PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33351272-10 2021 Purification of hydroxytyrosol was tentatively confirmed on a C18 TDE column with 1.6% sample loading, 90.98% recovery, and 98.01% purity. 3,4-dihydroxyphenylethanol 16-30 Bardet-Biedl syndrome 9 Homo sapiens 62-65 2432930-2 1986 The individual, homogeneous class I isozymes oxidize (3,4-dihydroxyphenyl)ethanol and (4-hydroxy-3-methoxyphenyl)ethanol (HMPE) and ethanol with kcat/Km values in the range from 16 to 240 mM-1 min-1 and from 16 to 66 mM-1 min-1, respectively. 3,4-dihydroxyphenylethanol 53-81 CD59 molecule (CD59 blood group) Homo sapiens 193-198 2432930-2 1986 The individual, homogeneous class I isozymes oxidize (3,4-dihydroxyphenyl)ethanol and (4-hydroxy-3-methoxyphenyl)ethanol (HMPE) and ethanol with kcat/Km values in the range from 16 to 240 mM-1 min-1 and from 16 to 66 mM-1 min-1, respectively. 3,4-dihydroxyphenylethanol 53-81 CD59 molecule (CD59 blood group) Homo sapiens 222-227 33998633-9 2021 HT administration significantly suppressed microglia activation and inhibited the expression of tumor necrosis factor alpha and interleukin 1 beta in the hippocampus versus the untreated group. 3,4-dihydroxyphenylethanol 0-2 tumor necrosis factor Mus musculus 96-123 33998633-9 2021 HT administration significantly suppressed microglia activation and inhibited the expression of tumor necrosis factor alpha and interleukin 1 beta in the hippocampus versus the untreated group. 3,4-dihydroxyphenylethanol 0-2 interleukin 1 beta Mus musculus 128-146 33998633-11 2021 Furthermore, HT treatment increased the expression of hippocampal brain-derived neurotrophic factor (BDNF), phosphorylated tropomyosin receptor kinase B (p-TrkB), and phosphorylated c-AMP response element binding protein (p-CREB) compared with the untreated CUMS group. 3,4-dihydroxyphenylethanol 13-15 brain derived neurotrophic factor Mus musculus 66-99 33998633-11 2021 Furthermore, HT treatment increased the expression of hippocampal brain-derived neurotrophic factor (BDNF), phosphorylated tropomyosin receptor kinase B (p-TrkB), and phosphorylated c-AMP response element binding protein (p-CREB) compared with the untreated CUMS group. 3,4-dihydroxyphenylethanol 13-15 brain derived neurotrophic factor Mus musculus 101-105 33998633-11 2021 Furthermore, HT treatment increased the expression of hippocampal brain-derived neurotrophic factor (BDNF), phosphorylated tropomyosin receptor kinase B (p-TrkB), and phosphorylated c-AMP response element binding protein (p-CREB) compared with the untreated CUMS group. 3,4-dihydroxyphenylethanol 13-15 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 156-160 33998633-11 2021 Furthermore, HT treatment increased the expression of hippocampal brain-derived neurotrophic factor (BDNF), phosphorylated tropomyosin receptor kinase B (p-TrkB), and phosphorylated c-AMP response element binding protein (p-CREB) compared with the untreated CUMS group. 3,4-dihydroxyphenylethanol 13-15 cAMP responsive element binding protein 1 Mus musculus 224-228 33687886-7 2022 Also, nano-capsulated hydroxytyrosol showed more significant effects on the up-regulation of CDKN1A and CDKN1B genes, and down-regulation of the CCND1 gene in the colorectal cancer cells. 3,4-dihydroxyphenylethanol 22-36 cyclin dependent kinase inhibitor 1A Homo sapiens 93-99 33687886-7 2022 Also, nano-capsulated hydroxytyrosol showed more significant effects on the up-regulation of CDKN1A and CDKN1B genes, and down-regulation of the CCND1 gene in the colorectal cancer cells. 3,4-dihydroxyphenylethanol 22-36 cyclin dependent kinase inhibitor 1B Homo sapiens 104-110 33687886-7 2022 Also, nano-capsulated hydroxytyrosol showed more significant effects on the up-regulation of CDKN1A and CDKN1B genes, and down-regulation of the CCND1 gene in the colorectal cancer cells. 3,4-dihydroxyphenylethanol 22-36 cyclin D1 Homo sapiens 145-150 33540713-5 2021 The evaluation of the mechanism of action suggested that both HIDROX and HT induced structural changes in SARS-CoV-2, which changed the molecular weight of the spike proteins. 3,4-dihydroxyphenylethanol 73-75 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 160-165 33546278-5 2021 Hydroxytyrosol, tyrosol, and apigenin augmented beta-cell proliferation and insulin biosynthesis, and apigenin and luteolin enhanced the GSIS. 3,4-dihydroxyphenylethanol 0-14 insulin Homo sapiens 76-83 32840384-6 2021 Treatment with HT inhibited the incidence of oxidative damage in splenic tissue through decreasing lipoperoxidation and increasing antioxidant molecules, namely glutathione, superoxide dismutase and catalase. 3,4-dihydroxyphenylethanol 15-17 catalase Mus musculus 199-207 33336758-0 2020 Hydroxytyrosol inhibits apoptosis in ischemia/reperfusion-induced acute kidney injury via activating Sonic Hedgehog signaling pathway. 3,4-dihydroxyphenylethanol 0-14 sonic hedgehog signaling molecule Homo sapiens 101-115 32542704-0 2021 Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats. 3,4-dihydroxyphenylethanol 0-14 solute carrier family 2 member 4 Rattus norvegicus 40-45 32542704-0 2021 Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats. 3,4-dihydroxyphenylethanol 0-14 AKT serine/threonine kinase 1 Rattus norvegicus 46-49 32542704-0 2021 Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats. 3,4-dihydroxyphenylethanol 0-14 Rac family small GTPase 1 Rattus norvegicus 50-54 33390115-7 2020 Also, free and nano-encapsulated hydroxytyrosol increased the expression of P21 and P27 genes and reduced the expression of Cyclin D1 in breast cancer cells. 3,4-dihydroxyphenylethanol 33-47 cyclin dependent kinase inhibitor 1A Homo sapiens 76-79 33390115-7 2020 Also, free and nano-encapsulated hydroxytyrosol increased the expression of P21 and P27 genes and reduced the expression of Cyclin D1 in breast cancer cells. 3,4-dihydroxyphenylethanol 33-47 dynactin subunit 6 Homo sapiens 84-87 33390115-7 2020 Also, free and nano-encapsulated hydroxytyrosol increased the expression of P21 and P27 genes and reduced the expression of Cyclin D1 in breast cancer cells. 3,4-dihydroxyphenylethanol 33-47 cyclin D1 Homo sapiens 124-133 32781170-0 2020 Hydroxytyrosol enhances cisplatin-induced ototoxicity: Possible relation to the alteration in the activity of JNK and AIF pathways. 3,4-dihydroxyphenylethanol 0-14 mitogen-activated protein kinase 8 Homo sapiens 110-113 32781170-0 2020 Hydroxytyrosol enhances cisplatin-induced ototoxicity: Possible relation to the alteration in the activity of JNK and AIF pathways. 3,4-dihydroxyphenylethanol 0-14 apoptosis inducing factor mitochondria associated 1 Homo sapiens 118-121 33096799-6 2020 Generally speaking, oleuropein and hydroxytyrosol contents enhanced with the application of 200 mg mL-1 of salicylic acid. 3,4-dihydroxyphenylethanol 35-49 L1 cell adhesion molecule Mus musculus 99-103 33170176-11 2020 In addition, we identified possible interactions among hydroxytyrosol and alpha-cyclodextrin with the protein Spike and the human proteins ACE2 and TMPRSS2. 3,4-dihydroxyphenylethanol 55-69 angiotensin converting enzyme 2 Homo sapiens 139-143 33170176-11 2020 In addition, we identified possible interactions among hydroxytyrosol and alpha-cyclodextrin with the protein Spike and the human proteins ACE2 and TMPRSS2. 3,4-dihydroxyphenylethanol 55-69 transmembrane serine protease 2 Homo sapiens 148-155 33137997-4 2020 Moreover, we showed that the hydroxytyrosol treatment of melanoma cells leads to a significant increase of p53 and gammaH2AX expression, a significant decrease of AKT expression and the inhibition of cell colony formation ability. 3,4-dihydroxyphenylethanol 29-43 tumor protein p53 Homo sapiens 107-110 33137997-4 2020 Moreover, we showed that the hydroxytyrosol treatment of melanoma cells leads to a significant increase of p53 and gammaH2AX expression, a significant decrease of AKT expression and the inhibition of cell colony formation ability. 3,4-dihydroxyphenylethanol 29-43 AKT serine/threonine kinase 1 Homo sapiens 163-166 33060043-2 2021 We recently reported that Hydroxytyrosol (HXT) and Vitamin E (VitE) may improve oxidative stress, insulin resistance, and steatosis in children with biopsy-proven NAFLD. 3,4-dihydroxyphenylethanol 26-40 insulin Homo sapiens 98-105 32943925-3 2020 In this study, the effect of hydroxytyrosol on the expression of genes effective in apoptosis - BAX, BCL2, CASP3, P53, PPAR G, and NFE2L2 - and antioxidant-enzyme activity in LS180 cells of human colorectal cancer was investigated. 3,4-dihydroxyphenylethanol 29-43 BCL2 associated X, apoptosis regulator Homo sapiens 96-99 32943925-3 2020 In this study, the effect of hydroxytyrosol on the expression of genes effective in apoptosis - BAX, BCL2, CASP3, P53, PPAR G, and NFE2L2 - and antioxidant-enzyme activity in LS180 cells of human colorectal cancer was investigated. 3,4-dihydroxyphenylethanol 29-43 BCL2 apoptosis regulator Homo sapiens 101-105 32943925-3 2020 In this study, the effect of hydroxytyrosol on the expression of genes effective in apoptosis - BAX, BCL2, CASP3, P53, PPAR G, and NFE2L2 - and antioxidant-enzyme activity in LS180 cells of human colorectal cancer was investigated. 3,4-dihydroxyphenylethanol 29-43 caspase 3 Homo sapiens 107-112 32943925-3 2020 In this study, the effect of hydroxytyrosol on the expression of genes effective in apoptosis - BAX, BCL2, CASP3, P53, PPAR G, and NFE2L2 - and antioxidant-enzyme activity in LS180 cells of human colorectal cancer was investigated. 3,4-dihydroxyphenylethanol 29-43 tumor protein p53 Homo sapiens 114-117 32943925-3 2020 In this study, the effect of hydroxytyrosol on the expression of genes effective in apoptosis - BAX, BCL2, CASP3, P53, PPAR G, and NFE2L2 - and antioxidant-enzyme activity in LS180 cells of human colorectal cancer was investigated. 3,4-dihydroxyphenylethanol 29-43 peroxisome proliferator activated receptor gamma Homo sapiens 119-125 32943925-3 2020 In this study, the effect of hydroxytyrosol on the expression of genes effective in apoptosis - BAX, BCL2, CASP3, P53, PPAR G, and NFE2L2 - and antioxidant-enzyme activity in LS180 cells of human colorectal cancer was investigated. 3,4-dihydroxyphenylethanol 29-43 NFE2 like bZIP transcription factor 2 Homo sapiens 131-137 32943925-7 2020 Results: Analysis of gene expression showed that hydroxytyrosol significantly increased the expression of CASP3 and the BAX:BCL2 ratio in treatment groups compared to the control (P<0.05). 3,4-dihydroxyphenylethanol 49-63 caspase 3 Homo sapiens 106-111 32943925-7 2020 Results: Analysis of gene expression showed that hydroxytyrosol significantly increased the expression of CASP3 and the BAX:BCL2 ratio in treatment groups compared to the control (P<0.05). 3,4-dihydroxyphenylethanol 49-63 BCL2 associated X, apoptosis regulator Homo sapiens 120-123 32943925-7 2020 Results: Analysis of gene expression showed that hydroxytyrosol significantly increased the expression of CASP3 and the BAX:BCL2 ratio in treatment groups compared to the control (P<0.05). 3,4-dihydroxyphenylethanol 49-63 BCL2 apoptosis regulator Homo sapiens 124-128 32943925-8 2020 Also, hydroxytyrosol significantly reduced the expression of the NFE2L2 gene (P<0.05). 3,4-dihydroxyphenylethanol 6-20 NFE2 like bZIP transcription factor 2 Homo sapiens 65-71 32943925-9 2020 Calorimetric analysis showed that hydroxytyrosol increased activity of the antioxidant enzymes catalase, superoxide dismutase, and glutathione peroxidase in treatment groups significantly more than the control group and reduced thiobarbituric acid-reactive substances on an oxidative stress index (P<0.05). 3,4-dihydroxyphenylethanol 34-48 catalase Homo sapiens 95-103 32943925-10 2020 Conclusion: Hydroxytyrosol may induce apoptosis in colorectal cancer cells by increasing the expression of CASP3 gene and increasing the BAX:BCL2 ratio. 3,4-dihydroxyphenylethanol 12-26 caspase 3 Homo sapiens 107-112 32943925-10 2020 Conclusion: Hydroxytyrosol may induce apoptosis in colorectal cancer cells by increasing the expression of CASP3 gene and increasing the BAX:BCL2 ratio. 3,4-dihydroxyphenylethanol 12-26 BCL2 associated X, apoptosis regulator Homo sapiens 137-140 32943925-10 2020 Conclusion: Hydroxytyrosol may induce apoptosis in colorectal cancer cells by increasing the expression of CASP3 gene and increasing the BAX:BCL2 ratio. 3,4-dihydroxyphenylethanol 12-26 BCL2 apoptosis regulator Homo sapiens 141-145 32527456-6 2020 Moreover, HT-ONO2 shown definite vasodilation and alpha-glucosidase inhibition activity in vitro. 3,4-dihydroxyphenylethanol 10-12 sucrase isomaltase (alpha-glucosidase) Mus musculus 50-67 32756342-5 2020 RESULTS: Our results showed that hydroxytyrosol (10 and 25 muM) was able to prevent the oxidative stress induced by LPS (intracellular ROS, GSH and NOX-1) and the consequently inflammatory response (TNF-alpha, IL-1beta and IL-6). 3,4-dihydroxyphenylethanol 33-47 NADPH oxidase 1 Bos taurus 148-153 32756342-5 2020 RESULTS: Our results showed that hydroxytyrosol (10 and 25 muM) was able to prevent the oxidative stress induced by LPS (intracellular ROS, GSH and NOX-1) and the consequently inflammatory response (TNF-alpha, IL-1beta and IL-6). 3,4-dihydroxyphenylethanol 33-47 tumor necrosis factor Bos taurus 199-208 32756342-5 2020 RESULTS: Our results showed that hydroxytyrosol (10 and 25 muM) was able to prevent the oxidative stress induced by LPS (intracellular ROS, GSH and NOX-1) and the consequently inflammatory response (TNF-alpha, IL-1beta and IL-6). 3,4-dihydroxyphenylethanol 33-47 interleukin 1 alpha Bos taurus 210-218 32756342-5 2020 RESULTS: Our results showed that hydroxytyrosol (10 and 25 muM) was able to prevent the oxidative stress induced by LPS (intracellular ROS, GSH and NOX-1) and the consequently inflammatory response (TNF-alpha, IL-1beta and IL-6). 3,4-dihydroxyphenylethanol 33-47 interferon beta-2 Bos taurus 223-227 32756342-6 2020 The protective effect of hydroxytyrosol is also related to the enhancement of endogenous antioxidant systems (Nrf2, HO-1, NQO-1 and Txnrd1). 3,4-dihydroxyphenylethanol 25-39 NFE2 like bZIP transcription factor 2 Bos taurus 110-114 32756342-6 2020 The protective effect of hydroxytyrosol is also related to the enhancement of endogenous antioxidant systems (Nrf2, HO-1, NQO-1 and Txnrd1). 3,4-dihydroxyphenylethanol 25-39 heme oxygenase 1 Bos taurus 116-120 32756342-6 2020 The protective effect of hydroxytyrosol is also related to the enhancement of endogenous antioxidant systems (Nrf2, HO-1, NQO-1 and Txnrd1). 3,4-dihydroxyphenylethanol 25-39 NAD(P)H quinone dehydrogenase 1 Bos taurus 122-127 32756342-6 2020 The protective effect of hydroxytyrosol is also related to the enhancement of endogenous antioxidant systems (Nrf2, HO-1, NQO-1 and Txnrd1). 3,4-dihydroxyphenylethanol 25-39 thioredoxin reductase 1 Bos taurus 132-138 32629793-0 2020 Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin. 3,4-dihydroxyphenylethanol 0-14 insulin Homo sapiens 81-88 32572943-0 2020 Hydroxytyrosol suppresses LPS-induced intrahepatic inflammatory responses via inhibition of ERK signaling pathway activation in acute liver injury. 3,4-dihydroxyphenylethanol 0-14 mitogen-activated protein kinase 1 Mus musculus 92-95 32685494-0 2020 Hydroxytyrosol Plays Antiatherosclerotic Effects through Regulating Lipid Metabolism via Inhibiting the p38 Signal Pathway. 3,4-dihydroxyphenylethanol 0-14 mitogen-activated protein kinase 14 Mus musculus 104-107 32685494-6 2020 Results: HT administration significantly reduced the extent of atherosclerotic lesions in the aorta of apoE-/- mice. 3,4-dihydroxyphenylethanol 9-11 apolipoprotein E Mus musculus 103-107 32265301-8 2020 Pharmacological (hydroxytyrosol) and molecular (siRNA) interventions of ALOX12 in older NHFs suppressed their ability to stimulate proliferation of PDAC cells. 3,4-dihydroxyphenylethanol 17-31 arachidonate 12-lipoxygenase, 12S type Homo sapiens 72-78 31838605-8 2020 The HT-treated group also exhibited significantly higher Sertoli cell vimentin, myoid cell alpha-SMA and androgen receptor immune expression than the diabetic group. 3,4-dihydroxyphenylethanol 4-6 vimentin Rattus norvegicus 70-78 32247459-0 2020 Oleic acid and hydroxytyrosol present in olive oil promote ROS and inflammatory response in normal cultures of murine dermal fibroblasts through the NF-kappaB and NRF2 pathways. 3,4-dihydroxyphenylethanol 15-29 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 149-158 32247459-0 2020 Oleic acid and hydroxytyrosol present in olive oil promote ROS and inflammatory response in normal cultures of murine dermal fibroblasts through the NF-kappaB and NRF2 pathways. 3,4-dihydroxyphenylethanol 15-29 nuclear factor, erythroid derived 2, like 2 Mus musculus 163-167 31838605-10 2020 Significant upregulation of AMPK mRNA expression in the HT-treated group clarified the role of AMPK as an underlying molecular interface of the ameliorative effects of HT. 3,4-dihydroxyphenylethanol 56-58 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 28-32 31838605-10 2020 Significant upregulation of AMPK mRNA expression in the HT-treated group clarified the role of AMPK as an underlying molecular interface of the ameliorative effects of HT. 3,4-dihydroxyphenylethanol 56-58 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 95-99 31838605-10 2020 Significant upregulation of AMPK mRNA expression in the HT-treated group clarified the role of AMPK as an underlying molecular interface of the ameliorative effects of HT. 3,4-dihydroxyphenylethanol 168-170 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 28-32 31838605-10 2020 Significant upregulation of AMPK mRNA expression in the HT-treated group clarified the role of AMPK as an underlying molecular interface of the ameliorative effects of HT. 3,4-dihydroxyphenylethanol 168-170 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 95-99 31760852-6 2020 The PDGF-AB secretion and the soluble CD40 ligand (sCD40L) release by collagen were reduced by HT or OLE. 3,4-dihydroxyphenylethanol 95-97 CD40 molecule Homo sapiens 38-42 31756328-0 2020 Insight into the molecular mechanism underlying the inhibition of alpha-synuclein aggregation by hydroxytyrosol. 3,4-dihydroxyphenylethanol 97-111 synuclein alpha Homo sapiens 66-81 31756328-5 2020 This study is focused at describing the interaction between Syn and hydroxytyrosol (HT), the phenolic moiety and main metabolite of OleA, and the interferences with Syn aggregation by using biophysical and biological techniques. 3,4-dihydroxyphenylethanol 68-82 synemin Homo sapiens 60-63 31756328-5 2020 This study is focused at describing the interaction between Syn and hydroxytyrosol (HT), the phenolic moiety and main metabolite of OleA, and the interferences with Syn aggregation by using biophysical and biological techniques. 3,4-dihydroxyphenylethanol 84-86 synemin Homo sapiens 60-63 31756328-6 2020 Our results show that HT dose-dependently inhibits Syn aggregation and that covalent and non-covalent binding mediate HT-Syn interaction. 3,4-dihydroxyphenylethanol 22-24 synemin Homo sapiens 51-54 31760852-7 2020 HT and OLE significantly suppressed the phosphorylation of HSP27 and the release of phosphorylated-HSP27. 3,4-dihydroxyphenylethanol 0-2 heat shock protein family B (small) member 1 Homo sapiens 59-64 31760852-7 2020 HT and OLE significantly suppressed the phosphorylation of HSP27 and the release of phosphorylated-HSP27. 3,4-dihydroxyphenylethanol 0-2 heat shock protein family B (small) member 1 Homo sapiens 99-104 31585863-0 2020 Hydroxytyrosol inhibits MAO isoforms and prevents neurotoxicity inducible by MPP+ invivo. 3,4-dihydroxyphenylethanol 0-14 monoamine oxidase A Rattus norvegicus 24-27 32027412-5 2020 We found that treatment with HTyr activates neurogenesis in the dentate gyrus of adult, aged, and Btg1-null mice, by increasing survival of new neurons and decreasing apoptosis. 3,4-dihydroxyphenylethanol 29-33 BTG anti-proliferation factor 1 Mus musculus 98-102 32027412-6 2020 Notably, however, in the aged and Btg1-null dentate gyrus, HTyr treatment also stimulates the proliferation of stem and progenitor cells, whereas in the adult dentate gyrus HTyr lacks any proliferative effect. 3,4-dihydroxyphenylethanol 59-63 BTG anti-proliferation factor 1 Mus musculus 34-38 32027412-7 2020 Moreover, the new neurons generated in aged mice after HTyr treatment are recruited to existing circuits, as shown by the increase of BrdU+ /c-fos+ neurons. 3,4-dihydroxyphenylethanol 55-59 FBJ osteosarcoma oncogene Mus musculus 141-146 32027412-8 2020 Finally, HTyr treatment also reduces the markers of aging lipofuscin and Iba1. 3,4-dihydroxyphenylethanol 9-13 induction of brown adipocytes 1 Mus musculus 73-77 31866556-0 2020 Hydroxytyrosol Inhibits LPS-Induced Neuroinflammatory Responses via Suppression of TLR-4-Mediated NF-kappaB P65 Activation and ERK Signaling Pathway. 3,4-dihydroxyphenylethanol 0-14 toll-like receptor 4 Mus musculus 83-88 31866556-0 2020 Hydroxytyrosol Inhibits LPS-Induced Neuroinflammatory Responses via Suppression of TLR-4-Mediated NF-kappaB P65 Activation and ERK Signaling Pathway. 3,4-dihydroxyphenylethanol 0-14 mitogen-activated protein kinase 1 Mus musculus 127-130 31182175-13 2019 It was found that EGCG and HTyr elicited a reduction of the three inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and an increase of the anti-inflammatory cytokine IL-10. 3,4-dihydroxyphenylethanol 27-31 tumor necrosis factor Bos taurus 89-98 31182175-13 2019 It was found that EGCG and HTyr elicited a reduction of the three inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and an increase of the anti-inflammatory cytokine IL-10. 3,4-dihydroxyphenylethanol 27-31 interleukin 1 beta Bos taurus 100-108 31182175-13 2019 It was found that EGCG and HTyr elicited a reduction of the three inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and an increase of the anti-inflammatory cytokine IL-10. 3,4-dihydroxyphenylethanol 27-31 interferon beta-2 Bos taurus 110-114 31182175-13 2019 It was found that EGCG and HTyr elicited a reduction of the three inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and an increase of the anti-inflammatory cytokine IL-10. 3,4-dihydroxyphenylethanol 27-31 interleukin-10 Bos taurus 165-170 31503208-9 2019 However, on administering 10 mg/kg of DOPET, the neuronal function was rescued, antioxidants were restored back to the normal levels, LPO and MPO activities were reduced in conjunction with downregulated levels of proinflammatory cytokines and apoptotic markers in the SCI group. 3,4-dihydroxyphenylethanol 38-43 myeloperoxidase Rattus norvegicus 142-145 31521636-0 2019 Melatonin, protocatechuic acid and hydroxytyrosol effects on vitagenes system against alpha-synuclein toxicity. 3,4-dihydroxyphenylethanol 35-49 synuclein alpha Rattus norvegicus 86-101 31521636-2 2019 It has been reported that melatonin (MEL), protocatechuic acid (PCA) and hydroxytyrosol (HT) reduce alpha-Syn toxicity. 3,4-dihydroxyphenylethanol 73-87 synuclein alpha Rattus norvegicus 100-109 31521636-2 2019 It has been reported that melatonin (MEL), protocatechuic acid (PCA) and hydroxytyrosol (HT) reduce alpha-Syn toxicity. 3,4-dihydroxyphenylethanol 89-91 synuclein alpha Rattus norvegicus 100-109 30460610-0 2019 Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/beta-catenin and TGFbeta signaling pathways. 3,4-dihydroxyphenylethanol 0-14 Wnt family member 1 Homo sapiens 185-188 30460610-0 2019 Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/beta-catenin and TGFbeta signaling pathways. 3,4-dihydroxyphenylethanol 0-14 catenin beta 1 Homo sapiens 189-201 31545039-5 2019 Hydroxytyrosol, oleuropein, pinoresinol, squalene, and maslinic acid (0.1-10 muM) reverted DNA synthesis and Caco-2 cell growth induced by oleic acid. 3,4-dihydroxyphenylethanol 0-14 latexin Homo sapiens 77-80 31614459-0 2019 Anti-VEGF Signalling Mechanism in HUVECs by Melatonin, Serotonin, Hydroxytyrosol and Other Bioactive Compounds. 3,4-dihydroxyphenylethanol 66-80 vascular endothelial growth factor A Homo sapiens 5-9 31614459-3 2019 The aim was to provide insight into the anti-VEGF activity of bioactive compounds derived from aromatic amino acids (serotonin, melatonin, 3-indoleacetic acid, 5-hydroxytryptophol and hydroxytyrosol). 3,4-dihydroxyphenylethanol 184-198 vascular endothelial growth factor A Homo sapiens 45-49 30293230-10 2019 CONCLUSIONS: The combination of hydroxytyrosol, omega-3 fatty acids, and curcumin reduced inflammation as indicated by a reduction in CRP and reduced pain in patients with aromatase-induced musculoskeletal symptoms. 3,4-dihydroxyphenylethanol 32-46 C-reactive protein Homo sapiens 134-137 31540384-1 2019 Beer and wine contains the simple phenol tyrosol (TYR) which is endogenously converted into hydroxytyrosol (HT), one of the strongest dietary antioxidants, by CYP2A6 and CYP2D6 polymorphic enzymes. 3,4-dihydroxyphenylethanol 92-106 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 159-165 31540384-1 2019 Beer and wine contains the simple phenol tyrosol (TYR) which is endogenously converted into hydroxytyrosol (HT), one of the strongest dietary antioxidants, by CYP2A6 and CYP2D6 polymorphic enzymes. 3,4-dihydroxyphenylethanol 92-106 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 170-176 31540384-1 2019 Beer and wine contains the simple phenol tyrosol (TYR) which is endogenously converted into hydroxytyrosol (HT), one of the strongest dietary antioxidants, by CYP2A6 and CYP2D6 polymorphic enzymes. 3,4-dihydroxyphenylethanol 108-110 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 159-165 31540384-1 2019 Beer and wine contains the simple phenol tyrosol (TYR) which is endogenously converted into hydroxytyrosol (HT), one of the strongest dietary antioxidants, by CYP2A6 and CYP2D6 polymorphic enzymes. 3,4-dihydroxyphenylethanol 108-110 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 170-176 31279968-0 2019 Hydroxytyrosol prevents PM2.5-induced adiposity and insulin resistance by restraining oxidative stress related NF-kappaB pathway and modulation of gut microbiota in a murine model. 3,4-dihydroxyphenylethanol 0-14 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 111-120 31279968-13 2019 Further, with antioxidant NAC and NF-kappaB inhibitor PDTC, we confirmed that HT attenuated PM2.5-induced IR through restraining NF-kappaB activation evoked by oxidative stress. 3,4-dihydroxyphenylethanol 78-80 NLR family, pyrin domain containing 1A Mus musculus 26-29 31279968-13 2019 Further, with antioxidant NAC and NF-kappaB inhibitor PDTC, we confirmed that HT attenuated PM2.5-induced IR through restraining NF-kappaB activation evoked by oxidative stress. 3,4-dihydroxyphenylethanol 78-80 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 34-43 31279968-13 2019 Further, with antioxidant NAC and NF-kappaB inhibitor PDTC, we confirmed that HT attenuated PM2.5-induced IR through restraining NF-kappaB activation evoked by oxidative stress. 3,4-dihydroxyphenylethanol 78-80 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 129-138 30672618-2 2019 In vitro reactivity of hydrated CP species with Ole, and an Ole metabolite, hydroxytyrosol (HT), is of great interest as the preliminary step for gathering in vivo information on the possible physiological role of the Ole/HT-cis-diammineplatinum(II) (Ole/HT-cis-DAP) conjugate. 3,4-dihydroxyphenylethanol 76-90 death associated protein Homo sapiens 262-265 30672618-2 2019 In vitro reactivity of hydrated CP species with Ole, and an Ole metabolite, hydroxytyrosol (HT), is of great interest as the preliminary step for gathering in vivo information on the possible physiological role of the Ole/HT-cis-diammineplatinum(II) (Ole/HT-cis-DAP) conjugate. 3,4-dihydroxyphenylethanol 92-94 death associated protein Homo sapiens 262-265 31279968-0 2019 Hydroxytyrosol prevents PM2.5-induced adiposity and insulin resistance by restraining oxidative stress related NF-kappaB pathway and modulation of gut microbiota in a murine model. 3,4-dihydroxyphenylethanol 0-14 insulin Homo sapiens 52-59 29901389-0 2018 3,4-Dihydroxyphenylethanol Assuages Cognitive Impulsivity in Alzheimer"s Disease by Attuning HPA-Axis via Differential Crosstalk of alpha7 nAChR with MicroRNA-124 and HDAC6. 3,4-dihydroxyphenylethanol 0-26 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 132-144 30551508-0 2019 Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-gamma and NF-kappaB. 3,4-dihydroxyphenylethanol 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 166-170 30551508-0 2019 Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-gamma and NF-kappaB. 3,4-dihydroxyphenylethanol 0-14 sterol regulatory element binding transcription factor 1 Mus musculus 172-180 30551508-0 2019 Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-gamma and NF-kappaB. 3,4-dihydroxyphenylethanol 0-14 peroxisome proliferator activated receptor gamma Mus musculus 182-192 30551508-0 2019 Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-gamma and NF-kappaB. 3,4-dihydroxyphenylethanol 0-14 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 197-206 30599900-0 2019 Hydroxytyrosol NO regulates oxidative stress and NO production through SIRT1 in diabetic mice and vascular endothelial cells. 3,4-dihydroxyphenylethanol 0-14 sirtuin 1 Mus musculus 71-76 29901389-0 2018 3,4-Dihydroxyphenylethanol Assuages Cognitive Impulsivity in Alzheimer"s Disease by Attuning HPA-Axis via Differential Crosstalk of alpha7 nAChR with MicroRNA-124 and HDAC6. 3,4-dihydroxyphenylethanol 0-26 histone deacetylase 6 Mus musculus 167-172 29901389-8 2018 We opine that HPA-axis attunement by DOPET might be orchestrated through the alpha7 nAChR-mediated pathway. 3,4-dihydroxyphenylethanol 37-42 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 77-89 27914878-0 2017 Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death. 3,4-dihydroxyphenylethanol 0-14 sirtuin 1 Homo sapiens 65-74 30298817-3 2018 We previously reported that 12.5 microg/ml hydroxytyrosol (HT) suppressed gene expression of the inducible nitric oxide (NO) synthase (iNOS) isoform and NO production, in mouse peritoneal macrophages treated with lipopolysaccharide (LPS), where nuclear factor-kappaB (NF-kappaB) gene expression was not altered. 3,4-dihydroxyphenylethanol 43-57 nitric oxide synthase 2, inducible Mus musculus 135-139 30350961-0 2018 Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes. 3,4-dihydroxyphenylethanol 19-33 GLI family zinc finger 2 Homo sapiens 169-174 30350961-3 2018 The hydroxytyrosol-enriched olive vegetation waste also promoted autophagy and inhibited the inflammatory response in human THP-1 monocytes. 3,4-dihydroxyphenylethanol 4-18 GLI family zinc finger 2 Homo sapiens 124-129 30253891-0 2018 Corrigendum to "Protective effects of hydroxytyrosol against alpha-synuclein toxicity on PC12 cells and fibril formation" [Food Chem. 3,4-dihydroxyphenylethanol 38-52 synuclein alpha Rattus norvegicus 61-76 29964084-0 2018 Protective effects of hydroxytyrosol against alpha-synuclein toxicity on PC12 cells and fibril formation. 3,4-dihydroxyphenylethanol 22-36 synuclein alpha Rattus norvegicus 45-60 30004416-8 2018 Oleuropein displayed selective toxicity towards MIA PaCa-2 cells and hydroxytyrosol towards MIA PaCa-2 and HPDE cells. 3,4-dihydroxyphenylethanol 69-83 MIA SH3 domain containing Homo sapiens 92-95 30004416-9 2018 Subsequent analysis of Bcl-2 family proteins and caspase 3/7 activation determined that oleuropein and hydroxytyrosol induced apoptosis in MIA PaCa-2 cells, while oleuropein displayed a protective effect on HPDE cells. 3,4-dihydroxyphenylethanol 103-117 MIA SH3 domain containing Homo sapiens 139-142 30004416-10 2018 Gene expression analysis revealed putative mechanisms of action, which suggested that c-Jun and c-Fos are involved in oleuropein and hydroxytyrosol induced apoptosis of MIA PaCa-2 cells. 3,4-dihydroxyphenylethanol 133-147 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 86-91 30004416-10 2018 Gene expression analysis revealed putative mechanisms of action, which suggested that c-Jun and c-Fos are involved in oleuropein and hydroxytyrosol induced apoptosis of MIA PaCa-2 cells. 3,4-dihydroxyphenylethanol 133-147 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 96-101 30004416-10 2018 Gene expression analysis revealed putative mechanisms of action, which suggested that c-Jun and c-Fos are involved in oleuropein and hydroxytyrosol induced apoptosis of MIA PaCa-2 cells. 3,4-dihydroxyphenylethanol 133-147 MIA SH3 domain containing Homo sapiens 169-172 29694939-0 2018 Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2/HO1 and JAK/STAT signaling pathways. 3,4-dihydroxyphenylethanol 14-28 nuclear factor, erythroid derived 2, like 2 Mus musculus 185-189 29694939-0 2018 Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2/HO1 and JAK/STAT signaling pathways. 3,4-dihydroxyphenylethanol 14-28 signal transducer and activator of transcription 3 Mus musculus 202-206 29286133-0 2018 Hydroxytyrosol inhibits the inflammatory response of osteoarthritis chondrocytes via SIRT6-mediated autophagy. 3,4-dihydroxyphenylethanol 0-14 sirtuin 6 Homo sapiens 85-90 29373553-6 2018 We found that oleuropein increased all the activities analyzed and promoted a pro-inflammatory status, whereas hydroxytyrosol only modified ASAP and IRAP activities and promotes an anti-inflammatory status. 3,4-dihydroxyphenylethanol 111-125 leucyl and cystinyl aminopeptidase Homo sapiens 149-153 29078076-0 2018 Involvement of bilitranslocase and beta-glucuronidase in the vascular protection by hydroxytyrosol and its glucuronide metabolites in oxidative stress conditions. 3,4-dihydroxyphenylethanol 84-98 ceruloplasmin Rattus norvegicus 15-30 29078076-0 2018 Involvement of bilitranslocase and beta-glucuronidase in the vascular protection by hydroxytyrosol and its glucuronide metabolites in oxidative stress conditions. 3,4-dihydroxyphenylethanol 84-98 glucuronidase, beta Rattus norvegicus 35-53 29137335-1 2017 Hydroxytyrosol (HT), a polyphenol of olive oil, downregulates epidermal growth factor (EGFR) expression and inhibits cell proliferation in colon cancer (CC) cells, with mechanisms similar to that activated by the EGFR inhibitor, cetuximab. 3,4-dihydroxyphenylethanol 0-14 epidermal growth factor receptor Homo sapiens 87-91 29137335-1 2017 Hydroxytyrosol (HT), a polyphenol of olive oil, downregulates epidermal growth factor (EGFR) expression and inhibits cell proliferation in colon cancer (CC) cells, with mechanisms similar to that activated by the EGFR inhibitor, cetuximab. 3,4-dihydroxyphenylethanol 0-14 epidermal growth factor receptor Homo sapiens 213-217 28386616-0 2017 Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-alpha and Nrf2 activation, and NF-kappaB down-regulation. 3,4-dihydroxyphenylethanol 59-73 peroxisome proliferator activated receptor alpha Mus musculus 147-157 28386616-0 2017 Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-alpha and Nrf2 activation, and NF-kappaB down-regulation. 3,4-dihydroxyphenylethanol 59-73 nuclear factor, erythroid derived 2, like 2 Mus musculus 162-166 28386616-0 2017 Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-alpha and Nrf2 activation, and NF-kappaB down-regulation. 3,4-dihydroxyphenylethanol 59-73 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 183-192 28386616-2 2017 Hydroxytyrosol (HT), a polyphenol with cytoprotective effects present in extra virgin olive oil, improves the cellular antioxidant capacity for activation of transcription factor Nrf2. 3,4-dihydroxyphenylethanol 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 179-183 29760296-0 2018 Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression. 3,4-dihydroxyphenylethanol 0-14 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 83-88 29760296-0 2018 Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression. 3,4-dihydroxyphenylethanol 0-14 DNA-damage inducible transcript 3 Rattus norvegicus 93-97 29760296-7 2018 Hydroxytyrosol could reduce the mRNA and protein expression of GRP78 and CHOP induced by CoCl2 in vitro. 3,4-dihydroxyphenylethanol 0-14 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 63-68 29760296-7 2018 Hydroxytyrosol could reduce the mRNA and protein expression of GRP78 and CHOP induced by CoCl2 in vitro. 3,4-dihydroxyphenylethanol 0-14 DNA-damage inducible transcript 3 Rattus norvegicus 73-77 29373553-5 2018 Using this glioma model, here we analyze the effects of the phenolic compounds oleuropein and hydroxytyrosol in circulating RAS-regulating ASAP, APA, APN, APB and IRAP specific activities and the pro-inflammatory cytokines IL-6 and TNFalpha to understand the relationship between the antitumor and anti-inflammatory effects of hydroxytyrosol, but not oleuropein, and the components of the RAS. 3,4-dihydroxyphenylethanol 94-108 aspartyl aminopeptidase Homo sapiens 139-143 29373553-5 2018 Using this glioma model, here we analyze the effects of the phenolic compounds oleuropein and hydroxytyrosol in circulating RAS-regulating ASAP, APA, APN, APB and IRAP specific activities and the pro-inflammatory cytokines IL-6 and TNFalpha to understand the relationship between the antitumor and anti-inflammatory effects of hydroxytyrosol, but not oleuropein, and the components of the RAS. 3,4-dihydroxyphenylethanol 94-108 glutamyl aminopeptidase Homo sapiens 145-148 29373553-5 2018 Using this glioma model, here we analyze the effects of the phenolic compounds oleuropein and hydroxytyrosol in circulating RAS-regulating ASAP, APA, APN, APB and IRAP specific activities and the pro-inflammatory cytokines IL-6 and TNFalpha to understand the relationship between the antitumor and anti-inflammatory effects of hydroxytyrosol, but not oleuropein, and the components of the RAS. 3,4-dihydroxyphenylethanol 94-108 alanyl aminopeptidase, membrane Homo sapiens 150-153 29373553-5 2018 Using this glioma model, here we analyze the effects of the phenolic compounds oleuropein and hydroxytyrosol in circulating RAS-regulating ASAP, APA, APN, APB and IRAP specific activities and the pro-inflammatory cytokines IL-6 and TNFalpha to understand the relationship between the antitumor and anti-inflammatory effects of hydroxytyrosol, but not oleuropein, and the components of the RAS. 3,4-dihydroxyphenylethanol 94-108 arginyl aminopeptidase Homo sapiens 155-158 29373553-5 2018 Using this glioma model, here we analyze the effects of the phenolic compounds oleuropein and hydroxytyrosol in circulating RAS-regulating ASAP, APA, APN, APB and IRAP specific activities and the pro-inflammatory cytokines IL-6 and TNFalpha to understand the relationship between the antitumor and anti-inflammatory effects of hydroxytyrosol, but not oleuropein, and the components of the RAS. 3,4-dihydroxyphenylethanol 94-108 leucyl and cystinyl aminopeptidase Homo sapiens 163-167 29373553-5 2018 Using this glioma model, here we analyze the effects of the phenolic compounds oleuropein and hydroxytyrosol in circulating RAS-regulating ASAP, APA, APN, APB and IRAP specific activities and the pro-inflammatory cytokines IL-6 and TNFalpha to understand the relationship between the antitumor and anti-inflammatory effects of hydroxytyrosol, but not oleuropein, and the components of the RAS. 3,4-dihydroxyphenylethanol 94-108 interleukin 6 Homo sapiens 223-227 29373553-5 2018 Using this glioma model, here we analyze the effects of the phenolic compounds oleuropein and hydroxytyrosol in circulating RAS-regulating ASAP, APA, APN, APB and IRAP specific activities and the pro-inflammatory cytokines IL-6 and TNFalpha to understand the relationship between the antitumor and anti-inflammatory effects of hydroxytyrosol, but not oleuropein, and the components of the RAS. 3,4-dihydroxyphenylethanol 94-108 tumor necrosis factor Homo sapiens 232-240 29373553-6 2018 We found that oleuropein increased all the activities analyzed and promoted a pro-inflammatory status, whereas hydroxytyrosol only modified ASAP and IRAP activities and promotes an anti-inflammatory status. 3,4-dihydroxyphenylethanol 111-125 aspartyl aminopeptidase Homo sapiens 140-144 29953618-10 2018 Hydroxytyrosol (HT) was observed to reduce lipid accumulation, FMO3 expression as well as inflammatory response. 3,4-dihydroxyphenylethanol 0-14 flavin containing monooxygenase 3 Mus musculus 63-67 28802898-6 2017 CART (55-102) peptide, 0.1muM, added alone, exerted: (i) a significant decrease in the basal and EFS-evoked levels of extracellular dopamine (ii) a significant increase in the EFS-evoked and returning basal levels of the dopamine metabolites DOPAC and HVA, major products of dopamine degradation and (iii) a significant decrease in the returning basal levels of DOPET. 3,4-dihydroxyphenylethanol 362-367 CART prepropeptide Mus musculus 0-4 27998828-3 2017 Human granulocytes and monocytes were stimulated with phorbol myristate acetate (PMA) and the ability of resveratrol, hydroxytyrosol and oleuropein to inhibit the oxidative burst and CD11b expression was measured. 3,4-dihydroxyphenylethanol 118-132 integrin subunit alpha M Homo sapiens 183-188 27664690-0 2017 CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol. 3,4-dihydroxyphenylethanol 52-66 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 0-6 27664690-0 2017 CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol. 3,4-dihydroxyphenylethanol 52-66 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 11-17 27664690-7 2017 Studies with baculosomes further demonstrated that CYP2D6 and CYP3A4 could transform tyrosol into hydroxytyrosol. 3,4-dihydroxyphenylethanol 98-112 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 51-57 27664690-7 2017 Studies with baculosomes further demonstrated that CYP2D6 and CYP3A4 could transform tyrosol into hydroxytyrosol. 3,4-dihydroxyphenylethanol 98-112 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 62-68 27664690-8 2017 Experiments using human genotyped livers showed an interindividual variability in hydroxytyrosol formation and supported findings that CYP2D6 and CYP2A6 mediated this reaction. 3,4-dihydroxyphenylethanol 82-96 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 135-141 27664690-8 2017 Experiments using human genotyped livers showed an interindividual variability in hydroxytyrosol formation and supported findings that CYP2D6 and CYP2A6 mediated this reaction. 3,4-dihydroxyphenylethanol 82-96 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 146-152 27998828-11 2017 Resveratrol and hydroxytyrosol 10muM induced NRf2 nuclear translocation and reduced miR-146a expression in LPS treated RAW 264.7. 3,4-dihydroxyphenylethanol 16-30 latexin Homo sapiens 33-36 27998828-11 2017 Resveratrol and hydroxytyrosol 10muM induced NRf2 nuclear translocation and reduced miR-146a expression in LPS treated RAW 264.7. 3,4-dihydroxyphenylethanol 16-30 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 27998828-11 2017 Resveratrol and hydroxytyrosol 10muM induced NRf2 nuclear translocation and reduced miR-146a expression in LPS treated RAW 264.7. 3,4-dihydroxyphenylethanol 16-30 microRNA 146a Homo sapiens 84-92 27998828-7 2017 All the tested compounds inhibited granulocytes oxidative burst in a concentration dependent manner and CD11b expression was also significantly counteracted by resveratrol and hydroxytyrosol. 3,4-dihydroxyphenylethanol 176-190 integrin subunit alpha M Homo sapiens 104-109 27998828-12 2017 Overall, we reported an anti-inflammatory effect of resveratrol and hydroxytyrosol at low, nutritionally relevant concentrations, involving the inhibition of granulocytes and monocytes activation, the modulation of miR-146a expression and the activation of Nrf2. 3,4-dihydroxyphenylethanol 68-82 microRNA 146a Homo sapiens 215-223 27998828-12 2017 Overall, we reported an anti-inflammatory effect of resveratrol and hydroxytyrosol at low, nutritionally relevant concentrations, involving the inhibition of granulocytes and monocytes activation, the modulation of miR-146a expression and the activation of Nrf2. 3,4-dihydroxyphenylethanol 68-82 NFE2 like bZIP transcription factor 2 Homo sapiens 257-261 27592355-2 2017 METHODS: In this study, we evaluated the activities of hydroxytyrosol against papillary (TPC-1, FB-2) and follicular (WRO) thyroid cancer cell lines. 3,4-dihydroxyphenylethanol 55-69 two pore segment channel 1 Homo sapiens 89-94 27592355-3 2017 RESULTS: Cellular viability revealed that high doses of hydroxytyrosol reduced cancer cells viability concomitantly with a reduction of cyclin D1 expression and an up-regulation of cell cycle key modulator p21 levels. 3,4-dihydroxyphenylethanol 56-70 cyclin D1 Homo sapiens 136-145 27592355-3 2017 RESULTS: Cellular viability revealed that high doses of hydroxytyrosol reduced cancer cells viability concomitantly with a reduction of cyclin D1 expression and an up-regulation of cell cycle key modulator p21 levels. 3,4-dihydroxyphenylethanol 56-70 H3 histone pseudogene 16 Homo sapiens 206-209 27592355-4 2017 In the same experimental conditions, Annexin V-PI staining and DNA laddering revealed that hydroxytyrosol exerts proapoptotic effects on papillary and follicular cancer cells. 3,4-dihydroxyphenylethanol 91-105 annexin A5 Homo sapiens 37-46 27810738-6 2016 Moreover, hydroxytyrosol (but not tyrosol), was able to diminish the late sustained phase of H2O2-induced JNK and p38 phosphorylation. 3,4-dihydroxyphenylethanol 10-24 mitogen-activated protein kinase 14 Homo sapiens 114-117 27475990-0 2016 Hydroxytyrosol modulates Par j 1-induced IL-10 production by PBMCs in healthy subjects. 3,4-dihydroxyphenylethanol 0-14 interleukin 10 Homo sapiens 41-46 27475990-3 2016 In this report, we demonstrate that the co-stimulation of human PBMCs from healthy subjects with the Par j 1 allergen and hydroxytyrosol induced a statistically significant increase in the amount of Par j 1-induced IL-10, demonstrating that hydroxytyrosol can modulate an allergen-specific immune response potentiating a suppressive immune response towards an allergen. 3,4-dihydroxyphenylethanol 122-136 interleukin 10 Homo sapiens 215-220 27475990-3 2016 In this report, we demonstrate that the co-stimulation of human PBMCs from healthy subjects with the Par j 1 allergen and hydroxytyrosol induced a statistically significant increase in the amount of Par j 1-induced IL-10, demonstrating that hydroxytyrosol can modulate an allergen-specific immune response potentiating a suppressive immune response towards an allergen. 3,4-dihydroxyphenylethanol 241-255 interleukin 10 Homo sapiens 215-220 26966340-0 2016 Hydroxytyrosol Protects against Myocardial Ischemia/Reperfusion Injury through a PI3K/Akt-Dependent Mechanism. 3,4-dihydroxyphenylethanol 0-14 AKT serine/threonine kinase 1 Rattus norvegicus 86-89 27287957-0 2016 Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice. 3,4-dihydroxyphenylethanol 0-14 presenilin 1 Mus musculus 86-89 27287957-6 2016 In addition, HT treatment ameliorated mitochondrial dysfunction, reduced mitochondrial carbonyl protein, enhanced superoxide dismutase 2 expression, reversed the phase 2 enzyme system and reduced the levels of brain inflammatory markers, but had no effect on brain beta-amyloid (Abeta) accumulation in APP/PS1 mice. 3,4-dihydroxyphenylethanol 13-15 amyloid beta (A4) precursor protein Mus musculus 279-284 27287957-6 2016 In addition, HT treatment ameliorated mitochondrial dysfunction, reduced mitochondrial carbonyl protein, enhanced superoxide dismutase 2 expression, reversed the phase 2 enzyme system and reduced the levels of brain inflammatory markers, but had no effect on brain beta-amyloid (Abeta) accumulation in APP/PS1 mice. 3,4-dihydroxyphenylethanol 13-15 presenilin 1 Mus musculus 306-309 27287014-5 2016 Hydroxytyrosol-treated P20 cells significantly (P < 0.05) increased expression of genes involved in inhibition of adipogenesis, such as GATA2, GATA3, WNT3A, SFRP5, HES1, and SIRT1. 3,4-dihydroxyphenylethanol 0-14 tubulin polymerization promoting protein family member 3 Homo sapiens 23-26 27287014-5 2016 Hydroxytyrosol-treated P20 cells significantly (P < 0.05) increased expression of genes involved in inhibition of adipogenesis, such as GATA2, GATA3, WNT3A, SFRP5, HES1, and SIRT1. 3,4-dihydroxyphenylethanol 0-14 GATA binding protein 2 Homo sapiens 139-144 27287014-5 2016 Hydroxytyrosol-treated P20 cells significantly (P < 0.05) increased expression of genes involved in inhibition of adipogenesis, such as GATA2, GATA3, WNT3A, SFRP5, HES1, and SIRT1. 3,4-dihydroxyphenylethanol 0-14 GATA binding protein 3 Homo sapiens 146-151 27287014-5 2016 Hydroxytyrosol-treated P20 cells significantly (P < 0.05) increased expression of genes involved in inhibition of adipogenesis, such as GATA2, GATA3, WNT3A, SFRP5, HES1, and SIRT1. 3,4-dihydroxyphenylethanol 0-14 Wnt family member 3A Homo sapiens 153-158 27287014-5 2016 Hydroxytyrosol-treated P20 cells significantly (P < 0.05) increased expression of genes involved in inhibition of adipogenesis, such as GATA2, GATA3, WNT3A, SFRP5, HES1, and SIRT1. 3,4-dihydroxyphenylethanol 0-14 secreted frizzled related protein 5 Homo sapiens 160-165 27287014-5 2016 Hydroxytyrosol-treated P20 cells significantly (P < 0.05) increased expression of genes involved in inhibition of adipogenesis, such as GATA2, GATA3, WNT3A, SFRP5, HES1, and SIRT1. 3,4-dihydroxyphenylethanol 0-14 hes family bHLH transcription factor 1 Homo sapiens 167-171 27287014-5 2016 Hydroxytyrosol-treated P20 cells significantly (P < 0.05) increased expression of genes involved in inhibition of adipogenesis, such as GATA2, GATA3, WNT3A, SFRP5, HES1, and SIRT1. 3,4-dihydroxyphenylethanol 0-14 sirtuin 1 Homo sapiens 177-182 27287014-6 2016 In contrast, genes involved in promoting adipogenesis such as LEP, FGF1, CCND1, and SREBF1 were significantly down-regulated by hydroxytyrosol treatment. 3,4-dihydroxyphenylethanol 128-142 leptin Homo sapiens 62-65 27287014-6 2016 In contrast, genes involved in promoting adipogenesis such as LEP, FGF1, CCND1, and SREBF1 were significantly down-regulated by hydroxytyrosol treatment. 3,4-dihydroxyphenylethanol 128-142 fibroblast growth factor 1 Homo sapiens 67-71 27287014-6 2016 In contrast, genes involved in promoting adipogenesis such as LEP, FGF1, CCND1, and SREBF1 were significantly down-regulated by hydroxytyrosol treatment. 3,4-dihydroxyphenylethanol 128-142 cyclin D1 Homo sapiens 73-78 27287014-6 2016 In contrast, genes involved in promoting adipogenesis such as LEP, FGF1, CCND1, and SREBF1 were significantly down-regulated by hydroxytyrosol treatment. 3,4-dihydroxyphenylethanol 128-142 sterol regulatory element binding transcription factor 1 Homo sapiens 84-90 27220335-7 2016 Co-incubation with hydroxytyrosol prevented the increases in Cys-DA seen with all 3 MAO inhibitors. 3,4-dihydroxyphenylethanol 19-33 monoamine oxidase A Rattus norvegicus 84-87 27220335-8 2016 Hydroxytyrosol therefore inhibits both enzymatic and spontaneous oxidation of endogenous dopamine and mitigates the increase in spontaneous oxidation during MAO inhibition. 3,4-dihydroxyphenylethanol 0-14 monoamine oxidase A Rattus norvegicus 157-160 27016717-0 2016 Oleic acid, hydroxytyrosol and n-3 fatty acids collectively modulate colitis through reduction of oxidative stress and IL-8 synthesis; in vitro and in vivo studies. 3,4-dihydroxyphenylethanol 12-26 C-X-C motif chemokine ligand 8 Homo sapiens 119-123 27168841-0 2016 3,4-Dihydroxyphenylethanol alleviates early brain injury by modulating oxidative stress and Akt and nuclear factor-kappaB pathways in a rat model of subarachnoid hemorrhage. 3,4-dihydroxyphenylethanol 0-26 AKT serine/threonine kinase 1 Rattus norvegicus 92-95 26189725-0 2016 Hydroxytyrosol Inhibits Cannabinoid CB1 Receptor Gene Expression in 3T3-L1 Preadipocyte Cell Line. 3,4-dihydroxyphenylethanol 0-14 cannabinoid receptor 1 (brain) Mus musculus 36-39 26469183-4 2016 Furthermore we extensively analysed, by the MTT assay, the anti-proliferative activities of 3,4-DHPEA on breast (MDA and MCF-7), prostate (LNCap and PC3) and colon (SW480 and HCT116) cancer cell lines and correlated these effects with the H2O2 accumulation. 3,4-dihydroxyphenylethanol 92-101 chromobox 8 Homo sapiens 149-152 27287014-1 2016 Hydroxytyrosol has various pharmacological properties, including anti-oxidative stress and anti-inflammatory activities, preventing hyperglycemia, insulin resistance, and the metabolic syndrome. 3,4-dihydroxyphenylethanol 0-14 insulin Homo sapiens 147-154 27287014-4 2016 The treatment with hydroxytyrosol extract significantly (P < 0.001) increased apoptosis in P10 and P20 cells in comparison to control and A7 cells; significantly (P < 0.001) reduced triglyceride accumulation in P20 cells compared to P10 and control cells; and significantly (P < 0.001) increased lipolysis in P20 cells in comparison to control cells and A7 mature adipocytes. 3,4-dihydroxyphenylethanol 19-33 S100 calcium binding protein A10 Homo sapiens 94-97 27287014-4 2016 The treatment with hydroxytyrosol extract significantly (P < 0.001) increased apoptosis in P10 and P20 cells in comparison to control and A7 cells; significantly (P < 0.001) reduced triglyceride accumulation in P20 cells compared to P10 and control cells; and significantly (P < 0.001) increased lipolysis in P20 cells in comparison to control cells and A7 mature adipocytes. 3,4-dihydroxyphenylethanol 19-33 tubulin polymerization promoting protein family member 3 Homo sapiens 102-105 27287014-4 2016 The treatment with hydroxytyrosol extract significantly (P < 0.001) increased apoptosis in P10 and P20 cells in comparison to control and A7 cells; significantly (P < 0.001) reduced triglyceride accumulation in P20 cells compared to P10 and control cells; and significantly (P < 0.001) increased lipolysis in P20 cells in comparison to control cells and A7 mature adipocytes. 3,4-dihydroxyphenylethanol 19-33 tubulin polymerization promoting protein family member 3 Homo sapiens 217-220 27287014-4 2016 The treatment with hydroxytyrosol extract significantly (P < 0.001) increased apoptosis in P10 and P20 cells in comparison to control and A7 cells; significantly (P < 0.001) reduced triglyceride accumulation in P20 cells compared to P10 and control cells; and significantly (P < 0.001) increased lipolysis in P20 cells in comparison to control cells and A7 mature adipocytes. 3,4-dihydroxyphenylethanol 19-33 S100 calcium binding protein A10 Homo sapiens 239-242 27287014-4 2016 The treatment with hydroxytyrosol extract significantly (P < 0.001) increased apoptosis in P10 and P20 cells in comparison to control and A7 cells; significantly (P < 0.001) reduced triglyceride accumulation in P20 cells compared to P10 and control cells; and significantly (P < 0.001) increased lipolysis in P20 cells in comparison to control cells and A7 mature adipocytes. 3,4-dihydroxyphenylethanol 19-33 tubulin polymerization promoting protein family member 3 Homo sapiens 217-220 27220335-0 2016 3,4-Dihydroxyphenylethanol (Hydroxytyrosol) Mitigates the Increase in Spontaneous Oxidation of Dopamine During Monoamine Oxidase Inhibition in PC12 Cells. 3,4-dihydroxyphenylethanol 0-26 monoamine oxidase A Rattus norvegicus 111-128 27220335-0 2016 3,4-Dihydroxyphenylethanol (Hydroxytyrosol) Mitigates the Increase in Spontaneous Oxidation of Dopamine During Monoamine Oxidase Inhibition in PC12 Cells. 3,4-dihydroxyphenylethanol 28-42 monoamine oxidase A Rattus norvegicus 111-128 27476321-0 2016 Investigations on the Reaction of C3 and C6 alpha-Dicarbonyl Compounds with Hydroxytyrosol and Related Compounds under Competitive Conditions. 3,4-dihydroxyphenylethanol 76-90 complement C3 Homo sapiens 34-49 26947008-0 2016 Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms. 3,4-dihydroxyphenylethanol 0-14 sirtuin 1 Homo sapiens 95-104 26608793-0 2016 Hydroxytyrosol decreases the oxidative and nitrosative stress levels and promotes angiogenesis through HIF-1 independent mechanisms in renal hypoxic cells. 3,4-dihydroxyphenylethanol 0-14 hypoxia inducible factor 1 subunit alpha Homo sapiens 103-108 26904279-0 2016 Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea). 3,4-dihydroxyphenylethanol 63-72 ectodysplasin-A Rattus norvegicus 73-76 26904279-1 2016 Absorption, metabolism, and excretion of 3,4-DHPEA-EDA, oleuropein, and hydroxytyrosol isolated from olive fruits were newly evaluated after oral and intravenous administration in freely moving rats cannulated in the portal vein, jugular vein, and bile duct. 3,4-dihydroxyphenylethanol 41-50 ectodysplasin-A Rattus norvegicus 51-54 26904279-2 2016 Orally administered 3,4-DHPEA-EDA, an important bioactive compound in olive pomace, was readily absorbed and metabolized to hydroxytyrosol, homovanillic acid, and homovanillyl alcohol, as shown by dose-normalized 4 h area under the curve (AUC0 4 h/Dose) values of 27.7, 4.5, and 4.2 muM min kg/mumol, respectively, in portal plasma after oral administration. 3,4-dihydroxyphenylethanol 124-138 ectodysplasin-A Rattus norvegicus 30-33 26904279-3 2016 The parent compound 3,4-DHPEA-EDA was not observed in the portal plasma, urine, and bile after oral and intravenous administration. 3,4-dihydroxyphenylethanol 20-29 ectodysplasin-A Rattus norvegicus 30-33 26904279-8 2016 Because the amount of 3,4-DHPEA-EDA in olive fruits is about 2-3 times greater than that of hydroxytyrosol, the metabolites of 3,4-DHPEA-EDA will influence biological activities. 3,4-dihydroxyphenylethanol 22-31 ectodysplasin-A Rattus norvegicus 32-35 26904279-8 2016 Because the amount of 3,4-DHPEA-EDA in olive fruits is about 2-3 times greater than that of hydroxytyrosol, the metabolites of 3,4-DHPEA-EDA will influence biological activities. 3,4-dihydroxyphenylethanol 22-31 ectodysplasin-A Rattus norvegicus 137-140 26904279-8 2016 Because the amount of 3,4-DHPEA-EDA in olive fruits is about 2-3 times greater than that of hydroxytyrosol, the metabolites of 3,4-DHPEA-EDA will influence biological activities. 3,4-dihydroxyphenylethanol 92-106 ectodysplasin-A Rattus norvegicus 137-140 26374991-5 2015 Pretreatment with quercetin or hydroxytyrosol attenuated the phosphorylation of MAPKAPK-2 and cleaved caspase-3 in X/XO-exposed cells (p < 0.01, vs. X/XO). 3,4-dihydroxyphenylethanol 31-45 MAPK activated protein kinase 2 Homo sapiens 80-89 26655408-1 2015 BACKGROUND: Oleacein (dialdehydic form of decarboxymethyl elenolic acid linked to hydroxytyrosol; 3,4-DHPEA-EDA) have been proven to possess antioxidant and anti-inflammatory activity. 3,4-dihydroxyphenylethanol 82-96 ectodysplasin A Homo sapiens 108-111 26434999-7 2015 The alginate bilayer films containing Hidrox( ), HB2, showed controlled release of hydroxytyrosol at a flux of 0.094+-0.009 mg/cm(2)/h. 3,4-dihydroxyphenylethanol 83-97 keratin 82 Homo sapiens 49-52 26374991-6 2015 Hydroxytyrosol enhanced the reduction of phosphorylation of a transcriptional target c-Jun and led to overphosphorylation in protective proteins, p44/42-MAPK and Hsp27 in X/XO-exposed cells (p < 0.01, vs. X/XO). 3,4-dihydroxyphenylethanol 0-14 heat shock protein family B (small) member 1 Homo sapiens 162-167 26374991-5 2015 Pretreatment with quercetin or hydroxytyrosol attenuated the phosphorylation of MAPKAPK-2 and cleaved caspase-3 in X/XO-exposed cells (p < 0.01, vs. X/XO). 3,4-dihydroxyphenylethanol 31-45 caspase 3 Homo sapiens 102-111 26374991-6 2015 Hydroxytyrosol enhanced the reduction of phosphorylation of a transcriptional target c-Jun and led to overphosphorylation in protective proteins, p44/42-MAPK and Hsp27 in X/XO-exposed cells (p < 0.01, vs. X/XO). 3,4-dihydroxyphenylethanol 0-14 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 85-90 26374991-6 2015 Hydroxytyrosol enhanced the reduction of phosphorylation of a transcriptional target c-Jun and led to overphosphorylation in protective proteins, p44/42-MAPK and Hsp27 in X/XO-exposed cells (p < 0.01, vs. X/XO). 3,4-dihydroxyphenylethanol 0-14 interferon induced protein 44 Homo sapiens 146-149 26235001-0 2015 The alpha-Glucosidase and alpha-Amylase Enzyme Inhibitory of Hydroxytyrosol and Oleuropein. 3,4-dihydroxyphenylethanol 61-75 sucrase-isomaltase Homo sapiens 4-21 26260341-0 2015 Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses. 3,4-dihydroxyphenylethanol 69-83 tyrosinase Homo sapiens 27-37 26260341-1 2015 Hydroxytyrosol and dihydrocaffeoyl catechols with lipophilic properties have been synthesized in high yield using tyrosinase immobilized on multi-walled carbon nanotubes by the Layer-by-Layer technique. 3,4-dihydroxyphenylethanol 0-14 tyrosinase Homo sapiens 114-124 26783228-3 2015 administration of a blend of olive (Olea europaea L.) polyphenols (10 mg/kg) containing mostly hydroxytyrosol could have an effect on cytokines playing important roles in inflammatory processes as TNF-alpha and IL-10. 3,4-dihydroxyphenylethanol 95-109 tumor necrosis factor Mus musculus 197-206 26783228-3 2015 administration of a blend of olive (Olea europaea L.) polyphenols (10 mg/kg) containing mostly hydroxytyrosol could have an effect on cytokines playing important roles in inflammatory processes as TNF-alpha and IL-10. 3,4-dihydroxyphenylethanol 95-109 interleukin 10 Mus musculus 211-216 26143179-9 2015 While Leptin mRNA could not be detected in mouse whole blood, there was an induction of Mest mRNA by HFD which was suppressed by hydroxytyrosol. 3,4-dihydroxyphenylethanol 129-143 mesoderm specific transcript Mus musculus 88-92 25866079-0 2015 The hydroxytyrosol-dependent increase of TNF-alpha in LPS-activated human monocytes is mediated by PGE2 and adenylate cyclase activation. 3,4-dihydroxyphenylethanol 4-18 tumor necrosis factor Homo sapiens 41-50 25866079-2 2015 We have recently reported that in LPS-activated human monocytes hydroxytyrosol, the main phenol present in extra virgin olive oil reduced both the COX-2 gene expression and PGE2 secretion while it increased the TNF-alpha accumulation in the culture medium. 3,4-dihydroxyphenylethanol 64-78 tumor necrosis factor Homo sapiens 211-220 25866079-4 2015 We found that hydroxytyrosol (100 muM) increased the TNF-alpha mRNA level in LPS-activated human monocytes as evaluated by both RT-PCR and real time PCR (qPCR). 3,4-dihydroxyphenylethanol 14-28 tumor necrosis factor Homo sapiens 53-62 26030149-0 2015 Additive regulation of adiponectin expression by the mediterranean diet olive oil components oleic Acid and hydroxytyrosol in human adipocytes. 3,4-dihydroxyphenylethanol 108-122 adiponectin, C1Q and collagen domain containing Homo sapiens 23-34 26235001-2 2015 The objective of this research was to evaluate the inhibitory effect of the hydroxytyrosol and the oleuropein against alpha-amylase and alpha-glucosidase. 3,4-dihydroxyphenylethanol 76-90 sucrase-isomaltase Homo sapiens 136-153 26235001-4 2015 The result shows that the hydroxytyrosol had the strongest alpha-glucosidase inhibitory effect with IC50 values of 150 muM with mild inhibition against alpha-amylase. 3,4-dihydroxyphenylethanol 26-40 sucrase-isomaltase Homo sapiens 59-76 26235001-4 2015 The result shows that the hydroxytyrosol had the strongest alpha-glucosidase inhibitory effect with IC50 values of 150 muM with mild inhibition against alpha-amylase. 3,4-dihydroxyphenylethanol 26-40 latexin Homo sapiens 119-122 26235001-5 2015 The enzyme kinetic studies, using Lineweaver-Burk indicated that, in the presence of the hydroxytyrosol, the Michaelis-Menton constant (Km) remained constant but the maximal velocity (Vmax) decreased, revealing a non-competitive type of inhibition with inhibition constants; Ki for the formation of the inhibitor-enzyme complex and Kis for the formation of the inhibitor-enzyme-substrate complex of 104.3 and 150.1 muM, respectively. 3,4-dihydroxyphenylethanol 89-103 U2AF homology motif kinase 1 Homo sapiens 332-335 26235001-5 2015 The enzyme kinetic studies, using Lineweaver-Burk indicated that, in the presence of the hydroxytyrosol, the Michaelis-Menton constant (Km) remained constant but the maximal velocity (Vmax) decreased, revealing a non-competitive type of inhibition with inhibition constants; Ki for the formation of the inhibitor-enzyme complex and Kis for the formation of the inhibitor-enzyme-substrate complex of 104.3 and 150.1 muM, respectively. 3,4-dihydroxyphenylethanol 89-103 latexin Homo sapiens 415-418 26235001-8 2015 However, at 600 muM, the hydroxytyrosol significantly decreased viability of the Caco-2 cells (p < 0.05) and in the case of the oleuropein, there"s an increase in cell number compared to control (p < 0.05). 3,4-dihydroxyphenylethanol 25-39 latexin Homo sapiens 16-19 26235001-9 2015 These results suggest that the hydroxytyrosol and oleuropein are two potential effective alpha-glucosidase inhibitors for management of postprandial hyperglycemia. 3,4-dihydroxyphenylethanol 31-45 sucrase-isomaltase Homo sapiens 89-106 24680823-0 2014 Influence of olive-derived hydroxytyrosol on the toll-like receptor 4-dependent inflammatory response of mouse peritoneal macrophages. 3,4-dihydroxyphenylethanol 27-41 toll-like receptor 4 Mus musculus 49-69 25072818-5 2014 This increase was accompanied by an increase in the extracellular level of homovanillic alcohol, a metabolite of hydroxytyrosol formed by catechol-O-methyltransferase activity. 3,4-dihydroxyphenylethanol 113-127 catechol-O-methyltransferase Rattus norvegicus 138-166 25072818-10 2014 Accordingly, there is high cerebral metabolism of hydroxytyrosol to produce homovanillic alcohol by catechol-O-methyltransferase activity, that is saturated at the higher administered dose of hydroxytyrosol. 3,4-dihydroxyphenylethanol 50-64 catechol-O-methyltransferase Rattus norvegicus 100-128 25072818-10 2014 Accordingly, there is high cerebral metabolism of hydroxytyrosol to produce homovanillic alcohol by catechol-O-methyltransferase activity, that is saturated at the higher administered dose of hydroxytyrosol. 3,4-dihydroxyphenylethanol 192-206 catechol-O-methyltransferase Rattus norvegicus 100-128 24691968-0 2014 Hydroxytyrosol inhibits chemokine C-C motif ligand 5 mediated aged quiescent fibroblast-induced stimulation of breast cancer cell proliferation. 3,4-dihydroxyphenylethanol 0-14 C-C motif chemokine ligand 5 Homo sapiens 24-52 24691968-9 2014 Hydroxytyrosol, a dietary polyphenol and an active ingredient of olive, inhibited CCL5 expression in aging quiescent NHFs. 3,4-dihydroxyphenylethanol 0-14 C-C motif chemokine ligand 5 Homo sapiens 82-86 25308544-5 2014 Alperujo and hydroxytyrosol also exhibited notable antiproliferative and caspase 3-dependent proapoptotic effects toward the human tumoral cell line HL60. 3,4-dihydroxyphenylethanol 13-27 caspase 3 Homo sapiens 73-82 24486741-0 2014 Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways. 3,4-dihydroxyphenylethanol 0-14 AKT serine/threonine kinase 1 Homo sapiens 130-133 24486741-0 2014 Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways. 3,4-dihydroxyphenylethanol 0-14 nuclear factor kappa B subunit 1 Homo sapiens 138-160 24389246-5 2014 Hydroxytyrosol prevented the decline in the expression of the PGC-1alpha transcription cascade of OXPHOS complexes in serum-starved fibroblast cultures. 3,4-dihydroxyphenylethanol 0-14 PPARG coactivator 1 alpha Homo sapiens 62-72 24066302-0 2013 Combined treatment of hydroxytyrosol with carbon monoxide-releasing molecule-2 prevents TNF alpha-induced vascular endothelial cell dysfunction through NO production with subsequent NFkappaB inactivation. 3,4-dihydroxyphenylethanol 22-36 tumor necrosis factor Homo sapiens 88-97 24246683-3 2014 Hydroxytyrosol is an orally bioavailable polyphenol, obtained from olives, which inhibits NF-kappabeta activity and has elicited promising efficacy signals in several inflammatory diseases. 3,4-dihydroxyphenylethanol 0-14 nuclear factor kappa B subunit 1 Homo sapiens 90-102 24401212-0 2014 Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCalpha and PKCbeta1 inhibition. 3,4-dihydroxyphenylethanol 0-14 matrix metallopeptidase 9 Homo sapiens 26-31 24401212-0 2014 Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCalpha and PKCbeta1 inhibition. 3,4-dihydroxyphenylethanol 0-14 mitochondrially encoded cytochrome c oxidase II Homo sapiens 36-41 24401212-0 2014 Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCalpha and PKCbeta1 inhibition. 3,4-dihydroxyphenylethanol 0-14 protein kinase C alpha Homo sapiens 99-107 24205178-4 2013 Therefore, a novel LC-MS methodology was developed and validated for the simultaneous quantification of OE and its main degradation product, hydroxytyrosol (HT), for the relevant OE claimed HMP"s. 3,4-dihydroxyphenylethanol 141-155 inner membrane mitochondrial protein Homo sapiens 190-193 23597197-9 2013 Moreover, addition of ROS scavengers (i.e. NAC, catalase, pyruvate, SOD) in the growth media can prevent hydroxytyrosol induced cell viability loss, suggesting that extracellular ROS (superoxide and hydrogen peroxide) facilitate the anti-proliferation effect of hydroxytyrosol in prostate cancer cells. 3,4-dihydroxyphenylethanol 105-119 catalase Homo sapiens 48-56 23292926-0 2013 3,4 dihydroxyphenyl ethanol reduces secretion of angiogenin in human retinal pigment epithelial cells. 3,4-dihydroxyphenylethanol 0-27 angiogenin Homo sapiens 49-59 23995352-9 2014 Pretreatment with a PKA inhibitor (Rp-cAMPs) and an ERK1/2 inhibitor (U0126) significantly attenuated hydroxytyrosol-stimulated lipolysis. 3,4-dihydroxyphenylethanol 102-116 mitogen-activated protein kinase 3 Homo sapiens 52-58 23995352-11 2014 Over the same range of concentrations, hydroxytyrosol downregulated the expression of adipose triglyceride lipase, hormone sensitive lipase (HSL), and adipogenesis-related transcription factors PPARgamma and C/EBPalpha. 3,4-dihydroxyphenylethanol 39-53 patatin like phospholipase domain containing 2 Homo sapiens 86-113 23995352-11 2014 Over the same range of concentrations, hydroxytyrosol downregulated the expression of adipose triglyceride lipase, hormone sensitive lipase (HSL), and adipogenesis-related transcription factors PPARgamma and C/EBPalpha. 3,4-dihydroxyphenylethanol 39-53 lipase E, hormone sensitive type Homo sapiens 115-139 23995352-11 2014 Over the same range of concentrations, hydroxytyrosol downregulated the expression of adipose triglyceride lipase, hormone sensitive lipase (HSL), and adipogenesis-related transcription factors PPARgamma and C/EBPalpha. 3,4-dihydroxyphenylethanol 39-53 lipase E, hormone sensitive type Homo sapiens 141-144 23995352-11 2014 Over the same range of concentrations, hydroxytyrosol downregulated the expression of adipose triglyceride lipase, hormone sensitive lipase (HSL), and adipogenesis-related transcription factors PPARgamma and C/EBPalpha. 3,4-dihydroxyphenylethanol 39-53 peroxisome proliferator activated receptor gamma Homo sapiens 194-203 23995352-11 2014 Over the same range of concentrations, hydroxytyrosol downregulated the expression of adipose triglyceride lipase, hormone sensitive lipase (HSL), and adipogenesis-related transcription factors PPARgamma and C/EBPalpha. 3,4-dihydroxyphenylethanol 39-53 CCAAT enhancer binding protein alpha Homo sapiens 208-218 23995352-12 2014 In addition, hydroxytyrosol increased the phosphorylation rate of HSL at Ser563 and Ser660, as well as perilipin and ERK phosphorylation. 3,4-dihydroxyphenylethanol 13-27 lipase E, hormone sensitive type Homo sapiens 66-69 23995352-12 2014 In addition, hydroxytyrosol increased the phosphorylation rate of HSL at Ser563 and Ser660, as well as perilipin and ERK phosphorylation. 3,4-dihydroxyphenylethanol 13-27 perilipin 1 Homo sapiens 103-112 23995352-13 2014 CONCLUSION: Hydroxytyrosol induced lipolysis in 3T3-L1 adipocytes via the activation of PKA and ERK1/2 pathway. 3,4-dihydroxyphenylethanol 12-26 mitogen-activated protein kinase 3 Homo sapiens 96-102 24019118-0 2014 Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells. 3,4-dihydroxyphenylethanol 15-29 G protein-coupled estrogen receptor 1 Homo sapiens 39-43 24019118-0 2014 Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells. 3,4-dihydroxyphenylethanol 15-29 G protein-coupled estrogen receptor 1 Homo sapiens 45-50 24019118-0 2014 Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells. 3,4-dihydroxyphenylethanol 15-29 estrogen receptor 1 Homo sapiens 41-43 24019118-1 2014 SCOPE: We have previously demonstrated that oleuropein (OL) and hydroxytyrosol (HT) reduce 17beta-estradiol-mediated proliferation in MCF-7 breast cancer (BC) cells without affecting the classical genomic action of estrogen receptor (ER), but activating instead the ERK1/2 pathway. 3,4-dihydroxyphenylethanol 64-78 estrogen receptor 1 Homo sapiens 234-236 24019118-1 2014 SCOPE: We have previously demonstrated that oleuropein (OL) and hydroxytyrosol (HT) reduce 17beta-estradiol-mediated proliferation in MCF-7 breast cancer (BC) cells without affecting the classical genomic action of estrogen receptor (ER), but activating instead the ERK1/2 pathway. 3,4-dihydroxyphenylethanol 64-78 mitogen-activated protein kinase 3 Homo sapiens 266-272 25460732-9 2014 Moreover, we observed that high glucose and free fatty acids reduced NO and increased ET-1 levels induced by acetylcholine through the modulation of intracellular calcium concentrations and endothelial NO synthase phosphorylation, events also reverted by hydroxytyrosol and polyphenol extract. 3,4-dihydroxyphenylethanol 255-269 endothelin 1 Homo sapiens 86-90 22680639-0 2012 Anti-inflammatory effect of 3,4-DHPEA-EDA [2-(3,4 -hydroxyphenyl) ethyl (3S, 4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate] on primary human vascular endothelial cells. 3,4-dihydroxyphenylethanol 28-37 ectodysplasin A Homo sapiens 38-41 22735309-8 2012 We suggest that hydroxytyrosol (HYD) could be a potential bioactive metabolite of PPGs since HYD, in equimolar amounts to PGGs, is able to both activate HO-1 transcription and modify Nrf2/Bach1 nuclear protein levels. 3,4-dihydroxyphenylethanol 16-30 NFE2 like bZIP transcription factor 2 Homo sapiens 183-187 22735309-8 2012 We suggest that hydroxytyrosol (HYD) could be a potential bioactive metabolite of PPGs since HYD, in equimolar amounts to PGGs, is able to both activate HO-1 transcription and modify Nrf2/Bach1 nuclear protein levels. 3,4-dihydroxyphenylethanol 16-30 BTB domain and CNC homolog 1 Homo sapiens 188-193 21805082-2 2012 The aim of this study was to clarify the role played by H2O2 in the chemopreventive activities of 3,4-DHPEA on breast (MDA and MCF-7), prostate (LNCap and PC3) and colon (SW480 and HCT116) cancer cell lines and to investigate the effects of cell culture medium components and the possible mechanisms at the basis of the H2O2-producing properties of 3,4-DHPEA. 3,4-dihydroxyphenylethanol 98-107 chromobox 8 Homo sapiens 155-158 21937211-0 2012 Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways. 3,4-dihydroxyphenylethanol 78-92 sequestosome 1 Homo sapiens 167-173 21384152-0 2012 MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. 3,4-dihydroxyphenylethanol 25-39 superoxide dismutase 2 Homo sapiens 0-5 22236145-10 2012 Additional mechanistic cell culture experiments were performed, and they suggest that the olive oil phenolic hydroxytyrosol present in the HP oil may be responsible for the induction of Nrf2-dependent gene expression and the increase in PON activity. 3,4-dihydroxyphenylethanol 109-123 nuclear factor, erythroid derived 2, like 2 Mus musculus 186-190 22680639-8 2012 These results point on the use of 3,4- DHPEA-EDA as a novel drug aimed to prevent or reduce inflammation of endothelium. 3,4-dihydroxyphenylethanol 34-44 ectodysplasin A Homo sapiens 45-48 22680639-5 2012 Pre-treatment of cells with 3,4-DHPEA-EDA resulted in a dose-dependent inhibition of CCL2 secretion. 3,4-dihydroxyphenylethanol 28-37 ectodysplasin A Homo sapiens 38-41 22680639-5 2012 Pre-treatment of cells with 3,4-DHPEA-EDA resulted in a dose-dependent inhibition of CCL2 secretion. 3,4-dihydroxyphenylethanol 28-37 C-C motif chemokine ligand 2 Homo sapiens 85-89 22680639-6 2012 The effect of 3,4-DHPEA-EDA on CCL2 expression was observed at the transcriptional level. 3,4-dihydroxyphenylethanol 14-23 ectodysplasin A Homo sapiens 24-27 22680639-6 2012 The effect of 3,4-DHPEA-EDA on CCL2 expression was observed at the transcriptional level. 3,4-dihydroxyphenylethanol 14-23 C-C motif chemokine ligand 2 Homo sapiens 31-35 22680639-7 2012 Functional data have shown that 3,4-DHPEA-EDA diminished monocyte adhesion to HUVECs. 3,4-dihydroxyphenylethanol 32-41 ectodysplasin A Homo sapiens 42-45 22114936-5 2011 In LPS-stimulated peritoneal macrophages, the oleuropein metabolite, hydroxytyrosol, was shown to inhibit NO production, iNOS expression, NF-kappaB p65 subunit translocation, mRNA expression, and the release of IL-1beta, IL-6, and TNF-alpha. 3,4-dihydroxyphenylethanol 69-83 nitric oxide synthase 2, inducible Mus musculus 121-125 22114936-5 2011 In LPS-stimulated peritoneal macrophages, the oleuropein metabolite, hydroxytyrosol, was shown to inhibit NO production, iNOS expression, NF-kappaB p65 subunit translocation, mRNA expression, and the release of IL-1beta, IL-6, and TNF-alpha. 3,4-dihydroxyphenylethanol 69-83 interleukin 6 Mus musculus 221-225 22114936-5 2011 In LPS-stimulated peritoneal macrophages, the oleuropein metabolite, hydroxytyrosol, was shown to inhibit NO production, iNOS expression, NF-kappaB p65 subunit translocation, mRNA expression, and the release of IL-1beta, IL-6, and TNF-alpha. 3,4-dihydroxyphenylethanol 69-83 interleukin 1 beta Mus musculus 211-219 22114936-5 2011 In LPS-stimulated peritoneal macrophages, the oleuropein metabolite, hydroxytyrosol, was shown to inhibit NO production, iNOS expression, NF-kappaB p65 subunit translocation, mRNA expression, and the release of IL-1beta, IL-6, and TNF-alpha. 3,4-dihydroxyphenylethanol 69-83 tumor necrosis factor Mus musculus 231-240 21411025-3 2011 Both 3,4-DHPEA-EDA and 3,4-DHPEA-EA were relatively stable under gastric conditions, only undergoing limited hydrolysis. 3,4-dihydroxyphenylethanol 5-14 ectodysplasin A Homo sapiens 15-18 21945192-8 2011 PPARgamma, C/EBPalpha and SREBP-1c transcription factors and their downstream targets genes (GLUT4, CD36 and FASN) were down-regulated after treatment by oleuropein and hydroxytyrosol. 3,4-dihydroxyphenylethanol 169-183 sterol regulatory element binding transcription factor 1 Mus musculus 26-34 21945192-11 2011 Furthermore, oleuropein and its derivate hydroxytyrosol decreased the transcriptional activity of SREBP-1c in a stable transfected 3T3-L1 cell line. 3,4-dihydroxyphenylethanol 41-55 sterol regulatory element binding transcription factor 1 Mus musculus 98-106 21590650-0 2011 Hydroxytyrosol induces vascular smooth muscle cells apoptosis through NO production and PP2A activation with subsequent inactivation of Akt. 3,4-dihydroxyphenylethanol 0-14 AKT serine/threonine kinase 1 Homo sapiens 136-139 21910448-0 2011 Comment on hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction. 3,4-dihydroxyphenylethanol 11-25 NFE2 like bZIP transcription factor 2 Homo sapiens 131-135 21569430-13 2011 DHA, beta-carotene and hydroxytyrosol inhibited the gene expression of PPARgamma, C/EBPalpha, aP2 and CPT-1beta. 3,4-dihydroxyphenylethanol 23-37 peroxisome proliferator activated receptor gamma Mus musculus 71-80 21438539-0 2011 Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction. 3,4-dihydroxyphenylethanol 0-14 NFE2 like bZIP transcription factor 2 Homo sapiens 120-124 21569430-13 2011 DHA, beta-carotene and hydroxytyrosol inhibited the gene expression of PPARgamma, C/EBPalpha, aP2 and CPT-1beta. 3,4-dihydroxyphenylethanol 23-37 carnitine palmitoyltransferase 1b, muscle Mus musculus 102-111 21569430-13 2011 DHA, beta-carotene and hydroxytyrosol inhibited the gene expression of PPARgamma, C/EBPalpha, aP2 and CPT-1beta. 3,4-dihydroxyphenylethanol 23-37 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 82-92 21569430-13 2011 DHA, beta-carotene and hydroxytyrosol inhibited the gene expression of PPARgamma, C/EBPalpha, aP2 and CPT-1beta. 3,4-dihydroxyphenylethanol 23-37 transcription factor AP-2, alpha Mus musculus 94-97 20601268-1 2011 Phenylalkanols such as tyrosol and hydroxytyrosol (h-tyrosol), which possess antioxidant and anticancer properties, were phosphatidylated by phospholipase D (PLD)-catalyzed transphosphatidylation. 3,4-dihydroxyphenylethanol 35-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 141-156 21120994-0 2011 Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours. 3,4-dihydroxyphenylethanol 0-14 secreted frizzled-related protein 4 Rattus norvegicus 86-91 21120994-9 2011 Moreover, hydroxytyrosol alters several genes associated with cell proliferation, apoptosis and the Wnt signalling pathway, promoting a high expression of Sfrp4. 3,4-dihydroxyphenylethanol 10-24 secreted frizzled-related protein 4 Rattus norvegicus 155-160 20601268-1 2011 Phenylalkanols such as tyrosol and hydroxytyrosol (h-tyrosol), which possess antioxidant and anticancer properties, were phosphatidylated by phospholipase D (PLD)-catalyzed transphosphatidylation. 3,4-dihydroxyphenylethanol 35-49 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 158-161 20601268-1 2011 Phenylalkanols such as tyrosol and hydroxytyrosol (h-tyrosol), which possess antioxidant and anticancer properties, were phosphatidylated by phospholipase D (PLD)-catalyzed transphosphatidylation. 3,4-dihydroxyphenylethanol 51-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 141-156 20601268-1 2011 Phenylalkanols such as tyrosol and hydroxytyrosol (h-tyrosol), which possess antioxidant and anticancer properties, were phosphatidylated by phospholipase D (PLD)-catalyzed transphosphatidylation. 3,4-dihydroxyphenylethanol 51-60 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 158-161 20166143-0 2010 Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells. 3,4-dihydroxyphenylethanol 0-14 NFE2 like bZIP transcription factor 2 Homo sapiens 60-64 20149621-5 2010 Hydroxytyrosol treatment simultaneously protected against acrolein-induced inhibition of nuclear factor-E2-related factor 2 (Nrf2) and peroxisome proliferator-activated receptor coactivator 1 alpha (PPARGC1alpha) in ARPE-19 cells. 3,4-dihydroxyphenylethanol 0-14 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 20149621-5 2010 Hydroxytyrosol treatment simultaneously protected against acrolein-induced inhibition of nuclear factor-E2-related factor 2 (Nrf2) and peroxisome proliferator-activated receptor coactivator 1 alpha (PPARGC1alpha) in ARPE-19 cells. 3,4-dihydroxyphenylethanol 0-14 PPARG coactivator 1 alpha Homo sapiens 199-211 20166143-0 2010 Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells. 3,4-dihydroxyphenylethanol 0-14 protein tyrosine kinase 2 beta Homo sapiens 149-165 18848665-5 2008 RESULTS: Hydroxytyrosol pronouncedly increased norepinephrine transporter activity, with the rapid onset excluding effects on norepinephrine transporter expression levels. 3,4-dihydroxyphenylethanol 9-23 solute carrier family 6 member 2 Rattus norvegicus 47-73 20013881-0 2010 Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation. 3,4-dihydroxyphenylethanol 15-29 mitogen-activated protein kinase 3 Homo sapiens 94-100 19685549-0 2009 Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1. 3,4-dihydroxyphenylethanol 0-14 mitogen-activated protein kinase 3 Homo sapiens 100-106 19685549-0 2009 Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1. 3,4-dihydroxyphenylethanol 0-14 cyclin D1 Homo sapiens 111-120 19336887-0 2009 Suppressive effects of hydroxytyrosol on oxidative stress and nuclear Factor-kappaB activation in THP-1 cells. 3,4-dihydroxyphenylethanol 23-37 nuclear factor kappa B subunit 1 Homo sapiens 77-83 19336887-1 2009 This study was designed to investigate whether hydroxytyrosol (HT) may ameliorate oxidative stress and nuclear factor kappaB (NF-kappaB) activation in the lipopolysaccharide (LPS)-stimulated THP-1 cell line. 3,4-dihydroxyphenylethanol 47-61 nuclear factor kappa B subunit 1 Homo sapiens 118-124 19336887-1 2009 This study was designed to investigate whether hydroxytyrosol (HT) may ameliorate oxidative stress and nuclear factor kappaB (NF-kappaB) activation in the lipopolysaccharide (LPS)-stimulated THP-1 cell line. 3,4-dihydroxyphenylethanol 47-61 nuclear factor kappa B subunit 1 Homo sapiens 126-135 18848665-0 2008 Hydroxytyrosol increases norepinephrine transporter function in pheochromocytoma cells. 3,4-dihydroxyphenylethanol 0-14 solute carrier family 6 member 2 Rattus norvegicus 25-51 18848665-3 2008 The objective of the present study was to test the possible beneficial effects of hydroxytyrosol in enhancing norepinephrine transporter function, which may have implications for its combined use with (131)I-MIBG in the diagnosis and treatment of pheochromocytomas. 3,4-dihydroxyphenylethanol 82-96 solute carrier family 6 member 2 Rattus norvegicus 110-136 19198806-0 2009 Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. 3,4-dihydroxyphenylethanol 0-14 nitric oxide synthase 2 Homo sapiens 52-56 19198806-0 2009 Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. 3,4-dihydroxyphenylethanol 0-14 prostaglandin-endoperoxide synthase 2 Homo sapiens 62-67 19388687-4 2009 As a minor and compensatory metabolic pathway, DOPAL can be reduced to 3,4-dihydroxyphenylethanol (DOPET) via cytosolic aldehyde or aldose reductase (AR). 3,4-dihydroxyphenylethanol 71-97 aldo-keto reductase family 1 member B1 Rattus norvegicus 132-148 19388687-4 2009 As a minor and compensatory metabolic pathway, DOPAL can be reduced to 3,4-dihydroxyphenylethanol (DOPET) via cytosolic aldehyde or aldose reductase (AR). 3,4-dihydroxyphenylethanol 71-97 aldo-keto reductase family 1 member B1 Rattus norvegicus 150-152 18848665-5 2008 RESULTS: Hydroxytyrosol pronouncedly increased norepinephrine transporter activity, with the rapid onset excluding effects on norepinephrine transporter expression levels. 3,4-dihydroxyphenylethanol 9-23 solute carrier family 6 member 2 Rattus norvegicus 126-152 18848665-6 2008 Concomitant with increased norepinephrine transporter activity, hydroxytyrosol caused a decrease of both spontaneous and evoked norepinephrine release, indicating that it affects pre-existing plasma membrane-associated norepinephrine transporter, rather than the incorporation of novel norepinephrine transporter molecules into the plasma membrane. 3,4-dihydroxyphenylethanol 64-78 solute carrier family 6 member 2 Rattus norvegicus 219-245 18848665-6 2008 Concomitant with increased norepinephrine transporter activity, hydroxytyrosol caused a decrease of both spontaneous and evoked norepinephrine release, indicating that it affects pre-existing plasma membrane-associated norepinephrine transporter, rather than the incorporation of novel norepinephrine transporter molecules into the plasma membrane. 3,4-dihydroxyphenylethanol 64-78 solute carrier family 6 member 2 Rattus norvegicus 219-245 18848665-7 2008 CONCLUSION: Hydroxytyrosol potently enhances norepinephrine transporter activity in pheochromocytoma PC12 cells, suggesting that combinatorial therapy employing hydroxytyrosol may improve the effectiveness of (131)I-MIBG as a diagnosis and treatment modality. 3,4-dihydroxyphenylethanol 12-26 solute carrier family 6 member 2 Rattus norvegicus 45-71 18848665-7 2008 CONCLUSION: Hydroxytyrosol potently enhances norepinephrine transporter activity in pheochromocytoma PC12 cells, suggesting that combinatorial therapy employing hydroxytyrosol may improve the effectiveness of (131)I-MIBG as a diagnosis and treatment modality. 3,4-dihydroxyphenylethanol 161-175 solute carrier family 6 member 2 Rattus norvegicus 45-71 12763027-6 2003 Resveratrol and hydroxytyrosol, unexpectedly, amplified peroxynitrite-dependent upregulation of Band 3 tyrosine phosphorylation through the activation of lyn, a kinase of the src family. 3,4-dihydroxyphenylethanol 16-30 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 175-178 16873395-7 2006 However, hydroxytyrosol administration decreased apolipoprotein A-I and increased total cholesterol, atherosclerotic lesion areas and circulating monocytes expressing Mac-1. 3,4-dihydroxyphenylethanol 9-23 apolipoprotein A-I Mus musculus 49-67 16873395-7 2006 However, hydroxytyrosol administration decreased apolipoprotein A-I and increased total cholesterol, atherosclerotic lesion areas and circulating monocytes expressing Mac-1. 3,4-dihydroxyphenylethanol 9-23 integrin alpha M Mus musculus 167-172 15855205-10 2005 Both hydroxytyrosol and resveratrol strengthened the CsA induction of HO-1 expression. 3,4-dihydroxyphenylethanol 5-19 heme oxygenase 1 Rattus norvegicus 70-74 18156402-0 2008 Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells. 3,4-dihydroxyphenylethanol 40-54 cyclin dependent kinase inhibitor 1A Homo sapiens 133-136 18156402-0 2008 Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells. 3,4-dihydroxyphenylethanol 40-54 cyclin dependent kinase inhibitor 1A Homo sapiens 137-141 18156402-0 2008 Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells. 3,4-dihydroxyphenylethanol 40-54 cyclin dependent kinase inhibitor 1A Homo sapiens 142-146 18156402-0 2008 Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells. 3,4-dihydroxyphenylethanol 40-54 dynactin subunit 6 Homo sapiens 152-155 18156402-0 2008 Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells. 3,4-dihydroxyphenylethanol 40-54 cyclin dependent kinase inhibitor 1B Homo sapiens 156-160 18156402-7 2008 Among the different proteins involved in the regulation of the cell cycle, 3,4-DHPEA reduced the level of cyclin-dependent kinase (CDK) 6 and increased that of cyclin D3. 3,4-dihydroxyphenylethanol 75-84 cyclin dependent kinase 6 Homo sapiens 131-137 18156402-7 2008 Among the different proteins involved in the regulation of the cell cycle, 3,4-DHPEA reduced the level of cyclin-dependent kinase (CDK) 6 and increased that of cyclin D3. 3,4-dihydroxyphenylethanol 75-84 cyclin D3 Homo sapiens 160-169 17418557-7 2007 These results suggest that phenols except hydroxytyrosol in EV-olive oil enhance thermogenesis by increasing the UCP1 content in IBAT and enhancing noradrenaline and adrenaline secretions in rats. 3,4-dihydroxyphenylethanol 42-56 uncoupling protein 1 Rattus norvegicus 113-117 12207832-1 2002 Hydroxytyrosol, tyrosol and caffeic acid effects on hydrogen peroxide-induced DNA damage, hydroperoxide generation and redox enzyme gene expression were studied in oxidative-stress-sensitive human prostate cells (PC3). 3,4-dihydroxyphenylethanol 0-14 chromobox 8 Homo sapiens 213-216 12482581-3 2002 The expression profile of hydroxytyrosol-treated cells showed the up-regulation of several genes, including c-jun and egr1. 3,4-dihydroxyphenylethanol 26-40 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 108-113 12482581-3 2002 The expression profile of hydroxytyrosol-treated cells showed the up-regulation of several genes, including c-jun and egr1. 3,4-dihydroxyphenylethanol 26-40 early growth response 1 Homo sapiens 118-122 12482581-6 2002 All antioxidants up-regulate Erk1/2, while only hydroxytyrosol and pyrrolidine dithiocarbamate activate c-Jun N-terminal kinase (JNK). 3,4-dihydroxyphenylethanol 48-62 mitogen-activated protein kinase 8 Homo sapiens 104-127 12482581-6 2002 All antioxidants up-regulate Erk1/2, while only hydroxytyrosol and pyrrolidine dithiocarbamate activate c-Jun N-terminal kinase (JNK). 3,4-dihydroxyphenylethanol 48-62 mitogen-activated protein kinase 8 Homo sapiens 129-132 12482581-8 2002 Bcl-2 phosphorylation was increased by hydroxytyrosol and pyrrolidine dithiocarbamate and not by resveratrol. 3,4-dihydroxyphenylethanol 39-53 BCL2 apoptosis regulator Homo sapiens 0-5 10854571-2 2000 This aldehyde is mainly oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH), but is also partly reduced to 3, 4-dihydroxyphenylethanol (DOPET) by aldehyde or aldose reductase (ARs). 3,4-dihydroxyphenylethanol 139-166 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 102-106 11095977-0 2000 Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis. 3,4-dihydroxyphenylethanol 0-14 cytochrome c, somatic Homo sapiens 67-79 10958837-4 2000 Oleuropein glycoside, hydroxytyrosol, gallic acid and dihydroxybenzoic acid also inhibited reductive 17beta-HSD activity. 3,4-dihydroxyphenylethanol 22-36 hydroxysteroid 17-beta dehydrogenase 13 Homo sapiens 101-111 10854571-2 2000 This aldehyde is mainly oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH), but is also partly reduced to 3, 4-dihydroxyphenylethanol (DOPET) by aldehyde or aldose reductase (ARs). 3,4-dihydroxyphenylethanol 139-166 aldo-keto reductase family 1 member B1 Rattus norvegicus 190-206 10797558-2 2000 This aldehyde is either oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase, an NAD-dependent enzyme or reduced to 3, 4-dihydroxyphenylethanol (DOPET) by aldehyde or aldose reductase. 3,4-dihydroxyphenylethanol 140-167 aldo-keto reductase family 1 member B1 Rattus norvegicus 191-207 28711992-0 2017 Oleuropein and hydroxytyrosol inhibit the N-formyl-methionyl-leucyl-phenylalanine-induced neutrophil degranulation and chemotaxis via AKT, p38, and ERK1/2 MAP-Kinase inhibition. 3,4-dihydroxyphenylethanol 15-29 mitogen-activated protein kinase 1 Homo sapiens 139-142 28711992-0 2017 Oleuropein and hydroxytyrosol inhibit the N-formyl-methionyl-leucyl-phenylalanine-induced neutrophil degranulation and chemotaxis via AKT, p38, and ERK1/2 MAP-Kinase inhibition. 3,4-dihydroxyphenylethanol 15-29 mitogen-activated protein kinase 3 Homo sapiens 148-154 28711992-10 2017 RESULTS: We show that in addition to their ROS scavenging effect, oleuropein and hydroxytyrosol significantly inhibited the bacterial peptide N-formyl-methionyl-leucyl-phenylalanine (fMLF)-induced degranulation of azurophilic and specific granules as measured by myeloperoxidase and lactoferrin release, respectively. 3,4-dihydroxyphenylethanol 81-95 myeloperoxidase Homo sapiens 263-278 34509344-0 2022 Corrigendum to "Hydroxytyrosol prevents PM2.5-induced adiposity and insulin resistance by restraining oxidative stress related NF-kappaB pathway and modulation of gut microbiota in a murine model" (Free Radic. 3,4-dihydroxyphenylethanol 16-30 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 127-136 34890039-6 2021 Bioinformatic docking studies showed that alpha-cyclodextrin and hydroxytyrosol, alone or in combination, interact with the viral spike protein and its host cell receptor ACE2, thereby potentially influencing the endocytosis process. 3,4-dihydroxyphenylethanol 65-79 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 130-135 34890039-6 2021 Bioinformatic docking studies showed that alpha-cyclodextrin and hydroxytyrosol, alone or in combination, interact with the viral spike protein and its host cell receptor ACE2, thereby potentially influencing the endocytosis process. 3,4-dihydroxyphenylethanol 65-79 angiotensin converting enzyme 2 Homo sapiens 171-175 34126350-2 2021 The aim of this study is to elucidate the effects and the underlying mechanisms of hydroxytyrosol and oleuropein on the tumor necrosis factor-alpha (TNF-alpha)-induced macrophage colony-stimulating factor (M-CSF) and interleukin-6 (IL-6) synthesis in osteoblasts. 3,4-dihydroxyphenylethanol 83-97 tumor necrosis factor Mus musculus 149-158 34610362-8 2021 HT inhibited osteoclast differentiation and prevented OS induced pre-osteoblast cells injury via regulating mitochondrial function as well as ERK and JNK signaling pathways. 3,4-dihydroxyphenylethanol 0-2 mitogen-activated protein kinase 1 Mus musculus 142-145 34610362-8 2021 HT inhibited osteoclast differentiation and prevented OS induced pre-osteoblast cells injury via regulating mitochondrial function as well as ERK and JNK signaling pathways. 3,4-dihydroxyphenylethanol 0-2 mitogen-activated protein kinase 8 Mus musculus 150-153 34358533-3 2021 Phytochemicals exhibit biphasic dose responses on cancer cells, activating at low dose, signaling pathways resulting in upregulation of vitagenes, as in the case of the Nrf2 pathway upregulated by hydroxytyrosol (HT) or curcumin and NAD/NADH-sirtuin-1 activated by resveratrol. 3,4-dihydroxyphenylethanol 197-211 NFE2 like bZIP transcription factor 2 Homo sapiens 169-173 34358533-3 2021 Phytochemicals exhibit biphasic dose responses on cancer cells, activating at low dose, signaling pathways resulting in upregulation of vitagenes, as in the case of the Nrf2 pathway upregulated by hydroxytyrosol (HT) or curcumin and NAD/NADH-sirtuin-1 activated by resveratrol. 3,4-dihydroxyphenylethanol 197-211 sirtuin 1 Homo sapiens 242-251 34358533-3 2021 Phytochemicals exhibit biphasic dose responses on cancer cells, activating at low dose, signaling pathways resulting in upregulation of vitagenes, as in the case of the Nrf2 pathway upregulated by hydroxytyrosol (HT) or curcumin and NAD/NADH-sirtuin-1 activated by resveratrol. 3,4-dihydroxyphenylethanol 213-215 NFE2 like bZIP transcription factor 2 Homo sapiens 169-173 34126350-11 2021 Hydroxytyrosol suppressed the TNF-alpha-induced mRNA expressions of M-CSF and IL-6. 3,4-dihydroxyphenylethanol 0-14 tumor necrosis factor Mus musculus 30-39 34126350-11 2021 Hydroxytyrosol suppressed the TNF-alpha-induced mRNA expressions of M-CSF and IL-6. 3,4-dihydroxyphenylethanol 0-14 colony stimulating factor 1 (macrophage) Mus musculus 68-73 34126350-11 2021 Hydroxytyrosol suppressed the TNF-alpha-induced mRNA expressions of M-CSF and IL-6. 3,4-dihydroxyphenylethanol 0-14 interleukin 6 Mus musculus 78-82 34858184-8 2021 Moreover, HT enhanced the anti-tumor effect of anti-CD47 antibody in vivo. 3,4-dihydroxyphenylethanol 10-12 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 52-56 34769070-5 2021 Whole-transcriptome profiling of HTOL-treated MM cells, coupled with protein expression analyses, indicate that HTOL antagonizes key survival pathways for malignant plasma cells, including the undruggable IRF4-c-MYC oncogenic axis. 3,4-dihydroxyphenylethanol 33-37 MYC proto-oncogene, bHLH transcription factor Homo sapiens 212-215 34769070-5 2021 Whole-transcriptome profiling of HTOL-treated MM cells, coupled with protein expression analyses, indicate that HTOL antagonizes key survival pathways for malignant plasma cells, including the undruggable IRF4-c-MYC oncogenic axis. 3,4-dihydroxyphenylethanol 112-116 MYC proto-oncogene, bHLH transcription factor Homo sapiens 212-215 34769070-6 2021 Accordingly, c-MYC gain- and loss-of-function strategies demonstrate that HTOL anti-tumor activity was, at least in part, due to c-MYC targeting. 3,4-dihydroxyphenylethanol 74-78 MYC proto-oncogene, bHLH transcription factor Homo sapiens 13-18 34769070-6 2021 Accordingly, c-MYC gain- and loss-of-function strategies demonstrate that HTOL anti-tumor activity was, at least in part, due to c-MYC targeting. 3,4-dihydroxyphenylethanol 74-78 MYC proto-oncogene, bHLH transcription factor Homo sapiens 129-134 34126350-2 2021 The aim of this study is to elucidate the effects and the underlying mechanisms of hydroxytyrosol and oleuropein on the tumor necrosis factor-alpha (TNF-alpha)-induced macrophage colony-stimulating factor (M-CSF) and interleukin-6 (IL-6) synthesis in osteoblasts. 3,4-dihydroxyphenylethanol 83-97 colony stimulating factor 1 (macrophage) Mus musculus 206-211 34126350-2 2021 The aim of this study is to elucidate the effects and the underlying mechanisms of hydroxytyrosol and oleuropein on the tumor necrosis factor-alpha (TNF-alpha)-induced macrophage colony-stimulating factor (M-CSF) and interleukin-6 (IL-6) synthesis in osteoblasts. 3,4-dihydroxyphenylethanol 83-97 interleukin 6 Mus musculus 232-236 34126350-7 2021 RESULTS: Hydroxytyrosol and oleuropein attenuated the TNF-alpha-stimulated M-CSF release. 3,4-dihydroxyphenylethanol 9-23 tumor necrosis factor Mus musculus 54-63 34126350-7 2021 RESULTS: Hydroxytyrosol and oleuropein attenuated the TNF-alpha-stimulated M-CSF release. 3,4-dihydroxyphenylethanol 9-23 colony stimulating factor 1 (macrophage) Mus musculus 75-80 34126350-9 2021 Hydroxytyrosol and oleuropein suppressed the TNF-alpha-induced phosphorylation of Akt and p44/p42 MAP kinase. 3,4-dihydroxyphenylethanol 0-14 tumor necrosis factor Mus musculus 45-54 34126350-9 2021 Hydroxytyrosol and oleuropein suppressed the TNF-alpha-induced phosphorylation of Akt and p44/p42 MAP kinase. 3,4-dihydroxyphenylethanol 0-14 thymoma viral proto-oncogene 1 Mus musculus 82-85 34126350-9 2021 Hydroxytyrosol and oleuropein suppressed the TNF-alpha-induced phosphorylation of Akt and p44/p42 MAP kinase. 3,4-dihydroxyphenylethanol 0-14 mitogen-activated protein kinase 3 Mus musculus 90-93 34126350-9 2021 Hydroxytyrosol and oleuropein suppressed the TNF-alpha-induced phosphorylation of Akt and p44/p42 MAP kinase. 3,4-dihydroxyphenylethanol 0-14 cyclin-dependent kinase 20 Mus musculus 94-97 34126350-10 2021 Hydroxytyrosol and oleuropein attenuated the TNF-alpha-stimulated IL-6 release. 3,4-dihydroxyphenylethanol 0-14 tumor necrosis factor Mus musculus 45-54 34126350-10 2021 Hydroxytyrosol and oleuropein attenuated the TNF-alpha-stimulated IL-6 release. 3,4-dihydroxyphenylethanol 0-14 interleukin 6 Mus musculus 66-70 34065584-7 2021 Form a molecular point of view, hydroxytyrosol is able to preserve the cellular redox balance and protein homeostasis by activating the Nrf2 pathway and increasing the expression of phase II detoxifying enzymes such as HO-1, SOD, Catalase, and GSH, thus counteracting the neurodegenerative damage. 3,4-dihydroxyphenylethanol 32-46 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 34356366-5 2021 Oleuropein, oleacein, oleocanthal, hydroxytyrosol, and tyrosol, tested alone, reduced the DPP-IV activity, with IC50 of 472.3 +- 21.7, 187 +- 11.4, 354.5 +- 12.7, 741.6 +- 35.7, and 1112 +- 55.6 microM, respectively. 3,4-dihydroxyphenylethanol 35-49 dipeptidyl peptidase 4 Homo sapiens 90-96 34199427-4 2021 In vitro, 3,4-dihydroxyphenylacetaldehyde (DOPAL) and the other two metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and 3,4-dihydroxyphenylethanol (DOPET), share the property to inhibit the growth of mature amyloid fibrils of alpha-synuclein. 3,4-dihydroxyphenylethanol 124-150 synuclein alpha Homo sapiens 230-245 34199427-4 2021 In vitro, 3,4-dihydroxyphenylacetaldehyde (DOPAL) and the other two metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and 3,4-dihydroxyphenylethanol (DOPET), share the property to inhibit the growth of mature amyloid fibrils of alpha-synuclein. 3,4-dihydroxyphenylethanol 152-157 synuclein alpha Homo sapiens 230-245 34149875-0 2021 Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation. 3,4-dihydroxyphenylethanol 13-27 thioredoxin reductase 1 Homo sapiens 31-54 34149875-3 2021 The present study revealed that the natural product hydroxytyrosol (HT), which exhibits a polyphenol scaffold, is a potent inhibitor of TrxR1. 3,4-dihydroxyphenylethanol 52-66 thioredoxin reductase 1 Homo sapiens 136-141 34149875-3 2021 The present study revealed that the natural product hydroxytyrosol (HT), which exhibits a polyphenol scaffold, is a potent inhibitor of TrxR1. 3,4-dihydroxyphenylethanol 68-70 thioredoxin reductase 1 Homo sapiens 136-141 34360703-7 2021 Some (poly)phenolics such as caffeic acid, hydroxytyrosol, resveratrol, curcumin, nordihydroguaiaretic acid (NDGA), and quercetin have been reported to reduce the formation of 5-LOX eicosanoids in vitro. 3,4-dihydroxyphenylethanol 43-57 arachidonate 5-lipoxygenase Homo sapiens 176-181 34356360-0 2021 Hydroxytyrosol Selectively Affects Non-Enzymatic Glycation in Human Insulin and Protects by AGEs Cytotoxicity. 3,4-dihydroxyphenylethanol 0-14 insulin Homo sapiens 68-75 34162164-0 2021 Hydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. 3,4-dihydroxyphenylethanol 0-14 CKLF-like MARVEL transmembrane domain containing 2A Mus musculus 81-86 34162164-10 2021 Our results demonstrated that HT protected CDDP-induced renal injury through inhibiting CKLF1 mediated inflammatory pathway, and also by anti-oxidative stress and anti-apoptosis. 3,4-dihydroxyphenylethanol 30-32 CKLF-like MARVEL transmembrane domain containing 2A Mus musculus 88-93 34065584-7 2021 Form a molecular point of view, hydroxytyrosol is able to preserve the cellular redox balance and protein homeostasis by activating the Nrf2 pathway and increasing the expression of phase II detoxifying enzymes such as HO-1, SOD, Catalase, and GSH, thus counteracting the neurodegenerative damage. 3,4-dihydroxyphenylethanol 32-46 heme oxygenase 1 Homo sapiens 219-223 34065584-7 2021 Form a molecular point of view, hydroxytyrosol is able to preserve the cellular redox balance and protein homeostasis by activating the Nrf2 pathway and increasing the expression of phase II detoxifying enzymes such as HO-1, SOD, Catalase, and GSH, thus counteracting the neurodegenerative damage. 3,4-dihydroxyphenylethanol 32-46 superoxide dismutase 1 Homo sapiens 225-228 34065584-7 2021 Form a molecular point of view, hydroxytyrosol is able to preserve the cellular redox balance and protein homeostasis by activating the Nrf2 pathway and increasing the expression of phase II detoxifying enzymes such as HO-1, SOD, Catalase, and GSH, thus counteracting the neurodegenerative damage. 3,4-dihydroxyphenylethanol 32-46 catalase Homo sapiens 230-238 35229750-0 2022 Hydroxytyrosol (2-(3,4-dihydroxyphenyl)-ethanol), a natural phenolic compound found in the olive, alters Ca2+ signaling and viability in human HepG2 hepatoma cells. 3,4-dihydroxyphenylethanol 0-14 carbonic anhydrase 2 Homo sapiens 105-108 35248848-0 2022 Hydroxytyrosol alleviates dextran sodium sulfate-induced colitis by inhibiting NLRP3 inflammasome activation and modulating gut microbiota in vivo. 3,4-dihydroxyphenylethanol 0-14 NLR family, pyrin domain containing 3 Mus musculus 79-84 35206003-0 2022 Anti-VEGF Effect of Bioactive Indolic Compounds and Hydroxytyrosol Metabolites. 3,4-dihydroxyphenylethanol 52-66 vascular endothelial growth factor A Homo sapiens 5-9 35206003-2 2022 The aim of this study was to determine the molecular mechanism underlying the potent inhibition of VEGF signaling by hydroxytyrosol (HT) metabolites and indolic compounds and establish a relation between their structure and bioactivity. 3,4-dihydroxyphenylethanol 117-131 vascular endothelial growth factor A Homo sapiens 99-103 35206003-2 2022 The aim of this study was to determine the molecular mechanism underlying the potent inhibition of VEGF signaling by hydroxytyrosol (HT) metabolites and indolic compounds and establish a relation between their structure and bioactivity. 3,4-dihydroxyphenylethanol 133-135 vascular endothelial growth factor A Homo sapiens 99-103 34525916-5 2022 Data reported for hydroxytyrosol suggest that the activation of the hepatic PPAR-alpha-FGF21-AMPK-PGC-1alpha signaling cascade is associated with fatty acid oxidation enhancement, de novo lipogenesis diminution and recovery of mitochondrial function, a contention that is supported by the actions of several polyphenols on specific components of this signaling pathway. 3,4-dihydroxyphenylethanol 18-32 peroxisome proliferator activated receptor alpha Homo sapiens 76-86 34525916-5 2022 Data reported for hydroxytyrosol suggest that the activation of the hepatic PPAR-alpha-FGF21-AMPK-PGC-1alpha signaling cascade is associated with fatty acid oxidation enhancement, de novo lipogenesis diminution and recovery of mitochondrial function, a contention that is supported by the actions of several polyphenols on specific components of this signaling pathway. 3,4-dihydroxyphenylethanol 18-32 fibroblast growth factor 21 Homo sapiens 87-92 34525916-5 2022 Data reported for hydroxytyrosol suggest that the activation of the hepatic PPAR-alpha-FGF21-AMPK-PGC-1alpha signaling cascade is associated with fatty acid oxidation enhancement, de novo lipogenesis diminution and recovery of mitochondrial function, a contention that is supported by the actions of several polyphenols on specific components of this signaling pathway. 3,4-dihydroxyphenylethanol 18-32 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 93-97 34525916-5 2022 Data reported for hydroxytyrosol suggest that the activation of the hepatic PPAR-alpha-FGF21-AMPK-PGC-1alpha signaling cascade is associated with fatty acid oxidation enhancement, de novo lipogenesis diminution and recovery of mitochondrial function, a contention that is supported by the actions of several polyphenols on specific components of this signaling pathway. 3,4-dihydroxyphenylethanol 18-32 PPARG coactivator 1 alpha Homo sapiens 98-108 35077933-10 2022 Based on the ADMET and molecular docking data, the hERG inhibitory activities of verbascoside, oleuropein, and hydroxytyrosol were investigated using patch clamp assays and they were identified as non-inhibitors. 3,4-dihydroxyphenylethanol 111-125 ETS transcription factor ERG Homo sapiens 51-55 35229750-14 2022 In sum, in HepG2 hepatoma cells, hydroxytyrosol elicited (Ca2+)i raises by provoking PLC-unrelated discharge of Ca2+ from ER and Ca2+ influx through PKC-sensitive store-operated Ca2+ entry. 3,4-dihydroxyphenylethanol 33-47 carbonic anhydrase 2 Homo sapiens 58-61 35229750-0 2022 Hydroxytyrosol (2-(3,4-dihydroxyphenyl)-ethanol), a natural phenolic compound found in the olive, alters Ca2+ signaling and viability in human HepG2 hepatoma cells. 3,4-dihydroxyphenylethanol 16-47 carbonic anhydrase 2 Homo sapiens 105-108 35229750-5 2022 This study was aimed to delineate the action of hydroxytyrosol on viability and (Ca2+)i in HepG2 hepatoma cells. 3,4-dihydroxyphenylethanol 48-62 carbonic anhydrase 2 Homo sapiens 81-84 35229750-7 2022 Hydroxytyrosol elicited (Ca2+)i raises. 3,4-dihydroxyphenylethanol 0-14 carbonic anhydrase 2 Homo sapiens 25-28 35229750-9 2022 Hydroxytyrosol-evoked Ca2+ influx was diminished by 20% by three inhibitors of store-operated Ca2+ channels and by a protein kinase C activator and an inhibitor. 3,4-dihydroxyphenylethanol 0-14 carbonic anhydrase 2 Homo sapiens 22-25 35229750-9 2022 Hydroxytyrosol-evoked Ca2+ influx was diminished by 20% by three inhibitors of store-operated Ca2+ channels and by a protein kinase C activator and an inhibitor. 3,4-dihydroxyphenylethanol 0-14 carbonic anhydrase 2 Homo sapiens 94-97 35229750-10 2022 In the absence of Ca2+, thapsigargin eradicated hydroxytyrosol-provoked (Ca2+)i raises. 3,4-dihydroxyphenylethanol 48-62 carbonic anhydrase 2 Homo sapiens 73-76 35229750-14 2022 In sum, in HepG2 hepatoma cells, hydroxytyrosol elicited (Ca2+)i raises by provoking PLC-unrelated discharge of Ca2+ from ER and Ca2+ influx through PKC-sensitive store-operated Ca2+ entry. 3,4-dihydroxyphenylethanol 33-47 carbonic anhydrase 2 Homo sapiens 112-115 35229750-14 2022 In sum, in HepG2 hepatoma cells, hydroxytyrosol elicited (Ca2+)i raises by provoking PLC-unrelated discharge of Ca2+ from ER and Ca2+ influx through PKC-sensitive store-operated Ca2+ entry. 3,4-dihydroxyphenylethanol 33-47 carbonic anhydrase 2 Homo sapiens 129-132 35229750-14 2022 In sum, in HepG2 hepatoma cells, hydroxytyrosol elicited (Ca2+)i raises by provoking PLC-unrelated discharge of Ca2+ from ER and Ca2+ influx through PKC-sensitive store-operated Ca2+ entry. 3,4-dihydroxyphenylethanol 33-47 carbonic anhydrase 2 Homo sapiens 178-181 35229750-15 2022 In addition, hydroxytyrosol elicited Ca2+-dissociated cytotoxicity. 3,4-dihydroxyphenylethanol 13-27 carbonic anhydrase 2 Homo sapiens 37-40