PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27052460-9	2017	Liquid chromatography and mass spectrometry indicated that the levels of 22-hydroxycholesterol, 25-hydroxycholesterol, and 24,25-epoxycholesterol were higher in the DDC-injured livers of SULT2B1-/- mice than in livers of WT mice.	24,25-epoxycholesterol	123-145	sulfotransferase family, cytosolic, 2B, member 1	Mus musculus	187-194
33636107-5	2021	Increasing flux through the epoxycholesterol shunt using genetic manipulation or small-molecule inhibition of lanosterol synthase (LSS) increased endogenous 24,25-epoxycholesterol levels and OPC differentiation.	24,25-epoxycholesterol	157-179	lanosterol synthase	Homo sapiens	110-129
33636107-5	2021	Increasing flux through the epoxycholesterol shunt using genetic manipulation or small-molecule inhibition of lanosterol synthase (LSS) increased endogenous 24,25-epoxycholesterol levels and OPC differentiation.	24,25-epoxycholesterol	157-179	lanosterol synthase	Homo sapiens	131-134
31168089-3	2019	Here we show that 24,25-epoxycholesterol, which we identify as an endogenous ligand of PTCH1, can stimulate Hedgehog signalling in cells and can trigger G-protein signalling via human SMO in vitro.	24,25-epoxycholesterol	18-40	patched 1	Homo sapiens	87-92
31168089-3	2019	Here we show that 24,25-epoxycholesterol, which we identify as an endogenous ligand of PTCH1, can stimulate Hedgehog signalling in cells and can trigger G-protein signalling via human SMO in vitro.	24,25-epoxycholesterol	18-40	smoothened, frizzled class receptor	Homo sapiens	184-187
30655290-2	2019	We found previously that 24(S),25-epoxycholesterol (24,25-EC), the most potent and abundant Lxr ligand in the developing mouse midbrain, promotes mDA neurogenesis in vitro In this study, we demonstrate that 24,25-EC promotes mDA neurogenesis in an Lxr-dependent manner in the developing mouse midbrain in vivo and also prevents toxicity induced by the Lxr inhibitor geranylgeranyl pyrophosphate.	24,25-epoxycholesterol	52-60	nuclear receptor subfamily 1, group H, member 3	Mus musculus	92-95
30655290-2	2019	We found previously that 24(S),25-epoxycholesterol (24,25-EC), the most potent and abundant Lxr ligand in the developing mouse midbrain, promotes mDA neurogenesis in vitro In this study, we demonstrate that 24,25-EC promotes mDA neurogenesis in an Lxr-dependent manner in the developing mouse midbrain in vivo and also prevents toxicity induced by the Lxr inhibitor geranylgeranyl pyrophosphate.	24,25-epoxycholesterol	52-60	nuclear receptor subfamily 1, group H, member 3	Mus musculus	248-251
30655290-2	2019	We found previously that 24(S),25-epoxycholesterol (24,25-EC), the most potent and abundant Lxr ligand in the developing mouse midbrain, promotes mDA neurogenesis in vitro In this study, we demonstrate that 24,25-EC promotes mDA neurogenesis in an Lxr-dependent manner in the developing mouse midbrain in vivo and also prevents toxicity induced by the Lxr inhibitor geranylgeranyl pyrophosphate.	24,25-epoxycholesterol	52-60	nuclear receptor subfamily 1, group H, member 3	Mus musculus	248-251
30655290-2	2019	We found previously that 24(S),25-epoxycholesterol (24,25-EC), the most potent and abundant Lxr ligand in the developing mouse midbrain, promotes mDA neurogenesis in vitro In this study, we demonstrate that 24,25-EC promotes mDA neurogenesis in an Lxr-dependent manner in the developing mouse midbrain in vivo and also prevents toxicity induced by the Lxr inhibitor geranylgeranyl pyrophosphate.	24,25-epoxycholesterol	207-215	nuclear receptor subfamily 1, group H, member 3	Mus musculus	248-251
30655290-2	2019	We found previously that 24(S),25-epoxycholesterol (24,25-EC), the most potent and abundant Lxr ligand in the developing mouse midbrain, promotes mDA neurogenesis in vitro In this study, we demonstrate that 24,25-EC promotes mDA neurogenesis in an Lxr-dependent manner in the developing mouse midbrain in vivo and also prevents toxicity induced by the Lxr inhibitor geranylgeranyl pyrophosphate.	24,25-epoxycholesterol	207-215	nuclear receptor subfamily 1, group H, member 3	Mus musculus	248-251
24491562-6	2014	However, the level of the cholesterol precursor, desomsterol, and its parallel metabolite formed via a shut of the mevalonate pathway, 24S,25-epoxycholesterol, were reduced in the Cyp46a1-/- mouse.	24,25-epoxycholesterol	135-158	cytochrome P450, family 46, subfamily a, polypeptide 1	Mus musculus	180-187
26698156-5	2016	Treatment of CEM and CEM/R2 cells with cholesterol biosynthesis inhibitors acting on the enzymes squalene epoxidase and lanosterol synthase, both also involved in the 24,25-epoxycholesterol shunt pathway, revealed a connection of this pathway to lanosterol turnover.	24,25-epoxycholesterol	167-189	lanosterol synthase	Homo sapiens	120-139
16901265-9	2006	Moreover, ABCA1 gene expression was positively associated with synthesis of 24(S),25-epoxycholesterol in these cell lines.	24,25-epoxycholesterol	76-101	ATP binding cassette subfamily A member 1	Homo sapiens	10-15
17825266-1	2007	The liver X receptor (LXR) agonists, 24(S),25-epoxycholesterol and T0901317, were previously shown to be capable of inducing CYP3A expression in primary cultured rodent hepatocytes through activation of the pregnane X receptor (PXR).	24,25-epoxycholesterol	37-62	nuclear receptor subfamily 1 group I member 2	Homo sapiens	207-226
17825266-1	2007	The liver X receptor (LXR) agonists, 24(S),25-epoxycholesterol and T0901317, were previously shown to be capable of inducing CYP3A expression in primary cultured rodent hepatocytes through activation of the pregnane X receptor (PXR).	24,25-epoxycholesterol	37-62	nuclear receptor subfamily 1 group I member 2	Homo sapiens	228-231
17954216-8	2007	Cultured RAW 264.7 mouse macrophages contain many different sterols, including the liver X receptor (LXR) ligand 24,25-epoxycholesterol.	24,25-epoxycholesterol	113-135	nuclear receptor subfamily 1, group H, member 3	Mus musculus	83-99
17954216-8	2007	Cultured RAW 264.7 mouse macrophages contain many different sterols, including the liver X receptor (LXR) ligand 24,25-epoxycholesterol.	24,25-epoxycholesterol	113-135	nuclear receptor subfamily 1, group H, member 3	Mus musculus	101-104
23292650-4	2013	Moreover, 24(S),25-epoxycholesterol (24,25-EC) was found to be the most potent and abundant Lxr ligand in the developing mouse midbrain.	24,25-epoxycholesterol	10-35	nuclear receptor subfamily 1, group H, member 3	Mus musculus	92-95
23292650-4	2013	Moreover, 24(S),25-epoxycholesterol (24,25-EC) was found to be the most potent and abundant Lxr ligand in the developing mouse midbrain.	24,25-epoxycholesterol	37-45	nuclear receptor subfamily 1, group H, member 3	Mus musculus	92-95
23292650-9	2013	Moreover, 24,25-EC promoted dopaminergic differentiation of embryonic stem cells, suggesting that Lxr ligands may thus contribute to the development of cell replacement and regenerative therapies for Parkinson"s disease.	24,25-epoxycholesterol	10-18	nuclear receptor subfamily 1, group H, member 3	Mus musculus	98-101
14709622-3	2004	The effects of 24(S),25-epoxycholesterol on CYP3A content were much greater than were those of 25-hydroxycholesterol, consistent with the relative abilities of these sterols to bind and activate LXR.	24,25-epoxycholesterol	15-40	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	44-49
15951028-3	2005	OSC also catalyzes the formation of 24(S),25-epoxycholesterol, a ligand activator of the liver X receptor.	24,25-epoxycholesterol	36-61	lanosterol synthase	Homo sapiens	0-3
14709622-3	2004	The effects of 24(S),25-epoxycholesterol on CYP3A content were much greater than were those of 25-hydroxycholesterol, consistent with the relative abilities of these sterols to bind and activate LXR.	24,25-epoxycholesterol	15-40	nuclear receptor subfamily 1, group H, member 3	Mus musculus	195-198
14709622-5	2004	CYP3A mRNA levels were increased after treatment with 24(S),25-epoxycholesterol in both wild-type and LXR-null mouse hepatocytes.	24,25-epoxycholesterol	54-79	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	0-5
14709622-5	2004	CYP3A mRNA levels were increased after treatment with 24(S),25-epoxycholesterol in both wild-type and LXR-null mouse hepatocytes.	24,25-epoxycholesterol	54-79	nuclear receptor subfamily 1, group H, member 3	Mus musculus	102-105
8043030-4	1994	The accumulation of 24,25-epoxycholesterol in relationship to the decrease of C27-sterol biosynthesis and of HMG-CoA reductase activity showed only a partial correlation: e.g. at [1] = 100 x IC50 only a 50% reduction in enzyme activity could be attained.	24,25-epoxycholesterol	20-42	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	109-126
8043030-5	1994	In contrast, when HepG2 cells were treated with 2,3:22,23-dioxidosqualene or 24,25-epoxycholesterol, excellent correlations were found between the inhibition of C27-sterol biosynthesis and the repression of HMG-CoA reductase activity, which was almost complete at the highest concentrations of these epoxides (10(-5) M).	24,25-epoxycholesterol	77-99	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	207-224