PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29982934-3	2018	In this work, we prepared magnetic molecularly imprinted nanoparticles (deep eutectic solvent-molecular imprinting polymers [DES-MIPs]) with a deep eutectic solvent (DES) as a functional monomer to separate TrF in human serum.	desacetyluvaricin	125-128	transferrin	Homo sapiens	207-210
31212686-0	2019	The Versatile Applications of DES and Their Influence on Oxidoreductase-Mediated Transformations.	desacetyluvaricin	30-33	thioredoxin reductase 1	Homo sapiens	57-71
31212686-4	2019	Here we analyze oxidoreductase-mediated transformations that are performed in the presence of DES and compare them with the ones that avoided those solvents.	desacetyluvaricin	94-97	thioredoxin reductase 1	Homo sapiens	16-30
31459894-1	2019	A volatile organic solvent-free and choline chloride (ChCl)-based deep eutectic system (DES)-mediated sp3-CH functionalization of acetophenones 1 with benzyl alcohols 2 to the corresponding alpha, beta-saturated ketones 3 is accounted for.	desacetyluvaricin	88-91	Sp3 transcription factor	Homo sapiens	102-105
30623274-5	2019	Exogenously applied CH4 not only triggered tomato lateral rooting, but also increased activities of L-cysteine desulfhydrase (DES; a major synthetic enzyme of H2S) and induced endogenous H2S production, and contrasting responses were observed in the presence of hypotaurine (HT; a scavenger of H2S) or DL-propargylglycine (PAG; an inhibitor of DES) alone.	desacetyluvaricin	126-129	L-cysteine desulfhydrase	Solanum lycopersicum	100-124
28926708-7	2017	1,3:2,4-Diethylidene-d-sorbitol (DES), another DBS analogue incapable of pi-pi stacking but with very different polarity, gelated a large Hansen space (2deltad = 34.0 MPa1/2, deltap = 10.9 MPa1/2, and deltah = 10.8 MPa1/2; radius = 9.2 MPa1/2).	desacetyluvaricin	33-36	guanylate binding protein 4	Homo sapiens	167-173
29198267-7	2018	Here we demonstrate differential expression of RASD1 gene and candidate microRNAs (miRNAs) targeting chicken RASD1 transcripts in chicken oviducts in response to diesthylstilbestrol (DES, a synthetic non-steroidal estrogen) and the estrogen-mediated molting process.	desacetyluvaricin	183-186	ras related dexamethasone induced 1	Gallus gallus	47-52
29198267-7	2018	Here we demonstrate differential expression of RASD1 gene and candidate microRNAs (miRNAs) targeting chicken RASD1 transcripts in chicken oviducts in response to diesthylstilbestrol (DES, a synthetic non-steroidal estrogen) and the estrogen-mediated molting process.	desacetyluvaricin	183-186	ras related dexamethasone induced 1	Gallus gallus	109-114
29198267-8	2018	Result of the present study indicated that expression of RASD1 messenger RNA (mRNA) increased in the developing oviducts of chicks treated with DES, particularly in the glandular (GE) and luminal (LE) epithelia of the magnum and the shell gland.	desacetyluvaricin	144-147	ras related dexamethasone induced 1	Gallus gallus	57-62
29571487-4	2018	A binary DES named HC-6, which was composed of 1,6-hexanediol:choline chloride (molar ratio 7:1) was designed to produce the highest efficiency.	desacetyluvaricin	9-12	CYCS pseudogene 52	Homo sapiens	19-23
29558926-4	2018	The amino acids desmosine and isodesmosine (DES) are unique to elastin.	desacetyluvaricin	44-47	elastin	Homo sapiens	63-70
28960443-0	2018	Spin-lattice relaxation studies on deep eutectic solvent/Choliniumtetrachloroferrate mixtures: Suitability of DES-based systems towards magnetic resonance imaging studies.	desacetyluvaricin	110-113	spindlin 1	Homo sapiens	0-4
28926708-7	2017	1,3:2,4-Diethylidene-d-sorbitol (DES), another DBS analogue incapable of pi-pi stacking but with very different polarity, gelated a large Hansen space (2deltad = 34.0 MPa1/2, deltap = 10.9 MPa1/2, and deltah = 10.8 MPa1/2; radius = 9.2 MPa1/2).	desacetyluvaricin	33-36	guanylate binding protein 4	Homo sapiens	189-195
28926708-7	2017	1,3:2,4-Diethylidene-d-sorbitol (DES), another DBS analogue incapable of pi-pi stacking but with very different polarity, gelated a large Hansen space (2deltad = 34.0 MPa1/2, deltap = 10.9 MPa1/2, and deltah = 10.8 MPa1/2; radius = 9.2 MPa1/2).	desacetyluvaricin	33-36	guanylate binding protein 4	Homo sapiens	189-195
28926708-7	2017	1,3:2,4-Diethylidene-d-sorbitol (DES), another DBS analogue incapable of pi-pi stacking but with very different polarity, gelated a large Hansen space (2deltad = 34.0 MPa1/2, deltap = 10.9 MPa1/2, and deltah = 10.8 MPa1/2; radius = 9.2 MPa1/2).	desacetyluvaricin	33-36	guanylate binding protein 4	Homo sapiens	189-195
29055397-10	2017	Since the amino acids desmosine and isodesmosine (DES) are unique to crosslinked elastin fibers, systemic elastin degradation can be assessed with the plasma DES assay.	desacetyluvaricin	50-53	elastin	Homo sapiens	81-88
28144332-3	2016	Moreover, using two different DES mixtures, the diastereoselectivity of the process could be tuned, thereby leading to the formation, under different experimental conditions, to both the syn- and the anti-isomer with very high enantioselectivity.	desacetyluvaricin	30-33	synemin	Homo sapiens	187-190
28557957-8	2017	A gene combination score calculated from 4 genes of gp130, SH2D1B, TNFalpha, and CCL4 was significantly higher in the AMR than the CMR (P < 0.0001) and no rejection control groups (P < 0.01 vs DES control, P < 0.05 vs non-DES control).	desacetyluvaricin	199-202	interleukin 6 cytokine family signal transducer	Homo sapiens	52-57
28557957-8	2017	A gene combination score calculated from 4 genes of gp130, SH2D1B, TNFalpha, and CCL4 was significantly higher in the AMR than the CMR (P < 0.0001) and no rejection control groups (P < 0.01 vs DES control, P < 0.05 vs non-DES control).	desacetyluvaricin	199-202	SH2 domain containing 1B	Homo sapiens	59-65
28557957-8	2017	A gene combination score calculated from 4 genes of gp130, SH2D1B, TNFalpha, and CCL4 was significantly higher in the AMR than the CMR (P < 0.0001) and no rejection control groups (P < 0.01 vs DES control, P < 0.05 vs non-DES control).	desacetyluvaricin	199-202	tumor necrosis factor	Homo sapiens	67-75
28557957-8	2017	A gene combination score calculated from 4 genes of gp130, SH2D1B, TNFalpha, and CCL4 was significantly higher in the AMR than the CMR (P < 0.0001) and no rejection control groups (P < 0.01 vs DES control, P < 0.05 vs non-DES control).	desacetyluvaricin	199-202	C-C motif chemokine ligand 4	Homo sapiens	81-85
28557957-8	2017	A gene combination score calculated from 4 genes of gp130, SH2D1B, TNFalpha, and CCL4 was significantly higher in the AMR than the CMR (P < 0.0001) and no rejection control groups (P < 0.01 vs DES control, P < 0.05 vs non-DES control).	desacetyluvaricin	231-234	interleukin 6 cytokine family signal transducer	Homo sapiens	52-57
28557957-8	2017	A gene combination score calculated from 4 genes of gp130, SH2D1B, TNFalpha, and CCL4 was significantly higher in the AMR than the CMR (P < 0.0001) and no rejection control groups (P < 0.01 vs DES control, P < 0.05 vs non-DES control).	desacetyluvaricin	231-234	SH2 domain containing 1B	Homo sapiens	59-65
28557957-8	2017	A gene combination score calculated from 4 genes of gp130, SH2D1B, TNFalpha, and CCL4 was significantly higher in the AMR than the CMR (P < 0.0001) and no rejection control groups (P < 0.01 vs DES control, P < 0.05 vs non-DES control).	desacetyluvaricin	231-234	tumor necrosis factor	Homo sapiens	67-75
28557957-8	2017	A gene combination score calculated from 4 genes of gp130, SH2D1B, TNFalpha, and CCL4 was significantly higher in the AMR than the CMR (P < 0.0001) and no rejection control groups (P < 0.01 vs DES control, P < 0.05 vs non-DES control).	desacetyluvaricin	231-234	C-C motif chemokine ligand 4	Homo sapiens	81-85
21978460-8	2011	We then determined that DES (dietylstilbestrol, a synthetic nonsteroidal estrogen) increased A2M mRNA only in LE and GE of the oviduct of chicks.	desacetyluvaricin	24-27	alpha-2-macroglobulin	Gallus gallus	93-96
26643912-12	2016	In immature rats, DES treatment resulted in increased mRNA expression of both channels and elevated TRPV1 immunopositivity.	desacetyluvaricin	18-21	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	100-105
26643912-14	2016	DES up-regulated Trpa1, Trpv1 and Mif mRNA levels in endometrial cell cultures, but 17beta-oestradiol having ERalpha-selective potency increased only the expression of Trpv1.	desacetyluvaricin	0-3	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	17-22
26643912-14	2016	DES up-regulated Trpa1, Trpv1 and Mif mRNA levels in endometrial cell cultures, but 17beta-oestradiol having ERalpha-selective potency increased only the expression of Trpv1.	desacetyluvaricin	0-3	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-29
26643912-14	2016	DES up-regulated Trpa1, Trpv1 and Mif mRNA levels in endometrial cell cultures, but 17beta-oestradiol having ERalpha-selective potency increased only the expression of Trpv1.	desacetyluvaricin	0-3	macrophage migration inhibitory factor	Rattus norvegicus	34-37
26542245-11	2015	CONCLUSION: Herein, we describe the use of DES to uncover an activating MTOR missense alteration of gonadal mosaic origin that is likely to be the causative mutation in two brothers who present multiple neurological and developmental abnormalities.	desacetyluvaricin	43-46	mechanistic target of rapamycin kinase	Homo sapiens	72-76
25296820-2	2014	The DES systems studied here are [0.75CH3CONH2 + 0.25{f KSCN + (1 - f )NaSCN}] and [0.78CH3CONH2 + 0.22{f LiBr + (1 - f )LiNO3}] with f = 0, 0.2, 0.4, 0.6, 0.8, and 1.0. gamma of these DES systems shows near insensitivity to f, while rho shows a moderate dependence on f. Interestingly, eta exhibits a strong dependence on f. In the low-frequency Kerr spectra, obtained via the Fourier transform of the collected Kerr transients, a characteristic band at ~70 cm(-1) is clear in [0.78CH3CONH2 + 0.22{f LiBr + (1 - f )LiNO3}] DES especially at the larger f. The band is attributed to the intermolecular hydrogen bond of acetamide.	desacetyluvaricin	4-7	endothelin receptor type A	Homo sapiens	287-290
23722327-5	2013	Lysozyme activity was also affected in neat and pseudo-concentrated GCCl-DES, with an increasing recovery of activity upon aqueous dilution, and full restoration after DES removal through extensive dialysis.	desacetyluvaricin	73-76	lysozyme	Homo sapiens	0-8
23620786-11	2013	In rats, DES effects are mediated via Estrogen Receptor alpha (ESR1).	desacetyluvaricin	9-12	estrogen receptor 1	Rattus norvegicus	63-67
23267130-4	2013	AIM: Here we investigated the effect of DES knockdown on the sphingolipid profile and apoptosis in human head and neck squamous carcinoma cells after PDT with the silicon phthalocyanine Pc 4.	desacetyluvaricin	40-43	proprotein convertase subtilisin/kexin type 4	Homo sapiens	186-190
23060697-2	2012	MATERIALS AND METHODS: Using DES and cisplatin (DDP) to intervene the cell lines of hepatocarcinoma G2.2.15 (HepG2.2.15) and HepG2, by detecting the expression of HBxAg by immunofluorescence method, the cell cycle and apoptosis by flow cytometry method (FCM), and expression of NF-kappaB protein by ELISA.	desacetyluvaricin	29-32	nuclear factor kappa B subunit 1	Homo sapiens	278-287
16604286-6	2006	DES gap-cornered boxes and the pillars influenced the arrangement of F-actin, microtubules, and vinculin.	desacetyluvaricin	0-3	vinculin	Rattus norvegicus	96-104
20110833-3	2010	SUMMARY OF BACKGROUND DATA: Two DE stages (DES) of injury to the cervical spine have been described as follows: DES-1 and DES-2.	desacetyluvaricin	43-46	delta 4-desaturase, sphingolipid 1	Homo sapiens	112-117
20110833-3	2010	SUMMARY OF BACKGROUND DATA: Two DE stages (DES) of injury to the cervical spine have been described as follows: DES-1 and DES-2.	desacetyluvaricin	43-46	delta 4-desaturase, sphingolipid 2	Homo sapiens	122-127
21543327-8	2011	4-HPR was found to inhibit DES in a dose-dependent manner.	desacetyluvaricin	27-30	haptoglobin-related protein	Homo sapiens	2-5
22087162-0	2011	The effect of desacetyluvaricin on the expression of TLR4 and P53 protein in Hepg 2.2.15.	desacetyluvaricin	14-31	toll like receptor 4	Homo sapiens	53-57
22087162-0	2011	The effect of desacetyluvaricin on the expression of TLR4 and P53 protein in Hepg 2.2.15.	desacetyluvaricin	14-31	tumor protein p53	Homo sapiens	62-65
22087162-4	2011	OBJECTIVES: To investigate the effect of Des on the expression of Toll-like receptor 4 (TLR4) and P53 protein in HCC.	desacetyluvaricin	41-44	toll like receptor 4	Homo sapiens	66-86
22087162-4	2011	OBJECTIVES: To investigate the effect of Des on the expression of Toll-like receptor 4 (TLR4) and P53 protein in HCC.	desacetyluvaricin	41-44	toll like receptor 4	Homo sapiens	88-92
22087162-4	2011	OBJECTIVES: To investigate the effect of Des on the expression of Toll-like receptor 4 (TLR4) and P53 protein in HCC.	desacetyluvaricin	41-44	tumor protein p53	Homo sapiens	98-101
22087162-6	2011	HepG2.2.15 cells were divided into three groups: control group, treated with Des and DDP (cisplatin) which were examined by immunofluorescence flow cytometry for expression of TLR4 and P53.	desacetyluvaricin	77-80	toll like receptor 4	Homo sapiens	176-180
19827035-2	2009	In the present study, we investigated the role of 17beta-estradiol (E2), diethylstibestrol (DES), and bisphenol A (BPA) in the phosphorylation of substrate by PKCalpha using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.	desacetyluvaricin	92-95	protein kinase C alpha	Homo sapiens	159-167
19827035-7	2009	Our study suggests that E2, DES, and BPA can bind to the C2 domain of PKCalpha but have no effects on the phosphorylation reaction of substrates in the presence of DAG and PS.	desacetyluvaricin	28-31	protein kinase C alpha	Homo sapiens	70-78
19493424-3	2009	The effect of DES on steroidogenic factor-1 (SF-1), that has been reported to control transcription of insulin-like factor 3 (INSL3), was also investigated.	desacetyluvaricin	14-17	splicing factor 1	Rattus norvegicus	21-49
19493424-10	2009	CONCLUSIONS: DES can inhibit transabdominal testicular descent in a dose-dependent manner via down-regulating the expression of INSL3, which is induced by down-regulating the expression of SF-1.	desacetyluvaricin	13-16	insulin-like 3	Rattus norvegicus	128-133
19493424-10	2009	CONCLUSIONS: DES can inhibit transabdominal testicular descent in a dose-dependent manner via down-regulating the expression of INSL3, which is induced by down-regulating the expression of SF-1.	desacetyluvaricin	13-16	splicing factor 1	Rattus norvegicus	189-193
16846617-5	2006	On the other hand, simultaneous treatment of F344 rats with thalidomide for the last 15 days of the experiment attenuated the stimulatory effect of DES on PRL and VEGF secretion.	desacetyluvaricin	148-151	prolactin	Rattus norvegicus	155-158
16846617-5	2006	On the other hand, simultaneous treatment of F344 rats with thalidomide for the last 15 days of the experiment attenuated the stimulatory effect of DES on PRL and VEGF secretion.	desacetyluvaricin	148-151	vascular endothelial growth factor A	Rattus norvegicus	163-167
16846617-6	2006	It also diminished prolactin cell proliferation evaluated as the number of proliferating cell nuclear antigen (PCNA)-positive stained cell nuclei and increased the number of apoptotic bodies determined by the terminal deoxynucleotidyl-mediated dUTP nick-end labeling (TUNEL) method in sections of the DES-induced pituitary prolactinoma.	desacetyluvaricin	301-304	prolactin	Rattus norvegicus	19-28
18947628-8	2006	In febrile patients, the presence of DES was associated with a lower risk of VUR [22/51 (43%) vs 23/34 (68%), P=0.03] and dilating VUR [5/51 (10%) vs 11/34 (32%), P=0.01], but not bilateral VUR [8/51 (16%) vs 11/34 (32%), P=0.11].	desacetyluvaricin	37-40	VUR	Homo sapiens	77-80
18947628-8	2006	In febrile patients, the presence of DES was associated with a lower risk of VUR [22/51 (43%) vs 23/34 (68%), P=0.03] and dilating VUR [5/51 (10%) vs 11/34 (32%), P=0.01], but not bilateral VUR [8/51 (16%) vs 11/34 (32%), P=0.11].	desacetyluvaricin	37-40	VUR	Homo sapiens	131-134
18947628-8	2006	In febrile patients, the presence of DES was associated with a lower risk of VUR [22/51 (43%) vs 23/34 (68%), P=0.03] and dilating VUR [5/51 (10%) vs 11/34 (32%), P=0.01], but not bilateral VUR [8/51 (16%) vs 11/34 (32%), P=0.11].	desacetyluvaricin	37-40	VUR	Homo sapiens	131-134
18947628-10	2006	Among children with a history of UTI, DES is a negative predictor for VUR.	desacetyluvaricin	38-41	VUR	Homo sapiens	70-73
15855622-1	2005	This study investigated whether transient, neonatal (days 2-12) treatment of rats with the potent oestrogen, diethylstilboestrol (DES), altered the structure of the cauda epididymis/vas deferens in adulthood, and if the changes observed related to altered development of basal cells in early puberty.	desacetyluvaricin	130-133	arginine vasopressin	Rattus norvegicus	182-185
2347930-5	1990	The results showed that 61% of the variance for DES scores could be predicted by three subscales of the HSCL-90 (Phobic Anxiety, Anger-Hostility, Somatization) and the TAS and BVRT.	desacetyluvaricin	48-51	selenocysteine lyase	Homo sapiens	104-108
16215308-1	2005	OBJECTIVE: To compare the efficacy of diethylstilboestrol (DES) with bicalutamide in the treatment of hormone refractory prostate cancer in relation to its effect on prostate-specific antigen (PSA) and survival.	desacetyluvaricin	59-62	kallikrein related peptidase 3	Homo sapiens	166-197
12225339-11	2002	CONCLUSIONS: In HRPC, treatment with stilboestrol is associated with a greater PSA fall and an increase in median survival when compared to flutamide treatment.	desacetyluvaricin	37-49	kallikrein related peptidase 3	Homo sapiens	79-82
12067250-1	2002	In this study, human glutathione transferases (GSTs) of alpha class have been assayed with the ultimate carcinogenic (-)-anti- and (+)-syn-diol epoxides (DEs) derived from the nonplanar dibenzo[a,l]pyrene (DBPDE) and the (+)-anti-diol epoxide of the planar benzo[a]pyrene [(+)-anti-BPDE] in the presence of glutathione (GSH).	desacetyluvaricin	154-157	glutathione S-transferase alpha 1	Homo sapiens	47-51
11417866-4	2001	The range of efficiencies obtained for DES were 51.8% (beta-glucuronidase, incubation at 37 degrees C overnight) and 2.7% (methanolic HCl), respectively.	desacetyluvaricin	39-42	beta-glucuronidase	Bos taurus	55-73
11331657-4	2001	There were gene specific differences, the PS2 and TGFbeta3 genes were about equally sensitive to Zeranol, 17beta-oestradiol and DES whereas a down-regulation of MRG1/p35srj could be detected at fmol/l concentrations of Zeranol whereas 17beta-oestradiol was several orders of magnitude less potent.	desacetyluvaricin	128-131	taste 2 receptor member 64 pseudogene	Homo sapiens	42-45
11331657-4	2001	There were gene specific differences, the PS2 and TGFbeta3 genes were about equally sensitive to Zeranol, 17beta-oestradiol and DES whereas a down-regulation of MRG1/p35srj could be detected at fmol/l concentrations of Zeranol whereas 17beta-oestradiol was several orders of magnitude less potent.	desacetyluvaricin	128-131	transforming growth factor beta 3	Homo sapiens	50-58
11278561-8	2001	The DESP/desmosine (DES) and IDP/isodesmosine (IDE) ratios in aorta elastin were higher than in other tissues.	desacetyluvaricin	4-7	elastin	Rattus norvegicus	68-75
11788009-3	2000	To this end, we measured mRNA levels and immunoreactivity for the CB1 receptor in the anterior pituitary gland of rats implanted with silastic capsules containing diethylstilbestrod (DES), a synthetic estrogen, or empty capsules.	desacetyluvaricin	183-186	cannabinoid receptor 1	Rattus norvegicus	66-69
11026564-7	2000	DES induction of PR immunoexpression was evident after a single injection (on day 3) and at 18-35 days the intensity of immunoexpression was DES dose-dependent; rats treated neonatally with 0.1 microg DES showed no detectable PR immunoexpression at any age.	desacetyluvaricin	0-3	progesterone receptor	Rattus norvegicus	17-19
9855012-3	1998	Glutathione tranferases (GSTs) have been demonstrated to catalyze the detoxification of DEs.	desacetyluvaricin	88-91	glutathione S-transferase pi 1	Homo sapiens	25-29
9855012-10	1998	This study demonstrates that differences in the caalytic activity seen for purified GST towards individual mutagens do not necessarily reflect the detoxification of DEs by the same enzyme in a living cell and provides further evidence that specific human GSTs play a role in the detoxification of DEs of PAHs.	desacetyluvaricin	165-168	glutathione S-transferase pi 1	Homo sapiens	255-259
9855012-10	1998	This study demonstrates that differences in the caalytic activity seen for purified GST towards individual mutagens do not necessarily reflect the detoxification of DEs by the same enzyme in a living cell and provides further evidence that specific human GSTs play a role in the detoxification of DEs of PAHs.	desacetyluvaricin	297-300	glutathione S-transferase pi 1	Homo sapiens	255-259
11026564-7	2000	DES induction of PR immunoexpression was evident after a single injection (on day 3) and at 18-35 days the intensity of immunoexpression was DES dose-dependent; rats treated neonatally with 0.1 microg DES showed no detectable PR immunoexpression at any age.	desacetyluvaricin	0-3	progesterone receptor	Rattus norvegicus	226-228
11026564-11	2000	In DES-treated rats, immunoexpression of PR in the reproductive tract decreased progressively in intensity from days 18-35 and was non-detectable in adulthood.	desacetyluvaricin	3-6	progesterone receptor	Rattus norvegicus	41-43
10362780-9	1999	The SCH-sensitive net HCO-3 flux remained unchanged, whereas the DES-sensitive HCO-3 flux increased in the CCD of NHE-3 mutant animals.	desacetyluvaricin	65-68	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	114-119
10362780-13	1999	Both the SCH-sensitive and the DES-sensitive HCO-3 fluxes increased in the OMCD of NHE-3 mutant animals.	desacetyluvaricin	31-34	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	83-88
9239689-2	1996	In this study, the mechanisms of the in-vitro effects of human prolactin (hPRL) on human follicle stimulating hormone (hFSH)-induced aromatase activity were determined using cultured granulosa cells from diethylstilboestrol (DES)-primed immature rats.	desacetyluvaricin	225-228	prolactin	Homo sapiens	63-72
9239689-2	1996	In this study, the mechanisms of the in-vitro effects of human prolactin (hPRL) on human follicle stimulating hormone (hFSH)-induced aromatase activity were determined using cultured granulosa cells from diethylstilboestrol (DES)-primed immature rats.	desacetyluvaricin	225-228	prolactin	Homo sapiens	74-78
8656443-12	1996	Estrogen receptor-positive cells and estrogen receptor-negative cells were equally responsive to DES.	desacetyluvaricin	97-100	estrogen receptor 1	Homo sapiens	0-17
8656443-12	1996	Estrogen receptor-positive cells and estrogen receptor-negative cells were equally responsive to DES.	desacetyluvaricin	97-100	estrogen receptor 1	Homo sapiens	37-54
8656443-16	1996	CONCLUSIONS: Direct cytotoxic effects of DES in prostate cancer cells are estrogen receptor independent and do not involve disruption of microtubule architecture but do involve the promotion of cell cycle arrest and apoptosis.	desacetyluvaricin	41-44	estrogen receptor 1	Homo sapiens	74-91
1576426-4	1992	It has been shown that prolonged mesulergine treatment attenuated the stimulatory effect of stilboestrol on prolactin secretion in vivo.	desacetyluvaricin	92-104	prolactin	Rattus norvegicus	108-117
2141919-4	1990	Amantadine, given in the subcutaneous doses of 50, 5 and 0.5 mg/kg of body weight attenuated the stimulatory effect of stilboestrol on serum prolactin concentration in a dose-dependent fashion.	desacetyluvaricin	119-131	prolactin	Rattus norvegicus	141-150
3386256-1	1988	The relative rate of ovalbumin transcription was significantly increased (P less than 0.001) when purified chick liver glucocorticosteroid receptor (GR) was incubated with purified nuclei prepared from the oviducts of diethylstilboestrol (DES)-primed chickens 24 h after oestrogen withdrawal.	desacetyluvaricin	239-242	ovalbumin (SERPINB14)	Gallus gallus	21-30
35175257-3	2022	In this context, herein, we have investigated the effect of reline (a choline chloride : urea mixture in 1 : 2 proportion) DES in its pure and hydrated forms on the structural stability and conformation of the bovine serum albumin (BSA) protein using all-atom molecular dynamics simulations.	desacetyluvaricin	123-126	albumin	Homo sapiens	217-230
35094119-8	2022	Concerning the ER, the deep learning model on the DES images had an AUC of 0.83 with the image-by-image analysis and of 0.85 for the majority voting.	desacetyluvaricin	50-53	estrogen receptor 1	Homo sapiens	15-17
3625096-6	1987	Treatment with DES dramatically increased serum prolactin concentrations and prolactin mRNA and induced pituitary tumour formation as shown by histological changes.	desacetyluvaricin	15-18	prolactin	Rattus norvegicus	48-57
3625096-6	1987	Treatment with DES dramatically increased serum prolactin concentrations and prolactin mRNA and induced pituitary tumour formation as shown by histological changes.	desacetyluvaricin	15-18	prolactin	Rattus norvegicus	77-86
3625096-7	1987	Withdrawal of DES for 1 week did not lead to a decrease in pituitary tumour weight but was accompanied by a decrease in serum prolactin concentrations and prolactin mRNA from peak concentrations although they remained significantly increased above controls.	desacetyluvaricin	14-17	prolactin	Rattus norvegicus	126-135
3625096-7	1987	Withdrawal of DES for 1 week did not lead to a decrease in pituitary tumour weight but was accompanied by a decrease in serum prolactin concentrations and prolactin mRNA from peak concentrations although they remained significantly increased above controls.	desacetyluvaricin	14-17	prolactin	Rattus norvegicus	155-164
6609784-2	1984	DES over the dose range 10(-4)-2 X 10(-5) M inhibits cervical epithelial cell (HCE) growth in terms of colony formation and colony expansion.	desacetyluvaricin	0-3	RNA guanylyltransferase and 5'-phosphatase	Homo sapiens	79-82
3267288-4	1987	PBF was progressively reduced to 25% by DES in 13 weeks but the total adenohypophysial blood flow (flow as measured per unit weight multiplied by weight of the gland) was raised by 75%.	desacetyluvaricin	40-43	PTTG1 interacting protein	Rattus norvegicus	0-3
4026804-1	1985	Prenatal exposure of the female chick-embryo Mullerian duct to diethylstilboestrol (DES) decreases its future capacity for epithelial tubular-gland-cell differentiation and oviduct ovalbumin-gene expression.	desacetyluvaricin	84-87	ovalbumin (SERPINB14)	Gallus gallus	181-190
4026804-4	1985	Comparisons among these three parameters revealed that the expression of the ovalbumin gene was affected most by DES exposure.	desacetyluvaricin	113-116	ovalbumin (SERPINB14)	Gallus gallus	77-86
4026804-5	1985	Exposure to high doses of DES suppressed ovalbumin-gene expression by 75-78%, and inhibited tubular-gland-cell differentiation and thus decreased the DNA content by 29 and 32% respectively.	desacetyluvaricin	26-29	ovalbumin (SERPINB14)	Gallus gallus	41-50
4026804-6	1985	Exposure to low doses of DES caused suppression of ovalbumin-gene expression by 47-53%, but it did not affect the other two parameters.	desacetyluvaricin	25-28	ovalbumin (SERPINB14)	Gallus gallus	51-60
3782146-1	1986	The cytochrome P-450-mediated reactions of the synthetic stilbene estrogen (E)-diethylstilbestrol (DES) and of 2-hydroxyestradiol have been investigated in vitro.	desacetyluvaricin	75-97	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	4-20
3933710-3	1985	Stilboestrol increased supine plasma renin and angiotensin II values but the response of renin-angiotensin-aldosterone activity to erect posture was progressively reduced during treatment.	desacetyluvaricin	0-12	renin	Homo sapiens	37-42
6240150-7	1984	Patients previously treated with stilboestrol are unlikely to respond to orchidectomy or LHRH analogue.	desacetyluvaricin	33-45	gonadotropin releasing hormone 1	Homo sapiens	89-93
6418053-2	1983	In pregnant and stilboestrol-treated patients matched for TBG concentrations, serum FT4 concentrations measured by the Amerlex technique and by calculation, were reduced, as also was the total thyroxine (TT4)/TBG ratio.	desacetyluvaricin	16-28	serpin family A member 7	Homo sapiens	58-61
6418053-2	1983	In pregnant and stilboestrol-treated patients matched for TBG concentrations, serum FT4 concentrations measured by the Amerlex technique and by calculation, were reduced, as also was the total thyroxine (TT4)/TBG ratio.	desacetyluvaricin	16-28	serpin family A member 7	Homo sapiens	209-212
788774-6	1976	Bromocriptine effectively reduced serum prolactin and prevented lactation; stilboestrol increased serum prolactin and partially suppressed lactation; clomiphene citrate and testosterone propionate both lowered serum prolactin levels and partially suppressed lactation.	desacetyluvaricin	75-87	prolactin	Homo sapiens	104-113
6651924-7	1983	Macrophages isolated from the stilboestrol model show levels of NAG production similar to normal (0.34 +/- 0.06 units), but this increases significantly following exposure to endotoxin (0.42 +/- 0.07 units).	desacetyluvaricin	30-42	O-GlcNAcase	Rattus norvegicus	64-67
313661-2	1979	In relatively low concentrations (5 muM), DES greatly potentiates the twitch response of the fibre without significantly affecting the amplitude of the tetanus response.	desacetyluvaricin	42-45	latexin	Homo sapiens	36-39
6630336-1	1983	A rapid method for the selective detection and quantitation of diethylstilboestrol (DES) residues at the 1 ppb level in extracts of urine and animal tissues is described.	desacetyluvaricin	84-87	histatin 1	Homo sapiens	107-110
788774-6	1976	Bromocriptine effectively reduced serum prolactin and prevented lactation; stilboestrol increased serum prolactin and partially suppressed lactation; clomiphene citrate and testosterone propionate both lowered serum prolactin levels and partially suppressed lactation.	desacetyluvaricin	75-87	prolactin	Homo sapiens	104-113
1260172-8	1976	6 Stilboestrol, an oestrogen, caused a significant increase of uterine renin-like activity.	desacetyluvaricin	2-14	renin	Rattus norvegicus	71-76
946155-5	1976	Changes in growth hormone concentrations were more varied in response to stilboestrol, being elevated in several patients and remaining unchanged in others.	desacetyluvaricin	73-85	growth hormone 1	Homo sapiens	11-25
4726322-0	1973	Early effects of stilboestrol on growth hormone and prolactin secretion and on pituitary mitotic activity in the male rat.	desacetyluvaricin	17-29	prolactin	Rattus norvegicus	52-61
33039858-1	2021	Herein, self-supported Ni3S2 spherical clusters packed with well-defined nanosheets developed on Ni foam (NF) were rationally fabricated via a novel low-temperature solvothermal sulfurization approach in a choline chloride/ethylene glycol (Ethaline)-based deep eutectic solvent (DES).	desacetyluvaricin	279-282	neurofascin	Homo sapiens	106-108
14777862-0	1950	Specific and non-specific serum cholinesterase in cats before and after treatment with stilboestrol.	desacetyluvaricin	87-99	butyrylcholinesterase	Felis catus	32-46
5122827-0	1971	Effects of stilboestrol on growth hormone secretion and pituitary cell proliferation in the male rat.	desacetyluvaricin	11-23	gonadotropin releasing hormone receptor	Rattus norvegicus	27-41
21013371-0	1946	Capon production by the use of synthetic oestrogen (stilboestrol).	desacetyluvaricin	52-64	nitric oxide synthase 1 adaptor protein	Homo sapiens	0-5
34035939-2	2021	Five different phenolics-based DESs were successfully synthesized by using phenol (DES 1), 2-chlorophenol (DES 2), 3-chlorophenol (DES 3), 4-chlorophenol (DES 4) and 3,4-dichlorophenol (DES 6) as the hydrogen-bond donor (HBD) and choline chloride as the hydrogen-bond acceptor (HBA).	desacetyluvaricin	31-34	delta 4-desaturase, sphingolipid 1	Homo sapiens	83-88
34035939-2	2021	Five different phenolics-based DESs were successfully synthesized by using phenol (DES 1), 2-chlorophenol (DES 2), 3-chlorophenol (DES 3), 4-chlorophenol (DES 4) and 3,4-dichlorophenol (DES 6) as the hydrogen-bond donor (HBD) and choline chloride as the hydrogen-bond acceptor (HBA).	desacetyluvaricin	31-34	delta 4-desaturase, sphingolipid 2	Homo sapiens	107-112
34035939-2	2021	Five different phenolics-based DESs were successfully synthesized by using phenol (DES 1), 2-chlorophenol (DES 2), 3-chlorophenol (DES 3), 4-chlorophenol (DES 4) and 3,4-dichlorophenol (DES 6) as the hydrogen-bond donor (HBD) and choline chloride as the hydrogen-bond acceptor (HBA).	desacetyluvaricin	31-34	fatty acid desaturase 2	Homo sapiens	186-191
33507168-4	2021	The solvation free energy of ethyl violet (EV) in DES (-17.128 to -21.681 kcal mol-1) is much larger than that in water (-0.411 kcal mol-1), and increases with the increase of the HBD chain length, which is proportional to the extraction rate, indicating that the TPM molecules are more inclined to the DES environment, especially long-chain DES, than aqueous solution.	desacetyluvaricin	50-53	HBD	Homo sapiens	180-183
33668455-0	2021	Development of Novel Polyamide-Imide/DES Composites and Their Application for Pervaporation and Gas Separation.	desacetyluvaricin	37-40	gastrin	Homo sapiens	96-99
33067638-20	2020	DES-induced CD11b, LOX-1, PD-L2 expression and STAT5 phosphorylation in neutrophils.	desacetyluvaricin	0-3	integrin subunit alpha M	Homo sapiens	12-17
33067638-20	2020	DES-induced CD11b, LOX-1, PD-L2 expression and STAT5 phosphorylation in neutrophils.	desacetyluvaricin	0-3	oxidized low density lipoprotein receptor 1	Homo sapiens	19-24
33067638-20	2020	DES-induced CD11b, LOX-1, PD-L2 expression and STAT5 phosphorylation in neutrophils.	desacetyluvaricin	0-3	programmed cell death 1 ligand 2	Homo sapiens	26-31
33067638-20	2020	DES-induced CD11b, LOX-1, PD-L2 expression and STAT5 phosphorylation in neutrophils.	desacetyluvaricin	0-3	signal transducer and activator of transcription 5A	Homo sapiens	47-52
33067638-24	2020	DES significantly induced CD11b, LOX-1, PD-L2 expression and STAT5 phosphorylation.	desacetyluvaricin	0-3	integrin subunit alpha M	Homo sapiens	26-31
33067638-24	2020	DES significantly induced CD11b, LOX-1, PD-L2 expression and STAT5 phosphorylation.	desacetyluvaricin	0-3	oxidized low density lipoprotein receptor 1	Homo sapiens	33-38
33067638-24	2020	DES significantly induced CD11b, LOX-1, PD-L2 expression and STAT5 phosphorylation.	desacetyluvaricin	0-3	programmed cell death 1 ligand 2	Homo sapiens	40-45
33067638-24	2020	DES significantly induced CD11b, LOX-1, PD-L2 expression and STAT5 phosphorylation.	desacetyluvaricin	0-3	signal transducer and activator of transcription 5A	Homo sapiens	61-66