PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 18322448-6 2008 However, intestinal CYP3A4 expression was shown to correlate directly with partial metabolic clearances of 16-hydroxy-prednisolone (r(2) = 0.30; P = 0.010) and 6-hydroxy-budesonide (r(2) = 0.25; P = 0.016), but inversely with budesonide AUC(0-24 h) (r(2) = 0.18; P = 0.040). 6-hydroxybudesonide 160-180 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 20-26 7720517-8 1995 In addition, formation of the budesonide metabolites (16 alpha-hydroxyprednisolone and 6 beta-hydroxybudesonide) was inhibited by antibodies against the CYP3A subfamily, but not by antibodies against the CYP1A subfamily or control immunoglobulin G. We conclude that the formation of 16 alpha-hydroxyprednisolone and 6 beta-hydroxybudesonide from budesonide is catalyzed by isoenzymes within the CYP3A subfamily. 6-hydroxybudesonide 87-111 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 153-158 7720517-8 1995 In addition, formation of the budesonide metabolites (16 alpha-hydroxyprednisolone and 6 beta-hydroxybudesonide) was inhibited by antibodies against the CYP3A subfamily, but not by antibodies against the CYP1A subfamily or control immunoglobulin G. We conclude that the formation of 16 alpha-hydroxyprednisolone and 6 beta-hydroxybudesonide from budesonide is catalyzed by isoenzymes within the CYP3A subfamily. 6-hydroxybudesonide 87-111 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 395-400