PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 22538270-8 2012 In human hepatocytes and/or liver microsomes, gemfibrozil potently inhibited the hydroxylation of BRV-AC into BRV-OHAC (K(I) 12 muM) while having a marginal effect on BRV-OH formation (K(I) >=153 muM). brv-ac 98-104 latexin Homo sapiens 128-131 22538270-8 2012 In human hepatocytes and/or liver microsomes, gemfibrozil potently inhibited the hydroxylation of BRV-AC into BRV-OHAC (K(I) 12 muM) while having a marginal effect on BRV-OH formation (K(I) >=153 muM). brv-ac 98-104 latexin Homo sapiens 199-202 22538270-11 2012 Overall, in vitro and in vivo data suggest that CYP2C8 and CYP2C9 are not involved in BRV hydroxylation, whereas hydroxylation of BRV-AC to BRV-OHAC is likely to be mediated by CYP2C9. brv-ac 130-136 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 177-183