PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
409034-2	1977	The transformation was effected by treatment of the red cells with the sulfydryl compounds D-penicillamine (DP) and N-acetyl-L-cysteine (NAC).	sulfydryl	71-80	X-linked Kx blood group	Homo sapiens	137-140
23223830-3	2013	We optimized an anti-5T4 ADC (A1mcMMAF) by sulfydryl-based conjugation of the humanized A1 antibody to the tubulin inhibitor monomethylauristatin F (MMAF) via a maleimidocaproyl linker.	sulfydryl	43-52	trophoblast glycoprotein	Homo sapiens	21-24
409034-5	1977	However, both DP- and NAC-treated cells showed a similar sensitivity to lysis by acid serum and about the same degree of acetylcholinesterase (AChE) activity decrease, thus indicating that the susceptibility to autoxidation of lipids is not involved in the determination of complement sensitivity or in the AChE activity decrease of the sulfydryl-treated cells.	sulfydryl	337-346	X-linked Kx blood group	Homo sapiens	22-25
33298269-2	2021	At "on" state, fluorescence enhancement of BSA-AuNCs is generated due to the reaction between cysteine and BSA-AuNCs, via filling the surface defect of gold nanoclusters, while Cu2+ can further oxidize the reductive sulfydryl of cysteine and interact with amino acids presented in the BSA chain, inducing gold nanoclusters to aggregate, thus causing "off" state with fluorescence quenching.	sulfydryl	216-225	immunoglobulin kappa variable 1-35	Mus musculus	177-180
31853650-2	2019	Gold nanospheres were functionalized with a HIF-1alpha-binding aptamer via sulfydryl chemistry.	sulfydryl	75-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-54
31853650-9	2019	Graphical abstractGold nanospheres were functionalized with a HIF-1alpha-binding aptamer via sulfydryl chemistry.	sulfydryl	93-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
31740255-4	2020	And Au nanoparticles (AuNPs) grown directly on the surface of hollow CeO2 microstructure are used to immobilize sulfydryl functionalized thrombin reporter apemeter 2 (Apt2).	sulfydryl	112-121	coagulation factor II, thrombin	Homo sapiens	137-145
30340695-2	2018	In this work, the sulfydryl aptamer selected for OH-PCB was easily immobilized on the surface of the modified glassy carbon electrode via Au-S bond due to incorporation of gold nanoparticles/poly dimethyl diallyl ammonium chloride-graphene composite.	sulfydryl	18-27	pyruvate carboxylase	Homo sapiens	52-55
29853067-4	2018	In this study, gold nanorods modified with (11-mercapto-undecyl)-trimethylammonium (MTA) molecules containing sulfydryl groups were designed and synthesized for the photoacoustic detection of mercury ions (Hg2+).	sulfydryl	110-119	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	206-209
29853067-5	2018	In the present of Hg2+, MTA molecules would be displaced quickly from the surface of gold nanorods due to the high affinity of Hg2+ toward sulfydryl group.	sulfydryl	139-148	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	18-21
29853067-5	2018	In the present of Hg2+, MTA molecules would be displaced quickly from the surface of gold nanorods due to the high affinity of Hg2+ toward sulfydryl group.	sulfydryl	139-148	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	127-130
26908183-2	2016	A sulfydryl-labeled thrombin capture probe (Apt1) and a biotin-labeled thrombin reporter probe (Apt2) were designed to achieve a sandwich-type strategy.	sulfydryl	2-11	coagulation factor II, thrombin	Homo sapiens	20-28
22317835-4	2012	Sulfydryl functionalized locked nucleic acid (LNA) integrated hairpin molecule beacon (MB) probe was used as miRNA-21 capture probe.	sulfydryl	0-9	microRNA 21	Homo sapiens	109-117
21928345-8	2012	Reactive nitrogen species (RNS) may affect protein targets, such as TIMP-1, which are crucial for the regulation of MMP activities by oxidation of sulfydryl groups, or by nitration of tyrosine residues.	sulfydryl	147-156	TIMP metallopeptidase inhibitor 1	Homo sapiens	68-74
17907785-7	2007	Following incubations with NADPH- and GSH-supplemented human liver microsomes and S-9, three sulfydryl conjugates with MH(+) ions at 623 Da (GS1), 779 Da (GS2), and 928 Da (GS3), respectively, were detected by LC-MS/MS.	sulfydryl	93-102	2,4-dienoyl-CoA reductase 1	Homo sapiens	27-32
19460788-10	2009	Apoptosis induced by TN is driven by oxidative stress and cell exposure to sulfydryl donors, such as glutathione monoethylester and l-N-acetylcysteine, significantly reduced pro-apoptotic effects and Akt inhibition.	sulfydryl	75-84	AKT serine/threonine kinase 1	Homo sapiens	200-203
17714694-6	2007	It appears that Band 3 phosphorylation is due to the oxidation of critical sulfydryl groups of a membrane phosphatase (PTP).	sulfydryl	75-84	protein tyrosine phosphatase receptor type U	Homo sapiens	119-122
17907785-7	2007	Following incubations with NADPH- and GSH-supplemented human liver microsomes and S-9, three sulfydryl conjugates with MH(+) ions at 623 Da (GS1), 779 Da (GS2), and 928 Da (GS3), respectively, were detected by LC-MS/MS.	sulfydryl	93-102	ribosomal protein S9	Homo sapiens	82-85
12869559-0	2003	Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors.	sulfydryl	113-122	arginine vasopressin receptor 1A	Homo sapiens	82-106
16876179-0	2006	Interfacial and foaming properties of sulfydryl-modified bovine beta-lactoglobulin.	sulfydryl	38-47	beta-lactoglobulin	Bos taurus	64-82
16876179-2	2006	Compared to native beta-lactoglobulin (unmodified beta-lactoglobulin), sulfydryl-modified beta-lactoglobulin exhibited higher surface hydrophobicity, adsorbed faster at the air/water interface, had the capability to develop rapidly an interfacial layer with high shear elastic constant but exhibited a considerably lower shear elastic constant plateau value.	sulfydryl	71-80	beta-lactoglobulin	Bos taurus	19-37
16876179-2	2006	Compared to native beta-lactoglobulin (unmodified beta-lactoglobulin), sulfydryl-modified beta-lactoglobulin exhibited higher surface hydrophobicity, adsorbed faster at the air/water interface, had the capability to develop rapidly an interfacial layer with high shear elastic constant but exhibited a considerably lower shear elastic constant plateau value.	sulfydryl	71-80	beta-lactoglobulin	Bos taurus	50-68
16876179-2	2006	Compared to native beta-lactoglobulin (unmodified beta-lactoglobulin), sulfydryl-modified beta-lactoglobulin exhibited higher surface hydrophobicity, adsorbed faster at the air/water interface, had the capability to develop rapidly an interfacial layer with high shear elastic constant but exhibited a considerably lower shear elastic constant plateau value.	sulfydryl	71-80	beta-lactoglobulin	Bos taurus	50-68
17200109-4	2007	Using co-immunoprecipitation assays of solubilized native RyR2 from cardiac muscle sarcoplasmic reticulum (SR) with recombinant [(35)S]FKBP12.6, we found that the sulfydryl-oxidizing agents, H(2)O(2) and diamide, result in diminished RyR2-FKBP12.6 binding.	sulfydryl	163-172	ryanodine receptor 2	Homo sapiens	58-62
17200109-4	2007	Using co-immunoprecipitation assays of solubilized native RyR2 from cardiac muscle sarcoplasmic reticulum (SR) with recombinant [(35)S]FKBP12.6, we found that the sulfydryl-oxidizing agents, H(2)O(2) and diamide, result in diminished RyR2-FKBP12.6 binding.	sulfydryl	163-172	FKBP prolyl isomerase 1B	Homo sapiens	135-143
17200109-4	2007	Using co-immunoprecipitation assays of solubilized native RyR2 from cardiac muscle sarcoplasmic reticulum (SR) with recombinant [(35)S]FKBP12.6, we found that the sulfydryl-oxidizing agents, H(2)O(2) and diamide, result in diminished RyR2-FKBP12.6 binding.	sulfydryl	163-172	ryanodine receptor 2	Homo sapiens	234-238
17200109-4	2007	Using co-immunoprecipitation assays of solubilized native RyR2 from cardiac muscle sarcoplasmic reticulum (SR) with recombinant [(35)S]FKBP12.6, we found that the sulfydryl-oxidizing agents, H(2)O(2) and diamide, result in diminished RyR2-FKBP12.6 binding.	sulfydryl	163-172	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	135-141
12869559-1	2003	To identify the binding site of the human V1a vasopressin receptor for the selective nonpeptide antagonist SR49059, we have developed a site-directed irreversible labeling strategy that combines mutagenesis of the receptor and use of sulfydryl-reactive ligands.	sulfydryl	234-243	arginine vasopressin receptor 1A	Homo sapiens	42-66
12194971-13	2002	N-Acetylcysteine almost completely abolished AS-mediated induction of HO-1, whereas a glutathione synthesis inhibitor (buthionine sulfoximine) significantly decreased heme oxygenase activation by AS, indicating that sulfydryl groups are crucial targets in the regulation of HO-1 expression by NO(-).	sulfydryl	216-225	heme oxygenase 1	Rattus norvegicus	70-74
12194971-13	2002	N-Acetylcysteine almost completely abolished AS-mediated induction of HO-1, whereas a glutathione synthesis inhibitor (buthionine sulfoximine) significantly decreased heme oxygenase activation by AS, indicating that sulfydryl groups are crucial targets in the regulation of HO-1 expression by NO(-).	sulfydryl	216-225	heme oxygenase 1	Rattus norvegicus	274-278
11854435-9	2002	These data suggest that regulation of HO-1 expression by polyphenolic compounds is evoked by a distinctive mechanism which is not necessarily linked to changes in glutathione but might depend on redox signals sustained by specific and targeted sulfydryl groups.	sulfydryl	244-253	heme oxygenase 1	Homo sapiens	38-42
20654547-6	1999	The use of these fluorescent probes provide a useful and rapid methods for future screening of protective molecules against the early sulfydryl depletion and oxidative stress induced by HN2 on human airway epithelium.	sulfydryl	134-143	MT-RNR2 like 2 (pseudogene)	Homo sapiens	186-189