 and may therefore be used to discriminate between different PLA2 forms in biological materials, and (3) both PLA2 of group I and group II are present in septic shock plasma.	Quercetin	150-159	phospholipase A2 group IIA	Homo sapiens	118-122
8347809-6	1993	The neuronal density of the CA1 hippocampus in animals subjected to treatment with quercetin and anti-HSP70 antibody was significantly lower than vehicle-treated animals but were significantly higher than animals with a single 3 min period of ischaemia.	Quercetin	83-92	carbonic anhydrase 1	Homo sapiens	28-31
8491500-10	1993	Both genistein (10(-5) M) and quercetin (10(-5) M) abolished the inhibition of renin by EGF (control, 100 +/- 3%; EGF, 82 +/- 4%; EGF plus genistein, 110 +/- 7%; p &lt; 0.01; EGF, 75 +/- 4%; EGF plus quercetin, 92 +/- 4%; p &lt; 0.01).	Quercetin	30-39	renin	Rattus norvegicus	79-84
8491500-10	1993	Both genistein (10(-5) M) and quercetin (10(-5) M) abolished the inhibition of renin by EGF (control, 100 +/- 3%; EGF, 82 +/- 4%; EGF plus genistein, 110 +/- 7%; p &lt; 0.01; EGF, 75 +/- 4%; EGF plus quercetin, 92 +/- 4%; p &lt; 0.01).	Quercetin	30-39	epidermal growth factor like 1	Rattus norvegicus	88-91
8491500-10	1993	Both genistein (10(-5) M) and quercetin (10(-5) M) abolished the inhibition of renin by EGF (control, 100 +/- 3%; EGF, 82 +/- 4%; EGF plus genistein, 110 +/- 7%; p &lt; 0.01; EGF, 75 +/- 4%; EGF plus quercetin, 92 +/- 4%; p &lt; 0.01).	Quercetin	30-39	epidermal growth factor like 1	Rattus norvegicus	114-117
8491500-10	1993	Both genistein (10(-5) M) and quercetin (10(-5) M) abolished the inhibition of renin by EGF (control, 100 +/- 3%; EGF, 82 +/- 4%; EGF plus genistein, 110 +/- 7%; p &lt; 0.01; EGF, 75 +/- 4%; EGF plus quercetin, 92 +/- 4%; p &lt; 0.01).	Quercetin	30-39	epidermal growth factor like 1	Rattus norvegicus	114-117
8491500-10	1993	Both genistein (10(-5) M) and quercetin (10(-5) M) abolished the inhibition of renin by EGF (control, 100 +/- 3%; EGF, 82 +/- 4%; EGF plus genistein, 110 +/- 7%; p &lt; 0.01; EGF, 75 +/- 4%; EGF plus quercetin, 92 +/- 4%; p &lt; 0.01).	Quercetin	30-39	epidermal growth factor like 1	Rattus norvegicus	114-117
8491500-10	1993	Both genistein (10(-5) M) and quercetin (10(-5) M) abolished the inhibition of renin by EGF (control, 100 +/- 3%; EGF, 82 +/- 4%; EGF plus genistein, 110 +/- 7%; p &lt; 0.01; EGF, 75 +/- 4%; EGF plus quercetin, 92 +/- 4%; p &lt; 0.01).	Quercetin	30-39	epidermal growth factor like 1	Rattus norvegicus	114-117
8491500-10	1993	Both genistein (10(-5) M) and quercetin (10(-5) M) abolished the inhibition of renin by EGF (control, 100 +/- 3%; EGF, 82 +/- 4%; EGF plus genistein, 110 +/- 7%; p &lt; 0.01; EGF, 75 +/- 4%; EGF plus quercetin, 92 +/- 4%; p &lt; 0.01).	Quercetin	200-209	renin	Rattus norvegicus	79-84
8260877-7	1993	In contrast, quercetine, a selective inhibitor of the protein kinase M (PKM) did not inhibit during the first minutes but inhibited efficiently during later phases of incubation.	Quercetin	13-23	pyruvate kinase M1/2	Homo sapiens	54-70
8352018-2	1993	The results showed that TPA (1-100 ng.ml-1) and lipopolysaccharides (LPS) (1-100 ng.ml-1) induced the release of TNF from PA-primed mouse peritoneal macrophages in dose- and time-dependent manners in vitro, and the effects of TPA and LPS were inhibited by H-7 (12.5-100 mumol.L-1) or quercetin (6.25-25 mumol.L-1) in a dose-dependent manner.	Quercetin	284-293	tumor necrosis factor	Mus musculus	113-116
8260877-7	1993	In contrast, quercetine, a selective inhibitor of the protein kinase M (PKM) did not inhibit during the first minutes but inhibited efficiently during later phases of incubation.	Quercetin	13-23	pyruvate kinase M1/2	Homo sapiens	72-75
1286139-1	1992	Quercetin inhibited aggregation of porcine blood platelets induced by collagen (IC50 = 0.2 mM), ADP (IC50 = 0.5 mM), thrombin (IC50 = 0.02 mM) and ionophore A23187 (IC50 = 1.5 mM).	Quercetin	0-9	coagulation factor II, thrombin	Homo sapiens	117-125
1423313-3	1992	Expression of the growth-related genes histone H4, cyclin A and B, and p34cdc2 was suppressed in cells blocked with quercetin.	Quercetin	116-125	H4 clustered histone 2	Homo sapiens	39-49
1423313-3	1992	Expression of the growth-related genes histone H4, cyclin A and B, and p34cdc2 was suppressed in cells blocked with quercetin.	Quercetin	116-125	cyclin A2	Homo sapiens	51-65
1423313-3	1992	Expression of the growth-related genes histone H4, cyclin A and B, and p34cdc2 was suppressed in cells blocked with quercetin.	Quercetin	116-125	cyclin dependent kinase 1	Homo sapiens	71-78
1324726-0	1992	Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes.	Quercetin	0-9	insulin receptor	Rattus norvegicus	31-47
1324726-1	1992	We report here that quercetin, a naturally occurring bioflavonoid, is an effective blocker of insulin receptor tyrosine kinase-catalyzed phosphorylation of exogenous substrate.	Quercetin	20-29	insulin receptor	Mus musculus	94-110
21584546-1	1992	Quercetin (from 0.1 muM to 10 muM) produced a dose dependent inhibition of colony formation of cells from 4 primary ovarian tumors expressing type II estrogen binding sites (type II EBS).The combined effects of quercetin ( 10 muM) and hyperthermia (42-degrees-C) result in a significant synergistic action on three out of four tumors analyzed.	Quercetin	0-9	latexin	Homo sapiens	20-23
21584546-1	1992	Quercetin (from 0.1 muM to 10 muM) produced a dose dependent inhibition of colony formation of cells from 4 primary ovarian tumors expressing type II estrogen binding sites (type II EBS).The combined effects of quercetin ( 10 muM) and hyperthermia (42-degrees-C) result in a significant synergistic action on three out of four tumors analyzed.	Quercetin	0-9	latexin	Homo sapiens	30-33
21584546-1	1992	Quercetin (from 0.1 muM to 10 muM) produced a dose dependent inhibition of colony formation of cells from 4 primary ovarian tumors expressing type II estrogen binding sites (type II EBS).The combined effects of quercetin ( 10 muM) and hyperthermia (42-degrees-C) result in a significant synergistic action on three out of four tumors analyzed.	Quercetin	0-9	latexin	Homo sapiens	30-33
1321338-4	1992	In this study, we examined the effects of quercetin on the induction of HSP70 promoter-regulated chloramphenicol acetyltransferase (CAT) activity and on the binding of HSF to the heat shock element (HSE) by a gel mobility shift assay with extracts of COLO 320DM cells.	Quercetin	42-51	heat shock protein family A (Hsp70) member 4	Homo sapiens	72-77
1321338-5	1992	Quercetin inhibited heat-induced CAT activity in COS-7 and COLO 320DM cells which were transfected with plasmids bearing the CAT gene under the control of the promoter region of the human HSP70 gene.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	188-193
1321338-6	1992	Treatment with quercetin inhibited the binding of HSF to the HSE in whole-cell extracts activated in vivo by heat shock and in cytoplasmic extracts activated in vitro by elevated temperature or by urea.	Quercetin	15-24	interleukin 6	Homo sapiens	50-53
1321338-8	1992	The formation of the HSF-HSE complex was not inhibited when quercetin was added only during the binding reaction of HSF to the HSE after in vitro heat activation.	Quercetin	60-69	interleukin 6	Homo sapiens	21-24
1321338-8	1992	The formation of the HSF-HSE complex was not inhibited when quercetin was added only during the binding reaction of HSF to the HSE after in vitro heat activation.	Quercetin	60-69	interleukin 6	Homo sapiens	116-119
1321338-9	1992	Quercetin thus interacts with HSF and inhibits the induction of HSPs after heat shock through inhibition of HSF activation.	Quercetin	0-9	interleukin 6	Homo sapiens	30-33
1321338-9	1992	Quercetin thus interacts with HSF and inhibits the induction of HSPs after heat shock through inhibition of HSF activation.	Quercetin	0-9	interleukin 6	Homo sapiens	108-111
1497645-4	1992	Furthermore, a combination of low pH and quercetin treatment distinctively altered the expression of HSP70 gene compared with that of HSP28 or HSP90 gene.	Quercetin	41-50	heat shock protein family B (small) member 1	Homo sapiens	134-139
1497645-4	1992	Furthermore, a combination of low pH and quercetin treatment distinctively altered the expression of HSP70 gene compared with that of HSP28 or HSP90 gene.	Quercetin	41-50	heat shock protein 90 alpha family class A member 1	Homo sapiens	143-148
1349537-0	1992	Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite.	Quercetin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
1349537-3	1992	We have identified the effects of quercetin on the MDR1 gene expression in the human hepatocarcinoma cells line, HepG2.	Quercetin	34-43	ATP binding cassette subfamily B member 1	Homo sapiens	51-55
1349537-4	1992	The increase of P-glycoprotein synthesis and MDR1 mRNA accumulation caused by exposure to arsenite were inhibited by quercetin.	Quercetin	117-126	ATP binding cassette subfamily B member 1	Homo sapiens	16-30
1349537-4	1992	The increase of P-glycoprotein synthesis and MDR1 mRNA accumulation caused by exposure to arsenite were inhibited by quercetin.	Quercetin	117-126	ATP binding cassette subfamily B member 1	Homo sapiens	45-49
1349537-5	1992	The CAT assay suggested that quercetin suppressed the transcriptional activation of the MDR1 gene after exposure to arsenite.	Quercetin	29-38	ATP binding cassette subfamily B member 1	Homo sapiens	88-92
1497645-4	1992	Furthermore, a combination of low pH and quercetin treatment distinctively altered the expression of HSP70 gene compared with that of HSP28 or HSP90 gene.	Quercetin	41-50	heat shock protein family A (Hsp70) member 4	Homo sapiens	101-106
1286139-2	1992	Preincubation of platelets with 10 mM LiCl abolished the inhibitory effect of quercetin on the aggregation of these cells induced by thrombin.	Quercetin	78-87	coagulation factor II, thrombin	Homo sapiens	133-141
1772777-8	1991	When normal bone marrow were deprived in CD34+ haematopoietic progenitors the resultant population became highly sensitive to quercetin, with a mean recovery of BFU-E and CFU-GM of 5% and 12% of controls respectively in the presence of 2 x 10(-5) M quercetin.	Quercetin	126-135	CD34 molecule	Homo sapiens	41-45
1772777-9	1991	Furthermore, CD34 progenitors, positively selected, appeared fully resistant to quercetin concentrations as high as 2 x 10(-5) M. Thus, CD34+ progenitors are a quercetin-resistant component in normal bone marrow.	Quercetin	80-89	CD34 molecule	Homo sapiens	13-17
1772777-9	1991	Furthermore, CD34 progenitors, positively selected, appeared fully resistant to quercetin concentrations as high as 2 x 10(-5) M. Thus, CD34+ progenitors are a quercetin-resistant component in normal bone marrow.	Quercetin	80-89	CD34 molecule	Homo sapiens	136-140
1772777-9	1991	Furthermore, CD34 progenitors, positively selected, appeared fully resistant to quercetin concentrations as high as 2 x 10(-5) M. Thus, CD34+ progenitors are a quercetin-resistant component in normal bone marrow.	Quercetin	160-169	CD34 molecule	Homo sapiens	13-17
1756517-3	1991	Catalase significantly decreased quercetin-induced nuclear DNA damage only in the presence of iron and had no significant effect on lipid peroxidation.	Quercetin	33-42	catalase	Rattus norvegicus	0-8
1772777-9	1991	Furthermore, CD34 progenitors, positively selected, appeared fully resistant to quercetin concentrations as high as 2 x 10(-5) M. Thus, CD34+ progenitors are a quercetin-resistant component in normal bone marrow.	Quercetin	160-169	CD34 molecule	Homo sapiens	136-140
2085852-4	1990	Quercetin inhibited the induction of hsp70 at the level of mRNA accumulation.	Quercetin	0-9	heat shock protein family A (Hsp70) member 4	Homo sapiens	37-42
1955374-3	1991	Mutagenicity of quercetin was examined by means of DNA fingerprint analysis using the Pc-1 probe that efficiently detects mutations due to recombination.	Quercetin	16-25	minisatellite 6 hypermutable	Mus musculus	86-90
1879042-0	1991	Quercetin inhibits the growth of a multidrug-resistant estrogen-receptor-negative MCF-7 human breast-cancer cell line expressing type II estrogen-binding sites.	Quercetin	0-9	estrogen receptor 1	Homo sapiens	55-72
2363268-0	1990	[A simple and sensitive method of determination of superoxide dismutase activity based on the reaction of quercetin oxidation].	Quercetin	106-115	superoxide dismutase 1	Homo sapiens	51-71
2111975-3	1990	The addition of 5-lipoxygenase inhibitors (AA 861, NDGA and quercetin) showed a growth-stimulative effect.	Quercetin	60-69	arachidonate 5-lipoxygenase	Mus musculus	16-30
2363268-1	1990	An indirect method for determination of superoxide dismutase (SOD) activity, based on inhibition of quercetin autooxidation, was developed.	Quercetin	100-109	superoxide dismutase 1	Homo sapiens	40-60
2363268-1	1990	An indirect method for determination of superoxide dismutase (SOD) activity, based on inhibition of quercetin autooxidation, was developed.	Quercetin	100-109	superoxide dismutase 1	Homo sapiens	62-65
2110088-2	1990	The effects of nafazatrom, nordihydroguaiaretic acid (NDGA) and quercetin on Ca2(+)-induced vasoconstriction were studied in isolated rabbit ear arteries.	Quercetin	64-73	carbonic anhydrase 2	Oryctolagus cuniculus	77-80
2110088-13	1990	The inhibitory effects of nafazatrom and quercetin were antagonized by Ca2+ (2.5 mM) or Bay K 8644 (1 microM), a calcium channel activator.	Quercetin	41-50	carbonic anhydrase 2	Oryctolagus cuniculus	71-74
33940289-5	2021	In silico analysis pointed out rutinoside derivatives of cyanidin and quercetin as the most potent inhibitors of alpha-Gls, alpha-Amy and hDPP III enzymes.	Quercetin	70-79	dipeptidyl peptidase 3	Homo sapiens	138-146
33770716-9	2021	Our results shown that the ectopic PAP1 expression led to significant accumulation of cyanidin-type anthocyanins, quercetin-type flavonols and hydroxycinnamic acids and their glycosylated derivatives.	Quercetin	114-123	phosphatidic acid phosphatase 1	Arabidopsis thaliana	35-39
33798596-9	2021	Besides, the expression levels of AMPK and SIRT-1 in ovarian tissue were upregulated in the rats which received quercetin.	Quercetin	112-121	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	34-38
33798596-9	2021	Besides, the expression levels of AMPK and SIRT-1 in ovarian tissue were upregulated in the rats which received quercetin.	Quercetin	112-121	sirtuin 1	Rattus norvegicus	43-49
33798596-10	2021	Quercetin also reversed the PCOS-induced alteration in adipose tissue levels of adiponectin, visfatin, and resistin.	Quercetin	0-9	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	80-91
33798596-10	2021	Quercetin also reversed the PCOS-induced alteration in adipose tissue levels of adiponectin, visfatin, and resistin.	Quercetin	0-9	nicotinamide phosphoribosyltransferase	Rattus norvegicus	93-101
33767763-0	2021	Quercetin suppresses apoptosis of chondrocytes induced by IL-1beta via inactivation of p38 MAPK signaling pathway.	Quercetin	0-9	interleukin 1 alpha	Homo sapiens	58-66
33939881-0	2021	Quercetin Attenuates Atherosclerotic Inflammation by Inhibiting Gal-3-NLRP3 Signaling Pathway.	Quercetin	0-9	lectin, galactose binding, soluble 3	Mus musculus	64-69
33939881-0	2021	Quercetin Attenuates Atherosclerotic Inflammation by Inhibiting Gal-3-NLRP3 Signaling Pathway.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	70-75
33939881-2	2021	Herein, we investigated the anti-arteriosclerotic properties of quercetin by modulating galectin-3 (Gal-3)-NLR family, pyrin domain-containing 3 (NLRP3) pathway.	Quercetin	64-73	lectin, galactose binding, soluble 3	Mus musculus	88-98
33939881-2	2021	Herein, we investigated the anti-arteriosclerotic properties of quercetin by modulating galectin-3 (Gal-3)-NLR family, pyrin domain-containing 3 (NLRP3) pathway.	Quercetin	64-73	NLR family, pyrin domain containing 3	Mus musculus	146-151
33939881-5	2021	Proteomic technology identified Gal-3 was increased by HFD but lowered by quercetin.	Quercetin	74-83	galectin 3	Homo sapiens	32-37
33939881-6	2021	Furthermore, immunofluorescence and immunohistochemistry exhibited higher expressions of Gal-3 and NLRP3 in carotid plaques and plaques from HFD-fed mice, which were concurrently downregulated by quercetin.	Quercetin	196-205	lectin, galactose binding, soluble 3	Mus musculus	89-94
33939881-6	2021	Furthermore, immunofluorescence and immunohistochemistry exhibited higher expressions of Gal-3 and NLRP3 in carotid plaques and plaques from HFD-fed mice, which were concurrently downregulated by quercetin.	Quercetin	196-205	NLR family, pyrin domain containing 3	Mus musculus	99-104
33939881-7	2021	Similar to TD139, quercetin dramatically suppressed NLRP3 inflammasome activation in ox-LDL-laden macrophages, and accordingly alleviated cellular steatosis and IL-1beta secretion, which was abolished by recombinant Gal-3.	Quercetin	18-27	NLR family, pyrin domain containing 3	Mus musculus	52-57
33939881-7	2021	Similar to TD139, quercetin dramatically suppressed NLRP3 inflammasome activation in ox-LDL-laden macrophages, and accordingly alleviated cellular steatosis and IL-1beta secretion, which was abolished by recombinant Gal-3.	Quercetin	18-27	interleukin 1 alpha	Mus musculus	161-169
33939881-7	2021	Similar to TD139, quercetin dramatically suppressed NLRP3 inflammasome activation in ox-LDL-laden macrophages, and accordingly alleviated cellular steatosis and IL-1beta secretion, which was abolished by recombinant Gal-3.	Quercetin	18-27	lectin, galactose binding, soluble 3	Mus musculus	216-221
33939881-9	2021	CONCLUSION: Gal-3 initiates inflammatory lesions by activating NLRP3 inflammasome which functions as a candidate target of quercetin exerting favorable anti-atherogenic effects.	Quercetin	123-132	lectin, galactose binding, soluble 3	Mus musculus	12-17
33939881-9	2021	CONCLUSION: Gal-3 initiates inflammatory lesions by activating NLRP3 inflammasome which functions as a candidate target of quercetin exerting favorable anti-atherogenic effects.	Quercetin	123-132	NLR family, pyrin domain containing 3	Mus musculus	63-68
33767763-1	2021	The objective of the present study was to investigate the effect of quercetin and evaluate its protective effect on articular cartilage in patients with osteoarthritis (OA), by intervening the p38 pathway.	Quercetin	68-77	mitogen-activated protein kinase 14	Homo sapiens	193-196
33767763-5	2021	It was found that quercetin, at the concentration of 100 umol/l, can decrease inflammatory factors relevant to OA, inhibit the expression of p38, matrix metalloprotease 13 and ADAMTS in the pathway, and promote the expression of collagen II.	Quercetin	18-27	mitogen-activated protein kinase 14	Homo sapiens	141-144
33803419-0	2021	Dual Anti-Malarial and GSK3beta-Mediated Cytokine-Modulating Activities of Quercetin Are Requisite of Its Potential as a Plant-Derived Therapeutic in Malaria.	Quercetin	75-84	glycogen synthase kinase 3 alpha	Mus musculus	23-31
33811899-0	2021	Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity.	Quercetin	18-27	Kelch-like ECH-associated protein 1	Rattus norvegicus	65-70
33811899-0	2021	Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity.	Quercetin	18-27	NFE2 like bZIP transcription factor 2	Rattus norvegicus	71-75
33811899-0	2021	Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity.	Quercetin	18-27	heme oxygenase 1	Rattus norvegicus	76-92
33811899-2	2021	We investigated the effect of chlorogenic acid (CGA), quercetin (Qt), coenzyme Q10 (Q10) and silymarin on the expression of Keap1/Nrf2 complex and its downstream target; heme oxygenase 1 (HO-1) as well as inflammation and apoptosis in an acute liver toxicity model induced by thioacetamide (TAA).	Quercetin	54-63	Kelch-like ECH-associated protein 1	Rattus norvegicus	124-129
33811899-2	2021	We investigated the effect of chlorogenic acid (CGA), quercetin (Qt), coenzyme Q10 (Q10) and silymarin on the expression of Keap1/Nrf2 complex and its downstream target; heme oxygenase 1 (HO-1) as well as inflammation and apoptosis in an acute liver toxicity model induced by thioacetamide (TAA).	Quercetin	54-63	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-134
33811899-2	2021	We investigated the effect of chlorogenic acid (CGA), quercetin (Qt), coenzyme Q10 (Q10) and silymarin on the expression of Keap1/Nrf2 complex and its downstream target; heme oxygenase 1 (HO-1) as well as inflammation and apoptosis in an acute liver toxicity model induced by thioacetamide (TAA).	Quercetin	54-63	heme oxygenase 1	Rattus norvegicus	170-186
33763365-16	2021	For ingredient quercetin, the targets were AKR1B1 and VCAM1.	Quercetin	15-24	aldo-keto reductase family 1 member B	Homo sapiens	43-49
33763365-16	2021	For ingredient quercetin, the targets were AKR1B1 and VCAM1.	Quercetin	15-24	vascular cell adhesion molecule 1	Homo sapiens	54-59
33803419-3	2021	Quercetin (3,3",4",5,7-pentahydroxyflavone) is known to inhibit glycogen synthase kinase-3beta (GSK3beta), a potent regulator of both pro- and anti-inflammatory effects.	Quercetin	0-9	glycogen synthase kinase 3 beta	Mus musculus	64-94
33803419-3	2021	Quercetin (3,3",4",5,7-pentahydroxyflavone) is known to inhibit glycogen synthase kinase-3beta (GSK3beta), a potent regulator of both pro- and anti-inflammatory effects.	Quercetin	0-9	glycogen synthase kinase 3 alpha	Mus musculus	96-104
33803419-3	2021	Quercetin (3,3",4",5,7-pentahydroxyflavone) is known to inhibit glycogen synthase kinase-3beta (GSK3beta), a potent regulator of both pro- and anti-inflammatory effects.	Quercetin	11-42	glycogen synthase kinase 3 beta	Mus musculus	64-94
33803419-3	2021	Quercetin (3,3",4",5,7-pentahydroxyflavone) is known to inhibit glycogen synthase kinase-3beta (GSK3beta), a potent regulator of both pro- and anti-inflammatory effects.	Quercetin	11-42	glycogen synthase kinase 3 alpha	Mus musculus	96-104
33803419-6	2021	Western blotting and analysis of cytokines were carried out to determine the GSK3beta-mediated cytokine-modulating effects of quercetin in infected animals.	Quercetin	126-135	glycogen synthase kinase 3 alpha	Mus musculus	77-85
33803419-10	2021	Quercetin is a potential plant-derived therapeutic for malaria on the basis that it can elicit anti-malarial and GSK3beta-mediated cytokine-modulating effects.	Quercetin	0-9	glycogen synthase kinase 3 alpha	Mus musculus	113-121
32890553-2	2020	Herein, we attempted to simultaneously inhibit the growth and lung metastasis of breast cancer by delivering quercetin (QU) using LyP-1-functionalized regenerated silk fibroin-based nanoparticles (NPs).	Quercetin	109-118	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	130-135
29379801-0	2017	Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	81-84
33237147-0	2020	Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression.	Quercetin	44-53	matrix metallopeptidase 2	Homo sapiens	115-122
33237147-7	2020	In this study, the combination of quercetin and lonidamine has been evaluated for the first time and the combination treatment decreased MMP-2/-9 mRNA expression more potently than the effects of the compounds alone.	Quercetin	34-43	matrix metallopeptidase 2	Homo sapiens	137-145
27813122-7	2017	Evidence for the downstream TopoII-independent mutagenic potential of Que was obtained by documenting further increased frequencies of MLL rearrangements in human HSPCs concomitantly treated with Etoposide and Que versus single treatments.	Quercetin	70-73	lysine methyltransferase 2A	Homo sapiens	135-138
29379801-0	2017	Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	99-104
29379801-12	2017	These results suggested that the beneficial effects of quercetin on glucose and lipid metabolism disorder are probably associated with the upregulated activity and protein level of SIRT1 and its influence on Akt signaling pathway.	Quercetin	55-64	sirtuin 1	Rattus norvegicus	181-186
29379801-12	2017	These results suggested that the beneficial effects of quercetin on glucose and lipid metabolism disorder are probably associated with the upregulated activity and protein level of SIRT1 and its influence on Akt signaling pathway.	Quercetin	55-64	AKT serine/threonine kinase 1	Rattus norvegicus	208-211
26670180-5	2016	Quercetin also causes a decrease in the serum levels of YKL-40 and periostin in the oxidative lung injury induced by the experimental sepsis model.	Quercetin	0-9	periostin	Rattus norvegicus	67-76
23902346-2	2013	The objective of this study was to investigate whether the natural flavonoid quercetin can inhibit matrix metalloproteinase (MMP)-2 and -9 activities through the attenuation of reactive oxygen species (ROS) formation, an event expected to lead to the inhibition of cell motility.	Quercetin	77-86	matrix metallopeptidase 2	Homo sapiens	99-138
23902346-6	2013	We also found that quercetin, up to 10 mug/mL, attenuated PMS-induced MMP-2 activation.	Quercetin	19-28	matrix metallopeptidase 2	Homo sapiens	70-75
24751879-4	2014	Moreover, treatment with both agents caused an increase in the levels of beta-catenin and their translocation to nuclei while quercetin, an inhibitor of Wnt/beta-catenin signaling, completely blocked the effects of LiCl on proliferation.	Quercetin	126-135	catenin (cadherin associated protein), beta 1	Mus musculus	157-169
16386736-0	2006	Bi-directional regulation of emodin and quercetin on smooth muscle myosin of gizzard.	Quercetin	40-49	myosin heavy chain 14	Homo sapiens	67-73
23902346-7	2013	We then investigated whether the decreased levels of MMP-2 activation could be attributable to lower levels of ROS formation by quercetin.	Quercetin	128-137	matrix metallopeptidase 2	Homo sapiens	53-58
23902346-8	2013	We found that quercetin treatments significantly attenuated PMS-induced ROS formation (P &lt; 0.01) and resulted in decreased cell motility associated with a reduction in MMP-2 and -9 activitiy in HT1080 cells, even in the absence of PMS treatment.	Quercetin	14-23	matrix metallopeptidase 2	Homo sapiens	171-183
20519418-11	2010	The findings that the antiinflammatory and antiapoptotic effects of CO were accompanied by activation of HSP-70, which in turn were reversed by quercetin, suggest that renoprotection by pretreatment with inhaled CO before CPB is mediated by activation of the renal heat shock response.	Quercetin	144-153	heat shock 70 kDa protein 6	Sus scrofa	105-111
16386736-1	2006	This study is to reveal the characteristics of bidirectional regulation of emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) and quercetin on gizzard smooth muscle myosin.	Quercetin	128-137	myosin heavy chain 14	Homo sapiens	163-169
34920080-10	2022	Quercetin, an HO-1 inducer, reduced syncytia formation and spike protein expression.	Quercetin	0-9	heme oxygenase 1	Homo sapiens	14-18
23196154-7	1995	The strongest effect was found with 5 and 10muM hispidulin, 0.05 muM quercetin, and 1 muM patuletin, increasing the IC(50) value of helenalin with circa 40%.	Quercetin	69-78	latexin	Homo sapiens	44-47
34920080-10	2022	Quercetin, an HO-1 inducer, reduced syncytia formation and spike protein expression.	Quercetin	0-9	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	59-64
34688696-0	2022	The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-kappaB and ROS/AMPK pathway.	Quercetin	25-34	toll like receptor 2	Homo sapiens	64-68
34688696-0	2022	The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-kappaB and ROS/AMPK pathway.	Quercetin	25-34	MYD88 innate immune signal transduction adaptor	Homo sapiens	69-74
34688696-0	2022	The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-kappaB and ROS/AMPK pathway.	Quercetin	25-34	nuclear factor kappa B subunit 1	Homo sapiens	75-84
34688696-10	2022	KEY FINDINGS: Our results showed that quercetin prevented THP-1 macrophage pyroptosis by reducing the expression of NLRP3 and cleaved-caspase1, as well as IL-1beta and N-GSDMD in a concentration dependent manner.	Quercetin	38-47	NLR family pyrin domain containing 3	Homo sapiens	116-121
34688696-0	2022	The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-kappaB and ROS/AMPK pathway.	Quercetin	25-34	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	93-97
34688696-10	2022	KEY FINDINGS: Our results showed that quercetin prevented THP-1 macrophage pyroptosis by reducing the expression of NLRP3 and cleaved-caspase1, as well as IL-1beta and N-GSDMD in a concentration dependent manner.	Quercetin	38-47	interleukin 1 alpha	Homo sapiens	155-163
34688696-11	2022	Quercetin suppressed NLRP3 inflammasome activation by inhibiting ROS overproduction.	Quercetin	0-9	NLR family pyrin domain containing 3	Homo sapiens	21-26
34688696-12	2022	Moreover, quercetin inhibited the phosphorylation of P65 and its translocation from cytoplasm into nuclear.	Quercetin	10-19	RELA proto-oncogene, NF-kB subunit	Homo sapiens	53-56
34688696-13	2022	In addition, we found that quercetin suppressed the increase of TLR2/Myd88 and p-AMPK induced by LPS/ATP, while both TLR2 and AMPK agonist weakened the inhibitory effect of quercetin on the activity of NLRP3 inflammasome and alleviated the protective effect on macrophages pyroptosis.	Quercetin	27-36	toll like receptor 2	Homo sapiens	64-68
34688696-13	2022	In addition, we found that quercetin suppressed the increase of TLR2/Myd88 and p-AMPK induced by LPS/ATP, while both TLR2 and AMPK agonist weakened the inhibitory effect of quercetin on the activity of NLRP3 inflammasome and alleviated the protective effect on macrophages pyroptosis.	Quercetin	27-36	MYD88 innate immune signal transduction adaptor	Homo sapiens	69-74
34688696-13	2022	In addition, we found that quercetin suppressed the increase of TLR2/Myd88 and p-AMPK induced by LPS/ATP, while both TLR2 and AMPK agonist weakened the inhibitory effect of quercetin on the activity of NLRP3 inflammasome and alleviated the protective effect on macrophages pyroptosis.	Quercetin	27-36	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	81-85
34688696-13	2022	In addition, we found that quercetin suppressed the increase of TLR2/Myd88 and p-AMPK induced by LPS/ATP, while both TLR2 and AMPK agonist weakened the inhibitory effect of quercetin on the activity of NLRP3 inflammasome and alleviated the protective effect on macrophages pyroptosis.	Quercetin	27-36	NLR family pyrin domain containing 3	Homo sapiens	202-207
34841658-0	2022	Effects of Quercetin on Ovarian Function and Regulation of the Ovarian PI3K/Akt/FoxO3a Signalling Pathway and Oxidative Stress in a Rat Model of Cyclophosphamide-Induced Premature Ovarian Failure.	Quercetin	11-20	AKT serine/threonine kinase 1	Rattus norvegicus	76-79
34688696-13	2022	In addition, we found that quercetin suppressed the increase of TLR2/Myd88 and p-AMPK induced by LPS/ATP, while both TLR2 and AMPK agonist weakened the inhibitory effect of quercetin on the activity of NLRP3 inflammasome and alleviated the protective effect on macrophages pyroptosis.	Quercetin	173-182	toll like receptor 2	Homo sapiens	117-121
34688696-13	2022	In addition, we found that quercetin suppressed the increase of TLR2/Myd88 and p-AMPK induced by LPS/ATP, while both TLR2 and AMPK agonist weakened the inhibitory effect of quercetin on the activity of NLRP3 inflammasome and alleviated the protective effect on macrophages pyroptosis.	Quercetin	173-182	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	126-130
34688696-13	2022	In addition, we found that quercetin suppressed the increase of TLR2/Myd88 and p-AMPK induced by LPS/ATP, while both TLR2 and AMPK agonist weakened the inhibitory effect of quercetin on the activity of NLRP3 inflammasome and alleviated the protective effect on macrophages pyroptosis.	Quercetin	173-182	NLR family pyrin domain containing 3	Homo sapiens	202-207
34688696-14	2022	SIGNIFICANCE: Quercetin possesses a protective effect on macrophages pyroptosis via TLR2/Myd88/NF-kappaB and ROS/AMPK pathway.	Quercetin	14-23	toll like receptor 2	Homo sapiens	84-88
34688696-14	2022	SIGNIFICANCE: Quercetin possesses a protective effect on macrophages pyroptosis via TLR2/Myd88/NF-kappaB and ROS/AMPK pathway.	Quercetin	14-23	MYD88 innate immune signal transduction adaptor	Homo sapiens	89-94
34688696-14	2022	SIGNIFICANCE: Quercetin possesses a protective effect on macrophages pyroptosis via TLR2/Myd88/NF-kappaB and ROS/AMPK pathway.	Quercetin	14-23	nuclear factor kappa B subunit 1	Homo sapiens	95-104
34688696-14	2022	SIGNIFICANCE: Quercetin possesses a protective effect on macrophages pyroptosis via TLR2/Myd88/NF-kappaB and ROS/AMPK pathway.	Quercetin	14-23	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	113-117
34841658-6	2022	Our results showed that quercetin could significantly increase the expression of AMH, E2, SOD, and GSH-Px, upregulate the protein expression of AMH, FSH, and its receptor, and decrease the expression ratio of phosphorylated PI3K, Akt, FOXO3a, and the unphosphorylated forms.	Quercetin	24-33	AKT serine/threonine kinase 1	Rattus norvegicus	230-233
34841658-0	2022	Effects of Quercetin on Ovarian Function and Regulation of the Ovarian PI3K/Akt/FoxO3a Signalling Pathway and Oxidative Stress in a Rat Model of Cyclophosphamide-Induced Premature Ovarian Failure.	Quercetin	11-20	forkhead box O3	Rattus norvegicus	80-86
34841658-6	2022	Our results showed that quercetin could significantly increase the expression of AMH, E2, SOD, and GSH-Px, upregulate the protein expression of AMH, FSH, and its receptor, and decrease the expression ratio of phosphorylated PI3K, Akt, FOXO3a, and the unphosphorylated forms.	Quercetin	24-33	forkhead box O3	Rattus norvegicus	235-241
34841658-7	2022	Moreover, quercetin inhibited the mRNA expression of PI3K, Akt, and FOXO3a.	Quercetin	10-19	AKT serine/threonine kinase 1	Rattus norvegicus	59-62
34841658-1	2022	To investigate the ability of quercetin to improve ovarian function and inhibit ovarian oxidative stress through the PI3K/Akt/FoxO3a signalling pathway in a rat model of premature ovarian failure (POF), we constructed a POF rat model with cyclophosphamide (CTX) and treated it with quercetin.	Quercetin	30-39	AKT serine/threonine kinase 1	Rattus norvegicus	122-125
34841658-7	2022	Moreover, quercetin inhibited the mRNA expression of PI3K, Akt, and FOXO3a.	Quercetin	10-19	forkhead box O3	Rattus norvegicus	68-74
34841658-1	2022	To investigate the ability of quercetin to improve ovarian function and inhibit ovarian oxidative stress through the PI3K/Akt/FoxO3a signalling pathway in a rat model of premature ovarian failure (POF), we constructed a POF rat model with cyclophosphamide (CTX) and treated it with quercetin.	Quercetin	30-39	forkhead box O3	Rattus norvegicus	126-132
34841658-8	2022	These results suggest that quercetin can restore ovarian function and inhibit oxidative stress by regulating the PI3K/Akt/FoxO3a signalling pathway.	Quercetin	27-36	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
34841658-8	2022	These results suggest that quercetin can restore ovarian function and inhibit oxidative stress by regulating the PI3K/Akt/FoxO3a signalling pathway.	Quercetin	27-36	forkhead box O3	Rattus norvegicus	122-128
34841658-6	2022	Our results showed that quercetin could significantly increase the expression of AMH, E2, SOD, and GSH-Px, upregulate the protein expression of AMH, FSH, and its receptor, and decrease the expression ratio of phosphorylated PI3K, Akt, FOXO3a, and the unphosphorylated forms.	Quercetin	24-33	anti-Mullerian hormone	Rattus norvegicus	81-84
34841658-6	2022	Our results showed that quercetin could significantly increase the expression of AMH, E2, SOD, and GSH-Px, upregulate the protein expression of AMH, FSH, and its receptor, and decrease the expression ratio of phosphorylated PI3K, Akt, FOXO3a, and the unphosphorylated forms.	Quercetin	24-33	anti-Mullerian hormone	Rattus norvegicus	144-147
34509603-16	2022	Further, in molecular docking analysis also, quercetin showed the strongest binding affinity towards DENV membrane receptor TIM-1 protein.	Quercetin	45-54	hepatitis A virus cellular receptor 1	Homo sapiens	124-129
34927513-0	2022	Quercetin attenuates lipopolysaccharide-mediated inflammatory injury in human nasal epithelial cells via regulating miR-21/DMBT1/NF-kappaB axis.	Quercetin	0-9	microRNA 21	Homo sapiens	116-122
34927513-0	2022	Quercetin attenuates lipopolysaccharide-mediated inflammatory injury in human nasal epithelial cells via regulating miR-21/DMBT1/NF-kappaB axis.	Quercetin	0-9	deleted in malignant brain tumors 1	Homo sapiens	123-128
34927513-0	2022	Quercetin attenuates lipopolysaccharide-mediated inflammatory injury in human nasal epithelial cells via regulating miR-21/DMBT1/NF-kappaB axis.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	129-138
34927513-2	2022	Our study aimed to explore the impacts of quercetin on lipopolysaccharide (LPS)-induced inflammatory injury and signal transduction of miR-21/DMBT1/NF-kappaB axis in human nasal epithelial cells (HNEpC).	Quercetin	42-51	microRNA 21	Homo sapiens	135-141
34927513-2	2022	Our study aimed to explore the impacts of quercetin on lipopolysaccharide (LPS)-induced inflammatory injury and signal transduction of miR-21/DMBT1/NF-kappaB axis in human nasal epithelial cells (HNEpC).	Quercetin	42-51	deleted in malignant brain tumors 1	Homo sapiens	142-147
34927513-2	2022	Our study aimed to explore the impacts of quercetin on lipopolysaccharide (LPS)-induced inflammatory injury and signal transduction of miR-21/DMBT1/NF-kappaB axis in human nasal epithelial cells (HNEpC).	Quercetin	42-51	nuclear factor kappa B subunit 1	Homo sapiens	148-157
34927513-9	2022	MiR-21 inhibition or DMBT1 over-expression weakened the protective effects of quercetin against LPS-induced inflammatory injury in HNEpC cells.	Quercetin	78-87	microRNA 21	Homo sapiens	0-6
34927513-9	2022	MiR-21 inhibition or DMBT1 over-expression weakened the protective effects of quercetin against LPS-induced inflammatory injury in HNEpC cells.	Quercetin	78-87	deleted in malignant brain tumors 1	Homo sapiens	21-26
34927513-10	2022	CONCLUSIONS: Quercetin could protect HNEpC cells against LPS-induced inflammatory injury via inducing miR-21/DMBT1/NF-kappaB axis.	Quercetin	13-22	microRNA 21	Homo sapiens	102-108
34927513-10	2022	CONCLUSIONS: Quercetin could protect HNEpC cells against LPS-induced inflammatory injury via inducing miR-21/DMBT1/NF-kappaB axis.	Quercetin	13-22	deleted in malignant brain tumors 1	Homo sapiens	109-114
34927513-10	2022	CONCLUSIONS: Quercetin could protect HNEpC cells against LPS-induced inflammatory injury via inducing miR-21/DMBT1/NF-kappaB axis.	Quercetin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	115-124
34922902-0	2022	The potential therapeutic effects of Trifolium alexandrinum extract, hesperetin and quercetin against diabetic nephropathy via attenuation of oxidative stress, inflammation, GSK-3beta and apoptosis in male rats.	Quercetin	84-93	glycogen synthase kinase 3 alpha	Rattus norvegicus	174-183
34959114-6	2022	Further, quercetin-containing composite increased the expression levels of OSX, RUNX2, OCN, ALP, BMP-2, OPN, BSP, SMAD2, and TGF-beta in BMSCs, while it downregulated TNF-alpha.	Quercetin	9-18	Sp7 transcription factor	Rattus norvegicus	75-78
34959114-6	2022	Further, quercetin-containing composite increased the expression levels of OSX, RUNX2, OCN, ALP, BMP-2, OPN, BSP, SMAD2, and TGF-beta in BMSCs, while it downregulated TNF-alpha.	Quercetin	9-18	RUNX family transcription factor 2	Rattus norvegicus	80-85
34959114-6	2022	Further, quercetin-containing composite increased the expression levels of OSX, RUNX2, OCN, ALP, BMP-2, OPN, BSP, SMAD2, and TGF-beta in BMSCs, while it downregulated TNF-alpha.	Quercetin	9-18	PDZ and LIM domain 3	Rattus norvegicus	92-95
34959114-6	2022	Further, quercetin-containing composite increased the expression levels of OSX, RUNX2, OCN, ALP, BMP-2, OPN, BSP, SMAD2, and TGF-beta in BMSCs, while it downregulated TNF-alpha.	Quercetin	9-18	bone morphogenetic protein 2	Rattus norvegicus	97-102
34959114-6	2022	Further, quercetin-containing composite increased the expression levels of OSX, RUNX2, OCN, ALP, BMP-2, OPN, BSP, SMAD2, and TGF-beta in BMSCs, while it downregulated TNF-alpha.	Quercetin	9-18	integrin-binding sialoprotein	Rattus norvegicus	109-112
34959114-6	2022	Further, quercetin-containing composite increased the expression levels of OSX, RUNX2, OCN, ALP, BMP-2, OPN, BSP, SMAD2, and TGF-beta in BMSCs, while it downregulated TNF-alpha.	Quercetin	9-18	SMAD family member 2	Rattus norvegicus	114-119
34959114-6	2022	Further, quercetin-containing composite increased the expression levels of OSX, RUNX2, OCN, ALP, BMP-2, OPN, BSP, SMAD2, and TGF-beta in BMSCs, while it downregulated TNF-alpha.	Quercetin	9-18	transforming growth factor alpha	Rattus norvegicus	125-133
34959114-6	2022	Further, quercetin-containing composite increased the expression levels of OSX, RUNX2, OCN, ALP, BMP-2, OPN, BSP, SMAD2, and TGF-beta in BMSCs, while it downregulated TNF-alpha.	Quercetin	9-18	tumor necrosis factor	Rattus norvegicus	167-176
34959114-9	2022	Moreover, immunofluorescence assay revealed that quercetin significantly increased the number of RUNX2/OSX/OCN-positive cells.	Quercetin	49-58	RUNX family transcription factor 2	Rattus norvegicus	97-102
34959114-9	2022	Moreover, immunofluorescence assay revealed that quercetin significantly increased the number of RUNX2/OSX/OCN-positive cells.	Quercetin	49-58	Sp7 transcription factor	Rattus norvegicus	103-106
34751495-10	2022	Conversely, quercetin pretreatment improved these renal histo-biochemical alterations (p < .05) and regulated autophagy/NF-kB pathways.	Quercetin	12-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-125
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	Quercetin	130-139	cyclin dependent kinase inhibitor 1A	Homo sapiens	233-239
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	Quercetin	130-139	BCL2 apoptosis regulator	Homo sapiens	241-245
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	Quercetin	130-139	E2F transcription factor 1	Homo sapiens	247-251
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	Quercetin	130-139	protein kinase C beta	Homo sapiens	253-258
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	Quercetin	130-139	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	260-263
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	Quercetin	130-139	cyclin dependent kinase 2	Homo sapiens	265-269
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	Quercetin	130-139	matrix metallopeptidase 9	Homo sapiens	274-278
34964624-2	2022	Results from thioflavin T assay demonstrated that gallic acid, caffeic acid, and rutin and its aglycone, quercetin, inhibited IAPP fibrillation at 1:0.5, 1:1, and 1:2 IAPP-phenolic molar ratios.	Quercetin	105-114	islet amyloid polypeptide	Homo sapiens	126-130
34964624-2	2022	Results from thioflavin T assay demonstrated that gallic acid, caffeic acid, and rutin and its aglycone, quercetin, inhibited IAPP fibrillation at 1:0.5, 1:1, and 1:2 IAPP-phenolic molar ratios.	Quercetin	105-114	islet amyloid polypeptide	Homo sapiens	167-171
34964624-7	2022	Molecular docking and TEM showed that rutin and quercetin disaggregated preformed IAPP fibrils potentially through fibrillar-monomeric equilibrium shifts.	Quercetin	48-57	islet amyloid polypeptide	Homo sapiens	82-86
34863994-5	2022	According to the results, taking quercetin was significantly associated with partial earlier discharge and reduced serum levels of ALP, q-CRP, and LDH in the intervention group.	Quercetin	33-42	ATHS	Homo sapiens	131-134
34863994-5	2022	According to the results, taking quercetin was significantly associated with partial earlier discharge and reduced serum levels of ALP, q-CRP, and LDH in the intervention group.	Quercetin	33-42	C-reactive protein	Homo sapiens	138-141
34863994-7	2022	Based on our observations, quercetin is safe and effective in lowering the serum levels of ALP, q-CRP, and LDH as critical markers involved in COVID-19 severity.	Quercetin	27-36	ATHS	Homo sapiens	91-94
34863994-7	2022	Based on our observations, quercetin is safe and effective in lowering the serum levels of ALP, q-CRP, and LDH as critical markers involved in COVID-19 severity.	Quercetin	27-36	C-reactive protein	Homo sapiens	98-101
34611857-0	2022	Formulation, Solubilization, and In Vitro Characterization of Quercetin-Incorporated Mixed Micelles of PEO-PPO-PEO Block Copolymers.	Quercetin	62-71	protoporphyrinogen oxidase	Homo sapiens	107-110
34813734-7	2022	Importantly, a senolytic cocktail, dasatinib plus quercetin, eliminates p21high cells in human fat ex vivo and mitigates insulin resistance following xenotransplantation into immuno-deficient mice.	Quercetin	50-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	72-75
34813734-7	2022	Importantly, a senolytic cocktail, dasatinib plus quercetin, eliminates p21high cells in human fat ex vivo and mitigates insulin resistance following xenotransplantation into immuno-deficient mice.	Quercetin	50-59	insulin	Homo sapiens	121-128
34855213-0	2022	Antidiabetic effects of quercetin and liraglutide combination through modulation of TXNIP/IRS-1/PI3K pathway.	Quercetin	24-33	thioredoxin interacting protein	Rattus norvegicus	84-89
34855213-0	2022	Antidiabetic effects of quercetin and liraglutide combination through modulation of TXNIP/IRS-1/PI3K pathway.	Quercetin	24-33	insulin receptor substrate 1	Rattus norvegicus	90-95
34855213-13	2022	Quercetin and/or liraglutide significantly decreased TXNIP levels and serine phosphorylation of IRS-1 and increased PI3K levels compared to the diabetic untreated group.	Quercetin	0-9	thioredoxin interacting protein	Rattus norvegicus	53-58
34855213-13	2022	Quercetin and/or liraglutide significantly decreased TXNIP levels and serine phosphorylation of IRS-1 and increased PI3K levels compared to the diabetic untreated group.	Quercetin	0-9	insulin receptor substrate 1	Rattus norvegicus	96-101
34855213-15	2022	The combination of quercetin and liraglutide showed enhanced antidiabetic effects, possibly through lowering hepatic TXNIP levels, with the resultant up-regulation of the IRS-1/PI3K pathway.	Quercetin	19-28	thioredoxin interacting protein	Rattus norvegicus	117-122
34855213-15	2022	The combination of quercetin and liraglutide showed enhanced antidiabetic effects, possibly through lowering hepatic TXNIP levels, with the resultant up-regulation of the IRS-1/PI3K pathway.	Quercetin	19-28	insulin receptor substrate 1	Rattus norvegicus	171-176
34365603-9	2022	Moreover, Que administration significantly alleviated systemic and vWAT inflammation, abolished NLRP3 inflammasome activation, and improved signaling abnormalities characteristic of insulin resistance in vWAT and adipocytes.	Quercetin	10-13	NLR family, pyrin domain containing 3	Mus musculus	96-101
34365603-11	2022	Most importantly, Que administration inhibited NLRP3 inflammasome-mediated inflammation and insulin signaling in vWAT to improve these adverse effects.	Quercetin	18-21	NLR family, pyrin domain containing 3	Mus musculus	47-52
34111449-8	2022	Quercetin and shRNA mediated knockdown of MRGPRX2 reduced P17-evoked beta-hexosaminidase release.	Quercetin	0-9	family with sequence similarity 72 member B	Homo sapiens	58-61
34743931-0	2022	3-(3-Hydroxyphenyl)propionic acid, a microbial metabolite of quercetin, inhibits monocyte binding to endothelial cells via modulating E-selectin expression.	Quercetin	61-70	selectin E	Homo sapiens	134-144
34111449-8	2022	Quercetin and shRNA mediated knockdown of MRGPRX2 reduced P17-evoked beta-hexosaminidase release.	Quercetin	0-9	O-GlcNAcase	Homo sapiens	69-88
34231170-9	2022	The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9.	Quercetin	24-33	AKT serine/threonine kinase 1	Homo sapiens	67-96
34785108-12	2022	Metascape enrichment analysis showed that 25 genes were significantly enriched in the NF-kappaB pathway, which were mainly targets of luteolin, quercetin, and kaempferol as confirmed by MS analysis.	Quercetin	144-153	nuclear factor kappa B subunit 1	Homo sapiens	86-95
34231170-9	2022	The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9.	Quercetin	24-33	mitogen-activated protein kinase 3	Homo sapiens	98-132
34231170-9	2022	The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9.	Quercetin	24-33	epidermal growth factor receptor	Homo sapiens	134-166
34231170-9	2022	The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9.	Quercetin	24-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	168-205
34231170-9	2022	The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9.	Quercetin	24-33	mitogen-activated protein kinase 1	Homo sapiens	207-241
34231170-9	2022	The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9.	Quercetin	24-33	estrogen receptor 1	Homo sapiens	243-262
34231170-9	2022	The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9.	Quercetin	24-33	heat shock protein 90 alpha family class A member 1	Homo sapiens	264-315
34231170-9	2022	The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9.	Quercetin	24-33	mitogen-activated protein kinase 8	Homo sapiens	317-351
34231170-9	2022	The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9.	Quercetin	24-33	androgen receptor	Homo sapiens	353-370
34231170-9	2022	The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9.	Quercetin	24-33	matrix metallopeptidase 9	Homo sapiens	376-401
34988084-6	2021	Molecular docking showed that two core active components, quercetin and licochalcone A, exhibited the highest component-like properties (DL), and could bind well to CDK1 and MAPK1 protein.	Quercetin	58-67	cyclin dependent kinase 1	Homo sapiens	165-169
34800883-6	2021	Nevertheless, although the expression of both pro-inflammatory genes, NF-kappaB and HIF-1alpha, was decreased when quercetin was administered to mice, this reduction was not statistically significant.	Quercetin	115-124	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	70-79
34800883-6	2021	Nevertheless, although the expression of both pro-inflammatory genes, NF-kappaB and HIF-1alpha, was decreased when quercetin was administered to mice, this reduction was not statistically significant.	Quercetin	115-124	hypoxia inducible factor 1, alpha subunit	Mus musculus	84-94
34931597-4	2021	Supplements such as quercetin and beta glucan (beta-glucan) were the top docked compounds to ACE2 receptor though they strongly interacted with CoV target protein.	Quercetin	20-29	angiotensin converting enzyme 2	Homo sapiens	93-97
34986125-9	2021	Finally, the binding modes of EGFR, IL1B, NOS3 and TP53 with quercetin were visualized.	Quercetin	61-70	epidermal growth factor receptor	Homo sapiens	30-34
34986125-9	2021	Finally, the binding modes of EGFR, IL1B, NOS3 and TP53 with quercetin were visualized.	Quercetin	61-70	interleukin 1 beta	Homo sapiens	36-40
34986125-9	2021	Finally, the binding modes of EGFR, IL1B, NOS3 and TP53 with quercetin were visualized.	Quercetin	61-70	nitric oxide synthase 3	Homo sapiens	42-46
34986125-9	2021	Finally, the binding modes of EGFR, IL1B, NOS3 and TP53 with quercetin were visualized.	Quercetin	61-70	tumor protein p53	Homo sapiens	51-55
34986125-10	2021	DISCUSSION AND CONCLUSION: Quercetin of Baiying Qinghou decoction showed therapeutic effect against laryngeal squamous cell carcinoma by regulating TP53, EGFR, NOS3 and IL1B involved with drug resistance and PI3K-AKT signaling pathway.	Quercetin	27-36	tumor protein p53	Homo sapiens	148-152
34986125-10	2021	DISCUSSION AND CONCLUSION: Quercetin of Baiying Qinghou decoction showed therapeutic effect against laryngeal squamous cell carcinoma by regulating TP53, EGFR, NOS3 and IL1B involved with drug resistance and PI3K-AKT signaling pathway.	Quercetin	27-36	epidermal growth factor receptor	Homo sapiens	154-158
34986125-10	2021	DISCUSSION AND CONCLUSION: Quercetin of Baiying Qinghou decoction showed therapeutic effect against laryngeal squamous cell carcinoma by regulating TP53, EGFR, NOS3 and IL1B involved with drug resistance and PI3K-AKT signaling pathway.	Quercetin	27-36	nitric oxide synthase 3	Homo sapiens	160-164
34986125-10	2021	DISCUSSION AND CONCLUSION: Quercetin of Baiying Qinghou decoction showed therapeutic effect against laryngeal squamous cell carcinoma by regulating TP53, EGFR, NOS3 and IL1B involved with drug resistance and PI3K-AKT signaling pathway.	Quercetin	27-36	interleukin 1 beta	Homo sapiens	169-173
34986125-10	2021	DISCUSSION AND CONCLUSION: Quercetin of Baiying Qinghou decoction showed therapeutic effect against laryngeal squamous cell carcinoma by regulating TP53, EGFR, NOS3 and IL1B involved with drug resistance and PI3K-AKT signaling pathway.	Quercetin	27-36	AKT serine/threonine kinase 1	Homo sapiens	213-216
34988084-6	2021	Molecular docking showed that two core active components, quercetin and licochalcone A, exhibited the highest component-like properties (DL), and could bind well to CDK1 and MAPK1 protein.	Quercetin	58-67	mitogen-activated protein kinase 1	Homo sapiens	174-179
34988084-7	2021	The experimental validation of these two components showed that quercetin inhibited cell growth through CDK1 dephosphorylation-mediated cell cycle arrest at G2/M phase in human AML U937 and HL60 cells, and licochalcone A induced cell differentiation in these leukemia cells via activation of MAPK1 and upregulation of CD11b.	Quercetin	64-73	cyclin dependent kinase 1	Homo sapiens	104-108
34988084-7	2021	The experimental validation of these two components showed that quercetin inhibited cell growth through CDK1 dephosphorylation-mediated cell cycle arrest at G2/M phase in human AML U937 and HL60 cells, and licochalcone A induced cell differentiation in these leukemia cells via activation of MAPK1 and upregulation of CD11b.	Quercetin	64-73	mitogen-activated protein kinase 1	Homo sapiens	292-297
34988084-7	2021	The experimental validation of these two components showed that quercetin inhibited cell growth through CDK1 dephosphorylation-mediated cell cycle arrest at G2/M phase in human AML U937 and HL60 cells, and licochalcone A induced cell differentiation in these leukemia cells via activation of MAPK1 and upregulation of CD11b.	Quercetin	64-73	integrin subunit alpha M	Homo sapiens	318-323
34975454-0	2021	Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in DeltaK280 TauRD-DsRed SH-SY5Y Cells.	Quercetin	18-27	neurotrophic receptor tyrosine kinase 2	Homo sapiens	81-85
34944525-5	2021	Evodiamine, berberine, genipin, palmitic acid, genistein, and quercetin were shown to regulate adipocytokine signaling pathway proteins which mainly involved tumor necrosis factor receptor 1, leptin receptor.	Quercetin	62-71	leptin receptor	Homo sapiens	192-207
34975454-8	2021	Treatments with 7,8-DHF, quercetin, and apigenin rescued the reduced HSPB1 and NRF2 and activated TRKB-mediated extracellular signal-regulated kinase (ERK) signaling to upregulate cAMP-response element binding protein (CREB) and its downstream antiapoptotic BCL2 apoptosis regulator (BCL2).	Quercetin	25-34	cAMP responsive element binding protein 1	Homo sapiens	180-217
34975454-8	2021	Treatments with 7,8-DHF, quercetin, and apigenin rescued the reduced HSPB1 and NRF2 and activated TRKB-mediated extracellular signal-regulated kinase (ERK) signaling to upregulate cAMP-response element binding protein (CREB) and its downstream antiapoptotic BCL2 apoptosis regulator (BCL2).	Quercetin	25-34	cAMP responsive element binding protein 1	Homo sapiens	219-223
34975454-8	2021	Treatments with 7,8-DHF, quercetin, and apigenin rescued the reduced HSPB1 and NRF2 and activated TRKB-mediated extracellular signal-regulated kinase (ERK) signaling to upregulate cAMP-response element binding protein (CREB) and its downstream antiapoptotic BCL2 apoptosis regulator (BCL2).	Quercetin	25-34	BCL2 apoptosis regulator	Homo sapiens	258-282
34975454-8	2021	Treatments with 7,8-DHF, quercetin, and apigenin rescued the reduced HSPB1 and NRF2 and activated TRKB-mediated extracellular signal-regulated kinase (ERK) signaling to upregulate cAMP-response element binding protein (CREB) and its downstream antiapoptotic BCL2 apoptosis regulator (BCL2).	Quercetin	25-34	BCL2 apoptosis regulator	Homo sapiens	284-288
34975454-10	2021	Our results suggest 7,8-DHF, quercetin, and apigenin targeting HSPB1, NRF2, and TRKB to reduce Tau aggregation and protect cells against Tau neurotoxicity and may provide new treatment strategies for AD.	Quercetin	29-38	microtubule associated protein tau	Homo sapiens	95-98
34975454-10	2021	Our results suggest 7,8-DHF, quercetin, and apigenin targeting HSPB1, NRF2, and TRKB to reduce Tau aggregation and protect cells against Tau neurotoxicity and may provide new treatment strategies for AD.	Quercetin	29-38	microtubule associated protein tau	Homo sapiens	137-140
34975454-7	2021	Among the tested flavones, 7,8-DHF, quercetin, and apigenin reduced Tau aggregation, oxidative stress, and caspase-1 activity as well as improved neurite outgrowth in SH-SY5Y cells expressing DeltaK280 TauRD-DsRed folding reporter.	Quercetin	36-45	microtubule associated protein tau	Homo sapiens	68-71
34975454-7	2021	Among the tested flavones, 7,8-DHF, quercetin, and apigenin reduced Tau aggregation, oxidative stress, and caspase-1 activity as well as improved neurite outgrowth in SH-SY5Y cells expressing DeltaK280 TauRD-DsRed folding reporter.	Quercetin	36-45	caspase 1	Homo sapiens	107-116
34975454-8	2021	Treatments with 7,8-DHF, quercetin, and apigenin rescued the reduced HSPB1 and NRF2 and activated TRKB-mediated extracellular signal-regulated kinase (ERK) signaling to upregulate cAMP-response element binding protein (CREB) and its downstream antiapoptotic BCL2 apoptosis regulator (BCL2).	Quercetin	25-34	heat shock protein family B (small) member 1	Homo sapiens	69-74
34975454-8	2021	Treatments with 7,8-DHF, quercetin, and apigenin rescued the reduced HSPB1 and NRF2 and activated TRKB-mediated extracellular signal-regulated kinase (ERK) signaling to upregulate cAMP-response element binding protein (CREB) and its downstream antiapoptotic BCL2 apoptosis regulator (BCL2).	Quercetin	25-34	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
34975454-8	2021	Treatments with 7,8-DHF, quercetin, and apigenin rescued the reduced HSPB1 and NRF2 and activated TRKB-mediated extracellular signal-regulated kinase (ERK) signaling to upregulate cAMP-response element binding protein (CREB) and its downstream antiapoptotic BCL2 apoptosis regulator (BCL2).	Quercetin	25-34	neurotrophic receptor tyrosine kinase 2	Homo sapiens	98-102
34975454-8	2021	Treatments with 7,8-DHF, quercetin, and apigenin rescued the reduced HSPB1 and NRF2 and activated TRKB-mediated extracellular signal-regulated kinase (ERK) signaling to upregulate cAMP-response element binding protein (CREB) and its downstream antiapoptotic BCL2 apoptosis regulator (BCL2).	Quercetin	25-34	mitogen-activated protein kinase 1	Homo sapiens	112-149
34975454-8	2021	Treatments with 7,8-DHF, quercetin, and apigenin rescued the reduced HSPB1 and NRF2 and activated TRKB-mediated extracellular signal-regulated kinase (ERK) signaling to upregulate cAMP-response element binding protein (CREB) and its downstream antiapoptotic BCL2 apoptosis regulator (BCL2).	Quercetin	25-34	mitogen-activated protein kinase 1	Homo sapiens	151-154
34945647-8	2021	The synergistic group (lycopene:quercetin = 1:5) increased the expression of SR-BI compared to individual lycopene treatment in HUVEC and Caco-2 cells.	Quercetin	32-41	scavenger receptor class B member 1	Homo sapiens	77-82
34945647-4	2021	Lycopene combined with quercetin at ratio 1:5 showed stronger ROS scavenging activities, increased 18, 12, and 12 Cellular antioxidant activity (CAA) units in HUVEC, Caco-2, and L-02 cells, respectively, and promoted SOD and CAT activities than individual component.	Quercetin	23-32	catalase	Homo sapiens	225-228
34946657-10	2021	Finally, our results indicated that kaempferol and quercetin therapied the bacterial coinfection by inhibiting S. aureus alpha-hemolysin (Hla) and reduced the host inflammatory response.	Quercetin	51-60	AT695_RS11870	Staphylococcus aureus	121-136
34906197-0	2021	Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth.	Quercetin	26-35	nuclear receptor subfamily 4 group A member 1	Homo sapiens	40-60
34906197-0	2021	Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth.	Quercetin	26-35	nuclear receptor subfamily 4 group A member 1	Homo sapiens	62-67
34906197-0	2021	Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth.	Quercetin	26-35	nuclear receptor subfamily 4 group A member 1	Homo sapiens	69-74
34906197-2	2021	Based on some of their functional and gene modifying activities as anticancer agents, we hypothesized that kaempferol and quercetin were nuclear receptor 4A1 (NR4A1, Nur77) ligands and confirmed that both compounds directly bound NR4A1 with KD values of 3.1 and 0.93 muM, respectively.	Quercetin	122-131	nuclear receptor subfamily 4 group A member 1	Homo sapiens	137-157
34906197-2	2021	Based on some of their functional and gene modifying activities as anticancer agents, we hypothesized that kaempferol and quercetin were nuclear receptor 4A1 (NR4A1, Nur77) ligands and confirmed that both compounds directly bound NR4A1 with KD values of 3.1 and 0.93 muM, respectively.	Quercetin	122-131	nuclear receptor subfamily 4 group A member 1	Homo sapiens	159-164
34906197-2	2021	Based on some of their functional and gene modifying activities as anticancer agents, we hypothesized that kaempferol and quercetin were nuclear receptor 4A1 (NR4A1, Nur77) ligands and confirmed that both compounds directly bound NR4A1 with KD values of 3.1 and 0.93 muM, respectively.	Quercetin	122-131	nuclear receptor subfamily 4 group A member 1	Homo sapiens	166-171
34906197-2	2021	Based on some of their functional and gene modifying activities as anticancer agents, we hypothesized that kaempferol and quercetin were nuclear receptor 4A1 (NR4A1, Nur77) ligands and confirmed that both compounds directly bound NR4A1 with KD values of 3.1 and 0.93 muM, respectively.	Quercetin	122-131	nuclear receptor subfamily 4 group A member 1	Homo sapiens	230-235
34906197-3	2021	METHODS: The activities of kaempferol and quercetin were determined in direct binding to NR4A1 protein and in NR4A1-dependent transactivation assays in Rh30 and Rh41 rhabdomyosarcoma (RMS) cells.	Quercetin	42-51	nuclear receptor subfamily 4 group A member 1	Homo sapiens	89-94
34906197-3	2021	METHODS: The activities of kaempferol and quercetin were determined in direct binding to NR4A1 protein and in NR4A1-dependent transactivation assays in Rh30 and Rh41 rhabdomyosarcoma (RMS) cells.	Quercetin	42-51	nuclear receptor subfamily 4 group A member 1	Homo sapiens	110-115
34906197-6	2021	RESULTS: Kaempferol and quercetin bind NR4A1 protein and inhibit NR4A1-dependent transactivation in RMS cells.	Quercetin	24-33	nuclear receptor subfamily 4 group A member 1	Homo sapiens	39-44
34906197-6	2021	RESULTS: Kaempferol and quercetin bind NR4A1 protein and inhibit NR4A1-dependent transactivation in RMS cells.	Quercetin	24-33	nuclear receptor subfamily 4 group A member 1	Homo sapiens	65-70
34906197-8	2021	The pro-oncogenic PAX3-FOXO1 and G9a genes are also regulated by NR4A1 and, these pathways and genes are all inhibited by kaempferol and quercetin.	Quercetin	137-146	paired box 3	Homo sapiens	18-22
34889224-8	2021	The molecular docking results showed the components that docked well with key targets were quercetin, luteolin, kaempferol, and baicalein.The active components (quercetin, luteolin, kaempferol, and baicalein) of the RPR-FC and their targets act on proteins such as MAPK1, AKT1, VEGFA, and CASP3, which are closely related to IS.1 These targets are closely related to the NF-kappa B signaling pathway, the MAPK signaling pathway, the PI3K-Akt signaling pathway, the VEGF signaling pathway, and other signaling pathways.	Quercetin	161-170	mitogen-activated protein kinase 1	Homo sapiens	265-270
34906197-8	2021	The pro-oncogenic PAX3-FOXO1 and G9a genes are also regulated by NR4A1 and, these pathways and genes are all inhibited by kaempferol and quercetin.	Quercetin	137-146	forkhead box O1	Homo sapiens	23-28
34906197-8	2021	The pro-oncogenic PAX3-FOXO1 and G9a genes are also regulated by NR4A1 and, these pathways and genes are all inhibited by kaempferol and quercetin.	Quercetin	137-146	euchromatic histone lysine methyltransferase 2	Homo sapiens	33-36
34906197-8	2021	The pro-oncogenic PAX3-FOXO1 and G9a genes are also regulated by NR4A1 and, these pathways and genes are all inhibited by kaempferol and quercetin.	Quercetin	137-146	nuclear receptor subfamily 4 group A member 1	Homo sapiens	65-70
34906197-10	2021	CONCLUSION: These results demonstrate the clinical potential for repurposing kaempferol and quercetin for clinical applications as precision medicine for treating RMS patients that express NR4A1 in order to increase the efficacy and decrease dosages of currently used cytotoxic drugs.	Quercetin	92-101	nuclear receptor subfamily 4 group A member 1	Homo sapiens	189-194
34889224-8	2021	The molecular docking results showed the components that docked well with key targets were quercetin, luteolin, kaempferol, and baicalein.The active components (quercetin, luteolin, kaempferol, and baicalein) of the RPR-FC and their targets act on proteins such as MAPK1, AKT1, VEGFA, and CASP3, which are closely related to IS.1 These targets are closely related to the NF-kappa B signaling pathway, the MAPK signaling pathway, the PI3K-Akt signaling pathway, the VEGF signaling pathway, and other signaling pathways.	Quercetin	161-170	AKT serine/threonine kinase 1	Homo sapiens	272-276
34889224-8	2021	The molecular docking results showed the components that docked well with key targets were quercetin, luteolin, kaempferol, and baicalein.The active components (quercetin, luteolin, kaempferol, and baicalein) of the RPR-FC and their targets act on proteins such as MAPK1, AKT1, VEGFA, and CASP3, which are closely related to IS.1 These targets are closely related to the NF-kappa B signaling pathway, the MAPK signaling pathway, the PI3K-Akt signaling pathway, the VEGF signaling pathway, and other signaling pathways.	Quercetin	161-170	vascular endothelial growth factor A	Homo sapiens	278-283
34889224-8	2021	The molecular docking results showed the components that docked well with key targets were quercetin, luteolin, kaempferol, and baicalein.The active components (quercetin, luteolin, kaempferol, and baicalein) of the RPR-FC and their targets act on proteins such as MAPK1, AKT1, VEGFA, and CASP3, which are closely related to IS.1 These targets are closely related to the NF-kappa B signaling pathway, the MAPK signaling pathway, the PI3K-Akt signaling pathway, the VEGF signaling pathway, and other signaling pathways.	Quercetin	161-170	caspase 3	Homo sapiens	289-294
34889224-8	2021	The molecular docking results showed the components that docked well with key targets were quercetin, luteolin, kaempferol, and baicalein.The active components (quercetin, luteolin, kaempferol, and baicalein) of the RPR-FC and their targets act on proteins such as MAPK1, AKT1, VEGFA, and CASP3, which are closely related to IS.1 These targets are closely related to the NF-kappa B signaling pathway, the MAPK signaling pathway, the PI3K-Akt signaling pathway, the VEGF signaling pathway, and other signaling pathways.	Quercetin	161-170	nuclear factor kappa B subunit 1	Homo sapiens	371-381
34889224-8	2021	The molecular docking results showed the components that docked well with key targets were quercetin, luteolin, kaempferol, and baicalein.The active components (quercetin, luteolin, kaempferol, and baicalein) of the RPR-FC and their targets act on proteins such as MAPK1, AKT1, VEGFA, and CASP3, which are closely related to IS.1 These targets are closely related to the NF-kappa B signaling pathway, the MAPK signaling pathway, the PI3K-Akt signaling pathway, the VEGF signaling pathway, and other signaling pathways.	Quercetin	161-170	mitogen-activated protein kinase 1	Homo sapiens	405-409
34889224-8	2021	The molecular docking results showed the components that docked well with key targets were quercetin, luteolin, kaempferol, and baicalein.The active components (quercetin, luteolin, kaempferol, and baicalein) of the RPR-FC and their targets act on proteins such as MAPK1, AKT1, VEGFA, and CASP3, which are closely related to IS.1 These targets are closely related to the NF-kappa B signaling pathway, the MAPK signaling pathway, the PI3K-Akt signaling pathway, the VEGF signaling pathway, and other signaling pathways.	Quercetin	161-170	AKT serine/threonine kinase 1	Homo sapiens	438-441
34889224-8	2021	The molecular docking results showed the components that docked well with key targets were quercetin, luteolin, kaempferol, and baicalein.The active components (quercetin, luteolin, kaempferol, and baicalein) of the RPR-FC and their targets act on proteins such as MAPK1, AKT1, VEGFA, and CASP3, which are closely related to IS.1 These targets are closely related to the NF-kappa B signaling pathway, the MAPK signaling pathway, the PI3K-Akt signaling pathway, the VEGF signaling pathway, and other signaling pathways.	Quercetin	161-170	vascular endothelial growth factor A	Homo sapiens	465-469
34743981-0	2021	Quercetin reduces inflammation in a rat model of diabetic peripheral neuropathy by regulating the TLR4/MyD88/NF-kappaB signalling pathway.	Quercetin	0-9	toll-like receptor 4	Rattus norvegicus	98-102
34950037-8	2021	In vitro, Quercetin, Methyl rosmarinate, Kaempferol, Diosmetin and Acacetin were demonstrated to retard podocyte proliferation by inhibiting DPP4 activity and were the top five compounds predicted by molecular docking to be the most likely to affect DPP4 activity.	Quercetin	10-19	dipeptidylpeptidase 4	Mus musculus	141-145
34950037-8	2021	In vitro, Quercetin, Methyl rosmarinate, Kaempferol, Diosmetin and Acacetin were demonstrated to retard podocyte proliferation by inhibiting DPP4 activity and were the top five compounds predicted by molecular docking to be the most likely to affect DPP4 activity.	Quercetin	10-19	dipeptidylpeptidase 4	Mus musculus	250-254
34946608-5	2021	The results from brain-to-body weight ratio, morphology, lipid peroxidation, brain urea, ascorbic acid, reduced glutathione, sodium, and enzyme alterations (aspartate aminotransferase (AST), alanine aminotransferase (ALT), catalase, and superoxide dismutase) suggested alterations by CCL4 and a significant reversal of these parameters by quercetin.	Quercetin	339-348	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	157-183
34946608-5	2021	The results from brain-to-body weight ratio, morphology, lipid peroxidation, brain urea, ascorbic acid, reduced glutathione, sodium, and enzyme alterations (aspartate aminotransferase (AST), alanine aminotransferase (ALT), catalase, and superoxide dismutase) suggested alterations by CCL4 and a significant reversal of these parameters by quercetin.	Quercetin	339-348	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	185-188
34946608-5	2021	The results from brain-to-body weight ratio, morphology, lipid peroxidation, brain urea, ascorbic acid, reduced glutathione, sodium, and enzyme alterations (aspartate aminotransferase (AST), alanine aminotransferase (ALT), catalase, and superoxide dismutase) suggested alterations by CCL4 and a significant reversal of these parameters by quercetin.	Quercetin	339-348	catalase	Rattus norvegicus	223-231
34946608-7	2021	The results identified by BzScore4 D showed moderate binding between quercetin and the following receptors: glucocorticoids, estrogen beta, and androgens and weak binding between quercetin and the following proteins: estrogen alpha, Peroxisome proliferator-activated receptors (PPARgamma), Herg k+ channel, Liver x, mineralocorticoid, progesterone, Thyroid alpha, and Thyroid beta.	Quercetin	179-188	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	278-287
34946608-9	2021	Based on the results, a possible mechanism is hypothesized for quercetin protection against CCL4 toxicity in the rat brain.	Quercetin	63-72	C-C motif chemokine ligand 4	Rattus norvegicus	92-96
34743981-0	2021	Quercetin reduces inflammation in a rat model of diabetic peripheral neuropathy by regulating the TLR4/MyD88/NF-kappaB signalling pathway.	Quercetin	0-9	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	103-108
34743981-9	2021	Quercetin significantly alleviated the increased expression of TNF-alpha (p < 0.05) and IL-1beta (p < 0.001).	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	63-72
34743981-9	2021	Quercetin significantly alleviated the increased expression of TNF-alpha (p < 0.05) and IL-1beta (p < 0.001).	Quercetin	0-9	interleukin 1 alpha	Rattus norvegicus	88-96
34743981-10	2021	Furthermore, high-dose quercetin administration significantly downregulated the expression of TLR4 (p < 0.001), MyD88 (p < 0.001), and NF-kappaB (p < 0.001) in sciatic nerves of DPN rats.	Quercetin	23-32	toll-like receptor 4	Rattus norvegicus	94-98
34743981-10	2021	Furthermore, high-dose quercetin administration significantly downregulated the expression of TLR4 (p < 0.001), MyD88 (p < 0.001), and NF-kappaB (p < 0.001) in sciatic nerves of DPN rats.	Quercetin	23-32	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	112-117
34743981-11	2021	Our findings revealed that quercetin could reduce the levels of inflammatory factors in DPN rats, possibly mediated via the downregulation of the TLR4/MyD88/NF-kappaB signalling pathway.	Quercetin	27-36	toll-like receptor 4	Rattus norvegicus	146-150
34854272-0	2022	Quercetin increases mitochondrial proteins (VDAC and SDH) and downmodulates AXL and PIM-1 tyrosine kinase receptors in NRAS melanoma cells.	Quercetin	0-9	serine dehydratase	Homo sapiens	53-56
34743981-11	2021	Our findings revealed that quercetin could reduce the levels of inflammatory factors in DPN rats, possibly mediated via the downregulation of the TLR4/MyD88/NF-kappaB signalling pathway.	Quercetin	27-36	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	151-156
34854272-0	2022	Quercetin increases mitochondrial proteins (VDAC and SDH) and downmodulates AXL and PIM-1 tyrosine kinase receptors in NRAS melanoma cells.	Quercetin	0-9	AXL receptor tyrosine kinase	Homo sapiens	76-79
34959345-7	2021	We found that quercetin, quercetin-3-glucoside, narcissoside and ellagic acid inhibited the ATPase activity of Pgp and increased the accumulation of calcein and daunorubicin by Pgp-positive cells.	Quercetin	14-23	ATP binding cassette subfamily B member 1	Homo sapiens	111-114
34854272-0	2022	Quercetin increases mitochondrial proteins (VDAC and SDH) and downmodulates AXL and PIM-1 tyrosine kinase receptors in NRAS melanoma cells.	Quercetin	0-9	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	84-89
34854272-4	2022	Besides that, quercetin treatment caused inhibition of AXL in both cell lines, but upregulation of PIM-1 in SKMEL-28 and downregulation in SKMEL-103.	Quercetin	14-23	AXL receptor tyrosine kinase	Homo sapiens	55-58
34854272-4	2022	Besides that, quercetin treatment caused inhibition of AXL in both cell lines, but upregulation of PIM-1 in SKMEL-28 and downregulation in SKMEL-103.	Quercetin	14-23	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	99-104
34959345-7	2021	We found that quercetin, quercetin-3-glucoside, narcissoside and ellagic acid inhibited the ATPase activity of Pgp and increased the accumulation of calcein and daunorubicin by Pgp-positive cells.	Quercetin	14-23	ATP binding cassette subfamily B member 1	Homo sapiens	177-180
34448661-0	2021	Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRNA SNHG7/miR-34a-5p pathway.	Quercetin	0-9	small nucleolar RNA host gene 7	Mus musculus	106-111
34854117-5	2022	However, quercetin co-administration significantly (p < 0.05) prevented the increased values of IDO, TDO, MPO, IL-6, IFN-gamma, MDA, SOD, CAT, GSH-Px and GSH compared with control rats.	Quercetin	9-18	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	96-99
34854117-5	2022	However, quercetin co-administration significantly (p < 0.05) prevented the increased values of IDO, TDO, MPO, IL-6, IFN-gamma, MDA, SOD, CAT, GSH-Px and GSH compared with control rats.	Quercetin	9-18	tryptophan 2,3-dioxygenase	Rattus norvegicus	101-104
34854117-5	2022	However, quercetin co-administration significantly (p < 0.05) prevented the increased values of IDO, TDO, MPO, IL-6, IFN-gamma, MDA, SOD, CAT, GSH-Px and GSH compared with control rats.	Quercetin	9-18	myeloperoxidase	Rattus norvegicus	106-109
34854117-5	2022	However, quercetin co-administration significantly (p < 0.05) prevented the increased values of IDO, TDO, MPO, IL-6, IFN-gamma, MDA, SOD, CAT, GSH-Px and GSH compared with control rats.	Quercetin	9-18	interleukin 6	Rattus norvegicus	111-115
34854117-5	2022	However, quercetin co-administration significantly (p < 0.05) prevented the increased values of IDO, TDO, MPO, IL-6, IFN-gamma, MDA, SOD, CAT, GSH-Px and GSH compared with control rats.	Quercetin	9-18	interferon gamma	Rattus norvegicus	117-126
34854117-5	2022	However, quercetin co-administration significantly (p < 0.05) prevented the increased values of IDO, TDO, MPO, IL-6, IFN-gamma, MDA, SOD, CAT, GSH-Px and GSH compared with control rats.	Quercetin	9-18	catalase	Rattus norvegicus	138-141
34854117-6	2022	Also, quercetin co-treatment significantly increased serum testosterone, follicle-stimulating hormone (FSH), prolactin, luteinizing hormone (LH), activities of testicular 3beta-hydroxysteroid dehydrogenase (3 beta-HSD), 17beta-hydroxysteroid dehydrogenase (17 beta-HSD) as well as sperm count, motility and viability but reduced abnormal sperm morphology.	Quercetin	6-15	prolactin	Rattus norvegicus	109-118
34854117-6	2022	Also, quercetin co-treatment significantly increased serum testosterone, follicle-stimulating hormone (FSH), prolactin, luteinizing hormone (LH), activities of testicular 3beta-hydroxysteroid dehydrogenase (3 beta-HSD), 17beta-hydroxysteroid dehydrogenase (17 beta-HSD) as well as sperm count, motility and viability but reduced abnormal sperm morphology.	Quercetin	6-15	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	257-268
34854117-8	2022	Thus, quercetin protected the testes against cyclophosphamide-induced alterations in immunosuppressive IDO/TDO activities elicited by oxidative-inflammatory mediators.	Quercetin	6-15	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	103-106
34854117-8	2022	Thus, quercetin protected the testes against cyclophosphamide-induced alterations in immunosuppressive IDO/TDO activities elicited by oxidative-inflammatory mediators.	Quercetin	6-15	tryptophan 2,3-dioxygenase	Rattus norvegicus	107-110
34077310-4	2021	According to the "Drug-Ingredients-Targets-Disease" network built by STRING and Cytoscape, AKT1 was identified as the core target, and baicalein, luteolin, and quercetin were identified as the active ingredients of the Xuebijing injection in connection with AKT1.	Quercetin	160-169	AKT serine/threonine kinase 1	Homo sapiens	258-262
34528858-0	2021	Quercetin alleviates chronic renal failure by targeting the PI3k/Akt pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
34528858-4	2021	In this study, we investigated the effect of Quercetin monomer on CRF and the regulation of PI3k/Akt pathway.	Quercetin	45-54	AKT serine/threonine kinase 1	Homo sapiens	97-100
34528858-10	2021	Furthermore, the protein expression of p-PI3K, p-AKT, NLRP3, caspase1, AQP1, and AQP2 in all groups was detected by immunofluorescence and western blot assays, indicating that Quercetin could reduce the expression of NLRP3, caspase1, p-PI3k, and p-Akt, and increase the expression of AQP1 and AQP2 in the renal tissues of CRF rats.	Quercetin	176-185	AKT serine/threonine kinase 1	Rattus norvegicus	49-52
34528858-10	2021	Furthermore, the protein expression of p-PI3K, p-AKT, NLRP3, caspase1, AQP1, and AQP2 in all groups was detected by immunofluorescence and western blot assays, indicating that Quercetin could reduce the expression of NLRP3, caspase1, p-PI3k, and p-Akt, and increase the expression of AQP1 and AQP2 in the renal tissues of CRF rats.	Quercetin	176-185	NLR family, pyrin domain containing 3	Rattus norvegicus	54-59
34528858-10	2021	Furthermore, the protein expression of p-PI3K, p-AKT, NLRP3, caspase1, AQP1, and AQP2 in all groups was detected by immunofluorescence and western blot assays, indicating that Quercetin could reduce the expression of NLRP3, caspase1, p-PI3k, and p-Akt, and increase the expression of AQP1 and AQP2 in the renal tissues of CRF rats.	Quercetin	176-185	caspase 1	Rattus norvegicus	61-69
34528858-10	2021	Furthermore, the protein expression of p-PI3K, p-AKT, NLRP3, caspase1, AQP1, and AQP2 in all groups was detected by immunofluorescence and western blot assays, indicating that Quercetin could reduce the expression of NLRP3, caspase1, p-PI3k, and p-Akt, and increase the expression of AQP1 and AQP2 in the renal tissues of CRF rats.	Quercetin	176-185	aquaporin 1	Rattus norvegicus	71-75
34528858-10	2021	Furthermore, the protein expression of p-PI3K, p-AKT, NLRP3, caspase1, AQP1, and AQP2 in all groups was detected by immunofluorescence and western blot assays, indicating that Quercetin could reduce the expression of NLRP3, caspase1, p-PI3k, and p-Akt, and increase the expression of AQP1 and AQP2 in the renal tissues of CRF rats.	Quercetin	176-185	aquaporin 2	Rattus norvegicus	81-85
34528858-10	2021	Furthermore, the protein expression of p-PI3K, p-AKT, NLRP3, caspase1, AQP1, and AQP2 in all groups was detected by immunofluorescence and western blot assays, indicating that Quercetin could reduce the expression of NLRP3, caspase1, p-PI3k, and p-Akt, and increase the expression of AQP1 and AQP2 in the renal tissues of CRF rats.	Quercetin	176-185	NLR family, pyrin domain containing 3	Rattus norvegicus	217-222
34528858-10	2021	Furthermore, the protein expression of p-PI3K, p-AKT, NLRP3, caspase1, AQP1, and AQP2 in all groups was detected by immunofluorescence and western blot assays, indicating that Quercetin could reduce the expression of NLRP3, caspase1, p-PI3k, and p-Akt, and increase the expression of AQP1 and AQP2 in the renal tissues of CRF rats.	Quercetin	176-185	caspase 1	Rattus norvegicus	224-232
34528858-10	2021	Furthermore, the protein expression of p-PI3K, p-AKT, NLRP3, caspase1, AQP1, and AQP2 in all groups was detected by immunofluorescence and western blot assays, indicating that Quercetin could reduce the expression of NLRP3, caspase1, p-PI3k, and p-Akt, and increase the expression of AQP1 and AQP2 in the renal tissues of CRF rats.	Quercetin	176-185	AKT serine/threonine kinase 1	Rattus norvegicus	248-251
34528858-10	2021	Furthermore, the protein expression of p-PI3K, p-AKT, NLRP3, caspase1, AQP1, and AQP2 in all groups was detected by immunofluorescence and western blot assays, indicating that Quercetin could reduce the expression of NLRP3, caspase1, p-PI3k, and p-Akt, and increase the expression of AQP1 and AQP2 in the renal tissues of CRF rats.	Quercetin	176-185	aquaporin 1	Rattus norvegicus	284-288
34528858-10	2021	Furthermore, the protein expression of p-PI3K, p-AKT, NLRP3, caspase1, AQP1, and AQP2 in all groups was detected by immunofluorescence and western blot assays, indicating that Quercetin could reduce the expression of NLRP3, caspase1, p-PI3k, and p-Akt, and increase the expression of AQP1 and AQP2 in the renal tissues of CRF rats.	Quercetin	176-185	aquaporin 2	Rattus norvegicus	293-297
34528858-11	2021	Being labeled with biotin and incubated with the total protein extracted from kidney tissues, Quercetin could bind to PIK3R1.	Quercetin	94-103	phosphoinositide-3-kinase regulatory subunit 1	Rattus norvegicus	118-124
34528858-12	2021	Following the PIK3R1 interference lentivirus was injected into the CRF model rats by tail vein, the CRF symptoms were effectively alleviated in the PIK3R1 interference group, consistent with the effect of Quercetin.	Quercetin	205-214	phosphoinositide-3-kinase regulatory subunit 1	Rattus norvegicus	14-20
34528858-12	2021	Following the PIK3R1 interference lentivirus was injected into the CRF model rats by tail vein, the CRF symptoms were effectively alleviated in the PIK3R1 interference group, consistent with the effect of Quercetin.	Quercetin	205-214	phosphoinositide-3-kinase regulatory subunit 1	Rattus norvegicus	148-154
34529966-0	2021	Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	107-141
34529966-4	2021	The present study aimed to investigate the antidepressant effect of quercetin in vivo on a CUMS-induced depression model that is closest to human depression, and to explore its mechanism of action around nuclear factor-E2-related factor 2 (Nrf2) related signaling pathways, for the first time.	Quercetin	68-77	NFE2 like bZIP transcription factor 2	Homo sapiens	204-238
34529966-4	2021	The present study aimed to investigate the antidepressant effect of quercetin in vivo on a CUMS-induced depression model that is closest to human depression, and to explore its mechanism of action around nuclear factor-E2-related factor 2 (Nrf2) related signaling pathways, for the first time.	Quercetin	68-77	NFE2 like bZIP transcription factor 2	Homo sapiens	240-244
34529966-9	2021	Collectively, the present study confirmed for the first time that quercetin weakened CUMS-induced depression in vivo, and its mechanism was at least partially attributable to the upregulation of hippocampal Nrf2 and the inhibition of iNOS, thereby correcting the central inflammatory response, and the imbalance between oxidation and antioxidant.	Quercetin	66-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	207-211
34529966-9	2021	Collectively, the present study confirmed for the first time that quercetin weakened CUMS-induced depression in vivo, and its mechanism was at least partially attributable to the upregulation of hippocampal Nrf2 and the inhibition of iNOS, thereby correcting the central inflammatory response, and the imbalance between oxidation and antioxidant.	Quercetin	66-75	nitric oxide synthase 2, inducible	Mus musculus	234-238
34219513-0	2021	Quercetin inhibited the proliferation and invasion of hepatoblastoma cells through facilitating SIRT6-medicated FZD4 silence.	Quercetin	0-9	sirtuin 6	Mus musculus	96-101
34219513-0	2021	Quercetin inhibited the proliferation and invasion of hepatoblastoma cells through facilitating SIRT6-medicated FZD4 silence.	Quercetin	0-9	frizzled class receptor 4	Mus musculus	112-116
34219513-9	2021	Additionally, quercetin treatment could enhance the expression of SIRT6, repress FZD4 level, cell viability and invasion, and promote apoptosis.	Quercetin	14-23	sirtuin 6	Mus musculus	66-71
34219513-9	2021	Additionally, quercetin treatment could enhance the expression of SIRT6, repress FZD4 level, cell viability and invasion, and promote apoptosis.	Quercetin	14-23	frizzled class receptor 4	Mus musculus	81-85
34219513-10	2021	Overexpression of FZD4 signally reversed quercetin-treated the promotion effect on cell apoptosis, and the inhibition effects on FZD4 expression, cell viability, invasion and Wnt/beta-catenin pathway related proteins.	Quercetin	41-50	frizzled class receptor 4	Mus musculus	18-22
34219513-10	2021	Overexpression of FZD4 signally reversed quercetin-treated the promotion effect on cell apoptosis, and the inhibition effects on FZD4 expression, cell viability, invasion and Wnt/beta-catenin pathway related proteins.	Quercetin	41-50	frizzled class receptor 4	Mus musculus	129-133
34219513-10	2021	Overexpression of FZD4 signally reversed quercetin-treated the promotion effect on cell apoptosis, and the inhibition effects on FZD4 expression, cell viability, invasion and Wnt/beta-catenin pathway related proteins.	Quercetin	41-50	catenin (cadherin associated protein), beta 1	Mus musculus	179-191
34219513-11	2021	In addition, LiCl, an agonist of Wnt/beta-catenin pathway, could recover the inhibition effects of quercetin on Wnt/beta-catenin pathway related proteins, cell viability and invasion, and promotion effect on cell apoptosis.	Quercetin	99-108	catenin (cadherin associated protein), beta 1	Mus musculus	37-49
34219513-11	2021	In addition, LiCl, an agonist of Wnt/beta-catenin pathway, could recover the inhibition effects of quercetin on Wnt/beta-catenin pathway related proteins, cell viability and invasion, and promotion effect on cell apoptosis.	Quercetin	99-108	catenin (cadherin associated protein), beta 1	Mus musculus	116-128
34219513-13	2021	In conclusion, these results demonstrated that the molecular mechanism of quercetin suppressing HB cell proliferation and invasion, promoting apoptosis was to promote the deacetylation of SIRT6 on FZD4 and inhibit the activation of Wnt/beta-catenin pathway.	Quercetin	74-83	sirtuin 6	Mus musculus	188-193
34219513-13	2021	In conclusion, these results demonstrated that the molecular mechanism of quercetin suppressing HB cell proliferation and invasion, promoting apoptosis was to promote the deacetylation of SIRT6 on FZD4 and inhibit the activation of Wnt/beta-catenin pathway.	Quercetin	74-83	frizzled class receptor 4	Mus musculus	197-201
34219513-13	2021	In conclusion, these results demonstrated that the molecular mechanism of quercetin suppressing HB cell proliferation and invasion, promoting apoptosis was to promote the deacetylation of SIRT6 on FZD4 and inhibit the activation of Wnt/beta-catenin pathway.	Quercetin	74-83	catenin (cadherin associated protein), beta 1	Mus musculus	236-248
34844154-0	2021	Quercetin regulates inflammation, oxidative stress, apoptosis, and mitochondrial structure and function in H9C2 cells by promoting PVT1 expression.	Quercetin	0-9	Pvt1 oncogene	Rattus norvegicus	131-135
34844154-11	2021	Moreover, MDA expression was significantly lower in the OV, quercetin, quercetin + OV, and NAC groups than in the model group (P < 0.05), while SOD, eNOS, and ATP levels were higher.	Quercetin	60-69	nitric oxide synthase 3	Rattus norvegicus	149-153
34844154-11	2021	Moreover, MDA expression was significantly lower in the OV, quercetin, quercetin + OV, and NAC groups than in the model group (P < 0.05), while SOD, eNOS, and ATP levels were higher.	Quercetin	71-80	nitric oxide synthase 3	Rattus norvegicus	149-153
34528858-13	2021	Taken together, Quercetin, a major component of SQJZJN, might minimize renal fibrosis and apoptosis in CRF rats by inhibiting the PI3k/Akt pathway through targeting PIK3R1.	Quercetin	16-25	AKT serine/threonine kinase 1	Rattus norvegicus	135-138
34528858-13	2021	Taken together, Quercetin, a major component of SQJZJN, might minimize renal fibrosis and apoptosis in CRF rats by inhibiting the PI3k/Akt pathway through targeting PIK3R1.	Quercetin	16-25	phosphoinositide-3-kinase regulatory subunit 1	Rattus norvegicus	165-171
34601070-7	2021	RESULTS: The lowest effective CYP3A4 inhibitory concentrations were observed for curcumin (75microM and 100 microM), quercetin (75 and 100 microM) and glycyrrhizic acid (50 microM) while the most effective p-glycoprotein (P-gp) inhibition concentrations were curcumin (10, 15, 25, 50, 75 and 100 microM), sinomenine (50, 75, and 100 microM), quercetin (75 and 100 microM) and naringin (50 microM).	Quercetin	117-126	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
34601070-7	2021	RESULTS: The lowest effective CYP3A4 inhibitory concentrations were observed for curcumin (75microM and 100 microM), quercetin (75 and 100 microM) and glycyrrhizic acid (50 microM) while the most effective p-glycoprotein (P-gp) inhibition concentrations were curcumin (10, 15, 25, 50, 75 and 100 microM), sinomenine (50, 75, and 100 microM), quercetin (75 and 100 microM) and naringin (50 microM).	Quercetin	342-351	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
34601070-9	2021	CONCLUSION: Incorporation of the drug absorption enhancers (e.g., curcumin and quercetin), at specific concentrations, in dosage forms could improve the bioavailability of the BCS Class III and IV drugs that are substrates of CYP3A4 and p-glycoprotein.	Quercetin	79-88	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	226-232
34601070-9	2021	CONCLUSION: Incorporation of the drug absorption enhancers (e.g., curcumin and quercetin), at specific concentrations, in dosage forms could improve the bioavailability of the BCS Class III and IV drugs that are substrates of CYP3A4 and p-glycoprotein.	Quercetin	79-88	ATP binding cassette subfamily B member 1	Homo sapiens	237-251
34534374-12	2021	Resveratrol-quercetin administration reduced the inflammatory process in apical periodontitis, periapical bone resorption, and altered the OPG, IL-10, and TRAP expression compared to Control and Alcohol groups.	Quercetin	12-21	TNF receptor superfamily member 11B	Rattus norvegicus	139-142
34534374-12	2021	Resveratrol-quercetin administration reduced the inflammatory process in apical periodontitis, periapical bone resorption, and altered the OPG, IL-10, and TRAP expression compared to Control and Alcohol groups.	Quercetin	12-21	interleukin 10	Rattus norvegicus	144-149
34534374-12	2021	Resveratrol-quercetin administration reduced the inflammatory process in apical periodontitis, periapical bone resorption, and altered the OPG, IL-10, and TRAP expression compared to Control and Alcohol groups.	Quercetin	12-21	tudor domain containing 7	Rattus norvegicus	155-159
34448661-9	2021	Further investigation revealed that quercetin decreased SNHG7 and elevated miR-34a-5p levels in NSCLC cells (p < .05).	Quercetin	36-45	small nucleolar RNA host gene 7	Mus musculus	56-61
34448661-12	2021	The therapeutic effect of quercetin on NSCLC cells was counteracted by co-transfection of SNHG7 mimic or miR-34a-5p inhibitor.	Quercetin	26-35	small nucleolar RNA host gene 7	Mus musculus	90-95
34448661-15	2021	CONCLUSIONS: Quercetin inhibits the proliferation and induces apoptosis of NSCLC cells by mediating signaling via the lncRNA SNHG7/miR-34a-5p pathway.	Quercetin	13-22	small nucleolar RNA host gene 7	Mus musculus	125-130
34656066-0	2021	Quercetin improves atrial fibrillation through inhibiting TGF-beta/Smads pathway via promoting MiR-135b expression.	Quercetin	0-9	transforming growth factor alpha	Rattus norvegicus	58-66
34607208-6	2021	Quercetin derivatives (CMP-4, CMP-5, CMP-6 and CMP-7) were found highly stable in the active domain of NRP1, ACE2 and Spike protein.	Quercetin	0-9	neuropilin 1	Homo sapiens	103-107
34607208-6	2021	Quercetin derivatives (CMP-4, CMP-5, CMP-6 and CMP-7) were found highly stable in the active domain of NRP1, ACE2 and Spike protein.	Quercetin	0-9	angiotensin converting enzyme 2	Homo sapiens	109-113
34607208-6	2021	Quercetin derivatives (CMP-4, CMP-5, CMP-6 and CMP-7) were found highly stable in the active domain of NRP1, ACE2 and Spike protein.	Quercetin	0-9	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	118-123
34857306-0	2021	Quercetin loaded liposomes modified with galactosylated chitosan prevent LPS/D-GalN induced acute liver injury.	Quercetin	0-9	galanin and GMAP prepropeptide	Mus musculus	79-83
34885887-3	2021	Through the in vitro XOD inhibitory assay, we obtained a novel XOD inhibitor, 5-O-caffeoylshikimic acid (#1, 5OCSA) with IC50 of 13.96 muM, as well as two known XOD inhibitors, quercetin (#3) and astilbin (#6).	Quercetin	177-186	xanthine dehydrogenase	Mus musculus	21-24
34554409-0	2021	Quercetin Exhibits alpha7nAChR/Nrf2/HO-1-Mediated Neuroprotection Against STZ-Induced Mitochondrial Toxicity and Cognitive Impairments in Experimental Rodents.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	31-35
34554409-0	2021	Quercetin Exhibits alpha7nAChR/Nrf2/HO-1-Mediated Neuroprotection Against STZ-Induced Mitochondrial Toxicity and Cognitive Impairments in Experimental Rodents.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	36-40
34554409-5	2021	Quercetin significantly mitigated the STZ-induced increase in cholinergic dysfunction, such as the increase in acetylcholinesterase activity, decrease in acetylcholine level, and activity of choline acetyltransferase, and increase in amyloid-beta aggregation and mitochondrial toxicity in respect of mitochondrial bioenergetics, integrity, and oxidative stress in memory-challenged rat hippocampus, prefrontal cortex and, amygdala.	Quercetin	0-9	acetylcholinesterase	Rattus norvegicus	111-131
34554409-5	2021	Quercetin significantly mitigated the STZ-induced increase in cholinergic dysfunction, such as the increase in acetylcholinesterase activity, decrease in acetylcholine level, and activity of choline acetyltransferase, and increase in amyloid-beta aggregation and mitochondrial toxicity in respect of mitochondrial bioenergetics, integrity, and oxidative stress in memory-challenged rat hippocampus, prefrontal cortex and, amygdala.	Quercetin	0-9	choline O-acetyltransferase	Rattus norvegicus	191-216
34554409-6	2021	Further, Quercetin significantly attenuated STZ-induced reduction in the alpha7nAChRs and HO-1 expression levels in the selected rat brain regions.	Quercetin	9-18	heme oxygenase 1	Rattus norvegicus	90-94
34554409-10	2021	Hence, Quercetin exhibits alpha7nAChR/Nrf2/HO-1-mediated neuroprotection against STZ-challenged AD-like animals.	Quercetin	7-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-42
34554409-10	2021	Hence, Quercetin exhibits alpha7nAChR/Nrf2/HO-1-mediated neuroprotection against STZ-challenged AD-like animals.	Quercetin	7-16	heme oxygenase 1	Rattus norvegicus	43-47
34656066-10	2021	Through inhibiting TGF-beta/Smads pathway via promoting miR-135b expression, quercetin treatment inhibited proliferation, myofibroblast differentiation and collagen deposition in ISO-treated RCFs, as evidenced by reduced expressions of cyclin D1, alpha-SMA, collagen-related genes and proteins, and alleviated fibrosis and collagen deposition of atrial tissues in ISO-treated rats.	Quercetin	77-86	transforming growth factor alpha	Rattus norvegicus	19-27
34656066-10	2021	Through inhibiting TGF-beta/Smads pathway via promoting miR-135b expression, quercetin treatment inhibited proliferation, myofibroblast differentiation and collagen deposition in ISO-treated RCFs, as evidenced by reduced expressions of cyclin D1, alpha-SMA, collagen-related genes and proteins, and alleviated fibrosis and collagen deposition of atrial tissues in ISO-treated rats.	Quercetin	77-86	microRNA 135b	Rattus norvegicus	56-64
34656066-10	2021	Through inhibiting TGF-beta/Smads pathway via promoting miR-135b expression, quercetin treatment inhibited proliferation, myofibroblast differentiation and collagen deposition in ISO-treated RCFs, as evidenced by reduced expressions of cyclin D1, alpha-SMA, collagen-related genes and proteins, and alleviated fibrosis and collagen deposition of atrial tissues in ISO-treated rats.	Quercetin	77-86	cyclin D1	Rattus norvegicus	236-245
34656066-10	2021	Through inhibiting TGF-beta/Smads pathway via promoting miR-135b expression, quercetin treatment inhibited proliferation, myofibroblast differentiation and collagen deposition in ISO-treated RCFs, as evidenced by reduced expressions of cyclin D1, alpha-SMA, collagen-related genes and proteins, and alleviated fibrosis and collagen deposition of atrial tissues in ISO-treated rats.	Quercetin	77-86	actin alpha 1, skeletal muscle	Homo sapiens	247-256
34656066-11	2021	CONCLUSION: Quercetin may alleviate AF by inhibiting fibrosis of atrial tissues through inhibiting TGF-beta/Smads pathway via promoting miR-135b expression.	Quercetin	12-21	transforming growth factor alpha	Rattus norvegicus	99-107
34656066-11	2021	CONCLUSION: Quercetin may alleviate AF by inhibiting fibrosis of atrial tissues through inhibiting TGF-beta/Smads pathway via promoting miR-135b expression.	Quercetin	12-21	microRNA 135b	Rattus norvegicus	136-144
34519118-1	2021	AIMS: Flavonoids and related compounds, such as quercetin-based antiviral drug Gene-Eden-VIR/Novirin, inhibit the protease of severe acute respiratory syndrome coronavirus (SARS-CoV-2).	Quercetin	48-57	novirin	None	93-100
34717121-11	2021	Generally, the results showed that separately or as a combination, supplemental quercetin and vitamin E significantly improved performance and egg quality (P < 0.05), and significantly increased serum immunoglobulins (IgA, IgM, and IgG) and cytokines (IFN-gamma and IL-2) concentrations, as well as promoted immune organ development and index, and promoted the expression of splenic immune-related genes (IL-2 and INF-gamma) (P < 0.05), compared with the control.	Quercetin	80-89	interferon gamma	Gallus gallus	252-261
34656066-0	2021	Quercetin improves atrial fibrillation through inhibiting TGF-beta/Smads pathway via promoting MiR-135b expression.	Quercetin	0-9	microRNA 135b	Rattus norvegicus	95-103
34717121-11	2021	Generally, the results showed that separately or as a combination, supplemental quercetin and vitamin E significantly improved performance and egg quality (P < 0.05), and significantly increased serum immunoglobulins (IgA, IgM, and IgG) and cytokines (IFN-gamma and IL-2) concentrations, as well as promoted immune organ development and index, and promoted the expression of splenic immune-related genes (IL-2 and INF-gamma) (P < 0.05), compared with the control.	Quercetin	80-89	interleukin 15	Gallus gallus	266-270
34717121-11	2021	Generally, the results showed that separately or as a combination, supplemental quercetin and vitamin E significantly improved performance and egg quality (P < 0.05), and significantly increased serum immunoglobulins (IgA, IgM, and IgG) and cytokines (IFN-gamma and IL-2) concentrations, as well as promoted immune organ development and index, and promoted the expression of splenic immune-related genes (IL-2 and INF-gamma) (P < 0.05), compared with the control.	Quercetin	80-89	interleukin 15	Gallus gallus	405-409
34748891-7	2021	Additionally, quercetin attenuated CYP-induced reduction in antioxidant enzyme activities and enhanced hepatic-renal function markers, namely aspartate aminotransferase (AST), alanine aminotransferase (ALT), Alkaline phosphatase (ALP), and levels of urea and creatinine.	Quercetin	14-23	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	142-168
34853352-6	2021	Besides, quercetin treatment decreased miR-155-5p expression in both models, with down-regulation of p65 and a trend toward an up-regulation of SIRT-1 in complete cell extracts.	Quercetin	9-18	microRNA 155	Homo sapiens	39-46
34853352-6	2021	Besides, quercetin treatment decreased miR-155-5p expression in both models, with down-regulation of p65 and a trend toward an up-regulation of SIRT-1 in complete cell extracts.	Quercetin	9-18	RELA proto-oncogene, NF-kB subunit	Homo sapiens	101-104
34853352-6	2021	Besides, quercetin treatment decreased miR-155-5p expression in both models, with down-regulation of p65 and a trend toward an up-regulation of SIRT-1 in complete cell extracts.	Quercetin	9-18	sirtuin 1	Homo sapiens	144-150
34853352-8	2021	The downregulation of miRNA-155-5p, possibly through the modulation of NF-kappaB and SIRT-1, could have a key role in the effects of quercetin on both pre-adipocytes and adipocytes.	Quercetin	133-142	microRNA 155	Homo sapiens	22-31
34853352-8	2021	The downregulation of miRNA-155-5p, possibly through the modulation of NF-kappaB and SIRT-1, could have a key role in the effects of quercetin on both pre-adipocytes and adipocytes.	Quercetin	133-142	nuclear factor kappa B subunit 1	Homo sapiens	71-80
34853352-8	2021	The downregulation of miRNA-155-5p, possibly through the modulation of NF-kappaB and SIRT-1, could have a key role in the effects of quercetin on both pre-adipocytes and adipocytes.	Quercetin	133-142	sirtuin 1	Homo sapiens	85-91
34748891-9	2021	CYP-induced increase in the activities of immunosuppressive indoleamine 2, 3-dioxygenase (IDO) and tryptophan 2, 3-dioxygenase (TDO) in the tissues was abated in quercetin co-treated rats.	Quercetin	162-171	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	60-88
34748891-9	2021	CYP-induced increase in the activities of immunosuppressive indoleamine 2, 3-dioxygenase (IDO) and tryptophan 2, 3-dioxygenase (TDO) in the tissues was abated in quercetin co-treated rats.	Quercetin	162-171	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	90-93
34748891-9	2021	CYP-induced increase in the activities of immunosuppressive indoleamine 2, 3-dioxygenase (IDO) and tryptophan 2, 3-dioxygenase (TDO) in the tissues was abated in quercetin co-treated rats.	Quercetin	162-171	tryptophan 2,3-dioxygenase	Rattus norvegicus	99-126
34748891-9	2021	CYP-induced increase in the activities of immunosuppressive indoleamine 2, 3-dioxygenase (IDO) and tryptophan 2, 3-dioxygenase (TDO) in the tissues was abated in quercetin co-treated rats.	Quercetin	162-171	tryptophan 2,3-dioxygenase	Rattus norvegicus	128-131
34748891-10	2021	In conclusion, Quercetin ameliorated deficits in the hepatic-renal function in CYP-exposed rats by lowering the activities/expression of immunosuppressive IDO and TDO via diminution of oxidative-inflammatory stress.	Quercetin	15-24	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	155-158
34748891-10	2021	In conclusion, Quercetin ameliorated deficits in the hepatic-renal function in CYP-exposed rats by lowering the activities/expression of immunosuppressive IDO and TDO via diminution of oxidative-inflammatory stress.	Quercetin	15-24	tryptophan 2,3-dioxygenase	Rattus norvegicus	163-166
34748891-7	2021	Additionally, quercetin attenuated CYP-induced reduction in antioxidant enzyme activities and enhanced hepatic-renal function markers, namely aspartate aminotransferase (AST), alanine aminotransferase (ALT), Alkaline phosphatase (ALP), and levels of urea and creatinine.	Quercetin	14-23	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	170-173
34748891-8	2021	Quercetin efficiently mitigated CYP-mediated increase in myeloperoxidase (MPO) activity, levels of nitric oxide and interleukin-6 (IL-6) in liver and kidney of rats.	Quercetin	0-9	myeloperoxidase	Rattus norvegicus	57-72
34748891-8	2021	Quercetin efficiently mitigated CYP-mediated increase in myeloperoxidase (MPO) activity, levels of nitric oxide and interleukin-6 (IL-6) in liver and kidney of rats.	Quercetin	0-9	myeloperoxidase	Rattus norvegicus	74-77
34748891-8	2021	Quercetin efficiently mitigated CYP-mediated increase in myeloperoxidase (MPO) activity, levels of nitric oxide and interleukin-6 (IL-6) in liver and kidney of rats.	Quercetin	0-9	interleukin 6	Rattus norvegicus	116-129
34748891-8	2021	Quercetin efficiently mitigated CYP-mediated increase in myeloperoxidase (MPO) activity, levels of nitric oxide and interleukin-6 (IL-6) in liver and kidney of rats.	Quercetin	0-9	interleukin 6	Rattus norvegicus	131-135
34862093-14	2021	Besides, E. angustifolia extract and quercetin significantly reduced the serum MMP-3 and MMP-13 concentrations.	Quercetin	37-46	matrix metallopeptidase 13	Mus musculus	89-95
34517028-5	2021	For quercetin, the encapsulation efficiency and the loading efficiency of the drug in Fe2O3-CS-MMT@QC were found to be about 94% and 57%, respectively.	Quercetin	4-13	citrate synthase	Homo sapiens	92-94
34873406-0	2021	Quercetin Improves Mitochondrial Function and Inflammation in H2O2-Induced Oxidative Stress Damage in the Gastric Mucosal Epithelial Cell by Regulating the PI3K/AKT Signaling Pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	161-164
34873406-12	2021	In conclusion, the current study demonstrates that Que alleviates oxidative stress damage in GES-1 cells by improving mitochondrial function and mucosal barrier and suppressing inflammation through regulating the PI3K/AKT signaling pathway, indicating the potential therapeutic effects of Que on FD.	Quercetin	51-54	AKT serine/threonine kinase 1	Homo sapiens	218-221
34873406-12	2021	In conclusion, the current study demonstrates that Que alleviates oxidative stress damage in GES-1 cells by improving mitochondrial function and mucosal barrier and suppressing inflammation through regulating the PI3K/AKT signaling pathway, indicating the potential therapeutic effects of Que on FD.	Quercetin	289-292	AKT serine/threonine kinase 1	Homo sapiens	218-221
34899728-7	2021	In vitro, Quercetin diminished inflammatory cytokine production through modulating NF-kappaB:A20 axis in human macrophages following challenge with oral bacteria and TLR agonists.	Quercetin	10-19	nuclear factor kappa B subunit 1	Homo sapiens	83-92
34899728-7	2021	In vitro, Quercetin diminished inflammatory cytokine production through modulating NF-kappaB:A20 axis in human macrophages following challenge with oral bacteria and TLR agonists.	Quercetin	10-19	immunoglobulin kappa variable 1-27	Homo sapiens	93-96
34873428-0	2021	Quercetin Prevents Radiation-Induced Oral Mucositis by Upregulating BMI-1.	Quercetin	0-9	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	68-73
34873428-6	2021	Quercetin pretreatment alleviated reactive oxygen species generation, NF-kappaB pathway activation, and downstream proinflammatory cytokine production and reduced DNA double-strand breaks and cellular senescence induced by ionizing radiation.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	70-79
34873428-7	2021	Quercetin also upregulated BMI-1 expression in oral epithelial cells and promoted ulcer repair.	Quercetin	0-9	Bmi1 polycomb ring finger oncogene	Mus musculus	27-32
34873428-8	2021	In addition, quercetin exerted similar radioprotective effects in irradiated primary cultured normal human keratinocytes, reduced reactive oxygen species generation and proinflammatory cytokine release, and promoted DNA double-strand break repair and wound healing by upregulating the expression of BMI-1, which is a polycomb group protein.	Quercetin	13-22	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	299-304
34873428-9	2021	Thus, quercetin can block multiple pathological processes of radiation-induced oral mucositis by targeting BMI-1 and may be a potential treatment option for preventing radiation-induced oral mucositis.	Quercetin	6-15	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	107-112
34827205-14	2021	Resveratrol and quercetin enhanced the expression of PPARgamma, and luteolin suppressed the expression of COX-1.	Quercetin	16-25	peroxisome proliferator activated receptor gamma	Homo sapiens	53-62
34821532-9	2021	Quercetin binding to Mpro altered the thermostability of the viral protein through redox-based mechanism and inhibited the viral enzymatic activity.	Quercetin	0-9	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	21-25
34821532-10	2021	Interaction of quercetin-derivatives with the Mpro seem to be influenced by the 7-OH group and the acetoxylation of sugar moiety on the ligand molecule.	Quercetin	15-24	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	46-50
34824300-5	2021	A protein functional module with best score was obtained from the PPI network using CytoHubba, and 6 high-probability quercetin targets (AKT1, JUN, MAPK, TNF, VEGFA, and EGFR) were confirmed by docking simulations.	Quercetin	118-127	AKT serine/threonine kinase 1	Homo sapiens	137-141
34824300-5	2021	A protein functional module with best score was obtained from the PPI network using CytoHubba, and 6 high-probability quercetin targets (AKT1, JUN, MAPK, TNF, VEGFA, and EGFR) were confirmed by docking simulations.	Quercetin	118-127	tumor necrosis factor	Homo sapiens	154-157
34824300-5	2021	A protein functional module with best score was obtained from the PPI network using CytoHubba, and 6 high-probability quercetin targets (AKT1, JUN, MAPK, TNF, VEGFA, and EGFR) were confirmed by docking simulations.	Quercetin	118-127	vascular endothelial growth factor A	Homo sapiens	159-164
34824300-5	2021	A protein functional module with best score was obtained from the PPI network using CytoHubba, and 6 high-probability quercetin targets (AKT1, JUN, MAPK, TNF, VEGFA, and EGFR) were confirmed by docking simulations.	Quercetin	118-127	epidermal growth factor receptor	Homo sapiens	170-174
34942962-6	2021	Additionally, we discussed the phytochemicals like curcumin, quercetin, resveratrol, epigallocatechin gallate, apigenin, sulforaphane, and ursolic acid that have effectively modified NRF2 signaling and prevented various diseases in both in vitro and in vivo models.	Quercetin	61-70	NFE2 like bZIP transcription factor 2	Homo sapiens	183-187
34959273-0	2021	Negligible Effect of Quercetin in the Pharmacokinetics of Sulfasalazine in Rats and Beagles: Metabolic Inactivation of the Interaction Potential of Quercetin with BCRP.	Quercetin	148-157	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	163-167
34959273-2	2021	This study evaluated the potential of quercetin to inhibit and induce BCRP in vitro and in vivo.	Quercetin	38-47	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	70-74
34959273-3	2021	The inhibition of BCRP was investigated for quercetin and its metabolites using BCRP/mBcrp1-overexpressing MDCKII cells by flow cytometry.	Quercetin	44-53	ATP binding cassette subfamily G member 2	Canis lupus familiaris	18-22
34959273-3	2021	The inhibition of BCRP was investigated for quercetin and its metabolites using BCRP/mBcrp1-overexpressing MDCKII cells by flow cytometry.	Quercetin	44-53	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	85-91
34959273-7	2021	Although the induction effect of quercetin on BCRP was observed in vitro, the in vivo expression of rat BCRP was not changed by multiple quercetin administrations.	Quercetin	33-42	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	46-50
34959273-10	2021	These results suggest that the in vivo drug interaction caused by quercetin via BCRP was negligible, and it may be related to the metabolic inactivation of quercetin for the inhibition of BCRP.	Quercetin	66-75	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	80-84
34959273-10	2021	These results suggest that the in vivo drug interaction caused by quercetin via BCRP was negligible, and it may be related to the metabolic inactivation of quercetin for the inhibition of BCRP.	Quercetin	66-75	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	188-192
34959273-10	2021	These results suggest that the in vivo drug interaction caused by quercetin via BCRP was negligible, and it may be related to the metabolic inactivation of quercetin for the inhibition of BCRP.	Quercetin	156-165	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	188-192
34825407-0	2022	Computational and in vitro validation of cardiogenic induction of quercetin on adipose-derived mesenchymal stromal cells through the inhibition of Wnt and non-Smad-dependent TGF-beta pathways.	Quercetin	66-75	transforming growth factor alpha	Homo sapiens	174-182
34825407-7	2022	It was found that quercetin, a p38MAPK inhibitor with the high energy dock to the active pocket of Wnt receptors, promotes cardiac differentiation via the inhibition of both Wnt and non-Smad TGF-beta pathways.	Quercetin	18-27	transforming growth factor alpha	Homo sapiens	191-199
34563617-0	2021	LIPID NANOCARRIER OF SELEGILINE AUGMENTED ANTI-PARKINSON"S EFFECT VIA P-GP MODULATION USING QUERCETIN.	Quercetin	92-101	phosphoglycolate phosphatase	Rattus norvegicus	70-74
34563617-1	2021	In the present study, SEL was loaded in a lipid nanocarrier (LNC) formulation with a P-gp pump inhibitor i.e., Quercetin (QUR) for improving the bioavailability of the SEL in the brain via the oral route.	Quercetin	111-120	phosphoglycolate phosphatase	Rattus norvegicus	85-89
34834864-2	2021	Recently, flavonol quercetin gained great attention in the light of the COVID-19 pandemic because, in addition to the anti-inflammatory, antiviral and anti-cancer activity already described, it emerged as possible inhibitor of 3CLpro, the major protease of SARS-CoV-2 virus.	Quercetin	19-28	clpro	None	228-233
34537230-0	2021	Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer"s disease rat model.	Quercetin	0-9	ADAM metallopeptidase domain 10	Rattus norvegicus	69-75
34828017-6	2021	The expression levels of apoptotic genes or proteins in either pro-apoptosis (CASP3 and FAS) or anti-apoptosis (BCL2, BCL2L1, and CFLAR) were significantly manipulated by the effects of either quercetin or curcumin.	Quercetin	193-202	caspase 3	Bos taurus	78-83
34828017-6	2021	The expression levels of apoptotic genes or proteins in either pro-apoptosis (CASP3 and FAS) or anti-apoptosis (BCL2, BCL2L1, and CFLAR) were significantly manipulated by the effects of either quercetin or curcumin.	Quercetin	193-202	BCL2 apoptosis regulator	Bos taurus	112-116
34828017-6	2021	The expression levels of apoptotic genes or proteins in either pro-apoptosis (CASP3 and FAS) or anti-apoptosis (BCL2, BCL2L1, and CFLAR) were significantly manipulated by the effects of either quercetin or curcumin.	Quercetin	193-202	BCL2 like 1	Bos taurus	118-124
34828017-6	2021	The expression levels of apoptotic genes or proteins in either pro-apoptosis (CASP3 and FAS) or anti-apoptosis (BCL2, BCL2L1, and CFLAR) were significantly manipulated by the effects of either quercetin or curcumin.	Quercetin	193-202	CASP8 and FADD like apoptosis regulator	Bos taurus	130-135
34789244-10	2021	Moreover, apart from improving the morphological injuries in the hippocampus, treatment with QUE could increase the decreased plasma concentration and hippocampal protein expression of TREM1 in NAFLD rats and increase the decreased expression of Syn-1 and Syt-1 in the hippocampus.	Quercetin	93-96	triggering receptor expressed on myeloid cells 1	Rattus norvegicus	185-190
34789244-10	2021	Moreover, apart from improving the morphological injuries in the hippocampus, treatment with QUE could increase the decreased plasma concentration and hippocampal protein expression of TREM1 in NAFLD rats and increase the decreased expression of Syn-1 and Syt-1 in the hippocampus.	Quercetin	93-96	synapsin I	Rattus norvegicus	246-251
34314805-10	2021	Furthermore, EAS, quercetin, 6-methoxykaempferol and kaempferol increase significantly (p < 0.05) SIRT1 (3.43, 1.18, 2.62 and 1.72 expression quantity, respectively) and SIRT3 (16.27, 5.01, 3.01 and 6.18 expression quantity, respectively) in HaCaT cell.	Quercetin	18-27	sirtuin 1	Homo sapiens	98-103
34314805-10	2021	Furthermore, EAS, quercetin, 6-methoxykaempferol and kaempferol increase significantly (p < 0.05) SIRT1 (3.43, 1.18, 2.62 and 1.72 expression quantity, respectively) and SIRT3 (16.27, 5.01, 3.01 and 6.18 expression quantity, respectively) in HaCaT cell.	Quercetin	18-27	sirtuin 3	Homo sapiens	170-175
34791735-6	2022	Results showed that quercetin could reduce LPS-induced C28/I2 cell apoptosis, extracellular matrix (ECM) degradation, and cell pyroptosis, and overexpression of nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family, pyrin domain-containing 3 (NLRP3) revealed that quercetin reduced chondrocyte apoptosis and ECM degradation by inhibiting NLRP3-mediated pyroptosis.	Quercetin	20-29	NLR family pyrin domain containing 3	Homo sapiens	263-268
34791735-6	2022	Results showed that quercetin could reduce LPS-induced C28/I2 cell apoptosis, extracellular matrix (ECM) degradation, and cell pyroptosis, and overexpression of nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family, pyrin domain-containing 3 (NLRP3) revealed that quercetin reduced chondrocyte apoptosis and ECM degradation by inhibiting NLRP3-mediated pyroptosis.	Quercetin	20-29	NLR family pyrin domain containing 3	Homo sapiens	358-363
34791735-6	2022	Results showed that quercetin could reduce LPS-induced C28/I2 cell apoptosis, extracellular matrix (ECM) degradation, and cell pyroptosis, and overexpression of nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family, pyrin domain-containing 3 (NLRP3) revealed that quercetin reduced chondrocyte apoptosis and ECM degradation by inhibiting NLRP3-mediated pyroptosis.	Quercetin	284-293	NLR family pyrin domain containing 3	Homo sapiens	263-268
34791735-6	2022	Results showed that quercetin could reduce LPS-induced C28/I2 cell apoptosis, extracellular matrix (ECM) degradation, and cell pyroptosis, and overexpression of nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family, pyrin domain-containing 3 (NLRP3) revealed that quercetin reduced chondrocyte apoptosis and ECM degradation by inhibiting NLRP3-mediated pyroptosis.	Quercetin	284-293	NLR family pyrin domain containing 3	Homo sapiens	358-363
34791735-7	2022	Furthermore, quercetin could reduce chondrocyte apoptosis and ECM degradation, and inhibit NLRP3-mediated pyroptosis through blocking oxidative stress.	Quercetin	13-22	NLR family pyrin domain containing 3	Homo sapiens	91-96
34834040-0	2021	Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells.	Quercetin	0-9	cytochrome b-245 beta chain	Homo sapiens	79-83
34834040-4	2021	The lipopolysaccharide (LPS)-induced elevation of intracellular ROS levels was reduced after quercetin treatment, which also almost completely abolished the mRNA and protein expression of nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) induced by LPS stimulation.	Quercetin	93-102	cytochrome b-245 beta chain	Homo sapiens	188-241
34834040-4	2021	The lipopolysaccharide (LPS)-induced elevation of intracellular ROS levels was reduced after quercetin treatment, which also almost completely abolished the mRNA and protein expression of nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) induced by LPS stimulation.	Quercetin	93-102	cytochrome b-245 beta chain	Homo sapiens	243-247
34834040-5	2021	In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-kappaB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure.	Quercetin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	63-85
34834040-5	2021	In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-kappaB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure.	Quercetin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	87-96
34834040-5	2021	In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-kappaB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure.	Quercetin	13-22	tumor necrosis factor	Homo sapiens	142-175
34834040-5	2021	In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-kappaB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure.	Quercetin	13-22	interleukin 1 alpha	Homo sapiens	177-195
34834040-5	2021	In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-kappaB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure.	Quercetin	13-22	interleukin 6	Homo sapiens	201-205
34834040-6	2021	Our data demonstrated that quercetin decreased ROS-induced oxidative stress and inflammation by suppressing NOX2 production.	Quercetin	27-36	cytochrome b-245 beta chain	Homo sapiens	108-112
34537230-0	2021	Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer"s disease rat model.	Quercetin	0-9	ADAM metallopeptidase domain 17	Rattus norvegicus	80-86
34537230-7	2021	KEY FINDINGS: Administration of Q to AlCl3-induced AD rat model attenuated behavioral deficits, improved cholinergic and dopaminergic dysfunctions, and diminished insoluble amyloid beta (Abeta) plaques aggregation in the hippocampus.	Quercetin	32-33	amyloid beta precursor protein	Rattus norvegicus	187-192
34537230-8	2021	These ameliorative effects of Q were associated with down-regulation of APP, BACE1, APH1, and PSEN1 and up-regulation of ADAM10 and ADAM17 gene expression levels in the hippocampus.	Quercetin	30-31	beta-secretase 1	Rattus norvegicus	77-82
34537230-8	2021	These ameliorative effects of Q were associated with down-regulation of APP, BACE1, APH1, and PSEN1 and up-regulation of ADAM10 and ADAM17 gene expression levels in the hippocampus.	Quercetin	30-31	presenilin 1	Rattus norvegicus	94-99
34537230-8	2021	These ameliorative effects of Q were associated with down-regulation of APP, BACE1, APH1, and PSEN1 and up-regulation of ADAM10 and ADAM17 gene expression levels in the hippocampus.	Quercetin	30-31	ADAM metallopeptidase domain 10	Rattus norvegicus	121-127
34537230-8	2021	These ameliorative effects of Q were associated with down-regulation of APP, BACE1, APH1, and PSEN1 and up-regulation of ADAM10 and ADAM17 gene expression levels in the hippocampus.	Quercetin	30-31	ADAM metallopeptidase domain 17	Rattus norvegicus	132-138
34537230-9	2021	SIGNIFICANCE: The present study suggests that Q might attenuate neurotransmission impairment, Abeta aggregation in the hippocampus, and behavioral deficits in the AlCl3-induce AD rat model via up-regulating ADAM 10 and ADAM 17 (alpha-secretase) gene expression, leading to the inhibition of the amyloidogenic pathway.	Quercetin	46-47	ADAM metallopeptidase domain 10	Rattus norvegicus	207-214
34537230-9	2021	SIGNIFICANCE: The present study suggests that Q might attenuate neurotransmission impairment, Abeta aggregation in the hippocampus, and behavioral deficits in the AlCl3-induce AD rat model via up-regulating ADAM 10 and ADAM 17 (alpha-secretase) gene expression, leading to the inhibition of the amyloidogenic pathway.	Quercetin	46-47	ADAM metallopeptidase domain 17	Rattus norvegicus	219-226
34829892-0	2021	Mitochondria-Mediated Apoptosis of HCC Cells Triggered by Knockdown of Glutamate Dehydrogenase 1: Perspective for Its Inhibition through Quercetin and Permethylated Anigopreissin A.	Quercetin	137-146	glutamate dehydrogenase 1	Homo sapiens	71-96
34773179-0	2022	Quercetin and HSC70 coregulate the anti-inflammatory action of the ubiquitin-like protein MNSFbeta.	Quercetin	0-9	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	Mus musculus	90-98
34773179-4	2022	This study found that quercetin and the heat shock protein HSC70 coregulate the action of MNSFbeta.	Quercetin	22-31	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	Mus musculus	90-98
34773179-5	2022	METHODS AND RESULTS: Quercetin dose-dependently suppressed the LPS/interferon gamma-induced nitric oxide production without cytotoxicity in the macrophage-like cell line Raw264.7.	Quercetin	21-30	interferon gamma	Mus musculus	67-83
34773179-6	2022	SiRNA knockdown experiments showed that quercetin inhibited the MNSFbeta and HSC70 siRNA-mediated enhancement of TNFalpha and the production of RANTES, a member of C-C chemokine superfamily, in LPS-stimulated Raw264.7 cells.	Quercetin	40-49	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	Mus musculus	64-72
34773179-6	2022	SiRNA knockdown experiments showed that quercetin inhibited the MNSFbeta and HSC70 siRNA-mediated enhancement of TNFalpha and the production of RANTES, a member of C-C chemokine superfamily, in LPS-stimulated Raw264.7 cells.	Quercetin	40-49	heat shock protein 8	Mus musculus	77-82
34773179-6	2022	SiRNA knockdown experiments showed that quercetin inhibited the MNSFbeta and HSC70 siRNA-mediated enhancement of TNFalpha and the production of RANTES, a member of C-C chemokine superfamily, in LPS-stimulated Raw264.7 cells.	Quercetin	40-49	tumor necrosis factor	Mus musculus	113-121
34773179-6	2022	SiRNA knockdown experiments showed that quercetin inhibited the MNSFbeta and HSC70 siRNA-mediated enhancement of TNFalpha and the production of RANTES, a member of C-C chemokine superfamily, in LPS-stimulated Raw264.7 cells.	Quercetin	40-49	chemokine (C-C motif) ligand 5	Mus musculus	144-150
34773179-7	2022	Western blot analysis showed that quercetin and HSC70 regulated ERK1/2 activation and LPS-stimulated IkappaBalpha degradation by affecting the complex formation of MNSFbeta and the proapoptotic protein Bcl-G.	Quercetin	34-43	mitogen-activated protein kinase 3	Mus musculus	64-70
34773179-7	2022	Western blot analysis showed that quercetin and HSC70 regulated ERK1/2 activation and LPS-stimulated IkappaBalpha degradation by affecting the complex formation of MNSFbeta and the proapoptotic protein Bcl-G.	Quercetin	34-43	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	101-113
34773179-7	2022	Western blot analysis showed that quercetin and HSC70 regulated ERK1/2 activation and LPS-stimulated IkappaBalpha degradation by affecting the complex formation of MNSFbeta and the proapoptotic protein Bcl-G.	Quercetin	34-43	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	Mus musculus	164-172
34829892-7	2021	The inhibition strategy leads us to identify two possible inhibitors of hGDH1: quercetin and Permethylated Anigopreissin A (PAA).	Quercetin	79-88	glutamate dehydrogenase 1	Homo sapiens	72-77
34773179-7	2022	Western blot analysis showed that quercetin and HSC70 regulated ERK1/2 activation and LPS-stimulated IkappaBalpha degradation by affecting the complex formation of MNSFbeta and the proapoptotic protein Bcl-G.	Quercetin	34-43	BCL2-like 14 (apoptosis facilitator)	Mus musculus	202-207
34773179-10	2022	Quercetin may negatively control the function of MNSFbeta by regulating the action of the molecular chaperone HSC70.	Quercetin	0-9	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	Mus musculus	49-57
34858215-7	2021	KCNQ2/3 activation at physiologically relevant, subthreshold membrane potentials by tannic acid, gallic acid and quercetin provided molecular correlates for analgesic action of several of the plants.	Quercetin	113-122	potassium voltage-gated channel, subfamily Q, member 2	Mus musculus	0-7
34829893-6	2021	Pre-exposure to AOX1 alone or in combination with AF4, Q, or Q3G before challenging with NNKOAc and MTX significantly reduced intracellular reactive oxygen species (ROS) levels and DNA damage in BEAS-2B cells.	Quercetin	55-56	aldehyde oxidase 1	Homo sapiens	16-20
34773179-10	2022	Quercetin may negatively control the function of MNSFbeta by regulating the action of the molecular chaperone HSC70.	Quercetin	0-9	heat shock protein 8	Mus musculus	110-115
34805114-6	2021	Kaempferol, quercetin, and catechin were found to have the highest binding affinity with the synaptic vesicle 2A (SV2A) protein, comparable to standard levetiracetam (LEV).	Quercetin	12-21	synaptic vesicle glycoprotein 2a	Rattus norvegicus	93-112
34558606-0	2021	Quercetin inhibits the proliferation of multiple myeloma cells by upregulating PTPRR expression.	Quercetin	0-9	protein tyrosine phosphatase receptor type R	Homo sapiens	79-84
34558606-10	2021	In summary, our study identified the gene expression profile in Que-treated MM cells and demonstrated that the upregulation of PTPRR was one of the important mechanisms for the Que-induced inhibition of MM cell proliferation.	Quercetin	177-180	protein tyrosine phosphatase receptor type R	Homo sapiens	127-132
34805114-6	2021	Kaempferol, quercetin, and catechin were found to have the highest binding affinity with the synaptic vesicle 2A (SV2A) protein, comparable to standard levetiracetam (LEV).	Quercetin	12-21	synaptic vesicle glycoprotein 2a	Rattus norvegicus	114-118
34803913-0	2021	Quercetin Modulates IGF-I and IGF-II Levels After Eccentric Exercise-Induced Muscle-Damage: A Placebo-Controlled Study.	Quercetin	0-9	insulin like growth factor 1	Homo sapiens	20-25
34803913-0	2021	Quercetin Modulates IGF-I and IGF-II Levels After Eccentric Exercise-Induced Muscle-Damage: A Placebo-Controlled Study.	Quercetin	0-9	insulin like growth factor 2	Homo sapiens	30-36
34129156-0	2021	Quercetin improves oxidative stress-induced pancreatic beta cell alterations via mTOR-signaling.	Quercetin	0-9	mechanistic target of rapamycin kinase	Mus musculus	81-85
34803913-2	2021	Objectives: The aim of the present investigation was to evaluate, in humans, the effect of the flavonoid quercetin on circulating levels of the anabolic insulin-like growth factor 1 (IGF-I) and insulin-like growth factor 2 (IGF-II), produced during the recovery period after an eccentric-induced muscle damage (EIMD).	Quercetin	105-114	insulin like growth factor 1	Homo sapiens	153-181
34803913-2	2021	Objectives: The aim of the present investigation was to evaluate, in humans, the effect of the flavonoid quercetin on circulating levels of the anabolic insulin-like growth factor 1 (IGF-I) and insulin-like growth factor 2 (IGF-II), produced during the recovery period after an eccentric-induced muscle damage (EIMD).	Quercetin	105-114	insulin like growth factor 1	Homo sapiens	183-188
34803913-2	2021	Objectives: The aim of the present investigation was to evaluate, in humans, the effect of the flavonoid quercetin on circulating levels of the anabolic insulin-like growth factor 1 (IGF-I) and insulin-like growth factor 2 (IGF-II), produced during the recovery period after an eccentric-induced muscle damage (EIMD).	Quercetin	105-114	insulin like growth factor 2	Homo sapiens	194-222
34803913-2	2021	Objectives: The aim of the present investigation was to evaluate, in humans, the effect of the flavonoid quercetin on circulating levels of the anabolic insulin-like growth factor 1 (IGF-I) and insulin-like growth factor 2 (IGF-II), produced during the recovery period after an eccentric-induced muscle damage (EIMD).	Quercetin	105-114	insulin like growth factor 2	Homo sapiens	224-230
34803913-7	2021	Quercetin significantly reduced plasma markers of cell damage (CK (p<0.005), LDH (p<0.001) and Mb (p<0.05)) and the interleukin 6 level (IL-6 (p<0.05)) during recovery period following EIMD compared to placebo.	Quercetin	0-9	interleukin 6	Homo sapiens	116-129
34803913-7	2021	Quercetin significantly reduced plasma markers of cell damage (CK (p<0.005), LDH (p<0.001) and Mb (p<0.05)) and the interleukin 6 level (IL-6 (p<0.05)) during recovery period following EIMD compared to placebo.	Quercetin	0-9	interleukin 6	Homo sapiens	137-141
34803913-8	2021	Conclusions: Our data are encouraging about the use of quercetin as dietary supplementation strategy to adopt in order to mitigate and promote a faster recovery after eccentric exercise as suggested by the increase in plasma levels of the anabolic factors IGF-I and IGF-II.	Quercetin	55-64	insulin like growth factor 1	Homo sapiens	256-261
34803913-8	2021	Conclusions: Our data are encouraging about the use of quercetin as dietary supplementation strategy to adopt in order to mitigate and promote a faster recovery after eccentric exercise as suggested by the increase in plasma levels of the anabolic factors IGF-I and IGF-II.	Quercetin	55-64	insulin like growth factor 2	Homo sapiens	266-272
34603528-7	2021	It was revealed that quercetin inhibited the production of inflammatory cytokines and the expression of XIST in RAFLSs induced by TNF-alpha.	Quercetin	21-30	X inactive specific transcript	Homo sapiens	104-108
34603528-7	2021	It was revealed that quercetin inhibited the production of inflammatory cytokines and the expression of XIST in RAFLSs induced by TNF-alpha.	Quercetin	21-30	tumor necrosis factor	Homo sapiens	130-139
34603528-10	2021	Overall, quercetin was observed to inhibit the production of inflammatory cytokines and the expression of XIST in RAFLSs induced by TNF-alpha.	Quercetin	9-18	X inactive specific transcript	Homo sapiens	106-110
34603528-10	2021	Overall, quercetin was observed to inhibit the production of inflammatory cytokines and the expression of XIST in RAFLSs induced by TNF-alpha.	Quercetin	9-18	tumor necrosis factor	Homo sapiens	132-141
34651301-5	2021	Furthermore, dietary quercetin supplementation significantly enhanced the glutathione peroxidase (GPx) and catalase (CAT) activities in serum, liver and gastrocnemius muscle and enhanced the total superoxide dismutase (T-SOD) activity in gastrocnemius muscle, but decreased the malondialdehyde (MDA) content and reactive oxygen species (ROS) level.	Quercetin	21-30	catalase	Mus musculus	107-115
34651301-5	2021	Furthermore, dietary quercetin supplementation significantly enhanced the glutathione peroxidase (GPx) and catalase (CAT) activities in serum, liver and gastrocnemius muscle and enhanced the total superoxide dismutase (T-SOD) activity in gastrocnemius muscle, but decreased the malondialdehyde (MDA) content and reactive oxygen species (ROS) level.	Quercetin	21-30	catalase	Mus musculus	117-120
34620029-5	2021	In the present paper, we reported the ultrastructural changes in GCTB cells exposed to quercetin and also determined the expression of RIP1K, Caspase 3 and Caspase 8 on the exposed cells.	Quercetin	87-96	caspase 3	Homo sapiens	142-151
34620029-5	2021	In the present paper, we reported the ultrastructural changes in GCTB cells exposed to quercetin and also determined the expression of RIP1K, Caspase 3 and Caspase 8 on the exposed cells.	Quercetin	87-96	caspase 8	Homo sapiens	156-165
34517138-4	2021	Dietary quercetin increased catalase (CAT), and lysozyme (LZM) activity in crayfish.	Quercetin	8-17	catalase	Homo sapiens	28-36
34517138-4	2021	Dietary quercetin increased catalase (CAT), and lysozyme (LZM) activity in crayfish.	Quercetin	8-17	catalase	Homo sapiens	38-41
34517138-4	2021	Dietary quercetin increased catalase (CAT), and lysozyme (LZM) activity in crayfish.	Quercetin	8-17	lysozyme	Homo sapiens	48-56
34517138-4	2021	Dietary quercetin increased catalase (CAT), and lysozyme (LZM) activity in crayfish.	Quercetin	8-17	lysozyme	Homo sapiens	58-61
34517138-5	2021	Dietary quercetin increased the expression of NF-kappaB, anti-lipopolysaccharide factor (ALF) and toll-like receptor (TLR) genes in crayfish.	Quercetin	8-17	nuclear factor kappa B subunit 1	Homo sapiens	46-55
34517138-5	2021	Dietary quercetin increased the expression of NF-kappaB, anti-lipopolysaccharide factor (ALF) and toll-like receptor (TLR) genes in crayfish.	Quercetin	8-17	toll-like receptor	None	98-116
34129156-6	2021	Quercetin treatment increased mitochondrial biogenesis, caused hypertrophy in pancreatic beta cells and activated mTOR signaling with a transient change in mitochondrial membrane potential and AMP/ATP.	Quercetin	0-9	mechanistic target of rapamycin kinase	Mus musculus	114-118
34539858-0	2021	EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.	Quercetin	42-51	epidermal growth factor receptor	Homo sapiens	0-4
34539858-0	2021	EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.	Quercetin	42-51	mitogen-activated protein kinase 1	Homo sapiens	9-12
34539858-2	2021	The results suggested that the natural flavonoid quercetin (Que), the effective antitumor ingredient in SH, which is widely present in a variety of plants, may depend on the target, EGFR.	Quercetin	49-58	epidermal growth factor receptor	Homo sapiens	182-186
34539858-2	2021	The results suggested that the natural flavonoid quercetin (Que), the effective antitumor ingredient in SH, which is widely present in a variety of plants, may depend on the target, EGFR.	Quercetin	60-63	epidermal growth factor receptor	Homo sapiens	182-186
34539858-8	2021	Therefore, to the best of our knowledge, the current results provided the first evidence that EGFR and ERK activation induced by Que could resist Que-induced anticancer activities.	Quercetin	129-132	epidermal growth factor receptor	Homo sapiens	94-98
34539858-8	2021	Therefore, to the best of our knowledge, the current results provided the first evidence that EGFR and ERK activation induced by Que could resist Que-induced anticancer activities.	Quercetin	129-132	mitogen-activated protein kinase 1	Homo sapiens	103-106
34539858-8	2021	Therefore, to the best of our knowledge, the current results provided the first evidence that EGFR and ERK activation induced by Que could resist Que-induced anticancer activities.	Quercetin	146-149	epidermal growth factor receptor	Homo sapiens	94-98
34539858-8	2021	Therefore, to the best of our knowledge, the current results provided the first evidence that EGFR and ERK activation induced by Que could resist Que-induced anticancer activities.	Quercetin	146-149	mitogen-activated protein kinase 1	Homo sapiens	103-106
34539858-9	2021	On this basis, the present study determined the role of EGFR and the underlying signaling pathways involved in the anti-cervical cancer malignant behavior induced by Que and identified the negative regulatory association.	Quercetin	166-169	epidermal growth factor receptor	Homo sapiens	56-60
34583226-5	2021	We found that the phytochemical compounds, such as curcumin, naringenin, sulforaphane, diallyl disulfide, mangiferin, oleanolic acid, umbelliferone, daphnetin, quercetin, isorhamnetin-3-O-galactoside, hesperidin, diammonium glycyrrhizinate, corilagin, shikonin, farrerol, and chenpi, had the potential to improve the Nrf2-ARE signaling thereby combat hepatotoxicity.	Quercetin	160-169	NFE2 like bZIP transcription factor 2	Homo sapiens	317-321
34364457-10	2021	Detection limits of 0.12, 0.28, 0.46, 0.85, and 1.23 mug mL-1 were obtained for gallic acid, quercetin, catechin, kaempferol, and caffeic acid, respectively.	Quercetin	93-102	L1 cell adhesion molecule	Mus musculus	57-61
34560814-0	2021	Quercetin inhibiting the PD-1/PD-L1 interaction for immune-enhancing cancer chemopreventive agent.	Quercetin	0-9	programmed cell death 1	Mus musculus	25-29
34560814-0	2021	Quercetin inhibiting the PD-1/PD-L1 interaction for immune-enhancing cancer chemopreventive agent.	Quercetin	0-9	CD274 antigen	Mus musculus	30-35
34411613-1	2021	In the present work, lactoferrin (Lf) based nanoparticle incorporated self-supporting gel encapsulating a flavonoid, quercetin (Q), was developed.	Quercetin	117-126	lactotransferrin	Rattus norvegicus	21-32
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	Quercetin	38-47	interleukin 6	Homo sapiens	219-222
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	Quercetin	38-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	224-229
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	Quercetin	38-47	mitogen-activated protein kinase 1	Homo sapiens	231-236
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	Quercetin	38-47	mitogen-activated protein kinase 3	Homo sapiens	238-243
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	Quercetin	38-47	calcitonin related polypeptide alpha	Homo sapiens	249-254
34627080-9	2021	PBMCs treated with LPS increased higher levels of TNF-alpha mRNA and protein, but this effect was weakened when they were co-treated with quercetin.	Quercetin	138-147	tumor necrosis factor	Homo sapiens	50-59
34627080-10	2021	These findings indicated that quercetin inhibits NET formation of PMNs by suppressing production of TNF-alpha from LPS-stimulated PBMCs.	Quercetin	30-39	tumor necrosis factor	Homo sapiens	100-109
34627080-11	2021	These results suggest that quercetin exerts an anti-inflammatory effect, mediated by down-regulation of TNF-alpha production from LPS-stimulated PBMCs, which inhibits NET formation in PMNs.	Quercetin	27-36	tumor necrosis factor	Homo sapiens	104-113
34411613-2	2021	The complex formation between Lf and Q was assessed using molecular docking and dynamics simulation that lactoferrin and quercetin showed strong interaction and binding supporting hydrophobic interaction.	Quercetin	37-38	lactotransferrin	Rattus norvegicus	105-116
34411613-1	2021	In the present work, lactoferrin (Lf) based nanoparticle incorporated self-supporting gel encapsulating a flavonoid, quercetin (Q), was developed.	Quercetin	128-129	lactotransferrin	Rattus norvegicus	21-32
34746302-16	2021	The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD.	Quercetin	36-45	AKT serine/threonine kinase 1	Homo sapiens	143-147
34746302-16	2021	The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD.	Quercetin	36-45	vascular endothelial growth factor A	Homo sapiens	149-154
34746302-16	2021	The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD.	Quercetin	36-45	interleukin 6	Homo sapiens	160-163
34776960-0	2021	Quercetin Attenuates Cardiac Hypertrophy by Inhibiting Mitochondrial Dysfunction Through SIRT3/PARP-1 Pathway.	Quercetin	0-9	sirtuin 3	Rattus norvegicus	89-94
34776960-0	2021	Quercetin Attenuates Cardiac Hypertrophy by Inhibiting Mitochondrial Dysfunction Through SIRT3/PARP-1 Pathway.	Quercetin	0-9	poly (ADP-ribose) polymerase 1	Rattus norvegicus	95-101
34776960-14	2021	Our results suggested that quercetin protected mitochondrial function by modulating SIRT3/PARP-1 pathway, contributing to the inhibition of cardiac hypertrophy.	Quercetin	27-36	sirtuin 3	Rattus norvegicus	84-89
34776960-11	2021	In vitro, Ang II increased the mRNA level of hypertrophic markers including atrial natriuretic factor (ANF) and beta-myosin heavy chain (beta-MHC), whereas quercetin ameliorated this hypertrophic response.	Quercetin	156-165	natriuretic peptide A	Rattus norvegicus	76-101
34776960-14	2021	Our results suggested that quercetin protected mitochondrial function by modulating SIRT3/PARP-1 pathway, contributing to the inhibition of cardiac hypertrophy.	Quercetin	27-36	poly (ADP-ribose) polymerase 1	Rattus norvegicus	90-96
34776960-11	2021	In vitro, Ang II increased the mRNA level of hypertrophic markers including atrial natriuretic factor (ANF) and beta-myosin heavy chain (beta-MHC), whereas quercetin ameliorated this hypertrophic response.	Quercetin	156-165	myosin heavy chain 7	Rattus norvegicus	112-135
34776960-13	2021	Importantly, mitochondrial protection and PARP-1 inhibition by quercetin were partly abolished after SIRT3 knockdown.	Quercetin	63-72	poly (ADP-ribose) polymerase 1	Rattus norvegicus	42-48
34776960-13	2021	Importantly, mitochondrial protection and PARP-1 inhibition by quercetin were partly abolished after SIRT3 knockdown.	Quercetin	63-72	sirtuin 3	Rattus norvegicus	101-106
34745273-12	2021	Molecular docking shows that flavonoids such as quercetin have better binding to the target protein Akt1.	Quercetin	48-57	AKT serine/threonine kinase 1	Homo sapiens	100-104
34829572-8	2021	Further biochemical assessment of the hind limb tissue showed decreased oxidative stress, increased levels of nitric oxide and endothelial nitric oxide synthase (eNOS), and enhancement of the levels of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) in the groups treated with methyl gallate and quercetin.	Quercetin	318-327	nitric oxide synthase 3	Rattus norvegicus	127-160
34829572-8	2021	Further biochemical assessment of the hind limb tissue showed decreased oxidative stress, increased levels of nitric oxide and endothelial nitric oxide synthase (eNOS), and enhancement of the levels of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) in the groups treated with methyl gallate and quercetin.	Quercetin	318-327	nitric oxide synthase 3	Rattus norvegicus	162-166
34829572-8	2021	Further biochemical assessment of the hind limb tissue showed decreased oxidative stress, increased levels of nitric oxide and endothelial nitric oxide synthase (eNOS), and enhancement of the levels of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) in the groups treated with methyl gallate and quercetin.	Quercetin	318-327	heme oxygenase 1	Rattus norvegicus	202-218
34829572-8	2021	Further biochemical assessment of the hind limb tissue showed decreased oxidative stress, increased levels of nitric oxide and endothelial nitric oxide synthase (eNOS), and enhancement of the levels of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) in the groups treated with methyl gallate and quercetin.	Quercetin	318-327	heme oxygenase 1	Rattus norvegicus	220-224
34829572-8	2021	Further biochemical assessment of the hind limb tissue showed decreased oxidative stress, increased levels of nitric oxide and endothelial nitric oxide synthase (eNOS), and enhancement of the levels of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) in the groups treated with methyl gallate and quercetin.	Quercetin	318-327	vascular endothelial growth factor A	Rattus norvegicus	230-264
34754366-0	2021	Quercetin Alleviates Red Bull Energy Drink-Induced Cerebral Cortex Neurotoxicity via Modulation of Nrf2 and HO-1.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	99-103
34754366-0	2021	Quercetin Alleviates Red Bull Energy Drink-Induced Cerebral Cortex Neurotoxicity via Modulation of Nrf2 and HO-1.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	108-112
34754366-9	2021	Quercetin also inhibited RB-Ed-induced histomorphological degeneration which was confirmed by the increase in the intact neurons and the rise in the neuron-specific enolase immunoreaction.	Quercetin	0-9	enolase 2	Rattus norvegicus	149-172
34829572-8	2021	Further biochemical assessment of the hind limb tissue showed decreased oxidative stress, increased levels of nitric oxide and endothelial nitric oxide synthase (eNOS), and enhancement of the levels of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) in the groups treated with methyl gallate and quercetin.	Quercetin	318-327	vascular endothelial growth factor A	Rattus norvegicus	266-270
34829572-9	2021	Expression levels of hypoxia inducible factor-1 alpha (HIF-1alpha), VEGF, fibroblast growth factor-2 (FGF-2), and miR-146a were upregulated in the muscle tissue of methyl gallate- and quercetin-treated groups along with downregulation of nuclear factor kappa B (NF-kappaB).	Quercetin	184-193	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	21-53
34829572-9	2021	Expression levels of hypoxia inducible factor-1 alpha (HIF-1alpha), VEGF, fibroblast growth factor-2 (FGF-2), and miR-146a were upregulated in the muscle tissue of methyl gallate- and quercetin-treated groups along with downregulation of nuclear factor kappa B (NF-kappaB).	Quercetin	184-193	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	55-65
34829572-9	2021	Expression levels of hypoxia inducible factor-1 alpha (HIF-1alpha), VEGF, fibroblast growth factor-2 (FGF-2), and miR-146a were upregulated in the muscle tissue of methyl gallate- and quercetin-treated groups along with downregulation of nuclear factor kappa B (NF-kappaB).	Quercetin	184-193	vascular endothelial growth factor A	Rattus norvegicus	68-72
34829572-9	2021	Expression levels of hypoxia inducible factor-1 alpha (HIF-1alpha), VEGF, fibroblast growth factor-2 (FGF-2), and miR-146a were upregulated in the muscle tissue of methyl gallate- and quercetin-treated groups along with downregulation of nuclear factor kappa B (NF-kappaB).	Quercetin	184-193	fibroblast growth factor 2	Rattus norvegicus	74-100
34829572-9	2021	Expression levels of hypoxia inducible factor-1 alpha (HIF-1alpha), VEGF, fibroblast growth factor-2 (FGF-2), and miR-146a were upregulated in the muscle tissue of methyl gallate- and quercetin-treated groups along with downregulation of nuclear factor kappa B (NF-kappaB).	Quercetin	184-193	fibroblast growth factor 2	Rattus norvegicus	102-107
34904016-0	2021	Quercetin Reduces Oxidative Stress and Apoptosis by Inhibiting HMGB1 and Its Translocation, Thereby Alleviating Liver Injury in ACLF Rats.	Quercetin	0-9	high mobility group box 1	Rattus norvegicus	63-68
34829572-9	2021	Expression levels of hypoxia inducible factor-1 alpha (HIF-1alpha), VEGF, fibroblast growth factor-2 (FGF-2), and miR-146a were upregulated in the muscle tissue of methyl gallate- and quercetin-treated groups along with downregulation of nuclear factor kappa B (NF-kappaB).	Quercetin	184-193	microRNA 146a	Rattus norvegicus	114-122
34791846-12	2021	CONCLUSIONS: The active ingredients of Kushen Decoction, such as quercetin, (+)-14alpha-hydroxymatrine and apigenin, may act on targets like AKT1, TNF, IL-6 to modulate TLR, NLR and NF-kappaB signaling pathways to play a synergistic role in the treatment of cryptosporidiosis in the hematologic and immune system.	Quercetin	65-74	AKT serine/threonine kinase 1	Homo sapiens	141-145
34791846-12	2021	CONCLUSIONS: The active ingredients of Kushen Decoction, such as quercetin, (+)-14alpha-hydroxymatrine and apigenin, may act on targets like AKT1, TNF, IL-6 to modulate TLR, NLR and NF-kappaB signaling pathways to play a synergistic role in the treatment of cryptosporidiosis in the hematologic and immune system.	Quercetin	65-74	tumor necrosis factor	Homo sapiens	147-150
34791846-12	2021	CONCLUSIONS: The active ingredients of Kushen Decoction, such as quercetin, (+)-14alpha-hydroxymatrine and apigenin, may act on targets like AKT1, TNF, IL-6 to modulate TLR, NLR and NF-kappaB signaling pathways to play a synergistic role in the treatment of cryptosporidiosis in the hematologic and immune system.	Quercetin	65-74	interleukin 6	Homo sapiens	152-156
34904016-3	2021	Our previous studies have shown that quercetin (Que) exerts anti-oxidant and anti-apoptotic effects by inhibiting HMGB1 in vitro.	Quercetin	37-46	high mobility group box 1	Rattus norvegicus	114-119
34904016-3	2021	Our previous studies have shown that quercetin (Que) exerts anti-oxidant and anti-apoptotic effects by inhibiting HMGB1 in vitro.	Quercetin	48-51	high mobility group box 1	Rattus norvegicus	114-119
34833010-8	2021	Our results indicate that quercetin can interrupt the activated caspase and mitochondrial pathway induced by indomethacin in HEK293 cells and affect apoptotic mRNA expression.	Quercetin	26-35	caspase 9	Homo sapiens	64-71
34833010-6	2021	In addition, we demonstrated the effect of quercetin on indomethacin-treated HEK293 cells by inactivating the caspase-3 and caspase-9 signals.	Quercetin	43-52	caspase 3	Homo sapiens	110-119
34833010-6	2021	In addition, we demonstrated the effect of quercetin on indomethacin-treated HEK293 cells by inactivating the caspase-3 and caspase-9 signals.	Quercetin	43-52	caspase 9	Homo sapiens	124-133
34733451-11	2021	Molecular docking showed that the active components of XJD (beta-sitosterol, kaempferol, formononetin, quercetin, and luteolin) showed good binding activities to five of the six hub gene targets.	Quercetin	103-112	ELAV like RNA binding protein 2	Homo sapiens	178-181
34733451-13	2021	The active ingredients of XJD (beta-sitosterol, kaempferol, formononetin, quercetin, and luteolin) may regulate the inflammatory and oxidative stress-related pathways of colon cells during the course of UC by binding to the hub gene targets.	Quercetin	74-83	ELAV like RNA binding protein 2	Homo sapiens	224-227
34681164-8	2021	Docking studies with the antiviral plant flavonoid Quercetin with NS3 indicated that Quercetin physically occluded the serine 137 phosphorylation site.	Quercetin	51-60	KRAS proto-oncogene, GTPase	Homo sapiens	66-69
34744717-12	2021	In addition, quercetin can also activate Keap1/Nrf2 signaling pathway, reduce ATF6/GRP78 protein expression.	Quercetin	13-22	kelch like ECH associated protein 1	Homo sapiens	41-46
34744717-12	2021	In addition, quercetin can also activate Keap1/Nrf2 signaling pathway, reduce ATF6/GRP78 protein expression.	Quercetin	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
34744717-12	2021	In addition, quercetin can also activate Keap1/Nrf2 signaling pathway, reduce ATF6/GRP78 protein expression.	Quercetin	13-22	activating transcription factor 6	Homo sapiens	78-82
34744717-12	2021	In addition, quercetin can also activate Keap1/Nrf2 signaling pathway, reduce ATF6/GRP78 protein expression.	Quercetin	13-22	heat shock protein family A (Hsp70) member 5	Homo sapiens	83-88
34744717-13	2021	Further study showed that quercetin could increase the expression of Claudin-5 and Zonula occludens-1.	Quercetin	26-35	claudin 5	Homo sapiens	69-78
34681164-0	2021	In Silico Prediction of the Phosphorylation of NS3 as an Essential Mechanism for Dengue Virus Replication and the Antiviral Activity of Quercetin.	Quercetin	136-145	KRAS proto-oncogene, GTPase	Homo sapiens	47-50
34681164-8	2021	Docking studies with the antiviral plant flavonoid Quercetin with NS3 indicated that Quercetin physically occluded the serine 137 phosphorylation site.	Quercetin	85-94	KRAS proto-oncogene, GTPase	Homo sapiens	66-69
34469746-8	2021	This method was successfully applied to quantify the uptake of GLUT1-mediated 2-NBDG, and the results clearly indicated inhibition of GLUT1 by WZB117 and quercetin (two potent glucose transporter inhibitors) in the GLUT1-HEK293T cell model.	Quercetin	154-163	solute carrier family 2 member 1	Homo sapiens	63-68
34116327-7	2021	Enzymatic assays revealed that the selected derivatives were superior to the reference MMP-9 and MAO-A inhibitors (quercetin and clorgyline, respectively).	Quercetin	115-124	matrix metallopeptidase 9	Homo sapiens	87-92
34116327-7	2021	Enzymatic assays revealed that the selected derivatives were superior to the reference MMP-9 and MAO-A inhibitors (quercetin and clorgyline, respectively).	Quercetin	115-124	monoamine oxidase A	Homo sapiens	97-102
34681913-7	2021	Low-dose quercetin reduced HSP72 expression, increased HDAC activity, and enhanced vorinostat-induced suppression of Hut78 cell proliferation.	Quercetin	9-18	heat shock protein family A (Hsp70) member 1A	Homo sapiens	27-32
34681913-9	2021	Quercetin also significantly enhanced vorinostat-induced apoptosis, caspase-3, caspase-8, and caspase-9 activity, and the loss of mitochondrial membrane potential.	Quercetin	0-9	caspase 3	Homo sapiens	68-77
34681913-9	2021	Quercetin also significantly enhanced vorinostat-induced apoptosis, caspase-3, caspase-8, and caspase-9 activity, and the loss of mitochondrial membrane potential.	Quercetin	0-9	caspase 8	Homo sapiens	79-88
34681913-9	2021	Quercetin also significantly enhanced vorinostat-induced apoptosis, caspase-3, caspase-8, and caspase-9 activity, and the loss of mitochondrial membrane potential.	Quercetin	0-9	caspase 9	Homo sapiens	94-103
34681913-10	2021	HSP72 knockdown enhanced vorinostat-induced apoptosis in an HSP72-overexpressing CTCL cell line, and thus, quercetin may be a suitable candidate for combination therapy with vorinostat in clinical settings.	Quercetin	107-116	heat shock protein family A (Hsp70) member 1A	Homo sapiens	0-5
34469746-8	2021	This method was successfully applied to quantify the uptake of GLUT1-mediated 2-NBDG, and the results clearly indicated inhibition of GLUT1 by WZB117 and quercetin (two potent glucose transporter inhibitors) in the GLUT1-HEK293T cell model.	Quercetin	154-163	solute carrier family 2 member 1	Homo sapiens	134-139
34469746-8	2021	This method was successfully applied to quantify the uptake of GLUT1-mediated 2-NBDG, and the results clearly indicated inhibition of GLUT1 by WZB117 and quercetin (two potent glucose transporter inhibitors) in the GLUT1-HEK293T cell model.	Quercetin	154-163	solute carrier family 2 member 1	Homo sapiens	215-220
34671661-10	2021	Taken together, our study showed that the traditional Chinese medicine QJC, quercetin, luteolin, kaempferol, scutellarein, and stigmasterol alleviated the pathological condition of small intestine tissue and relieved stress-induced diarrhea by increasing the expression levels of PI3K and Akt and inhibiting the expression levels of PTEN.	Quercetin	76-85	thymoma viral proto-oncogene 1	Mus musculus	289-292
34636440-0	2022	Thymoquinone and quercetin induce enhanced apoptosis in non-small cell lung cancer in combination through the Bax/Bcl2 cascade.	Quercetin	17-26	BCL2 associated X, apoptosis regulator	Homo sapiens	110-113
34636440-0	2022	Thymoquinone and quercetin induce enhanced apoptosis in non-small cell lung cancer in combination through the Bax/Bcl2 cascade.	Quercetin	17-26	BCL2 apoptosis regulator	Homo sapiens	114-118
34636440-4	2022	Molecular docking followed by molecular dynamics (MD) simulation of thymoquinone (Tq) and quercetin (Qu) with Bax and Bcl2 were carried out to explore their interactions and stability under explicit solvent conditions.	Quercetin	90-99	BCL2 associated X, apoptosis regulator	Homo sapiens	110-113
34636440-4	2022	Molecular docking followed by molecular dynamics (MD) simulation of thymoquinone (Tq) and quercetin (Qu) with Bax and Bcl2 were carried out to explore their interactions and stability under explicit solvent conditions.	Quercetin	90-99	BCL2 apoptosis regulator	Homo sapiens	118-122
34684707-7	2021	Results show that rats pretreated with quercetin before ischemia significantly increased Mg, Zn, Se, SOD, and CAT levels, while the malondialdehyde, Fe, Cu, and the Cu/Zn ratio clearly decreased as compared to the untreated ligation subject.	Quercetin	39-48	catalase	Rattus norvegicus	110-113
34660782-11	2021	This study revealed that SZRD has the characteristics and advantages of "multicomponent, multitarget, and multipathway" in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms.	Quercetin	208-217	AKT serine/threonine kinase 1	Homo sapiens	257-261
34660782-11	2021	This study revealed that SZRD has the characteristics and advantages of "multicomponent, multitarget, and multipathway" in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms.	Quercetin	208-217	interleukin 6	Homo sapiens	263-266
34660782-11	2021	This study revealed that SZRD has the characteristics and advantages of "multicomponent, multitarget, and multipathway" in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms.	Quercetin	208-217	mitogen-activated protein kinase 1	Homo sapiens	268-273
34660782-11	2021	This study revealed that SZRD has the characteristics and advantages of "multicomponent, multitarget, and multipathway" in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms.	Quercetin	208-217	tumor protein p53	Homo sapiens	275-279
34660782-11	2021	This study revealed that SZRD has the characteristics and advantages of "multicomponent, multitarget, and multipathway" in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms.	Quercetin	208-217	vascular endothelial growth factor A	Homo sapiens	285-290
34646329-12	2021	Molecular docking revealed a good binding affinity of active components (quercetin, bisdemethoxycurcumin, and kaempferol) with the corresponding targets (CYP3A4, CYP1A1, HMOX1, DRD2, DPP4, ADRA2A, ADRA2C, NR1I2, and LGALS4).	Quercetin	73-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	154-160
34646329-12	2021	Molecular docking revealed a good binding affinity of active components (quercetin, bisdemethoxycurcumin, and kaempferol) with the corresponding targets (CYP3A4, CYP1A1, HMOX1, DRD2, DPP4, ADRA2A, ADRA2C, NR1I2, and LGALS4).	Quercetin	73-82	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	162-168
34646329-12	2021	Molecular docking revealed a good binding affinity of active components (quercetin, bisdemethoxycurcumin, and kaempferol) with the corresponding targets (CYP3A4, CYP1A1, HMOX1, DRD2, DPP4, ADRA2A, ADRA2C, NR1I2, and LGALS4).	Quercetin	73-82	heme oxygenase 1	Homo sapiens	170-175
34646329-12	2021	Molecular docking revealed a good binding affinity of active components (quercetin, bisdemethoxycurcumin, and kaempferol) with the corresponding targets (CYP3A4, CYP1A1, HMOX1, DRD2, DPP4, ADRA2A, ADRA2C, NR1I2, and LGALS4).	Quercetin	73-82	dopamine receptor D2	Homo sapiens	177-181
34646329-12	2021	Molecular docking revealed a good binding affinity of active components (quercetin, bisdemethoxycurcumin, and kaempferol) with the corresponding targets (CYP3A4, CYP1A1, HMOX1, DRD2, DPP4, ADRA2A, ADRA2C, NR1I2, and LGALS4).	Quercetin	73-82	dipeptidyl peptidase 4	Homo sapiens	183-187
34646329-12	2021	Molecular docking revealed a good binding affinity of active components (quercetin, bisdemethoxycurcumin, and kaempferol) with the corresponding targets (CYP3A4, CYP1A1, HMOX1, DRD2, DPP4, ADRA2A, ADRA2C, NR1I2, and LGALS4).	Quercetin	73-82	adrenoceptor alpha 2A	Homo sapiens	189-195
34646329-12	2021	Molecular docking revealed a good binding affinity of active components (quercetin, bisdemethoxycurcumin, and kaempferol) with the corresponding targets (CYP3A4, CYP1A1, HMOX1, DRD2, DPP4, ADRA2A, ADRA2C, NR1I2, and LGALS4).	Quercetin	73-82	adrenoceptor alpha 2C	Homo sapiens	197-203
34646329-12	2021	Molecular docking revealed a good binding affinity of active components (quercetin, bisdemethoxycurcumin, and kaempferol) with the corresponding targets (CYP3A4, CYP1A1, HMOX1, DRD2, DPP4, ADRA2A, ADRA2C, NR1I2, and LGALS4).	Quercetin	73-82	nuclear receptor subfamily 1 group I member 2	Homo sapiens	205-210
34646329-12	2021	Molecular docking revealed a good binding affinity of active components (quercetin, bisdemethoxycurcumin, and kaempferol) with the corresponding targets (CYP3A4, CYP1A1, HMOX1, DRD2, DPP4, ADRA2A, ADRA2C, NR1I2, and LGALS4).	Quercetin	73-82	galectin 4	Homo sapiens	216-222
34671661-10	2021	Taken together, our study showed that the traditional Chinese medicine QJC, quercetin, luteolin, kaempferol, scutellarein, and stigmasterol alleviated the pathological condition of small intestine tissue and relieved stress-induced diarrhea by increasing the expression levels of PI3K and Akt and inhibiting the expression levels of PTEN.	Quercetin	76-85	phosphatase and tensin homolog	Mus musculus	333-337
34185887-9	2021	Molecular docking results revealed that quercetin and kaempferol bind to AKT1 and formononetin binds to RELA, all of which were found to be stable bounds.	Quercetin	40-49	AKT serine/threonine kinase 1	Homo sapiens	73-77
34641548-5	2021	In addition, both NEA3 and NEA1 showed efficient BACE1 inhibitions with IC50 values of 8.02 +- 0.13 and 8.21 +- 0.03 microM better than the standard quercetin value (13.40 +- 0.04 microM).	Quercetin	149-158	beta-secretase 1	Homo sapiens	49-54
34388484-0	2021	Essential moieties of myricetins, quercetins and catechins for binding and inhibitory activity against alpha-Glucosidase.	Quercetin	34-44	sucrase-isomaltase	Homo sapiens	103-120
34392086-7	2021	Moreover, quercetin at a concentration of 10 microM protected cells by reducing damage from treatment factors (tumor necrosis factor alpha and cycloheximide) by 40%, enhancing cellular migration and depolarizing the mitochondrial membrane.	Quercetin	10-19	tumor necrosis factor	Homo sapiens	111-138
34388484-1	2021	alpha-Glucosidase inhibition of 11 flavonoids, including myricetins, quercetins and catechins were studied through initial reaction velocity, IC50 value, inhibition kinetics, fluorescence quenching and molecular docking.	Quercetin	69-79	sucrase-isomaltase	Homo sapiens	0-17
34227734-7	2021	Quercetin reduced the expression of p53 protein in zebrafish larvae injured by TAA, resulting in decreased levels of Bax and increased levels of Bcl-2.	Quercetin	0-9	tumor protein p53	Danio rerio	36-39
34227734-7	2021	Quercetin reduced the expression of p53 protein in zebrafish larvae injured by TAA, resulting in decreased levels of Bax and increased levels of Bcl-2.	Quercetin	0-9	BCL2 associated X, apoptosis regulator a	Danio rerio	117-120
34227734-7	2021	Quercetin reduced the expression of p53 protein in zebrafish larvae injured by TAA, resulting in decreased levels of Bax and increased levels of Bcl-2.	Quercetin	0-9	BCL2 apoptosis regulator a	Danio rerio	145-150
34227734-9	2021	Quercetin reduced the expression of DKK1 and DKK2 genes related to the Wnt signaling pathway in zebrafish larvae damaged by TAA and increased the expression of Lef1 and wnt2bb.	Quercetin	0-9	dickkopf WNT signaling pathway inhibitor 1b	Danio rerio	36-40
34661255-1	2021	OBJECTIVE: To explore the therapeutic effects of quercetin on rats with encephalitis, especially on cell apoptosis, and the levels of HMGB-1 and TLR-4.	Quercetin	49-58	high mobility group box 1	Rattus norvegicus	134-140
34227734-9	2021	Quercetin reduced the expression of DKK1 and DKK2 genes related to the Wnt signaling pathway in zebrafish larvae damaged by TAA and increased the expression of Lef1 and wnt2bb.	Quercetin	0-9	dickkopf WNT signaling pathway inhibitor 2	Danio rerio	45-49
34661255-1	2021	OBJECTIVE: To explore the therapeutic effects of quercetin on rats with encephalitis, especially on cell apoptosis, and the levels of HMGB-1 and TLR-4.	Quercetin	49-58	toll-like receptor 4	Rattus norvegicus	145-150
34661255-7	2021	CONCLUSIONS: Quercetin is effective in treating encephalitis rats possibly through inhibition of neuronal cell apoptosis and level of HMGB-1 and TLR-4.	Quercetin	13-22	high mobility group box 1	Rattus norvegicus	134-140
34661255-7	2021	CONCLUSIONS: Quercetin is effective in treating encephalitis rats possibly through inhibition of neuronal cell apoptosis and level of HMGB-1 and TLR-4.	Quercetin	13-22	toll-like receptor 4	Rattus norvegicus	145-150
34227734-9	2021	Quercetin reduced the expression of DKK1 and DKK2 genes related to the Wnt signaling pathway in zebrafish larvae damaged by TAA and increased the expression of Lef1 and wnt2bb.	Quercetin	0-9	lymphoid enhancer-binding factor 1	Danio rerio	160-164
34227734-9	2021	Quercetin reduced the expression of DKK1 and DKK2 genes related to the Wnt signaling pathway in zebrafish larvae damaged by TAA and increased the expression of Lef1 and wnt2bb.	Quercetin	0-9	wingless-type MMTV integration site family, member 2Bb	Danio rerio	169-175
34350508-5	2021	Docking results showed that rutin, puerarin, baicalin, luteolin and quercetin are the most potent TXNIP inhibitors, and among them, rutin as the most effective flavonoid.	Quercetin	68-77	thioredoxin interacting protein	Homo sapiens	98-103
34380011-6	2021	Pre-treatment with QUE also prevented STE-induced nuclear translocation of NF-kappaB, as measured by immunofluorescence.	Quercetin	19-22	nuclear factor kappa B subunit 1	Homo sapiens	75-84
34380011-9	2021	In QUE pre-treated samples, TNF-alpha and IL-6 were significantly further reduced, indicating the anti-inflammatory role of QUE.	Quercetin	3-6	tumor necrosis factor	Homo sapiens	28-37
34380011-9	2021	In QUE pre-treated samples, TNF-alpha and IL-6 were significantly further reduced, indicating the anti-inflammatory role of QUE.	Quercetin	3-6	interleukin 6	Homo sapiens	42-46
34380011-9	2021	In QUE pre-treated samples, TNF-alpha and IL-6 were significantly further reduced, indicating the anti-inflammatory role of QUE.	Quercetin	124-127	tumor necrosis factor	Homo sapiens	28-37
34380011-9	2021	In QUE pre-treated samples, TNF-alpha and IL-6 were significantly further reduced, indicating the anti-inflammatory role of QUE.	Quercetin	124-127	interleukin 6	Homo sapiens	42-46
34278923-8	2021	Effects of quercetin on repair and regenerations of diabetic wounds in terms of wound closure, inflammation, angiogenesis, fibroblast proliferation, collagen synthesis, epithelialization, axonal regeneration etc was studied.Results: Quercetin accelerated the wound closure and increased the expressions of IL-10, VEGF and TGF-beta1 in granulation/healing tissue of diabetic wound.	Quercetin	11-20	interleukin 10	Rattus norvegicus	306-311
34278923-8	2021	Effects of quercetin on repair and regenerations of diabetic wounds in terms of wound closure, inflammation, angiogenesis, fibroblast proliferation, collagen synthesis, epithelialization, axonal regeneration etc was studied.Results: Quercetin accelerated the wound closure and increased the expressions of IL-10, VEGF and TGF-beta1 in granulation/healing tissue of diabetic wound.	Quercetin	11-20	vascular endothelial growth factor A	Rattus norvegicus	313-317
34308732-0	2021	Quercetin protects oral mucosal keratinocytes against lipopolysaccharide-induced inflammatory toxicity by suppressing the AKT/AMPK/mTOR pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	122-125
34278923-8	2021	Effects of quercetin on repair and regenerations of diabetic wounds in terms of wound closure, inflammation, angiogenesis, fibroblast proliferation, collagen synthesis, epithelialization, axonal regeneration etc was studied.Results: Quercetin accelerated the wound closure and increased the expressions of IL-10, VEGF and TGF-beta1 in granulation/healing tissue of diabetic wound.	Quercetin	11-20	transforming growth factor, beta 1	Rattus norvegicus	322-331
34278923-8	2021	Effects of quercetin on repair and regenerations of diabetic wounds in terms of wound closure, inflammation, angiogenesis, fibroblast proliferation, collagen synthesis, epithelialization, axonal regeneration etc was studied.Results: Quercetin accelerated the wound closure and increased the expressions of IL-10, VEGF and TGF-beta1 in granulation/healing tissue of diabetic wound.	Quercetin	233-242	interleukin 10	Rattus norvegicus	306-311
34278923-8	2021	Effects of quercetin on repair and regenerations of diabetic wounds in terms of wound closure, inflammation, angiogenesis, fibroblast proliferation, collagen synthesis, epithelialization, axonal regeneration etc was studied.Results: Quercetin accelerated the wound closure and increased the expressions of IL-10, VEGF and TGF-beta1 in granulation/healing tissue of diabetic wound.	Quercetin	233-242	vascular endothelial growth factor A	Rattus norvegicus	313-317
34278923-8	2021	Effects of quercetin on repair and regenerations of diabetic wounds in terms of wound closure, inflammation, angiogenesis, fibroblast proliferation, collagen synthesis, epithelialization, axonal regeneration etc was studied.Results: Quercetin accelerated the wound closure and increased the expressions of IL-10, VEGF and TGF-beta1 in granulation/healing tissue of diabetic wound.	Quercetin	233-242	transforming growth factor, beta 1	Rattus norvegicus	322-331
34278923-9	2021	However, quercetin decreased the expression of TNF-alpha, IL-1beta, and MMP-9.	Quercetin	9-18	tumor necrosis factor	Rattus norvegicus	47-56
34278923-9	2021	However, quercetin decreased the expression of TNF-alpha, IL-1beta, and MMP-9.	Quercetin	9-18	interleukin 1 alpha	Rattus norvegicus	58-66
34308732-0	2021	Quercetin protects oral mucosal keratinocytes against lipopolysaccharide-induced inflammatory toxicity by suppressing the AKT/AMPK/mTOR pathway.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	126-130
34308732-0	2021	Quercetin protects oral mucosal keratinocytes against lipopolysaccharide-induced inflammatory toxicity by suppressing the AKT/AMPK/mTOR pathway.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	131-135
34308732-6	2021	RESULTS: Quercetin significantly improved cell viability and apoptosis by reversing LPS-induced upregulation of Bax and downregulation of Bcl-2 in hOMK107 cells.	Quercetin	9-18	BCL2 associated X, apoptosis regulator	Homo sapiens	112-115
34308732-6	2021	RESULTS: Quercetin significantly improved cell viability and apoptosis by reversing LPS-induced upregulation of Bax and downregulation of Bcl-2 in hOMK107 cells.	Quercetin	9-18	BCL2 apoptosis regulator	Homo sapiens	138-143
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	interleukin 1 alpha	Homo sapiens	38-46
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	interleukin 6	Homo sapiens	48-52
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
34278923-9	2021	However, quercetin decreased the expression of TNF-alpha, IL-1beta, and MMP-9.	Quercetin	9-18	matrix metallopeptidase 9	Rattus norvegicus	72-77
34278923-13	2021	Results of immunohistochemistry showed more angiogenesis, faster phenotypic switching of fibroblast to myofibroblasts and increased GAP-43 positive nerve fibers in quercetin-treated diabetic wounds.Conclusion: Quercetin ointment at 0.3% w/w concentration modulates cytokines, growth factors and protease, thereby improved repair and regenerations of cutaneous diabetic wounds in rats.	Quercetin	164-173	growth associated protein 43	Rattus norvegicus	132-138
34278923-13	2021	Results of immunohistochemistry showed more angiogenesis, faster phenotypic switching of fibroblast to myofibroblasts and increased GAP-43 positive nerve fibers in quercetin-treated diabetic wounds.Conclusion: Quercetin ointment at 0.3% w/w concentration modulates cytokines, growth factors and protease, thereby improved repair and regenerations of cutaneous diabetic wounds in rats.	Quercetin	210-219	growth associated protein 43	Rattus norvegicus	132-138
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	60-69
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	inositol-3-phosphate synthase 1	Homo sapiens	71-75
34426107-0	2021	Micro RNAs 26b, 20a inversely correlate with GSK-3 beta/NF-kappaB/NLRP-3 pathway to highlight the additive promising effects of atorvastatin and quercetin in experimental induced arthritis.	Quercetin	145-154	glycogen synthase kinase 3 alpha	Rattus norvegicus	45-55
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	127-130
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	131-135
34308732-7	2021	Quercetin decreased the production of IL-1beta, IL-6, IL-8, TNF-alpha, iNOS, and COX-2, as well as signal transduction via the Akt/AMPK/mTOR pathway.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	136-140
34308732-8	2021	Inhibitors of Akt, AMPK, and mTOR strengthened the anti-apoptotic effects of quercetin, while agonists of Akt, AMPK, or mTOR or Akt overexpression weakened the anti-apoptotic effects.	Quercetin	77-86	AKT serine/threonine kinase 1	Homo sapiens	14-17
34308732-8	2021	Inhibitors of Akt, AMPK, and mTOR strengthened the anti-apoptotic effects of quercetin, while agonists of Akt, AMPK, or mTOR or Akt overexpression weakened the anti-apoptotic effects.	Quercetin	77-86	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	19-23
34308732-8	2021	Inhibitors of Akt, AMPK, and mTOR strengthened the anti-apoptotic effects of quercetin, while agonists of Akt, AMPK, or mTOR or Akt overexpression weakened the anti-apoptotic effects.	Quercetin	77-86	mechanistic target of rapamycin kinase	Homo sapiens	29-33
34308732-9	2021	CONCLUSION: These results indicate that quercetin may have a potential protective effect against the chronic inflammation-related periodontitis via suppressing Akt/AMPK/mTOR pathway.	Quercetin	40-49	AKT serine/threonine kinase 1	Homo sapiens	160-163
34308732-9	2021	CONCLUSION: These results indicate that quercetin may have a potential protective effect against the chronic inflammation-related periodontitis via suppressing Akt/AMPK/mTOR pathway.	Quercetin	40-49	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	164-168
34308732-9	2021	CONCLUSION: These results indicate that quercetin may have a potential protective effect against the chronic inflammation-related periodontitis via suppressing Akt/AMPK/mTOR pathway.	Quercetin	40-49	mechanistic target of rapamycin kinase	Homo sapiens	169-173
34426107-0	2021	Micro RNAs 26b, 20a inversely correlate with GSK-3 beta/NF-kappaB/NLRP-3 pathway to highlight the additive promising effects of atorvastatin and quercetin in experimental induced arthritis.	Quercetin	145-154	NLR family, pyrin domain containing 3	Rattus norvegicus	66-72
34820315-8	2021	By in silico study presented that ursolic acid inhibited SOD enzyme with a binding affinity of - 5.4 kcal/mol those higher than a quercetin as a positive control.	Quercetin	130-139	superoxide dismutase 1	Homo sapiens	57-60
34641514-3	2021	The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,2",4"-trihydroxy-4-methoxychalcone, stigmasterol and beta-sitosterol.	Quercetin	103-112	sucrase-isomaltase	Homo sapiens	4-21
34535900-4	2021	Compared with positive controls, acarbose and miglito, most polyphenols, especially the four aglycones (cyanidin, quercetin, phloretin, and 3-hydroxyphloretin) showed higher inhibition rates on alpha-glucosidase.	Quercetin	114-123	sucrase-isomaltase	Homo sapiens	194-211
34708631-6	2021	CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway.	Quercetin	53-62	mitogen activated protein kinase 14	Rattus norvegicus	173-176
34708631-6	2021	CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway.	Quercetin	53-62	mitogen-activated protein kinase 8	Rattus norvegicus	181-184
34708631-6	2021	CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway.	Quercetin	53-62	mitogen activated protein kinase 14	Rattus norvegicus	188-191
34708631-6	2021	CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway.	Quercetin	53-62	mitogen-activated protein kinase 8	Rattus norvegicus	230-233
34390063-5	2021	Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1beta suppression.	Quercetin	112-121	interleukin 1 alpha	Homo sapiens	148-156
34101925-4	2021	According to these data, quercetin may also have a role in the management of metabolic disorders via different mechanisms such as increasing adiponectin, decreasing leptin, anti-oxidant activity, reduction of insulin resistance, the elevation of insulin level, and blocking of calcium channel.	Quercetin	25-34	adiponectin, C1Q and collagen domain containing	Homo sapiens	141-152
34101925-4	2021	According to these data, quercetin may also have a role in the management of metabolic disorders via different mechanisms such as increasing adiponectin, decreasing leptin, anti-oxidant activity, reduction of insulin resistance, the elevation of insulin level, and blocking of calcium channel.	Quercetin	25-34	leptin	Homo sapiens	165-171
34101925-4	2021	According to these data, quercetin may also have a role in the management of metabolic disorders via different mechanisms such as increasing adiponectin, decreasing leptin, anti-oxidant activity, reduction of insulin resistance, the elevation of insulin level, and blocking of calcium channel.	Quercetin	25-34	insulin	Homo sapiens	209-216
34101925-4	2021	According to these data, quercetin may also have a role in the management of metabolic disorders via different mechanisms such as increasing adiponectin, decreasing leptin, anti-oxidant activity, reduction of insulin resistance, the elevation of insulin level, and blocking of calcium channel.	Quercetin	25-34	insulin	Homo sapiens	246-253
34592982-0	2021	Quercetin promotes bone marrow mesenchymal stem cell proliferation and osteogenic differentiation through the H19/miR-625-5p axis to activate the Wnt/beta-catenin pathway.	Quercetin	0-9	H19 imprinted maternally expressed transcript	Homo sapiens	110-113
34592982-0	2021	Quercetin promotes bone marrow mesenchymal stem cell proliferation and osteogenic differentiation through the H19/miR-625-5p axis to activate the Wnt/beta-catenin pathway.	Quercetin	0-9	microRNA 625	Homo sapiens	114-121
34592982-0	2021	Quercetin promotes bone marrow mesenchymal stem cell proliferation and osteogenic differentiation through the H19/miR-625-5p axis to activate the Wnt/beta-catenin pathway.	Quercetin	0-9	catenin beta 1	Homo sapiens	150-162
34592982-5	2021	RESULTS: Quercetin promoted BMSC proliferation, enhanced ALP activity, and upregulated the expression of BMP-2, osteocalcin, and RUNX2 mRNAs, suggesting that it promoted osteogenic differentiation of BMSCs.	Quercetin	9-18	alkaline phosphatase, placental	Homo sapiens	57-60
34592982-5	2021	RESULTS: Quercetin promoted BMSC proliferation, enhanced ALP activity, and upregulated the expression of BMP-2, osteocalcin, and RUNX2 mRNAs, suggesting that it promoted osteogenic differentiation of BMSCs.	Quercetin	9-18	bone morphogenetic protein 2	Homo sapiens	105-110
34592982-5	2021	RESULTS: Quercetin promoted BMSC proliferation, enhanced ALP activity, and upregulated the expression of BMP-2, osteocalcin, and RUNX2 mRNAs, suggesting that it promoted osteogenic differentiation of BMSCs.	Quercetin	9-18	bone gamma-carboxyglutamate protein	Homo sapiens	112-123
34592982-5	2021	RESULTS: Quercetin promoted BMSC proliferation, enhanced ALP activity, and upregulated the expression of BMP-2, osteocalcin, and RUNX2 mRNAs, suggesting that it promoted osteogenic differentiation of BMSCs.	Quercetin	9-18	RUNX family transcription factor 2	Homo sapiens	129-134
34592982-6	2021	Moreover, quercetin increased H19 expression, while the effect of quercetin on BMSCs was reversed by silencing H19 expression.	Quercetin	10-19	H19 imprinted maternally expressed transcript	Homo sapiens	30-33
34592982-6	2021	Moreover, quercetin increased H19 expression, while the effect of quercetin on BMSCs was reversed by silencing H19 expression.	Quercetin	10-19	H19 imprinted maternally expressed transcript	Homo sapiens	111-114
34592982-6	2021	Moreover, quercetin increased H19 expression, while the effect of quercetin on BMSCs was reversed by silencing H19 expression.	Quercetin	66-75	H19 imprinted maternally expressed transcript	Homo sapiens	111-114
34592982-7	2021	Additionally, miR-625-5p, interacted with H19, was downregulated during quercetin-induced BMSC osteogenic differentiation, which negatively correlated with H19 expression.	Quercetin	72-81	microRNA 625	Homo sapiens	14-21
34592982-7	2021	Additionally, miR-625-5p, interacted with H19, was downregulated during quercetin-induced BMSC osteogenic differentiation, which negatively correlated with H19 expression.	Quercetin	72-81	H19 imprinted maternally expressed transcript	Homo sapiens	42-45
34592982-7	2021	Additionally, miR-625-5p, interacted with H19, was downregulated during quercetin-induced BMSC osteogenic differentiation, which negatively correlated with H19 expression.	Quercetin	72-81	H19 imprinted maternally expressed transcript	Homo sapiens	156-159
34592982-9	2021	Finally, quercetin treatment or downregulation of miR-625-5p expression increased beta-catenin protein level in BMSCs.	Quercetin	9-18	catenin beta 1	Homo sapiens	82-94
34592918-6	2021	Recently, quercetin-like flavonoid compounds with OH groups in their B-rings have been found to serve as activators of COX-2 by binding the POX site.	Quercetin	10-19	prostaglandin-endoperoxide synthase 2	Homo sapiens	119-124
34592918-10	2021	This review focuses on the most compelling evidence regarding the role and mechanism of COX-2 in cardiovascular diseases and demonstrates that quercetin-like compounds exert potential cardioprotective effects by serving as cofactors of COX-2.	Quercetin	143-152	prostaglandin-endoperoxide synthase 2	Homo sapiens	88-93
34592918-10	2021	This review focuses on the most compelling evidence regarding the role and mechanism of COX-2 in cardiovascular diseases and demonstrates that quercetin-like compounds exert potential cardioprotective effects by serving as cofactors of COX-2.	Quercetin	143-152	prostaglandin-endoperoxide synthase 2	Homo sapiens	236-241
34592982-10	2021	Upregulation or downregulation of miR-625-5p or H19 expression, respectively, inhibited beta-catenin protein level in quercetin treated-BMSCs.	Quercetin	118-127	microRNA 625	Homo sapiens	34-41
34592982-10	2021	Upregulation or downregulation of miR-625-5p or H19 expression, respectively, inhibited beta-catenin protein level in quercetin treated-BMSCs.	Quercetin	118-127	H19 imprinted maternally expressed transcript	Homo sapiens	48-51
34592982-10	2021	Upregulation or downregulation of miR-625-5p or H19 expression, respectively, inhibited beta-catenin protein level in quercetin treated-BMSCs.	Quercetin	118-127	catenin beta 1	Homo sapiens	88-100
34592982-12	2021	Quercetin activates the Wnt/beta-catenin pathway and promotes BMSC osteogenic differentiation via the H19/miR-625-5p axis.	Quercetin	0-9	catenin beta 1	Homo sapiens	28-40
34592982-12	2021	Quercetin activates the Wnt/beta-catenin pathway and promotes BMSC osteogenic differentiation via the H19/miR-625-5p axis.	Quercetin	0-9	H19 imprinted maternally expressed transcript	Homo sapiens	102-105
34592982-12	2021	Quercetin activates the Wnt/beta-catenin pathway and promotes BMSC osteogenic differentiation via the H19/miR-625-5p axis.	Quercetin	0-9	microRNA 625	Homo sapiens	106-113
34603599-0	2021	SIRT5-Related Desuccinylation Modification Contributes to Quercetin-Induced Protection against Heart Failure and High-Glucose-Prompted Cardiomyocytes Injured through Regulation of Mitochondrial Quality Surveillance.	Quercetin	58-67	sirtuin 5	Mus musculus	0-5
34641354-0	2021	STL1, a New AKT Inhibitor, Synergizes with Flavonoid Quercetin in Enhancing Cell Death in A Chronic Lymphocytic Leukemia Cell Line.	Quercetin	53-62	collagen type II alpha 1 chain	Homo sapiens	0-4
34641354-0	2021	STL1, a New AKT Inhibitor, Synergizes with Flavonoid Quercetin in Enhancing Cell Death in A Chronic Lymphocytic Leukemia Cell Line.	Quercetin	53-62	AKT serine/threonine kinase 1	Homo sapiens	12-15
34641354-3	2021	Moreover, we demonstrated that the flavonoid quercetin downregulated the phosphorylated and active form of AKT.	Quercetin	45-54	AKT serine/threonine kinase 1	Homo sapiens	107-110
34641354-4	2021	However, in this case, quercetin inhibited the PI3K/AKT pathway by directly binding the kinases CK2 and PI3K.	Quercetin	23-32	AKT serine/threonine kinase 1	Homo sapiens	52-55
34641354-6	2021	Quercetin and STL1 in the mono-treatment maintained the capacity to inhibit AKT phosphorylation on Ser473, but did not significantly reduce cell viability.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	76-79
34582743-0	2022	Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats.	Quercetin	0-9	microRNA 1306	Rattus norvegicus	109-117
34582743-0	2022	Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats.	Quercetin	0-9	hydroxysteroid (17-beta) dehydrogenase 7	Rattus norvegicus	121-128
34582743-14	2022	In conclusion, quercetin inhibits ER stress and improves testosterone secretion disorder through the miR-1306-5p/HSD17B7 axis in diabetic rats.	Quercetin	15-24	microRNA 1306	Rattus norvegicus	101-109
34582743-14	2022	In conclusion, quercetin inhibits ER stress and improves testosterone secretion disorder through the miR-1306-5p/HSD17B7 axis in diabetic rats.	Quercetin	15-24	hydroxysteroid (17-beta) dehydrogenase 7	Rattus norvegicus	113-120
34603599-11	2021	However, quercetin promoted the desuccinylation of IDH2 by increasing SIRT5 expression.	Quercetin	9-18	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	51-55
34603599-11	2021	However, quercetin promoted the desuccinylation of IDH2 by increasing SIRT5 expression.	Quercetin	9-18	sirtuin 5	Mus musculus	70-75
34603599-12	2021	Moreover, treatment with si-SIRT5 abolished the protective effect of quercetin on cell viability.	Quercetin	69-78	sirtuin 5	Mus musculus	28-33
34603599-13	2021	Hence, quercetin may promote the desuccinylation of IDH2 through SIRT5, maintain mitochondrial homeostasis, protect mouse cardiomyocytes under inflammatory conditions, and improve myocardial fibrosis, thereby reducing the incidence of heart failure.	Quercetin	7-16	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	52-56
34603599-13	2021	Hence, quercetin may promote the desuccinylation of IDH2 through SIRT5, maintain mitochondrial homeostasis, protect mouse cardiomyocytes under inflammatory conditions, and improve myocardial fibrosis, thereby reducing the incidence of heart failure.	Quercetin	7-16	sirtuin 5	Mus musculus	65-70
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	tumor necrosis factor	Rattus norvegicus	152-161
34595237-7	2021	The results of molecular docking showed that AKT has the most binding activity, exhibiting certain binding activity with 10 compounds, including vanillic acid, protocatechuic acid, secologanic acid, quercetin, and luteolin; the results of qRT-PCR and WB confirmed that two key compounds, secologanic acid and luteolin, could significantly decrease the secretion of TNF-alpha and the AKT expression of RAW264.7 murine macrophages stimulated by LPS (lipopolysaccharide).	Quercetin	199-208	thymoma viral proto-oncogene 1	Mus musculus	45-48
34595237-7	2021	The results of molecular docking showed that AKT has the most binding activity, exhibiting certain binding activity with 10 compounds, including vanillic acid, protocatechuic acid, secologanic acid, quercetin, and luteolin; the results of qRT-PCR and WB confirmed that two key compounds, secologanic acid and luteolin, could significantly decrease the secretion of TNF-alpha and the AKT expression of RAW264.7 murine macrophages stimulated by LPS (lipopolysaccharide).	Quercetin	199-208	tumor necrosis factor	Mus musculus	365-374
34595237-7	2021	The results of molecular docking showed that AKT has the most binding activity, exhibiting certain binding activity with 10 compounds, including vanillic acid, protocatechuic acid, secologanic acid, quercetin, and luteolin; the results of qRT-PCR and WB confirmed that two key compounds, secologanic acid and luteolin, could significantly decrease the secretion of TNF-alpha and the AKT expression of RAW264.7 murine macrophages stimulated by LPS (lipopolysaccharide).	Quercetin	199-208	thymoma viral proto-oncogene 1	Mus musculus	383-386
34523301-11	2021	The Q also decreased free radical oxidation in the heart mitochondria of diabetic animals, thus limiting the formation of advanced oxidation protein products in a dose-dependent manner and normalized the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, glutathione reductase) in cardiac mitochondria independently of the dose used.	Quercetin	4-5	glutathione-disulfide reductase	Rattus norvegicus	283-304
34538551-0	2022	Mechanism of quercetin on the improvement of ovulation disorder and regulation of ovarian CNP/NPR2 in PCOS model rats.	Quercetin	13-22	natriuretic peptide receptor 2	Rattus norvegicus	94-98
34538551-1	2022	PURPOSE: To investigate the effects of quercetin on ovulation disorder and expression of androgen receptor (AR) and C-type natriuretic peptide (CNP) / Natriuretic Peptide Receptor 2 (NPR2) in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat model.	Quercetin	39-48	androgen receptor	Rattus norvegicus	89-106
34538551-1	2022	PURPOSE: To investigate the effects of quercetin on ovulation disorder and expression of androgen receptor (AR) and C-type natriuretic peptide (CNP) / Natriuretic Peptide Receptor 2 (NPR2) in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat model.	Quercetin	39-48	androgen receptor	Rattus norvegicus	108-110
34538551-1	2022	PURPOSE: To investigate the effects of quercetin on ovulation disorder and expression of androgen receptor (AR) and C-type natriuretic peptide (CNP) / Natriuretic Peptide Receptor 2 (NPR2) in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat model.	Quercetin	39-48	natriuretic peptide C	Rattus norvegicus	116-142
34538551-1	2022	PURPOSE: To investigate the effects of quercetin on ovulation disorder and expression of androgen receptor (AR) and C-type natriuretic peptide (CNP) / Natriuretic Peptide Receptor 2 (NPR2) in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat model.	Quercetin	39-48	natriuretic peptide C	Rattus norvegicus	144-147
34538551-1	2022	PURPOSE: To investigate the effects of quercetin on ovulation disorder and expression of androgen receptor (AR) and C-type natriuretic peptide (CNP) / Natriuretic Peptide Receptor 2 (NPR2) in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat model.	Quercetin	39-48	natriuretic peptide receptor 2	Rattus norvegicus	151-181
34538551-1	2022	PURPOSE: To investigate the effects of quercetin on ovulation disorder and expression of androgen receptor (AR) and C-type natriuretic peptide (CNP) / Natriuretic Peptide Receptor 2 (NPR2) in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat model.	Quercetin	39-48	natriuretic peptide receptor 2	Rattus norvegicus	183-187
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	BCL2 associated X, apoptosis regulator	Rattus norvegicus	128-131
34566654-3	2021	Significant reductions in transepithelial electrical resistance, occludin, and zonula occludens-1(ZO-1) levels were detected in the MC-LR-treated TM4 cells, and quercetin attenuated these effects.	Quercetin	161-170	occludin	Mus musculus	65-73
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	interleukin 1 alpha	Rattus norvegicus	133-141
34566654-3	2021	Significant reductions in transepithelial electrical resistance, occludin, and zonula occludens-1(ZO-1) levels were detected in the MC-LR-treated TM4 cells, and quercetin attenuated these effects.	Quercetin	161-170	tight junction protein 1	Mus musculus	98-102
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	BCL2, apoptosis regulator	Rattus norvegicus	198-203
34566654-4	2021	Interestingly, quercetin suppressed MC-LR-induced phosphorylation of protein kinase B (AKT).	Quercetin	15-24	thymoma viral proto-oncogene 1	Mus musculus	87-90
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	interleukin 6	Rattus norvegicus	143-147
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	androgen receptor	Rattus norvegicus	231-233
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	natriuretic peptide C	Rattus norvegicus	262-265
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	natriuretic peptide receptor 2	Rattus norvegicus	268-272
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	androgen receptor	Rattus norvegicus	322-324
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	natriuretic peptide C	Rattus norvegicus	355-358
34538551-9	2022	RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation.	Quercetin	33-42	natriuretic peptide receptor 2	Rattus norvegicus	363-367
34232231-0	2021	Investigation into the mechanisms of quercetin-3-O-glucuronide inhibiting alpha-glucosidase activity and non-enzymatic glycation by spectroscopy and molecular docking.	Quercetin	37-46	sucrase-isomaltase	Homo sapiens	74-91
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	C-X-C motif chemokine receptor 4	Homo sapiens	222-227
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	intercellular adhesion molecule 1	Homo sapiens	229-234
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	C-X-C motif chemokine ligand 8	Homo sapiens	236-241
34498538-0	2022	Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis.	Quercetin	0-9	transgelin 2	Homo sapiens	62-68
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	C-X-C motif chemokine ligand 10	Homo sapiens	243-249
34091674-10	2021	In addition, after 6 wk of quercetin administration, the expressions of GLO I/II and AR in the liver and kidney were significantly upregulated to promote MGO detoxification compared with MGO-treated mice.	Quercetin	27-36	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	85-87
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	interleukin 6	Homo sapiens	251-254
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	interleukin 2	Homo sapiens	256-259
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	C-C motif chemokine ligand 2	Homo sapiens	261-265
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	interleukin 1 beta	Homo sapiens	267-271
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	interleukin 4	Homo sapiens	273-276
34493195-7	2022	RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients.	Quercetin	101-110	interferon gamma	Homo sapiens	278-282
34495165-0	2021	Enhancement of Annexin V in response to combination of epigallocatechin gallate and quercetin as a potent arrest the cell cycle of colorectal cancer.	Quercetin	84-93	annexin A5	Homo sapiens	15-24
34495165-6	2021	Data showed a significant elevation in the annexin V at 100 microg/mL EGCG(25.85%) and 150 microg/mL quercetin (48.35%).	Quercetin	101-110	annexin A5	Homo sapiens	43-52
34824739-5	2021	The present in silico study evaluated the binding affinities of some natural products (resveratrol, xylopic acid, ellagic acid, kaempferol, and quercetin) to human angiotensin-converting enzyme 2 and coronavirus (SARS-CoV-2) main protease compared to chloroquine, an inhibitor known to prevent cellular entry and replication of the coronavirus.	Quercetin	144-153	angiotensin converting enzyme 2	Homo sapiens	164-195
34479552-11	2021	CONCLUSIONS: Luteoklin, quercetin, kaempferol and other active compounds in Epicedium can regulate multiple signaling pathways and targets such as IL6, AKT1, and EGF, therefore playing therapeutic roles in depression.	Quercetin	24-33	interleukin 6	Homo sapiens	147-150
34479552-11	2021	CONCLUSIONS: Luteoklin, quercetin, kaempferol and other active compounds in Epicedium can regulate multiple signaling pathways and targets such as IL6, AKT1, and EGF, therefore playing therapeutic roles in depression.	Quercetin	24-33	AKT serine/threonine kinase 1	Homo sapiens	152-156
34479552-11	2021	CONCLUSIONS: Luteoklin, quercetin, kaempferol and other active compounds in Epicedium can regulate multiple signaling pathways and targets such as IL6, AKT1, and EGF, therefore playing therapeutic roles in depression.	Quercetin	24-33	epidermal growth factor	Homo sapiens	162-165
34574194-5	2021	Some of these compounds (e.g., curcumin, gallic acid or quercetin) already showed capacity to limit the infection of viruses by inhibiting entry into the cell through its binding to protein Spike, regulating the expression of angiotensin-converting enzyme 2, disrupting the replication in cells by inhibition of viral proteases, and/or suppressing and modulating the host"s immune response.	Quercetin	56-65	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	190-195
34574194-5	2021	Some of these compounds (e.g., curcumin, gallic acid or quercetin) already showed capacity to limit the infection of viruses by inhibiting entry into the cell through its binding to protein Spike, regulating the expression of angiotensin-converting enzyme 2, disrupting the replication in cells by inhibition of viral proteases, and/or suppressing and modulating the host"s immune response.	Quercetin	56-65	angiotensin converting enzyme 2	Homo sapiens	226-257
34119131-1	2021	The aim of the study was to investigate the effects of cross-linkers on quercetin (QUE) absorption characteristics of QUE-loaded chitosan nanoparticles (CS-NPs).	Quercetin	72-81	citrate synthase	Homo sapiens	153-155
34246189-0	2021	Quercetin alleviates cadmium chloride-induced renal damage in rats by suppressing endoplasmic reticulum stress through SIRT1-dependent deacetylation of Xbp-1s and eIF2alpha.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	119-124
34246189-0	2021	Quercetin alleviates cadmium chloride-induced renal damage in rats by suppressing endoplasmic reticulum stress through SIRT1-dependent deacetylation of Xbp-1s and eIF2alpha.	Quercetin	0-9	eukaryotic translation initiation factor 2A	Rattus norvegicus	163-172
34198048-5	2021	Moreover, through modulation of a number of proteins such as NF-kB, PARP, STAT3, Bax, Bcl-2, COX2, and cytokines, quercetin has beneficial effects in neurodegenerative disorders, liver diseases and diabetes.	Quercetin	114-123	collagen type XI alpha 2 chain	Homo sapiens	68-72
34198048-5	2021	Moreover, through modulation of a number of proteins such as NF-kB, PARP, STAT3, Bax, Bcl-2, COX2, and cytokines, quercetin has beneficial effects in neurodegenerative disorders, liver diseases and diabetes.	Quercetin	114-123	signal transducer and activator of transcription 3	Homo sapiens	74-79
34198048-5	2021	Moreover, through modulation of a number of proteins such as NF-kB, PARP, STAT3, Bax, Bcl-2, COX2, and cytokines, quercetin has beneficial effects in neurodegenerative disorders, liver diseases and diabetes.	Quercetin	114-123	BCL2 associated X, apoptosis regulator	Homo sapiens	81-84
34198048-5	2021	Moreover, through modulation of a number of proteins such as NF-kB, PARP, STAT3, Bax, Bcl-2, COX2, and cytokines, quercetin has beneficial effects in neurodegenerative disorders, liver diseases and diabetes.	Quercetin	114-123	BCL2 apoptosis regulator	Homo sapiens	86-91
34198048-5	2021	Moreover, through modulation of a number of proteins such as NF-kB, PARP, STAT3, Bax, Bcl-2, COX2, and cytokines, quercetin has beneficial effects in neurodegenerative disorders, liver diseases and diabetes.	Quercetin	114-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-97
34198048-6	2021	PI3K/AKT is the mostly linked pathway with beneficial effects of quercetin.	Quercetin	65-74	AKT serine/threonine kinase 1	Homo sapiens	5-8
34119131-1	2021	The aim of the study was to investigate the effects of cross-linkers on quercetin (QUE) absorption characteristics of QUE-loaded chitosan nanoparticles (CS-NPs).	Quercetin	83-86	citrate synthase	Homo sapiens	153-155
34189998-1	2021	AIM: To synthesize quercetin-CAPE co-loaded poly(lactic-co-glycolic-acid) (PLGA) nanoparticles (QuCaNP) and investigate their anti-cancer activity on human colorectal carcinoma HT-29 cells.	Quercetin	19-28	structural maintenance of chromosomes 2	Homo sapiens	29-33
34303829-7	2021	Inhibition of TNF production could be mimicked by zinc ionophore quercetin, but not by primaquine, a chloroquine analog with low affinity for heme.	Quercetin	65-74	tumor necrosis factor	Mus musculus	14-17
34091174-1	2021	Our earlier studies show that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro and in vivo by the presence of certain naturally-occurring flavonoids such as quercetin and myricetin, which serve as reducing cosubstrates.	Quercetin	204-213	prostaglandin-endoperoxide synthase 1	Homo sapiens	57-79
34091174-1	2021	Our earlier studies show that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro and in vivo by the presence of certain naturally-occurring flavonoids such as quercetin and myricetin, which serve as reducing cosubstrates.	Quercetin	204-213	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	81-86
34159683-4	2021	Thus, we have comprehensively searched and summarized the different targets of quercetin in different stages of liver diseases and concluded that quercetin inhibited inflammation of the liver mainly through NF-kappaB/TLR/NLRP3, reduced PI3K/Nrf2-mediated oxidative stress, mTOR activation in autophagy, and inhibited the expression of apoptotic factors associated with the development of liver diseases.	Quercetin	79-88	NLR family pyrin domain containing 3	Homo sapiens	221-226
34091174-1	2021	Our earlier studies show that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro and in vivo by the presence of certain naturally-occurring flavonoids such as quercetin and myricetin, which serve as reducing cosubstrates.	Quercetin	204-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
34091174-3	2021	In the present study, quercetin is used as a representative model compound to investigate the chemical mechanism by which the peroxidase activity of human COX-1 and COX-2 is reactivated after each catalytic cycle.	Quercetin	22-31	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	155-160
34091174-3	2021	In the present study, quercetin is used as a representative model compound to investigate the chemical mechanism by which the peroxidase activity of human COX-1 and COX-2 is reactivated after each catalytic cycle.	Quercetin	22-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
34091174-4	2021	Molecular docking and quantum mechanics calculations are carried out to probe the interactions of quercetin with the peroxidase sites of COX-1/2 and the reactivation mechanism.	Quercetin	98-107	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	137-144
34091174-6	2021	While quercetin contains several phenolic hydroxyl groups, it is found that only the C-3"-OH group can effectively donate an electron for the reduction of heme because it not only can bind closely and tightly inside the peroxidase sites of COX-1/2, but it can also facilely donate an electron to heme Fe ion.	Quercetin	6-15	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	240-247
34091174-7	2021	This investigation provides a mechanistic explanation for the chemical process by which quercetin reactivates COX-1/2 peroxidases.	Quercetin	88-97	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	110-117
34159683-5	2021	In addition, quercetin showed different mechanisms of action at different stages of liver diseases, including the regulation of PPAR, UCP, and PLIN2-related factors via brown fat activation in liver steatosis.	Quercetin	13-22	perilipin 2	Homo sapiens	143-148
34159683-4	2021	Thus, we have comprehensively searched and summarized the different targets of quercetin in different stages of liver diseases and concluded that quercetin inhibited inflammation of the liver mainly through NF-kappaB/TLR/NLRP3, reduced PI3K/Nrf2-mediated oxidative stress, mTOR activation in autophagy, and inhibited the expression of apoptotic factors associated with the development of liver diseases.	Quercetin	79-88	NFE2 like bZIP transcription factor 2	Homo sapiens	241-245
34159683-4	2021	Thus, we have comprehensively searched and summarized the different targets of quercetin in different stages of liver diseases and concluded that quercetin inhibited inflammation of the liver mainly through NF-kappaB/TLR/NLRP3, reduced PI3K/Nrf2-mediated oxidative stress, mTOR activation in autophagy, and inhibited the expression of apoptotic factors associated with the development of liver diseases.	Quercetin	79-88	mechanistic target of rapamycin kinase	Homo sapiens	273-277
34159683-4	2021	Thus, we have comprehensively searched and summarized the different targets of quercetin in different stages of liver diseases and concluded that quercetin inhibited inflammation of the liver mainly through NF-kappaB/TLR/NLRP3, reduced PI3K/Nrf2-mediated oxidative stress, mTOR activation in autophagy, and inhibited the expression of apoptotic factors associated with the development of liver diseases.	Quercetin	146-155	NLR family pyrin domain containing 3	Homo sapiens	221-226
34159683-4	2021	Thus, we have comprehensively searched and summarized the different targets of quercetin in different stages of liver diseases and concluded that quercetin inhibited inflammation of the liver mainly through NF-kappaB/TLR/NLRP3, reduced PI3K/Nrf2-mediated oxidative stress, mTOR activation in autophagy, and inhibited the expression of apoptotic factors associated with the development of liver diseases.	Quercetin	146-155	NFE2 like bZIP transcription factor 2	Homo sapiens	241-245
34159683-4	2021	Thus, we have comprehensively searched and summarized the different targets of quercetin in different stages of liver diseases and concluded that quercetin inhibited inflammation of the liver mainly through NF-kappaB/TLR/NLRP3, reduced PI3K/Nrf2-mediated oxidative stress, mTOR activation in autophagy, and inhibited the expression of apoptotic factors associated with the development of liver diseases.	Quercetin	146-155	mechanistic target of rapamycin kinase	Homo sapiens	273-277
34159683-5	2021	In addition, quercetin showed different mechanisms of action at different stages of liver diseases, including the regulation of PPAR, UCP, and PLIN2-related factors via brown fat activation in liver steatosis.	Quercetin	13-22	peroxisome proliferator activated receptor alpha	Homo sapiens	128-132
34490051-4	2021	After the quercetin loading in ethanol, BET surface area and BJH pore volume of porous lactose were reduced to 28.8735 +- 0.3526 m2/g and 0.073315 cc/g, respectively.	Quercetin	10-19	delta/notch like EGF repeat containing	Homo sapiens	40-43
34147524-0	2021	Novel quercetin encapsulated chitosan functionalized copper oxide nanoparticles as anti-breast cancer agent via regulating p53 in rat model.	Quercetin	6-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	123-126
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	mitogen-activated protein kinase 1	Homo sapiens	625-629
34450426-6	2021	However, dietary quercetin prevented a marked increase in the Bax, caspase3 and caspase9 transcript abundances that were induced by TPT.	Quercetin	17-26	BCL2 associated X, apoptosis regulator a	Danio rerio	62-65
34450426-6	2021	However, dietary quercetin prevented a marked increase in the Bax, caspase3 and caspase9 transcript abundances that were induced by TPT.	Quercetin	17-26	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	67-75
34450426-6	2021	However, dietary quercetin prevented a marked increase in the Bax, caspase3 and caspase9 transcript abundances that were induced by TPT.	Quercetin	17-26	caspase 9, apoptosis-related cysteine peptidase	Danio rerio	80-88
34549711-2	2021	METHODS: Quercetin and HF-related targets were obtained using TCMSP, PharmMapper, CTD and GeneCards databases, and quercetin-HF intersection targets were obtained through the online website Venn; the protein interaction network was constructed and imported into Cytoscape 3.7.2 to identify the core targets of quercetin in the treatment of HF.GO and KEGG pathway enrichment analyses were performed using R package, and molecular docking was performed using Auto Dock Vina.The protein levels of AKT1, phospho-AKT(Ser473), eNOS, MMP9, and caspase-3 in quercetin-treated HF cell models were detected using protein immunoblotting.	Quercetin	9-18	AKT serine/threonine kinase 1	Homo sapiens	494-498
34549711-2	2021	METHODS: Quercetin and HF-related targets were obtained using TCMSP, PharmMapper, CTD and GeneCards databases, and quercetin-HF intersection targets were obtained through the online website Venn; the protein interaction network was constructed and imported into Cytoscape 3.7.2 to identify the core targets of quercetin in the treatment of HF.GO and KEGG pathway enrichment analyses were performed using R package, and molecular docking was performed using Auto Dock Vina.The protein levels of AKT1, phospho-AKT(Ser473), eNOS, MMP9, and caspase-3 in quercetin-treated HF cell models were detected using protein immunoblotting.	Quercetin	310-319	AKT serine/threonine kinase 1	Homo sapiens	494-498
34549711-2	2021	METHODS: Quercetin and HF-related targets were obtained using TCMSP, PharmMapper, CTD and GeneCards databases, and quercetin-HF intersection targets were obtained through the online website Venn; the protein interaction network was constructed and imported into Cytoscape 3.7.2 to identify the core targets of quercetin in the treatment of HF.GO and KEGG pathway enrichment analyses were performed using R package, and molecular docking was performed using Auto Dock Vina.The protein levels of AKT1, phospho-AKT(Ser473), eNOS, MMP9, and caspase-3 in quercetin-treated HF cell models were detected using protein immunoblotting.	Quercetin	310-319	AKT serine/threonine kinase 1	Homo sapiens	508-511
34549711-2	2021	METHODS: Quercetin and HF-related targets were obtained using TCMSP, PharmMapper, CTD and GeneCards databases, and quercetin-HF intersection targets were obtained through the online website Venn; the protein interaction network was constructed and imported into Cytoscape 3.7.2 to identify the core targets of quercetin in the treatment of HF.GO and KEGG pathway enrichment analyses were performed using R package, and molecular docking was performed using Auto Dock Vina.The protein levels of AKT1, phospho-AKT(Ser473), eNOS, MMP9, and caspase-3 in quercetin-treated HF cell models were detected using protein immunoblotting.	Quercetin	310-319	nitric oxide synthase 3	Homo sapiens	521-525
34707441-7	2021	D2 with quercetin showed a positive effect and inhibited vit.	Quercetin	8-17	vitrin	Homo sapiens	57-60
34707441-16	2021	Quercetin exerted vit.	Quercetin	0-9	vitrin	Homo sapiens	18-21
34707441-18	2021	Conclusively, quercetin can be an effective way to reduce temperature and pH induced degradation of vit.	Quercetin	14-23	vitrin	Homo sapiens	100-103
34572484-0	2021	Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin.	Quercetin	73-82	epidermal growth factor receptor	Homo sapiens	50-54
34572484-5	2021	As quercetin was recently shown to inhibit AXL, quercetin may be effective in treating NSCLC cells harboring the EGFR C797S mutation.	Quercetin	3-12	AXL receptor tyrosine kinase	Homo sapiens	43-46
34572484-5	2021	As quercetin was recently shown to inhibit AXL, quercetin may be effective in treating NSCLC cells harboring the EGFR C797S mutation.	Quercetin	48-57	AXL receptor tyrosine kinase	Homo sapiens	43-46
34572484-5	2021	As quercetin was recently shown to inhibit AXL, quercetin may be effective in treating NSCLC cells harboring the EGFR C797S mutation.	Quercetin	48-57	epidermal growth factor receptor	Homo sapiens	113-117
34572484-6	2021	In this work, the cytotoxic effects of quercetin and its ability to inhibit tumor growth were examined in TKI-resistant NSCLC cells harboring the EGFR C797S mutation.	Quercetin	39-48	epidermal growth factor receptor	Homo sapiens	146-150
34572484-7	2021	We demonstrated that quercetin exhibited potent cytotoxic effects on NSCLC cells harboring the EGFR C797S mutation by inhibiting AXL and inducing apoptosis.	Quercetin	21-30	epidermal growth factor receptor	Homo sapiens	95-99
34572484-7	2021	We demonstrated that quercetin exhibited potent cytotoxic effects on NSCLC cells harboring the EGFR C797S mutation by inhibiting AXL and inducing apoptosis.	Quercetin	21-30	AXL receptor tyrosine kinase	Homo sapiens	129-132
34572484-8	2021	Quercetin inhibited the tumor growth of xenografted NSCLC cells harboring the EGFR C797S mutation and appeared to act synergistically with brigatinib to inhibit of tumor growth in vivo.	Quercetin	0-9	epidermal growth factor receptor	Homo sapiens	78-82
34572484-9	2021	In summary, herein, we revealed that quercetin is an effective inhibitor for the treatment of non-small-cell lung cancer harboring the EGFR C797S mutation.	Quercetin	37-46	epidermal growth factor receptor	Homo sapiens	135-139
34549711-2	2021	METHODS: Quercetin and HF-related targets were obtained using TCMSP, PharmMapper, CTD and GeneCards databases, and quercetin-HF intersection targets were obtained through the online website Venn; the protein interaction network was constructed and imported into Cytoscape 3.7.2 to identify the core targets of quercetin in the treatment of HF.GO and KEGG pathway enrichment analyses were performed using R package, and molecular docking was performed using Auto Dock Vina.The protein levels of AKT1, phospho-AKT(Ser473), eNOS, MMP9, and caspase-3 in quercetin-treated HF cell models were detected using protein immunoblotting.	Quercetin	310-319	matrix metallopeptidase 9	Homo sapiens	527-531
34549711-2	2021	METHODS: Quercetin and HF-related targets were obtained using TCMSP, PharmMapper, CTD and GeneCards databases, and quercetin-HF intersection targets were obtained through the online website Venn; the protein interaction network was constructed and imported into Cytoscape 3.7.2 to identify the core targets of quercetin in the treatment of HF.GO and KEGG pathway enrichment analyses were performed using R package, and molecular docking was performed using Auto Dock Vina.The protein levels of AKT1, phospho-AKT(Ser473), eNOS, MMP9, and caspase-3 in quercetin-treated HF cell models were detected using protein immunoblotting.	Quercetin	310-319	caspase 3	Homo sapiens	537-546
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	26-35	AKT serine/threonine kinase 1	Homo sapiens	63-67
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	26-35	caspase 3	Homo sapiens	69-74
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	26-35	mitogen-activated protein kinase 1	Homo sapiens	76-81
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	26-35	matrix metallopeptidase 9	Homo sapiens	83-87
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	26-35	mitogen-activated protein kinase 8	Homo sapiens	93-98
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	AKT serine/threonine kinase 1	Homo sapiens	63-67
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	caspase 3	Homo sapiens	69-74
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	mitogen-activated protein kinase 1	Homo sapiens	76-81
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	matrix metallopeptidase 9	Homo sapiens	83-87
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	mitogen-activated protein kinase 8	Homo sapiens	93-98
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	AKT serine/threonine kinase 1	Homo sapiens	574-577
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	AKT serine/threonine kinase 1	Homo sapiens	880-884
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	AKT serine/threonine kinase 1	Homo sapiens	894-897
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	nitric oxide synthase 3	Homo sapiens	908-912
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	matrix metallopeptidase 9	Homo sapiens	914-918
34549711-3	2021	RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01).	Quercetin	205-214	caspase 3	Homo sapiens	923-932
34549711-4	2021	CONCLUSION: Quercetin improves the pathological changes in HF possibly by regulating the AKT1-eNOS-MMP9 pathway to inhibit cell apoptosis.	Quercetin	12-21	AKT serine/threonine kinase 1	Homo sapiens	89-93
34457029-0	2021	Quercetin Protects H9c2 Cardiomyocytes against Oxygen-Glucose Deprivation/Reoxygenation-Induced Oxidative Stress and Mitochondrial Apoptosis by Regulating the ERK1/2/DRP1 Signaling Pathway.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	159-165
34549711-4	2021	CONCLUSION: Quercetin improves the pathological changes in HF possibly by regulating the AKT1-eNOS-MMP9 pathway to inhibit cell apoptosis.	Quercetin	12-21	nitric oxide synthase 3	Homo sapiens	94-98
34549711-4	2021	CONCLUSION: Quercetin improves the pathological changes in HF possibly by regulating the AKT1-eNOS-MMP9 pathway to inhibit cell apoptosis.	Quercetin	12-21	matrix metallopeptidase 9	Homo sapiens	99-103
34457029-0	2021	Quercetin Protects H9c2 Cardiomyocytes against Oxygen-Glucose Deprivation/Reoxygenation-Induced Oxidative Stress and Mitochondrial Apoptosis by Regulating the ERK1/2/DRP1 Signaling Pathway.	Quercetin	0-9	utrophin	Homo sapiens	166-170
34445644-4	2021	In this work, we show that the mechanisms underlying the beneficial effects of RSV and QRC against inflammation in liver damage in our MS model are due to the activation of novel pathways which have not been previously described such as the downregulation of the expression of toll-like receptor 4 (TLR4), neutrophil elastase (NE) and purinergic receptor P2Y2.	Quercetin	87-90	toll like receptor 4	Homo sapiens	277-297
34445644-4	2021	In this work, we show that the mechanisms underlying the beneficial effects of RSV and QRC against inflammation in liver damage in our MS model are due to the activation of novel pathways which have not been previously described such as the downregulation of the expression of toll-like receptor 4 (TLR4), neutrophil elastase (NE) and purinergic receptor P2Y2.	Quercetin	87-90	toll like receptor 4	Homo sapiens	299-303
34439499-8	2021	The expression of genes Srebf1, Ppara, Cyp51, Scd1, and Fasn was downregulated by quercetin supplementation.	Quercetin	82-91	sterol regulatory element binding transcription factor 1	Mus musculus	24-30
34408403-10	2021	Results: Quercetin at 5 muM strongly activated NF-E2-related factor 2 (NRF2) signaling, alleviated oxidative damage and enhanced the antioxidant capacity of hPDLCs.	Quercetin	9-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	47-69
34408403-10	2021	Results: Quercetin at 5 muM strongly activated NF-E2-related factor 2 (NRF2) signaling, alleviated oxidative damage and enhanced the antioxidant capacity of hPDLCs.	Quercetin	9-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	71-75
34408403-12	2021	Finally, quercetin activated NRF2 signaling in the periodontal ligaments, reduced the OS level of mice with periodontitis, and slowed the absorption of alveolar bone in vivo.	Quercetin	9-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	29-33
34408403-13	2021	Conclusion: Quercetin can increase the antioxidant capacity of PDLCs and reduce OS damage by activating the NRF2 signaling pathway, which alleviates alveolar bone loss in periodontitis.	Quercetin	12-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
34549702-10	2021	Molecular docking showed that quercetin, luteolin and kaempferol could bind to Akt1, PIK3R1 and MAPK1, respectively.	Quercetin	30-39	AKT serine/threonine kinase 1	Rattus norvegicus	79-83
34549702-10	2021	Molecular docking showed that quercetin, luteolin and kaempferol could bind to Akt1, PIK3R1 and MAPK1, respectively.	Quercetin	30-39	phosphoinositide-3-kinase regulatory subunit 1	Rattus norvegicus	85-91
34549702-10	2021	Molecular docking showed that quercetin, luteolin and kaempferol could bind to Akt1, PIK3R1 and MAPK1, respectively.	Quercetin	30-39	mitogen activated protein kinase 1	Rattus norvegicus	96-101
34439499-6	2021	Diabetes-related plasma biomarkers insulin, leptin, resistin, and glucagon were significantly reduced by quercetin supplementation.	Quercetin	105-114	leptin	Mus musculus	44-50
34439499-6	2021	Diabetes-related plasma biomarkers insulin, leptin, resistin, and glucagon were significantly reduced by quercetin supplementation.	Quercetin	105-114	glucagon	Mus musculus	66-74
34439499-8	2021	The expression of genes Srebf1, Ppara, Cyp51, Scd1, and Fasn was downregulated by quercetin supplementation.	Quercetin	82-91	peroxisome proliferator activated receptor alpha	Mus musculus	32-37
34439499-8	2021	The expression of genes Srebf1, Ppara, Cyp51, Scd1, and Fasn was downregulated by quercetin supplementation.	Quercetin	82-91	cytochrome P450, family 51	Mus musculus	39-44
34439499-8	2021	The expression of genes Srebf1, Ppara, Cyp51, Scd1, and Fasn was downregulated by quercetin supplementation.	Quercetin	82-91	stearoyl-Coenzyme A desaturase 1	Mus musculus	46-50
34439499-8	2021	The expression of genes Srebf1, Ppara, Cyp51, Scd1, and Fasn was downregulated by quercetin supplementation.	Quercetin	82-91	fatty acid synthase	Mus musculus	56-60
34338101-0	2022	Quercetin Inhibits the Epithelial to Mesenchymal Transition through Suppressing Akt Mediated Nuclear Translocation of beta-Catenin in Lung Cancer Cell Line.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	80-83
34361114-8	2021	The results of the present study demonstrate that pDCs can respond to LPS and that quercetin exposure modulates soluble factors release through the same molecular pathway used by mDCs (Slpi, Hmox1, and AP-1).	Quercetin	83-92	secretory leukocyte peptidase inhibitor	Homo sapiens	185-189
34361114-8	2021	The results of the present study demonstrate that pDCs can respond to LPS and that quercetin exposure modulates soluble factors release through the same molecular pathway used by mDCs (Slpi, Hmox1, and AP-1).	Quercetin	83-92	heme oxygenase 1	Homo sapiens	191-196
34361114-8	2021	The results of the present study demonstrate that pDCs can respond to LPS and that quercetin exposure modulates soluble factors release through the same molecular pathway used by mDCs (Slpi, Hmox1, and AP-1).	Quercetin	83-92	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-206
34338101-0	2022	Quercetin Inhibits the Epithelial to Mesenchymal Transition through Suppressing Akt Mediated Nuclear Translocation of beta-Catenin in Lung Cancer Cell Line.	Quercetin	0-9	catenin beta 1	Homo sapiens	118-130
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Quercetin	61-70	microtubule associated protein tau	Homo sapiens	301-304
34149888-0	2021	Inhibitory effects of quercetin and its major metabolite quercetin-3-O-beta-D-glucoside on human UDP-glucuronosyltransferase 1A isoforms by liquid chromatography-tandem mass spectrometry.	Quercetin	22-31	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	97-127
34149888-4	2021	The present study aimed to investigate the inhibitory profile of quercetin and Q3GA on recombinant UGT1A isoforms in vitro.	Quercetin	65-74	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	99-104
34149888-6	2021	Preliminary screening experiments indicated that quercetin exhibited stronger inhibitory effects on UGT1A1, UGT1A3, UGT1A6 and UGT1A9 enzymes than Q3GA.	Quercetin	49-58	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	100-106
34149888-6	2021	Preliminary screening experiments indicated that quercetin exhibited stronger inhibitory effects on UGT1A1, UGT1A3, UGT1A6 and UGT1A9 enzymes than Q3GA.	Quercetin	49-58	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	108-114
34149888-6	2021	Preliminary screening experiments indicated that quercetin exhibited stronger inhibitory effects on UGT1A1, UGT1A3, UGT1A6 and UGT1A9 enzymes than Q3GA.	Quercetin	49-58	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	116-122
34149888-6	2021	Preliminary screening experiments indicated that quercetin exhibited stronger inhibitory effects on UGT1A1, UGT1A3, UGT1A6 and UGT1A9 enzymes than Q3GA.	Quercetin	49-58	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	127-133
34149888-7	2021	Kinetic experiments were performed to characterize the type of inhibition caused by quercetin and Q3GA towards these UGT isoforms.	Quercetin	84-93	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	117-120
34149888-8	2021	Quercetin exerted non-competitive inhibition on UGT1A1 and UGT1A6, with half maximal inhibitory concentration (IC50) values of 7.47 and 7.07 microM and inhibition kinetic parameter (Ki) values of 2.18 and 28.87 microM, respectively.	Quercetin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	48-54
34149888-8	2021	Quercetin exerted non-competitive inhibition on UGT1A1 and UGT1A6, with half maximal inhibitory concentration (IC50) values of 7.47 and 7.07 microM and inhibition kinetic parameter (Ki) values of 2.18 and 28.87 microM, respectively.	Quercetin	0-9	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	59-65
34149888-9	2021	Quercetin also exhibited competitive inhibition on UGT1A3 and UGT1A9, with IC50 values of 10.58 and 2.81 microM and Ki values of 1.60 and 0.51 microM, respectively.	Quercetin	0-9	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	51-57
34149888-9	2021	Quercetin also exhibited competitive inhibition on UGT1A3 and UGT1A9, with IC50 values of 10.58 and 2.81 microM and Ki values of 1.60 and 0.51 microM, respectively.	Quercetin	0-9	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	62-68
34149888-11	2021	In the present study, quercetin was a moderate inhibitor of UGT1A1 and UGT1A3, a weak inhibitor of UGT1A6, and a strong inhibitor on UGT1A9.	Quercetin	22-31	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
34149888-11	2021	In the present study, quercetin was a moderate inhibitor of UGT1A1 and UGT1A3, a weak inhibitor of UGT1A6, and a strong inhibitor on UGT1A9.	Quercetin	22-31	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	71-77
34149888-11	2021	In the present study, quercetin was a moderate inhibitor of UGT1A1 and UGT1A3, a weak inhibitor of UGT1A6, and a strong inhibitor on UGT1A9.	Quercetin	22-31	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	99-105
34149888-11	2021	In the present study, quercetin was a moderate inhibitor of UGT1A1 and UGT1A3, a weak inhibitor of UGT1A6, and a strong inhibitor on UGT1A9.	Quercetin	22-31	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	133-139
34149888-12	2021	The results of the present study suggested potential HDIs that may occur following quercetin co-administration with drugs that are mainly metabolized by UGT1A1, UGT1A3 and UGT1A9 enzymes.	Quercetin	83-92	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	153-159
34135081-6	2021	Broader clearance of senescent cells using the oral senolytic combination Dasatinib and Quercetin in C57BL/6 RAS mice was more effective in clearing p21 (Cdkn1a)-positive cells and alleviating renal dysfunction and damage.	Quercetin	88-97	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	149-152
34135081-6	2021	Broader clearance of senescent cells using the oral senolytic combination Dasatinib and Quercetin in C57BL/6 RAS mice was more effective in clearing p21 (Cdkn1a)-positive cells and alleviating renal dysfunction and damage.	Quercetin	88-97	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	154-160
34554677-5	2021	Our results showed that berberine and quercetin effectively inhibited the proliferation and migration of hypoxia-induced PASMCs in a manner likely to be mediated by the suppression of MAPK1, NADPH oxidase 4 (NOX4), and cytochrome P450 1B1 (CYP1B1) expression.	Quercetin	38-47	mitogen activated protein kinase 1	Rattus norvegicus	184-189
34554677-5	2021	Our results showed that berberine and quercetin effectively inhibited the proliferation and migration of hypoxia-induced PASMCs in a manner likely to be mediated by the suppression of MAPK1, NADPH oxidase 4 (NOX4), and cytochrome P450 1B1 (CYP1B1) expression.	Quercetin	38-47	NADPH oxidase 4	Rattus norvegicus	191-206
34554677-5	2021	Our results showed that berberine and quercetin effectively inhibited the proliferation and migration of hypoxia-induced PASMCs in a manner likely to be mediated by the suppression of MAPK1, NADPH oxidase 4 (NOX4), and cytochrome P450 1B1 (CYP1B1) expression.	Quercetin	38-47	NADPH oxidase 4	Rattus norvegicus	208-212
34554677-5	2021	Our results showed that berberine and quercetin effectively inhibited the proliferation and migration of hypoxia-induced PASMCs in a manner likely to be mediated by the suppression of MAPK1, NADPH oxidase 4 (NOX4), and cytochrome P450 1B1 (CYP1B1) expression.	Quercetin	38-47	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	219-238
34554677-5	2021	Our results showed that berberine and quercetin effectively inhibited the proliferation and migration of hypoxia-induced PASMCs in a manner likely to be mediated by the suppression of MAPK1, NADPH oxidase 4 (NOX4), and cytochrome P450 1B1 (CYP1B1) expression.	Quercetin	38-47	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	240-246
34149888-12	2021	The results of the present study suggested potential HDIs that may occur following quercetin co-administration with drugs that are mainly metabolized by UGT1A1, UGT1A3 and UGT1A9 enzymes.	Quercetin	83-92	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	161-167
34149888-12	2021	The results of the present study suggested potential HDIs that may occur following quercetin co-administration with drugs that are mainly metabolized by UGT1A1, UGT1A3 and UGT1A9 enzymes.	Quercetin	83-92	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	172-178
34349878-11	2021	The activities and concentrations of MMP-2 and MMP-9 were also decreased significantly as the concentration of quercetin increased.	Quercetin	111-120	matrix metallopeptidase 9	Mus musculus	47-52
34349878-3	2021	Therefore, this study investigated the role of quercetin on adipogenesis in 3T3-L1 cells, acting through matrix metalloproteinases (MMPs).	Quercetin	47-56	matrix metallopeptidase 2	Mus musculus	132-136
34349878-12	2021	CONCLUSIONS: The results confirm that quercetin inhibits adipose tissue differentiation and fat accumulation in 3T3-L1 cells, which could occur through inhibition of the angiogenesis process related to MMPs.	Quercetin	38-47	matrix metallopeptidase 2	Mus musculus	202-206
34349878-9	2021	RESULTS: Quercetin treatment suppressed fat accumulation and the expressions of adipocyte differentiation-related genes (C/EBPalpha, C/EBPbeta, PPAR-gamma, and aP2) in a concentration-dependent manner in 3T3-L1 cells.	Quercetin	9-18	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	121-131
34349878-9	2021	RESULTS: Quercetin treatment suppressed fat accumulation and the expressions of adipocyte differentiation-related genes (C/EBPalpha, C/EBPbeta, PPAR-gamma, and aP2) in a concentration-dependent manner in 3T3-L1 cells.	Quercetin	9-18	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	133-142
34082381-0	2021	Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	93-98
34349878-9	2021	RESULTS: Quercetin treatment suppressed fat accumulation and the expressions of adipocyte differentiation-related genes (C/EBPalpha, C/EBPbeta, PPAR-gamma, and aP2) in a concentration-dependent manner in 3T3-L1 cells.	Quercetin	9-18	peroxisome proliferator activated receptor gamma	Mus musculus	144-154
34349878-9	2021	RESULTS: Quercetin treatment suppressed fat accumulation and the expressions of adipocyte differentiation-related genes (C/EBPalpha, C/EBPbeta, PPAR-gamma, and aP2) in a concentration-dependent manner in 3T3-L1 cells.	Quercetin	9-18	fatty acid binding protein 4, adipocyte	Mus musculus	160-163
34349878-10	2021	Quercetin treatments reduced the mRNA expressions of VEGF-alpha, VEGFR-2, MMP-2, and MMP-9 in 3T3-L1 cells.	Quercetin	0-9	vascular endothelial growth factor A	Mus musculus	53-63
34349878-10	2021	Quercetin treatments reduced the mRNA expressions of VEGF-alpha, VEGFR-2, MMP-2, and MMP-9 in 3T3-L1 cells.	Quercetin	0-9	kinase insert domain protein receptor	Mus musculus	65-72
34349878-10	2021	Quercetin treatments reduced the mRNA expressions of VEGF-alpha, VEGFR-2, MMP-2, and MMP-9 in 3T3-L1 cells.	Quercetin	0-9	matrix metallopeptidase 2	Mus musculus	74-79
34349878-10	2021	Quercetin treatments reduced the mRNA expressions of VEGF-alpha, VEGFR-2, MMP-2, and MMP-9 in 3T3-L1 cells.	Quercetin	0-9	matrix metallopeptidase 9	Mus musculus	85-90
34349878-11	2021	The activities and concentrations of MMP-2 and MMP-9 were also decreased significantly as the concentration of quercetin increased.	Quercetin	111-120	matrix metallopeptidase 2	Mus musculus	37-42
34082381-9	2021	Further IL-1beta administration blunted these neuroprotective effects of Qu in vitro and in vivo.	Quercetin	73-75	interleukin 1 alpha	Mus musculus	8-16
34385920-5	2021	Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 muM for 24 h either in the absence or presence of interferon (IFN-gamma) for 3 h to induce inflammation.	Quercetin	167-176	intercellular adhesion molecule 1	Homo sapiens	36-69
34349502-12	2021	Moreover, molecular docking suggested that quercetin, luteolin, and nobiletin combined well with JUN, TP53, and ESR1, respectively.	Quercetin	43-52	transformation related protein 53	Mus musculus	102-106
34349502-12	2021	Moreover, molecular docking suggested that quercetin, luteolin, and nobiletin combined well with JUN, TP53, and ESR1, respectively.	Quercetin	43-52	estrogen receptor 1 (alpha)	Mus musculus	112-116
34349502-13	2021	Cell experiments showed that the most important ingredient of HHS, quercetin, could inhibit the levels of inflammatory factors and phosphorylated c-Jun, as well as PI3K-Akt signaling pathway in LPS-induced RAW264.7 cells, which further confirmed the prediction by network pharmacology strategy and molecular docking.	Quercetin	67-76	jun proto-oncogene	Mus musculus	146-151
34349502-13	2021	Cell experiments showed that the most important ingredient of HHS, quercetin, could inhibit the levels of inflammatory factors and phosphorylated c-Jun, as well as PI3K-Akt signaling pathway in LPS-induced RAW264.7 cells, which further confirmed the prediction by network pharmacology strategy and molecular docking.	Quercetin	67-76	thymoma viral proto-oncogene 1	Mus musculus	169-172
34385920-5	2021	Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 muM for 24 h either in the absence or presence of interferon (IFN-gamma) for 3 h to induce inflammation.	Quercetin	167-176	intercellular adhesion molecule 1	Homo sapiens	71-77
34385920-5	2021	Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 muM for 24 h either in the absence or presence of interferon (IFN-gamma) for 3 h to induce inflammation.	Quercetin	167-176	C-C motif chemokine ligand 2	Homo sapiens	83-117
34385920-5	2021	Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 muM for 24 h either in the absence or presence of interferon (IFN-gamma) for 3 h to induce inflammation.	Quercetin	167-176	C-C motif chemokine ligand 2	Homo sapiens	119-124
34385920-13	2021	Conclusion: Our results from both in vitro and in silico studies identified that quercetin inhibited the THP-1 monocyte migration, MCP-1, and ICAM-1 and increased cholesterol efflux probably mediated via the LXR/RXR signaling pathway.	Quercetin	81-90	C-C motif chemokine ligand 2	Homo sapiens	131-136
34385920-13	2021	Conclusion: Our results from both in vitro and in silico studies identified that quercetin inhibited the THP-1 monocyte migration, MCP-1, and ICAM-1 and increased cholesterol efflux probably mediated via the LXR/RXR signaling pathway.	Quercetin	81-90	intercellular adhesion molecule 1	Homo sapiens	142-148
34385920-13	2021	Conclusion: Our results from both in vitro and in silico studies identified that quercetin inhibited the THP-1 monocyte migration, MCP-1, and ICAM-1 and increased cholesterol efflux probably mediated via the LXR/RXR signaling pathway.	Quercetin	81-90	retinoid X receptor alpha	Homo sapiens	212-215
34360703-7	2021	Some (poly)phenolics such as caffeic acid, hydroxytyrosol, resveratrol, curcumin, nordihydroguaiaretic acid (NDGA), and quercetin have been reported to reduce the formation of 5-LOX eicosanoids in vitro.	Quercetin	120-129	arachidonate 5-lipoxygenase	Homo sapiens	176-181
34451819-0	2021	Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABAA and GABAB Receptor Interaction Pathway.	Quercetin	0-9	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	105-110
34295174-0	2021	Quercetin Alleviates Osteoarthritis Progression in Rats by Suppressing Inflammation and Apoptosis via Inhibition of IRAK1/NLRP3 Signaling.	Quercetin	0-9	interleukin-1 receptor-associated kinase 1	Rattus norvegicus	116-121
34292112-5	2022	Our findings indicate that quercetin has neuroprotective effects against cerebral ischemia-reperfusion injury by protecting BBB through Sirt1 signaling pathway in MCAO rats.	Quercetin	27-36	sirtuin 1	Rattus norvegicus	136-141
34278888-0	2022	Quercetin Impairs HuR-Driven Progression and Migration of Triple Negative Breast Cancer (TNBC) Cells.	Quercetin	0-9	ELAV like RNA binding protein 1	Homo sapiens	18-21
34278888-5	2022	Quercetin treatment significantly inhibited the cytoplasmic HuR in both TNBC cell lines.	Quercetin	0-9	ELAV like RNA binding protein 1	Homo sapiens	60-63
34278888-6	2022	By using specific HuR siRNA, we established that quercetin-mediated inhibition of adhesion and migration of TNBC cells is dependent on HuR.	Quercetin	49-58	ELAV like RNA binding protein 1	Homo sapiens	18-21
34278888-6	2022	By using specific HuR siRNA, we established that quercetin-mediated inhibition of adhesion and migration of TNBC cells is dependent on HuR.	Quercetin	49-58	ELAV like RNA binding protein 1	Homo sapiens	135-138
34278888-7	2022	Upon analyzing adhesion proteins i.e., beta-catenin and CD44, we found that quercetin mediated effect on TNBC adhesion and migration was through the HuR-beta-catenin axis and CD44, independently.	Quercetin	76-85	catenin beta 1	Homo sapiens	39-51
34278888-7	2022	Upon analyzing adhesion proteins i.e., beta-catenin and CD44, we found that quercetin mediated effect on TNBC adhesion and migration was through the HuR-beta-catenin axis and CD44, independently.	Quercetin	76-85	CD44 molecule (Indian blood group)	Homo sapiens	56-60
34278888-7	2022	Upon analyzing adhesion proteins i.e., beta-catenin and CD44, we found that quercetin mediated effect on TNBC adhesion and migration was through the HuR-beta-catenin axis and CD44, independently.	Quercetin	76-85	ELAV like RNA binding protein 1	Homo sapiens	149-152
34278888-7	2022	Upon analyzing adhesion proteins i.e., beta-catenin and CD44, we found that quercetin mediated effect on TNBC adhesion and migration was through the HuR-beta-catenin axis and CD44, independently.	Quercetin	76-85	catenin beta 1	Homo sapiens	153-165
34278888-7	2022	Upon analyzing adhesion proteins i.e., beta-catenin and CD44, we found that quercetin mediated effect on TNBC adhesion and migration was through the HuR-beta-catenin axis and CD44, independently.	Quercetin	76-85	CD44 molecule (Indian blood group)	Homo sapiens	175-179
34278888-8	2022	Overall, the present results demonstrate that elevated HuR levels are associated with TNBC progression and relapse, and the ability of quercetin to inhibit cytoplasmic HuR protein provides a rationale for using it as an anticancer agent for the treatment of aggressive TNBCs.Supplemental data for this article is available online at at 10.1080/01635581.2021.1952628.	Quercetin	135-144	ELAV like RNA binding protein 1	Homo sapiens	55-58
34278888-8	2022	Overall, the present results demonstrate that elevated HuR levels are associated with TNBC progression and relapse, and the ability of quercetin to inhibit cytoplasmic HuR protein provides a rationale for using it as an anticancer agent for the treatment of aggressive TNBCs.Supplemental data for this article is available online at at 10.1080/01635581.2021.1952628.	Quercetin	135-144	ELAV like RNA binding protein 1	Homo sapiens	168-171
34278965-9	2021	Considering molecular docking, simulation, and DFT analysis of the selected compounds, notably eriodictoyl, quercetin, and diosmetin showed good potential against SARS-CoV-2 Mpro.	Quercetin	108-117	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	174-178
34295174-9	2021	Importantly, rescue experiments confirmed that quercetin inhibited IL-1beta-induced rat chondrocyte injuries in vitro by suppressing the IRAK1/NLRP3 signaling pathway.	Quercetin	47-56	interleukin 1 alpha	Rattus norvegicus	67-75
34295174-9	2021	Importantly, rescue experiments confirmed that quercetin inhibited IL-1beta-induced rat chondrocyte injuries in vitro by suppressing the IRAK1/NLRP3 signaling pathway.	Quercetin	47-56	interleukin-1 receptor-associated kinase 1	Rattus norvegicus	137-142
34295174-9	2021	Importantly, rescue experiments confirmed that quercetin inhibited IL-1beta-induced rat chondrocyte injuries in vitro by suppressing the IRAK1/NLRP3 signaling pathway.	Quercetin	47-56	NLR family, pyrin domain containing 3	Rattus norvegicus	143-148
34295174-10	2021	Conclusion: Our study indicated that quercetin inhibits IL-1beta-induced inflammation and cartilage degradation by suppressing the IRAK1/NLRP3 signaling pathway.	Quercetin	37-46	interleukin 1 alpha	Rattus norvegicus	56-64
34295174-10	2021	Conclusion: Our study indicated that quercetin inhibits IL-1beta-induced inflammation and cartilage degradation by suppressing the IRAK1/NLRP3 signaling pathway.	Quercetin	37-46	interleukin-1 receptor-associated kinase 1	Rattus norvegicus	131-136
34295174-10	2021	Conclusion: Our study indicated that quercetin inhibits IL-1beta-induced inflammation and cartilage degradation by suppressing the IRAK1/NLRP3 signaling pathway.	Quercetin	37-46	NLR family, pyrin domain containing 3	Rattus norvegicus	137-142
34292112-0	2022	Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats.	Quercetin	0-9	sirtuin 1	Rattus norvegicus	95-100
34292112-3	2022	The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway.	Quercetin	24-33	sirtuin 1	Rattus norvegicus	143-148
34292112-3	2022	The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway.	Quercetin	24-33	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
34292112-3	2022	The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway.	Quercetin	24-33	heme oxygenase 1	Rattus norvegicus	154-158
34326886-11	2021	Subsequent biological experiments verified that EH inhibits the PI3K-AKT signaling pathway through its active ingredients, quercetin, and wedelolactone, thereby inhibiting the proliferation of HCC cells and promoting the apoptosis of HCC cells.	Quercetin	123-132	AKT serine/threonine kinase 1	Homo sapiens	69-72
34326886-13	2021	Our study demonstrated that the anti-HCC proliferation activity of EH is mainly exerted by two active ingredients (quercetin and wedelolactone), which inhibit the proliferation of HCC cells (HepG2 and Huh-7) by inhibiting PI3K-AKT signaling.	Quercetin	115-124	MIR7-3 host gene	Homo sapiens	201-206
34326886-13	2021	Our study demonstrated that the anti-HCC proliferation activity of EH is mainly exerted by two active ingredients (quercetin and wedelolactone), which inhibit the proliferation of HCC cells (HepG2 and Huh-7) by inhibiting PI3K-AKT signaling.	Quercetin	115-124	AKT serine/threonine kinase 1	Homo sapiens	227-230
34295174-0	2021	Quercetin Alleviates Osteoarthritis Progression in Rats by Suppressing Inflammation and Apoptosis via Inhibition of IRAK1/NLRP3 Signaling.	Quercetin	0-9	NLR family, pyrin domain containing 3	Rattus norvegicus	122-127
34295174-7	2021	Results: Our data showed that quercetin attenuated the degeneration and erosion of articular cartilage, suppressed inflammation and apoptosis, and downregulated the levels of IRAK1, NLRP3, and caspase-3 expression.	Quercetin	30-39	interleukin-1 receptor-associated kinase 1	Rattus norvegicus	175-180
34295174-7	2021	Results: Our data showed that quercetin attenuated the degeneration and erosion of articular cartilage, suppressed inflammation and apoptosis, and downregulated the levels of IRAK1, NLRP3, and caspase-3 expression.	Quercetin	30-39	NLR family, pyrin domain containing 3	Rattus norvegicus	182-187
34295174-7	2021	Results: Our data showed that quercetin attenuated the degeneration and erosion of articular cartilage, suppressed inflammation and apoptosis, and downregulated the levels of IRAK1, NLRP3, and caspase-3 expression.	Quercetin	30-39	caspase 3	Rattus norvegicus	193-202
34295174-8	2021	In vitro data showed that overexpression of NLRP3 could reverse the suppressive effect of quercetin on IL-1beta-induced rat chondrocyte injuries.	Quercetin	90-99	NLR family, pyrin domain containing 3	Rattus norvegicus	44-49
34295174-8	2021	In vitro data showed that overexpression of NLRP3 could reverse the suppressive effect of quercetin on IL-1beta-induced rat chondrocyte injuries.	Quercetin	90-99	interleukin 1 alpha	Rattus norvegicus	103-111
34356358-7	2021	Our findings indicated that the effects of quercetin on regulating the generation of mtROS were dependent on increased levels of deacetyl-SOD2 through the Nrf2-PGC-1alpha-Sirt1 signaling pathway.	Quercetin	43-52	superoxide dismutase 2	Homo sapiens	138-142
34356358-0	2021	Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1alpha-Sirt1 Pathway.	Quercetin	0-9	superoxide dismutase 2, mitochondrial	Mus musculus	185-189
34356358-7	2021	Our findings indicated that the effects of quercetin on regulating the generation of mtROS were dependent on increased levels of deacetyl-SOD2 through the Nrf2-PGC-1alpha-Sirt1 signaling pathway.	Quercetin	43-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
34356358-0	2021	Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1alpha-Sirt1 Pathway.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	198-202
34356358-0	2021	Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1alpha-Sirt1 Pathway.	Quercetin	0-9	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	203-213
34356358-7	2021	Our findings indicated that the effects of quercetin on regulating the generation of mtROS were dependent on increased levels of deacetyl-SOD2 through the Nrf2-PGC-1alpha-Sirt1 signaling pathway.	Quercetin	43-52	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	160-170
34356358-0	2021	Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1alpha-Sirt1 Pathway.	Quercetin	0-9	sirtuin 1	Mus musculus	214-219
34356358-5	2021	In the mouse model, NaIO3 treatment caused changes in the retinal structure and reduced pupil constriction, and quercetin treatment reversed the oxidative stress-related pathology by decreasing the level of superoxide dismutase 2 (SOD2) while enhancing the serum levels of catalase and glutathione.	Quercetin	112-121	superoxide dismutase 2, mitochondrial	Mus musculus	207-229
34335587-12	2021	In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI.	Quercetin	106-115	tumor protein p53	Homo sapiens	57-60
34335587-12	2021	In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI.	Quercetin	106-115	sirtuin 1	Homo sapiens	155-164
34356358-5	2021	In the mouse model, NaIO3 treatment caused changes in the retinal structure and reduced pupil constriction, and quercetin treatment reversed the oxidative stress-related pathology by decreasing the level of superoxide dismutase 2 (SOD2) while enhancing the serum levels of catalase and glutathione.	Quercetin	112-121	superoxide dismutase 2, mitochondrial	Mus musculus	231-235
34356358-5	2021	In the mouse model, NaIO3 treatment caused changes in the retinal structure and reduced pupil constriction, and quercetin treatment reversed the oxidative stress-related pathology by decreasing the level of superoxide dismutase 2 (SOD2) while enhancing the serum levels of catalase and glutathione.	Quercetin	112-121	catalase	Mus musculus	273-281
34335587-12	2021	In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI.	Quercetin	106-115	sirtuin 1	Homo sapiens	166-171
34356358-7	2021	Our findings indicated that the effects of quercetin on regulating the generation of mtROS were dependent on increased levels of deacetyl-SOD2 through the Nrf2-PGC-1alpha-Sirt1 signaling pathway.	Quercetin	43-52	sirtuin 1	Mus musculus	171-176
34097559-0	2021	Quercetin prevents isoprenaline-induced myocardial fibrosis by promoting autophagy via regulating miR-223-3p/FOXO3.	Quercetin	0-9	forkhead box O3	Rattus norvegicus	109-114
34335587-12	2021	In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI.	Quercetin	106-115	NOP2/Sun RNA methyltransferase 2	Homo sapiens	266-270
34180234-2	2021	In this study, quercetin, a natural neuroprotective flavonoid, was encapsulated in human serum albumin to obtain HSA@QC nanoparticles (HQ NPs) as a natural phyto-antioxidant albumin nanoagent for the treatment of advanced AD.	Quercetin	15-24	albumin	Rattus norvegicus	89-102
34263471-1	2021	In order to confirm the erectile potential of Quercetin (Q) in cyclosporine-induced hypertensive rats, this research assesses the influence of Q on the ectonucleotidases and adenosine deaminase (ADA) in the brains of rats.	Quercetin	143-144	adenosine deaminase	Rattus norvegicus	174-193
34263471-11	2021	The modulatory effects of Q on ectonucleotidases, along with its ability to minimize adenosine deaminase activity and increase nitric oxide levels, indicate that Q-rich plants and/or plant foods may be promising sources of dietary phytonutrients for erectile dysfunction management.	Quercetin	26-27	adenosine deaminase	Rattus norvegicus	85-104
34353059-16	2021	Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1beta, and other key targets to regulate inflammation, immunity, autophagy, and endocrine-related signaling pathways.	Quercetin	32-41	tumor necrosis factor	Homo sapiens	113-116
34353059-16	2021	Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1beta, and other key targets to regulate inflammation, immunity, autophagy, and endocrine-related signaling pathways.	Quercetin	32-41	prostaglandin-endoperoxide synthase 2	Homo sapiens	118-123
34353059-16	2021	Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1beta, and other key targets to regulate inflammation, immunity, autophagy, and endocrine-related signaling pathways.	Quercetin	32-41	matrix metallopeptidase 2	Homo sapiens	125-129
34353059-16	2021	Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1beta, and other key targets to regulate inflammation, immunity, autophagy, and endocrine-related signaling pathways.	Quercetin	32-41	interleukin 6	Homo sapiens	131-135
34353059-16	2021	Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1beta, and other key targets to regulate inflammation, immunity, autophagy, and endocrine-related signaling pathways.	Quercetin	32-41	interleukin 1 alpha	Homo sapiens	137-145
34376911-0	2021	Suppressive effects of quercetin on hydrogen peroxide-induced caveolin-1 phosphorylation in endothelial cells.	Quercetin	23-32	caveolin 1	Homo sapiens	62-72
34281178-1	2021	Quercetin-3-glucuronide (Q3GA), the main phase II metabolite of quercetin (Q) in human plasma, is considered to be a more stable form of Q for transport with the bloodstream to tissues, where it can be potentially deconjugated by beta-glucuronidase (beta-Gluc) to Q aglycone, which easily enters the brain.	Quercetin	64-73	glucuronidase beta	Homo sapiens	230-248
34281178-1	2021	Quercetin-3-glucuronide (Q3GA), the main phase II metabolite of quercetin (Q) in human plasma, is considered to be a more stable form of Q for transport with the bloodstream to tissues, where it can be potentially deconjugated by beta-glucuronidase (beta-Gluc) to Q aglycone, which easily enters the brain.	Quercetin	75-76	glucuronidase beta	Homo sapiens	230-248
34281178-1	2021	Quercetin-3-glucuronide (Q3GA), the main phase II metabolite of quercetin (Q) in human plasma, is considered to be a more stable form of Q for transport with the bloodstream to tissues, where it can be potentially deconjugated by beta-glucuronidase (beta-Gluc) to Q aglycone, which easily enters the brain.	Quercetin	137-138	glucuronidase beta	Homo sapiens	230-248
34376911-3	2021	Although quercetin is known to be an anti-atherosclerosis factor that acts as a dietary antioxidant, little is known about its role in the regulation of caveolin-1 phosphorylation.	Quercetin	9-18	caveolin 1	Homo sapiens	153-163
34376911-4	2021	In this study, we investigated the inhibitory effect of quercetin on hydrogen peroxide-induced caveolin-1 phosphorylation in human umbilical vein endothelial cells.	Quercetin	56-65	caveolin 1	Homo sapiens	95-105
34376911-5	2021	Quercetin inhibited caveolin-1 phosphorylation in cells pretreated with quercetin for 24 h and then exposed to hydrogen peroxide.	Quercetin	0-9	caveolin 1	Homo sapiens	20-30
34376911-5	2021	Quercetin inhibited caveolin-1 phosphorylation in cells pretreated with quercetin for 24 h and then exposed to hydrogen peroxide.	Quercetin	72-81	caveolin 1	Homo sapiens	20-30
34376911-8	2021	By contrast, pretreatment with quercetin suppressed the increase in vascular permeability and decreased VE-cadherin expression.	Quercetin	31-40	cadherin 5	Homo sapiens	104-115
34376911-9	2021	These results indicate that deconjugated quercetin can play a role in the prevention of altered vascular permeability under oxidative stress by suppressing caveolin-1 phosphorylation.	Quercetin	41-50	caveolin 1	Homo sapiens	156-166
33318415-5	2021	Quercetin markedly increased the thickness of the retinal cell layer, increased the number of ganglion cells, and decreased the overexpression of the pro-inflammatory factors interleukin-1beta, interleukin-18, interleukin-6 and tumor necrosis factor-alpha in the retinal tissue as well as the overexpression of high mobility group box-1 and the overactivation of the NLRP3 inflammasome.	Quercetin	0-9	interleukin 18	Rattus norvegicus	194-208
33318415-5	2021	Quercetin markedly increased the thickness of the retinal cell layer, increased the number of ganglion cells, and decreased the overexpression of the pro-inflammatory factors interleukin-1beta, interleukin-18, interleukin-6 and tumor necrosis factor-alpha in the retinal tissue as well as the overexpression of high mobility group box-1 and the overactivation of the NLRP3 inflammasome.	Quercetin	0-9	interleukin 6	Rattus norvegicus	210-223
33318415-0	2021	Quercetin protects against diabetic retinopathy in rats by inducing heme oxygenase-1 expression.	Quercetin	0-9	heme oxygenase 1	Rattus norvegicus	68-84
33318415-5	2021	Quercetin markedly increased the thickness of the retinal cell layer, increased the number of ganglion cells, and decreased the overexpression of the pro-inflammatory factors interleukin-1beta, interleukin-18, interleukin-6 and tumor necrosis factor-alpha in the retinal tissue as well as the overexpression of high mobility group box-1 and the overactivation of the NLRP3 inflammasome.	Quercetin	0-9	tumor necrosis factor	Rattus norvegicus	228-255
33318415-5	2021	Quercetin markedly increased the thickness of the retinal cell layer, increased the number of ganglion cells, and decreased the overexpression of the pro-inflammatory factors interleukin-1beta, interleukin-18, interleukin-6 and tumor necrosis factor-alpha in the retinal tissue as well as the overexpression of high mobility group box-1 and the overactivation of the NLRP3 inflammasome.	Quercetin	0-9	interleukin 1 beta	Rattus norvegicus	175-192
33318415-5	2021	Quercetin markedly increased the thickness of the retinal cell layer, increased the number of ganglion cells, and decreased the overexpression of the pro-inflammatory factors interleukin-1beta, interleukin-18, interleukin-6 and tumor necrosis factor-alpha in the retinal tissue as well as the overexpression of high mobility group box-1 and the overactivation of the NLRP3 inflammasome.	Quercetin	0-9	high mobility group box 1	Rattus norvegicus	311-336
33318415-5	2021	Quercetin markedly increased the thickness of the retinal cell layer, increased the number of ganglion cells, and decreased the overexpression of the pro-inflammatory factors interleukin-1beta, interleukin-18, interleukin-6 and tumor necrosis factor-alpha in the retinal tissue as well as the overexpression of high mobility group box-1 and the overactivation of the NLRP3 inflammasome.	Quercetin	0-9	NLR family, pyrin domain containing 3	Rattus norvegicus	367-372
33318415-6	2021	Furthermore, quercetin inhibited the overexpression of TLR4 and NF-kappaBp65, reduced the expression of the pro-angiogenic vascular endothelial growth factor and soluble intercellular adhesion molecule-1, and upregulated the neurotrophins brain-derived neurotrophic factor and nerve growth factor.	Quercetin	13-22	toll-like receptor 4	Rattus norvegicus	55-59
33318415-6	2021	Furthermore, quercetin inhibited the overexpression of TLR4 and NF-kappaBp65, reduced the expression of the pro-angiogenic vascular endothelial growth factor and soluble intercellular adhesion molecule-1, and upregulated the neurotrophins brain-derived neurotrophic factor and nerve growth factor.	Quercetin	13-22	intercellular adhesion molecule 1	Rattus norvegicus	170-203
33318415-6	2021	Furthermore, quercetin inhibited the overexpression of TLR4 and NF-kappaBp65, reduced the expression of the pro-angiogenic vascular endothelial growth factor and soluble intercellular adhesion molecule-1, and upregulated the neurotrophins brain-derived neurotrophic factor and nerve growth factor.	Quercetin	13-22	brain-derived neurotrophic factor	Rattus norvegicus	239-272
33318415-6	2021	Furthermore, quercetin inhibited the overexpression of TLR4 and NF-kappaBp65, reduced the expression of the pro-angiogenic vascular endothelial growth factor and soluble intercellular adhesion molecule-1, and upregulated the neurotrophins brain-derived neurotrophic factor and nerve growth factor.	Quercetin	13-22	nerve growth factor	Rattus norvegicus	277-296
33318415-7	2021	Intraperitoneal injection of the heme oxygenase-1 inhibitor zinc protoporphyrin blocked the protective effect of quercetin.	Quercetin	113-122	heme oxygenase 1	Rattus norvegicus	33-49
33318415-8	2021	These findings suggest that quercetin exerts therapeutic effects in diabetic retinopathy possibly by inducing heme oxygenase-1 expression.	Quercetin	28-37	heme oxygenase 1	Rattus norvegicus	110-126
34401548-13	2021	Quercetin (85 mg/kgbw) and EEVA (400 mg/kgbw) reduce AST, ALT, Ureum, Creatinine, CK- MB, LDH, Troponin T, BNP significantly and increase rats" SOD level compared with negative control.	Quercetin	0-9	natriuretic peptide B	Rattus norvegicus	107-110
34183756-7	2022	Further investigation revealed licochalcone A, licochalcone B, licochalcone C and echinatin in Radix Glycyrrhizae, as well as quercetin and kaempferol in Folium Llicis Purpureae, to be time-dependent CYP3A inhibitors.	Quercetin	126-135	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	200-205
34208928-0	2021	Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of Mpro and Its Antiviral Activity in Cells against SARS-CoV-2.	Quercetin	28-37	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	78-82
34208928-3	2021	The natural flavonoid quercetin 1 has been recently reported to be a potent Mpro inhibitor in vitro, and we explored the effect produced by the introduction of organoselenium functionalities in this scaffold.	Quercetin	22-31	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	76-80
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	Quercetin	34-43	tumor protein p53	Homo sapiens	131-135
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	Quercetin	34-43	AKT serine/threonine kinase 1	Homo sapiens	137-141
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	Quercetin	34-43	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	147-150
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	Quercetin	34-43	AKT serine/threonine kinase 1	Homo sapiens	160-163
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	Quercetin	34-43	tumor protein p53	Homo sapiens	165-168
34257824-6	2021	For example, quercetin arrests human cervical cancer cell growth by blocking the G2/M phase cell cycle and inducing mitochondrial apoptosis through a p53-dependent mechanism.	Quercetin	13-22	tumor protein p53	Homo sapiens	150-153
34335941-5	2021	Also significant effects of quercetin on Bax, Bcl-2 and caspase-3 were observed, that can prove its ability to induce apoptosis.	Quercetin	28-37	BCL2 associated X, apoptosis regulator	Homo sapiens	41-44
34335941-5	2021	Also significant effects of quercetin on Bax, Bcl-2 and caspase-3 were observed, that can prove its ability to induce apoptosis.	Quercetin	28-37	BCL2 apoptosis regulator	Homo sapiens	46-51
34335941-5	2021	Also significant effects of quercetin on Bax, Bcl-2 and caspase-3 were observed, that can prove its ability to induce apoptosis.	Quercetin	28-37	caspase 3	Homo sapiens	56-65
34335941-8	2021	The obtained results from all these performed analysis proved that quercetin can induce apoptosis in human lung cancer cells, additionally quercetin showed ability to reduce MDA and increase SOD and GSHP levels which indicates its ability in suppressing oxidative stress, Quercetin has played a therapeutic role in cyclophosphamide induced lung toxicity as it has improved restoring of the damaged lung tissue as discussed in this research work.	Quercetin	139-148	superoxide dismutase 1	Homo sapiens	191-194
34201978-11	2021	Moreover, the addition of Q in the PLA/GO matrix stimulated the production of IL-6 at 24 h, which could be linked to an acute inflammatory response in the exposed fibroblast cells, as a potential effect of wound healing.	Quercetin	26-27	interleukin 6	Mus musculus	78-82
34202188-7	2021	Supplementation of quercetin counteracted the growth-inhibiting action of CdCl2 by recovering ERK protein phosphorylation levels, attenuating ROS overproduction, decreasing MDA content and reducing the expression of GRP78 in cells exposed to CdCl2.	Quercetin	19-28	mitogen-activated protein kinase 1	Homo sapiens	94-97
34202188-7	2021	Supplementation of quercetin counteracted the growth-inhibiting action of CdCl2 by recovering ERK protein phosphorylation levels, attenuating ROS overproduction, decreasing MDA content and reducing the expression of GRP78 in cells exposed to CdCl2.	Quercetin	19-28	heat shock protein family A (Hsp70) member 5	Homo sapiens	216-221
34107032-0	2021	RNA pull-down confocal nanoscanning (RP-CONA) detects quercetin as pri-miR-7/HuR interaction inhibitor that decreases alpha-synuclein levels.	Quercetin	54-63	ELAV like RNA binding protein 1	Homo sapiens	77-80
34214302-0	2021	Quercetin promotes behavioral recovery and biomolecular changes of melanocortin-4 receptor in mice with ischemic stroke.	Quercetin	0-9	melanocortin 4 receptor	Mus musculus	67-90
34214302-4	2021	This study was aimed to investigate quercetin administration on the behavioral functions (motor and sensory) and expression of melanocortin-4 receptor (MC4R) in mice with ischemic stroke.	Quercetin	36-45	melanocortin 4 receptor	Mus musculus	127-150
34214302-4	2021	This study was aimed to investigate quercetin administration on the behavioral functions (motor and sensory) and expression of melanocortin-4 receptor (MC4R) in mice with ischemic stroke.	Quercetin	36-45	melanocortin 4 receptor	Mus musculus	152-156
34214302-10	2021	Quercetin improved motor and sensory function, and upregulated expression of MC4R.	Quercetin	0-9	melanocortin 4 receptor	Mus musculus	77-81
34214302-11	2021	CONCLUSIONS: Quercetin administration after ischemic stroke improves behavioral function, possibly through the upregulation of MC4R in the brain.	Quercetin	13-22	melanocortin 4 receptor	Mus musculus	127-131
34214346-0	2021	The effects of quercetin on the expression of SREBP-1c mRNA in high-fat diet-induced NAFLD in mice.	Quercetin	15-24	sterol regulatory element binding transcription factor 1	Mus musculus	46-54
34214346-5	2021	RESULTS: HFD significantly increased the expression of SREBP-1c mRNA; meanwhile, quercetin and repaired feed significantly reduced the expression of SREBP-1c mRNA in the liver.	Quercetin	81-90	sterol regulatory element binding transcription factor 1	Mus musculus	55-63
34214346-5	2021	RESULTS: HFD significantly increased the expression of SREBP-1c mRNA; meanwhile, quercetin and repaired feed significantly reduced the expression of SREBP-1c mRNA in the liver.	Quercetin	81-90	sterol regulatory element binding transcription factor 1	Mus musculus	149-157
34214346-7	2021	CONCLUSIONS: The present study suggests that quercetin has an inhibitory effect on SREBP-1c expression and improved liver pathology in NAFLD mice.	Quercetin	45-54	sterol regulatory element binding transcription factor 1	Mus musculus	83-91
34214359-3	2021	Quercetin, known as an antioxidant, binds free radicals and modulates endogenous antioxidants through Nrf2 activations is expected as a potential agent to reduce the risk of nicotine dependence.	Quercetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-106
34107032-0	2021	RNA pull-down confocal nanoscanning (RP-CONA) detects quercetin as pri-miR-7/HuR interaction inhibitor that decreases alpha-synuclein levels.	Quercetin	54-63	synuclein alpha	Homo sapiens	118-133
34205604-6	2021	The immunofluorescence study revealed that R and Q increased the LDLR expression, while only Q improved LDL-C uptake in HepG2 cells.	Quercetin	49-50	low density lipoprotein receptor	Homo sapiens	65-69
34107032-6	2021	Our method identified a natural product quercetin as a molecule able to upregulate cellular miR-7 levels and downregulate the expression of alpha-synuclein.	Quercetin	40-49	leukocyte immunoglobulin like receptor B1	Homo sapiens	92-97
34205659-6	2021	Studies in enteroendocrine cell models have shown that dietary peptides, amino acids, and phytochemicals, such as quercetin, can directly stimulate GLP-1 secretion.	Quercetin	114-123	glucagon	Homo sapiens	148-153
34107032-6	2021	Our method identified a natural product quercetin as a molecule able to upregulate cellular miR-7 levels and downregulate the expression of alpha-synuclein.	Quercetin	40-49	synuclein alpha	Homo sapiens	140-155
34447501-0	2021	Quercetin Can Inhibit Angiogenesis via the Down Regulation of MALAT1 and MIAT LncRNAs in Human Umbilical Vein Endothelial Cells.	Quercetin	0-9	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	62-68
34195429-6	2021	Results of a palmitate-bovine serum albumin fatty acid oxidation assay showed that quercetin significantly increased the oxygen consumption of AML12 hepatocytes, suggesting enhanced fatty acid beta-oxidation.	Quercetin	83-92	albumin	Mus musculus	30-43
34447501-0	2021	Quercetin Can Inhibit Angiogenesis via the Down Regulation of MALAT1 and MIAT LncRNAs in Human Umbilical Vein Endothelial Cells.	Quercetin	0-9	myocardial infarction associated transcript	Homo sapiens	73-77
34447501-6	2021	In this study, we assessed the anti-angiogenic activity of quercetin on human umbilical vein endothelial cells (HUVEC) via the expression of MALAT1 and MIAT genes.	Quercetin	59-68	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	141-147
34447501-6	2021	In this study, we assessed the anti-angiogenic activity of quercetin on human umbilical vein endothelial cells (HUVEC) via the expression of MALAT1 and MIAT genes.	Quercetin	59-68	myocardial infarction associated transcript	Homo sapiens	152-156
34447501-12	2021	The MALAT1/GAPDH ratio was computed as 0.21 for 24h, 0.18 for 48h, and 0.29 for 72 h. The MIAT/GAPDH ratio was computed as 0.82 for 24h, 0.84 for 48h, and 0.78 for 72 h. Conclusions: In conclusion, quercetin treatment had an anti-angiogenic effect on HUVEC cells, at least partially via the down regulation of MALAT1 and MIAT LncRNAs gene expression.	Quercetin	198-207	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	4-10
34447501-12	2021	The MALAT1/GAPDH ratio was computed as 0.21 for 24h, 0.18 for 48h, and 0.29 for 72 h. The MIAT/GAPDH ratio was computed as 0.82 for 24h, 0.84 for 48h, and 0.78 for 72 h. Conclusions: In conclusion, quercetin treatment had an anti-angiogenic effect on HUVEC cells, at least partially via the down regulation of MALAT1 and MIAT LncRNAs gene expression.	Quercetin	198-207	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	11-16
34447501-12	2021	The MALAT1/GAPDH ratio was computed as 0.21 for 24h, 0.18 for 48h, and 0.29 for 72 h. The MIAT/GAPDH ratio was computed as 0.82 for 24h, 0.84 for 48h, and 0.78 for 72 h. Conclusions: In conclusion, quercetin treatment had an anti-angiogenic effect on HUVEC cells, at least partially via the down regulation of MALAT1 and MIAT LncRNAs gene expression.	Quercetin	198-207	myocardial infarction associated transcript	Homo sapiens	90-94
34447501-12	2021	The MALAT1/GAPDH ratio was computed as 0.21 for 24h, 0.18 for 48h, and 0.29 for 72 h. The MIAT/GAPDH ratio was computed as 0.82 for 24h, 0.84 for 48h, and 0.78 for 72 h. Conclusions: In conclusion, quercetin treatment had an anti-angiogenic effect on HUVEC cells, at least partially via the down regulation of MALAT1 and MIAT LncRNAs gene expression.	Quercetin	198-207	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	95-100
34447501-12	2021	The MALAT1/GAPDH ratio was computed as 0.21 for 24h, 0.18 for 48h, and 0.29 for 72 h. The MIAT/GAPDH ratio was computed as 0.82 for 24h, 0.84 for 48h, and 0.78 for 72 h. Conclusions: In conclusion, quercetin treatment had an anti-angiogenic effect on HUVEC cells, at least partially via the down regulation of MALAT1 and MIAT LncRNAs gene expression.	Quercetin	198-207	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	310-316
34447501-12	2021	The MALAT1/GAPDH ratio was computed as 0.21 for 24h, 0.18 for 48h, and 0.29 for 72 h. The MIAT/GAPDH ratio was computed as 0.82 for 24h, 0.84 for 48h, and 0.78 for 72 h. Conclusions: In conclusion, quercetin treatment had an anti-angiogenic effect on HUVEC cells, at least partially via the down regulation of MALAT1 and MIAT LncRNAs gene expression.	Quercetin	198-207	myocardial infarction associated transcript	Homo sapiens	321-325
34497749-13	2021	Quercetin and Luteolin were verified to have good binding capability with the hub potential targets IL6, MAPK1, AKT1 through molecular docking.	Quercetin	0-9	interleukin 6	Homo sapiens	100-103
34497749-13	2021	Quercetin and Luteolin were verified to have good binding capability with the hub potential targets IL6, MAPK1, AKT1 through molecular docking.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	105-110
34497749-13	2021	Quercetin and Luteolin were verified to have good binding capability with the hub potential targets IL6, MAPK1, AKT1 through molecular docking.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	112-116
34194527-11	2021	Several key ingredients (quercetin, kaempferol, and stigmasterol) and primary core target genes (PTGS1, NCOA2, and PRSS1) were detected through ingredient-target gene network analysis.	Quercetin	25-34	prostaglandin-endoperoxide synthase 1	Homo sapiens	97-102
34208730-0	2021	Quercetin Induces Anticancer Activity by Upregulating Pro-NAG-1/GDF15 in Differentiated Thyroid Cancer Cells.	Quercetin	0-9	growth differentiation factor 15	Homo sapiens	58-63
34208730-0	2021	Quercetin Induces Anticancer Activity by Upregulating Pro-NAG-1/GDF15 in Differentiated Thyroid Cancer Cells.	Quercetin	0-9	growth differentiation factor 15	Homo sapiens	64-69
34208730-7	2021	In particular, quercetin highly induced the expression of pro-NAG-1 but not that of mature NAG-1, with enhanced anticancer activity, including apoptosis induction and cell cycle arrest.	Quercetin	15-24	growth differentiation factor 15	Homo sapiens	62-67
34208730-8	2021	Examination of the NAG-1 promoter activity showed that p53, C/EBPalpha, or C/EBPdelta played a role in quercetin-induced NAG-1 expression.	Quercetin	103-112	tumor protein p53	Homo sapiens	55-58
34208730-8	2021	Examination of the NAG-1 promoter activity showed that p53, C/EBPalpha, or C/EBPdelta played a role in quercetin-induced NAG-1 expression.	Quercetin	103-112	CCAAT enhancer binding protein alpha	Homo sapiens	60-70
34208730-8	2021	Examination of the NAG-1 promoter activity showed that p53, C/EBPalpha, or C/EBPdelta played a role in quercetin-induced NAG-1 expression.	Quercetin	103-112	CCAAT enhancer binding protein delta	Homo sapiens	75-85
34208730-8	2021	Examination of the NAG-1 promoter activity showed that p53, C/EBPalpha, or C/EBPdelta played a role in quercetin-induced NAG-1 expression.	Quercetin	103-112	growth differentiation factor 15	Homo sapiens	121-126
34102611-7	2021	Interestingly, depletion of ASAH1 in pre-senescent cells sensitized these cells to the senolytics Dasatinib and Quercetin (D+Q).	Quercetin	112-121	N-acylsphingosine amidohydrolase 1	Homo sapiens	28-33
34102994-2	2022	Recently, multiple anticancer effects of quercetin have been described, including inhibitory activity against uPA.	Quercetin	41-50	plasminogen activator, urokinase	Homo sapiens	110-113
34102994-4	2022	OBJECTIVE: The objectives of the study were to assess the antimetastatic potential of quercetin analogues by analyzing their binding affinity for uPA and to select the compounds with improved pharmacological profiles.	Quercetin	86-95	plasminogen activator, urokinase	Homo sapiens	146-149
34102994-5	2022	METHODS: Binding affinities of structural analogues of quercetin to uPA receptor were determined by molecular docking analysis using Molegro Virtual Docker software, and molecular descriptors relevant for estimating pharmacological profile were calculated from ligand structures using computational models.	Quercetin	55-64	plasminogen activator, urokinase	Homo sapiens	68-71
34102994-6	2022	RESULTS: Among 44 quercetin analogues, only one quercetin analogue (3,6,2",4",5"-pentahydroxyflavone) was found to possess both higher aqueous solubility and membrane permeability, and a stronger affinity for uPA than quercetin, which makes it the potential lead compound for anticancer drug development.	Quercetin	18-27	plasminogen activator, urokinase	Homo sapiens	209-212
34102994-6	2022	RESULTS: Among 44 quercetin analogues, only one quercetin analogue (3,6,2",4",5"-pentahydroxyflavone) was found to possess both higher aqueous solubility and membrane permeability, and a stronger affinity for uPA than quercetin, which makes it the potential lead compound for anticancer drug development.	Quercetin	48-57	plasminogen activator, urokinase	Homo sapiens	209-212
34102994-6	2022	RESULTS: Among 44 quercetin analogues, only one quercetin analogue (3,6,2",4",5"-pentahydroxyflavone) was found to possess both higher aqueous solubility and membrane permeability, and a stronger affinity for uPA than quercetin, which makes it the potential lead compound for anticancer drug development.	Quercetin	218-227	plasminogen activator, urokinase	Homo sapiens	209-212
34149863-13	2021	SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways.	Quercetin	39-48	prostaglandin-endoperoxide synthase 2	Homo sapiens	166-171
34194527-11	2021	Several key ingredients (quercetin, kaempferol, and stigmasterol) and primary core target genes (PTGS1, NCOA2, and PRSS1) were detected through ingredient-target gene network analysis.	Quercetin	25-34	nuclear receptor coactivator 2	Homo sapiens	104-109
34204866-0	2021	Protective Effects of Quercetin on Oxidative Stress-Induced Tubular Epithelial Damage in the Experimental Rat Hyperoxaluria Model.	Quercetin	22-31	sequestosome 1	Rattus norvegicus	35-59
34204866-9	2021	Histopathological assessments and immunohistochemical analyses for oxidative stress and inflammation indicators p38 mitogen-activated protein kinase (p38-MAPK) and nuclear factor kappa B (NF-kB) were performed on renal tissues.&nbsp;Results: The MDA levels were significantly lower in the quercetin-treated group than in the EG-treated group (p = 0.001).	Quercetin	289-298	mitogen activated protein kinase 14	Rattus norvegicus	112-148
34204866-9	2021	Histopathological assessments and immunohistochemical analyses for oxidative stress and inflammation indicators p38 mitogen-activated protein kinase (p38-MAPK) and nuclear factor kappa B (NF-kB) were performed on renal tissues.&nbsp;Results: The MDA levels were significantly lower in the quercetin-treated group than in the EG-treated group (p = 0.001).	Quercetin	289-298	mitogen activated protein kinase 14	Rattus norvegicus	150-158
34204866-9	2021	Histopathological assessments and immunohistochemical analyses for oxidative stress and inflammation indicators p38 mitogen-activated protein kinase (p38-MAPK) and nuclear factor kappa B (NF-kB) were performed on renal tissues.&nbsp;Results: The MDA levels were significantly lower in the quercetin-treated group than in the EG-treated group (p = 0.001).	Quercetin	289-298	nuclear factor kappa B subunit 1	Rattus norvegicus	164-186
34204866-9	2021	Histopathological assessments and immunohistochemical analyses for oxidative stress and inflammation indicators p38 mitogen-activated protein kinase (p38-MAPK) and nuclear factor kappa B (NF-kB) were performed on renal tissues.&nbsp;Results: The MDA levels were significantly lower in the quercetin-treated group than in the EG-treated group (p = 0.001).	Quercetin	289-298	nuclear factor kappa B subunit 1	Rattus norvegicus	188-193
34204866-10	2021	Although CAT levels were higher in the quercetin-treated group than the EG-administered group, they were not significantly different between these groups.	Quercetin	39-48	catalase	Rattus norvegicus	9-12
34296561-11	2021	The results of molecular docking showed that quercetin and PTGS2 can bind stably and interact through amino acid residues THR206, TRP387, ASN382, etc.	Quercetin	45-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	59-64
34311541-6	2021	The most appreciated route of quercetin effect on prostate cancer cells is the detachment of Bax from Bcl-xL and the stimulation of caspase families.	Quercetin	30-39	BCL2 associated X, apoptosis regulator	Homo sapiens	93-96
34311541-6	2021	The most appreciated route of quercetin effect on prostate cancer cells is the detachment of Bax from Bcl-xL and the stimulation of caspase families.	Quercetin	30-39	BCL2 like 1	Homo sapiens	102-108
34311541-8	2021	For instance, a combination of TNF-related apoptosis-inducing ligand (TRAIL) and quercetin has been recommended as a novel modality for the treatment of prostate cancer.	Quercetin	81-90	TNF superfamily member 10	Homo sapiens	31-68
34016844-0	2021	Quercetin, Perillyl alcohol and Berberine ameliorate right ventricular disorders in experimental pulmonary arterial hypertension: Effects on miR-204, miR-27a, fibrotic, apoptotic and inflammatory factors.	Quercetin	0-9	microRNA 204	Rattus norvegicus	141-148
34254227-0	2021	The effects of the esterified Quercetin with omega3 and omega6 fatty acids on viability, nanomechanical properties, and BAX/BCL-2 gene expression in MCF-7 cells.	Quercetin	30-39	BCL2 associated X, apoptosis regulator	Homo sapiens	120-123
34254227-0	2021	The effects of the esterified Quercetin with omega3 and omega6 fatty acids on viability, nanomechanical properties, and BAX/BCL-2 gene expression in MCF-7 cells.	Quercetin	30-39	BCL2 apoptosis regulator	Homo sapiens	124-129
34254227-1	2021	Quercetin is one of the major flavonoids and it appears to have cytotoxic effects on various cancer cells through regulating the apoptosis pathway genes such as BAX and BCL2.	Quercetin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	161-164
34254227-1	2021	Quercetin is one of the major flavonoids and it appears to have cytotoxic effects on various cancer cells through regulating the apoptosis pathway genes such as BAX and BCL2.	Quercetin	0-9	BCL2 apoptosis regulator	Homo sapiens	169-173
34123826-10	2021	The results of molecular docking showed that Quercetin was most likely to be developed as drugs that interacted directly with CXCL1-2.	Quercetin	45-54	C-X-C motif chemokine ligand 12	Homo sapiens	126-133
34150114-7	2021	The Bax and Bcl-2 levels in the quercetin intervention group showed a tendency to increase progressively in comparison with the blank control group, and Cyclin D1 showed a tendency to decrease progressively (P<0.05).	Quercetin	32-41	BCL2 associated X, apoptosis regulator	Homo sapiens	4-7
34065697-0	2021	Quercetin and Isorhamnetin Attenuate Benzo(a)pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways.	Quercetin	0-9	aryl hydrocarbon receptor	Homo sapiens	118-121
34065697-0	2021	Quercetin and Isorhamnetin Attenuate Benzo(a)pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	126-130
34065697-9	2021	Furthermore, quercetin and isorhamnetin induced the translocation of aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (NRF2), which regulate the expression level of phase enzymes.	Quercetin	13-22	aryl hydrocarbon receptor	Homo sapiens	69-94
34065697-9	2021	Furthermore, quercetin and isorhamnetin induced the translocation of aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (NRF2), which regulate the expression level of phase enzymes.	Quercetin	13-22	aryl hydrocarbon receptor	Homo sapiens	96-99
34065697-9	2021	Furthermore, quercetin and isorhamnetin induced the translocation of aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (NRF2), which regulate the expression level of phase enzymes.	Quercetin	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	105-148
34065697-9	2021	Furthermore, quercetin and isorhamnetin induced the translocation of aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (NRF2), which regulate the expression level of phase enzymes.	Quercetin	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
34093537-8	2021	Furthermore, elevated SIRT1 and decreased acetylated NFkappaB p65 expression were responsible for the mechanism of quercetin, and the beneficial effects of quercetin were reversed by the SIRT1 antagonist EX527 and mimicked by the SIRT agonist SRT1720.	Quercetin	115-124	sirtuin 1	Mus musculus	22-27
34093537-8	2021	Furthermore, elevated SIRT1 and decreased acetylated NFkappaB p65 expression were responsible for the mechanism of quercetin, and the beneficial effects of quercetin were reversed by the SIRT1 antagonist EX527 and mimicked by the SIRT agonist SRT1720.	Quercetin	115-124	sirtuin 1	Mus musculus	187-192
34093537-8	2021	Furthermore, elevated SIRT1 and decreased acetylated NFkappaB p65 expression were responsible for the mechanism of quercetin, and the beneficial effects of quercetin were reversed by the SIRT1 antagonist EX527 and mimicked by the SIRT agonist SRT1720.	Quercetin	156-165	sirtuin 1	Mus musculus	22-27
34093537-8	2021	Furthermore, elevated SIRT1 and decreased acetylated NFkappaB p65 expression were responsible for the mechanism of quercetin, and the beneficial effects of quercetin were reversed by the SIRT1 antagonist EX527 and mimicked by the SIRT agonist SRT1720.	Quercetin	156-165	sirtuin 1	Mus musculus	187-192
34093537-9	2021	The findings in this study suggest that targeting monocyte/macrophage and mast cell activities may represent an attractive approach for therapeutic intervention of HO and that quercetin may serve as a promising therapeutic candidate for the treatment of trauma-induced HO by modulating SIRT1/NFkappaB signaling.	Quercetin	176-185	sirtuin 1	Mus musculus	286-291
34150114-8	2021	The of Caspase-3, GRP78, and CHOP expression levels in the quercetin intervention group rose significantly in comparison with the blank control group (P<0.05).	Quercetin	59-68	caspase 3	Homo sapiens	7-16
34150114-7	2021	The Bax and Bcl-2 levels in the quercetin intervention group showed a tendency to increase progressively in comparison with the blank control group, and Cyclin D1 showed a tendency to decrease progressively (P<0.05).	Quercetin	32-41	BCL2 apoptosis regulator	Homo sapiens	12-17
34150114-8	2021	The of Caspase-3, GRP78, and CHOP expression levels in the quercetin intervention group rose significantly in comparison with the blank control group (P<0.05).	Quercetin	59-68	heat shock protein family A (Hsp70) member 5	Homo sapiens	18-23
34150114-8	2021	The of Caspase-3, GRP78, and CHOP expression levels in the quercetin intervention group rose significantly in comparison with the blank control group (P<0.05).	Quercetin	59-68	DNA damage inducible transcript 3	Homo sapiens	29-33
34150114-9	2021	The IRE1, p-Perk, and c-ATF6 levels in the quercetin intervention group showed a tendency to rise gradually in comparison with the blank control group (P<0.05).	Quercetin	43-52	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	4-8
34150114-9	2021	The IRE1, p-Perk, and c-ATF6 levels in the quercetin intervention group showed a tendency to rise gradually in comparison with the blank control group (P<0.05).	Quercetin	43-52	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	12-16
34064664-9	2021	Quercetin, on the other hand, had significantly downregulated the phosphorylated proteins of ERK1/2, p38, and JNK1/2.	Quercetin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	93-99
34064664-7	2021	Exposure to Ang II increased cell surface area, intracellular superoxide anion level, NADPH oxidase and inducible nitric oxide synthase activities, and reduced cellular superoxide dismutase activity and nitrite level, which were similarly reversed by both rutin and quercetin.	Quercetin	266-275	angiotensinogen	Rattus norvegicus	12-18
34064664-9	2021	Quercetin, on the other hand, had significantly downregulated the phosphorylated proteins of ERK1/2, p38, and JNK1/2.	Quercetin	0-9	mitogen activated protein kinase 14	Rattus norvegicus	101-104
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	158-167	interleukin 1 alpha	Rattus norvegicus	44-52
34249264-0	2021	Quercetin protects islet beta-cells from oxidation-induced apoptosis via Sirt3 in T2DM.	Quercetin	0-9	sirtuin 3	Rattus norvegicus	73-78
34249264-8	2021	Results: When INS1 cells and diabetic mice were treated with quercetin, the levels of SOD2, CAT, and Sirt3 proteins were increased, the levels of cleaved Caspase-3 and the ratio of Bax to BCL-2 were decreased at different degrees, along with reduced blood glucose levels and elevated insulin levels in diabetic mice.	Quercetin	61-70	superoxide dismutase 2, mitochondrial	Mus musculus	86-90
34249264-8	2021	Results: When INS1 cells and diabetic mice were treated with quercetin, the levels of SOD2, CAT, and Sirt3 proteins were increased, the levels of cleaved Caspase-3 and the ratio of Bax to BCL-2 were decreased at different degrees, along with reduced blood glucose levels and elevated insulin levels in diabetic mice.	Quercetin	61-70	catalase	Mus musculus	92-95
34249264-8	2021	Results: When INS1 cells and diabetic mice were treated with quercetin, the levels of SOD2, CAT, and Sirt3 proteins were increased, the levels of cleaved Caspase-3 and the ratio of Bax to BCL-2 were decreased at different degrees, along with reduced blood glucose levels and elevated insulin levels in diabetic mice.	Quercetin	61-70	sirtuin 3	Mus musculus	101-106
34249264-8	2021	Results: When INS1 cells and diabetic mice were treated with quercetin, the levels of SOD2, CAT, and Sirt3 proteins were increased, the levels of cleaved Caspase-3 and the ratio of Bax to BCL-2 were decreased at different degrees, along with reduced blood glucose levels and elevated insulin levels in diabetic mice.	Quercetin	61-70	caspase 3	Mus musculus	154-163
34249264-8	2021	Results: When INS1 cells and diabetic mice were treated with quercetin, the levels of SOD2, CAT, and Sirt3 proteins were increased, the levels of cleaved Caspase-3 and the ratio of Bax to BCL-2 were decreased at different degrees, along with reduced blood glucose levels and elevated insulin levels in diabetic mice.	Quercetin	61-70	BCL2-associated X protein	Mus musculus	181-184
34249264-8	2021	Results: When INS1 cells and diabetic mice were treated with quercetin, the levels of SOD2, CAT, and Sirt3 proteins were increased, the levels of cleaved Caspase-3 and the ratio of Bax to BCL-2 were decreased at different degrees, along with reduced blood glucose levels and elevated insulin levels in diabetic mice.	Quercetin	61-70	B cell leukemia/lymphoma 2	Mus musculus	188-193
34249264-10	2021	Conclusion: Quercetin protected islet beta-cells from oxidation-induced apoptosis via Sirt3 in T2DM, which would be beneficial to develop new strategies for preventing beta-cell failure in T2DM.	Quercetin	12-21	sirtuin 3	Rattus norvegicus	86-91
34277870-9	2021	Quercetin nanoparticles upregulates Su(Fu) mRNA expressions and downregulates gli mRNA expressions in the LNCaP cells.	Quercetin	0-9	GLI family zinc finger 1	Homo sapiens	78-81
34136194-3	2021	Results showed that Quercetin at 25 mg/kg and 50 mg/kg could significantly (p < .05) increase the intestinal transit rate, motilin, gastrin, substance P levels, and concentration of short-chain fatty acids (SCFAs), reduce the somatostatin levels, and improve the gastrointestinal peristalsis of rats.	Quercetin	20-29	motilin	Rattus norvegicus	123-130
34136194-3	2021	Results showed that Quercetin at 25 mg/kg and 50 mg/kg could significantly (p < .05) increase the intestinal transit rate, motilin, gastrin, substance P levels, and concentration of short-chain fatty acids (SCFAs), reduce the somatostatin levels, and improve the gastrointestinal peristalsis of rats.	Quercetin	20-29	gastrin	Rattus norvegicus	132-139
34136194-5	2021	The results suggest that Quercetin relieves loperamide-induced constipation by increasing the levels of interstitial cells of Cajal markers (c-Kit and SCF), as well as AQP3.	Quercetin	25-34	KIT ligand	Rattus norvegicus	151-154
34136194-5	2021	The results suggest that Quercetin relieves loperamide-induced constipation by increasing the levels of interstitial cells of Cajal markers (c-Kit and SCF), as well as AQP3.	Quercetin	25-34	aquaporin 3 (Gill blood group)	Rattus norvegicus	168-172
34567171-8	2021	In-silico characterization, suggested that Adenosine diphosphate site (A-site) and quercetin site (Q-Site) in IRE1a enzyme are both available interacting sites of a target for the investigated ligands but with different strengths of interactions.	Quercetin	83-92	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	110-115
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	158-167	interleukin 2	Rattus norvegicus	54-58
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	158-167	interleukin 6	Rattus norvegicus	60-64
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	158-167	tumor necrosis factor	Rattus norvegicus	66-74
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	158-167	mast cell protease 1-like 1	Rattus norvegicus	76-80
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	158-167	C-C motif chemokine ligand 3	Rattus norvegicus	85-95
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	330-339	interleukin 1 alpha	Rattus norvegicus	44-52
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	330-339	interleukin 2	Rattus norvegicus	54-58
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	330-339	interleukin 6	Rattus norvegicus	60-64
34853274-4	2021	These results indicated that quercetin accelerates myocardial relaxation through activation of the sarco-endoplasmic reticulum Ca2+-ATPase.	Quercetin	29-38	ATPase, Ca++ transporting, ubiquitous	Mus musculus	99-138
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	330-339	tumor necrosis factor	Rattus norvegicus	66-74
34161119-0	2021	New perspectives of quercetin and vitamin C effects on fibronectin-binding integrins and chemokine receptors in prostate cancer cell lines.	Quercetin	20-29	fibronectin 1	Homo sapiens	55-66
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	330-339	mast cell protease 1-like 1	Rattus norvegicus	76-80
34161119-3	2021	METHODS: The effect of quercetin (75microM) and vitamin C (100 microM) on CXCR4, CXCR7 chemokine receptors, alpha4, alpha5 and beta1 integrins, ki-67 proliferation marker and Vascular endothelial growth factor, VEGF was evaluated using Quantitative Reverse Transcription PCR (RT-qPCR).	Quercetin	23-32	C-X-C motif chemokine receptor 4	Homo sapiens	74-79
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Quercetin	330-339	C-C motif chemokine ligand 3	Rattus norvegicus	85-95
34161119-3	2021	METHODS: The effect of quercetin (75microM) and vitamin C (100 microM) on CXCR4, CXCR7 chemokine receptors, alpha4, alpha5 and beta1 integrins, ki-67 proliferation marker and Vascular endothelial growth factor, VEGF was evaluated using Quantitative Reverse Transcription PCR (RT-qPCR).	Quercetin	23-32	atypical chemokine receptor 3	Homo sapiens	81-86
34161119-3	2021	METHODS: The effect of quercetin (75microM) and vitamin C (100 microM) on CXCR4, CXCR7 chemokine receptors, alpha4, alpha5 and beta1 integrins, ki-67 proliferation marker and Vascular endothelial growth factor, VEGF was evaluated using Quantitative Reverse Transcription PCR (RT-qPCR).	Quercetin	23-32	vascular endothelial growth factor A	Homo sapiens	211-215
34161119-4	2021	RESULTS: The effect of quercetin and vitamin C alone was different on PC3 and DU145 prostate cancer cell lines, but sequential combination reduced significantly the expression of CXCR and CXCR7 chemokine receptors, alpha4, alpha5 and beta1 integrin subunits, VEGF and Ki-67 proliferation markers in PC3 and DU145 cell lines.	Quercetin	23-32	atypical chemokine receptor 3	Homo sapiens	188-193
34914324-10	2021	Conclusions: Lycopene combined with quercetin and curcumin is more effective than any of the three drugs used alone in the treatment of CP/CPPS, which may be associated with its alleviation of inflammatory response and oxidative stress by interaction between the NF-kappaB, MAPKs and Nrf2 signaling pathways.	Quercetin	36-45	NFE2 like bZIP transcription factor 2	Rattus norvegicus	284-288
34161119-4	2021	RESULTS: The effect of quercetin and vitamin C alone was different on PC3 and DU145 prostate cancer cell lines, but sequential combination reduced significantly the expression of CXCR and CXCR7 chemokine receptors, alpha4, alpha5 and beta1 integrin subunits, VEGF and Ki-67 proliferation markers in PC3 and DU145 cell lines.	Quercetin	23-32	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	215-229
34161119-4	2021	RESULTS: The effect of quercetin and vitamin C alone was different on PC3 and DU145 prostate cancer cell lines, but sequential combination reduced significantly the expression of CXCR and CXCR7 chemokine receptors, alpha4, alpha5 and beta1 integrin subunits, VEGF and Ki-67 proliferation markers in PC3 and DU145 cell lines.	Quercetin	23-32	integrin subunit beta 1	Homo sapiens	234-248
34161119-4	2021	RESULTS: The effect of quercetin and vitamin C alone was different on PC3 and DU145 prostate cancer cell lines, but sequential combination reduced significantly the expression of CXCR and CXCR7 chemokine receptors, alpha4, alpha5 and beta1 integrin subunits, VEGF and Ki-67 proliferation markers in PC3 and DU145 cell lines.	Quercetin	23-32	vascular endothelial growth factor A	Homo sapiens	259-263
34268250-0	2021	Quercetin Synergistically Enhances the Anticancer Efficacy of Docetaxel through Induction of Apoptosis and Modulation of PI3K/AKT, MAPK/ERK, and JAK/STAT3 Signaling Pathways in MDA-MB-231 Breast Cancer Cell Line.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	126-129
34268250-0	2021	Quercetin Synergistically Enhances the Anticancer Efficacy of Docetaxel through Induction of Apoptosis and Modulation of PI3K/AKT, MAPK/ERK, and JAK/STAT3 Signaling Pathways in MDA-MB-231 Breast Cancer Cell Line.	Quercetin	0-9	mitogen-activated protein kinase 1	Homo sapiens	136-139
34268250-0	2021	Quercetin Synergistically Enhances the Anticancer Efficacy of Docetaxel through Induction of Apoptosis and Modulation of PI3K/AKT, MAPK/ERK, and JAK/STAT3 Signaling Pathways in MDA-MB-231 Breast Cancer Cell Line.	Quercetin	0-9	signal transducer and activator of transcription 3	Homo sapiens	149-154
34693792-0	2021	The bioinformatics analysis of quercetin in octagonal lotus for the screening of breast cancer MYC, CXCL10, CXCL11, and E2F1.	Quercetin	31-40	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	95-98
35594707-0	2022	Quercetin ameliorates oxidative stress-induced cell apoptosis of seminal vesicles via activating Nrf2 in type 1 diabetic rats.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	97-101
34693792-0	2021	The bioinformatics analysis of quercetin in octagonal lotus for the screening of breast cancer MYC, CXCL10, CXCL11, and E2F1.	Quercetin	31-40	C-X-C motif chemokine ligand 10	Homo sapiens	100-106
34693792-0	2021	The bioinformatics analysis of quercetin in octagonal lotus for the screening of breast cancer MYC, CXCL10, CXCL11, and E2F1.	Quercetin	31-40	C-X-C motif chemokine ligand 11	Homo sapiens	108-114
34693792-0	2021	The bioinformatics analysis of quercetin in octagonal lotus for the screening of breast cancer MYC, CXCL10, CXCL11, and E2F1.	Quercetin	31-40	E2F transcription factor 1	Homo sapiens	120-124
35447220-7	2022	In addition, immunocytochemistry and subcellular fraction studies indicated an increase of beta-catenin localization in the plasma membrane after QUE treatment.	Quercetin	146-149	catenin beta 1	Homo sapiens	91-103
35352237-5	2022	In this triple coculture, quercetin exposure decreased monocyte adhesion to and macrophage migration through an LPS-stressed endothelium, and this was associated with significantly lower levels of soluble vascular cell adhesion molecule-1 (sVCAM-1).	Quercetin	26-35	vascular cell adhesion molecule 1	Homo sapiens	205-238
35352237-6	2022	Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression.	Quercetin	13-22	tumor necrosis factor	Homo sapiens	124-152
35352237-6	2022	Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression.	Quercetin	13-22	tumor necrosis factor	Homo sapiens	154-163
35352237-6	2022	Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression.	Quercetin	13-22	interleukin 6	Homo sapiens	166-179
35352237-6	2022	Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression.	Quercetin	13-22	interleukin 6	Homo sapiens	181-185
35352237-6	2022	Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression.	Quercetin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	188-201
35352237-6	2022	Furthermore, quercetin decreased the pro-inflammatory cell environment upon LPS-induced endothelial activation, in terms of tumor necrosis factor- alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), and sVCAM-1 expression.	Quercetin	13-22	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
35176713-5	2022	Furthermore, quercetin treatment increased caspase-3 activity and the Bax/Bcl-2 ratio.	Quercetin	13-22	caspase 3	Gallus gallus	43-52
35176713-5	2022	Furthermore, quercetin treatment increased caspase-3 activity and the Bax/Bcl-2 ratio.	Quercetin	13-22	BCL2, apoptosis regulator	Gallus gallus	74-79
35176713-7	2022	In addition, quercetin induced the transition from LC3I to LC3II and increased the expression of ATG7 and Beclin-1.	Quercetin	13-22	autophagy related 7	Gallus gallus	97-101
35176713-7	2022	In addition, quercetin induced the transition from LC3I to LC3II and increased the expression of ATG7 and Beclin-1.	Quercetin	13-22	beclin 1	Gallus gallus	106-114
35176713-8	2022	The PI3K/Akt/mTOR signalling pathway was involved in the induction of autophagy and apoptosis by quercetin.	Quercetin	97-106	mechanistic target of rapamycin	Gallus gallus	13-17
35430443-13	2022	Molecular docking revealed that Quercetin, Moracin D, Moracin E, Moracin G, Moracin H and Moracin B were able to bind stably to AKT1, PTGS2 and ESR1 targets, with Moracin E showing the most stable structure after binding to AKT1.	Quercetin	32-41	AKT serine/threonine kinase 1	Homo sapiens	128-132
35430443-13	2022	Molecular docking revealed that Quercetin, Moracin D, Moracin E, Moracin G, Moracin H and Moracin B were able to bind stably to AKT1, PTGS2 and ESR1 targets, with Moracin E showing the most stable structure after binding to AKT1.	Quercetin	32-41	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139
35430443-13	2022	Molecular docking revealed that Quercetin, Moracin D, Moracin E, Moracin G, Moracin H and Moracin B were able to bind stably to AKT1, PTGS2 and ESR1 targets, with Moracin E showing the most stable structure after binding to AKT1.	Quercetin	32-41	estrogen receptor 1	Homo sapiens	144-148
35430443-13	2022	Molecular docking revealed that Quercetin, Moracin D, Moracin E, Moracin G, Moracin H and Moracin B were able to bind stably to AKT1, PTGS2 and ESR1 targets, with Moracin E showing the most stable structure after binding to AKT1.	Quercetin	32-41	AKT serine/threonine kinase 1	Homo sapiens	224-228
35594707-13	2022	Our results suggested that quercetin could ameliorate oxidative stress-induced cell apoptosis of seminal vesicles via inhibiting Nrf2 in type 1 diabetic rats, which indicated that quercetin could be used for preventing lesions of seminal vesicles in type 1 diabetes.	Quercetin	27-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	129-133
35594707-13	2022	Our results suggested that quercetin could ameliorate oxidative stress-induced cell apoptosis of seminal vesicles via inhibiting Nrf2 in type 1 diabetic rats, which indicated that quercetin could be used for preventing lesions of seminal vesicles in type 1 diabetes.	Quercetin	180-189	NFE2 like bZIP transcription factor 2	Rattus norvegicus	129-133
35623848-6	2022	The bioactive compounds including luteolin, epicatechin, epigallocatechin gallate, lycopene, quercetin, vitamin A, vitamin C and vitamin E in FBV significantly lowered TNF-alpha production, CCL2 production, IL-1beta production, and reactive oxygen species production.	Quercetin	93-102	tumor necrosis factor	Homo sapiens	168-177
35397424-12	2022	The biochemical changes of blood urea nitrogen (BUN), creatinine, and cystatin C were significantly increased in I/R-induced AKI mice, which could be significantly reversed by quercetin polymeric nanoparticles.	Quercetin	176-185	cystatin C	Mus musculus	70-80
35397424-13	2022	Quercetin polymeric nanoparticles could also significantly decrease the histological lesions, positive staining for 3-nitrotyrosine and cyclooxygenase-2, and lipid peroxidation in the kidneys of I/R-induced AKI mice.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	136-152
35212420-0	2022	Quercetin boosts nitric oxide levels and modulates the activities of arginase, acetylcholinesterase and adenosine deaminase in the corpus cavernosum of cyclosporine-treated rats.	Quercetin	0-9	acetylcholinesterase	Rattus norvegicus	79-99
35212420-0	2022	Quercetin boosts nitric oxide levels and modulates the activities of arginase, acetylcholinesterase and adenosine deaminase in the corpus cavernosum of cyclosporine-treated rats.	Quercetin	0-9	adenosine deaminase	Rattus norvegicus	104-123
35587203-7	2022	To probe the role of small-molecule structural features that impede IAPP aggregation, molecular dynamics simulations were performed to observe trimer formation on a model fragment of IAPP(20-29) in the presence of morin, quercetin, dihydroquercetin, epicatechin, and myricetin.	Quercetin	221-230	islet amyloid polypeptide	Homo sapiens	183-187
35366469-13	2022	The binding of five active ingredients originated from Gancao-Banxia to IL-6-STAT3 was verified by molecular docking, namely quercetin, coniferin, licochalcone a, Licoagrocarpin and (3S,6S)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone, maximizing therapeutic efficacy.	Quercetin	125-134	interleukin 6	Homo sapiens	72-76
35366469-13	2022	The binding of five active ingredients originated from Gancao-Banxia to IL-6-STAT3 was verified by molecular docking, namely quercetin, coniferin, licochalcone a, Licoagrocarpin and (3S,6S)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone, maximizing therapeutic efficacy.	Quercetin	125-134	signal transducer and activator of transcription 3	Homo sapiens	77-82
35439707-7	2022	The docking simulation results predicted that (+)-dihydrokaempferol, (+)- dihydroquercetin, (+)-dihydromyricetin, kaempferol, quercetin, myricentin, isoquercitrin, and rutin could bind to at least two subsites (S1, S1", S2, and S4) in the binding pocket and inhibit the activity of SARS-CoV-2 Mpro.	Quercetin	126-135	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	293-297
35122975-0	2022	Quercetin promotes cutaneous wound healing in mice through Wnt/beta-catenin signaling pathway.	Quercetin	0-9	catenin (cadherin associated protein), beta 1	Mus musculus	63-75
35636503-5	2022	We also report discovery that quercetin and other flavonols, though not closely-related flavones, enhance rates of PTPRD"s dephosphorylation of a group of these candidate substrate PTPPs but not others.	Quercetin	30-39	protein tyrosine phosphatase receptor type D	Homo sapiens	115-120
35615960-6	2022	In contrast, the expression of SOD-2 increased by 1.026-fold in the presence of quercetin.	Quercetin	80-89	superoxide dismutase 2	Homo sapiens	31-36
35122975-4	2022	AIM OF THE STUDY: The purpose of this study was to evaluate the healing effect of quercetin on cutaneous wound models in vivo and in vitro, and to reveal the Wnt/beta-catenin pathway and Telomerase reverse transcriptase (TERT) involved mechanisms.	Quercetin	82-91	catenin (cadherin associated protein), beta 1	Mus musculus	162-174
35122975-4	2022	AIM OF THE STUDY: The purpose of this study was to evaluate the healing effect of quercetin on cutaneous wound models in vivo and in vitro, and to reveal the Wnt/beta-catenin pathway and Telomerase reverse transcriptase (TERT) involved mechanisms.	Quercetin	82-91	telomerase reverse transcriptase	Mus musculus	221-225
35122975-8	2022	The molecular docking was adopted to evaluate the binding ability of quercetin and TERT.	Quercetin	69-78	telomerase reverse transcriptase	Mus musculus	83-87
35122975-12	2022	The levels of inflammatory factors, including tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 were significantly reduced after quercetin administration.	Quercetin	144-153	tumor necrosis factor	Mus musculus	46-73
35122975-12	2022	The levels of inflammatory factors, including tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 were significantly reduced after quercetin administration.	Quercetin	144-153	interleukin 1 beta	Mus musculus	75-92
35122975-12	2022	The levels of inflammatory factors, including tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 were significantly reduced after quercetin administration.	Quercetin	144-153	interleukin 6	Mus musculus	97-110
35122975-13	2022	Among which, the level of IL-1beta in cutaneous wound was 0.007 times higher than that of the control group when treated with quercetin of high dose (6.0 mg/mL).	Quercetin	126-135	interleukin 1 alpha	Mus musculus	26-34
35122975-16	2022	The significantly upregulated protein levels of Wnt and beta-catenin further indicated the important role of quercetin in promoting wound healing in mice.	Quercetin	109-118	catenin (cadherin associated protein), beta 1	Mus musculus	56-68
35122975-17	2022	According to molecular docking analysis, the formed hydrogen bonds between quercetin and Ala195, Gln308, Asn369 and Lys372 residues of TERT also indicated the indispensable role of TERT in improving wound healing capacity.	Quercetin	75-84	telomerase reverse transcriptase	Mus musculus	135-139
35122975-17	2022	According to molecular docking analysis, the formed hydrogen bonds between quercetin and Ala195, Gln308, Asn369 and Lys372 residues of TERT also indicated the indispensable role of TERT in improving wound healing capacity.	Quercetin	75-84	telomerase reverse transcriptase	Mus musculus	181-185
35122975-18	2022	CONCLUSION: Quercetin effectively promoted cutaneous wound healing by enhancing the proliferation and migration of fibroblasts, as well as inhibiting inflammation and increasing the expression of growth factors in mice via Wnt/beta-catenin signaling pathway and TERT.	Quercetin	12-21	catenin (cadherin associated protein), beta 1	Mus musculus	227-239
35122975-18	2022	CONCLUSION: Quercetin effectively promoted cutaneous wound healing by enhancing the proliferation and migration of fibroblasts, as well as inhibiting inflammation and increasing the expression of growth factors in mice via Wnt/beta-catenin signaling pathway and TERT.	Quercetin	12-21	telomerase reverse transcriptase	Mus musculus	262-266
35627075-5	2022	Ast and Que significantly reduced LPS-induced production of NO, iNOS, and pro-inflammatory cytokines in the microglia and hippocampus of mice.	Quercetin	8-11	nitric oxide synthase 2, inducible	Mus musculus	64-68
35603834-9	2022	Ferroptosis inhibitors such as ferrostatin-1, liproxstatin-1, quercetin, and melatonin could prevent mitochondrial lipid peroxidation, up-regulate antioxidant/GSH levels and abrogate iron overload-induced apoptosis through activation of Nrf2 and HO-1 signaling pathways.	Quercetin	62-71	NFE2 like bZIP transcription factor 2	Homo sapiens	237-241
35603834-9	2022	Ferroptosis inhibitors such as ferrostatin-1, liproxstatin-1, quercetin, and melatonin could prevent mitochondrial lipid peroxidation, up-regulate antioxidant/GSH levels and abrogate iron overload-induced apoptosis through activation of Nrf2 and HO-1 signaling pathways.	Quercetin	62-71	heme oxygenase 1	Homo sapiens	246-250
35600955-8	2022	Results: The network pharmacology analysis showed that quercetin, luteolin, and kaempferol are the most significant active components in BHHD; STAT3, Jun, AKT1, MAPK3, MAPK1, and TP53 are the most critical drug targets; regulating hormones, reversing insulin (INS) resistance, exerting anti-inflammatory effects, and improving fertility might be the most important mechanisms of BHHD in the treatment of PCOS.	Quercetin	55-64	signal transducer and activator of transcription 3	Homo sapiens	143-148
35578172-0	2022	Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein.	Quercetin	85-94	transmembrane serine protease 2	Homo sapiens	98-105
35578172-0	2022	Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein.	Quercetin	85-94	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	141-146
35578172-7	2022	On the other hand, molecular docking analysis using Schrodinger identified Quercetin as the most potent phyto compound with a maximum binding affinity towards the hydrophilic catalytic site of TMPRSS2 ( - 7.847 kcal/mol) with three hydrogen bonds interaction.	Quercetin	75-84	transmembrane serine protease 2	Homo sapiens	193-200
35578172-10	2022	CONCLUSION: The compounds, Quercetin and Genistein, can inhibit the TMPRSS2 guided priming of the spike protein.	Quercetin	27-36	transmembrane serine protease 2	Homo sapiens	68-75
35578172-10	2022	CONCLUSION: The compounds, Quercetin and Genistein, can inhibit the TMPRSS2 guided priming of the spike protein.	Quercetin	27-36	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	98-103
35578172-12	2022	The critical finding is that compared to Genistein, Quercetin exhibits higher binding affinity with the catalytic unit of TMPRSS2 and forms a stable complex with the target.	Quercetin	52-61	transmembrane serine protease 2	Homo sapiens	122-129
35605401-8	2022	Additionally, quercetin treatment significantly attenuated the expression of fibrogenic genes (TIMP1, ACTA2, COL1A1 and COL3A1) by inhibiting Smad2 phosphorylation.	Quercetin	14-23	collagen type III alpha 1 chain	Homo sapiens	120-126
35605401-8	2022	Additionally, quercetin treatment significantly attenuated the expression of fibrogenic genes (TIMP1, ACTA2, COL1A1 and COL3A1) by inhibiting Smad2 phosphorylation.	Quercetin	14-23	SMAD family member 2	Homo sapiens	142-147
35605401-9	2022	Quercetin suppressed the differentiation of muscle-derived PDGFRalpha+/CD201+ cells to adipocytes and fibroblasts at concentrations achievable by dietary and dietary supplement intake, which indicated its preventive or therapeutic effect against the loss of muscle quality.	Quercetin	0-9	platelet derived growth factor receptor alpha	Homo sapiens	59-69
35605401-7	2022	The quercetin-treated PDGFRalpha+/CD201+ cells showed attenuated lipid accumulation and adipogenic gene expression (CEBPA and ADIPOQ) via the inhibition of CREB phosphorylation under adipocyte differentiation conditions.	Quercetin	4-13	platelet derived growth factor receptor alpha	Homo sapiens	22-32
35605401-7	2022	The quercetin-treated PDGFRalpha+/CD201+ cells showed attenuated lipid accumulation and adipogenic gene expression (CEBPA and ADIPOQ) via the inhibition of CREB phosphorylation under adipocyte differentiation conditions.	Quercetin	4-13	CCAAT enhancer binding protein alpha	Homo sapiens	116-121
35605401-7	2022	The quercetin-treated PDGFRalpha+/CD201+ cells showed attenuated lipid accumulation and adipogenic gene expression (CEBPA and ADIPOQ) via the inhibition of CREB phosphorylation under adipocyte differentiation conditions.	Quercetin	4-13	adiponectin, C1Q and collagen domain containing	Homo sapiens	126-132
35605401-7	2022	The quercetin-treated PDGFRalpha+/CD201+ cells showed attenuated lipid accumulation and adipogenic gene expression (CEBPA and ADIPOQ) via the inhibition of CREB phosphorylation under adipocyte differentiation conditions.	Quercetin	4-13	cAMP responsive element binding protein 1	Homo sapiens	156-160
35605401-8	2022	Additionally, quercetin treatment significantly attenuated the expression of fibrogenic genes (TIMP1, ACTA2, COL1A1 and COL3A1) by inhibiting Smad2 phosphorylation.	Quercetin	14-23	TIMP metallopeptidase inhibitor 1	Homo sapiens	95-100
35605401-8	2022	Additionally, quercetin treatment significantly attenuated the expression of fibrogenic genes (TIMP1, ACTA2, COL1A1 and COL3A1) by inhibiting Smad2 phosphorylation.	Quercetin	14-23	actin alpha 2, smooth muscle	Homo sapiens	102-107
35605401-8	2022	Additionally, quercetin treatment significantly attenuated the expression of fibrogenic genes (TIMP1, ACTA2, COL1A1 and COL3A1) by inhibiting Smad2 phosphorylation.	Quercetin	14-23	collagen type I alpha 1 chain	Homo sapiens	109-115
35600955-8	2022	Results: The network pharmacology analysis showed that quercetin, luteolin, and kaempferol are the most significant active components in BHHD; STAT3, Jun, AKT1, MAPK3, MAPK1, and TP53 are the most critical drug targets; regulating hormones, reversing insulin (INS) resistance, exerting anti-inflammatory effects, and improving fertility might be the most important mechanisms of BHHD in the treatment of PCOS.	Quercetin	55-64	AKT serine/threonine kinase 1	Homo sapiens	155-159
35600955-8	2022	Results: The network pharmacology analysis showed that quercetin, luteolin, and kaempferol are the most significant active components in BHHD; STAT3, Jun, AKT1, MAPK3, MAPK1, and TP53 are the most critical drug targets; regulating hormones, reversing insulin (INS) resistance, exerting anti-inflammatory effects, and improving fertility might be the most important mechanisms of BHHD in the treatment of PCOS.	Quercetin	55-64	mitogen-activated protein kinase 3	Homo sapiens	161-166
35600955-8	2022	Results: The network pharmacology analysis showed that quercetin, luteolin, and kaempferol are the most significant active components in BHHD; STAT3, Jun, AKT1, MAPK3, MAPK1, and TP53 are the most critical drug targets; regulating hormones, reversing insulin (INS) resistance, exerting anti-inflammatory effects, and improving fertility might be the most important mechanisms of BHHD in the treatment of PCOS.	Quercetin	55-64	mitogen-activated protein kinase 1	Homo sapiens	168-173
35600955-8	2022	Results: The network pharmacology analysis showed that quercetin, luteolin, and kaempferol are the most significant active components in BHHD; STAT3, Jun, AKT1, MAPK3, MAPK1, and TP53 are the most critical drug targets; regulating hormones, reversing insulin (INS) resistance, exerting anti-inflammatory effects, and improving fertility might be the most important mechanisms of BHHD in the treatment of PCOS.	Quercetin	55-64	tumor protein p53	Homo sapiens	179-183
35600955-8	2022	Results: The network pharmacology analysis showed that quercetin, luteolin, and kaempferol are the most significant active components in BHHD; STAT3, Jun, AKT1, MAPK3, MAPK1, and TP53 are the most critical drug targets; regulating hormones, reversing insulin (INS) resistance, exerting anti-inflammatory effects, and improving fertility might be the most important mechanisms of BHHD in the treatment of PCOS.	Quercetin	55-64	insulin	Homo sapiens	251-258
35227839-3	2022	Therefore in this study inclusion complexes of Q and R with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) were formulated to improve the aqueous solubility, antiproliferative efficacy and also antioxidant activity of the flavonoids.	Quercetin	47-48	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	96-103
35586682-11	2022	This regulatory effect was related to the expression regulation of HSP90AA1, CDK2, STAT3, and phosphor-STAT3 (p-STAT3) by YQYJ, kaempferol, and quercetin.	Quercetin	144-153	heat shock protein 90 alpha family class A member 1	Homo sapiens	67-75
35586682-11	2022	This regulatory effect was related to the expression regulation of HSP90AA1, CDK2, STAT3, and phosphor-STAT3 (p-STAT3) by YQYJ, kaempferol, and quercetin.	Quercetin	144-153	cyclin dependent kinase 2	Homo sapiens	77-81
35586682-11	2022	This regulatory effect was related to the expression regulation of HSP90AA1, CDK2, STAT3, and phosphor-STAT3 (p-STAT3) by YQYJ, kaempferol, and quercetin.	Quercetin	144-153	signal transducer and activator of transcription 3	Homo sapiens	83-88
35586682-11	2022	This regulatory effect was related to the expression regulation of HSP90AA1, CDK2, STAT3, and phosphor-STAT3 (p-STAT3) by YQYJ, kaempferol, and quercetin.	Quercetin	144-153	signal transducer and activator of transcription 3	Homo sapiens	103-108
35586682-11	2022	This regulatory effect was related to the expression regulation of HSP90AA1, CDK2, STAT3, and phosphor-STAT3 (p-STAT3) by YQYJ, kaempferol, and quercetin.	Quercetin	144-153	signal transducer and activator of transcription 3	Homo sapiens	112-117
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Quercetin	78-87	vascular endothelial growth factor A	Homo sapiens	243-248
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Quercetin	78-87	AKT serine/threonine kinase 1	Homo sapiens	250-254
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Quercetin	78-87	tumor protein p53	Homo sapiens	256-260
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Quercetin	78-87	albumin	Homo sapiens	262-265
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Quercetin	78-87	tumor necrosis factor	Homo sapiens	267-270
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Quercetin	78-87	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	272-278
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Quercetin	78-87	insulin like growth factor 1	Homo sapiens	280-284
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Quercetin	78-87	interleukin 1 beta	Homo sapiens	291-295
35532255-7	2022	By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS.	Quercetin	78-87	phosphatase and tensin homolog	Homo sapiens	297-301
35511410-0	2022	Quercetin: a silent retarder of fatty acid oxidation in breast cancer metastasis through steering of mitochondrial CPT1.	Quercetin	0-9	carnitine palmitoyltransferase 1b, muscle	Mus musculus	115-119
35511410-3	2022	Herein, for the first time, we have introduced quercetin (QT) from a non-dietary source (Mikania micrantha Kunth) to limit the FAO in triple-negative breast cancer cells (TNBC) through an active targeting of CPT1.	Quercetin	47-56	carnitine palmitoyltransferase 1b, muscle	Mus musculus	208-212
35510347-4	2022	Therefore, we fabricated SPI-Dex complexes and used them to stabilize HIPEs-loaded quercetin to explore the interaction mechanism between SPI and Dex and the effect of Dex concentration on the particle size, zeta-potential, microstructure, rheology, quercetin encapsulation efficiency, and gastrointestinal fate of the HIPEs.	Quercetin	83-92	chromogranin A	Homo sapiens	25-28
35510347-4	2022	Therefore, we fabricated SPI-Dex complexes and used them to stabilize HIPEs-loaded quercetin to explore the interaction mechanism between SPI and Dex and the effect of Dex concentration on the particle size, zeta-potential, microstructure, rheology, quercetin encapsulation efficiency, and gastrointestinal fate of the HIPEs.	Quercetin	83-92	chromogranin A	Homo sapiens	138-141
35510347-6	2022	Compared with HIPEs stabilized by SPI, the SPI-Dex complex-stabilized HIPEs had smaller particles (3000.33 +- 201.22 nm) and higher zeta-potential (-21.73 +- 1.10 mV), apparent viscosities, modulus, and quercetin encapsulation efficiency (98.19+-0.14%).	Quercetin	203-212	chromogranin A	Homo sapiens	43-46
35510347-7	2022	In addition, in vitro digestion revealed that SPI-Dex complex-stabilized HIPEs significantly reduced the release of free fatty acid and improved quercetin bioaccessibility.	Quercetin	145-154	chromogranin A	Homo sapiens	46-49
35510347-8	2022	CONCLUSION: HIPEs stabilized by SPI-Dex complexes delayed the release of free fat acid and improved the bioaccessibility of quercetin, may be help in designing delivery systems for bioactive substances with specific properties.	Quercetin	124-133	chromogranin A	Homo sapiens	32-35
35303581-14	2022	The molecular docking results showed that quercetin, kaempferol and wogonin have higher affinity with JUN, RELA and TNF.	Quercetin	42-51	RELA proto-oncogene, NF-kB subunit	Homo sapiens	107-111
35303581-14	2022	The molecular docking results showed that quercetin, kaempferol and wogonin have higher affinity with JUN, RELA and TNF.	Quercetin	42-51	tumor necrosis factor	Homo sapiens	116-119
35430348-6	2022	Importantly, quercetin pretreatment could induce the expression of genes involved in type I interferon (IFN) system (IFN, STAT1, PKR, MxI and ISG15) and TLR9.	Quercetin	13-22	interferon alpha 1	Homo sapiens	104-107
35430348-6	2022	Importantly, quercetin pretreatment could induce the expression of genes involved in type I interferon (IFN) system (IFN, STAT1, PKR, MxI and ISG15) and TLR9.	Quercetin	13-22	interferon alpha 1	Homo sapiens	117-120
35430348-6	2022	Importantly, quercetin pretreatment could induce the expression of genes involved in type I interferon (IFN) system (IFN, STAT1, PKR, MxI and ISG15) and TLR9.	Quercetin	13-22	signal transducer and activator of transcription 1	Homo sapiens	122-127
35416188-5	2022	Apart from creatinine clearance and uric acid with no significant difference, quercetin significantly decreased the levels of renal index, serum/plasma creatinine (SCr), blood urea nitrogen (BUN), urine protein, urine albumin, malondialdehyde (MDA), tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, and increased superoxide dismutase (SOD) and catalase (CAT) activity.	Quercetin	78-87	tumor necrosis factor	Homo sapiens	250-283
35416188-5	2022	Apart from creatinine clearance and uric acid with no significant difference, quercetin significantly decreased the levels of renal index, serum/plasma creatinine (SCr), blood urea nitrogen (BUN), urine protein, urine albumin, malondialdehyde (MDA), tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, and increased superoxide dismutase (SOD) and catalase (CAT) activity.	Quercetin	78-87	interleukin 1 alpha	Homo sapiens	288-310
35416188-5	2022	Apart from creatinine clearance and uric acid with no significant difference, quercetin significantly decreased the levels of renal index, serum/plasma creatinine (SCr), blood urea nitrogen (BUN), urine protein, urine albumin, malondialdehyde (MDA), tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, and increased superoxide dismutase (SOD) and catalase (CAT) activity.	Quercetin	78-87	catalase	Homo sapiens	367-370
35430348-6	2022	Importantly, quercetin pretreatment could induce the expression of genes involved in type I interferon (IFN) system (IFN, STAT1, PKR, MxI and ISG15) and TLR9.	Quercetin	13-22	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	129-132
35337893-0	2022	Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1beta, TNF-alpha, NF-kappaB, IkappaKB, and p53 genes in male Wistar rats.	Quercetin	40-49	interleukin 1 alpha	Rattus norvegicus	139-147
35430348-6	2022	Importantly, quercetin pretreatment could induce the expression of genes involved in type I interferon (IFN) system (IFN, STAT1, PKR, MxI and ISG15) and TLR9.	Quercetin	13-22	MAX interactor 1, dimerization protein	Homo sapiens	134-137
35430348-6	2022	Importantly, quercetin pretreatment could induce the expression of genes involved in type I interferon (IFN) system (IFN, STAT1, PKR, MxI and ISG15) and TLR9.	Quercetin	13-22	ISG15 ubiquitin like modifier	Homo sapiens	142-147
35430348-6	2022	Importantly, quercetin pretreatment could induce the expression of genes involved in type I interferon (IFN) system (IFN, STAT1, PKR, MxI and ISG15) and TLR9.	Quercetin	13-22	toll like receptor 9	Homo sapiens	153-157
35430348-7	2022	It suggested that quercetin exerted the indirect antiviral activity against SGIV infection through promoting the recognition of SGIV and activating the IFN pathway to establish the antiviral status of host cell.	Quercetin	18-27	interferon alpha 1	Homo sapiens	152-155
35436749-3	2022	However, the influence of quercetin on the splenic/immunotoxicity linked with CYP-induced indoleamine 2,3-dioxygenase (IDO) is unavailable in the literature.	Quercetin	26-35	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	119-122
35436749-7	2022	Quercetin co-treatment enhanced activities of antioxidant enzymes, inhibited myeloperoxidase (MPO) activity, lowered levels of nitric oxide, interferon-Upsilon (IFN-Upsilon), and interleukin-6 (IL-6), and reduced kynurenine concentration as well as IDO/TDO activities.	Quercetin	0-9	myeloperoxidase	Rattus norvegicus	77-92
35436749-7	2022	Quercetin co-treatment enhanced activities of antioxidant enzymes, inhibited myeloperoxidase (MPO) activity, lowered levels of nitric oxide, interferon-Upsilon (IFN-Upsilon), and interleukin-6 (IL-6), and reduced kynurenine concentration as well as IDO/TDO activities.	Quercetin	0-9	myeloperoxidase	Rattus norvegicus	94-97
35436749-7	2022	Quercetin co-treatment enhanced activities of antioxidant enzymes, inhibited myeloperoxidase (MPO) activity, lowered levels of nitric oxide, interferon-Upsilon (IFN-Upsilon), and interleukin-6 (IL-6), and reduced kynurenine concentration as well as IDO/TDO activities.	Quercetin	0-9	interleukin 6	Rattus norvegicus	179-192
35436749-7	2022	Quercetin co-treatment enhanced activities of antioxidant enzymes, inhibited myeloperoxidase (MPO) activity, lowered levels of nitric oxide, interferon-Upsilon (IFN-Upsilon), and interleukin-6 (IL-6), and reduced kynurenine concentration as well as IDO/TDO activities.	Quercetin	0-9	interleukin 6	Rattus norvegicus	194-198
35436749-7	2022	Quercetin co-treatment enhanced activities of antioxidant enzymes, inhibited myeloperoxidase (MPO) activity, lowered levels of nitric oxide, interferon-Upsilon (IFN-Upsilon), and interleukin-6 (IL-6), and reduced kynurenine concentration as well as IDO/TDO activities.	Quercetin	0-9	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	249-252
35436749-7	2022	Quercetin co-treatment enhanced activities of antioxidant enzymes, inhibited myeloperoxidase (MPO) activity, lowered levels of nitric oxide, interferon-Upsilon (IFN-Upsilon), and interleukin-6 (IL-6), and reduced kynurenine concentration as well as IDO/TDO activities.	Quercetin	0-9	tryptophan 2,3-dioxygenase	Rattus norvegicus	253-256
35247420-7	2022	Several polyphenols such as resveratrol, epigallocatechin-3-gallate (EGCG) and quercetin enhanced glucose uptake in the muscles and adipocytes by translocating GLUT4 to plasma membrane mainly by the activation of the AMP-activated protein kinase (AMPK) pathway.	Quercetin	79-88	solute carrier family 2 member 4	Homo sapiens	160-165
35337893-0	2022	Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1beta, TNF-alpha, NF-kappaB, IkappaKB, and p53 genes in male Wistar rats.	Quercetin	40-49	tumor necrosis factor	Rattus norvegicus	149-158
35436749-9	2022	In conclusion, quercetin prevented CYP-induced alterations in immune response in rats by lowering the activities of immunosuppressive IDO and TDO, inhibiting oxidative-inflammatory stress, diminution of kynurenine concentrations, and augmenting hematological parameters.	Quercetin	15-24	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	134-137
35436749-9	2022	In conclusion, quercetin prevented CYP-induced alterations in immune response in rats by lowering the activities of immunosuppressive IDO and TDO, inhibiting oxidative-inflammatory stress, diminution of kynurenine concentrations, and augmenting hematological parameters.	Quercetin	15-24	tryptophan 2,3-dioxygenase	Rattus norvegicus	142-145
35337893-0	2022	Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1beta, TNF-alpha, NF-kappaB, IkappaKB, and p53 genes in male Wistar rats.	Quercetin	40-49	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	185-188
35566228-2	2022	Thus, whether the noncovalent interaction between the molecules of two polyphenols (quercetin and fisetin) and two proteins (bovine serum albumin and casein) has positive or negative impact on anticancer activities of the polyphenols against human gastric adenocarcinoma AGS cells was assessed in this study.	Quercetin	84-93	albumin	Homo sapiens	132-145
35093450-0	2022	Quercetin mediates TSC2-RHEB-mTOR pathway to regulate chondrocytes autophagy in knee osteoarthritis.	Quercetin	0-9	TSC complex subunit 2	Rattus norvegicus	19-23
35093450-0	2022	Quercetin mediates TSC2-RHEB-mTOR pathway to regulate chondrocytes autophagy in knee osteoarthritis.	Quercetin	0-9	Ras homolog, mTORC1 binding	Rattus norvegicus	24-28
35093450-0	2022	Quercetin mediates TSC2-RHEB-mTOR pathway to regulate chondrocytes autophagy in knee osteoarthritis.	Quercetin	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	29-33
35093450-9	2022	RESULTS: Quercetin alleviated the joint injury and suppressed the increase in MMP-13 expression and the decreases in collagen and Aggrecan expressions in KOA rats.	Quercetin	9-18	matrix metallopeptidase 13	Rattus norvegicus	78-84
35093450-10	2022	In addition, quercetin suppressed RHEB, p-mTOR, p-YLK1 and P62 expressions but promoted TSC2 and LC3BII expressions in KOA rats.	Quercetin	13-22	Ras homolog, mTORC1 binding	Rattus norvegicus	34-38
35093450-10	2022	In addition, quercetin suppressed RHEB, p-mTOR, p-YLK1 and P62 expressions but promoted TSC2 and LC3BII expressions in KOA rats.	Quercetin	13-22	mechanistic target of rapamycin kinase	Rattus norvegicus	42-46
35093450-10	2022	In addition, quercetin suppressed RHEB, p-mTOR, p-YLK1 and P62 expressions but promoted TSC2 and LC3BII expressions in KOA rats.	Quercetin	13-22	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	59-62
35093450-10	2022	In addition, quercetin suppressed RHEB, p-mTOR, p-YLK1 and P62 expressions but promoted TSC2 and LC3BII expressions in KOA rats.	Quercetin	13-22	TSC complex subunit 2	Rattus norvegicus	88-92
35093450-11	2022	Furthermore, quercetin could relieve the decrease of cell viability and the increase of apoptosis that induced by IL-1beta, and promote the synthesis of IL-1beta-inhibited mucopolysaccharide in chondrocytes.	Quercetin	13-22	interleukin 1 alpha	Rattus norvegicus	114-122
35093450-11	2022	Furthermore, quercetin could relieve the decrease of cell viability and the increase of apoptosis that induced by IL-1beta, and promote the synthesis of IL-1beta-inhibited mucopolysaccharide in chondrocytes.	Quercetin	13-22	interleukin 1 alpha	Rattus norvegicus	153-161
35093450-13	2022	CONCLUSION: Quercetin alleviated KOA by mediating the TSC2-RHBE-mTOR signaling pathway.	Quercetin	12-21	TSC complex subunit 2	Rattus norvegicus	54-58
35093450-13	2022	CONCLUSION: Quercetin alleviated KOA by mediating the TSC2-RHBE-mTOR signaling pathway.	Quercetin	12-21	mechanistic target of rapamycin kinase	Rattus norvegicus	64-68
35430070-5	2022	In addition, pretreatment with two AK inhibitors, rutin and quercetin, significantly decreased the lifespan of beetles treated with deltamethrin.	Quercetin	60-69	arginine kinase	Tribolium castaneum	35-37
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	Quercetin	111-120	caspase 3	Homo sapiens	181-186
35624740-7	2022	The literature reveals that quercetin exhibits anti-COVID-19 activity because of its inhibitory effect on the expression of the human ACE2 receptors and the enzymes of SARS-CoV-2 (MPro, PLPro, and RdRp).	Quercetin	28-37	angiotensin converting enzyme 2	Homo sapiens	134-138
35624740-7	2022	The literature reveals that quercetin exhibits anti-COVID-19 activity because of its inhibitory effect on the expression of the human ACE2 receptors and the enzymes of SARS-CoV-2 (MPro, PLPro, and RdRp).	Quercetin	28-37	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	180-184
35624740-7	2022	The literature reveals that quercetin exhibits anti-COVID-19 activity because of its inhibitory effect on the expression of the human ACE2 receptors and the enzymes of SARS-CoV-2 (MPro, PLPro, and RdRp).	Quercetin	28-37	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	197-201
35571883-0	2022	Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study.	Quercetin	16-25	insulin	Homo sapiens	65-72
35571883-8	2022	Results: The results showed that 7-day quercetin supplementation significantly attenuated the post-exercise glucose-induced insulin response, increased total antioxidant capacity (TAC) and superoxidase dismutase (SOD) activities, and mitigated malondialdehyde (MDA) levels during the recovery period (p < 0.05).	Quercetin	39-48	insulin	Homo sapiens	124-131
35571883-8	2022	Results: The results showed that 7-day quercetin supplementation significantly attenuated the post-exercise glucose-induced insulin response, increased total antioxidant capacity (TAC) and superoxidase dismutase (SOD) activities, and mitigated malondialdehyde (MDA) levels during the recovery period (p < 0.05).	Quercetin	39-48	superoxide dismutase 1	Homo sapiens	189-211
35571883-8	2022	Results: The results showed that 7-day quercetin supplementation significantly attenuated the post-exercise glucose-induced insulin response, increased total antioxidant capacity (TAC) and superoxidase dismutase (SOD) activities, and mitigated malondialdehyde (MDA) levels during the recovery period (p < 0.05).	Quercetin	39-48	superoxide dismutase 1	Homo sapiens	213-216
35571883-11	2022	Conclusion: Our findings concluded that 7-day oral quercetin supplementation enhances high-intensity cycling time to exhaustion, which may be due in part to the increase in whole-body insulin-stimulated glucose uptake and attenuation of exercise-induced oxygen stress and pro-inflammation.	Quercetin	51-60	insulin	Homo sapiens	184-191
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	Quercetin	111-120	prostaglandin-endoperoxide synthase 2	Homo sapiens	174-179
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	Quercetin	111-120	mitogen-activated protein kinase 1	Homo sapiens	188-193
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	Quercetin	111-120	mitogen-activated protein kinase 3	Homo sapiens	195-200
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	Quercetin	111-120	tumor protein p53	Homo sapiens	202-206
35571106-8	2022	Finally, quercetin was identified as a METTL3 inhibitor with an IC50 value of 2.73 muM.	Quercetin	9-18	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	39-45
35559247-12	2022	Molecular docking results showed that Diosgenin, Kaempferol, Quercetin, Hederagenin, Isorhamnetin may act on the related pathways by docking EGFR, IGF1R and INSR.	Quercetin	61-70	epidermal growth factor receptor	Rattus norvegicus	141-145
35571106-12	2022	The values of the root mean square deviation (RMSD), the root mean square fluctuations (RMSF), and binding free energy suggested that quercetin can efficiently bind to the pocket of the METTL3 protein and form a stable protein-ligand complex.	Quercetin	134-143	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	186-192
35528172-5	2022	Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA).	Quercetin	99-108	glutathione-disulfide reductase	Rattus norvegicus	177-198
35528172-5	2022	Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA).	Quercetin	99-108	glutathione-disulfide reductase	Rattus norvegicus	200-202
35528172-5	2022	Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA).	Quercetin	99-108	hematopoietic prostaglandin D synthase	Rattus norvegicus	205-230
35528172-5	2022	Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA).	Quercetin	99-108	hematopoietic prostaglandin D synthase	Rattus norvegicus	232-235
35528172-5	2022	Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA).	Quercetin	99-108	catalase	Rattus norvegicus	296-304
35528172-5	2022	Molecular docking studies and biomarker assessment screening assays proved the potential effect of quercetin to affect the level of representative biomarkers glutathione (GSH), glutathione reductase (GR), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA).	Quercetin	99-108	catalase	Rattus norvegicus	306-309
35559247-12	2022	Molecular docking results showed that Diosgenin, Kaempferol, Quercetin, Hederagenin, Isorhamnetin may act on the related pathways by docking EGFR, IGF1R and INSR.	Quercetin	61-70	insulin-like growth factor 1 receptor	Rattus norvegicus	147-152
35563141-10	2022	While resveratrol and quercetin did not affect MOLT-4 viability, together they enhanced the effect of the genistein/curcumin mix, significantly inhibiting MOLT-4 population growth in vitro.	Quercetin	22-31	transmembrane protein 132D	Homo sapiens	155-159
35559247-12	2022	Molecular docking results showed that Diosgenin, Kaempferol, Quercetin, Hederagenin, Isorhamnetin may act on the related pathways by docking EGFR, IGF1R and INSR.	Quercetin	61-70	insulin receptor	Rattus norvegicus	157-161
35470469-0	2022	Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav-1 signaling.	Quercetin	0-9	caveolin 1	Rattus norvegicus	97-102
35468007-2	2022	Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity.	Quercetin	0-9	insulin	Homo sapiens	106-113
35468007-3	2022	Quercetin appears to affect many factors and signaling pathways involved in insulin resistance and the pathogenesis of type 2 of diabetes.	Quercetin	0-9	insulin	Homo sapiens	76-83
35468007-4	2022	TNFalpha, NFKB, AMPK, AKT, and NRF2 are among the factors that are affected by quercetin.	Quercetin	79-88	tumor necrosis factor	Homo sapiens	0-8
35468007-4	2022	TNFalpha, NFKB, AMPK, AKT, and NRF2 are among the factors that are affected by quercetin.	Quercetin	79-88	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	16-20
35468007-4	2022	TNFalpha, NFKB, AMPK, AKT, and NRF2 are among the factors that are affected by quercetin.	Quercetin	79-88	AKT serine/threonine kinase 1	Homo sapiens	22-25
35593365-12	2022	The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B.	Quercetin	27-36	C-X-C motif chemokine ligand 8	Homo sapiens	74-79
35468007-4	2022	TNFalpha, NFKB, AMPK, AKT, and NRF2 are among the factors that are affected by quercetin.	Quercetin	79-88	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
35468007-7	2022	In this article, after a brief review of the pathogenesis of insulin resistance and type 2 diabetes, we will review the latest findings on the anti-diabetic effects of quercetin with a molecular perspective.	Quercetin	168-177	insulin	Homo sapiens	61-68
35468611-0	2022	Senolytics Cocktail Dasatinib and Quercetin Alleviate Human Umbilical Vein Endothelial Cell Senescence via the TRAF6-MAPK-NF-kappaB Axis in a YTHDF2-Dependent Manner.	Quercetin	34-43	LOC222344	Homo sapiens	111-116
35468611-0	2022	Senolytics Cocktail Dasatinib and Quercetin Alleviate Human Umbilical Vein Endothelial Cell Senescence via the TRAF6-MAPK-NF-kappaB Axis in a YTHDF2-Dependent Manner.	Quercetin	34-43	nuclear factor kappa B subunit 1	Homo sapiens	122-131
35468611-0	2022	Senolytics Cocktail Dasatinib and Quercetin Alleviate Human Umbilical Vein Endothelial Cell Senescence via the TRAF6-MAPK-NF-kappaB Axis in a YTHDF2-Dependent Manner.	Quercetin	34-43	YTH N6-methyladenosine RNA binding protein 2	Homo sapiens	142-148
35547008-0	2022	Quercetin Attenuates Osteoporosis in Orchiectomy Mice by Regulating Glucose and Lipid Metabolism via the GPRC6A/AMPK/mTOR Signaling Pathway.	Quercetin	0-9	G protein-coupled receptor, family C, group 6, member A	Mus musculus	105-111
35547008-0	2022	Quercetin Attenuates Osteoporosis in Orchiectomy Mice by Regulating Glucose and Lipid Metabolism via the GPRC6A/AMPK/mTOR Signaling Pathway.	Quercetin	0-9	mechanistic target of rapamycin kinase	Mus musculus	117-121
35547008-13	2022	Bone metabolism improvement was defined by a reduction of serum levels of insulin, triglycerides, total cholesterol, and low-density lipoprotein, whereas levels of insulin-like growth factor-1 and high-density lipoprotein were increased after quercetin treatment.	Quercetin	243-252	insulin-like growth factor 1	Mus musculus	164-192
35547008-16	2022	In contrast, the phospho-mTOR/mTOR ratio was reduced in the quercetin group.	Quercetin	60-69	mechanistic target of rapamycin kinase	Mus musculus	25-29
35547008-16	2022	In contrast, the phospho-mTOR/mTOR ratio was reduced in the quercetin group.	Quercetin	60-69	mechanistic target of rapamycin kinase	Mus musculus	30-34
35547008-17	2022	Our findings indicate that quercetin can reduce the osteoporosis induced by testosterone deficiency, and its beneficial effects might be associated with the regulation of glucose metabolism and inhibition of lipid metabolism via the GPCR6A/AMPK/mTOR signaling pathway.	Quercetin	27-36	mechanistic target of rapamycin kinase	Mus musculus	245-249
35361431-8	2022	A linear response was obtained within the concentration of 0.005-1.25 mug mL-1 of quercetin.	Quercetin	82-91	L1 cell adhesion molecule	Mus musculus	74-78
35593365-12	2022	The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B.	Quercetin	27-36	C-C motif chemokine ligand 2	Homo sapiens	81-85
35593365-12	2022	The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B.	Quercetin	27-36	interleukin 1 beta	Homo sapiens	89-93
35593365-14	2022	The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01).	Quercetin	61-70	C-X-C motif chemokine ligand 8	Homo sapiens	15-20
35593365-14	2022	The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01).	Quercetin	61-70	C-C motif chemokine ligand 2	Homo sapiens	22-26
35593365-14	2022	The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01).	Quercetin	61-70	interleukin 1 beta	Homo sapiens	30-34
35436022-0	2022	Quercetin attenuates the proliferation of arsenic-related lung cancer cells via a caspase-dependent DNA damage signaling.	Quercetin	0-9	caspase 2	Homo sapiens	82-89
35475990-0	2022	Quercetin inhibits neutrophil extracellular traps release and their cytotoxic effects on A549 cells, as well the release and enzymatic activity of elastase and myeloperoxidase.	Quercetin	0-9	myeloperoxidase	Homo sapiens	160-175
35475990-6	2022	In our in vitro assays, quercetin reduced NETs, myeloperoxidase (MPO), and elastase release from neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA).	Quercetin	24-33	myeloperoxidase	Homo sapiens	48-63
35475990-6	2022	In our in vitro assays, quercetin reduced NETs, myeloperoxidase (MPO), and elastase release from neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA).	Quercetin	24-33	myeloperoxidase	Homo sapiens	65-68
35437774-2	2022	ATZ challenge diminished luteinizing hormone, follicular stimulating hormone, testosterone and myeloperoxidase enzyme activity, but these effects were attenuated on co-treatment with CUR and QUE.	Quercetin	191-194	myeloperoxidase	Rattus norvegicus	95-110
35479514-10	2022	Two compounds in THCQF, aloe emodin (AE) and quercetin (QR), were shown to efficiently bind to cyclin B1, the protein encoded by CCNB1.	Quercetin	45-54	cyclin B1	Homo sapiens	95-104
35479514-10	2022	Two compounds in THCQF, aloe emodin (AE) and quercetin (QR), were shown to efficiently bind to cyclin B1, the protein encoded by CCNB1.	Quercetin	45-54	cyclin B1	Homo sapiens	129-134
35479514-10	2022	Two compounds in THCQF, aloe emodin (AE) and quercetin (QR), were shown to efficiently bind to cyclin B1, the protein encoded by CCNB1.	Quercetin	56-58	cyclin B1	Homo sapiens	95-104
35479514-10	2022	Two compounds in THCQF, aloe emodin (AE) and quercetin (QR), were shown to efficiently bind to cyclin B1, the protein encoded by CCNB1.	Quercetin	56-58	cyclin B1	Homo sapiens	129-134
35475990-9	2022	Further, in silico assays indicated favorable interactions between quercetin and NET proteins (MPO and elastase).	Quercetin	67-76	myeloperoxidase	Homo sapiens	95-111
35475990-10	2022	Overall, our results demonstrate that quercetin decreases deleterious cellular effects of NETs by reducing their release from activated neutrophils, and diminishing the enzymatic activity of MPO and elastase, possibly through direct interaction.	Quercetin	38-47	myeloperoxidase	Homo sapiens	191-207
35436022-8	2022	We also showed that ROS generation induced by quercetin activated caspase-3 to a sufficient level to induce DNA damage but insufficient to induce death in As-treated lung cancer cells.	Quercetin	46-55	caspase 3	Homo sapiens	66-75
35436022-9	2022	Moreover, transient activation of caspase-2 was detected in quercetin- and As-cotreated cells.	Quercetin	60-69	caspase 2	Homo sapiens	34-43
35436022-10	2022	The flow cytometry-based cell cycle analysis showed that the antiproliferative function of quercetin was mediated by S-phase cell cycle arrest, which was associated with upregulation of the Ataxia Telangiectasia-mutated (ATM), but not ATM and RAD3-related.	Quercetin	91-100	ATM serine/threonine kinase	Homo sapiens	190-219
35436022-10	2022	The flow cytometry-based cell cycle analysis showed that the antiproliferative function of quercetin was mediated by S-phase cell cycle arrest, which was associated with upregulation of the Ataxia Telangiectasia-mutated (ATM), but not ATM and RAD3-related.	Quercetin	91-100	ATM serine/threonine kinase	Homo sapiens	221-224
35436022-10	2022	The flow cytometry-based cell cycle analysis showed that the antiproliferative function of quercetin was mediated by S-phase cell cycle arrest, which was associated with upregulation of the Ataxia Telangiectasia-mutated (ATM), but not ATM and RAD3-related.	Quercetin	91-100	ATM serine/threonine kinase	Homo sapiens	235-238
35432570-10	2022	The molecular docking results showed effective ingredients (quercetin, kaempferol, and 7-methoxy-2-methyl isoflavone) have good docking results with targets (IL-6, PTGS2, and TNF).	Quercetin	60-69	tumor necrosis factor	Homo sapiens	175-178
35248552-9	2022	Quercetin remarkably alleviated oxidative stress by reducing malondialdehyde (MDA) and increasing superoxide dismutase (SOD) and catalase (CAT) activities.	Quercetin	0-9	catalase	Homo sapiens	139-142
35248552-10	2022	In addition, quercetin exhibits anti-inflammatory activity by reducing tumor necrosis factor-alpha(TNF-alpha)and interleukin-1beta(IL-1beta)levels.	Quercetin	13-22	tumor necrosis factor	Homo sapiens	71-98
35248552-10	2022	In addition, quercetin exhibits anti-inflammatory activity by reducing tumor necrosis factor-alpha(TNF-alpha)and interleukin-1beta(IL-1beta)levels.	Quercetin	13-22	tumor necrosis factor	Homo sapiens	99-108
35248552-10	2022	In addition, quercetin exhibits anti-inflammatory activity by reducing tumor necrosis factor-alpha(TNF-alpha)and interleukin-1beta(IL-1beta)levels.	Quercetin	13-22	interleukin 1 beta	Homo sapiens	113-130
35248552-10	2022	In addition, quercetin exhibits anti-inflammatory activity by reducing tumor necrosis factor-alpha(TNF-alpha)and interleukin-1beta(IL-1beta)levels.	Quercetin	13-22	interleukin 1 alpha	Homo sapiens	131-139
35455069-10	2022	Oral treatment with quercetin efficiently counteracted the opposing effects of AgNPs on brain tissue via modulation of tight junction proteins, Nrf2, and paraoxonase, and its positive mechanism in modulating pro-inflammatory cytokines and the downregulation of GFAP expression, and the apoptotic pathway.	Quercetin	20-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	144-148
35455069-10	2022	Oral treatment with quercetin efficiently counteracted the opposing effects of AgNPs on brain tissue via modulation of tight junction proteins, Nrf2, and paraoxonase, and its positive mechanism in modulating pro-inflammatory cytokines and the downregulation of GFAP expression, and the apoptotic pathway.	Quercetin	20-29	glial fibrillary acidic protein	Rattus norvegicus	261-265
35432570-10	2022	The molecular docking results showed effective ingredients (quercetin, kaempferol, and 7-methoxy-2-methyl isoflavone) have good docking results with targets (IL-6, PTGS2, and TNF).	Quercetin	60-69	interleukin 6	Homo sapiens	158-162
35432570-10	2022	The molecular docking results showed effective ingredients (quercetin, kaempferol, and 7-methoxy-2-methyl isoflavone) have good docking results with targets (IL-6, PTGS2, and TNF).	Quercetin	60-69	prostaglandin-endoperoxide synthase 2	Homo sapiens	164-169
35384439-0	2022	Quercetin ameliorates renal tubulointerstitial transformation and renal fibrosis by regulating NLRP3 in obstructive nephropathy.	Quercetin	0-9	NLR family pyrin domain containing 3	Homo sapiens	95-100
35384292-0	2022	Quercetin impedes Th17 cell differentiation to mitigate arthritis involving PPARgamma-driven transactivation of SOCS3 and redistribution corepressor SMRT from PPARgamma to STAT3.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Mus musculus	76-85
35422858-13	2022	In addition, we further discovered that quercetin could increase ACC phosphorylation and CPT1alpha expression in PA-induced HepG2 cells.	Quercetin	40-49	carnitine palmitoyltransferase 1A	Homo sapiens	89-98
35422858-14	2022	Conclusions: Our results indicated that quercetin, as the main active component in AMB, exerts an anti-NAFLD effect by regulating the AMPK/MAPK/TNF-alpha and AMPK/ACC/CPT1alpha signaling pathways to inhibit inflammation and alleviate lipid accumulation.	Quercetin	40-49	carnitine palmitoyltransferase 1A	Homo sapiens	167-176
35384292-0	2022	Quercetin impedes Th17 cell differentiation to mitigate arthritis involving PPARgamma-driven transactivation of SOCS3 and redistribution corepressor SMRT from PPARgamma to STAT3.	Quercetin	0-9	suppressor of cytokine signaling 3	Mus musculus	112-117
35384292-0	2022	Quercetin impedes Th17 cell differentiation to mitigate arthritis involving PPARgamma-driven transactivation of SOCS3 and redistribution corepressor SMRT from PPARgamma to STAT3.	Quercetin	0-9	nuclear receptor co-repressor 2	Mus musculus	149-153
35384292-0	2022	Quercetin impedes Th17 cell differentiation to mitigate arthritis involving PPARgamma-driven transactivation of SOCS3 and redistribution corepressor SMRT from PPARgamma to STAT3.	Quercetin	0-9	peroxisome proliferator activated receptor gamma	Mus musculus	159-168
35384292-0	2022	Quercetin impedes Th17 cell differentiation to mitigate arthritis involving PPARgamma-driven transactivation of SOCS3 and redistribution corepressor SMRT from PPARgamma to STAT3.	Quercetin	0-9	signal transducer and activator of transcription 3	Mus musculus	172-177
35385884-0	2022	Quercetin and Methotrexate in Combination have Anticancer Activity in Osteosarcoma Cells and Repress Oncogenic MicroRNA-223.	Quercetin	0-9	microRNA 223	Homo sapiens	111-123
35571420-18	2022	The active compounds mainly included quercetin, kaempferol, formononetin, and luteolin, which had good docking scores and targeted the AKT protein.	Quercetin	37-46	AKT serine/threonine kinase 1	Rattus norvegicus	135-138
35412948-0	2022	Quercetin inhibits fibroblasts proliferation and reduces surgery-induced epidural fibrosis via the autophagy-mediated PI3K/Akt/mTOR pathway.	Quercetin	0-9	AKT serine/threonine kinase 1	Homo sapiens	123-126
35412948-0	2022	Quercetin inhibits fibroblasts proliferation and reduces surgery-induced epidural fibrosis via the autophagy-mediated PI3K/Akt/mTOR pathway.	Quercetin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	127-131
35067813-6	2022	RESULTS: The results showed that the levels of mRNA expression of TGF-beta, alphaSMA, Collagen1 genes, and phosphorylated smad3 protein were significantly reduced in fructose-activated HSCs after treatment with Quercetin compared to fructose-activated HSCs.	Quercetin	211-220	transforming growth factor alpha	Homo sapiens	66-74
35331526-10	2022	Beta-catenin and Bcl-2 proteins expression was decreased and caspase 3 expression was significantly increased in the quercetin group versus to control group.	Quercetin	117-126	catenin beta 1	Rattus norvegicus	0-12
35331526-10	2022	Beta-catenin and Bcl-2 proteins expression was decreased and caspase 3 expression was significantly increased in the quercetin group versus to control group.	Quercetin	117-126	BCL2, apoptosis regulator	Rattus norvegicus	17-22
35331526-10	2022	Beta-catenin and Bcl-2 proteins expression was decreased and caspase 3 expression was significantly increased in the quercetin group versus to control group.	Quercetin	117-126	caspase 3	Rattus norvegicus	61-70
35331526-12	2022	The quercetin supplementation lead to increase in apoptotic proteins gene expression including caspase 3 and decrease in anti-apoptotic gene expression including Bcl-2.	Quercetin	4-13	caspase 3	Rattus norvegicus	95-104
35331526-12	2022	The quercetin supplementation lead to increase in apoptotic proteins gene expression including caspase 3 and decrease in anti-apoptotic gene expression including Bcl-2.	Quercetin	4-13	BCL2, apoptosis regulator	Rattus norvegicus	162-167
35094209-11	2022	Moreover, the results of the molecular analysis revealed that quercetin treatment significantly (p < 0.01) decrease TNF-alpha and IL-1beta levels as compared to LPS treated animals.	Quercetin	62-71	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	116-125
35442463-17	2022	CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD.	Quercetin	26-35	interleukin 6	Homo sapiens	87-91
35442463-17	2022	CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD.	Quercetin	26-35	estrogen receptor 1	Homo sapiens	93-97
35442463-17	2022	CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD.	Quercetin	26-35	epidermal growth factor receptor	Homo sapiens	99-103
35442463-17	2022	CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD.	Quercetin	26-35	mitogen-activated protein kinase 8	Homo sapiens	105-110
35442463-17	2022	CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD.	Quercetin	26-35	vascular endothelial growth factor A	Homo sapiens	112-117
35442463-17	2022	CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD.	Quercetin	26-35	caspase 8	Homo sapiens	122-127
35442463-17	2022	CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD.	Quercetin	26-35	AKT serine/threonine kinase 1	Homo sapiens	219-222
35442463-17	2022	CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD.	Quercetin	26-35	tumor necrosis factor	Homo sapiens	246-249
35187760-12	2022	Thymoquinone and quercetin not only reduced acrylamide-induced apoptosis in annexin V and caspase 3/7 assays but also morphological deformations in microscopic examinations.	Quercetin	17-26	annexin A5	Rattus norvegicus	76-85
35187760-12	2022	Thymoquinone and quercetin not only reduced acrylamide-induced apoptosis in annexin V and caspase 3/7 assays but also morphological deformations in microscopic examinations.	Quercetin	17-26	caspase 3	Rattus norvegicus	90-101
35187760-14	2022	As for Nrf2 expression, it was observed that acrylamide increased Nrf2 expression, and thymoquinone and quercetin pretreatments increased it even further.	Quercetin	104-113	NFE2 like bZIP transcription factor 2	Rattus norvegicus	7-11
35438554-11	2022	Molecular docking showed that the active components of HCT (quercetin and kaempferol) had similar binding affinities for SARS-CoV-2 3CLpro and SARS-CoV-2 RdRp, primary COVID-19 target proteins as did clinically used drugs.	Quercetin	60-69	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	154-158
35067813-6	2022	RESULTS: The results showed that the levels of mRNA expression of TGF-beta, alphaSMA, Collagen1 genes, and phosphorylated smad3 protein were significantly reduced in fructose-activated HSCs after treatment with Quercetin compared to fructose-activated HSCs.	Quercetin	211-220	actin alpha 1, skeletal muscle	Homo sapiens	76-84
35067813-6	2022	RESULTS: The results showed that the levels of mRNA expression of TGF-beta, alphaSMA, Collagen1 genes, and phosphorylated smad3 protein were significantly reduced in fructose-activated HSCs after treatment with Quercetin compared to fructose-activated HSCs.	Quercetin	211-220	SMAD family member 3	Homo sapiens	122-127
35067813-7	2022	CONCLUSION: Quercetin is effective in reducing the expression of fibrogenic genes in fructose-activated human HSCs through downregulation of the TGF-beta/smad3 signaling pathway.	Quercetin	12-21	transforming growth factor alpha	Homo sapiens	145-153
35067813-7	2022	CONCLUSION: Quercetin is effective in reducing the expression of fibrogenic genes in fructose-activated human HSCs through downregulation of the TGF-beta/smad3 signaling pathway.	Quercetin	12-21	SMAD family member 3	Homo sapiens	154-159
35432205-16	2022	Importantly, in immune-deficient mice transplanted with fat from obese patients, dasatinib plus quercetin, a senolytic cocktail that reduces the number of both p21 high and p16 high cells, improves both glucose tolerance and insulin resistance.	Quercetin	96-105	H3 histone pseudogene 16	Homo sapiens	160-163
35051607-13	2022	Moreover, our findings suggest that quercetin can reduce fibrogenic markers of activated HSCs as well as osteopontin expression, a target gene of hedgehog signaling.	Quercetin	36-45	secreted phosphoprotein 1	Homo sapiens	105-116
35402622-14	2022	Subsequently, we observed that adding 1*10-6 mol/L quercetin, 1*10-5  mol/L kaempferol, and 1*10-5  mol/L beta-carotene activated the ERK/JNK cascades and the heterodimer complex AP-1(Fos/Jun) in the MAPK pathway.	Quercetin	51-60	mitogen-activated protein kinase 1	Mus musculus	134-137
35402622-14	2022	Subsequently, we observed that adding 1*10-6 mol/L quercetin, 1*10-5  mol/L kaempferol, and 1*10-5  mol/L beta-carotene activated the ERK/JNK cascades and the heterodimer complex AP-1(Fos/Jun) in the MAPK pathway.	Quercetin	51-60	mitogen-activated protein kinase 8	Mus musculus	138-141
35402622-14	2022	Subsequently, we observed that adding 1*10-6 mol/L quercetin, 1*10-5  mol/L kaempferol, and 1*10-5  mol/L beta-carotene activated the ERK/JNK cascades and the heterodimer complex AP-1(Fos/Jun) in the MAPK pathway.	Quercetin	51-60	jun proto-oncogene	Mus musculus	179-183
35402622-14	2022	Subsequently, we observed that adding 1*10-6 mol/L quercetin, 1*10-5  mol/L kaempferol, and 1*10-5  mol/L beta-carotene activated the ERK/JNK cascades and the heterodimer complex AP-1(Fos/Jun) in the MAPK pathway.	Quercetin	51-60	FBJ osteosarcoma oncogene	Mus musculus	184-187
35432205-16	2022	Importantly, in immune-deficient mice transplanted with fat from obese patients, dasatinib plus quercetin, a senolytic cocktail that reduces the number of both p21 high and p16 high cells, improves both glucose tolerance and insulin resistance.	Quercetin	96-105	cyclin dependent kinase inhibitor 2A	Homo sapiens	173-176
35432205-16	2022	Importantly, in immune-deficient mice transplanted with fat from obese patients, dasatinib plus quercetin, a senolytic cocktail that reduces the number of both p21 high and p16 high cells, improves both glucose tolerance and insulin resistance.	Quercetin	96-105	insulin	Homo sapiens	225-232
35454970-6	2022	Specific checkpoints identified in managing SARS-CoV-2 induced cytokine storm include a decrease in the level of Nod-Like Receptor 3 (NLRP3) inflammasome where drugs such as quercetin and anakinra were effective.	Quercetin	174-183	NLR family pyrin domain containing 3	Homo sapiens	134-139
35402265-11	2022	We further described the therapeutic potential of Bax/Bcl-2/EGFR SMIs, mainly those with more potent and selectivity, including gefitinib, EGCG, ABT-737, thymoquinone, quercetin, and venetoclax.	Quercetin	168-177	BCL2 associated X, apoptosis regulator	Homo sapiens	50-53
35454970-7	2022	Janus kinase-2 and signal transducer and activator of transcription-1 (JAK2/STAT1) signaling pathways were blocked by medicines such as tocilizumab, baricitinib, and quercetin.	Quercetin	166-175	Janus kinase 2	Homo sapiens	0-14
35454970-7	2022	Janus kinase-2 and signal transducer and activator of transcription-1 (JAK2/STAT1) signaling pathways were blocked by medicines such as tocilizumab, baricitinib, and quercetin.	Quercetin	166-175	signal transducer and activator of transcription 1	Homo sapiens	19-69
35454970-7	2022	Janus kinase-2 and signal transducer and activator of transcription-1 (JAK2/STAT1) signaling pathways were blocked by medicines such as tocilizumab, baricitinib, and quercetin.	Quercetin	166-175	Janus kinase 2	Homo sapiens	71-75
35454970-7	2022	Janus kinase-2 and signal transducer and activator of transcription-1 (JAK2/STAT1) signaling pathways were blocked by medicines such as tocilizumab, baricitinib, and quercetin.	Quercetin	166-175	signal transducer and activator of transcription 1	Homo sapiens	76-81
35355655-14	2022	In addition, IL6 and Quercetin could form a stable complex with high binding affinity (-7.29 kcal/mol).	Quercetin	21-30	interleukin 6	Rattus norvegicus	13-16
35325306-11	2022	Compared with control group, quercetin group had a higher weight retention rate, a higher gene/protein expression of SIRT1, HSP60, UCP1, PPAR-gamma and VEGF-A, and a higher occurrence of peripheral adipose browning.	Quercetin	29-38	sirtuin 1	Homo sapiens	117-122
35325306-11	2022	Compared with control group, quercetin group had a higher weight retention rate, a higher gene/protein expression of SIRT1, HSP60, UCP1, PPAR-gamma and VEGF-A, and a higher occurrence of peripheral adipose browning.	Quercetin	29-38	heat shock protein family D (Hsp60) member 1	Homo sapiens	124-129
35325306-11	2022	Compared with control group, quercetin group had a higher weight retention rate, a higher gene/protein expression of SIRT1, HSP60, UCP1, PPAR-gamma and VEGF-A, and a higher occurrence of peripheral adipose browning.	Quercetin	29-38	uncoupling protein 1	Homo sapiens	131-135
35325306-11	2022	Compared with control group, quercetin group had a higher weight retention rate, a higher gene/protein expression of SIRT1, HSP60, UCP1, PPAR-gamma and VEGF-A, and a higher occurrence of peripheral adipose browning.	Quercetin	29-38	peroxisome proliferator activated receptor gamma	Homo sapiens	137-147
35325306-11	2022	Compared with control group, quercetin group had a higher weight retention rate, a higher gene/protein expression of SIRT1, HSP60, UCP1, PPAR-gamma and VEGF-A, and a higher occurrence of peripheral adipose browning.	Quercetin	29-38	vascular endothelial growth factor A	Homo sapiens	152-158
35453307-9	2022	Transcriptomic analysis of apigenin and quercetin uncovered that high-dose flavonoids activated TNF-alpha signaling, as verified through detecting inflammatory gene levels in breast cancer cells and RAW 264.7 macrophages.	Quercetin	40-49	tumor necrosis factor	Homo sapiens	96-105
35408818-6	2022	Accordingly, FK866, a NAMPT inhibitor, and quercetin, a Sirt1 agonist, have favorable effects on the maintenance of NAD+ homeostasis and renal function in db/db mice.	Quercetin	43-52	sirtuin 1	Mus musculus	56-61
35368759-10	2022	Specifically, the active ingredients of XFC, including quercetin, kaempferol, triptolide, and formononetin, inhibited the inflammatory response in AS by downregulating TNF and PTGS2 in the TNF and NF-kappaB signaling pathways.	Quercetin	55-64	tumor necrosis factor	Homo sapiens	168-171
35368759-10	2022	Specifically, the active ingredients of XFC, including quercetin, kaempferol, triptolide, and formononetin, inhibited the inflammatory response in AS by downregulating TNF and PTGS2 in the TNF and NF-kappaB signaling pathways.	Quercetin	55-64	prostaglandin-endoperoxide synthase 2	Homo sapiens	176-181
35368759-10	2022	Specifically, the active ingredients of XFC, including quercetin, kaempferol, triptolide, and formononetin, inhibited the inflammatory response in AS by downregulating TNF and PTGS2 in the TNF and NF-kappaB signaling pathways.	Quercetin	55-64	tumor necrosis factor	Homo sapiens	189-192
35368759-8	2022	Quercetin, kaempferol, triptolide, and formononetin had free binding energies < -9 kcal/mol to inflammatory targets (TNF and PTGS2) in the molecular docking analysis of XFC-active ingredients, indicating that TNF and PTGS2 might be the targets of the action of XFC.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	117-120
35368759-8	2022	Quercetin, kaempferol, triptolide, and formononetin had free binding energies < -9 kcal/mol to inflammatory targets (TNF and PTGS2) in the molecular docking analysis of XFC-active ingredients, indicating that TNF and PTGS2 might be the targets of the action of XFC.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	125-130
35368759-8	2022	Quercetin, kaempferol, triptolide, and formononetin had free binding energies < -9 kcal/mol to inflammatory targets (TNF and PTGS2) in the molecular docking analysis of XFC-active ingredients, indicating that TNF and PTGS2 might be the targets of the action of XFC.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	209-212
35368759-8	2022	Quercetin, kaempferol, triptolide, and formononetin had free binding energies < -9 kcal/mol to inflammatory targets (TNF and PTGS2) in the molecular docking analysis of XFC-active ingredients, indicating that TNF and PTGS2 might be the targets of the action of XFC.	Quercetin	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	217-222
35313329-8	2022	Gene expression profile of quercetin treated rats revealed down regulation of HGF, TIMP1 and MMP2 expressed during CCl4 induction.	Quercetin	27-36	hepatocyte growth factor	Rattus norvegicus	78-81
35175047-0	2022	Bovine Serum Albumin as a Potential Carrier for the Protection of Bioactive Quercetin and Inhibition of Cu(II) Toxicity.	Quercetin	76-85	albumin	Homo sapiens	7-20
35175047-2	2022	In this study, the interaction between quercetin (a major flavonoid in the human diet) and bovine serum albumin (BSA) was investigated in the absence and presence of free Cu(II).	Quercetin	39-48	albumin	Homo sapiens	98-111
35431500-0	2022	Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-alpha-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	58-85
35431500-0	2022	Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-alpha-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells.	Quercetin	0-9	matrix metallopeptidase 9	Homo sapiens	94-120
35431500-5	2022	AIM: To assess whether tumor necrosis factor-alpha (TNF-alpha)-induced MMP-9 expression mediates the anti-inflammatory effects of quercetin in normal human gastric mucosal epithelial cells.	Quercetin	130-139	matrix metallopeptidase 9	Homo sapiens	71-76
35431500-18	2022	CONCLUSION: Quercetin significantly downregulates TNF-alpha-induced MMP-9 expression in GES-1 cells via the TNFR-c-Src-ERK1/2 and c-Fos or NF-kappaB pathways.	Quercetin	12-21	tumor necrosis factor	Homo sapiens	50-59
35431500-18	2022	CONCLUSION: Quercetin significantly downregulates TNF-alpha-induced MMP-9 expression in GES-1 cells via the TNFR-c-Src-ERK1/2 and c-Fos or NF-kappaB pathways.	Quercetin	12-21	matrix metallopeptidase 9	Homo sapiens	68-73
35431500-18	2022	CONCLUSION: Quercetin significantly downregulates TNF-alpha-induced MMP-9 expression in GES-1 cells via the TNFR-c-Src-ERK1/2 and c-Fos or NF-kappaB pathways.	Quercetin	12-21	TNF receptor superfamily member 1A	Homo sapiens	108-112
35431500-18	2022	CONCLUSION: Quercetin significantly downregulates TNF-alpha-induced MMP-9 expression in GES-1 cells via the TNFR-c-Src-ERK1/2 and c-Fos or NF-kappaB pathways.	Quercetin	12-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	113-118
35431500-18	2022	CONCLUSION: Quercetin significantly downregulates TNF-alpha-induced MMP-9 expression in GES-1 cells via the TNFR-c-Src-ERK1/2 and c-Fos or NF-kappaB pathways.	Quercetin	12-21	mitogen-activated protein kinase 3	Homo sapiens	119-125
35431500-18	2022	CONCLUSION: Quercetin significantly downregulates TNF-alpha-induced MMP-9 expression in GES-1 cells via the TNFR-c-Src-ERK1/2 and c-Fos or NF-kappaB pathways.	Quercetin	12-21	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-135
35431500-18	2022	CONCLUSION: Quercetin significantly downregulates TNF-alpha-induced MMP-9 expression in GES-1 cells via the TNFR-c-Src-ERK1/2 and c-Fos or NF-kappaB pathways.	Quercetin	12-21	nuclear factor kappa B subunit 1	Homo sapiens	139-148
35431500-6	2022	METHODS: The normal human gastric mucosa epithelial cell line GES-1 was used to establish a normal human gastric epithelial cell model of TNF-alpha-induced MMP-9 protein overexpression to evaluate the anti-inflammatory effects of quercetin.	Quercetin	230-239	tumor necrosis factor	Homo sapiens	138-147
35431500-6	2022	METHODS: The normal human gastric mucosa epithelial cell line GES-1 was used to establish a normal human gastric epithelial cell model of TNF-alpha-induced MMP-9 protein overexpression to evaluate the anti-inflammatory effects of quercetin.	Quercetin	230-239	matrix metallopeptidase 9	Homo sapiens	156-161
35431500-13	2022	These effects were reduced by the pretreatment of GES-1 cells with quercetin or a TNF-alpha antagonist (TNFR inhibitor) in a dose- and time-dependent manner.	Quercetin	67-76	TNF receptor superfamily member 1A	Homo sapiens	104-108
35313329-8	2022	Gene expression profile of quercetin treated rats revealed down regulation of HGF, TIMP1 and MMP2 expressed during CCl4 induction.	Quercetin	27-36	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	83-88
35431500-14	2022	Quercetin and TNF-alpha antagonists decreased the TNF-alpha-induced phosphorylation of c-Src, ERK1/2, c-Fos, and p65 in a dose- and time-dependent manner.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	50-59
35431500-14	2022	Quercetin and TNF-alpha antagonists decreased the TNF-alpha-induced phosphorylation of c-Src, ERK1/2, c-Fos, and p65 in a dose- and time-dependent manner.	Quercetin	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	87-92
35313329-8	2022	Gene expression profile of quercetin treated rats revealed down regulation of HGF, TIMP1 and MMP2 expressed during CCl4 induction.	Quercetin	27-36	matrix metallopeptidase 2	Rattus norvegicus	93-97
35431500-14	2022	Quercetin and TNF-alpha antagonists decreased the TNF-alpha-induced phosphorylation of c-Src, ERK1/2, c-Fos, and p65 in a dose- and time-dependent manner.	Quercetin	0-9	mitogen-activated protein kinase 3	Homo sapiens	94-100
35431500-14	2022	Quercetin and TNF-alpha antagonists decreased the TNF-alpha-induced phosphorylation of c-Src, ERK1/2, c-Fos, and p65 in a dose- and time-dependent manner.	Quercetin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-107
35313329-9	2022	In silico molecular mechanism prediction suggested that quercetin has a high affinity for cell signaling pathway proteins BCL-2, JAK2 and Cytochrome P450 Cyp2E1, which all play a significant role in CCl4 induced hepatotoxicity.	Quercetin	56-65	BCL2, apoptosis regulator	Rattus norvegicus	122-127
35431500-14	2022	Quercetin and TNF-alpha antagonists decreased the TNF-alpha-induced phosphorylation of c-Src, ERK1/2, c-Fos, and p65 in a dose- and time-dependent manner.	Quercetin	0-9	RELA proto-oncogene, NF-kB subunit	Homo sapiens	113-116
35313329-9	2022	In silico molecular mechanism prediction suggested that quercetin has a high affinity for cell signaling pathway proteins BCL-2, JAK2 and Cytochrome P450 Cyp2E1, which all play a significant role in CCl4 induced hepatotoxicity.	Quercetin	56-65	Janus kinase 2	Rattus norvegicus	129-133
35431500-15	2022	Quercetin, TNF-alpha antagonist, PP1, U0126, and tanshinone IIA (TSIIA) reduced TNF-alpha-induced c-Fos phosphorylation and AP-1-Luciferase (Luc) activity in a dose- and time-dependent manner.	Quercetin	0-9	tumor necrosis factor	Homo sapiens	80-89
35431500-15	2022	Quercetin, TNF-alpha antagonist, PP1, U0126, and tanshinone IIA (TSIIA) reduced TNF-alpha-induced c-Fos phosphorylation and AP-1-Luciferase (Luc) activity in a dose- and time-dependent manner.	Quercetin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103
35431500-16	2022	Pretreatment with quercetin, TNF-alpha antagonist, PP1, U0126, or Bay 11-7082 reduced TNF-alpha-induced p65 phosphorylation and translocation and p65-Luc activity in a dose- and time-dependent manner.	Quercetin	18-27	tumor necrosis factor	Homo sapiens	86-95
35431500-16	2022	Pretreatment with quercetin, TNF-alpha antagonist, PP1, U0126, or Bay 11-7082 reduced TNF-alpha-induced p65 phosphorylation and translocation and p65-Luc activity in a dose- and time-dependent manner.	Quercetin	18-27	RELA proto-oncogene, NF-kB subunit	Homo sapiens	104-107
35431500-17	2022	TNF-alpha significantly increased GES-1 cell migration, and these results were reduced by pretreatment with quercetin or a TNF-alpha antagonist.	Quercetin	108-117	tumor necrosis factor	Homo sapiens	0-9
35313329-11	2022	MMGBSA studies have revealed high binding of quercetin (DeltaG) -41.48+-11.02, -43.53+-6.55 and -39.89+-5.78 kcal/mol, with BCL-2, JAK2 and Cyp2E1, respectively which led to better stability of the quercetin bound protein complexes.	Quercetin	45-54	BCL2, apoptosis regulator	Rattus norvegicus	124-129
35313329-11	2022	MMGBSA studies have revealed high binding of quercetin (DeltaG) -41.48+-11.02, -43.53+-6.55 and -39.89+-5.78 kcal/mol, with BCL-2, JAK2 and Cyp2E1, respectively which led to better stability of the quercetin bound protein complexes.	Quercetin	45-54	Janus kinase 2	Rattus norvegicus	131-135
35313329-11	2022	MMGBSA studies have revealed high binding of quercetin (DeltaG) -41.48+-11.02, -43.53+-6.55 and -39.89+-5.78 kcal/mol, with BCL-2, JAK2 and Cyp2E1, respectively which led to better stability of the quercetin bound protein complexes.	Quercetin	45-54	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	140-146
35313329-11	2022	MMGBSA studies have revealed high binding of quercetin (DeltaG) -41.48+-11.02, -43.53+-6.55 and -39.89+-5.78 kcal/mol, with BCL-2, JAK2 and Cyp2E1, respectively which led to better stability of the quercetin bound protein complexes.	Quercetin	198-207	BCL2, apoptosis regulator	Rattus norvegicus	124-129
35313329-12	2022	Therefore, quercetin can act as potent inhibitor against CCl4 induced hepatic injury by regulating BCL-2, JAK2 and Cyp2E1.	Quercetin	11-20	BCL2, apoptosis regulator	Rattus norvegicus	99-104
35313329-12	2022	Therefore, quercetin can act as potent inhibitor against CCl4 induced hepatic injury by regulating BCL-2, JAK2 and Cyp2E1.	Quercetin	11-20	Janus kinase 2	Rattus norvegicus	106-110
35313329-12	2022	Therefore, quercetin can act as potent inhibitor against CCl4 induced hepatic injury by regulating BCL-2, JAK2 and Cyp2E1.	Quercetin	11-20	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	115-121
35372072-11	2022	Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway.	Quercetin	76-85	prostaglandin-endoperoxide synthase 2	Homo sapiens	144-181
35372072-13	2022	The results showed that luteolin and quercetin increased the expression of PTGS2 and MMP9 and reduced the expression of CCL2 in HaCaT cells treated with gefitinib.	Quercetin	37-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	75-80
35372072-13	2022	The results showed that luteolin and quercetin increased the expression of PTGS2 and MMP9 and reduced the expression of CCL2 in HaCaT cells treated with gefitinib.	Quercetin	37-46	matrix metallopeptidase 9	Homo sapiens	85-89
35372072-11	2022	Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway.	Quercetin	76-85	prostaglandin-endoperoxide synthase 2	Mus musculus	183-188
35372072-13	2022	The results showed that luteolin and quercetin increased the expression of PTGS2 and MMP9 and reduced the expression of CCL2 in HaCaT cells treated with gefitinib.	Quercetin	37-46	C-C motif chemokine ligand 2	Homo sapiens	120-124
35372072-11	2022	Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway.	Quercetin	76-85	matrix metallopeptidase 9	Homo sapiens	191-216
35372072-15	2022	Luteolin and quercetin may be the core active ingredients of QYSLS in the treatment of EGFRI-related adverse skin reactions, and their therapeutic effects are potentially mediated through PTGS2, CCL2, and MMP9 in the IL-17 and TNF signaling pathway.	Quercetin	13-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	188-193
35372072-15	2022	Luteolin and quercetin may be the core active ingredients of QYSLS in the treatment of EGFRI-related adverse skin reactions, and their therapeutic effects are potentially mediated through PTGS2, CCL2, and MMP9 in the IL-17 and TNF signaling pathway.	Quercetin	13-22	C-C motif chemokine ligand 2	Homo sapiens	195-199
35372072-11	2022	Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway.	Quercetin	76-85	matrix metallopeptidase 9	Mus musculus	218-222
35372072-15	2022	Luteolin and quercetin may be the core active ingredients of QYSLS in the treatment of EGFRI-related adverse skin reactions, and their therapeutic effects are potentially mediated through PTGS2, CCL2, and MMP9 in the IL-17 and TNF signaling pathway.	Quercetin	13-22	matrix metallopeptidase 9	Homo sapiens	205-209
35372072-15	2022	Luteolin and quercetin may be the core active ingredients of QYSLS in the treatment of EGFRI-related adverse skin reactions, and their therapeutic effects are potentially mediated through PTGS2, CCL2, and MMP9 in the IL-17 and TNF signaling pathway.	Quercetin	13-22	interleukin 17A	Homo sapiens	217-222
35372072-11	2022	Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway.	Quercetin	76-85	C-C motif chemokine ligand 2	Homo sapiens	229-257
35372072-11	2022	Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway.	Quercetin	76-85	chemokine (C-C motif) ligand 2	Mus musculus	259-263
35372072-11	2022	Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway.	Quercetin	76-85	interleukin 17A	Homo sapiens	285-299
35372072-11	2022	Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway.	Quercetin	76-85	interleukin 17A	Homo sapiens	301-306
35372072-11	2022	Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway.	Quercetin	76-85	tumor necrosis factor	Homo sapiens	312-333
35372072-11	2022	Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway.	Quercetin	76-85	tumor necrosis factor	Homo sapiens	335-338
35238254-6	2022	In this context, phenolic compounds (catechins, quercetin, and chrysin) are the most extensively BCs studied and encapsulated in albumin-based nanocarriers.	Quercetin	48-57	albumin	Homo sapiens	129-136
35286330-6	2022	with 25muM quercetin significantly increased PON2 protein levels: 15.5 treated cells vs. 9.8 untreated cells (relative units normalized by GAPDH) (p value = 0.004).	Quercetin	11-20	paraoxonase 2	Homo sapiens	45-49
35286330-6	2022	with 25muM quercetin significantly increased PON2 protein levels: 15.5 treated cells vs. 9.8 untreated cells (relative units normalized by GAPDH) (p value = 0.004).	Quercetin	11-20	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	139-144
35286330-7	2022	Notably, compared to untreated cells, quercetin supplementation reduces mitochondrial superoxide and hydrogen peroxide production on HBECs cells exposed to different oxidative stress triggers such as 1-2 Naphthoquinone (1-2 NQ) and hydrogen peroxide, suggesting that PON2 might play a protective role ameliorating oxidative injury on human airway epithelium.	Quercetin	38-47	paraoxonase 2	Homo sapiens	267-271
35286330-9	2022	Treatment with quercetin in vitro increased PON2 protein levels and prevented oxidative stress from different types of stimuli.	Quercetin	15-24	paraoxonase 2	Homo sapiens	44-48
35093322-1	2022	Quercetin, a flavonoid abundantly present in the Mediterranean diet, is considered a vasodilator despite its recognized capability to stimulate vascular CaV1.2 channel current (ICa1.2).	Quercetin	0-9	islet cell autoantigen 1	Rattus norvegicus	177-181
35240016-4	2022	Quercetin and sodium butyrate increased the levels of CLAUDIN-1 and ZO-1 (Zonula occludens-1) in the jejunum.	Quercetin	0-9	claudin 1	Homo sapiens	54-63
35240016-4	2022	Quercetin and sodium butyrate increased the levels of CLAUDIN-1 and ZO-1 (Zonula occludens-1) in the jejunum.	Quercetin	0-9	tight junction protein 1	Homo sapiens	68-72
35240016-4	2022	Quercetin and sodium butyrate increased the levels of CLAUDIN-1 and ZO-1 (Zonula occludens-1) in the jejunum.	Quercetin	0-9	tight junction protein 1	Homo sapiens	74-92
35124182-0	2022	Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96-5p.	Quercetin	88-97	insulin	Homo sapiens	24-31
35369029-10	2022	Quercetin significantly inhibited BCRD-induced neuron pyroptosis via downregulation of PYD and card domain containing (ASC), NLR family pyrin domain containing 3 (NLRP3), and caspase-1, and quercetin could reverse BCRD-caused inhibition of neuron viability.	Quercetin	0-9	steroid sulfatase	Mus musculus	119-122
35369029-10	2022	Quercetin significantly inhibited BCRD-induced neuron pyroptosis via downregulation of PYD and card domain containing (ASC), NLR family pyrin domain containing 3 (NLRP3), and caspase-1, and quercetin could reverse BCRD-caused inhibition of neuron viability.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	125-161
35369029-10	2022	Quercetin significantly inhibited BCRD-induced neuron pyroptosis via downregulation of PYD and card domain containing (ASC), NLR family pyrin domain containing 3 (NLRP3), and caspase-1, and quercetin could reverse BCRD-caused inhibition of neuron viability.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	163-168
35369029-10	2022	Quercetin significantly inhibited BCRD-induced neuron pyroptosis via downregulation of PYD and card domain containing (ASC), NLR family pyrin domain containing 3 (NLRP3), and caspase-1, and quercetin could reverse BCRD-caused inhibition of neuron viability.	Quercetin	0-9	caspase 1	Mus musculus	175-184
35369029-11	2022	Quercetin significantly attenuated the symptom of BCRD in mice, and it could reverse the contents of 5-hydroxytryptamine (5-HT), dopamine (DA), and neutrophil elastase (NE) in mice.	Quercetin	0-9	elastase, neutrophil expressed	Mus musculus	148-167
35369029-12	2022	Moreover, quercetin could promote the immune responses in xenograft mice via upregulation of interleukin- (IL-) 2, interferon-gamma (IFN-gamma), and IL-10.	Quercetin	10-19	interferon gamma	Mus musculus	115-131
35369029-12	2022	Moreover, quercetin could promote the immune responses in xenograft mice via upregulation of interleukin- (IL-) 2, interferon-gamma (IFN-gamma), and IL-10.	Quercetin	10-19	interferon gamma	Mus musculus	133-142
35369029-12	2022	Moreover, quercetin could promote the immune responses in xenograft mice via upregulation of interleukin- (IL-) 2, interferon-gamma (IFN-gamma), and IL-10.	Quercetin	10-19	interleukin 10	Mus musculus	149-154
35122929-0	2022	Quercetin protects human liver cells from o,p"-DDT-induced toxicity by suppressing Nrf2 and NADPH oxidase-regulated ROS production.	Quercetin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
35122929-0	2022	Quercetin protects human liver cells from o,p"-DDT-induced toxicity by suppressing Nrf2 and NADPH oxidase-regulated ROS production.	Quercetin	0-9	dual oxidase 2	Homo sapiens	92-105
35510228-0	2022	Quercetin ameliorates Di (2-ethylhexyl) phthalate-induced nephrotoxicity by inhibiting NF-kappaB signaling pathway.	Quercetin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	87-96
35510228-7	2022	High dose of quercetin significantly decreased the gene expressions of NF-kappaB and TNFalpha, whereas the alternations of Nrf2 and HO-1 gene expressions were not significant in quercetin groups in compared with DEHP group.	Quercetin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	71-80
35510228-7	2022	High dose of quercetin significantly decreased the gene expressions of NF-kappaB and TNFalpha, whereas the alternations of Nrf2 and HO-1 gene expressions were not significant in quercetin groups in compared with DEHP group.	Quercetin	13-22	tumor necrosis factor	Homo sapiens	85-93
35510228-7	2022	High dose of quercetin significantly decreased the gene expressions of NF-kappaB and TNFalpha, whereas the alternations of Nrf2 and HO-1 gene expressions were not significant in quercetin groups in compared with DEHP group.	Quercetin	13-22	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
35510228-7	2022	High dose of quercetin significantly decreased the gene expressions of NF-kappaB and TNFalpha, whereas the alternations of Nrf2 and HO-1 gene expressions were not significant in quercetin groups in compared with DEHP group.	Quercetin	13-22	heme oxygenase 1	Homo sapiens	132-136
35510228-8	2022	These findings suggested that the suppression of DEHP-induced nephrotoxicity via quercetin is correlated, at least in part, with its potential to regulate NF-kappaB signaling pathway.	Quercetin	81-90	nuclear factor kappa B subunit 1	Homo sapiens	155-164
34998178-0	2022	Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition.	Quercetin	47-56	epidermal growth factor receptor	Homo sapiens	99-103
34998178-0	2022	Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition.	Quercetin	47-56	AKT serine/threonine kinase 1	Homo sapiens	113-116
35124182-5	2022	Compare with quercetin/EGCG alone, the quercetin-EGCG combination reduced gluconeogenesis to a greater extent via IRS-1/Akt/FOXO1-mediated down-regulation of downstream PEPCK and G-6-pase.	Quercetin	39-48	forkhead box O1	Homo sapiens	124-129
35124182-5	2022	Compare with quercetin/EGCG alone, the quercetin-EGCG combination reduced gluconeogenesis to a greater extent via IRS-1/Akt/FOXO1-mediated down-regulation of downstream PEPCK and G-6-pase.	Quercetin	39-48	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	169-174
35124182-5	2022	Compare with quercetin/EGCG alone, the quercetin-EGCG combination reduced gluconeogenesis to a greater extent via IRS-1/Akt/FOXO1-mediated down-regulation of downstream PEPCK and G-6-pase.	Quercetin	39-48	glucose-6-phosphatase, catalytic	Mus musculus	179-187
35124182-6	2022	In HepG2 cells, the quercetin (5 muM)-EGCG (5 muM) co-treatment exerted greater suppression on PA-induced changes in glucose and glycogen contents and hexokinase and G-6-pase activities than quercetin/EGCG alone (each 10 muM).	Quercetin	20-29	hexokinase 1	Homo sapiens	151-161
35124182-6	2022	In HepG2 cells, the quercetin (5 muM)-EGCG (5 muM) co-treatment exerted greater suppression on PA-induced changes in glucose and glycogen contents and hexokinase and G-6-pase activities than quercetin/EGCG alone (each 10 muM).	Quercetin	20-29	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	166-174
35124182-7	2022	The quercetin-EGCG co-treatment reduced glucose production through targeting FOXO1 and inhibiting the transcription of gluconeogenic enzymes.	Quercetin	4-13	forkhead box O1	Homo sapiens	77-82
35124182-8	2022	MiR-27a-3p and miR-96-5p regulated directly FOXO1 expression and function, and co-inhibition of miR-27a-3p and miR-96-5p weakened greatly the protective effect of quercetin-EGCG combination.	Quercetin	163-172	microRNA 96	Homo sapiens	15-21
35124182-8	2022	MiR-27a-3p and miR-96-5p regulated directly FOXO1 expression and function, and co-inhibition of miR-27a-3p and miR-96-5p weakened greatly the protective effect of quercetin-EGCG combination.	Quercetin	163-172	forkhead box O1	Homo sapiens	44-49
35124182-8	2022	MiR-27a-3p and miR-96-5p regulated directly FOXO1 expression and function, and co-inhibition of miR-27a-3p and miR-96-5p weakened greatly the protective effect of quercetin-EGCG combination.	Quercetin	163-172	microRNA 96	Homo sapiens	111-117
35124182-9	2022	This is the first report on the contributions of miR-27a-3p and miR-96-5p to the synergistic and protective effect of the quercetin-EGCG co-treatment against PA-induced insulin resistance through inhibiting FOXO1 expression.	Quercetin	122-131	microRNA 96	Homo sapiens	64-70
35124182-9	2022	This is the first report on the contributions of miR-27a-3p and miR-96-5p to the synergistic and protective effect of the quercetin-EGCG co-treatment against PA-induced insulin resistance through inhibiting FOXO1 expression.	Quercetin	122-131	insulin	Homo sapiens	169-176
35124182-9	2022	This is the first report on the contributions of miR-27a-3p and miR-96-5p to the synergistic and protective effect of the quercetin-EGCG co-treatment against PA-induced insulin resistance through inhibiting FOXO1 expression.	Quercetin	122-131	forkhead box O1	Homo sapiens	207-212
35122929-7	2022	However, quercetin treatment significantly antagonized o,p"-DDT-induced cytotoxicity, genotoxicity, and apoptosis as well as effects on ROS, Nrf2, and NADPH oxidase.	Quercetin	9-18	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
35122929-7	2022	However, quercetin treatment significantly antagonized o,p"-DDT-induced cytotoxicity, genotoxicity, and apoptosis as well as effects on ROS, Nrf2, and NADPH oxidase.	Quercetin	9-18	dual oxidase 2	Homo sapiens	151-164
35122929-8	2022	Taken together, these findings suggested quercetin could alleviate o,p"-DDT-induced toxicity in HL-7702 cells via inhibiting ROS production, which is modulated by down-regulating nuclear Nrf2 levels and NADPH oxidase expression.	Quercetin	41-50	NFE2 like bZIP transcription factor 2	Homo sapiens	187-191
35122929-8	2022	Taken together, these findings suggested quercetin could alleviate o,p"-DDT-induced toxicity in HL-7702 cells via inhibiting ROS production, which is modulated by down-regulating nuclear Nrf2 levels and NADPH oxidase expression.	Quercetin	41-50	dual oxidase 2	Homo sapiens	203-216
35124182-0	2022	Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96-5p.	Quercetin	88-97	insulin receptor substrate 1	Homo sapiens	51-56
35124182-0	2022	Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96-5p.	Quercetin	88-97	AKT serine/threonine kinase 1	Homo sapiens	57-60
35124182-0	2022	Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96-5p.	Quercetin	88-97	forkhead box O1	Homo sapiens	61-66
35124182-3	2022	Quercetin, EGCG or their combination attenuated insulin resistance and decreased hepatic gluconeogenesis in high-fat-high-fructose diet (HFFD)-fed C57BL/6 mice and in palmitic acid (PA)-treated HepG2 cells.	Quercetin	0-9	insulin	Homo sapiens	48-55
35124182-5	2022	Compare with quercetin/EGCG alone, the quercetin-EGCG combination reduced gluconeogenesis to a greater extent via IRS-1/Akt/FOXO1-mediated down-regulation of downstream PEPCK and G-6-pase.	Quercetin	13-22	insulin receptor substrate 1	Homo sapiens	114-119
35124182-5	2022	Compare with quercetin/EGCG alone, the quercetin-EGCG combination reduced gluconeogenesis to a greater extent via IRS-1/Akt/FOXO1-mediated down-regulation of downstream PEPCK and G-6-pase.	Quercetin	13-22	AKT serine/threonine kinase 1	Homo sapiens	120-123
35124182-5	2022	Compare with quercetin/EGCG alone, the quercetin-EGCG combination reduced gluconeogenesis to a greater extent via IRS-1/Akt/FOXO1-mediated down-regulation of downstream PEPCK and G-6-pase.	Quercetin	13-22	forkhead box O1	Homo sapiens	124-129
35124182-5	2022	Compare with quercetin/EGCG alone, the quercetin-EGCG combination reduced gluconeogenesis to a greater extent via IRS-1/Akt/FOXO1-mediated down-regulation of downstream PEPCK and G-6-pase.	Quercetin	13-22	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	169-174
35124182-5	2022	Compare with quercetin/EGCG alone, the quercetin-EGCG combination reduced gluconeogenesis to a greater extent via IRS-1/Akt/FOXO1-mediated down-regulation of downstream PEPCK and G-6-pase.	Quercetin	39-48	insulin receptor substrate 1	Homo sapiens	114-119
35124182-5	2022	Compare with quercetin/EGCG alone, the quercetin-EGCG combination reduced gluconeogenesis to a greater extent via IRS-1/Akt/FOXO1-mediated down-regulation of downstream PEPCK and G-6-pase.	Quercetin	39-48	AKT serine/threonine kinase 1	Homo sapiens	120-123
35227068-10	2022	Molecular docking verification showed that quercetin had the best binding with the core target protein HSP90AA1, and HSP90AA1 was the target protein with the best binding activity for the key chemical components in Xiexin capsules.	Quercetin	43-52	heat shock protein 90 alpha family class A member 1	Homo sapiens	103-111
35187882-0	2022	Quercetin ameliorates glutamate toxicity-induced neuronal cell death by controlling calcium-binding protein parvalbumin.	Quercetin	0-9	parvalbumin	Homo sapiens	108-119
35187882-11	2022	Glutamate increased caspase-3 expression, and quercetin attenuated this increase in both parvalbumin siRNA transfected and non-transfected cells.	Quercetin	46-55	parvalbumin	Homo sapiens	89-100
35187882-13	2022	Moreover, glutamate decreased bcl-2 and increased bax expressions, while quercetin alleviated these changes.	Quercetin	73-82	BCL2 associated X, apoptosis regulator	Homo sapiens	50-53
35187882-14	2022	The alleviative effect of quercetin in bcl-2 family protein expression was more remarkable in non-transfected cells.	Quercetin	26-35	BCL2 apoptosis regulator	Homo sapiens	39-44
35187882-15	2022	CONCLUSIONS: These results demonstrate that parvalbumin contributes to the maintainace of intracellular calcium concentration and the prevention of apoptosis, and quercetin modulates parvalbumin expression in glutamate-exposed cells.	Quercetin	163-172	parvalbumin	Homo sapiens	183-194
35187882-16	2022	Thus, these findings suggest that quercetin performs neuroprotective function against glutamate toxicity by regulating parvalbumin expression.	Quercetin	34-43	parvalbumin	Homo sapiens	119-130
35227068-10	2022	Molecular docking verification showed that quercetin had the best binding with the core target protein HSP90AA1, and HSP90AA1 was the target protein with the best binding activity for the key chemical components in Xiexin capsules.	Quercetin	43-52	heat shock protein 90 alpha family class A member 1	Homo sapiens	117-125
35295707-8	2022	Moreover, the study examined the effect of quercetin on astrocytes activation and neuroinflammation, and the results indicated that it significantly attenuated the activation of astrocytes and reduced the levels of IL-1beta, TNFalpha but not IL-6.	Quercetin	43-52	interleukin 1 alpha	Mus musculus	215-223
35295707-8	2022	Moreover, the study examined the effect of quercetin on astrocytes activation and neuroinflammation, and the results indicated that it significantly attenuated the activation of astrocytes and reduced the levels of IL-1beta, TNFalpha but not IL-6.	Quercetin	43-52	tumor necrosis factor	Mus musculus	225-233
35295707-8	2022	Moreover, the study examined the effect of quercetin on astrocytes activation and neuroinflammation, and the results indicated that it significantly attenuated the activation of astrocytes and reduced the levels of IL-1beta, TNFalpha but not IL-6.	Quercetin	43-52	interleukin 6	Mus musculus	242-246
35194046-0	2022	Quercetin induces pannexin 1 expression via an alternative transcript with a translationally active 5" leader in rhabdomyosarcoma.	Quercetin	0-9	pannexin 1	Homo sapiens	18-28
35284458-7	2022	The results clearly showed that two abundant constituents in AGE (dihydromyricetin and iso-dihydromyricetin) were moderate hPL inhibitors, while myricetin and quercetin were strong hPL inhibitors (half-maximal inhibitory concentration (IC 50) values were around 1.5 muM).	Quercetin	159-168	galectin 1	Homo sapiens	181-184
35284458-8	2022	Inhibition kinetic analyses demonstrated that myricetin and quercetin potently inhibited hPL-catalyzed near-infrared fluorogenic substrate of human pancreatic lipase (DDAO-ol) hydrolysis in a non-competitive inhibition manner, with K i values of 2.04 and 2.33 muM, respectively.	Quercetin	60-69	galectin 1	Homo sapiens	89-92
35284458-8	2022	Inhibition kinetic analyses demonstrated that myricetin and quercetin potently inhibited hPL-catalyzed near-infrared fluorogenic substrate of human pancreatic lipase (DDAO-ol) hydrolysis in a non-competitive inhibition manner, with K i values of 2.04 and 2.33 muM, respectively.	Quercetin	60-69	pancreatic lipase	Homo sapiens	148-165
35284458-9	2022	Molecular dynamics simulations indicated that myricetin and quercetin could stably bind on an allosteric site of hPL.	Quercetin	60-69	galectin 1	Homo sapiens	113-116
35156972-6	2022	The lower limit of quantification (LLOQ) of quercetin and piperine was obtained as 0.1 ng mL-1 in rat plasma, along with negligible matrix effect and acceptable stability.	Quercetin	44-53	L1 cell adhesion molecule	Mus musculus	90-94
35273602-3	2022	Our results indicated that phenolic COX-2 inhibitors such as quercetin, resveratrol, epigallocatechin gallate, anacardic acid, and garcinol enhanced HDP gene expression in chicken HTC macrophage cell line and peripheral blood mononuclear cells (PBMCs).	Quercetin	61-70	prostaglandin-endoperoxide synthase 2	Gallus gallus	36-41
35273602-5	2022	Additionally, quercetin and butyrate synergistically promoted the expressions of mucin-2 and claudin-1, two major genes involved in barrier function, while suppressing lipopolysaccharide-triggered interleukin-1beta expression in HTC macrophages.	Quercetin	14-23	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	81-88
35273602-5	2022	Additionally, quercetin and butyrate synergistically promoted the expressions of mucin-2 and claudin-1, two major genes involved in barrier function, while suppressing lipopolysaccharide-triggered interleukin-1beta expression in HTC macrophages.	Quercetin	14-23	claudin 1	Gallus gallus	93-102
35273602-5	2022	Additionally, quercetin and butyrate synergistically promoted the expressions of mucin-2 and claudin-1, two major genes involved in barrier function, while suppressing lipopolysaccharide-triggered interleukin-1beta expression in HTC macrophages.	Quercetin	14-23	interleukin 1, beta	Gallus gallus	197-214
35273602-6	2022	Mechanistically, we revealed that NF-kappaB, p38 mitogen-activated protein kinase, and cyclic adenosine monophosphate signaling pathways were all involved in the avian beta-defensin 9 gene induction, but histone H4 was not hyperacetylated in response to a combination of butyrate and quercetin.	Quercetin	284-293	avian beta-defensin 9	Gallus gallus	168-183
35193490-0	2022	Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats.	Quercetin	0-9	adenosine deaminase	Rattus norvegicus	55-74
35193490-3	2022	In this study, we evaluated the in-silico, and in vivo inhibitory effect of quercetin isolated from Egyptian Fenugreek on ADA enzyme activity.	Quercetin	76-85	adenosine deaminase	Rattus norvegicus	122-125
35193490-6	2022	The results showed that the inhibition constant of quercetin on joint ADA by docking and in-vitro was 61.9 and 55.5 mM, respectively.	Quercetin	51-60	adenosine deaminase	Rattus norvegicus	70-73
35193490-7	2022	Therefore, quercetin exhibits anti-inflammatory effect in a rat RA model as evidenced by reducing the specific activity of ADA in joint tissues, lower jaw volume, enhance body weight, downregulate ADA gene expression, reduce levels of RA cytokines interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, also, rheumatoid factor, C-reactive protein, and anti-cyclic citrullinated peptide RA biomarker levels.	Quercetin	11-20	adenosine deaminase	Rattus norvegicus	123-126
35193490-7	2022	Therefore, quercetin exhibits anti-inflammatory effect in a rat RA model as evidenced by reducing the specific activity of ADA in joint tissues, lower jaw volume, enhance body weight, downregulate ADA gene expression, reduce levels of RA cytokines interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, also, rheumatoid factor, C-reactive protein, and anti-cyclic citrullinated peptide RA biomarker levels.	Quercetin	11-20	adenosine deaminase	Rattus norvegicus	197-200
35193490-7	2022	Therefore, quercetin exhibits anti-inflammatory effect in a rat RA model as evidenced by reducing the specific activity of ADA in joint tissues, lower jaw volume, enhance body weight, downregulate ADA gene expression, reduce levels of RA cytokines interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, also, rheumatoid factor, C-reactive protein, and anti-cyclic citrullinated peptide RA biomarker levels.	Quercetin	11-20	interleukin 1 beta	Rattus norvegicus	248-265
35193490-7	2022	Therefore, quercetin exhibits anti-inflammatory effect in a rat RA model as evidenced by reducing the specific activity of ADA in joint tissues, lower jaw volume, enhance body weight, downregulate ADA gene expression, reduce levels of RA cytokines interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, also, rheumatoid factor, C-reactive protein, and anti-cyclic citrullinated peptide RA biomarker levels.	Quercetin	11-20	interleukin 6	Rattus norvegicus	267-280
35193490-7	2022	Therefore, quercetin exhibits anti-inflammatory effect in a rat RA model as evidenced by reducing the specific activity of ADA in joint tissues, lower jaw volume, enhance body weight, downregulate ADA gene expression, reduce levels of RA cytokines interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, also, rheumatoid factor, C-reactive protein, and anti-cyclic citrullinated peptide RA biomarker levels.	Quercetin	11-20	tumor necrosis factor	Rattus norvegicus	282-309
35193490-7	2022	Therefore, quercetin exhibits anti-inflammatory effect in a rat RA model as evidenced by reducing the specific activity of ADA in joint tissues, lower jaw volume, enhance body weight, downregulate ADA gene expression, reduce levels of RA cytokines interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, also, rheumatoid factor, C-reactive protein, and anti-cyclic citrullinated peptide RA biomarker levels.	Quercetin	11-20	C-reactive protein	Rattus norvegicus	336-354
35193490-8	2022	These findings demonstrate that the purified quercetin has a promising anti-inflammatory effect against RA disease through its inhibitory effects on the ADA enzyme.	Quercetin	45-54	adenosine deaminase	Rattus norvegicus	153-156
35194046-6	2022	We uncover that quercetin, a natural plant flavonoid, increases PANX1 protein levels in RMS by inducing re-expression of a 5" leader-containing PANX1 transcript variant that is efficiently translated.	Quercetin	16-25	pannexin 1	Homo sapiens	64-69
35194046-6	2022	We uncover that quercetin, a natural plant flavonoid, increases PANX1 protein levels in RMS by inducing re-expression of a 5" leader-containing PANX1 transcript variant that is efficiently translated.	Quercetin	16-25	pannexin 1	Homo sapiens	144-149
35194046-8	2022	Mechanistically, abolishing ETV4 transcription factor binding sites in the PANX1 promoter significantly reduced the luciferase reporter activities and PANX1 5" UTR levels, and both quercetin treatment in RMS cells and induction of differentiation in HSMM enriched the binding of ETV4 to its consensus element in the PANX1 promoter.	Quercetin	181-190	ETS variant transcription factor 4	Homo sapiens	28-32
35194046-9	2022	Notably, quercetin treatment promoted RMS differentiation in a PANX1-dependent manner.	Quercetin	9-18	pannexin 1	Homo sapiens	63-68
35194046-11	2022	Collectively, our results demonstrate the tumor-suppressive effects of quercetin in RMS and present a hitherto undescribed mechanism of PANX1 regulation via ETV4-mediated transcription of a translationally functional 5" leader-containing PANX1 mRNA.	Quercetin	71-80	pannexin 1	Homo sapiens	136-141
35194046-11	2022	Collectively, our results demonstrate the tumor-suppressive effects of quercetin in RMS and present a hitherto undescribed mechanism of PANX1 regulation via ETV4-mediated transcription of a translationally functional 5" leader-containing PANX1 mRNA.	Quercetin	71-80	ETS variant transcription factor 4	Homo sapiens	157-161
35194046-11	2022	Collectively, our results demonstrate the tumor-suppressive effects of quercetin in RMS and present a hitherto undescribed mechanism of PANX1 regulation via ETV4-mediated transcription of a translationally functional 5" leader-containing PANX1 mRNA.	Quercetin	71-80	pannexin 1	Homo sapiens	238-243
35305353-10	2022	Meanwhile tanshinone IIA, resveratrol, and silibinin inhibited ATM and/or DNA-PK activation and decreased viral proliferation, while rutin and quercetin inhibited ATR activation and promoted viral production.	Quercetin	143-152	ATR serine/threonine kinase	Homo sapiens	163-166
35499028-0	2022	Glycated alpha-lactalbumin based micelles for quercetin delivery: Physicochemical stability and fate of simulated digestion.	Quercetin	46-55	lactalbumin alpha	Homo sapiens	9-26
35499028-2	2022	In this study, the alpha-lactalbumin (ALA)-dextran conjugates synthesized by Maillard reaction were fabricated to load and protect quercetin.	Quercetin	131-140	lactalbumin alpha	Homo sapiens	19-36
35186104-15	2022	Conclusions: Danlong Dingchuan Decoction may act on key targets (such as IL-6, TNF, CXCL8, VEGFA, and MAPK3) with key active ingredients (such as quercetin, xanthine, lysine, kaempferol, and ss-sitosterol) to reduce the expression levels of IL-4, IL-6, IL-8, and other Th2 cytokines.	Quercetin	146-155	tumor necrosis factor	Mus musculus	79-82
35065992-0	2022	Development of quercetin-loaded PVCL-PVA-PEG micelles and application in inhibiting tumor angiogenesis through the PI3K/Akt/VEGF pathway.	Quercetin	15-24	vascular endothelial growth factor A	Gallus gallus	124-128
35237157-7	2022	Molecular docking analysis of the compounds to inflammation-associated targets revealed good binding abilities of quercetin, kaempferol, licochalcone A and liquiritin to NF-kappaB p65 and of quercetin and kaempferol to Akt1 or Caspase-3.	Quercetin	114-123	RELA proto-oncogene, NF-kB subunit	Homo sapiens	170-183
35237157-7	2022	Molecular docking analysis of the compounds to inflammation-associated targets revealed good binding abilities of quercetin, kaempferol, licochalcone A and liquiritin to NF-kappaB p65 and of quercetin and kaempferol to Akt1 or Caspase-3.	Quercetin	114-123	AKT serine/threonine kinase 1	Homo sapiens	219-223
35237157-7	2022	Molecular docking analysis of the compounds to inflammation-associated targets revealed good binding abilities of quercetin, kaempferol, licochalcone A and liquiritin to NF-kappaB p65 and of quercetin and kaempferol to Akt1 or Caspase-3.	Quercetin	114-123	caspase 3	Homo sapiens	227-236
35149956-9	2022	PERK, CHOP, and the concomitant responses of quercetin in restoring the ER homeostasis in cellular organelles like mitochondria and ER, against Cu-induced toxic insults by modulating autophagic pathways.	Quercetin	45-54	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	0-4
35149956-9	2022	PERK, CHOP, and the concomitant responses of quercetin in restoring the ER homeostasis in cellular organelles like mitochondria and ER, against Cu-induced toxic insults by modulating autophagic pathways.	Quercetin	45-54	DNA damage inducible transcript 3	Homo sapiens	6-10
35223693-13	2022	TLR4 protein expressions were increased in the HINS group when compared to control group, and decreased in the group of quercetin.	Quercetin	120-129	toll-like receptor 4	Rattus norvegicus	0-4
35223693-14	2022	The protein level of p-NF-kappaB p65 was significantly lower in the quercetin group compared to the HINS group.	Quercetin	68-77	synaptotagmin 1	Rattus norvegicus	33-36
35223693-16	2022	Quercetin could downregulate inflammatory response through TLR4/ NF-kappaB pathway, thereby attenuating HINS-induced anxiety, hippocampal memory impairment, and cognitive impairment in later life following HINS.	Quercetin	0-9	toll-like receptor 4	Rattus norvegicus	59-63
35214154-1	2022	Lacking nano-systems for precisely codelivering the chemotherapeutics paclitaxel (PTX) and the natural P-glycoprotein (P-gp) inhibitor, quercetin (QU), into cancer cells and controlling their intracellular release extremely decreased the anticancer effects in multidrug resistant (MDR) tumors.	Quercetin	136-145	phosphoglycolate phosphatase	Mus musculus	103-117
35214154-1	2022	Lacking nano-systems for precisely codelivering the chemotherapeutics paclitaxel (PTX) and the natural P-glycoprotein (P-gp) inhibitor, quercetin (QU), into cancer cells and controlling their intracellular release extremely decreased the anticancer effects in multidrug resistant (MDR) tumors.	Quercetin	136-145	phosphoglycolate phosphatase	Mus musculus	119-123
35237157-8	2022	Moreover, molecular dynamics (MD) simulation for binding of quercetin or kaempferol to NF-kappaB p65 revealed dynamic properties of high stability, high flexibility and lowbinding free energy.	Quercetin	60-69	RELA proto-oncogene, NF-kB subunit	Homo sapiens	87-100
35209054-0	2022	Interaction Characterization of a Tyrosine Kinase Inhibitor Erlotinib with a Model Transport Protein in the Presence of Quercetin: A Drug-Protein and Drug-Drug Interaction Investigation Using Multi-Spectroscopic and Computational Approaches.	Quercetin	120-129	TXK tyrosine kinase	Homo sapiens	34-49
35209054-1	2022	The interaction between erlotinib (ERL) and bovine serum albumin (BSA) was studied in the presence of quercetin (QUR), a flavonoid with antioxidant properties.	Quercetin	102-111	albumin	Homo sapiens	51-64
35204240-5	2022	Histopathological and immunohistochemical analyses showed that quercetin decreases the size of preneoplastic lesions, glycogen and collagen accumulation, the expression of cancer stem cells and myofibroblasts markers, and that of the transporter ATP binding cassette subfamily C member 3 (ABCC3), a marker of HCC progression and multi-drug resistance.	Quercetin	63-72	ATP binding cassette subfamily C member 3	Rattus norvegicus	289-294
35204240-6	2022	Our results strongly suggest that quercetin has the capability to reduce key components of TME, as well as the expression of ABCC3.	Quercetin	34-43	ATP binding cassette subfamily C member 3	Rattus norvegicus	125-130
35186104-11	2022	Enrichment analysis showed that quercetin, xanthine, lysine, kaempferol, ss-sitosterol, and four other active compounds were the main components of Danlong Dingchuan Decoction; IL-6, TNF, CXCL8, VEGFA, MAPK3, IL-10, PTGS2, IL-1beta, IL-4, and TLR4 were the potential targets for therapy.	Quercetin	32-41	interleukin 6	Mus musculus	177-181
35186104-13	2022	Molecular docking analysis showed that quercetin combined well with TNF, CXCL8, and TLR4.	Quercetin	39-48	tumor necrosis factor	Mus musculus	68-71
35186104-13	2022	Molecular docking analysis showed that quercetin combined well with TNF, CXCL8, and TLR4.	Quercetin	39-48	toll-like receptor 4	Mus musculus	84-88
35105256-8	2022	The quercetin treated diabetic group exhibited increased levels of catalase, glutathione peroxidase, superoxide dismutase and total thiols compared to the diabetic group.	Quercetin	4-13	catalase	Rattus norvegicus	67-75
35135448-9	2022	Molecular docking and dynamics simulations were performed to study the interaction between selected target genes (Chemokine ligand 2 (CCL2) and matrix metalloproteinase 1 (MMP1)) and active ingredients (quercetin and wogonin) of Ermiao San.	Quercetin	203-212	C-C motif chemokine ligand 2	Homo sapiens	134-138
35135448-9	2022	Molecular docking and dynamics simulations were performed to study the interaction between selected target genes (Chemokine ligand 2 (CCL2) and matrix metalloproteinase 1 (MMP1)) and active ingredients (quercetin and wogonin) of Ermiao San.	Quercetin	203-212	matrix metallopeptidase 1	Homo sapiens	144-170
35135448-9	2022	Molecular docking and dynamics simulations were performed to study the interaction between selected target genes (Chemokine ligand 2 (CCL2) and matrix metalloproteinase 1 (MMP1)) and active ingredients (quercetin and wogonin) of Ermiao San.	Quercetin	203-212	matrix metallopeptidase 1	Homo sapiens	172-176
35135448-11	2022	CCL2 and MMP1 were identified and verified to be the targets of both quercetin and wogonin, the two active ingredients of Ermiao San, by molecular docking and molecular dynamics.	Quercetin	69-78	C-C motif chemokine ligand 2	Homo sapiens	0-4
35135448-11	2022	CCL2 and MMP1 were identified and verified to be the targets of both quercetin and wogonin, the two active ingredients of Ermiao San, by molecular docking and molecular dynamics.	Quercetin	69-78	matrix metallopeptidase 1	Homo sapiens	9-13
35130279-8	2022	In addition, good molecular docking scores were highlighted between five promising bioactive compounds (ellagic acid, quercetin, kaempferol, galangin, coptisine) and five core targets (PTGS2, STAT3, VEGFA, MAPK3, TNF).	Quercetin	118-127	vascular endothelial growth factor A	Homo sapiens	199-204
35130279-8	2022	In addition, good molecular docking scores were highlighted between five promising bioactive compounds (ellagic acid, quercetin, kaempferol, galangin, coptisine) and five core targets (PTGS2, STAT3, VEGFA, MAPK3, TNF).	Quercetin	118-127	mitogen-activated protein kinase 3	Homo sapiens	206-211
35130279-8	2022	In addition, good molecular docking scores were highlighted between five promising bioactive compounds (ellagic acid, quercetin, kaempferol, galangin, coptisine) and five core targets (PTGS2, STAT3, VEGFA, MAPK3, TNF).	Quercetin	118-127	tumor necrosis factor	Homo sapiens	213-216
35120520-11	2022	The docking scores toward proteins 3ODU of CXCR4 and 6K3F of CXCR7 were - 7.71 and - 7.17 for curcumin, - 5.97 and - 6.03 for quercetin, - 5.68 and - 5.49 for trans-resveratrol, and - 4.88 and - 4.70 for (1 s,4 s)-eucalyptol respectively indicating that all compounds, except quercetin, have more interactions with CXCR4 than with CXCR7.	Quercetin	126-135	C-X-C motif chemokine receptor 4	Homo sapiens	43-48
35120520-11	2022	The docking scores toward proteins 3ODU of CXCR4 and 6K3F of CXCR7 were - 7.71 and - 7.17 for curcumin, - 5.97 and - 6.03 for quercetin, - 5.68 and - 5.49 for trans-resveratrol, and - 4.88 and - 4.70 for (1 s,4 s)-eucalyptol respectively indicating that all compounds, except quercetin, have more interactions with CXCR4 than with CXCR7.	Quercetin	126-135	atypical chemokine receptor 3	Homo sapiens	61-66
35120520-11	2022	The docking scores toward proteins 3ODU of CXCR4 and 6K3F of CXCR7 were - 7.71 and - 7.17 for curcumin, - 5.97 and - 6.03 for quercetin, - 5.68 and - 5.49 for trans-resveratrol, and - 4.88 and - 4.70 for (1 s,4 s)-eucalyptol respectively indicating that all compounds, except quercetin, have more interactions with CXCR4 than with CXCR7.	Quercetin	276-285	C-X-C motif chemokine receptor 4	Homo sapiens	43-48
35120520-11	2022	The docking scores toward proteins 3ODU of CXCR4 and 6K3F of CXCR7 were - 7.71 and - 7.17 for curcumin, - 5.97 and - 6.03 for quercetin, - 5.68 and - 5.49 for trans-resveratrol, and - 4.88 and - 4.70 for (1 s,4 s)-eucalyptol respectively indicating that all compounds, except quercetin, have more interactions with CXCR4 than with CXCR7.	Quercetin	276-285	atypical chemokine receptor 3	Homo sapiens	61-66
35120520-16	2022	CONCLUSIONS: Curcumin showed the top binding interaction against active sites of CXCR4 and CXCR7 receptors, with the best safety profile, followed by quercetin, resveratrol, and eucalyptol.	Quercetin	150-159	C-X-C motif chemokine receptor 4	Homo sapiens	81-86
35120520-16	2022	CONCLUSIONS: Curcumin showed the top binding interaction against active sites of CXCR4 and CXCR7 receptors, with the best safety profile, followed by quercetin, resveratrol, and eucalyptol.	Quercetin	150-159	atypical chemokine receptor 3	Homo sapiens	91-96
35277012-3	2022	Nevertheless, in vitro and in vivo studies and clinical trials with humans show that the SIRT1-activating compounds derived from natural sources, such as polyphenols found in fruits, vegetables, and plants, including resveratrol, quercetin, and isoflavones, can prevent disease and be part of treatments for a wide variety of diseases.	Quercetin	230-239	sirtuin 1	Homo sapiens	89-94
35237152-9	2022	This demonstrated that quercetin, luteolin, hyndarin, and beta-sitosterol had good binding to eight key proteins, and Akt1 was the target protein with the best binding activity, suggesting that Akt1 could be the essential mediator responsible for signaling transduction after QZZTD administration.	Quercetin	23-32	AKT serine/threonine kinase 1	Rattus norvegicus	118-122
35237152-11	2022	In conclusion, our study suggested four potential key active components, including quercetin, were identified in QZZTD, which could interact with Akt1 and modulate the activation of the PI3K-Akt pathway.	Quercetin	83-92	AKT serine/threonine kinase 1	Rattus norvegicus	146-150
35237152-11	2022	In conclusion, our study suggested four potential key active components, including quercetin, were identified in QZZTD, which could interact with Akt1 and modulate the activation of the PI3K-Akt pathway.	Quercetin	83-92	AKT serine/threonine kinase 1	Rattus norvegicus	191-194
35105256-11	2022	The expression of proliferating cell nuclear antigen) (PCNA) was greater in the quercetin treated diabetic group on day 7 compared to healthy control and diabetic groups.	Quercetin	80-89	proliferating cell nuclear antigen	Rattus norvegicus	18-53
35105256-11	2022	The expression of proliferating cell nuclear antigen) (PCNA) was greater in the quercetin treated diabetic group on day 7 compared to healthy control and diabetic groups.	Quercetin	80-89	proliferating cell nuclear antigen	Rattus norvegicus	55-59
34984688-10	2022	Pretreatment with quercetin was effective at attenuating histopathologic changes in hepatic and renal tissues by regulating the immunoexpression of caspase-3 and Bcl-2 to return them to more normal values.	Quercetin	18-27	caspase 3	Rattus norvegicus	148-157
35051762-10	2022	The glutathione, catalase, and glutathione peroxidase activities of the kidney, liver, and heart tissue were increased by quercetin supplementation.	Quercetin	122-131	catalase	Coturnix japonica	17-25
35051762-12	2022	The expression of caspase-3 and caspase-9 were significantly decreased by quercetin supplementation.	Quercetin	74-83	caspase-3	Coturnix japonica	18-27
35051762-12	2022	The expression of caspase-3 and caspase-9 were significantly decreased by quercetin supplementation.	Quercetin	74-83	caspase-9	Coturnix japonica	32-41
35280377-10	2022	Molecular docking confirmed that luteolin, coumarin, and quercetin could bind to the key target proteins (i.e., STAT3, PIK3R1, and MAPK1).	Quercetin	57-66	signal transducer and activator of transcription 3	Homo sapiens	112-117
35280377-10	2022	Molecular docking confirmed that luteolin, coumarin, and quercetin could bind to the key target proteins (i.e., STAT3, PIK3R1, and MAPK1).	Quercetin	57-66	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	119-125
35280377-10	2022	Molecular docking confirmed that luteolin, coumarin, and quercetin could bind to the key target proteins (i.e., STAT3, PIK3R1, and MAPK1).	Quercetin	57-66	mitogen-activated protein kinase 1	Homo sapiens	131-136
35048514-0	2022	Retraction statement: Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling.	Quercetin	22-31	signal transducer and activator of transcription 3	Homo sapiens	132-137
34984688-10	2022	Pretreatment with quercetin was effective at attenuating histopathologic changes in hepatic and renal tissues by regulating the immunoexpression of caspase-3 and Bcl-2 to return them to more normal values.	Quercetin	18-27	BCL2, apoptosis regulator	Rattus norvegicus	162-167
35155877-0	2022	Perillyl alcohol and quercetin modulate the expression of non-coding RNAs MIAT, H19, miR-29a, and miR-33a in pulmonary artery hypertension in rats.	Quercetin	21-30	myocardial infarction associated transcript	Rattus norvegicus	74-78
35140796-14	2022	Molecular docking simulation indicated that potential glioma-related targets-MAPK1 and HSP90AA1 were bounded more firmly with epigallocatechin-3-gallate (EGCG) than with quercetin.	Quercetin	170-179	mitogen-activated protein kinase 1	Homo sapiens	77-82
35140796-14	2022	Molecular docking simulation indicated that potential glioma-related targets-MAPK1 and HSP90AA1 were bounded more firmly with epigallocatechin-3-gallate (EGCG) than with quercetin.	Quercetin	170-179	heat shock protein 90 alpha family class A member 1	Homo sapiens	87-95
34994822-0	2022	Anti-proliferative effects of the combination of Sulfamethoxazole and Quercetin via caspase3 and NFkB gene regulation: an in vitro and in vivo study.	Quercetin	70-79	caspase 3	Homo sapiens	84-92
35155877-0	2022	Perillyl alcohol and quercetin modulate the expression of non-coding RNAs MIAT, H19, miR-29a, and miR-33a in pulmonary artery hypertension in rats.	Quercetin	21-30	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	80-83
35155877-0	2022	Perillyl alcohol and quercetin modulate the expression of non-coding RNAs MIAT, H19, miR-29a, and miR-33a in pulmonary artery hypertension in rats.	Quercetin	21-30	microRNA 29a	Rattus norvegicus	85-92
35155962-9	2022	The experiment validated quercetin might suppress chondrocyte apoptosis mediated by IL-1beta and reduce SELE, MMP2, and COL1 expression.	Quercetin	25-34	interleukin 1 alpha	Rattus norvegicus	84-92
35155962-9	2022	The experiment validated quercetin might suppress chondrocyte apoptosis mediated by IL-1beta and reduce SELE, MMP2, and COL1 expression.	Quercetin	25-34	selectin E	Rattus norvegicus	104-108
35060921-4	2022	The composition containing vitamin C, N-acetylcysteine, resveratrol, theaflavin, curcumin, quercetin, naringenin, baicalin, and broccoli extract demonstrated a highest efficacy by inhibiting the receptor-binding domain (RBD) binding of SARS-CoV-2 to its cellular ACE2 receptor by 90%.	Quercetin	91-100	angiotensin converting enzyme 2	Homo sapiens	263-267
35155962-9	2022	The experiment validated quercetin might suppress chondrocyte apoptosis mediated by IL-1beta and reduce SELE, MMP2, and COL1 expression.	Quercetin	25-34	matrix metallopeptidase 2	Rattus norvegicus	110-114
35155962-10	2022	Via the AGE-RAGE signaling pathway in diabetic complications, quercetin could aim at SELE, MMP2, and COL1 and exert antagonistic effects against OA.	Quercetin	62-71	renin binding protein	Rattus norvegicus	8-11
35155962-10	2022	Via the AGE-RAGE signaling pathway in diabetic complications, quercetin could aim at SELE, MMP2, and COL1 and exert antagonistic effects against OA.	Quercetin	62-71	advanced glycosylation end product-specific receptor	Rattus norvegicus	12-16
35155962-10	2022	Via the AGE-RAGE signaling pathway in diabetic complications, quercetin could aim at SELE, MMP2, and COL1 and exert antagonistic effects against OA.	Quercetin	62-71	selectin E	Rattus norvegicus	85-89
35155962-10	2022	Via the AGE-RAGE signaling pathway in diabetic complications, quercetin could aim at SELE, MMP2, and COL1 and exert antagonistic effects against OA.	Quercetin	62-71	matrix metallopeptidase 2	Rattus norvegicus	91-95
35155643-6	2021	In addition, 0.06% quercetin significantly increased the content of serum calcium-binding protein (CB), estradiol (E2), osteocalcin (OC), alkaline phosphatase (ALP), and calcitonin (CT) (P < 0.05); 0.04% quercetin significantly increased 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) (P < 0.05) content in serum of broilers.	Quercetin	19-28	centrin 1	Homo sapiens	74-97
35155643-6	2021	In addition, 0.06% quercetin significantly increased the content of serum calcium-binding protein (CB), estradiol (E2), osteocalcin (OC), alkaline phosphatase (ALP), and calcitonin (CT) (P < 0.05); 0.04% quercetin significantly increased 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) (P < 0.05) content in serum of broilers.	Quercetin	19-28	bone gamma-carboxyglutamate protein	Homo sapiens	120-131
35155643-6	2021	In addition, 0.06% quercetin significantly increased the content of serum calcium-binding protein (CB), estradiol (E2), osteocalcin (OC), alkaline phosphatase (ALP), and calcitonin (CT) (P < 0.05); 0.04% quercetin significantly increased 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) (P < 0.05) content in serum of broilers.	Quercetin	19-28	bone gamma-carboxyglutamate protein	Homo sapiens	133-135
35155643-6	2021	In addition, 0.06% quercetin significantly increased the content of serum calcium-binding protein (CB), estradiol (E2), osteocalcin (OC), alkaline phosphatase (ALP), and calcitonin (CT) (P < 0.05); 0.04% quercetin significantly increased 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) (P < 0.05) content in serum of broilers.	Quercetin	19-28	alkaline phosphatase, placental	Homo sapiens	138-158
35155643-6	2021	In addition, 0.06% quercetin significantly increased the content of serum calcium-binding protein (CB), estradiol (E2), osteocalcin (OC), alkaline phosphatase (ALP), and calcitonin (CT) (P < 0.05); 0.04% quercetin significantly increased 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) (P < 0.05) content in serum of broilers.	Quercetin	19-28	alkaline phosphatase, placental	Homo sapiens	160-163
35155643-6	2021	In addition, 0.06% quercetin significantly increased the content of serum calcium-binding protein (CB), estradiol (E2), osteocalcin (OC), alkaline phosphatase (ALP), and calcitonin (CT) (P < 0.05); 0.04% quercetin significantly increased 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) (P < 0.05) content in serum of broilers.	Quercetin	19-28	calcitonin related polypeptide alpha	Homo sapiens	170-180
35155643-7	2021	The content of serum parathyroid (PTH) was significantly decreased by 0.02 and 0.06% quercetin (P < 0.05) in broilers.	Quercetin	85-94	parathyroid hormone	Homo sapiens	34-37
35070983-13	2021	The KEGG pathway analysis revealed that quercetin and cisplatin may affect cervical cancer through platinum drug resistance and the p53 and HIF-1 pathways.	Quercetin	40-49	tumor protein p53	Homo sapiens	132-135
35199059-4	2022	We study a lead NP consisting of quercetin and find that the NP after intravenous administration preferentially binds to VEGFR2, which is overexpressed in tumor vasculature.	Quercetin	33-42	kinase insert domain receptor	Homo sapiens	121-127
35199059-5	2022	We demonstrate that the binding is mediated by quercetin, and the interaction of NPs with VEGFR2 leads to disruption of the existing tumor vasculature and inhibition of new vessel development.	Quercetin	47-56	kinase insert domain receptor	Homo sapiens	90-96
35087597-7	2022	In the clothianidin + quercetin (10 mg/kg) group, the ALT and AST enzyme levels decreased compared to the clothianidin control group significantly (P < 0.05).	Quercetin	22-31	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	62-65
35064144-10	2022	Then, in vitro experiments showed that quercetin interfered with Th1/Th2 balance by acting on IL-6 and IFN-gamma to modulate the immune system in treating OLP.	Quercetin	39-48	interleukin 6	Homo sapiens	94-98
35064144-10	2022	Then, in vitro experiments showed that quercetin interfered with Th1/Th2 balance by acting on IL-6 and IFN-gamma to modulate the immune system in treating OLP.	Quercetin	39-48	interferon gamma	Homo sapiens	103-112
35162967-0	2022	Quercetin Reduces Lipid Accumulation in a Cell Model of NAFLD by Inhibiting De Novo Fatty Acid Synthesis through the Acetyl-CoA Carboxylase 1/AMPK/PP2A Axis.	Quercetin	0-9	acetyl-CoA carboxylase alpha	Homo sapiens	117-141
35162967-0	2022	Quercetin Reduces Lipid Accumulation in a Cell Model of NAFLD by Inhibiting De Novo Fatty Acid Synthesis through the Acetyl-CoA Carboxylase 1/AMPK/PP2A Axis.	Quercetin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	142-146
35162967-0	2022	Quercetin Reduces Lipid Accumulation in a Cell Model of NAFLD by Inhibiting De Novo Fatty Acid Synthesis through the Acetyl-CoA Carboxylase 1/AMPK/PP2A Axis.	Quercetin	0-9	protein phosphatase 2 phosphatase activator	Homo sapiens	147-151
35162967-6	2022	Quercetin (Que), a flavonoid with strong antioxidant properties, and noticeably reduced the lipid accumulation and the expression of SREBP-1 and XBP-1, as well as of their lipogenic gene targets in steatotic cells.	Quercetin	0-9	sterol regulatory element binding transcription factor 1	Homo sapiens	133-140
35162967-6	2022	Quercetin (Que), a flavonoid with strong antioxidant properties, and noticeably reduced the lipid accumulation and the expression of SREBP-1 and XBP-1, as well as of their lipogenic gene targets in steatotic cells.	Quercetin	0-9	X-box binding protein 1	Homo sapiens	145-150
35162967-6	2022	Quercetin (Que), a flavonoid with strong antioxidant properties, and noticeably reduced the lipid accumulation and the expression of SREBP-1 and XBP-1, as well as of their lipogenic gene targets in steatotic cells.	Quercetin	11-14	sterol regulatory element binding transcription factor 1	Homo sapiens	133-140
35162967-6	2022	Quercetin (Que), a flavonoid with strong antioxidant properties, and noticeably reduced the lipid accumulation and the expression of SREBP-1 and XBP-1, as well as of their lipogenic gene targets in steatotic cells.	Quercetin	11-14	X-box binding protein 1	Homo sapiens	145-150
35162967-8	2022	The high level of ACACA phosphorylation in Que-treated cells was explained by the intervention of AMPK together with the reduction of enzymatic activity of PP2A phosphatase.	Quercetin	43-46	acetyl-CoA carboxylase alpha	Homo sapiens	18-23
35162967-8	2022	The high level of ACACA phosphorylation in Que-treated cells was explained by the intervention of AMPK together with the reduction of enzymatic activity of PP2A phosphatase.	Quercetin	43-46	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	98-102
35162967-8	2022	The high level of ACACA phosphorylation in Que-treated cells was explained by the intervention of AMPK together with the reduction of enzymatic activity of PP2A phosphatase.	Quercetin	43-46	protein phosphatase 2 phosphatase activator	Homo sapiens	156-160
35162967-9	2022	Overall, our findings highlight a direct anti-lipogenic effect of Que exerted through inhibition of the DNL pathway by acting on ACACA/AMPK/PP2A axis; thus, suggesting this flavonoid as a promising molecule for the NAFLD treatment.	Quercetin	66-69	acetyl-CoA carboxylase alpha	Homo sapiens	129-134
35162967-9	2022	Overall, our findings highlight a direct anti-lipogenic effect of Que exerted through inhibition of the DNL pathway by acting on ACACA/AMPK/PP2A axis; thus, suggesting this flavonoid as a promising molecule for the NAFLD treatment.	Quercetin	66-69	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	135-139
35162967-9	2022	Overall, our findings highlight a direct anti-lipogenic effect of Que exerted through inhibition of the DNL pathway by acting on ACACA/AMPK/PP2A axis; thus, suggesting this flavonoid as a promising molecule for the NAFLD treatment.	Quercetin	66-69	protein phosphatase 2 phosphatase activator	Homo sapiens	140-144
35056712-8	2022	EGCG, present in green and black tea, and quercetin, present in all three teas, also inhibited PGE2 formation and expression of mPGES-1, COX-2 and cPLA2.	Quercetin	42-51	prostaglandin E synthase	Mus musculus	128-135
35056712-8	2022	EGCG, present in green and black tea, and quercetin, present in all three teas, also inhibited PGE2 formation and expression of mPGES-1, COX-2 and cPLA2.	Quercetin	42-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	137-142
35056712-8	2022	EGCG, present in green and black tea, and quercetin, present in all three teas, also inhibited PGE2 formation and expression of mPGES-1, COX-2 and cPLA2.	Quercetin	42-51	phospholipase A2 group IVA	Homo sapiens	147-152
35070983-13	2021	The KEGG pathway analysis revealed that quercetin and cisplatin may affect cervical cancer through platinum drug resistance and the p53 and HIF-1 pathways.	Quercetin	40-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-145
35070983-14	2021	Furthermore, quercetin combined with cisplatin downregulated the expression of EGFR, MYC, CCND1, and ERBB2 proteins and upregulated CASP8 expression in HeLa and SiHa cells.	Quercetin	13-22	epidermal growth factor receptor	Homo sapiens	79-83
35070983-14	2021	Furthermore, quercetin combined with cisplatin downregulated the expression of EGFR, MYC, CCND1, and ERBB2 proteins and upregulated CASP8 expression in HeLa and SiHa cells.	Quercetin	13-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	85-88
35070983-14	2021	Furthermore, quercetin combined with cisplatin downregulated the expression of EGFR, MYC, CCND1, and ERBB2 proteins and upregulated CASP8 expression in HeLa and SiHa cells.	Quercetin	13-22	cyclin D1	Homo sapiens	90-95
35070983-14	2021	Furthermore, quercetin combined with cisplatin downregulated the expression of EGFR, MYC, CCND1, and ERBB2 proteins and upregulated CASP8 expression in HeLa and SiHa cells.	Quercetin	13-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	101-106
35070983-14	2021	Furthermore, quercetin combined with cisplatin downregulated the expression of EGFR, MYC, CCND1, and ERBB2 proteins and upregulated CASP8 expression in HeLa and SiHa cells.	Quercetin	13-22	caspase 8	Homo sapiens	132-137
34983536-0	2022	Field application of nanoliposomes delivered quercetin by inhibiting specific hsp70 gene expression against plant virus disease.	Quercetin	45-54	heat shock protein family A (Hsp70) member 4	Homo sapiens	78-83
35069207-0	2021	Quercetin Attenuates Podocyte Apoptosis of Diabetic Nephropathy Through Targeting EGFR Signaling.	Quercetin	0-9	epidermal growth factor receptor	Mus musculus	82-86
35069207-4	2021	The results show that administration of quercetin attenuated the level of podocyte apoptosis by decreasing the expression of pro-apoptotic protein Bax, cleaved caspase 3 and increasing the expression of anti-apoptotic protein Bcl-2 in the db/db mice and HG-induced MPs.	Quercetin	40-49	BCL2-associated X protein	Mus musculus	147-150
35069207-4	2021	The results show that administration of quercetin attenuated the level of podocyte apoptosis by decreasing the expression of pro-apoptotic protein Bax, cleaved caspase 3 and increasing the expression of anti-apoptotic protein Bcl-2 in the db/db mice and HG-induced MPs.	Quercetin	40-49	B cell leukemia/lymphoma 2	Mus musculus	226-231
35069207-5	2021	Furthermore, epidermal growth factor receptor (EGFR) was predicted to be the potential physiological target of quercetin by network pharmacology.	Quercetin	111-120	epidermal growth factor receptor	Mus musculus	13-45
35069207-5	2021	Furthermore, epidermal growth factor receptor (EGFR) was predicted to be the potential physiological target of quercetin by network pharmacology.	Quercetin	111-120	epidermal growth factor receptor	Mus musculus	47-51
35069207-6	2021	In vitro and vivo experiments confirmed that quercetin inhibited activation of the EGFR signaling pathway by decreasing phosphorylation of EGFR and ERK1/2.	Quercetin	45-54	epidermal growth factor receptor	Mus musculus	83-87
35069207-6	2021	In vitro and vivo experiments confirmed that quercetin inhibited activation of the EGFR signaling pathway by decreasing phosphorylation of EGFR and ERK1/2.	Quercetin	45-54	epidermal growth factor receptor	Mus musculus	139-143
35069207-6	2021	In vitro and vivo experiments confirmed that quercetin inhibited activation of the EGFR signaling pathway by decreasing phosphorylation of EGFR and ERK1/2.	Quercetin	45-54	mitogen-activated protein kinase 3	Mus musculus	148-154
35069207-7	2021	Taken together, this study demonstrates that quercetin attenuated podocyte apoptosis through inhibiting EGFR signaling pathway, which provided a novel approach for further research of the mechanism of quercetin in the treatment of DN.	Quercetin	45-54	epidermal growth factor receptor	Mus musculus	104-108
35012428-5	2022	Based on the network diagram of "traditional Chinese medicine - component - target - disease" and KEGG analysis, quercetin might exhibit certain effects on colon cancer treatment by regulating the biological behavior of core targets related to cell apoptosis in tumors including PIK3R1, PIK3CA, Akt1, and Akt2.	Quercetin	113-122	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	279-285
35024051-13	2022	The docking results indicated that five main compounds (arachidonic acid, isorhamnetin, quercetin, kaempferol, and (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) had good binding activity with EGFR and AKT1 targets.	Quercetin	88-97	epidermal growth factor receptor	Homo sapiens	199-203
35024051-13	2022	The docking results indicated that five main compounds (arachidonic acid, isorhamnetin, quercetin, kaempferol, and (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) had good binding activity with EGFR and AKT1 targets.	Quercetin	88-97	AKT serine/threonine kinase 1	Homo sapiens	208-212
35012428-5	2022	Based on the network diagram of "traditional Chinese medicine - component - target - disease" and KEGG analysis, quercetin might exhibit certain effects on colon cancer treatment by regulating the biological behavior of core targets related to cell apoptosis in tumors including PIK3R1, PIK3CA, Akt1, and Akt2.	Quercetin	113-122	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	287-293
35012428-5	2022	Based on the network diagram of "traditional Chinese medicine - component - target - disease" and KEGG analysis, quercetin might exhibit certain effects on colon cancer treatment by regulating the biological behavior of core targets related to cell apoptosis in tumors including PIK3R1, PIK3CA, Akt1, and Akt2.	Quercetin	113-122	AKT serine/threonine kinase 1	Homo sapiens	295-299
35012428-5	2022	Based on the network diagram of "traditional Chinese medicine - component - target - disease" and KEGG analysis, quercetin might exhibit certain effects on colon cancer treatment by regulating the biological behavior of core targets related to cell apoptosis in tumors including PIK3R1, PIK3CA, Akt1, and Akt2.	Quercetin	113-122	AKT serine/threonine kinase 2	Homo sapiens	305-309
35012428-8	2022	Furthermore, PIK3CA could bind to quercetin directly, which is validated by immunocoprecipitation.	Quercetin	34-43	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	13-19
35012428-9	2022	Therefore, the activation of PI3K/AKT phosphorylation was inhibited by quercetin and moreover the expressions of apoptotic proteins caspase-3 and Bcl2-Associated X protein (BAX) were up-regulated.	Quercetin	71-80	AKT serine/threonine kinase 1	Homo sapiens	34-37
35012428-9	2022	Therefore, the activation of PI3K/AKT phosphorylation was inhibited by quercetin and moreover the expressions of apoptotic proteins caspase-3 and Bcl2-Associated X protein (BAX) were up-regulated.	Quercetin	71-80	caspase 3	Homo sapiens	132-141
35012428-9	2022	Therefore, the activation of PI3K/AKT phosphorylation was inhibited by quercetin and moreover the expressions of apoptotic proteins caspase-3 and Bcl2-Associated X protein (BAX) were up-regulated.	Quercetin	71-80	BCL2 associated X, apoptosis regulator	Homo sapiens	146-171
35054774-0	2022	A Complexed Crystal Structure of a Single-Stranded DNA-Binding Protein with Quercetin and the Structural Basis of Flavonol Inhibition Specificity.	Quercetin	76-85	single stranded DNA binding protein	Pseudomonas aeruginosa	35-70
35012428-9	2022	Therefore, the activation of PI3K/AKT phosphorylation was inhibited by quercetin and moreover the expressions of apoptotic proteins caspase-3 and Bcl2-Associated X protein (BAX) were up-regulated.	Quercetin	71-80	BCL2 associated X, apoptosis regulator	Homo sapiens	173-176
35012428-10	2022	In conclusion, the potential mechanism of nightshade lies in the activation of the PI3K/AKT signaling pathway inhibited by quercetin, thus promoting apoptosis of colon cancer cells for colon cancer treatment.	Quercetin	123-132	AKT serine/threonine kinase 1	Homo sapiens	88-91
35092245-7	2022	Quercetin effectively eliminated the imbalance of the immune system and increased the level of IL-10 and IL-4 in the serum.	Quercetin	0-9	interleukin 10	Rattus norvegicus	95-100
35054774-13	2022	This molecular evidence reveals the flavonol inhibition specificity and also extends the interactomes of the natural anticancer products myricetin and quercetin to include the OB-fold protein SSB.	Quercetin	151-160	single-stranded DNA-binding protein-like protein	Pseudomonas aeruginosa	192-195
35129398-0	2022	Quercetin attenuates the proliferation, inflammation, and oxidative stress of high glucose-induced human mesangial cells by regulating the miR-485-5p/YAP1 pathway.	Quercetin	0-9	microRNA 485	Homo sapiens	139-146
35129398-0	2022	Quercetin attenuates the proliferation, inflammation, and oxidative stress of high glucose-induced human mesangial cells by regulating the miR-485-5p/YAP1 pathway.	Quercetin	0-9	Yes1 associated transcriptional regulator	Homo sapiens	150-154
35129398-12	2022	Quercetin modulated miR-485-5p/YAP1 axis to regulate HG-induced inflammation and oxidative stress.	Quercetin	0-9	microRNA 485	Homo sapiens	20-27
35129398-12	2022	Quercetin modulated miR-485-5p/YAP1 axis to regulate HG-induced inflammation and oxidative stress.	Quercetin	0-9	Yes1 associated transcriptional regulator	Homo sapiens	31-35
35129398-13	2022	CONCLUSION: Quercetin inhibits the proliferation, inflammation, and oxidative stress of HMCs induced by HG through miR-485-5p/YAP1 axis, which might provide a novel treatment strategy for DN.	Quercetin	12-21	microRNA 485	Homo sapiens	115-122
35129398-13	2022	CONCLUSION: Quercetin inhibits the proliferation, inflammation, and oxidative stress of HMCs induced by HG through miR-485-5p/YAP1 axis, which might provide a novel treatment strategy for DN.	Quercetin	12-21	Yes1 associated transcriptional regulator	Homo sapiens	126-130
35307675-1	2022	OBJECTIVE: The aim: To study the value of C-reactive protein in the experimental animals blood serum with bacterial-immune periodontitis and its correction with quercetin.	Quercetin	161-170	C-reactive protein	Rattus norvegicus	42-60
35307675-5	2022	RESULTS: Results: Analysis of the results of the study of the content of C-reactive protein in the blood serum of animals with experimental bacteria and immune periodontitis, receiving injections of quercetin, showed a significant decrease by 1.31 times, compared with animals with this simulated pathology on the 14th day of the experiment without the use of flavonol.	Quercetin	199-208	C-reactive protein	Rattus norvegicus	73-91
35307675-8	2022	The administration of flavonoid quercetin for 7 days helps to reduce the level of C-reactive protein in the blood serum of animals with experimental bacterial and immune periodontitis.	Quercetin	32-41	C-reactive protein	Rattus norvegicus	82-100
35223435-7	2022	According to the target particle size of inhalation, Quercetin SLM had good flowability according to Carr"s Index (F1 = 12.73% +- 0.38, F2 = 14.28% +- 0.65, F3 = 14.65% +- 0.62), in which the highest drug loading and EE of F3 were 10.94% and 88.48%, respectively.	Quercetin	53-62	arrestin 3	Homo sapiens	101-105
35092245-7	2022	Quercetin effectively eliminated the imbalance of the immune system and increased the level of IL-10 and IL-4 in the serum.	Quercetin	0-9	interleukin 4	Rattus norvegicus	105-109
35262828-0	2022	In silico discovery of 3 novel quercetin derivatives against papain-like protease, spike protein, and 3C-like protease of SARS-CoV-2.	Quercetin	31-40	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	83-88
35178359-0	2021	Quercetin Arrests in G2 phase, Upregulates INXS LncRNA and Downregulates UCA1 LncRNA in MCF-7 Cells.	Quercetin	0-9	apoptotic BCL2L1-antisense long non-coding RNA	Homo sapiens	43-47
35178359-0	2021	Quercetin Arrests in G2 phase, Upregulates INXS LncRNA and Downregulates UCA1 LncRNA in MCF-7 Cells.	Quercetin	0-9	urothelial cancer associated 1	Homo sapiens	73-77
35178359-5	2021	This research aimed to assess the impact of quercetin on the expression of INXS and UCA1 genes in MCF-7 cells.	Quercetin	44-53	apoptotic BCL2L1-antisense long non-coding RNA	Homo sapiens	75-79
35178359-5	2021	This research aimed to assess the impact of quercetin on the expression of INXS and UCA1 genes in MCF-7 cells.	Quercetin	44-53	urothelial cancer associated 1	Homo sapiens	84-88
35178359-9	2021	The levels of INXS and UCA1 gene expression compared with the GAPDH gene at different concentrations of quercetin were quantified using real-time PCR method.	Quercetin	104-113	apoptotic BCL2L1-antisense long non-coding RNA	Homo sapiens	14-18
35178359-9	2021	The levels of INXS and UCA1 gene expression compared with the GAPDH gene at different concentrations of quercetin were quantified using real-time PCR method.	Quercetin	104-113	urothelial cancer associated 1	Homo sapiens	23-27
35178359-12	2021	Also, quercetin induced INXS upregulation and UCA1 downregulation in the MCF-7 cell line.	Quercetin	6-15	apoptotic BCL2L1-antisense long non-coding RNA	Homo sapiens	24-28
35178359-12	2021	Also, quercetin induced INXS upregulation and UCA1 downregulation in the MCF-7 cell line.	Quercetin	6-15	urothelial cancer associated 1	Homo sapiens	46-50
35178359-13	2021	These data suggest that quercetin might increase cell death by up regulating INXS and down regulating UCA1 lncRNAs in MCF-7 cells.	Quercetin	24-33	apoptotic BCL2L1-antisense long non-coding RNA	Homo sapiens	77-81
35178359-13	2021	These data suggest that quercetin might increase cell death by up regulating INXS and down regulating UCA1 lncRNAs in MCF-7 cells.	Quercetin	24-33	urothelial cancer associated 1	Homo sapiens	102-106
35262828-2	2022	The current study was therefore conducted to examine the noted novel derivatives of quercetin present in plant sources as an immune modulator and as an antiviral molecule in the COVID-19 disease and also to study their affinity of binding with potential three targets reported for coronavirus, i.e., papain-like protease, spike protein receptor-binding domain, and 3C-like protease.	Quercetin	84-93	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	322-327
35262828-6	2022	Docking was performed finally using PyRx having AutoDock Vina to identify the efficacy of binding between quercetin derivatives with papain-like protease, spike protein receptor-binding domain, and 3C-like protease.	Quercetin	106-115	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	155-160