PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16966031-10	2006	Pretreatment of mice with the PPAR-gamma agonists 15-deoxy-Delta12, 14-prostaglandin J(2), or troglitazone significantly reduced the severity of pancreatitis in a dose-dependent manner.	14-prostaglandin j	68-86	peroxisome proliferator activated receptor gamma	Mus musculus	30-40
22387200-2	2012	Because 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) is an electrophilic prostaglandin that can increase glutathione (GSH) levels and augment reactive oxygen species (ROS) production, we hypothesized that it induces NF-kappaB-p65 glutathionylation and would exert anti-inflammatory effects.	14-prostaglandin j	25-43	RELA proto-oncogene, NF-kB subunit	Homo sapiens	233-236
21307572-5	2011	The disassociation constants (Kd) of the PPARgamma synthesized ligands, pioglitazone (221 nM), troglitazone (83.0 nM), and 15-deoxy-Delta12,14-prostaglandin J(2) (15d-DeltaPGJ(2)) (156 nM), were determined by this method.	14-prostaglandin j	140-158	peroxisome proliferator activated receptor gamma	Homo sapiens	41-50
19701967-6	2009	The PPAR-gamma agonist 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) inhibited growth, and induced apoptosis and G(1)/G(0) cell cycle arrest in MGC803 cells in a concentration-dependent and time-dependent manner.	14-prostaglandin j	40-58	peroxisome proliferator activated receptor gamma	Homo sapiens	4-14
16723090-2	2006	METHODS: After being treated with various amounts of the PPAR gamma natural ligand 15-deoxy-delta12,14-prostaglandin J(2) (15-d-PGJ(2)) or synthetic ligand GW7845, the status of HSC proliferation and apoptosis were detected by MTT assay and flow cytometry.	14-prostaglandin j	100-118	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	57-67
16299251-5	2005	RESULTS: The cyclopentenone prostaglandin, 15-deoxy-Delta12,14-prostaglandin J(2), a known inhibitor of NF-kappaB, induced caspase-dependent apoptosis; it restored mitochondrial apoptotic signaling by down-regulation of X-linked inhibitor of apoptosis protein and heat shock protein 27 and led to breakdown of the mitochondrial membrane potential and, finally, cleavage of caspase-3 irrespective of IkappaBalpha mutational status.	14-prostaglandin j	60-78	nuclear factor kappa B subunit 1	Homo sapiens	104-113
16299251-5	2005	RESULTS: The cyclopentenone prostaglandin, 15-deoxy-Delta12,14-prostaglandin J(2), a known inhibitor of NF-kappaB, induced caspase-dependent apoptosis; it restored mitochondrial apoptotic signaling by down-regulation of X-linked inhibitor of apoptosis protein and heat shock protein 27 and led to breakdown of the mitochondrial membrane potential and, finally, cleavage of caspase-3 irrespective of IkappaBalpha mutational status.	14-prostaglandin j	60-78	caspase 3	Homo sapiens	373-382
16299251-5	2005	RESULTS: The cyclopentenone prostaglandin, 15-deoxy-Delta12,14-prostaglandin J(2), a known inhibitor of NF-kappaB, induced caspase-dependent apoptosis; it restored mitochondrial apoptotic signaling by down-regulation of X-linked inhibitor of apoptosis protein and heat shock protein 27 and led to breakdown of the mitochondrial membrane potential and, finally, cleavage of caspase-3 irrespective of IkappaBalpha mutational status.	14-prostaglandin j	60-78	NFKB inhibitor alpha	Homo sapiens	399-411
16299251-6	2005	Surprisingly, 15-deoxy-Delta12,14-prostaglandin J(2) and the IkappaB kinase inhibitor curcumin both reduced nuclear levels of p65 in cell lines lacking IkappaBalpha, suggesting that inhibition of nuclear translocation of NF-kappaB can occur in the absence of IkappaBalpha.	14-prostaglandin j	31-49	RELA proto-oncogene, NF-kB subunit	Homo sapiens	126-129
16299251-6	2005	Surprisingly, 15-deoxy-Delta12,14-prostaglandin J(2) and the IkappaB kinase inhibitor curcumin both reduced nuclear levels of p65 in cell lines lacking IkappaBalpha, suggesting that inhibition of nuclear translocation of NF-kappaB can occur in the absence of IkappaBalpha.	14-prostaglandin j	31-49	NFKB inhibitor alpha	Homo sapiens	152-164
16299251-6	2005	Surprisingly, 15-deoxy-Delta12,14-prostaglandin J(2) and the IkappaB kinase inhibitor curcumin both reduced nuclear levels of p65 in cell lines lacking IkappaBalpha, suggesting that inhibition of nuclear translocation of NF-kappaB can occur in the absence of IkappaBalpha.	14-prostaglandin j	31-49	nuclear factor kappa B subunit 1	Homo sapiens	221-230
16299251-6	2005	Surprisingly, 15-deoxy-Delta12,14-prostaglandin J(2) and the IkappaB kinase inhibitor curcumin both reduced nuclear levels of p65 in cell lines lacking IkappaBalpha, suggesting that inhibition of nuclear translocation of NF-kappaB can occur in the absence of IkappaBalpha.	14-prostaglandin j	31-49	NFKB inhibitor alpha	Homo sapiens	259-271
12829999-6	2003	Exposure of SG231, CC-LP-1, and HuCCT1 cells to PPARgamma ligands 15-deoxy-delta12, 14-prostaglandin J(2) (15d-PGJ(2)) and troglitazone for 24 to 96 hours resulted in a dose-dependent inhibition of cell growth.	14-prostaglandin j	84-102	peroxisome proliferator activated receptor gamma	Homo sapiens	48-57
11554760-3	2001	The endogenous and exogenous PPAR-gamma ligands 15-deoxy-d12,14-prostaglandin J(2) (15-PGJ(2)) and ciglitazone decreased cell number, cell viability, and increased floating/attached ratio, in a time- and dose-dependent fashion.	14-prostaglandin j	61-79	peroxisome proliferator activated receptor gamma	Homo sapiens	29-39
10944516-4	2000	The natural ligand 15-deoxy-Delta12,14-prostaglandin J(2) induced PPARgamma interactions with all coactivators tested (SRC-1, TIF2, AIB-1, p300, TRAP220/DRIP205) in yeast and mammalian two-hybrid assays, as well as in a glutathione S-transferase pull-down assay.	14-prostaglandin j	36-54	peroxisome proliferator activated receptor gamma	Homo sapiens	66-75
10944516-4	2000	The natural ligand 15-deoxy-Delta12,14-prostaglandin J(2) induced PPARgamma interactions with all coactivators tested (SRC-1, TIF2, AIB-1, p300, TRAP220/DRIP205) in yeast and mammalian two-hybrid assays, as well as in a glutathione S-transferase pull-down assay.	14-prostaglandin j	36-54	Src1p	Saccharomyces cerevisiae S288C	119-124
10944516-4	2000	The natural ligand 15-deoxy-Delta12,14-prostaglandin J(2) induced PPARgamma interactions with all coactivators tested (SRC-1, TIF2, AIB-1, p300, TRAP220/DRIP205) in yeast and mammalian two-hybrid assays, as well as in a glutathione S-transferase pull-down assay.	14-prostaglandin j	36-54	translation initiation factor eIF4A	Saccharomyces cerevisiae S288C	126-130
10944516-4	2000	The natural ligand 15-deoxy-Delta12,14-prostaglandin J(2) induced PPARgamma interactions with all coactivators tested (SRC-1, TIF2, AIB-1, p300, TRAP220/DRIP205) in yeast and mammalian two-hybrid assays, as well as in a glutathione S-transferase pull-down assay.	14-prostaglandin j	36-54	ANIB1	Homo sapiens	132-137
10944516-4	2000	The natural ligand 15-deoxy-Delta12,14-prostaglandin J(2) induced PPARgamma interactions with all coactivators tested (SRC-1, TIF2, AIB-1, p300, TRAP220/DRIP205) in yeast and mammalian two-hybrid assays, as well as in a glutathione S-transferase pull-down assay.	14-prostaglandin j	36-54	mediator complex subunit 1	Homo sapiens	145-152
10944516-4	2000	The natural ligand 15-deoxy-Delta12,14-prostaglandin J(2) induced PPARgamma interactions with all coactivators tested (SRC-1, TIF2, AIB-1, p300, TRAP220/DRIP205) in yeast and mammalian two-hybrid assays, as well as in a glutathione S-transferase pull-down assay.	14-prostaglandin j	36-54	mediator complex subunit 1	Homo sapiens	153-160
15720836-0	2004	A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats.	14-prostaglandin j	38-56	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	2-12
12584205-4	2003	We show that 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) and rosiglitazone reduce the phosphorylation of STAT1 and STAT3 as well as Janus kinase 1 (JAK1) and JAK2 in activated astrocytes and microglia.	14-prostaglandin j	30-48	signal transducer and activator of transcription 1	Homo sapiens	113-118
12584205-4	2003	We show that 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) and rosiglitazone reduce the phosphorylation of STAT1 and STAT3 as well as Janus kinase 1 (JAK1) and JAK2 in activated astrocytes and microglia.	14-prostaglandin j	30-48	signal transducer and activator of transcription 3	Homo sapiens	123-128
12584205-4	2003	We show that 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) and rosiglitazone reduce the phosphorylation of STAT1 and STAT3 as well as Janus kinase 1 (JAK1) and JAK2 in activated astrocytes and microglia.	14-prostaglandin j	30-48	Janus kinase 1	Homo sapiens	140-154
12584205-4	2003	We show that 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) and rosiglitazone reduce the phosphorylation of STAT1 and STAT3 as well as Janus kinase 1 (JAK1) and JAK2 in activated astrocytes and microglia.	14-prostaglandin j	30-48	Janus kinase 1	Homo sapiens	156-160
12584205-4	2003	We show that 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) and rosiglitazone reduce the phosphorylation of STAT1 and STAT3 as well as Janus kinase 1 (JAK1) and JAK2 in activated astrocytes and microglia.	14-prostaglandin j	30-48	Janus kinase 2	Homo sapiens	166-170
10506103-4	1999	Activation of PPARgamma with the known prostanoid agonist 15-deoxy-Delta12,14-prostaglandin J(2) (15dPGJ(2)) or the thiazolidinedione (TZD) agonist troglitazone (TGZ) attenuated cellular proliferation of the estrogen receptor-negative breast cancer cell line MDA-MB-231, as well as the estrogen receptor-positive breast cancer cell line MCF-7.	14-prostaglandin j	75-93	peroxisome proliferator activated receptor gamma	Homo sapiens	14-23