PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7391953-0	1980	Ligand interaction of sustituted pyridines with cytochrome P-450.	Pyridines	33-42	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	48-64
3564801-3	1986	These substituted pyridines gave pyridyl-N-and/or pyridyl-O-substituted derivatives, depending both upon the position of the hydroxyl and methyl groups in the pyridine ring, at the C-4 and the C-6 of the uracil and guanine residues, respectively.	Pyridines	18-27	complement C4A (Rodgers blood group)	Homo sapiens	181-184
3564801-3	1986	These substituted pyridines gave pyridyl-N-and/or pyridyl-O-substituted derivatives, depending both upon the position of the hydroxyl and methyl groups in the pyridine ring, at the C-4 and the C-6 of the uracil and guanine residues, respectively.	Pyridines	18-27	complement C6	Homo sapiens	193-196
6688177-1	1983	The present work shows that the ability of pyridines e.g. metyrapone, to maintain the cytochrome P-450 concentration in cultured hepatocytes is not due to their ability to alter the 5-aminolaevulinate synthase and haem oxygenase activities of the hepatocytes.	Pyridines	43-52	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	86-102
6329231-2	1984	A combination of nicotinamide or other pyridines with dexamethasone was shown to maintain ECD at or above the activity of untreated livers in vivo and to potentiate induction by xenobiotics.	Pyridines	39-48	ecdysoneless cell cycle regulator	Rattus norvegicus	90-93
7470047-4	1980	The efficiency of pyridines at maintaining cytochrome P-450 in hepatocyte culture is highly correlated with their ability to bind to this cytochrome, suggesting that ligand formation with cytochrome P-450 prevents its accelerated turnover in liver cell culture.	Pyridines	18-27	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	43-59
7470047-2	1980	The loss of cytochrome P-450 in cultured rat hepatocytes can be prevented by substituted pyridines, especially isonicotinamide, 3-hydroxypyridine and metyrapone.	Pyridines	89-98	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	12-28
7406903-0	1980	The relationship between the ability of pyridine and substituted pyridines to maintain cytochrome P-450 and inhibit protein synthesis in rat hepatocyte cultures.	Pyridines	65-74	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	87-103
7470047-4	1980	The efficiency of pyridines at maintaining cytochrome P-450 in hepatocyte culture is highly correlated with their ability to bind to this cytochrome, suggesting that ligand formation with cytochrome P-450 prevents its accelerated turnover in liver cell culture.	Pyridines	18-27	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	188-204
483858-9	1979	Any treatment of microsomes which resulted in a reduction of cytochrome P-450 also produced a concomitant fall in N-oxidation of the pyridines.	Pyridines	133-142	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	61-77
7373548-0	1980	Inhibition of in vitro cytochrome P-450-catalyzed reactions by substituted pyridines.	Pyridines	75-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	23-39
7373548-1	1980	A series of substituted pyridines was investigated as inhibitors of cytochrome P-450-catalyzed reactions.	Pyridines	24-33	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	68-84
5066098-0	1972	[Studies in the nature of ligand receptor relations in methemoglobin complexes with imidazols,1,2,4-triazol and pyridines].	Pyridines	112-121	hemoglobin subunit gamma 2	Homo sapiens	55-68
184092-8	1976	The complexes of ferrous leghemoglobin with substituted pyridines exhibit optical absorption maxima near 685 nm, whose absorption maxima and extinctions are strongly dependent on the nature of the substitutents of the pyridine ring; electron withdrawing groups on the pyridine ring shift the absorption maxima to lower energy.	Pyridines	56-65	leghemoglobin A	Glycine max	25-38
31322352-0	2019	Photoarylation of Pyridines Using Aryldiazonium Salts and Visible Light: An EDA Approach.	Pyridines	18-27	ectodysplasin A	Homo sapiens	76-79
4295158-0	1968	Charge-transfer character of glucose dehydrogenase inhibition by substituted pyridines.	Pyridines	77-86	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	29-50
32622979-3	2020	Nicotinamide N-methyltransferase (NNMT) is a major metabolic enzyme involved in epigenetic regulation through catalysis of methyl transfer from the cofactor S-adenosyl-L-methionine onto nicotinamide and other pyridines.	Pyridines	209-218	nicotinamide N-methyltransferase	Homo sapiens	0-32
32622979-3	2020	Nicotinamide N-methyltransferase (NNMT) is a major metabolic enzyme involved in epigenetic regulation through catalysis of methyl transfer from the cofactor S-adenosyl-L-methionine onto nicotinamide and other pyridines.	Pyridines	209-218	nicotinamide N-methyltransferase	Homo sapiens	34-38
32324994-1	2020	We report the development of a multifunctional reagent for the direct conversion of pyridines to Boc-protected 2-aminopyridines with exquisite site- and chemoselectivity.	Pyridines	84-93	BOC cell adhesion associated, oncogene regulated	Homo sapiens	97-100
32155060-1	2020	Ruthenium complexes containing the tetradentate 2,2"-bipyridine-6,6"-dicarboxylato (bda2-) equatorial ligand and ortho-subsituted pyridines in the axial position have been prepared and characterized using spectroscopic, crystallographic and electrochemical techniques.	Pyridines	130-139	bone morphogenetic protein 2	Homo sapiens	84-88
32329338-1	2020	An alternative process of Pd-catalyzed C-4 selective coupling of 2,4-dichloropyridines with boronic esters was developed, which afforded 24 examples of C-4 coupled pyridines in moderate to good yields.	Pyridines	77-86	complement C4A (Rodgers blood group)	Homo sapiens	39-42
32329338-1	2020	An alternative process of Pd-catalyzed C-4 selective coupling of 2,4-dichloropyridines with boronic esters was developed, which afforded 24 examples of C-4 coupled pyridines in moderate to good yields.	Pyridines	77-86	complement C4A (Rodgers blood group)	Homo sapiens	152-155
30761702-2	2019	Upon addition of pyridine, both NiII centers became hexacoordinated by accepting two axial pyridines, which triggered a spin-state change of the NiII centers from diamagnetic (S=0) to paramagnetic (S=1).	Pyridines	91-100	spindlin 1	Homo sapiens	120-124
30344447-1	2018	The robust CoI precatalyst [CpCo(P{OEt}3)(trans-MeO2CHC=CHCO2Me)] was investigated in cyclotrimerizations, furnishing benzenes and pyridines from triynes, diynes and nitriles, comparing the influence of different ways of energy supply; namely, irradiation and conventional (thermal) or microwave heating.	Pyridines	131-140	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	11-14
30291899-4	2019	Several different scaffolds have been identified as P2Y12 receptor antagonists, including irreversibly acting thienotetrahydropyridines (prodrugs), and reversible competitive antagonists, including adenine nucleotide analogs, piperazinyl-glutamate-quinolines, -pyridines, and -pyrimidines, and anthraquinone derivatives.	Pyridines	126-135	purinergic receptor P2Y12	Homo sapiens	52-57
30103189-7	2018	The >100-fold reduced GluN2B affinity of pyridines 11b and 11c compared to the GluN2B affinity of the corresponding chloro- and nitrobenzene derivatives 3d and 3e indicates that the pyridine ring is not tolerated as bioisosteric replacement of the chloro- or nitrobenzene ring in this type of compounds.	Pyridines	44-53	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	25-31
29914120-7	2018	Pyridines 8b and 8e were screened in vitro for their inhibitory activity against VEGFR-2.	Pyridines	0-9	kinase insert domain receptor	Homo sapiens	81-88
29938019-1	2018	The trans-tetrafluoro-lambda6-sulfane (SF4) group has been utilized as a unique three-dimensional building block for the linear connection of two independent N-heterocycles, pyridines and triazoles.	Pyridines	174-183	SURP and G-patch domain containing 1	Homo sapiens	39-42
29112403-0	2017	Selective ortho C-H Activation of Pyridines Directed by Lewis Acidic Boron of PBP Pincer Iridium Complexes.	Pyridines	34-43	phosphatidylethanolamine binding protein 1	Homo sapiens	78-81
29566331-11	2018	Strikingly, 2-guanidino-quinolines and -pyridines showed a concentration-dependent biphasic effect that resulted at higher concentrations in ASIC1a and ASIC3 inhibition (IC50 > 100 muM), while causing at lower concentration a potentiation of ASIC1a, but not ASIC3 currents (EC50   10 muM).	Pyridines	39-49	acid sensing ion channel subunit 3	Homo sapiens	152-157
29566331-11	2018	Strikingly, 2-guanidino-quinolines and -pyridines showed a concentration-dependent biphasic effect that resulted at higher concentrations in ASIC1a and ASIC3 inhibition (IC50 > 100 muM), while causing at lower concentration a potentiation of ASIC1a, but not ASIC3 currents (EC50   10 muM).	Pyridines	39-49	acid sensing ion channel subunit 3	Homo sapiens	261-266
29207138-0	2018	Anticancer pyridines induce G2/M arrest and apoptosis via p53 and JNK upregulation in liver and breast cancer cells.	Pyridines	11-20	tumor protein p53	Homo sapiens	58-61
29207138-0	2018	Anticancer pyridines induce G2/M arrest and apoptosis via p53 and JNK upregulation in liver and breast cancer cells.	Pyridines	11-20	mitogen-activated protein kinase 8	Homo sapiens	66-69
28720493-1	2017	Nicotinamide N-methyltransferase (NNMT) is a S-adenosyl-l-methionine (SAM)-dependent enzyme that catalyzes N-methylation of nicotinamide (NA) and other pyridines to form N-methyl pyridinium ions.	Pyridines	152-161	nicotinamide N-methyltransferase	Mus musculus	0-32
28720493-1	2017	Nicotinamide N-methyltransferase (NNMT) is a S-adenosyl-l-methionine (SAM)-dependent enzyme that catalyzes N-methylation of nicotinamide (NA) and other pyridines to form N-methyl pyridinium ions.	Pyridines	152-161	nicotinamide N-methyltransferase	Mus musculus	34-38
25075329-3	2014	The decreased catalytic activity (~20-fold lower with respect to the wild type) of a variant of CA II in which His64 is replaced with Ala (H64A CA II) can be enhanced by exogenous proton donors/acceptors, usually derivatives of imidazoles and pyridines, to almost the wild-type level.	Pyridines	243-252	carbonic anhydrase 2	Homo sapiens	96-101
28579121-2	2017	By applying the strategy to the previously identified templates, quinoline 4 and pyridines 16a, 16b, and 17 have been identified as subnanomolar or nanomolar inhibitors of human DPP-4.	Pyridines	81-90	dipeptidyl peptidase 4	Homo sapiens	178-183
28458366-2	2017	Two series of novel alkoxylated 2-oxo(imino)-3-pyridinecarbonitriles (structurally-relevant to some reported anticancer pyridines with phosphodiesterase 3A (PDE3A) inhibitory activity) were synthesized and evaluated for their in vitro differential tumor cell growth inhibitory potential against the breast MCF7, hepatocellular Hep-G2, colon CACO-2 cell lines, and a normal human foreskin fibroblast Hs27 cell line.	Pyridines	120-129	phosphodiesterase 3A	Homo sapiens	135-155
28458366-2	2017	Two series of novel alkoxylated 2-oxo(imino)-3-pyridinecarbonitriles (structurally-relevant to some reported anticancer pyridines with phosphodiesterase 3A (PDE3A) inhibitory activity) were synthesized and evaluated for their in vitro differential tumor cell growth inhibitory potential against the breast MCF7, hepatocellular Hep-G2, colon CACO-2 cell lines, and a normal human foreskin fibroblast Hs27 cell line.	Pyridines	120-129	phosphodiesterase 3A	Homo sapiens	157-162
27541271-2	2016	Throughout our NAMPT inhibitor program, we found that exposed pyridines or related heterocyclic systems in the left-hand portion of the inhibitors are necessary pharmacophores for potent cellular NAMPT inhibition.	Pyridines	62-71	nicotinamide phosphoribosyltransferase	Mus musculus	15-20
27541271-2	2016	Throughout our NAMPT inhibitor program, we found that exposed pyridines or related heterocyclic systems in the left-hand portion of the inhibitors are necessary pharmacophores for potent cellular NAMPT inhibition.	Pyridines	62-71	nicotinamide phosphoribosyltransferase	Mus musculus	196-201
27541271-5	2016	A spirocyclic central motif was thus discovered that was combined with left-hand pyridines (or pyridine-like systems) to provide cellularly potent NAMPT inhibitors with minimal CYP2C9 inhibition.	Pyridines	81-90	nicotinamide phosphoribosyltransferase	Mus musculus	147-152
26485179-2	2015	Ligands HL1 and HL3 contain two pyridines, amine and alcohol moieties with a naphthyl pendant unit yielding a N3O coordination metal environment.	Pyridines	32-41	asialoglycoprotein receptor 1	Homo sapiens	8-11
26485179-2	2015	Ligands HL1 and HL3 contain two pyridines, amine and alcohol moieties with a naphthyl pendant unit yielding a N3O coordination metal environment.	Pyridines	32-41	dynein cytoplasmic 1 heavy chain 1	Homo sapiens	16-19
26308773-8	2015	In the presence of pyridines, irreversible oxidation waves are observed, suggesting that these ligands destabilize the Rh2 complex under oxidative conditions.	Pyridines	19-28	Rh associated glycoprotein	Homo sapiens	119-122
24838670-0	2014	Metal-free (Boc)2O-mediated C4-selective direct indolation of pyridines using TEMPO.	Pyridines	62-71	BOC cell adhesion associated, oncogene regulated	Homo sapiens	12-15
24838670-1	2014	Direct metal-free C-4-selective indolation of pyridines is achieved for the first time using TEMPO and (Boc)2O.	Pyridines	46-55	BOC cell adhesion associated, oncogene regulated	Homo sapiens	104-107
27966934-1	2017	An unprecedented intramolecular acylation of unactivated pyridines via multiple C(sp3/sp2)-H functionalizations of a methyl, hydroxymethyl, or aldehyde group has been developed providing a general access to all four azafluorenones.	Pyridines	57-66	Sp2 transcription factor	Homo sapiens	86-89
27731999-2	2016	A reaction that selectively transforms the 4-position C-H bonds in pyridines into C-PPh3+ groups that are subsequently converted into heteroaryl ethers is presented.	Pyridines	67-76	protein phosphatase 4 catalytic subunit	Homo sapiens	84-88
27245438-0	2016	Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2).	Pyridines	23-32	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	50-70
27245438-0	2016	Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2).	Pyridines	23-32	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	72-79
25815155-0	2015	Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists.	Pyridines	54-63	5-hydroxytryptamine receptor 2C	Homo sapiens	74-80
24560625-3	2014	Substrate dependency and high selectivity in binding of naphthoquinone tethered carboxylic acids or pyridines with bovine serum albumin (BSA) and human serum albumin (HSA) are observed.	Pyridines	100-109	albumin	Homo sapiens	122-141
24560625-3	2014	Substrate dependency and high selectivity in binding of naphthoquinone tethered carboxylic acids or pyridines with bovine serum albumin (BSA) and human serum albumin (HSA) are observed.	Pyridines	100-109	albumin	Homo sapiens	122-135
25075329-3	2014	The decreased catalytic activity (~20-fold lower with respect to the wild type) of a variant of CA II in which His64 is replaced with Ala (H64A CA II) can be enhanced by exogenous proton donors/acceptors, usually derivatives of imidazoles and pyridines, to almost the wild-type level.	Pyridines	243-252	carbonic anhydrase 2	Homo sapiens	144-149
23253443-1	2013	A series of substituted pyridines, ether linked to a phenylpiperidine core were optimized for dual NK(1)/SERT affinity.	Pyridines	24-33	solute carrier family 6 member 4	Homo sapiens	105-109
24047900-7	2013	The structures suggest that although a precise fit between the shape of the inhibitor molecules and T. cruzi CYP51 active site topology underlies their high inhibitory potency, a longer coordination bond between the catalytic heme iron and the pyridine nitrogen implies a weaker influence of pyridines on the iron reduction potential, which may be the basis for the observed selectivity of these compounds toward the target enzyme versus other cytochrome P450s, including human drug-metabolizing P450s.	Pyridines	292-301	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	109-114
25214702-0	2013	Mechanistic Evaluation of the Ni(IPr)2-Catalyzed Cycloaddition of Alkynes and Nitriles to Afford Pyridines: Evidence for the Formation of a Key eta1-Ni(IPr)2(RCN) Intermediate.	Pyridines	97-106	secreted phosphoprotein 1	Homo sapiens	144-148
25214702-0	2013	Mechanistic Evaluation of the Ni(IPr)2-Catalyzed Cycloaddition of Alkynes and Nitriles to Afford Pyridines: Evidence for the Formation of a Key eta1-Ni(IPr)2(RCN) Intermediate.	Pyridines	97-106	reticulocalbin 1	Homo sapiens	158-161
22386564-2	2012	The moderate and non-selective aromatase inhibitory activity of resveratrol (1) was improved about 100-fold by replacement of the ethylenic bridge with a thiadiazole and the phenyl rings with pyridines (e.g., compound 3).	Pyridines	192-201	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	31-40
22917161-0	2012	The discovery of [Ni(NHC)RCN]2 species and their role as cycloaddition catalysts for the formation of pyridines.	Pyridines	102-111	reticulocalbin 2	Homo sapiens	25-30
21823666-1	2011	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridines, and other analogues using S-adenosyl-l-methionine as donor.	Pyridines	85-94	nicotinamide N-methyltransferase	Homo sapiens	0-32
22075973-1	2012	A conceptually new three-component reaction was developed to construct a six-membered fused N-heterocyclic ring affording (pyrazolo)pyrimidines/pyridines as potential inhibitors of PDE4.	Pyridines	144-153	phosphodiesterase 4A	Homo sapiens	181-185
21823666-1	2011	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridines, and other analogues using S-adenosyl-l-methionine as donor.	Pyridines	85-94	nicotinamide N-methyltransferase	Homo sapiens	34-38
20006500-0	2010	Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines.	Pyridines	17-26	thymoma viral proto-oncogene 1	Mus musculus	51-54
21458260-0	2011	Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.	Pyridines	25-34	histamine receptor H4	Homo sapiens	38-61
21491938-0	2011	Ligand-promoted C-3 selective C-H olefination of pyridines with Pd catalysts.	Pyridines	49-58	complement C3	Homo sapiens	16-19
21491938-1	2011	Pd-catalyzed C-3 selective olefination of pyridines is developed for the first time using 1,10-phenanthroline as the ligand.	Pyridines	42-51	complement C3	Homo sapiens	13-16
21353545-2	2011	A structure-activity relationship study of 2,4-diaminothiazole inhibitors revealed that increased Cdk5/p25 inhibitory activity could be accomplished by incorporating pyridines on the 2-amino group and addition of substituents to the 2- or 3-position of the phenyl ketone moiety.	Pyridines	166-175	cyclin-dependent kinase 5	Mus musculus	98-102
21353545-2	2011	A structure-activity relationship study of 2,4-diaminothiazole inhibitors revealed that increased Cdk5/p25 inhibitory activity could be accomplished by incorporating pyridines on the 2-amino group and addition of substituents to the 2- or 3-position of the phenyl ketone moiety.	Pyridines	166-175	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	103-106
21496389-1	2011	The enzyme Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide and other pyridines, playing a pivotal role in the biotransformation and detoxification of many drugs and xenobiotic compounds.	Pyridines	103-112	nicotinamide N-methyltransferase	Homo sapiens	11-43
21496389-1	2011	The enzyme Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide and other pyridines, playing a pivotal role in the biotransformation and detoxification of many drugs and xenobiotic compounds.	Pyridines	103-112	nicotinamide N-methyltransferase	Homo sapiens	45-49
20006500-0	2010	Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines.	Pyridines	17-26	ETS transcription factor ERG	Homo sapiens	86-90
18247621-0	2008	A strategy for C-H activation of pyridines: direct C-2 selective alkenylation of pyridines by nickel/Lewis acid catalysis.	Pyridines	81-90	complement C2	Homo sapiens	51-54
19193046-0	2009	Sc(OTf)3-catalyzed direct alkylation of quinolines and pyridines with alkanes.	Pyridines	55-64	POU class 5 homeobox 1	Homo sapiens	0-8
19193046-1	2009	The Sc(OTf)(3)-catalyzed C-C bond formation by direct alkylation of quinolines and pyridines using simple alkanes was developed.	Pyridines	83-92	POU class 5 homeobox 1	Homo sapiens	4-13
18247621-0	2008	A strategy for C-H activation of pyridines: direct C-2 selective alkenylation of pyridines by nickel/Lewis acid catalysis.	Pyridines	33-42	complement C2	Homo sapiens	51-54
15728403-2	2005	N-methylated pyridines (e.g. MPP+) are well-established dopaminergic toxins, and the xenobiotic enzyme nicotinamide N-methyltransferase (NNMT) can convert pyridines such as 4-phenylpyridine into MPP+, using S-adenosyl methionine (SAM) as the methyl donor.	Pyridines	13-22	nicotinamide N-methyltransferase	Homo sapiens	103-135
17362020-2	2007	The unsaturated ketones and aldehydes derived from the cycloisomerization of primary and secondary propargyl diynols in the presence of [CpRu(CH3CN)3]PF6 (1) are converted to 1-azatrienes which in turn undergo a subsequent electrocyclization-dehydration to provide pyridines with excellent regiocontrol.	Pyridines	265-274	sperm associated antigen 17	Homo sapiens	150-153
17352678-4	2007	DPP-IV inhibitors related to the xanthines include purine analogues with other arrangements of the nitrogen atoms in the core structure, imidazoles, uracils, pyrimidines, pyridines, and some fused pyridines.	Pyridines	171-180	dipeptidyl peptidase 4	Homo sapiens	0-6
17352678-4	2007	DPP-IV inhibitors related to the xanthines include purine analogues with other arrangements of the nitrogen atoms in the core structure, imidazoles, uracils, pyrimidines, pyridines, and some fused pyridines.	Pyridines	197-206	dipeptidyl peptidase 4	Homo sapiens	0-6
15908473-0	2005	Effects of dihydropyridines and pyridines on multidrug resistance mediated by breast cancer resistance protein: in vitro and in vivo studies.	Pyridines	18-27	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	78-110
15908473-2	2005	This study was conducted to investigate the effect of a series of newly synthesized 1,4-dihydropyridines and pyridines, designed as potent P-glycoprotein inhibitors, on BCRP-mediated drug efflux both in vitro and in vivo.	Pyridines	95-104	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	169-173
16833728-0	2005	CH-stretching overtone spectra of a fast rotating methyl group: 2-CH3 and 2-CHD2 pyridines.	Pyridines	81-90	chromodomain helicase DNA binding protein 2	Homo sapiens	76-80
16158213-1	2005	PURPOSE: The aim of this study was to develop quantitative structure-activity/pharmacokinetic relationships (QSAR/QSPKR) for a series of synthesized 1,4-dihydropyridines (DHPs) and pyridines as P-glycoprotein (P-gp) inhibitors.	Pyridines	160-169	ATP binding cassette subfamily B member 1	Homo sapiens	194-208
16158213-1	2005	PURPOSE: The aim of this study was to develop quantitative structure-activity/pharmacokinetic relationships (QSAR/QSPKR) for a series of synthesized 1,4-dihydropyridines (DHPs) and pyridines as P-glycoprotein (P-gp) inhibitors.	Pyridines	160-169	ATP binding cassette subfamily B member 1	Homo sapiens	210-214
16158213-10	2005	CONCLUSION: QSAR/QSPKR models were developed, and the QSAR models were capable of identifying synthesized 1,4-DHPs and pyridines with potent P-gp inhibition and reduced Ca2+ channel binding.	Pyridines	119-128	ATP binding cassette subfamily B member 1	Homo sapiens	141-145
16136554-1	2005	The purpose of this study is to evaluate the effects of newly synthesized 4-aryl-1,4-dihydropyridine and pyridines on drug efflux mediated by multidrug resistance-associated protein 1 (MRP1, ABCC1).	Pyridines	105-114	ATP binding cassette subfamily C member 1	Homo sapiens	142-183
16136554-1	2005	The purpose of this study is to evaluate the effects of newly synthesized 4-aryl-1,4-dihydropyridine and pyridines on drug efflux mediated by multidrug resistance-associated protein 1 (MRP1, ABCC1).	Pyridines	105-114	ATP binding cassette subfamily C member 1	Homo sapiens	185-189
16136554-1	2005	The purpose of this study is to evaluate the effects of newly synthesized 4-aryl-1,4-dihydropyridine and pyridines on drug efflux mediated by multidrug resistance-associated protein 1 (MRP1, ABCC1).	Pyridines	105-114	ATP binding cassette subfamily C member 1	Homo sapiens	191-196
15728403-2	2005	N-methylated pyridines (e.g. MPP+) are well-established dopaminergic toxins, and the xenobiotic enzyme nicotinamide N-methyltransferase (NNMT) can convert pyridines such as 4-phenylpyridine into MPP+, using S-adenosyl methionine (SAM) as the methyl donor.	Pyridines	13-22	nicotinamide N-methyltransferase	Homo sapiens	137-141
15639403-3	2005	The enzyme nicotinamide N-methyltransferase (NNMT) can covert otherwise harmless pyridines such as 4-phenylpyridine into MPP+ like compounds.	Pyridines	81-90	nicotinamide N-methyltransferase	Homo sapiens	11-43
15639403-3	2005	The enzyme nicotinamide N-methyltransferase (NNMT) can covert otherwise harmless pyridines such as 4-phenylpyridine into MPP+ like compounds.	Pyridines	81-90	nicotinamide N-methyltransferase	Homo sapiens	45-49
15278168-1	2004	A complex of cobalt(II)(OCN)(2) coordinated with four pyridines having a stable tert-butyl aminoxyl exhibited in frozen MTHF a slow magnetic relaxation for the reorientation of magnetization with activation barrier, Delta/k(B) = 50 K, and a hysteresis loop having a fast relaxation at 0 Oe below 2.5 K.	Pyridines	54-63	bone gamma-carboxyglutamate protein	Homo sapiens	24-27
15339138-4	2004	The lowest energy electronic transition is sensitive to the electronegativity of the 4-substituent on the axial pyridines, varying from 516 nm for the CF3 group to 580 nm for the NMe2.	Pyridines	112-121	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	179-183
15287788-5	2004	The Brnsted-type plot (log kN vs pKa0 of the conjugate acids of the pyridines) for the reactions of thiolbenzoate 1 is curved with a slope at high pKa, beta1 = 0.20, and slope at low pKa0, beta2 = 0.94.	Pyridines	68-77	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	189-194
12565962-0	2003	Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors.	Pyridines	45-54	solute carrier family 6 member 3	Homo sapiens	64-84
12565962-3	2003	Simple substituted pyridines were discovered as novel dopamine transporter (DAT) inhibitors through pharmacophore-based 3D-database search.	Pyridines	19-28	solute carrier family 6 member 3	Homo sapiens	54-74
12565962-3	2003	Simple substituted pyridines were discovered as novel dopamine transporter (DAT) inhibitors through pharmacophore-based 3D-database search.	Pyridines	19-28	solute carrier family 6 member 3	Homo sapiens	76-79
12565962-6	2003	The substituted pyridines described herein represent a class of novel DAT inhibitors with simple chemical structures and their discovery provides additional insights into the binding site of DAT.	Pyridines	16-25	solute carrier family 6 member 3	Homo sapiens	70-73
12565962-6	2003	The substituted pyridines described herein represent a class of novel DAT inhibitors with simple chemical structures and their discovery provides additional insights into the binding site of DAT.	Pyridines	16-25	solute carrier family 6 member 3	Homo sapiens	191-194
12580498-9	2003	Substituted pyridines vary between 5.0 microg/cig.	Pyridines	12-21	fibronectin 1	Homo sapiens	46-49
10471062-1	1999	Nicotinamide N-methyltransferase (NNMT) catalyses the N-methylation of nicotinamide and structurally related pyridines.	Pyridines	109-118	nicotinamide N-methyltransferase	Homo sapiens	0-32
11354376-0	2001	Adamantylaminopyrimidines and -pyridines are potent inducers of tumor necrosis factor-alpha.	Pyridines	30-40	tumor necrosis factor	Homo sapiens	64-91
11154840-2	2001	Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions.	Pyridines	90-99	nicotinamide N-methyltransferase	Homo sapiens	0-32
11154840-2	2001	Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions.	Pyridines	90-99	nicotinamide N-methyltransferase	Homo sapiens	34-38
12396038-1	2002	[60]fullerene has been shown to form 1:1 molecular complexes with pyridine and some methylated pyridines such as 2-picoline, 3-picoline, 4-picoline, 2,6-lutidine and 2,4,6-collidine in CCl4 medium by absorption spectrometric method.	Pyridines	95-104	C-C motif chemokine ligand 4	Homo sapiens	185-189
10471062-1	1999	Nicotinamide N-methyltransferase (NNMT) catalyses the N-methylation of nicotinamide and structurally related pyridines.	Pyridines	109-118	nicotinamide N-methyltransferase	Homo sapiens	34-38
9714307-0	1998	Influence of some novel N-substituted azoles and pyridines on rat hepatic CYP3A activity.	Pyridines	49-58	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	74-79
9873497-0	1998	Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1).	Pyridines	31-40	endothelin converting enzyme 1	Homo sapiens	58-88
9873497-0	1998	Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1).	Pyridines	31-40	endothelin converting enzyme 1	Homo sapiens	90-95
8845860-1	1996	Nicotinamide N-methyltransferase (NNMT) catalyses the N-methylation of nicotinamide and other pyridines.	Pyridines	94-103	nicotinamide N-methyltransferase	Mus musculus	0-32
11672108-0	1998	Chiral Pyridines: Optical Resolution of 1-(2-Pyridyl)- and 1-[6-(2,2"-Bipyridyl)]ethanols by Lipase-Catalyzed Enantioselective Acetylation.	Pyridines	7-16	PAN0_003d1715	Moesziomyces antarcticus	93-99
8845860-1	1996	Nicotinamide N-methyltransferase (NNMT) catalyses the N-methylation of nicotinamide and other pyridines.	Pyridines	94-103	nicotinamide N-methyltransferase	Mus musculus	34-38
8182091-2	1994	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide and other pyridines.	Pyridines	94-103	nicotinamide N-methyltransferase	Homo sapiens	0-32
7954936-2	1994	Substituted pyridines were synthesized as potential angiotensin II (AII) receptor antagonists.	Pyridines	12-21	angiotensinogen	Homo sapiens	52-66
7954936-2	1994	Substituted pyridines were synthesized as potential angiotensin II (AII) receptor antagonists.	Pyridines	12-21	angiotensinogen	Homo sapiens	68-71
8182091-2	1994	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide and other pyridines.	Pyridines	94-103	nicotinamide N-methyltransferase	Homo sapiens	34-38
7510695-6	1994	In three cell types expressing CFTR, whole cell dialysis with reduced pyridine nucleotides inhibited activation of Cl- currents by forskolin and 8-(4-chlorophenylthio)-cAMP (CPT-cAMP), whereas dialysis with oxidized pyridines increased both basal and stimulated CFTR-mediated Cl- conductance.	Pyridines	216-225	CF transmembrane conductance regulator	Homo sapiens	31-35
34365903-5	2021	P6 (also known as Pyridines 6, EMD Chemicals), the Pan-JAK inhibitor, was used to inhibit the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway.	Pyridines	18-27	signal transducer and activator of transcription 3	Homo sapiens	163-168
8410980-2	1993	A series of pyridines and other six-membered ring heterocycles connected to a biphenyltetrazole with a -CH2-NR"-link (1) were discovered to be potent angiotensin II antagonists.	Pyridines	12-21	angiotensinogen	Rattus norvegicus	150-164
34931829-1	2022	A simple method for the synthesis of (E)-3-arylimino-3H-indolizin-4-ium-1-olates by an iodate-promoted multicomponent reaction between 3,3-difluorocyclopropenes, pyridines, and anilines was discovered.	Pyridines	162-171	small nucleolar RNA, H/ACA box 63	Homo sapiens	37-42
34190562-1	2021	Ni(COD)2-catalyzed cycloaddition reactions to access pyridines have been extensively studied.	Pyridines	53-62	COD2	Homo sapiens	0-8
34546730-1	2021	Two C C bond participation in annulation to pyridines using N,N-dimethylformamide (DMF) as the N1 and C4 synthons has been carried out.	Pyridines	44-53	complement C4A (Rodgers blood group)	Homo sapiens	95-104
34205151-1	2021	Reactions between Zn(II) dihalides and 2-halogen-substituted pyridines 2-XPy result in a series of heteroleptic molecular complexes ((2-XPy)2ZnY2) (Y = Cl, X = Cl (1), Br (2), I (3); Y = Br, X = Cl (4), Br (5), I (6), Y = I, X = Cl (7), Br (8), and I (9)).	Pyridines	61-70	chromosome 12 open reading frame 73	Homo sapiens	168-170
34204215-8	2021	The prepared CS/La2O3 nanocomposite film (15% by weight) was investigated as an effective, recyclable, and heterogeneous base catalyst in the synthesis of pyridines and pyrazoles.	Pyridines	155-164	citrate synthase	Homo sapiens	13-15
34205151-1	2021	Reactions between Zn(II) dihalides and 2-halogen-substituted pyridines 2-XPy result in a series of heteroleptic molecular complexes ((2-XPy)2ZnY2) (Y = Cl, X = Cl (1), Br (2), I (3); Y = Br, X = Cl (4), Br (5), I (6), Y = I, X = Cl (7), Br (8), and I (9)).	Pyridines	61-70	chromosome 12 open reading frame 73	Homo sapiens	187-189
34205151-1	2021	Reactions between Zn(II) dihalides and 2-halogen-substituted pyridines 2-XPy result in a series of heteroleptic molecular complexes ((2-XPy)2ZnY2) (Y = Cl, X = Cl (1), Br (2), I (3); Y = Br, X = Cl (4), Br (5), I (6), Y = I, X = Cl (7), Br (8), and I (9)).	Pyridines	61-70	chromosome 12 open reading frame 73	Homo sapiens	203-205
34205151-1	2021	Reactions between Zn(II) dihalides and 2-halogen-substituted pyridines 2-XPy result in a series of heteroleptic molecular complexes ((2-XPy)2ZnY2) (Y = Cl, X = Cl (1), Br (2), I (3); Y = Br, X = Cl (4), Br (5), I (6), Y = I, X = Cl (7), Br (8), and I (9)).	Pyridines	61-70	chromosome 12 open reading frame 73	Homo sapiens	237-239
35198877-7	2022	Finally, we identify regulation by free pyridines, NADP, and nicotinic acid riboside (NaR) on SARM1, all of therapeutic interest.	Pyridines	40-49	sterile alpha and TIR motif containing 1	Homo sapiens	94-99
35362233-2	2022	Ab initio calculation at the MP2/aug-cc-pVTZ level has been performed on the pi-hole based N ... Si tetrel bonded complexes between substituted pyridines and H 2 SiO.	Pyridines	144-153	tryptase pseudogene 1	Homo sapiens	29-32