PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 22669917-3 2012 We characterized ASBT orthologs from two primitive vertebrates, the lamprey that utilizes early 5alpha-bile alcohols and the skate that utilizes structurally different 5beta-bile alcohols, and compared substrate specificity with ASBT from humans who utilize modern 5beta-bile acids. 5alpha-bile alcohols 96-116 solute carrier family 10 member 2 Homo sapiens 17-21 22669917-6 2012 Cell-based assays using recombinant ASBT/Asbt"s indicate that lamprey Asbt has high affinity for 5alpha-bile alcohols, low affinity for 5beta-bile alcohols, and lacks affinity for TCA, whereas skate Asbt showed high affinity for 5alpha- and 5beta-bile alcohols but low affinity for TCA. 5alpha-bile alcohols 97-117 solute carrier family 10 member 2 Homo sapiens 70-74 22669917-6 2012 Cell-based assays using recombinant ASBT/Asbt"s indicate that lamprey Asbt has high affinity for 5alpha-bile alcohols, low affinity for 5beta-bile alcohols, and lacks affinity for TCA, whereas skate Asbt showed high affinity for 5alpha- and 5beta-bile alcohols but low affinity for TCA. 5alpha-bile alcohols 97-117 solute carrier family 10 member 2 Homo sapiens 70-74 16300737-0 2006 5Alpha-bile alcohols function as farnesoid X receptor antagonists. 5alpha-bile alcohols 0-20 xenotropic and polytropic retrovirus receptor 1 Homo sapiens 43-53