PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34854215-8	2022	Moreover, overexpression of SNHG1 enhanced the adipogenic capacity of BMSCs but inhibited their osteogenic capacity as determined by oil red O, alizarin red, and alkaline phosphatase staining, while silencing of SNHG1 led to the opposite results.	alizarin	144-156	small nucleolar RNA host gene 1	Mus musculus	28-33
18965329-4	1991	The presence of complexing agents such as Alizarin Red (ARS), which forms a Ge(IV) complex adsorbed at the electrode, improved the sensitivity by one order of magnitude.	alizarin	42-54	RIEG2	Homo sapiens	56-59
34115259-3	2022	METHODS: miR-133a expression in radial artery samples was detected by FISH and Alizarin Red Staining.	alizarin	79-91	microRNA 133a-1	Rattus norvegicus	9-17
33811898-5	2021	Notably, hypoxia and TNF-alpha exerted accumulative effect in suppressing the osteogenic differentiation of DPSCs, as evidenced by reduced expression levels of osteogenesis-associated genes including ALP, RUNX2 and OCN in osteogenic condition, as well as reduced mineral nodules formation as indicated by alizarin red staining.	alizarin	305-317	tumor necrosis factor	Homo sapiens	21-30
16052480-12	2005	When osteoblastic cells with subconfluency were cultured in the presence of regucalcin (10(-10) or 10(-9) M) for 3, 9, or 18 days, the results with Alizarin red staining showed that the mineralization was markedly suppressed by culture with regucalcin for 3, 9, or 18 days.	alizarin	148-160	regucalcin	Mus musculus	76-86
34773642-6	2022	A potential osteogenic effect of neuropeptide Y and substance P was also investigated by measuring alkaline phosphatase (ALP) activity, Alizarin red staining and quantifying osteogenic gene expression.	alizarin	136-148	tachykinin precursor 1	Homo sapiens	52-63
34823575-6	2021	RT-PCR, western blot, immunofluorescence, alkaline phosphatase, and alizarin red staining were performed to assess the expression of PINK1 and osteogenic markers in silencing of PINK1 MC3T3-E1 cells.	alizarin	68-80	PTEN induced putative kinase 1	Mus musculus	178-183
34937023-10	2021	Lastly, hMSCs cultured on crosslinked (HEP/PLL) multilayers in the presence of soluble IFN- gamma successfully differentiated towards the osteogenic and adipogenic lineages as confirmed by Alizarin red, and oil-red O staining, as well as alkaline phosphatase activity.	alizarin	189-201	interferon gamma	Homo sapiens	87-97
34783818-1	2021	A range of titanium compounds containing the naturally occurring dyes quinizarin (QH2) and alizarin (AH2) was synthesized and structurally characterized in the solid state.	alizarin	91-99	zinc finger RANBP2-type containing 3	Homo sapiens	101-104
34328037-6	2021	Following subcutaneous implantation, GAL-coated scaffolds were associated with mineralized bone-like tissue deposits, which reacted positively for alizarin red and von Kossa, and demonstrated increased expression and protein levels of RUNX2, OCN, OSX, and iBSP.	alizarin	147-159	galanin and GMAP prepropeptide	Mus musculus	37-40
34821731-4	2021	The percentage of Alizarin red-stained area in the IL4-MSC and IL4-pMSC groups was significantly lower than in the MSC group.	alizarin	18-30	interleukin 4	Homo sapiens	51-54
34821731-4	2021	The percentage of Alizarin red-stained area in the IL4-MSC and IL4-pMSC groups was significantly lower than in the MSC group.	alizarin	18-30	interleukin 4	Homo sapiens	63-66
34821731-6	2021	The percentage of Alizarin red-stained area in the IL4-PDGF-BB-pMSC was significantly higher than in the IL4-PDGF-BB-MSC group.	alizarin	18-30	interleukin 4	Homo sapiens	51-54
34755671-9	2021	Alizarin red staining and ALP staining of the induced cells showed that the changes in the mineralization nodules were consistent with those of ALP activity.	alizarin	0-12	PDZ and LIM domain 3	Rattus norvegicus	144-147
34783865-5	2022	Two structural analogs of this compound were selective but less potent for inhibition of NAT1 whereas a third structural analog 1,2-dihydroxyanthraquinone (a compound 10 hydrolysis product also known as Alizarin) showed comparable potency and efficacy for human NAT1 inhibition.	alizarin	128-154	N-acetyltransferase 1	Homo sapiens	262-266
34783865-5	2022	Two structural analogs of this compound were selective but less potent for inhibition of NAT1 whereas a third structural analog 1,2-dihydroxyanthraquinone (a compound 10 hydrolysis product also known as Alizarin) showed comparable potency and efficacy for human NAT1 inhibition.	alizarin	203-211	N-acetyltransferase 1	Homo sapiens	89-93
34783865-5	2022	Two structural analogs of this compound were selective but less potent for inhibition of NAT1 whereas a third structural analog 1,2-dihydroxyanthraquinone (a compound 10 hydrolysis product also known as Alizarin) showed comparable potency and efficacy for human NAT1 inhibition.	alizarin	203-211	N-acetyltransferase 1	Homo sapiens	262-266
34783865-7	2022	Compound 10 and Alizarin effectively inhibited NAT1 in cryopreserved human hepatocytes whereas inhibition of NAT2 was not observed.	alizarin	16-24	N-acetyltransferase 1	Homo sapiens	47-51
34783865-11	2022	Alizarin"s ability to inhibit NAT1 could reduce breast cancer metastasis particularly to bone.	alizarin	0-8	N-acetyltransferase 1	Homo sapiens	30-34
34294355-9	2021	The Alizarin red-positive area was significantly higher on PCL/CS-PRF scaffold compared to PCL/CS scaffold, indicating more calcium deposition and osteogenic differentiation of HMSCs in the presence of PRF.	alizarin	4-16	citrate synthase	Homo sapiens	63-65
34591063-5	2021	Overexpression of periostin enhanced alkaline phosphatase (ALP) and alizarin red staining in OVX-BMSCs as well as the osteogenic genes OCN, BSP and Runx2.	alizarin	68-80	periostin	Rattus norvegicus	18-27
34526113-9	2021	RESULTS: Thrombin-activated PRP significantly enhanced cell viability, ALP activity, osteogenic-related mRNA levels and alizarin red-mineralization activity in hPDLSCs in a dose-dependent manner.	alizarin	120-132	coagulation factor II, thrombin	Homo sapiens	9-17
34342310-1	2021	Herein, we designed a diversified sensing platform for d-penicillamine based on amino-functionalized Zr-based metal-organic frameworks (UiO-66-NH2 MOFs) and 3-aminophenylboronic acid (APBA)@Alizarin Red (ARS).	alizarin	190-202	RIEG2	Homo sapiens	204-207
34342310-2	2021	The boronic acid group of 3-aminophenylboronic acid could react with Alizarin Red to form an APBA@ARS complex with a yellow fluorescence emission at 580 nm and ultraviolet absorption at 435 nm.	alizarin	69-81	RIEG2	Homo sapiens	98-101
34342310-4	2021	When copper ions were present in the reaction system of APBA and Alizarin Red, the copper ions could complex with Alizarin Red to prevent the generation of APBA@ARS, and the absorption of Cu@ARS at 530 nm occurred.	alizarin	65-77	RIEG2	Homo sapiens	161-164
34342310-4	2021	When copper ions were present in the reaction system of APBA and Alizarin Red, the copper ions could complex with Alizarin Red to prevent the generation of APBA@ARS, and the absorption of Cu@ARS at 530 nm occurred.	alizarin	65-77	RIEG2	Homo sapiens	191-194
34342310-4	2021	When copper ions were present in the reaction system of APBA and Alizarin Red, the copper ions could complex with Alizarin Red to prevent the generation of APBA@ARS, and the absorption of Cu@ARS at 530 nm occurred.	alizarin	114-126	RIEG2	Homo sapiens	161-164
34342310-4	2021	When copper ions were present in the reaction system of APBA and Alizarin Red, the copper ions could complex with Alizarin Red to prevent the generation of APBA@ARS, and the absorption of Cu@ARS at 530 nm occurred.	alizarin	114-126	RIEG2	Homo sapiens	191-194
34342310-6	2021	Nevertheless, when d-penicillamine and copper ions coexist in the APBA and Alizarin Red reaction system, the copper ions would complex with the sulfhydryl group of d-penicillamine and no longer hinder the generation of APBA@ARS, and the fluorescence of UiO-66-NH2 MOFs is quenched again.	alizarin	75-87	RIEG2	Homo sapiens	224-227
34126160-8	2021	The application of TRPA1 or TRPV1 agonists increased the mineralized nodules of alizarin red staining and alkaline phosphatase activity and upregulated the mRNA and protein expression of DSPP and OPN, respectively, with the highest values reached on the 7th day (P < 0.05).	alizarin	80-92	transient receptor potential cation channel subfamily A member 1	Homo sapiens	19-24
34126160-8	2021	The application of TRPA1 or TRPV1 agonists increased the mineralized nodules of alizarin red staining and alkaline phosphatase activity and upregulated the mRNA and protein expression of DSPP and OPN, respectively, with the highest values reached on the 7th day (P < 0.05).	alizarin	80-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-33
34350461-5	2021	The optimal concentrations of PTH and LPS were determined using alkaline phosphatase (ALP) activity assay, ALP staining, and Alizarin red staining.	alizarin	125-137	parathyroid hormone	Homo sapiens	30-33
34504437-14	2021	Alizarin red staining distinctly showed that pharmacological activation of Piezo1 channels by Yoda1 significantly suppressed mineralization, and shRNA-mediated knockdown of Piezo1 also significantly enhanced mineralization.	alizarin	0-12	piezo type mechanosensitive ion channel component 1	Homo sapiens	75-81
34456284-8	2021	qRT-PCR and alizarin red staining assays showed that MALAT1 silencing or miR-96 overexpression inhibits hBMSC osteogenic differentiation and vice versa.	alizarin	12-24	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	53-59
34456284-8	2021	qRT-PCR and alizarin red staining assays showed that MALAT1 silencing or miR-96 overexpression inhibits hBMSC osteogenic differentiation and vice versa.	alizarin	12-24	microRNA 96	Homo sapiens	73-79
34504437-14	2021	Alizarin red staining distinctly showed that pharmacological activation of Piezo1 channels by Yoda1 significantly suppressed mineralization, and shRNA-mediated knockdown of Piezo1 also significantly enhanced mineralization.	alizarin	0-12	piezo type mechanosensitive ion channel component 1	Homo sapiens	173-179
34194569-8	2021	In addition, BMSCs were treated with IGF-1 in osteogenic differentiation medium for 7 and 21 days, and alkaline phosphatase staining and Alizarin Red staining demonstrated significantly reduced osteogenic differentiation ability in the siRNA-Wnt3a group compared with the control group.	alizarin	137-149	Wnt family member 3A	Homo sapiens	242-247
34445461-6	2021	Moreover, the combination of THDC and AZ increased expression of genes associated with phospholipid homeostasis and keratinocyte differentiation, along with repression of MMP1 and MMP7 expression, inhibition of MMP enzyme activity, and increased production of collagen proteins by dermal fibroblasts.	alizarin	38-40	matrix metallopeptidase 1	Homo sapiens	171-175
34445461-6	2021	Moreover, the combination of THDC and AZ increased expression of genes associated with phospholipid homeostasis and keratinocyte differentiation, along with repression of MMP1 and MMP7 expression, inhibition of MMP enzyme activity, and increased production of collagen proteins by dermal fibroblasts.	alizarin	38-40	matrix metallopeptidase 7	Homo sapiens	180-184
34297624-4	2021	We then demonstrated that let-7f-5p impaired osteogenic differentiation of BM-MSCs in the absence and presence of TNF-alpha, as evidenced by alkaline phosphatase and alizarin red staining as well as quantitative assays of the mRNA levels of bone formation marker genes in differentiated BM-MSCs.	alizarin	166-178	tumor necrosis factor	Mus musculus	114-123
34277898-12	2021	After culturing on the material 14 days, the alizarin red staining showed that more calcium deposition was detected in group A and alkaline phosphatase activities of group A was higher than group B (p   0.05).	alizarin	45-57	alkaline phosphatase, placental	Homo sapiens	131-151
34693426-4	2021	Meanwhile, the effect of DKK1 on differentiation of human dental cells exposed to LPS were studied by alizarin red staining and real-time PCR experiment, statistical analysis was performed using SPSS 20.0 software package.	alizarin	102-114	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	25-29
34693426-7	2021	The results of Alizarin red staining and real-time PCR revealed that DKK1 could promote cytodifferentiation of dental pulp cells exposed to LPS.	alizarin	15-27	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	69-73
34308601-4	2021	ALP staining, alizarin red staining, osteocalcin (OCN) immunofluorescence staining, and Western blot were used to explore the effect of scaffolds on osteogenic differentiation of BMSCs, and the optimal concentration of TGF-beta 1/GelMA scaffold was selected.	alizarin	14-26	transforming growth factor, beta 1	Rattus norvegicus	219-229
35549815-4	2022	The functions of miR-21-5p in osteoporosis were assessed by cell counting kit-8 (CCK-8) assay, alkaline phosphatase (ALP) staining and alizarin red staining assays.	alizarin	135-147	microRNA 215	Homo sapiens	17-26
34093426-13	2021	Compared with calcification medium, Alizarin Red staining showed calcium disposition was more obvious, and the mRNA level of BMP2, Runx2 and OCN was significantly increased, and immunofluorescence and Western blot analysis showed that the expression of alpha-SMA was downregulated in VSMCs treated by leptin (400 ng/ml) combined with calcification medium, respectively.	alizarin	36-48	bone morphogenetic protein 2	Homo sapiens	125-129
34093426-13	2021	Compared with calcification medium, Alizarin Red staining showed calcium disposition was more obvious, and the mRNA level of BMP2, Runx2 and OCN was significantly increased, and immunofluorescence and Western blot analysis showed that the expression of alpha-SMA was downregulated in VSMCs treated by leptin (400 ng/ml) combined with calcification medium, respectively.	alizarin	36-48	RUNX family transcription factor 2	Homo sapiens	131-136
34093426-13	2021	Compared with calcification medium, Alizarin Red staining showed calcium disposition was more obvious, and the mRNA level of BMP2, Runx2 and OCN was significantly increased, and immunofluorescence and Western blot analysis showed that the expression of alpha-SMA was downregulated in VSMCs treated by leptin (400 ng/ml) combined with calcification medium, respectively.	alizarin	36-48	bone gamma-carboxyglutamate protein	Homo sapiens	141-144
34093426-13	2021	Compared with calcification medium, Alizarin Red staining showed calcium disposition was more obvious, and the mRNA level of BMP2, Runx2 and OCN was significantly increased, and immunofluorescence and Western blot analysis showed that the expression of alpha-SMA was downregulated in VSMCs treated by leptin (400 ng/ml) combined with calcification medium, respectively.	alizarin	36-48	actin alpha 1, skeletal muscle	Homo sapiens	253-262
34093426-13	2021	Compared with calcification medium, Alizarin Red staining showed calcium disposition was more obvious, and the mRNA level of BMP2, Runx2 and OCN was significantly increased, and immunofluorescence and Western blot analysis showed that the expression of alpha-SMA was downregulated in VSMCs treated by leptin (400 ng/ml) combined with calcification medium, respectively.	alizarin	36-48	leptin	Homo sapiens	301-307
35341776-8	2022	KCNQ1OT1 promoted RICTOR expression via inhibiting miR-205-5p, therefore promoting osteogenesis as demonstrated by ALP assay, alizarin red staining and the increased expression of osteogenic markers (OPN, RUNX2 and OCN).	alizarin	126-138	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	0-8
35601075-10	2022	ALP and the mineralization capacity of hPDLSCs were detected by ALP activity assay and Alizarin red staining.	alizarin	87-99	alkaline phosphatase, placental	Homo sapiens	0-3
35594585-5	2022	Moreover, increased expression of MMP2 could contribute to forming more calcium nodules representative for osteoblast calcification verified by the alizarin red staining, vice versa.	alizarin	148-160	matrix metallopeptidase 2	Homo sapiens	34-38
35543755-4	2022	Our results showed that knockdown of PRMT6 promoted the osteo/odontogenic differentiation compared with the control group, as detected by alkaline phosphatase activity, alizarin red staining, and the indicators of osteo/odontogenic differentiation measured by Western blot.	alizarin	169-181	protein arginine methyltransferase 6	Homo sapiens	37-42
35149088-5	2022	Alizarin red staining and calcium content assays showed that BRCC36 overexpression reduced calcium deposition in the presence of calcifying medium, while the contractile protein alpha-smooth muscle actin (alpha-SMA) was upregulated and phosphorylated beta-catenin was downregulated.	alizarin	0-12	BRCA1/BRCA2-containing complex subunit 3	Homo sapiens	61-67
35541911-0	2022	Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-kappaB activation.	alizarin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	90-99
35541911-1	2022	The current performance of nature compounds in antitumor field is gradually attracted more and more attention, we discovered a nature active ingredient alizarin possess potent natural reductive NF-kappaB activity to against pancreatic cancer.	alizarin	152-160	nuclear factor kappa B subunit 1	Homo sapiens	194-203
35541911-4	2022	Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-alpha-stimulated NF-kappaB activity and nuclear translocation, and inactivated its related TNF-alpha-TAK1-NF-kappaB signaling cascade followed by downregulation of NF-kappaB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc).	alizarin	0-8	tumor necrosis factor	Homo sapiens	77-86
35541911-4	2022	Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-alpha-stimulated NF-kappaB activity and nuclear translocation, and inactivated its related TNF-alpha-TAK1-NF-kappaB signaling cascade followed by downregulation of NF-kappaB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc).	alizarin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	98-107
35541911-4	2022	Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-alpha-stimulated NF-kappaB activity and nuclear translocation, and inactivated its related TNF-alpha-TAK1-NF-kappaB signaling cascade followed by downregulation of NF-kappaB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc).	alizarin	0-8	tumor necrosis factor	Homo sapiens	172-181
35541911-4	2022	Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-alpha-stimulated NF-kappaB activity and nuclear translocation, and inactivated its related TNF-alpha-TAK1-NF-kappaB signaling cascade followed by downregulation of NF-kappaB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc).	alizarin	0-8	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	182-186
35541911-4	2022	Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-alpha-stimulated NF-kappaB activity and nuclear translocation, and inactivated its related TNF-alpha-TAK1-NF-kappaB signaling cascade followed by downregulation of NF-kappaB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc).	alizarin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	187-196
35541911-4	2022	Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-alpha-stimulated NF-kappaB activity and nuclear translocation, and inactivated its related TNF-alpha-TAK1-NF-kappaB signaling cascade followed by downregulation of NF-kappaB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc).	alizarin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	245-254
35541911-4	2022	Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-alpha-stimulated NF-kappaB activity and nuclear translocation, and inactivated its related TNF-alpha-TAK1-NF-kappaB signaling cascade followed by downregulation of NF-kappaB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc).	alizarin	0-8	BCL2 apoptosis regulator	Homo sapiens	296-301
35541911-4	2022	Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-alpha-stimulated NF-kappaB activity and nuclear translocation, and inactivated its related TNF-alpha-TAK1-NF-kappaB signaling cascade followed by downregulation of NF-kappaB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc).	alizarin	0-8	BCL2 like 1	Homo sapiens	303-309
35541911-4	2022	Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-alpha-stimulated NF-kappaB activity and nuclear translocation, and inactivated its related TNF-alpha-TAK1-NF-kappaB signaling cascade followed by downregulation of NF-kappaB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc).	alizarin	0-8	X-linked inhibitor of apoptosis	Homo sapiens	311-315
35541911-4	2022	Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-alpha-stimulated NF-kappaB activity and nuclear translocation, and inactivated its related TNF-alpha-TAK1-NF-kappaB signaling cascade followed by downregulation of NF-kappaB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc).	alizarin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	361-366
35541911-5	2022	Due to the abrogation of NF-kappaB activity, combination of alizarin and gemcitabine exerted a better inhibitory effect on pancreatic cancer.	alizarin	60-68	nuclear factor kappa B subunit 1	Homo sapiens	25-34
35541911-6	2022	In summary, natural component alizarin, inhibited cell proliferation and induced apoptosis in vitro and in vivo through targeting of the NF-kappaB signaling cascade with minimal toxicity, which combine with gemcitabine, can significantly enhance the antitumor capability, playing a synergistic effect.	alizarin	30-38	nuclear factor kappa B subunit 1	Homo sapiens	137-146
35541911-7	2022	Therefore, alizarin may play a role in reversing gemcitabine resistance caused by overactivated NF-kappaB in clinical application in the future.	alizarin	11-19	nuclear factor kappa B subunit 1	Homo sapiens	96-105
35125056-3	2022	Furthermore, after recombinant human PEDF treatment, the PDLF viability and osteogenic differentiation were examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay, alkaline phosphatase (ALP) activity assay, Von Kossa staining, Alizarin red staining, real-time quantitative polymerase chain reaction (qRT-PCR), and immunoblotting.	alizarin	265-277	serpin family F member 1	Homo sapiens	37-41
35038807-11	2022	The protein relative expressions of RNF11 and Akt signaling pathway were detected by Western blot, the related osteogenesis indexes were detected by Alizarin red staining, ALP staining, and qRT-PCR.	alizarin	149-161	ring finger protein 11	Homo sapiens	36-41
35025083-5	2022	The proliferation, migration and mineralization of Fam20c knockout cells were detected by CCK-8, scratch test and alizarin red staining assays.	alizarin	114-126	FAM20C, golgi associated secretory pathway kinase	Mus musculus	51-57
35038807-13	2022	The protein relative expression of RNF11 increased gradually with the extension of osteogenic differentiation time ( P<0.05); after knockdown RNF11, Alizarin red and ALP stainings showed that the degree of osteogenic differentiation of BMSCs in group C were significantly lower than those in groups A and B, and qRT-PCR detection showed that the relative expression of Runx2, OCN, and OPN mRNA significantly decreased ( P<0.05).	alizarin	149-161	ring finger protein 11	Homo sapiens	35-40
35054086-5	2022	The proliferation, osteogenic-related genes and proteins expression of MEG3 knockdown BMSCs were assessed by Cell Counting Kit-8 (CCK-8) assay, qPCR, alizarin red and alkaline phosphatase staining.	alizarin	150-162	similar to GTL2, imprinted maternally expressed untranslated	Rattus norvegicus	71-75
35054086-8	2022	The osteogenic-related genes and proteins expression of MEG3 knockdown BMSCs after wnt/beta-catenin inhibition were assessed by qPCR, alizarin red and alkaline phosphatase staining.	alizarin	134-146	similar to GTL2, imprinted maternally expressed untranslated	Rattus norvegicus	56-60
34993960-6	2022	Lastly, the regulation of the osteogenesis of human periodontal ligament stem cells (hPDLSCs) by Gremlin under inflamed condition was analyzed by alkaline phosphatase (ALP) and alizarin red staining (ARS).	alizarin	177-189	gremlin 1, DAN family BMP antagonist	Homo sapiens	97-104
34058434-8	2021	Rapamycin reversed the TNF-alpha-induced decrease in osteogenesis of BMSCs, assessed by alkaline phosphatase (ALP) activity and Alizarin staining.	alizarin	128-136	tumor necrosis factor	Homo sapiens	23-32
3814119-1	1986	Glutathione S-transferase (GST) isoenzymes isolated from human tissues and rat liver are differentially inhibited by quercetin, alizarin, purpurogallin and ellagic acid.	alizarin	128-136	glutathione S-transferase kappa 1	Homo sapiens	0-25
3814119-1	1986	Glutathione S-transferase (GST) isoenzymes isolated from human tissues and rat liver are differentially inhibited by quercetin, alizarin, purpurogallin and ellagic acid.	alizarin	128-136	glutathione S-transferase kappa 1	Homo sapiens	27-30
34032330-4	2021	RESULTS: Our results indicated that SDF-1 (50 ng/mL) promotes the osteoblastic differentiation of hBMMSCs, significantly upregulated osteoblastogenic genes (OCN, OSX, RUNX2, and ALP) and increased Alizarin red staining, alkaline phosphatase activity, and lncRNA-H19 expression.	alizarin	197-209	C-X-C motif chemokine ligand 12	Homo sapiens	36-41
33130308-6	2021	Gene expression analysis and Alizarin Red staining assay demonstrated upregulation of genes involved in odontogenic differentiation and matrix mineralization with increased calcium deposition with STIM1 overexpression.	alizarin	29-41	stromal interaction molecule 1	Mus musculus	197-202
33680105-11	2021	Significantly higher Alizarin red staining was noted for IGF-2 in the 10 ng/ml group when compared with the unloaded control at day 21 (P<0.05).	alizarin	21-33	insulin-like growth factor 2	Mus musculus	57-62
33680105-13	2021	Conclusively, the present study demonstrated that the application of IGF-2 increased alkaline phosphatase activity, Alizarin red staining, and Runx2 and Col1 expression of stem cell spheroids.	alizarin	116-128	insulin-like growth factor 2	Mus musculus	69-74
33434566-6	2021	The effect of TGF-beta1 on mineralization was analyzed by quantifying the area stained with Alizarin Red on days 7 and 14.	alizarin	92-104	transforming growth factor beta 1	Homo sapiens	14-23
33434566-9	2021	TGF-beta1 together with the mineralization medium (MM: consisting of ascorbic acid, dexamethasone and beta-glycerophosphate) increased the Alizarin Red-stained area on days 7 and 14.	alizarin	139-151	transforming growth factor beta 1	Homo sapiens	0-9
33855069-5	2021	After 14 days of osteogenic differentiation of transfected hBMSCs, the expression of osteogenic transcription factors (ALP, OCN, OPN, Runx2, and Osterix) was detected by alizarin red staining and RT-PCR.	alizarin	170-182	ATHS	Homo sapiens	119-122
33719246-5	2021	Dual-luciferase reporter (DLRTM) assay was used to verify whether miR-27a targeting Dickkopf WNT signaling pathway inhibitor 2 (DKK2) was a potential mechanism, and the mechanism was further verified by qRT-PCR, Western blot, and alizarin red staining in MC3T3-E1 cells.	alizarin	230-242	microRNA 27a	Mus musculus	66-73
33713163-6	2021	RTEF-1 significantly ameliorated beta-glycerophosphate (beta-GP)-induced VSMCs calcification, as detected by alizarin red staining and calcium content assay.	alizarin	109-121	TEA domain transcription factor 4	Homo sapiens	0-6
33212174-18	2021	S100A4 expression in cells from the dentin-pulp interface and pulp cells is consistent with the intensity of the formation of mineralized nodules detected by alizarin red staining.	alizarin	158-170	S100 calcium binding protein A4	Homo sapiens	0-6
33691396-7	2021	Alizarin red staining showed that miR-182 markedly suppressed the osteogenic differentiation of primary rat BMSCs in rats.	alizarin	0-12	microRNA 182	Rattus norvegicus	34-41
33719246-5	2021	Dual-luciferase reporter (DLRTM) assay was used to verify whether miR-27a targeting Dickkopf WNT signaling pathway inhibitor 2 (DKK2) was a potential mechanism, and the mechanism was further verified by qRT-PCR, Western blot, and alizarin red staining in MC3T3-E1 cells.	alizarin	230-242	dickkopf WNT signaling pathway inhibitor 2	Mus musculus	128-132
33421718-14	2021	BaP increased the mRNA levels of CYP1A1 and CYP1B1, while Alizarin, a CYP1s inhibitor, suppressed the effects of BaP, including the MUC5AC overexpression, ERK activation and mitochondrial ROS generation.	alizarin	58-66	bap	None	113-116
33421718-14	2021	BaP increased the mRNA levels of CYP1A1 and CYP1B1, while Alizarin, a CYP1s inhibitor, suppressed the effects of BaP, including the MUC5AC overexpression, ERK activation and mitochondrial ROS generation.	alizarin	58-66	muc5ac	None	132-138
33421718-14	2021	BaP increased the mRNA levels of CYP1A1 and CYP1B1, while Alizarin, a CYP1s inhibitor, suppressed the effects of BaP, including the MUC5AC overexpression, ERK activation and mitochondrial ROS generation.	alizarin	58-66	erk	None	155-158
33129897-5	2021	BMP9 was overexpressed in human DPCs (hDPCs), and the mineralization of hDPCs was tested by alkaline phosphatase staining and alizarin red staining.	alizarin	126-138	growth differentiation factor 2	Homo sapiens	0-4
33624201-5	2021	The mineralization potential of TNF-alpha-treated SCAP was determined by Alizarin Red staining.	alizarin	73-85	tumor necrosis factor	Homo sapiens	32-41
33624201-5	2021	The mineralization potential of TNF-alpha-treated SCAP was determined by Alizarin Red staining.	alizarin	73-85	SREBF chaperone	Homo sapiens	50-54
33478200-8	2021	The expression of Runx2 gene in cells in all groups was detected by Real-time PCR; the expression of Runx2 protein was detected by Western blot and immunocytochemistry; the activity of ALP was detected by reagent kit method; osteogenic differentiation was analyzed by alizarin red staining.	alizarin	268-280	runt related transcription factor 2	Mus musculus	18-23
33478200-8	2021	The expression of Runx2 gene in cells in all groups was detected by Real-time PCR; the expression of Runx2 protein was detected by Western blot and immunocytochemistry; the activity of ALP was detected by reagent kit method; osteogenic differentiation was analyzed by alizarin red staining.	alizarin	268-280	runt related transcription factor 2	Mus musculus	101-106
33404136-7	2022	Knockdown ITGalpha6 decreased the expression of stemness markers, CD105 and STRO-1 in hDPSCs, but promoted the osteogenic and odontogenic differentiation by increased ALP expression and alizarin red nodules.	alizarin	186-198	integrin subunit alpha 6	Homo sapiens	10-19
33198129-8	2020	Alizarin red staining was positive 21 days after the start of induction, with significantly higher Runt-related transcription factor 2 (Runx2) and osteocalcin (OCN) expression levels than those in the controls.	alizarin	0-12	RUNX family transcription factor 2	Rattus norvegicus	99-134
33392201-7	2020	Primary murine CD11b KO chondrocytes showed increased mineralization when induced in vitro by secondary calciprotein particles (CPP) and quantified by Alizarin Red staining.	alizarin	151-163	integrin alpha M	Mus musculus	15-20
33296134-5	2021	Lipopolysaccharide at 1 and 5 microg mL-1 increased Alizarin red staining in apical papilla cells from early-stage but not the late-stage cells.	alizarin	52-64	L1 cell adhesion molecule	Mus musculus	37-41
32920731-6	2021	FOXO3 and ALP levels were increased in a time-dependent manner with osteogenic differentiation, supported by Alizarin Red Staining.	alizarin	109-121	forkhead box O3	Homo sapiens	0-5
32920731-6	2021	FOXO3 and ALP levels were increased in a time-dependent manner with osteogenic differentiation, supported by Alizarin Red Staining.	alizarin	109-121	alkaline phosphatase, placental	Homo sapiens	10-13
33282557-9	2020	Wnt16 shRNA reduced mRNA expression of Runx2, collage type I (Col-1) and osteocalcin (OCN) after 7 days of osteogenic induction, as well as alizarin red staining intensity after 21days.	alizarin	140-152	wingless-type MMTV integration site family, member 16	Mus musculus	0-5
33198129-8	2020	Alizarin red staining was positive 21 days after the start of induction, with significantly higher Runt-related transcription factor 2 (Runx2) and osteocalcin (OCN) expression levels than those in the controls.	alizarin	0-12	RUNX family transcription factor 2	Rattus norvegicus	136-141
33198129-8	2020	Alizarin red staining was positive 21 days after the start of induction, with significantly higher Runt-related transcription factor 2 (Runx2) and osteocalcin (OCN) expression levels than those in the controls.	alizarin	0-12	bone gamma-carboxyglutamate protein	Rattus norvegicus	147-158
33198129-8	2020	Alizarin red staining was positive 21 days after the start of induction, with significantly higher Runt-related transcription factor 2 (Runx2) and osteocalcin (OCN) expression levels than those in the controls.	alizarin	0-12	bone gamma-carboxyglutamate protein	Rattus norvegicus	160-163
32868075-4	2020	The results of Alizarin red and Alcian blue staining showed that PLCgamma1 inhibitor U73122 significantly enhanced the mineralization capacity and proteoglycan deposition of BMSCs.	alizarin	15-27	phospholipase C, gamma 1	Rattus norvegicus	65-74
33177854-5	2020	After treating SMCs with MVs and Anti-Sortilin, cell calcification was observed by Alizarin red staining.	alizarin	83-95	sortilin 1	Mus musculus	38-46
33543213-5	2020	The expression of mineralized nodules and osteogenesis-related gene Runx2 was observed by alizarin red staining.	alizarin	90-102	runt related transcription factor 2	Mus musculus	68-73
32747254-0	2020	CMC and CNF-based alizarin incorporated reversible pH-responsive color indicator films.	alizarin	18-26	NPHS1 adhesion molecule, nephrin	Homo sapiens	8-11
33082788-4	2020	By an alkaline phosphatase (ALP) activity assay, Alizarin red staining, real-time RT-PCR, and western blot analysis, we found that KDM3B enhanced the ALP activity and mineralization of SCAPs and promoted the expression of runt-related transcription factor 2 (RUNX2), osterix (OSX), dentin sialophosphoprotein (DSPP), and osteocalcin (OCN).	alizarin	49-61	lysine demethylase 3B	Homo sapiens	131-136
32428889-7	2020	Alizarin Red staining showed that the BMP peptide construct group exhibited the highest calcification as compared to the growth medium, osteogenic medium and non-BMP peptide construct groups.	alizarin	0-12	bone morphogenetic protein 1	Homo sapiens	38-41
32384955-11	2020	In addition, ALP activity test and alizarin red staining showed that reduced expression of DNMT1 resulted in an increase in OPG/RANKL ratio and promoted the differentiation of the precursor cells.	alizarin	35-47	DNA methyltransferase 1	Homo sapiens	91-96
33029150-8	2020	Also, quantitative Alizarin Red staining representing ECM mineralization was significantly decreased under MRTF-A inhibition.	alizarin	19-31	myocardin related transcription factor A	Homo sapiens	107-113
33013696-14	2020	In a culture of osteoblasts isolated from neonatal rat calvariae, the calcitonin-treated osteoclast supernatant showed an increase in mineralization, as indicated by ALP and alizarin red staining.	alizarin	174-186	calcitonin-related polypeptide alpha	Rattus norvegicus	70-80
32574664-5	2020	In fact, it facilitates ALP activity and accumulation of calcium in osteoblast; it was confirmed by Alizarin red and von Kossa staining.	alizarin	100-112	PDZ and LIM domain 3b	Danio rerio	24-27
32706234-8	2020	Sustained BMP2 release from h-MnO2 promoted osteogenesis by accelerating the osteogenic differentiation of recruited SSCs, as demonstrated by ALP and alizarin red staining in vitro and Micro-CT in vivo.	alizarin	150-162	bone morphogenetic protein 2	Mus musculus	10-14
32460636-6	2020	In vitro, anti-DKK1 treatment, but not anti-Sclerostin (SOST), promoted ASC osteogenic differentiation, assessed by alizarin red staining and qRT-PCR.	alizarin	116-128	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	15-19
32253621-8	2020	Cell differentiation of CD14+PBMCs and C2C12 cells were detected by tartrate-resistant acid phosphatase (TRAP) staining and alizarin red staining, respectively.	alizarin	124-136	CD14 antigen	Mus musculus	24-28
32332097-5	2020	Co-administration of BMP2 with the EZH2 inhibitor GSK126 enhanced differentiation of murine (MC3T3) osteoblasts, reflected by increased alkaline phosphatase activity, alizarin red staining, and expression of bone-related marker genes (e.g. Bglap and Phospho1).	alizarin	167-179	bone morphogenetic protein 2	Mus musculus	21-25
32349184-8	2020	In the conventional OS cell-line Saos2 and in patient-derived xenograft OS (PDX-OS) cells, increased PLK2 expression owing to abundant TAp73 levels affected OPN and OCN content as measured by RT-PCR and Western blotting, and alizarin red staining showed that PLK2 affected calcium deposition in OS cells.	alizarin	225-237	polo like kinase 2	Homo sapiens	101-105
31797525-12	2020	Alizarin Red staining revealed enhanced mineralization in 50 muM NaF treated BMMSCs with increased expression of Runx2 and Osteocalcin, indicating their upregulated osteogenic differentiation.	alizarin	0-12	RUNX family transcription factor 2	Rattus norvegicus	113-118
31797525-12	2020	Alizarin Red staining revealed enhanced mineralization in 50 muM NaF treated BMMSCs with increased expression of Runx2 and Osteocalcin, indicating their upregulated osteogenic differentiation.	alizarin	0-12	bone gamma-carboxyglutamate protein	Rattus norvegicus	123-134
32719987-9	2020	The ALP activity and Alizarin red staining were significantly decreased by miR-34a in hMSCs.	alizarin	21-33	microRNA 34a	Homo sapiens	75-82
32299243-9	2021	RESULTS: Overexpressing HOXA10 inhibited PDLSC osteogenic differentiation in vitro, shown by ALP and Alizarin Red staining, while HOXA10 knockdown demonstrated the opposite effects.	alizarin	101-113	homeobox A10	Homo sapiens	24-30
32056303-9	2020	By detecting osteogenic-specific molecule expression, alkaline phosphatase activity, and alizarin red staining, miR-22 was observed to suppress osteogenic differentiation of MC3T3-E1 cells.	alizarin	89-101	microRNA 22	Mus musculus	112-118
32406256-11	2021	Trilineage differentiation was seen in both groups with higher alizarin red uptake noted in hPL.	alizarin	63-75	galectin 1	Homo sapiens	92-95
31897529-7	2020	In addition, we verified the effects of ALKBH5 on osteogenesis using alizarin red and ALP staining.	alizarin	69-81	alkB homolog 5, RNA demethylase	Homo sapiens	40-46
31622505-6	2020	The osteo/odontogenic differentiation of hSCAP was evaluated by qPCR, Western blot and Alizarin red S staining.	alizarin	87-95	SREBF chaperone	Homo sapiens	41-46
32226529-6	2020	Moreover, the mechanisms by which IL-12 and IL-23 regulated the differentiation of BMMSCs and RAW264.7 cells were explored using Alizarin Red and tartrate-resistant acid phosphatase staining in vitro.	alizarin	129-141	interleukin 23, alpha subunit p19	Mus musculus	44-49
32355520-4	2020	The expression of osteocalcin and alkaline phosphatase were detected by alizarin red staining and ELISA.	alizarin	72-84	bone gamma-carboxyglutamate protein	Homo sapiens	18-29
31813723-1	2020	A new ratiometric fluorescent strategy for detection of alizarin red (ARS) was designed based on the fluorescence of CDs and scattered light of scatterer.	alizarin	56-68	RIEG2	Homo sapiens	70-73
31465741-5	2020	Although Z and AZ each inhibited in vitro matrix metallopeptidase (MMP)-1, MMP-3, and MMP-12 activity, inhibition of MMP-3 and MMP-12 was greater with AZ.	alizarin	15-17	matrix metallopeptidase 1	Homo sapiens	42-73
31465741-5	2020	Although Z and AZ each inhibited in vitro matrix metallopeptidase (MMP)-1, MMP-3, and MMP-12 activity, inhibition of MMP-3 and MMP-12 was greater with AZ.	alizarin	15-17	matrix metallopeptidase 3	Homo sapiens	75-80
31465741-5	2020	Although Z and AZ each inhibited in vitro matrix metallopeptidase (MMP)-1, MMP-3, and MMP-12 activity, inhibition of MMP-3 and MMP-12 was greater with AZ.	alizarin	15-17	matrix metallopeptidase 12	Homo sapiens	86-92
31465741-5	2020	Although Z and AZ each inhibited in vitro matrix metallopeptidase (MMP)-1, MMP-3, and MMP-12 activity, inhibition of MMP-3 and MMP-12 was greater with AZ.	alizarin	151-153	matrix metallopeptidase 12	Homo sapiens	127-133
32030959-19	2020	Alizarin red staining showed that the application of ATRA or Ad-VEGF induced weak calcium salt deposition, and the combined use of ATRA and Ad-VEGF significantly enhanced the effect of calcium salt deposition in MEFs.	alizarin	0-8	vascular endothelial growth factor A	Mus musculus	64-68
32734173-8	2020	However, Alizarin S data demonstrated higher mineralization by Day 21 and the effect was amplified in BMP2-modified matrices.	alizarin	9-17	bone morphogenetic protein 2	Homo sapiens	102-106
32050954-5	2020	Characteristics of SCAP were confirmed by Flow cytometric (FCM) analysis and alizarin red staining.	alizarin	77-89	SREBF chaperone	Homo sapiens	19-23
32030959-19	2020	Alizarin red staining showed that the application of ATRA or Ad-VEGF induced weak calcium salt deposition, and the combined use of ATRA and Ad-VEGF significantly enhanced the effect of calcium salt deposition in MEFs.	alizarin	0-8	vascular endothelial growth factor A	Mus musculus	143-147
32016954-5	2020	In addition, the changes in ALP activity and calcification ability in hMSCs influenced by them were assessed through ALP activity determination and alizarin red staining, respectively.	alizarin	148-160	alkaline phosphatase, placental	Homo sapiens	28-31
31952480-4	2020	Moreover, alizarin red staining and qRT-PCR analysis revealed that TNFalpha produced by BV2 cells was the key promoting factor of VSMC calcification.	alizarin	10-22	tumor necrosis factor	Mus musculus	67-75
31900200-11	2020	Overexpression of FER1L4 promoted the osteogenic differentiation of PDLSCs, as revealed by alkaline phosphatase activity, Alizarin red S staining, and the expression of osteogenic markers, whereas FER1L4 knockdown inhibited these processes.	alizarin	122-130	fer-1 like family member 4 (pseudogene)	Homo sapiens	18-24
31448831-10	2020	Additionally, the overexpression of USF2 promoted osteoblast-specific gene expression and the Alizarin red staining of PDLCs, while simultaneously overexpressing USF2 and silencing ATF4 reversed the favorable osteogenic effect of the induced-PDLCs by reducing osteoblast-specific gene expression and the Alizarin red staining level.	alizarin	304-316	activating transcription factor 4	Homo sapiens	181-185
31949435-8	2019	Alizarin Red staining of insulin-treated TPC osteogenic cultures demonstrated robust cell aggregation and mineralized matrix secretion, in a dose-dependent manner.	alizarin	0-12	insulin	Homo sapiens	25-32
31920993-10	2019	The alkaline phosphatase assay and Alizarin Red S staining showed that overexpressed MGP led to prominently upregulated differentiation and mineralization of MG63 cells.	alizarin	35-47	matrix Gla protein	Homo sapiens	85-88
31867409-2	2019	The population dynamics in the solute vibrational mode of nuC=O and the coherent oscillations observed in all of the skeletal vibrational modes nuC=O and nuC=C clearly showed the ultrafast excited-state intramolecular proton transfer dynamics of 110 and 170 fs for alizarin-h2 and alizarin-d2, respectively.	alizarin	265-273	nucleobindin 1	Homo sapiens	58-61
31867409-2	2019	The population dynamics in the solute vibrational mode of nuC=O and the coherent oscillations observed in all of the skeletal vibrational modes nuC=O and nuC=C clearly showed the ultrafast excited-state intramolecular proton transfer dynamics of 110 and 170 fs for alizarin-h2 and alizarin-d2, respectively.	alizarin	265-273	nucleobindin 1	Homo sapiens	144-147
31867409-2	2019	The population dynamics in the solute vibrational mode of nuC=O and the coherent oscillations observed in all of the skeletal vibrational modes nuC=O and nuC=C clearly showed the ultrafast excited-state intramolecular proton transfer dynamics of 110 and 170 fs for alizarin-h2 and alizarin-d2, respectively.	alizarin	265-273	nucleobindin 1	Homo sapiens	144-147
31867409-2	2019	The population dynamics in the solute vibrational mode of nuC=O and the coherent oscillations observed in all of the skeletal vibrational modes nuC=O and nuC=C clearly showed the ultrafast excited-state intramolecular proton transfer dynamics of 110 and 170 fs for alizarin-h2 and alizarin-d2, respectively.	alizarin	281-292	nucleobindin 1	Homo sapiens	58-61
31867409-2	2019	The population dynamics in the solute vibrational mode of nuC=O and the coherent oscillations observed in all of the skeletal vibrational modes nuC=O and nuC=C clearly showed the ultrafast excited-state intramolecular proton transfer dynamics of 110 and 170 fs for alizarin-h2 and alizarin-d2, respectively.	alizarin	281-292	nucleobindin 1	Homo sapiens	144-147
31867409-2	2019	The population dynamics in the solute vibrational mode of nuC=O and the coherent oscillations observed in all of the skeletal vibrational modes nuC=O and nuC=C clearly showed the ultrafast excited-state intramolecular proton transfer dynamics of 110 and 170 fs for alizarin-h2 and alizarin-d2, respectively.	alizarin	281-292	nucleobindin 1	Homo sapiens	144-147
31522346-5	2019	Then, the expression levels of Postn and osteogenesis in OVX-BMMSCs were detected by alizarin red and alkaline phosphatase substrate staining, qPCR, and western blotting.	alizarin	85-97	periostin	Rattus norvegicus	31-36
31874485-9	2019	Alizarin red staining induced by osteogenesis at 2 weeks and 3 weeks showed that the staining of PRDM9sh was significantly lighter than that in control group.	alizarin	0-12	PR/SET domain 9	Homo sapiens	97-102
31816999-8	2019	Moreover, the plant-produced hDMP1 promoted calcium deposition in hPDLSCs as determined by alizarin red S staining.	alizarin	91-99	dentin matrix acidic phosphoprotein 1	Homo sapiens	29-34
31397884-6	2019	Alizarin red staining and calcium content assay revealed that adenovirus-mediated CDC42 overexpression led to an apparent VSMC calcification in the presence of calcifying medium, accompanied with up-regulation of bone-related molecules including RUNX2 and BMP2.	alizarin	0-12	cell division cycle 42	Rattus norvegicus	82-87
31448831-10	2020	Additionally, the overexpression of USF2 promoted osteoblast-specific gene expression and the Alizarin red staining of PDLCs, while simultaneously overexpressing USF2 and silencing ATF4 reversed the favorable osteogenic effect of the induced-PDLCs by reducing osteoblast-specific gene expression and the Alizarin red staining level.	alizarin	94-106	upstream transcription factor 2, c-fos interacting	Homo sapiens	36-40
31448831-10	2020	Additionally, the overexpression of USF2 promoted osteoblast-specific gene expression and the Alizarin red staining of PDLCs, while simultaneously overexpressing USF2 and silencing ATF4 reversed the favorable osteogenic effect of the induced-PDLCs by reducing osteoblast-specific gene expression and the Alizarin red staining level.	alizarin	304-316	upstream transcription factor 2, c-fos interacting	Homo sapiens	36-40
31173907-10	2019	Vital staining of gpr137ba-/- fish with calcein and alizarin red indicated that bone formation in the mutants is also increased, suggesting high bone turnover.	alizarin	52-64	G protein-coupled receptor 137c	Danio rerio	18-26
31551149-4	2019	Meanwhile, regulatory effect of MSC-AS1 on osteogenic differentiation was detected through ALP staining and alizarin red staining.	alizarin	108-120	arylsulfatase B	Mus musculus	36-39
31539111-11	2019	Alkaline phosphatase staining and alizarin red staining showed that miR-373 could promote the differentiation of bone marrow mesenchymal stem cells into osteoblasts and reverse the decreased osteogenic differentiation of bone marrow mesenchymal stem cells caused by osteoporosis.	alizarin	34-46	microRNA 373	Homo sapiens	68-75
31410150-10	2019	Following the induction of osteogenesis and staining with alizarin red, the level of AKP was significantly higher in cells in the siRNA-Notch1 and gamma-secretase inhibitor groups compared with that in the control group.	alizarin	58-70	notch 1	Mus musculus	136-142
30618207-5	2019	Alkaline phosphatase (ALP) activity assays and alizarin red staining showed that RAMP1 promoted osteogenic differentiation of BMSCs after calcitonin gene-related peptide (CGRP) treatment (10 -8  mol/L).	alizarin	47-59	receptor activity modifying protein 1	Homo sapiens	81-86
31331833-11	2019	ALP activity and Alizarin Red staining showed IL-13 and IL-17A dose-dependent osteoblast differentiation and mineralisation in vitro.	alizarin	17-29	interleukin 13	Homo sapiens	46-51
31331833-11	2019	ALP activity and Alizarin Red staining showed IL-13 and IL-17A dose-dependent osteoblast differentiation and mineralisation in vitro.	alizarin	17-29	interleukin 17A	Homo sapiens	56-62
30618072-4	2019	YAP1 overexpression MC3T3-E1 showed increased expression of osteogenesis markers, such as runt-related transcription factor 2, osteocalcin, and osteopontin, as well as alkaline phosphatase and alizarin red staining.	alizarin	193-205	yes-associated protein 1	Mus musculus	0-4
30579537-12	2019	Finally, alizarin red staining showed that HDAC6 inhibition promoted osteoblastic differentiation of VICs, which could be suppressed by tauroursodeoxycholic acid.	alizarin	9-21	histone deacetylase 6	Homo sapiens	43-48
31281386-12	2019	Dexamethasone and DAPT could downregulate the high expression of Notch4, Hes1, Hey2 and upregulate the low expression of Runx2 in BMSCs which cocultured with LPS treated B lymphocytes, the inhibited ALP and Alizarin red staining in BMSCs which cocultured with LPS treated B lymphocytes also partly restored.	alizarin	207-219	RUNX family transcription factor 2	Rattus norvegicus	121-126
30813067-10	2019	Alizarin red stainings indicated that the nanoporous surfaces stimulated the osteogenic differentiation of hMSC.	alizarin	0-12	musculin	Homo sapiens	107-111
30910359-7	2019	MST2 and SAV1 also hampered osteoblast differentiation of C2C12 cells induced by Runx2 as shown by alkaline phosphatase activity assay and Alizarin Red staining.	alizarin	139-151	serine/threonine kinase 3	Mus musculus	0-4
30910359-7	2019	MST2 and SAV1 also hampered osteoblast differentiation of C2C12 cells induced by Runx2 as shown by alkaline phosphatase activity assay and Alizarin Red staining.	alizarin	139-151	salvador family WW domain containing 1	Mus musculus	9-13
30914419-6	2019	Axonal transport of synaptic cargo via the lysosomal kinesin adapter Arl8 regulates AZ abundance to modulate global synaptic output and sustain the homeostatic potentiation of neurotransmission.	alizarin	84-86	ADP ribosylation factor-like 8	Drosophila melanogaster	69-73
30885436-7	2019	In addition, inhibition of Ctrp4 resulted in decreased alkaline phosphatase expression and less alizarin red staining, indicating that Ctrp4 promoted osteogenic differentiation and osteoblasts mineralization.	alizarin	96-108	C1q and tumor necrosis factor related protein 4	Mus musculus	27-32
30885436-7	2019	In addition, inhibition of Ctrp4 resulted in decreased alkaline phosphatase expression and less alizarin red staining, indicating that Ctrp4 promoted osteogenic differentiation and osteoblasts mineralization.	alizarin	96-108	C1q and tumor necrosis factor related protein 4	Mus musculus	135-140
30804229-6	2019	Furthermore, miR-206 overexpressing BMSCs showed attenuated alkaline phosphatase (ALP) activity, Alizarin Red staining, and osteocalcin secretion.	alizarin	97-109	microRNA 206	Homo sapiens	13-20
30738636-5	2019	The samples of UCB that were added with cryopreserved UCB-PRP and those with bone morphogenetic protein-2 were stained granularly with Alizarin red, thus indicating the presence of calcium.	alizarin	135-147	bone morphogenetic protein 2	Homo sapiens	77-105
30769016-7	2019	A reduction in endogenous CaSR expression by hVICs (using siRNA) was associated with significantly lower levels of Ca2+-induced mineralization (quantified using Alizarin Red staining).	alizarin	161-173	calcium sensing receptor	Homo sapiens	26-30
30816502-8	2019	Alizarin red staining demonstrated a decrease in biomineralization activity following the inhibition of CXCR4.	alizarin	0-12	C-X-C motif chemokine receptor 4	Homo sapiens	104-109
30650995-0	2019	Alizarin increase glucose uptake through PI3K/Akt signaling and improve alloxan-induced diabetic mice.	alizarin	0-8	thymoma viral proto-oncogene 1	Mus musculus	46-49
30650995-4	2019	AZ could significantly improve the glucose uptake of 3T3-L1 adipocytes under insulin resistance, and could also increase GLUT4 protein expression levels, IRS-1 and Akt protein phosphorylation.	alizarin	0-2	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	121-126
30650995-4	2019	AZ could significantly improve the glucose uptake of 3T3-L1 adipocytes under insulin resistance, and could also increase GLUT4 protein expression levels, IRS-1 and Akt protein phosphorylation.	alizarin	0-2	insulin receptor substrate 1	Mus musculus	154-159
30650995-4	2019	AZ could significantly improve the glucose uptake of 3T3-L1 adipocytes under insulin resistance, and could also increase GLUT4 protein expression levels, IRS-1 and Akt protein phosphorylation.	alizarin	0-2	thymoma viral proto-oncogene 1	Mus musculus	164-167
30773540-12	2019	After hDPCs were cultured on the two different collagen scaffolds with odontoblastic medium for 14 days, more expressions of odontoblastic differentiation related genes, such as dentin sialophosphoprotein (DSPP) and dentin matrix proten-1 (DMP1) were determined in Col_NFM group (P&lt;0.05), and more mineralization depositions were also observed in Col_NFM group according to the results of alizarin red staining.	alizarin	392-404	dentin sialophosphoprotein	Homo sapiens	206-210
30834083-5	2019	Using siRNA and overexpression, we investigated the role of hub gene BRCC3 in osteogenic differentiation by alkaline phosphatase staining and Alizarin red staining.	alizarin	142-154	ELAV like RNA binding protein 2	Homo sapiens	60-63
30696833-6	2019	Activation of SIRT1 by SRT1720 reduced Alizarin red staining by a third, via inhibition of the RUNX2 pathway and prevention of senescence.	alizarin	39-51	sirtuin 1	Homo sapiens	14-19
30300698-1	2019	The osteogenetic potential of photo-immobilized azdiophenyl (Az)-natural polymers as a carrier of bone morphogenetic protein-2 (BMP-2) was assessed in 56 rats randomized to four groups.	alizarin	61-63	bone morphogenetic protein 2	Rattus norvegicus	128-133
30720149-11	2019	The results of alizarin red staining showed that the deposition of calcium obviously increased in miR-146a-mimic group compared with that in miR-NC group, indicating that the osteogenic differentiation ability is significantly enhanced, while it markedly decreased in miR-146a-inhibitor group compared with that in miR-NC group.	alizarin	15-27	microRNA 146a	Homo sapiens	98-106
30391791-11	2019	ALP activity, ALP staining and alizarin red staining results indicated that mutant RUNX2 decreased the mineralization ability of DFCs.	alizarin	31-43	RUNX family transcription factor 2	Homo sapiens	83-88
30277257-5	2018	Here, we describe the skeletal defects of meox1cho mutant zebrafish utilising alizarin red to stain bones and chemical maceration of soft tissue to detect fusions in an unbiased manner.	alizarin	78-90	mesenchyme homeobox 1	Danio rerio	42-47
31272281-6	2019	Alizarin Red staining was used to detect the influence of ATP6V1H on osteogenic differentiation.	alizarin	0-12	ATPase, H+ transporting, lysosomal V1 subunit H	Mus musculus	58-65
30590908-6	2018	Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to upregulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules.	alizarin	262-274	RUNX family transcription factor 2	Homo sapiens	203-209
30590908-6	2018	Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to upregulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules.	alizarin	262-274	bone gamma-carboxyglutamate protein	Homo sapiens	214-225
29694681-7	2018	Calcein and Alizarin Red double labeling revealed more mineralized areas in Anxa5-/- mice than WT mice.	alizarin	12-24	annexin A5	Mus musculus	76-81
30396234-6	2018	Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to upregulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules.	alizarin	262-274	RUNX family transcription factor 2	Homo sapiens	203-209
30396234-6	2018	Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to upregulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules.	alizarin	262-274	bone gamma-carboxyglutamate protein	Homo sapiens	214-225
30515223-8	2018	Results: TNF-alpha stimulation of PDLSCs decreased alkaline phosphatase and alizarin red staining, alkaline phosphatase activity, and mRNA expression of RUNX2, OCN, and BSP in osteogenic-conditioned medium.	alizarin	76-88	tumor necrosis factor	Homo sapiens	9-18
30356078-3	2018	Analysis of alkaline phosphatase activity, von Kossa staining, Alizarin Red quantification, and osteogenic gene expression, indicates a significant synergistic effect between the PA-RGDS nanomatrix and coculture that promoted hMSC osteogenesis.	alizarin	63-75	ral guanine nucleotide dissociation stimulator	Homo sapiens	179-186
30012486-3	2018	The effect of PV on the mineralization of MC3T3-E1 was monitored using the Alizarin-red staining.	alizarin	75-87	casein kinase 2, beta polypeptide	Mus musculus	14-16
30032718-6	2018	These deleted Ihh/GFP-positive cells isolated from Prx1-Cre;Ihhfl/fl;Rosa26-ZsGreen1 newborn mice had osteogenic differentiation by showing a positive Alizarin red and von Kossa staining, as well as an enhanced Col1a1, osteocalcin, and Runx2 expression.	alizarin	151-163	Indian hedgehog	Mus musculus	14-17
29932916-4	2018	FGF21 inhibited beta-glycerophosphate (BGP) induced mineralization in VSMCs as determined by calcium concentration and Alizarin Red S. FGF21 suppressed BGP-induced BMP2/Smad signaling pathway components as well as osteoblast differentiation markers.	alizarin	119-131	fibroblast growth factor 21	Homo sapiens	0-5
29932916-4	2018	FGF21 inhibited beta-glycerophosphate (BGP) induced mineralization in VSMCs as determined by calcium concentration and Alizarin Red S. FGF21 suppressed BGP-induced BMP2/Smad signaling pathway components as well as osteoblast differentiation markers.	alizarin	119-131	fibroblast growth factor 21	Homo sapiens	135-140
30147726-5	2018	Moreover, SCAP-Foxc2-BMP2 formed notably more alkaline phosphatase-positive and alizarin red-positive mineralized nodules than other three group cells sixteen days after transfection.	alizarin	80-92	SREBF chaperone	Homo sapiens	10-14
29247276-12	2018	Lentivirus-induced BDNF-AS upregulation promoted BMMSCs self-proliferation but inhibited osteogenic differentiation, as demonstrated by proliferation, alizarin red staining, and alkaline phosphatase activity assays, respectively.	alizarin	151-163	brain derived neurotrophic factor	Mus musculus	19-23
30147726-5	2018	Moreover, SCAP-Foxc2-BMP2 formed notably more alkaline phosphatase-positive and alizarin red-positive mineralized nodules than other three group cells sixteen days after transfection.	alizarin	80-92	forkhead box C2	Homo sapiens	15-20
30147726-5	2018	Moreover, SCAP-Foxc2-BMP2 formed notably more alkaline phosphatase-positive and alizarin red-positive mineralized nodules than other three group cells sixteen days after transfection.	alizarin	80-92	bone morphogenetic protein 2	Homo sapiens	21-25
30043563-9	2018	In addition, the Western blot results showed that the expression of RUNX2 (Runt-related transcription factor 2) protein in group B was 1.254 times of that in group A and 2.636 times of that in group C. Furthermore, alizarin red staining showed that the ratios of calcium salt deposition area to the total area in group A, group B and group C were 0.208%, 3.469%, and 20.724%, respectively.	alizarin	215-227	runt related transcription factor 2	Mus musculus	68-73
29999239-4	2018	Importantly, we found that orexin-A accelerated osteoblast differentiation and matrix mineralization in MC3T3-E1 cells, as manifested by elevation of physiological markers of osteoblastic differentiation [alkaline phosphatase (ALP) and osteogenic genes] and Alizarin Red staining, respectively.	alizarin	258-270	hypocretin	Mus musculus	27-35
29637597-10	2018	In addition, alkaline phosphatase (ALP) and Alizarin Red staining confirmed that Dnmt3b deletion in chondrocytes delays in vitro chondrocyte hypertrophic differentiation and matrix mineralization.	alizarin	44-56	DNA methyltransferase 3B	Mus musculus	81-87
29555587-11	2018	Alizarin red staining confirmed formation of mineralized nodules 4 weeks after BMP-7 induction.	alizarin	0-12	bone morphogenetic protein 7	Homo sapiens	79-84
29913147-10	2018	Overexpression of lncRNA-ANCR decreased the expression of ALP, RUNX2 and OSX as confirmed by Alizarin red staining.	alizarin	93-105	Angelman syndrome chromosome region	Homo sapiens	25-29
29913147-10	2018	Overexpression of lncRNA-ANCR decreased the expression of ALP, RUNX2 and OSX as confirmed by Alizarin red staining.	alizarin	93-105	alkaline phosphatase, placental	Homo sapiens	58-61
29913147-10	2018	Overexpression of lncRNA-ANCR decreased the expression of ALP, RUNX2 and OSX as confirmed by Alizarin red staining.	alizarin	93-105	Sp7 transcription factor	Homo sapiens	73-76
29643528-14	2018	After 21 days of osteogenic induction, alizarin red staining and qPCR showed that the CD146 positive cell population had more mineralized nodule formation and expressed higher level of osteogenic related genes compared with the other two groups.	alizarin	39-51	melanoma cell adhesion molecule	Homo sapiens	86-91
30043563-9	2018	In addition, the Western blot results showed that the expression of RUNX2 (Runt-related transcription factor 2) protein in group B was 1.254 times of that in group A and 2.636 times of that in group C. Furthermore, alizarin red staining showed that the ratios of calcium salt deposition area to the total area in group A, group B and group C were 0.208%, 3.469%, and 20.724%, respectively.	alizarin	215-227	runt related transcription factor 2	Mus musculus	75-110
29268145-2	2018	DESIGN: The effect of recombinant human WNT7B (rhWNT7B) on the proliferation and migration of HDPCs was evaluated by 5-ethynyl-2"-deoxyuridine (EdU), immunofluorescence staining of Ki67, flow cytometry and scratch assay; the differentiation of HDPCs was measured by alkaline phosphatase (ALP) staining, alizarin red staining, ALP activity, qPCR and western blot.	alizarin	303-315	Wnt family member 7B	Homo sapiens	40-45
29212377-8	2018	Quantitative analysis of extracellular deposition of calcium (Alizarin red) and alkaline phosphatase activity showed that BMP-2-transduced cells had a higher osteogenic differentiation capacity compared to non-transduced cells.	alizarin	62-74	bone morphogenetic protein 2	Homo sapiens	122-127
29207066-5	2018	Using Alizarin Red and ALP staining, it was demonstrated that Epo exerted positive osteogenic effects on hPDLSCs and pPDLSCs.	alizarin	6-18	erythropoietin	Homo sapiens	62-65
28688217-7	2018	The YAP1 overexpression group showed higher intensities of ALP and Alizarin red stain than the YAP1-knockdown group.	alizarin	67-79	Yes1 associated transcriptional regulator	Homo sapiens	4-8
29106055-3	2018	Then the function of lnc-NTF3-5 was evaluated by loss- and gain-of-function techniques, as well as qRT-PCR, western blot, and Alizarin Red staining.	alizarin	126-138	neurotrophin 3	Homo sapiens	25-29
28681925-4	2018	We found that Wnt5a suppressed expression of bone-related genes (ALP, BSP, and Osterix) and alizarin red-positive mineralized nodule formation in HPDLSCs under osteogenic conditions.	alizarin	92-104	Wnt family member 5A	Homo sapiens	14-19
28681925-10	2018	Additionally, SP600125 inhibited the Wnt5a-induced suppression of the alizarin red-positive reaction in HPDLSCs.	alizarin	70-82	Wnt family member 5A	Homo sapiens	37-42
33177016-7	2018	Alizarin Red staining showed that the cells seeded on the noggin siRNA-loading collagen/bioglass scaffold contained significantly more mineralized nodules than the other cells (P < 0.05).	alizarin	0-12	noggin	Mus musculus	58-64
29316656-1	2018	Azemiopsin (Az), a linear peptide from the Azemiops feae viper venom, contains no disulfide bonds, is a high-affinity and selective inhibitor of nicotinic acetylcholine receptor (nAChR) of muscle type and may be considered as potentially applicable nondepolarizing muscle relaxant.	alizarin	0-2	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	179-184
27696748-8	2018	Alizarin red staining showed that PDGF-BB promoted significantly more mineral deposition than BMP2.	alizarin	0-12	bone morphogenetic protein 2	Homo sapiens	94-98
29595457-6	2018	Results Compared with the inflammatory control group, the proliferative activity of hBMSCs in NT-3 group significantly increased, the apoptosis obviously decreased, and the contents of RUNX2 and ALP, as well as the intensity of alizarin red staining in NT-3 group evidently rose.	alizarin	228-240	neurotrophin 3	Homo sapiens	253-257
29143345-4	2017	In the present study, alkaline phosphatase activity, alizarin red-positive mineralization, and calcium content, positive indicators of osteogenic differentiation, were significantly higher in cultured human periosteum-derived cells (hPDCs) with Lin28a overexpression compared with cells without Lin28a overexpression.	alizarin	53-65	lin-28 homolog A	Homo sapiens	245-251
28691816-1	2017	Mechanisms of excited-state intramolecular proton transfer (ESIPT) of 1,2-dihydroxyanthraquinone (ALR) in ethanol solvent and binary solvent of water and ethanol are investigated using the density functional theory and time-dependent density functional theory.	alizarin	70-96	growth factor, augmenter of liver regeneration	Homo sapiens	98-101
27909893-5	2017	Thereafter, the cellular effects of ST2 pre-osteoblasts were investigated for cellular attachment at 8 h and cell proliferation at 1, 3, and 5 days as well as osteoblast differentiation by real-time PCR and alizarin red staining for cells seeded on (1) tissue culture plastic, (2) ACS alone, and (3) ACS + Osteogain .	alizarin	207-219	ST2	Homo sapiens	36-39
29089766-10	2017	With the prolonged local retention and interaction duration of BMP2 and IC, the SFBMP2/SBA15IC scaffold provided better osteogenic differentiation than other groups with different loading modes of BMP2 or IC, as determined by ALP staining and quantitation and Alizarin red staining.	alizarin	260-272	bone morphogenetic protein 2	Homo sapiens	82-86
28419546-8	2017	Consistent with this finding, Alizarin red/Alcian blue staining of 2-day-old Gja1+/- Runx2+/- neonates showed a hypomorphic interparietal bone, an exacerbation of the open fontanelles, and a further reduction in the hypoplastic clavicles compared to Runx2+/- neonates.	alizarin	30-42	gap junction protein, alpha 1	Mus musculus	77-81
28419546-8	2017	Consistent with this finding, Alizarin red/Alcian blue staining of 2-day-old Gja1+/- Runx2+/- neonates showed a hypomorphic interparietal bone, an exacerbation of the open fontanelles, and a further reduction in the hypoplastic clavicles compared to Runx2+/- neonates.	alizarin	30-42	runt related transcription factor 2	Mus musculus	85-90
28578888-6	2017	Lastly, SCAP differentiation into a mineralizing phenotype was evaluated in the presence or absence of the tested factors by quantitative alizarin red staining and alkaline phosphatase activity.	alizarin	138-150	SREBF chaperone	Homo sapiens	8-12
28460412-6	2017	Then, both gain- and loss-function experiments, respectively performed by single-strand miR-615-3p mimic and antagomir, revealed that miR-615-3p negatively regulated the osteogenesis of hLF cells, manifested by a lighter staining degree with Alizarin Red and a decreased level of osteogenic marker genes, including alkaline phosphatase (ALP), RUNX2, osterix (ostx), osteocalcin (OCN), and osteopontin (OPN).	alizarin	242-254	microRNA 615	Homo sapiens	134-141
28431147-1	2017	Recently, we have reported that the FLO1-mediated flocculation levels of yeast are affected by an epigenetic mutagen, alizarin.	alizarin	118-126	flocculin FLO1	Saccharomyces cerevisiae S288C	36-40
28431147-9	2017	Moreover, fluorescence intensities of green fluorescent protein (GFP) reporter under the FLO1 promoter control were dose-dependently increased by purprin and alizarin in the yeast.	alizarin	158-166	flocculin FLO1	Saccharomyces cerevisiae S288C	89-93
28386022-4	2017	Using genetically modified mice, we find that integrin-alpha3 (encoded by Itga3), an adhesion receptor at the presynaptic membrane, is involved in the localisation of AZ components and efficient synaptic vesicle release.	alizarin	167-169	integrin alpha 3	Mus musculus	46-61
28342024-8	2017	The results showed that significant higher results demonstrated significant higher adhesive behavior, viability, alizarin red activity, and dentin specific gene expression in MSH- and SIM-treated cells (p &lt; 0.05).	alizarin	113-125	proopiomelanocortin	Homo sapiens	175-178
28386022-4	2017	Using genetically modified mice, we find that integrin-alpha3 (encoded by Itga3), an adhesion receptor at the presynaptic membrane, is involved in the localisation of AZ components and efficient synaptic vesicle release.	alizarin	167-169	integrin alpha 3	Mus musculus	74-79
28135572-10	2017	Additionally, Alizarin red staining showed that the novel mutant DLX3 decreased the mineralization of hDPCs compared with wild-type DLX3.	alizarin	14-26	distal-less homeobox 3	Homo sapiens	65-69
28384239-6	2017	Cells stimulated with bone morphogenetic protein-2 expressed osteocalcin, osterix, and alkaline phosphatase mRNA, resulting in production of mineralized matrices, which were detected by von Kossa and alizarin red staining.	alizarin	200-212	bone morphogenetic protein 2	Mus musculus	22-50
27608420-5	2017	Co-stimulation of RAW cells by IL-15 and RANKL significantly increased the gene expression of osteoclast differentiation and osteoclastogenesis markers compared with stimulation by RANKL or IL-15 independently as evaluated by tartrate-resistant acid phosphate-positive cell numbers, the fusion index, a pit formation assay with Alizarin red staining (calcification estimation), and quantitative polymerase chain reaction.	alizarin	328-340	interleukin 15	Mus musculus	31-36
27608420-5	2017	Co-stimulation of RAW cells by IL-15 and RANKL significantly increased the gene expression of osteoclast differentiation and osteoclastogenesis markers compared with stimulation by RANKL or IL-15 independently as evaluated by tartrate-resistant acid phosphate-positive cell numbers, the fusion index, a pit formation assay with Alizarin red staining (calcification estimation), and quantitative polymerase chain reaction.	alizarin	328-340	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	41-46
28074350-8	2017	Alizarin red staining and atomic absorption spectroscopy demonstrated enhanced osteogenic differentiation as evidenced by increased bone matrix production by the BMSCs treated with BMP-9-cmRNA when compared to cells treated with BMP-2-cmRNA.	alizarin	0-12	growth differentiation factor 2	Homo sapiens	181-186
28012106-8	2017	Moreover, alizarin red staining and osteocalcin labelling promoted mineralised matrix production in c-myb-overexpressing cultures, whereas downregulation of c-myb by siRNA reduced mineralised matrix production.	alizarin	10-22	myeloblastosis oncogene	Mus musculus	100-105
28578703-10	2017	Furthermore, PRP decreased mineralization of PDL cells at 14 days post seeding as assessed by alizarin red staining.	alizarin	94-106	complement component 4 binding protein alpha	Homo sapiens	13-16
27038990-4	2017	Similar to primary osteoblastic cells, osteocalcin transcription increased following 1,25-dihydroxyvitamin D3 treatment and the immortalized cells formed a mineralized matrix, as detected by Alizarin Red staining.	alizarin	191-203	bone gamma-carboxyglutamate protein	Homo sapiens	39-50
28241722-5	2017	Using the over expression and inhibition method, the level of Alizarin Red staining, alkaline phosphatase and ossification related genes in miR-563 were analyzed over expressed or inhibited and ossification induced ligament cells.	alizarin	62-74	microRNA 563	Homo sapiens	140-147
28202998-7	2017	All iPSCs formed typical calcified nodules upon GDF-5 induction by Alizarin red staining in comparison to their untreated controls.	alizarin	67-79	growth differentiation factor 5	Homo sapiens	48-53
27727105-4	2017	Proliferation assay, flow cytometry, and alizarin red staining indicated that CKIP-1 silencing significantly inhibited apoptosis, but promoted osteogenic differentiation of cultured BMSCs.	alizarin	41-53	pleckstrin homology domain containing O1	Rattus norvegicus	78-84
27574032-4	2017	Interestingly, Tcf12 endogenous silencing using shRNA lentivirus significantly promoted the differentiation ability of MSCs evaluated by alkaline phosphatase staining, alizarin red staining and expression of osteoblast-specific markers by real-time PCR.	alizarin	168-180	transcription factor 12	Mus musculus	15-20
27856249-10	2017	Moreover, BMP-2-dependent osteoblastogenesis was further enhanced in Ifrd1 knocked-down osteoblasts, as determined by the intensity of Alizarin red stain and marker gene expression.	alizarin	135-147	bone morphogenetic protein 2	Homo sapiens	10-15
27856249-10	2017	Moreover, BMP-2-dependent osteoblastogenesis was further enhanced in Ifrd1 knocked-down osteoblasts, as determined by the intensity of Alizarin red stain and marker gene expression.	alizarin	135-147	interferon related developmental regulator 1	Homo sapiens	69-74
27876618-7	2017	Knockdown of TLR4 by small interfering RNA (siRNA) significantly reduced Ox-LDL-induced calcification, detected by alizarin red staining and calcium content assay.	alizarin	115-127	toll like receptor 4	Homo sapiens	13-17
27870265-5	2017	Antizyme inhibitor binds to AZ with a higher affinity than ODC.	alizarin	28-30	ornithine decarboxylase 1	Homo sapiens	59-62
28473977-4	2017	Transfection with miR-155 decreased alkaline phosphatase (ALP) activity, ALP expression, and the staining intensity of Alizarin Red in MC3T3-E1 cells treated with BMP2, whereas treatment with miR-155 inhibitor promoted BMP2-induced osteoblast differentiation.	alizarin	119-131	microRNA 155	Mus musculus	18-25
28473977-4	2017	Transfection with miR-155 decreased alkaline phosphatase (ALP) activity, ALP expression, and the staining intensity of Alizarin Red in MC3T3-E1 cells treated with BMP2, whereas treatment with miR-155 inhibitor promoted BMP2-induced osteoblast differentiation.	alizarin	119-131	bone morphogenetic protein 2	Mus musculus	163-167
27941031-7	2016	Az stimulates the degradation of ODC and inhibits polyamine uptake.	alizarin	0-2	ornithine decarboxylase 1	Homo sapiens	33-36
27941031-9	2016	Az binds to monomeric ODC subunits to prevent their reassociation into active homodimers and facilitates their ubiquitin-independent degradation by the 26S proteasome.	alizarin	0-2	ornithine decarboxylase 1	Homo sapiens	22-25
27833148-5	2016	Alizarin red staining showed that hsa-let-7c low-expression can significantly promote the mineralization of IGF-1 treated SCAPs, while hsa-let-7c over-expression can decrease the calcium deposition of IGF-1 treated SCAPs.	alizarin	0-12	microRNA let-7c	Homo sapiens	34-44
27573439-8	2016	Alizarin red staining revealed that the IGF-1-treated cells contained a greater number of mineralization nodules and had higher calcium concentrations.	alizarin	0-12	insulin like growth factor 1	Homo sapiens	40-45
27833148-5	2016	Alizarin red staining showed that hsa-let-7c low-expression can significantly promote the mineralization of IGF-1 treated SCAPs, while hsa-let-7c over-expression can decrease the calcium deposition of IGF-1 treated SCAPs.	alizarin	0-12	insulin like growth factor 1	Homo sapiens	108-113
27549112-5	2016	Furthermore, TSA induced the expression of the flocculin-encoding gene FLO1 The anthracene-derived alizarin, a natural madder root dye, has a potential for carcinogenesis promotion; however, the mode of action has not been elucidated.	alizarin	99-107	flocculin FLO1	Saccharomyces cerevisiae S288C	71-75
27549112-8	2016	Similar to TSA, alizarin also upregulated FLO1 mRNA.	alizarin	16-24	flocculin FLO1	Saccharomyces cerevisiae S288C	42-46
26920892-8	2016	Histological analysis of LBH589-treated tumors revealed significant regions of ossification, confirmed by Alizarin Red staining.	alizarin	106-118	LBH regulator of WNT signaling pathway	Homo sapiens	25-28
27586273-5	2016	The results of alizarin red staining indicated that overexpression of miR-590-3p significantly enhanced mineralized deposition.	alizarin	15-27	microRNA 590	Homo sapiens	70-77
29241211-8	2017	Panx3 overexpression promoted osteogenic differentiation of hDPSCs, whereas depletion of Panx3 resulted in a decline of differentiation, evidenced by upregulated expression of mineralization-related markers, increased alkaline phosphatase (ALP) activity, and enhanced ALP and Alizarin red staining.	alizarin	276-288	pannexin 3	Homo sapiens	89-94
27684064-6	2016	A genetically enforced enlargement of AZ scaffolds (four gene-copies of BRP) impaired memory formation in young animals.	alizarin	38-40	bruchpilot	Drosophila melanogaster	72-75
26895007-6	2016	Addition of SFRP5 significantly inhibited HP-induced calcification of VSMCs as determined by Alizarin red staining and calcium content.	alizarin	93-105	secreted frizzled related protein 5	Homo sapiens	12-17
27182630-2	2016	The intermolecular potential between Az and N2, used for the simulations, was determined from MP2/6-31+G* ab initio calculations.	alizarin	37-39	tryptase pseudogene 1	Homo sapiens	94-102
27414398-3	2016	Histopathological examinations showed very little alizarin red staining in the CA1 pyramidal cell layer until day 28 after reperfusion, while prominent alizarin red staining was detected in CA1 dendritic subfields, particularly in the stratum radiatum, by 14 days after reperfusion.	alizarin	152-164	carbonic anhydrase 1	Rattus norvegicus	190-193
27217047-9	2016	However, in patients who were co-administered AZ, the C0 values of tacrolimus were higher in patients with the CYP3A5*3/*3 allele than with the CYP3A5*1 allele (P = 0.034), although daily doses of Tac-QD in patients with CYP3A5*3/*3 were significantly lower than those with the CYP3A5*1 allele (P = 0.041).	alizarin	46-48	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	111-117
27217047-9	2016	However, in patients who were co-administered AZ, the C0 values of tacrolimus were higher in patients with the CYP3A5*3/*3 allele than with the CYP3A5*1 allele (P = 0.034), although daily doses of Tac-QD in patients with CYP3A5*3/*3 were significantly lower than those with the CYP3A5*1 allele (P = 0.041).	alizarin	46-48	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	144-150
27217047-9	2016	However, in patients who were co-administered AZ, the C0 values of tacrolimus were higher in patients with the CYP3A5*3/*3 allele than with the CYP3A5*1 allele (P = 0.034), although daily doses of Tac-QD in patients with CYP3A5*3/*3 were significantly lower than those with the CYP3A5*1 allele (P = 0.041).	alizarin	46-48	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	144-150
27217047-9	2016	However, in patients who were co-administered AZ, the C0 values of tacrolimus were higher in patients with the CYP3A5*3/*3 allele than with the CYP3A5*1 allele (P = 0.034), although daily doses of Tac-QD in patients with CYP3A5*3/*3 were significantly lower than those with the CYP3A5*1 allele (P = 0.041).	alizarin	46-48	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	144-150
27217047-10	2016	The cumulative incidence of acute kidney injury was higher in patients with the CYP3A5*3/*3 than with the CYP3A5*1 allele when AZ was co-administered.	alizarin	127-129	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	80-86
27217047-10	2016	The cumulative incidence of acute kidney injury was higher in patients with the CYP3A5*3/*3 than with the CYP3A5*1 allele when AZ was co-administered.	alizarin	127-129	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	106-112
27217047-12	2016	CONCLUSIONS: CYP3A5 genotyping may be useful for safe and effective immunosuppressive therapy with Tac-QD in HSCT patients in whom the use of AZ is anticipated.	alizarin	142-144	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	13-19
26961489-7	2016	Alizarin Red staining showed that APN promoted h-JBMMSC osteogenesis.	alizarin	0-12	adiponectin, C1Q and collagen domain containing	Homo sapiens	34-37
26927515-8	2016	To translationally validate the positive effects of FRZB on primary human cells, we treated human periosteal and human bone marrow stromal cells with conditioned medium from MC3T3-E1 cells overexpressing Frzb and observed an increase in Alizarin red staining.	alizarin	237-249	frizzled related protein	Homo sapiens	52-56
28247599-8	2016	After 21 days of osteogenic induction, alizarin red staining showed that overexpression of miR-705 significantly reduced the formation of mineralized node, the opposite results were found in miR-705 knockdown group (all P&lt;0.05).	alizarin	39-51	microRNA 705	Mus musculus	91-98
27119764-9	2016	Moreover, the combination of FGF-2 and MEL showed increased osteogenic activity within the IP-CHA construct in terms of cell proliferation, upregulated expressions of OCN and OPN, increased ALP activity and mineralization with Alizarin Red.	alizarin	227-239	fibroblast growth factor 2	Mus musculus	29-34
27117217-8	2016	The alizarin red staining showed that PDLSC in TNF-alpha group generated less mineralized nodule than the control group, while the cell matrix mineralization in TSA group was improved obviously.	alizarin	4-16	tumor necrosis factor	Homo sapiens	47-56
26763602-9	2016	Activation of TLR4 inhibited the mineralization of enamel and dentin, as demonstrated by alizarin red staining and as decreased levels of collagen type X. mRNA expression of ameloblastin was elevated after LPS administration.	alizarin	89-101	toll-like receptor 4	Mus musculus	14-18
26915799-5	2016	Additionally, purified AZ, particularly AZ1, increased the activity of purified ACLY in a dose-dependent manner in vitro, suggesting that AZ activates ACLY through protein-protein interaction.	alizarin	23-25	centrosomal protein 131	Homo sapiens	40-43
26915799-5	2016	Additionally, purified AZ, particularly AZ1, increased the activity of purified ACLY in a dose-dependent manner in vitro, suggesting that AZ activates ACLY through protein-protein interaction.	alizarin	23-25	ATP citrate lyase	Homo sapiens	80-84
26915799-5	2016	Additionally, purified AZ, particularly AZ1, increased the activity of purified ACLY in a dose-dependent manner in vitro, suggesting that AZ activates ACLY through protein-protein interaction.	alizarin	23-25	ATP citrate lyase	Homo sapiens	151-155
26915799-5	2016	Additionally, purified AZ, particularly AZ1, increased the activity of purified ACLY in a dose-dependent manner in vitro, suggesting that AZ activates ACLY through protein-protein interaction.	alizarin	40-42	ATP citrate lyase	Homo sapiens	80-84
26915799-5	2016	Additionally, purified AZ, particularly AZ1, increased the activity of purified ACLY in a dose-dependent manner in vitro, suggesting that AZ activates ACLY through protein-protein interaction.	alizarin	40-42	ATP citrate lyase	Homo sapiens	151-155
27186279-4	2016	Real-time PCR, Western blot, alkaline phosphatase activity assay, and alizarin red staining demonstrated that the overexpression of CTGF enhanced osteogenesis in vitro.	alizarin	70-82	cellular communication network factor 2	Mus musculus	132-136
26315505-8	2016	Furthermore, an immunofluorescence staining assay showed that more MG63 cells were OPN-positive, while an Alizarin red staining indicated the increased formation of calcium nodules in the IFN-gamma and TNF-alpha combined pretreatment group.	alizarin	106-118	interferon gamma	Homo sapiens	188-197
26315505-8	2016	Furthermore, an immunofluorescence staining assay showed that more MG63 cells were OPN-positive, while an Alizarin red staining indicated the increased formation of calcium nodules in the IFN-gamma and TNF-alpha combined pretreatment group.	alizarin	106-118	tumor necrosis factor	Homo sapiens	202-211
26926195-5	2016	The osterix gene expression in tooth development and mineralization was highlighted by alizarin red staining.	alizarin	87-99	Sp7 transcription factor	Danio rerio	4-11
26763602-9	2016	Activation of TLR4 inhibited the mineralization of enamel and dentin, as demonstrated by alizarin red staining and as decreased levels of collagen type X. mRNA expression of ameloblastin was elevated after LPS administration.	alizarin	89-101	ameloblastin	Mus musculus	174-186
25832621-6	2015	However, alkaline phosphatase (ALP) activity measurements, Alizarin red staining and analyses by quantitative real-time reverse transcription with the polymerase chain reaction revealed that leptin upregulated ALP activity, mineral deposition and the mRNA levels of runt-related transcription factor 2, ALP and collagen type I. Lastly, the effects of leptin on osteogenic differentiation were assessed in vivo.	alizarin	59-71	leptin	Homo sapiens	191-197
26449203-5	2015	Moreover, the western blotting of osteogenic differentiation biomarkers, alkaline phosphatase (ALP) staining and Alizarin red staining showed that CRABP2 dramatically inhibited osteogenic differentiation.	alizarin	113-125	cellular retinoic acid binding protein II	Mus musculus	147-153
25728281-4	2015	The results of biochemical studies show that Az binds to Hsc70 and Hsp70 without binding to other types of heat shock proteins.	alizarin	45-47	heat shock protein family A (Hsp70) member 8	Homo sapiens	57-62
25728281-4	2015	The results of biochemical studies show that Az binds to Hsc70 and Hsp70 without binding to other types of heat shock proteins.	alizarin	45-47	heat shock protein family A (Hsp70) member 8	Homo sapiens	67-72
25728281-6	2015	The results obtained from cell experiments reveal that Az disrupts the interaction of Hsc70 with clathrin in cells, thereby leading to the accumulation of transferrin in CCVs and suppression of release of free Fe(3+) from CCVs during transferrin receptor-mediated endocytosis.	alizarin	55-57	heat shock protein family A (Hsp70) member 8	Homo sapiens	86-91
25728281-6	2015	The results obtained from cell experiments reveal that Az disrupts the interaction of Hsc70 with clathrin in cells, thereby leading to the accumulation of transferrin in CCVs and suppression of release of free Fe(3+) from CCVs during transferrin receptor-mediated endocytosis.	alizarin	55-57	transferrin	Homo sapiens	155-166
25728281-6	2015	The results obtained from cell experiments reveal that Az disrupts the interaction of Hsc70 with clathrin in cells, thereby leading to the accumulation of transferrin in CCVs and suppression of release of free Fe(3+) from CCVs during transferrin receptor-mediated endocytosis.	alizarin	55-57	transferrin	Homo sapiens	234-245
26652990-8	2015	Moreover, alizarin red staining verified positive red nodules on calcified VSMCs was significantly reduced in FGF21 group than in calcification group.	alizarin	10-22	fibroblast growth factor 21	Rattus norvegicus	110-115
26172301-5	2015	Our data indicate that CCND1 has a 4-fold lower binding affinity for AZ than does ODC and an approximately 40-fold lower binding affinity for AZ than does AZI.	alizarin	69-71	cyclin D1	Homo sapiens	23-28
26172301-5	2015	Our data indicate that CCND1 has a 4-fold lower binding affinity for AZ than does ODC and an approximately 40-fold lower binding affinity for AZ than does AZI.	alizarin	142-144	cyclin D1	Homo sapiens	23-28
26093026-3	2015	Our previous studies demonstrated that AZ synthesis is stimulated by the absence of amino acids, the levels of which are sensed by the mTOR complex containing TORC1, which is stimulated by amino acids and inhibited by their absence, and TORC2 the function of which is not well defined.	alizarin	39-41	mechanistic target of rapamycin kinase	Homo sapiens	135-139
26093026-3	2015	Our previous studies demonstrated that AZ synthesis is stimulated by the absence of amino acids, the levels of which are sensed by the mTOR complex containing TORC1, which is stimulated by amino acids and inhibited by their absence, and TORC2 the function of which is not well defined.	alizarin	39-41	CREB regulated transcription coactivator 1	Homo sapiens	159-164
26093026-3	2015	Our previous studies demonstrated that AZ synthesis is stimulated by the absence of amino acids, the levels of which are sensed by the mTOR complex containing TORC1, which is stimulated by amino acids and inhibited by their absence, and TORC2 the function of which is not well defined.	alizarin	39-41	CREB regulated transcription coactivator 2	Homo sapiens	237-242
26093026-6	2015	We have demonstrated that mTORC2 activity is necessary for AZ synthesis in the absence of amino acids.	alizarin	59-61	CREB regulated transcription coactivator 2	Mus musculus	26-32
26093026-8	2015	TSC2 knockdown increased mTORC1 activity with concomitant inhibition of mTORC2 activity eliminating AZ induction in the absence of amino acids as well as that induced by spermidine.	alizarin	100-102	TSC complex subunit 2	Homo sapiens	0-4
26093026-8	2015	TSC2 knockdown increased mTORC1 activity with concomitant inhibition of mTORC2 activity eliminating AZ induction in the absence of amino acids as well as that induced by spermidine.	alizarin	100-102	CREB regulated transcription coactivator 2	Mus musculus	72-78
26093026-9	2015	Thus, these results clearly demonstrate that in addition to polyamines, mTORC2 activity is necessary for AZ synthesis.	alizarin	105-107	CREB regulated transcription coactivator 2	Mus musculus	72-78
26285013-5	2015	Deletion of RBPJK in MSCs not only enhances cell spontaneous differentiation, but also significantly accelerates condition media inducted osteogenic differentiation by showing enhanced alkaline phosphatase (ALP) activity, Alizarin red staining, gene expression of Runx2, Osteopontin (OPN), Type I collagen (COL1a1) in culture.	alizarin	222-234	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	12-17
26051078-10	2015	RESULTS: Interferon gamma (FN-gamma) treatment significantly abrogated the differentiation potential of DPSCs as shown by using alizarin red and alkaline phosphatase activity analysis.	alizarin	128-140	interferon gamma	Homo sapiens	9-25
25813938-3	2015	Az reduces the cellular polyamine content by down-regulating both the enzyme catalysing polyamine biosynthesis, ornithine decarboxylase (ODC), and the uptake of polyamines.	alizarin	0-2	ornithine decarboxylase 1	Homo sapiens	112-135
25813938-3	2015	Az reduces the cellular polyamine content by down-regulating both the enzyme catalysing polyamine biosynthesis, ornithine decarboxylase (ODC), and the uptake of polyamines.	alizarin	0-2	ornithine decarboxylase 1	Homo sapiens	137-140
25676585-5	2015	Staining with alizarin red revealed that MC3T3-E1 mineralization was enhanced by overexpression of Fhl1.	alizarin	14-26	four and a half LIM domains 1	Mus musculus	99-103
26380065-5	2015	CD29(+)/CD90(+) cells showed a reduction in both osteogenic and adipogenic differentiation when compared with unsorted cells, as determined by alizarin red and Oil Red-O staining, respectively.	alizarin	143-155	Thy-1 cell surface antigen	Rattus norvegicus	8-12
27607236-11	2016	The results of alizarin red staining and ALP detection showed that SpA treatment suppressed the osteogenic differentiation of hBMSCs.	alizarin	15-27	surfactant protein A1	Homo sapiens	67-70
26689714-9	2015	Moreover, alizarin red staining quantification, ALP quantification and calcein blue fluorescence showed the osteogenic potential of BMSCs treated with PRP and calcium phosphate particles The implanted BMSCs were detectable at 1 day, 3 days, 7 days, 2 weeks and 4 weeks after surgery by a small animal in vivo fluorescence imaging system and were visualized in the defect zones by confocal microscopy.	alizarin	10-22	proline rich protein 2-like 1	Rattus norvegicus	151-154
26779524-7	2015	RESULTS: Extent of tissue valve calcification (Alizarin Red stain) was negatively correlated with tissue elastin, and RL2, and positively correlated with tissue OCN and serum TIMP1 and MCP-1 and negatively with MMP9.	alizarin	47-59	elastin	Homo sapiens	105-112
26779524-7	2015	RESULTS: Extent of tissue valve calcification (Alizarin Red stain) was negatively correlated with tissue elastin, and RL2, and positively correlated with tissue OCN and serum TIMP1 and MCP-1 and negatively with MMP9.	alizarin	47-59	relaxin 2	Homo sapiens	118-121
26779524-7	2015	RESULTS: Extent of tissue valve calcification (Alizarin Red stain) was negatively correlated with tissue elastin, and RL2, and positively correlated with tissue OCN and serum TIMP1 and MCP-1 and negatively with MMP9.	alizarin	47-59	bone gamma-carboxyglutamate protein	Homo sapiens	161-164
26779524-7	2015	RESULTS: Extent of tissue valve calcification (Alizarin Red stain) was negatively correlated with tissue elastin, and RL2, and positively correlated with tissue OCN and serum TIMP1 and MCP-1 and negatively with MMP9.	alizarin	47-59	matrix metallopeptidase 9	Homo sapiens	211-215
26374253-9	2015	Alizarin red staining was positive in all samples at day 28 and significant increases in alkaline phosphatase (p &lt; 0.001) and osteocalcin (p &lt; 0.05) gene expression were also observed compared with day 0.	alizarin	0-12	bone gamma-carboxyglutamate protein	Homo sapiens	129-140
26552234-6	2015	The relationship of the cx43 gene expression and anatomy of the pharyngeal teeth were compared by alizarin red staining.	alizarin	98-110	gap junction protein alpha 1b	Danio rerio	24-28
25667190-12	2015	Mineralization in response to BMP-2 was evaluated by alizarin red staining.	alizarin	53-65	bone morphogenetic protein 2	Homo sapiens	30-35
26136955-11	2015	Enhanced ALP activity and Alizarin red staining were observed in the MC3T3-E1-DLX2 cells when compared with the control group.	alizarin	26-38	distal-less homeobox 2	Mus musculus	78-82
24797761-4	2015	Cells grown on FA and treated with VEGF demonstrated osteogenic differentiation as measured with ALP staining, and obvious mineralization as measured by Alizarin red staining.	alizarin	153-165	vascular endothelial growth factor A	Homo sapiens	35-39
25870110-5	2015	Newborn CypA-deficient pups double stained with alcian blue and alizarin red exhibited generalized, pronounced skeletal defects, while high-resolution micro-computed tomography (microCT) analyses of the femurs and lumbar vertebrae revealed delayed or incomplete endochondral ossification.	alizarin	64-76	peptidylprolyl isomerase A	Mus musculus	8-12
25893559-5	2015	The supramolecular polymer CDR/Az-I-Dex with high a C/A molar ratio (molar ratio of CD on CDR to Az on Az-I-Dex) was unfavorable for DNA condensation.	alizarin	31-33	ornithine decarboxylase antizyme 1	Homo sapiens	103-107
25805267-8	2015	After osteogenesis, P5, P10, P15 and P21 MDSCs formed Alizarin red- and osteocalcin-positive bone nodules.	alizarin	54-66	cyclin-dependent kinase inhibitor 2B	Rattus norvegicus	29-32
25805267-8	2015	After osteogenesis, P5, P10, P15 and P21 MDSCs formed Alizarin red- and osteocalcin-positive bone nodules.	alizarin	54-66	KRAS proto-oncogene, GTPase	Rattus norvegicus	37-40
25714841-8	2015	Alkaline phosphatase (ALP) staining and activity assays, as well as Alizarin red staining demonstrated that osteoblast attachment to CTGF matrix enhanced maturation, bone nodule formation and matrix mineralization.	alizarin	68-80	cellular communication network factor 2	Mus musculus	133-137
24797761-6	2015	VEGF signaling pathway perturbation using a specific VEGF receptor inhibitor showed the lowest levels of ALP and Alizarin red staining, which was partially rescued when the cells were grown on FA and/or treated with the addition of VEGF.	alizarin	113-125	vascular endothelial growth factor A	Homo sapiens	0-4
24797761-6	2015	VEGF signaling pathway perturbation using a specific VEGF receptor inhibitor showed the lowest levels of ALP and Alizarin red staining, which was partially rescued when the cells were grown on FA and/or treated with the addition of VEGF.	alizarin	113-125	vascular endothelial growth factor A	Homo sapiens	53-57
24797761-6	2015	VEGF signaling pathway perturbation using a specific VEGF receptor inhibitor showed the lowest levels of ALP and Alizarin red staining, which was partially rescued when the cells were grown on FA and/or treated with the addition of VEGF.	alizarin	113-125	vascular endothelial growth factor A	Homo sapiens	53-57
25613605-4	2015	The effect of Dkk1, a WNT signaling inhibitor, on high glucose-induced cell calcification was tested with alizarin red staining and calcium content analysis.	alizarin	106-118	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	14-18
25480698-7	2015	However, alizarin staining denoted a markedly lower calcification level in the cells from the NF1-diagnosed child, considering that less calcium deposits were visualized under light microscopy and a smaller amount of alizarin could be quantified by spectrophotometry after extraction from the stained cells.	alizarin	9-17	neurofibromin 1	Homo sapiens	94-97
25480698-7	2015	However, alizarin staining denoted a markedly lower calcification level in the cells from the NF1-diagnosed child, considering that less calcium deposits were visualized under light microscopy and a smaller amount of alizarin could be quantified by spectrophotometry after extraction from the stained cells.	alizarin	217-225	neurofibromin 1	Homo sapiens	94-97
26125268-10	2015	Alizarin Red staining revealed that more calcified nodules were formed in BMP-2 transfected ADSCs.	alizarin	0-12	bone morphogenetic protein 2	Mus musculus	74-79
25201465-3	2014	Alizarin red staining of skulls from Fbln1-deficient mice showed reduced mineralization of both membranous and endochondral bones.	alizarin	0-12	fibulin 1	Mus musculus	37-42
24265122-9	2014	C2C12 myoblasts overexpressing OA showed an increase in expression of bone specific markers such as alkaline phosphatase and alizarin red staining, and also showed an increase in Runx2 protein expression.	alizarin	125-137	glycoprotein nmb	Homo sapiens	31-33
24839202-3	2014	MC-3T3 preosteoblasts expressed IGFBP-2, and IGFBP-2 knockdown resulted in a substantial delay in osteoblast differentiation, reduced osteocalcin expression and Alizarin red staining.	alizarin	161-173	insulin-like growth factor binding protein 2	Mus musculus	45-52
24854876-7	2014	RESULTS: Increased osteogenic differentiation was noted in the BMPR-IB(+) subpopulation, as demonstrated by alkaline phosphatase staining at day 7 and extracellular matrix mineralization with Alizarin red staining at day 14.	alizarin	192-204	bone morphogenetic protein receptor type 1B	Homo sapiens	63-70
25329544-8	2014	Furthermore, we demonstrate enhanced in vitro osteogenic differentiation of preosteoblasts cultured on Fn-Tigra over those cultured on bare Ti, as determined via Alizarin red and von Kossa staining, and the analysis of osteocalcin, type I collagen, alkaline phosphatase activity, and calcium contents.	alizarin	162-174	fibronectin 1	Homo sapiens	103-105
24907519-9	2014	RESULTS: The presence of IL-17 significantly reduced alkaline phosphatase and alizarin red staining and the expression of alkaline phosphatase, osteocalcin, and osterix in vitro.	alizarin	78-90	interleukin 17A	Rattus norvegicus	25-30
25086868-6	2014	RESULTS: PRP enhanced UC-MSC proliferation, and 10% PRP caused the strongest ALP and Alizarin red staining.	alizarin	85-97	proline rich protein 2-like 1	Rattus norvegicus	52-55
24138099-12	2014	When stained with alizarin red, cells overexpressing FDC-SP formed less mineralized nodules at 21 d post-induction of differentiation, compared with the control cultures.	alizarin	18-30	follicular dendritic cell secreted protein	Homo sapiens	53-59
23738684-10	2014	However, the expression of BSP and RUNX2 genes was higher at 7 d compared to 3 d. Significant calcium mineralization was detected as quantified by alizarin red assay at 14 d in 1 : 1 (1323.55 +- 6.54 mum) and 5 : 1 (994.67 +- 4.15 mum) co-cultures as compared with monoculture cell sheets (p &lt; 0.05).	alizarin	147-159	integrin binding sialoprotein	Homo sapiens	27-30
23738684-10	2014	However, the expression of BSP and RUNX2 genes was higher at 7 d compared to 3 d. Significant calcium mineralization was detected as quantified by alizarin red assay at 14 d in 1 : 1 (1323.55 +- 6.54 mum) and 5 : 1 (994.67 +- 4.15 mum) co-cultures as compared with monoculture cell sheets (p &lt; 0.05).	alizarin	147-159	RUNX family transcription factor 2	Homo sapiens	35-40
25610471-11	2014	The intensity of alizarin red and ALP staining was strongest in the TLR-3 activated group and weakest in the TLR-4 activated group.	alizarin	17-29	toll like receptor 3	Homo sapiens	68-73
24712305-9	2014	Collagen II deposits and alizarin red staining for bone were found in 6 hMSC- and 2 saline-treated tendons 6 weeks after injury.	alizarin	25-37	musculin	Homo sapiens	72-83
23662917-9	2014	RESULTS: The expression of RUNX2 demonstrated successful osteogenic induction of all cell types, which was confirmed by alizarin red stain.	alizarin	120-132	RUNX family transcription factor 2	Homo sapiens	27-32
24520257-6	2014	The results of alizarin red and alkaline phosphatase (ALP) staining at 14 days subsequent to transfection showed that the area of staining in cells transfected with BMP2 alone was higher than that in cells transfected with BMP2 and VEGF165 or untransfected control cells, while the BMP2 + VEGF165 group showed significantly more staining than the untransfected control.	alizarin	15-27	bone morphogenetic protein 2	Rattus norvegicus	165-169
25610471-11	2014	The intensity of alizarin red and ALP staining was strongest in the TLR-3 activated group and weakest in the TLR-4 activated group.	alizarin	17-29	toll like receptor 4	Homo sapiens	109-114
24386225-9	2013	Finally, miR-720 decreased DPC proliferation as determined by immunocytochemical analysis against ki-67, and promoted odontogenic differentiation as demonstrated by alizarin red staining, as well as alkaline phosphatase and osteopontin mRNA levels.	alizarin	165-177	membrane associated ring-CH-type finger 8	Homo sapiens	9-12
23954814-9	2013	Alizarin positive reaction, large amount of calcium quantification, and greater alkaline phosphatase activity were shown in both the non-cryopreserved and CAS groups after osteogenic differentiation.	alizarin	0-8	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	155-158
24158144-5	2013	Using shRNA-expressing lentivirus, we performed KDM6B knockdown in dental MSCs and observed that KDM6B depletion leads to a significant reduction in alkaline phosphate (ALP) activity and in formation of mineralized nodules assessed by Alizarin Red staining.	alizarin	235-247	lysine demethylase 6B	Homo sapiens	97-102
24343085-3	2013	RESULTS: For the 21 days, alizarin red staining icariin group formed more mineralized nodules; on the 2nd, 4th, and 6th days, the group of icariin promoted the expression of ALP and OC mRNA, reached the peak value on day 6, compared with the control group with significant difference (20.15+-6.67 vs. 7.90+-0.71, 4.13+-0.56 vs. 3.55+-0.08, P&lt;0.01).	alizarin	26-38	alkaline phosphatase, placental	Homo sapiens	174-177
24343085-3	2013	RESULTS: For the 21 days, alizarin red staining icariin group formed more mineralized nodules; on the 2nd, 4th, and 6th days, the group of icariin promoted the expression of ALP and OC mRNA, reached the peak value on day 6, compared with the control group with significant difference (20.15+-6.67 vs. 7.90+-0.71, 4.13+-0.56 vs. 3.55+-0.08, P&lt;0.01).	alizarin	26-38	bone gamma-carboxyglutamate protein	Homo sapiens	182-184
23499826-4	2013	BMP-4-induced mineralization shown by Alizarin red staining was also facilitated by estrogen treatment.	alizarin	38-50	bone morphogenetic protein 4	Mus musculus	0-5
23553732-6	2013	Bone marrow stromal cells (BMSCs) from Wwp1(-/-) mice formed increased numbers and areas of alkaline phosphatase(+) and Alizarin red(+) nodules and had increased migration potential toward chemokine (C-X-C motif) ligand 12 (CXCL12) gradients.	alizarin	120-132	WW domain containing E3 ubiquitin protein ligase 1	Mus musculus	39-43
23261253-4	2013	METHODS: The differentiation of dNC-PCs and SHED under in vitro conditions was verified by Alizarin red staining (mineralisation), alkaline phosphatase activity and the expression of osteogenic/odontogenic markers (RT-PCRs).	alizarin	91-103	dunce	Drosophila melanogaster	32-35
23675479-7	2013	In vitro differentiation was impaired in both Lrp5 and Lrp6 null osteoblasts as indexed by alkaline phosphatase and Alizarin red staining, but the defect was more pronounced in Lrp6 mutant cells.	alizarin	116-128	low density lipoprotein receptor-related protein 6	Mus musculus	55-59
23939834-6	2013	hMSCs incubated in osteogenic medium in presence of PEDF deposited 50% more mineral (2.108 +- 0.306 OD/ml per well per 1 x 10(4) cells per square centimeter, p = .017) than MSCs incubated in absence of the protein (1.398 +- 0.098 OD/ml per well per 1 x 10(4) cells per square centimeter) as determined by Alizarin Red quantitation.	alizarin	305-317	serpin family F member 1	Homo sapiens	52-56
24088802-8	2013	These findings were corroborated by stainings for ALP and alizarin red that demonstrated a more active osteogenesis in the SCD1 overexpressing cells 2 weeks after osteogenic induction.	alizarin	58-70	stearoyl-CoA desaturase	Homo sapiens	123-127
23924189-9	2013	Alizarin red staining and RT-PCR for alkaline phosphatase demonstrated that elevated BMI resulted in compromised ASC mineralization of extracellular matrix and decreased alkaline phosphatase mRNA expression.	alizarin	0-12	PYD and CARD domain containing	Homo sapiens	113-116
23702148-5	2013	In vitro studies showed that PTHrP treatment significantly reduced Alizarin Red staining and expression of terminal differentiation-related markers.	alizarin	67-79	parathyroid hormone-related protein	Oryctolagus cuniculus	29-34
23413146-6	2013	In vitro, osteoblasts from Pedf null mice exhibited enhanced mineral deposition as assessed by Alizarin Red staining and an increased mineral:matrix determined by FTIR analysis of calcified nodules.	alizarin	95-107	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	27-31
23661017-7	2013	Nanog knock down revealed a significant increase in osteogenic markers, Osteocalcin and Osteopontin expression as well as a positive Alizarin Red staining, which proposes Osteogenesis.	alizarin	133-145	Nanog homeobox	Homo sapiens	0-5
23624039-3	2013	A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 530 nm of (Br-HCl)with PA, CLPH, AR and Rk respectively; 410, 410, 435 and 530 of (E-HCl) with PA, CLPH, AR and Rk respectively.	alizarin	189-191	calcium binding protein, spermatid associated 1	Homo sapiens	255-259
23624039-3	2013	A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 530 nm of (Br-HCl)with PA, CLPH, AR and Rk respectively; 410, 410, 435 and 530 of (E-HCl) with PA, CLPH, AR and Rk respectively.	alizarin	261-263	calcium binding protein, spermatid associated 1	Homo sapiens	183-187
23624039-3	2013	A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 530 nm of (Br-HCl)with PA, CLPH, AR and Rk respectively; 410, 410, 435 and 530 of (E-HCl) with PA, CLPH, AR and Rk respectively.	alizarin	261-263	calcium binding protein, spermatid associated 1	Homo sapiens	255-259
22949393-11	2013	When stained with Alizarin Red, cells overexpressing RAMP1 were darker and formed many mineralised nodules with clear boundaries and calcium deposition typical of mineralised bone matrix structures at 28 days post-induction of differentiation.	alizarin	18-30	receptor activity modifying protein 1	Homo sapiens	53-58
22669486-8	2013	BMP2 also increased mineralization of primary osteoblasts as demonstrated by alizarin red staining when compared to control and TGFbeta1 soak-loaded membranes.	alizarin	77-89	bone morphogenetic protein 2	Homo sapiens	0-4
23216074-13	2013	Staining at day 14 for alizarin red demonstrated the greatest amount of mineralized extracellular matrix in the CD90(+) cells, again followed by the CD105(low) cells.	alizarin	23-35	Thy-1 cell surface antigen	Homo sapiens	112-116
23222816-5	2013	AZ expression also reduced progression to carcinoma in situ or invasive carcinoma and decreased expression of the squamous cell carcinoma biomarkers K14, cyclooxygenase-2 and metallothionein.	alizarin	0-2	keratin 14	Mus musculus	149-152
23222816-5	2013	AZ expression also reduced progression to carcinoma in situ or invasive carcinoma and decreased expression of the squamous cell carcinoma biomarkers K14, cyclooxygenase-2 and metallothionein.	alizarin	0-2	prostaglandin-endoperoxide synthase 2	Mus musculus	154-170
23262291-3	2013	Overexpression of miR-181a led to upregulation of key markers of osteoblastic differentiation as well as enhanced ALP levels and Alizarin red staining, indicating the importance of this miRNA for osteoblastic differentiation.	alizarin	129-141	microRNA 181a-2	Mus musculus	18-26
24434422-4	2013	MATERIALS AND METHODS: First, the osteoinductive effect of E-BMP-2 was confirmed in vitro in mouse bone marrow stromal cells by analysis of osteocalcin mRNA levels, and calcium deposition was detected by alizarin red staining.	alizarin	204-216	bone morphogenetic protein 2	Homo sapiens	61-66
22327831-5	2012	Following stimulation with bone morphogenetic protein-2, Thy-1(high) cells in vitro showed accelerated induction of ALP activity and formation of alizarin red-positive mineralized matrix compared with Thy-1(low) cells.	alizarin	146-158	bone morphogenetic protein 2	Rattus norvegicus	27-55
23418963-9	2013	Functional overexpression analyses using microRNA mimics revealed that miR-26a/b, as well as miR-29b strongly accelerated osteogenic differentiation of USSC as assessed by Alizarin-Red staining and calcium-release assays.	alizarin	172-184	microRNA 26a-1	Homo sapiens	71-80
23418963-9	2013	Functional overexpression analyses using microRNA mimics revealed that miR-26a/b, as well as miR-29b strongly accelerated osteogenic differentiation of USSC as assessed by Alizarin-Red staining and calcium-release assays.	alizarin	172-184	microRNA 29b-1	Homo sapiens	93-100
22233500-7	2012	After osteogenic induction, cells expressed Osteocalcin, with Alizarin Red and ALP (alkaline phosphatase) staining results both being positive.	alizarin	62-74	osteocalcin	Ovis aries	44-55
22339084-8	2012	Mineralized nodule formation of adiponectin-treated HPDL cells was revealed by Alizarin Red staining.	alizarin	79-91	adiponectin, C1Q and collagen domain containing	Homo sapiens	32-43
22264144-5	2012	We observed that both recombinant SHH-N and NELL-1 protein significantly enhanced osteogenic differentiation and reduced adipose differentiation across all markers examined (alkaline phosphatase, Alizarin red and Oil red O staining, and osteogenic gene expression).	alizarin	196-208	sonic hedgehog signaling molecule	Homo sapiens	34-39
22264144-5	2012	We observed that both recombinant SHH-N and NELL-1 protein significantly enhanced osteogenic differentiation and reduced adipose differentiation across all markers examined (alkaline phosphatase, Alizarin red and Oil red O staining, and osteogenic gene expression).	alizarin	196-208	neural EGFL like 1	Homo sapiens	44-50
22327831-5	2012	Following stimulation with bone morphogenetic protein-2, Thy-1(high) cells in vitro showed accelerated induction of ALP activity and formation of alizarin red-positive mineralized matrix compared with Thy-1(low) cells.	alizarin	146-158	Thy-1 cell surface antigen	Rattus norvegicus	57-62
22493443-6	2012	The results of alkaline phosphatase, Alizarin Red staining, and osteocalcin production assay showed that COUP-TFII overexpression blocks BMP2-induced osteoblast differentiation.	alizarin	37-49	nuclear receptor subfamily 2 group F member 2	Gallus gallus	105-114
22087764-3	2012	Significant co-localization of the OPN protein and calcium deposits in the ischemic core were observed by combining alizarin red staining and OPN immunohistochemistry.	alizarin	116-128	secreted phosphoprotein 1	Rattus norvegicus	35-38
22288815-6	2012	Real-time PCR analysis found that Wnt/beta-catenin strongly upregulated expression of dentine sialophosphoprotein, osteocalcin and ALP in SCAP after incubation with mineralization induction medium, while ALP and alizarin red staining indicated that Wnt/beta-catenin enhanced ALP activity and formation of mineralized nodules.	alizarin	212-224	catenin beta 1	Homo sapiens	38-50
22078764-13	2012	FAp discs stained positively with Alizarin Red and calcium-rich mineralized granules associated with fibrils were observed by SEM at day 35.	alizarin	34-46	fibroblast activation protein alpha	Homo sapiens	0-3
22102412-10	2012	ALP and Alizarin red staining results confirmed that BMP2-induced matrix mineralization was also dependent on ATF6 in vitro.	alizarin	8-20	bone morphogenetic protein 2	Mus musculus	53-57
22174254-3	2011	We discovered that Drosophila Rab3-interacting molecule (RIM)-binding protein (DRBP) is essential not only for the integrity of the AZ scaffold but also for exocytotic neurotransmitter release.	alizarin	132-134	RIM-binding protein	Drosophila melanogaster	30-77
22778550-3	2012	Based on the results of DNA assay, alkaline phosphatase (ALP) activity, alizarin red staining and osteogenic marker genes expression analysis, the BMP2 and BMP7 genes cotransfection group exhibited a higher degree of osteogenic differentiation in vitro.	alizarin	72-84	bone morphogenetic protein 2	Rattus norvegicus	147-151
22112837-5	2012	At the molecular level, AQ and AZ formed DNA adducts, generated free radicals, and upregulated pro-apoptotic signaling molecules (p53, caspases, PARP, death effectors).	alizarin	31-33	tumor protein p53	Homo sapiens	130-133
22112837-5	2012	At the molecular level, AQ and AZ formed DNA adducts, generated free radicals, and upregulated pro-apoptotic signaling molecules (p53, caspases, PARP, death effectors).	alizarin	31-33	poly(ADP-ribose) polymerase 1	Homo sapiens	145-149
22174254-3	2011	We discovered that Drosophila Rab3-interacting molecule (RIM)-binding protein (DRBP) is essential not only for the integrity of the AZ scaffold but also for exocytotic neurotransmitter release.	alizarin	132-134	RIM-binding protein	Drosophila melanogaster	79-83
21920521-4	2011	Adenoviral-mediated over-expression of HGF (AdHGF) in VSMCs accelerated mineralisation, shown by alizarin red staining, and significantly increased (45)Calcium incorporation (1.96 +- 0.54-fold [P &lt; 0.05]) and alkaline phosphatase (ALP) activity (3.01 +- 0.8-fold [P &lt; 0.05]) compared to controls.	alizarin	97-109	hepatocyte growth factor	Homo sapiens	39-42
22455123-6	2012	Osteogeneic differentiation of these CD117 positive stem cells was confirmed by Alizarin Red staining.	alizarin	80-92	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	37-42
21641578-5	2011	RESULTS: TGF-beta1 increased the mineralization and ALP activity of dental pulp cells as revealed by Alizarin red staining and ALP activity assay.	alizarin	101-113	transforming growth factor beta 1	Homo sapiens	9-18
21745208-5	2011	MATERIAL AND METHODS: Expression of SIRT1 and osteoblastic differentiation markers was assessed by RT-PCR, real-time PCR, Alizarin red staining and western blotting.	alizarin	122-134	sirtuin 1	Homo sapiens	36-41
21979385-6	2011	Alizarine-red staining and quantification of ossified bone structures showed that PCB-77 produced concentration-dependent increases in the rate of osteogenic tissue formation.	alizarin	0-13	pyruvate carboxylase	Homo sapiens	82-85
22026161-6	2011	YQHYRJ and the sub-compounds reduced the increase of fibroblast proliferation, mineralization, type I collagen secretion induced by BMP-2 via MTT, alizarin red staining and immunochemical examination.	alizarin	147-159	bone morphogenetic protein 2	Mus musculus	132-137
21174497-9	2011	However, ZHX3 siRNAs suppressed Osterix, but not RUNX2 mRNA expression, within 1 h of osteogenic differentiation, and this suppression was sustained for at least 24 h. The 2 ZHX3 siRNAs also suppressed alkaline phosphatase induction and matrix mineralization (assessed using alizarin red staining), and, further, suppressed the calcium content of the cultures at a later stage of differentiation (days 6-21).	alizarin	275-287	zinc fingers and homeoboxes 3	Homo sapiens	9-13
21732486-6	2011	Our results suggest that VEGFA improves osteogenic differentiation in vitro as indicated by alkaline phosphatase activity, alizarin red staining, and quantitative real-time polymerase chain reaction analysis.	alizarin	123-135	vascular endothelial growth factor A	Homo sapiens	25-30
21552531-1	2011	Both ornithine decarboxylase (ODC) and its regulatory protein, antizyme inhibitor (AZI), can bind with antizyme (AZ), but the latter has a higher AZ-binding affinity.	alizarin	83-85	ornithine decarboxylase 1	Homo sapiens	5-28
21552531-1	2011	Both ornithine decarboxylase (ODC) and its regulatory protein, antizyme inhibitor (AZI), can bind with antizyme (AZ), but the latter has a higher AZ-binding affinity.	alizarin	83-85	ornithine decarboxylase 1	Homo sapiens	30-33
21552531-1	2011	Both ornithine decarboxylase (ODC) and its regulatory protein, antizyme inhibitor (AZI), can bind with antizyme (AZ), but the latter has a higher AZ-binding affinity.	alizarin	83-85	antizyme inhibitor 1	Homo sapiens	63-81
21552531-5	2011	Furthermore, the activity of the AZ-inhibited ODC_N125K/M140K enzyme was hardly rescued by AZI.	alizarin	33-35	ornithine decarboxylase 1	Homo sapiens	46-49
21552531-5	2011	Furthermore, the activity of the AZ-inhibited ODC_N125K/M140K enzyme was hardly rescued by AZI.	alizarin	33-35	antizyme inhibitor 1	Homo sapiens	91-94
21359818-8	2011	Cultures treated with FGF2 followed by FGF9 showed an increased amount of extracted Alizarin red indicating greater osteogenic differentiation.	alizarin	84-96	fibroblast growth factor 2	Mus musculus	22-26
21359818-8	2011	Cultures treated with FGF2 followed by FGF9 showed an increased amount of extracted Alizarin red indicating greater osteogenic differentiation.	alizarin	84-96	fibroblast growth factor 9	Mus musculus	39-43
21575435-8	2011	On the 14th day after osteogenic induction, ALP activity of hASC in the knockdown group [(299.2 +- 22.7), (224.3 +- 17.7) U/g] was much stronger than that in the control group [(129.9 +- 12.9) U/g, P &lt; 0.05] and the same result was achieved for the ALP staining and alizarin red staining.	alizarin	269-281	alkaline phosphatase, placental	Homo sapiens	44-47
21575435-8	2011	On the 14th day after osteogenic induction, ALP activity of hASC in the knockdown group [(299.2 +- 22.7), (224.3 +- 17.7) U/g] was much stronger than that in the control group [(129.9 +- 12.9) U/g, P &lt; 0.05] and the same result was achieved for the ALP staining and alizarin red staining.	alizarin	269-281	PYD and CARD domain containing	Homo sapiens	60-64
21112139-1	2011	Alizarin Red S (ARS), is a water-soluble, widely used anthraquinone dye synthesized by sulfonation of alizarin.	alizarin	102-110	secreted LY6/PLAUR domain containing 1	Homo sapiens	16-19
21295540-2	2011	Despite many studies on the interaction of AZ and ODC, the ODC:AZ complex has not been purified from any source and thus clear information about the stoichiometry of the complex is still lacking.	alizarin	63-65	ornithine decarboxylase 1	Homo sapiens	59-62
21295540-8	2011	The molecular weight of the complex is 90 kDa, which indicates a one to one stoichiometric binding of AZ and ODC in vitro.	alizarin	102-104	ornithine decarboxylase 1	Homo sapiens	109-112
21295540-9	2011	Comparison of the circular dichroism (CD) spectra of the two individual proteins and of the ODC:AZ complex shows a change in the secondary structure in the complex.	alizarin	96-98	ornithine decarboxylase 1	Homo sapiens	92-95
22073206-7	2011	The septuple mutant protein was much less sensitive to AZ inhibition compared to the WT protein, suggesting that these amino acid residues play a role in human ODC-AZ binding.	alizarin	55-57	ornithine decarboxylase antizyme 1	Homo sapiens	160-166
21233565-0	2011	Interaction between alizarin and human serum albumin by fluorescence spectroscopy.	alizarin	20-28	albumin	Homo sapiens	39-52
21233565-1	2011	The binding properties on alizarin to human serum albumin (HSA) have been studied for the first time using fluorescence spectroscopy in combination with UV-visible absorbance spectroscopy.	alizarin	26-34	albumin	Homo sapiens	44-57
21233565-1	2011	The binding properties on alizarin to human serum albumin (HSA) have been studied for the first time using fluorescence spectroscopy in combination with UV-visible absorbance spectroscopy.	alizarin	26-34	albumin	Homo sapiens	59-62
21233565-2	2011	The results showed that alizarin strongly quenched the intrinsic fluorescence of HSA through a static quenching procedure, and non-radiation energy transfer occurred within the molecules.	alizarin	24-32	albumin	Homo sapiens	81-84
21233565-6	2011	In addition, the results obtained from synchronous fluorescence spectra and three-dimensional fluorescence spectra showed that the binding of alizarin with HSA could induce conformational changes in HSA.	alizarin	142-150	albumin	Homo sapiens	156-159
21233565-6	2011	In addition, the results obtained from synchronous fluorescence spectra and three-dimensional fluorescence spectra showed that the binding of alizarin with HSA could induce conformational changes in HSA.	alizarin	142-150	albumin	Homo sapiens	199-202
21318879-5	2011	Az inactivates Ornithine decarboxylase [(ODC), the first key enzyme in the polyamine biosynthetic pathway] and marks it for ubiquitin-independent degradation by the 26S proteasome.	alizarin	0-2	ornithine decarboxylase 1	Homo sapiens	15-38
21318879-5	2011	Az inactivates Ornithine decarboxylase [(ODC), the first key enzyme in the polyamine biosynthetic pathway] and marks it for ubiquitin-independent degradation by the 26S proteasome.	alizarin	0-2	ornithine decarboxylase 1	Homo sapiens	41-44
22073206-13	2011	These affinities are 6-fold higher than the WT_ODC K(d), which suggests that residues 119 and 137 play a role in AZ binding.	alizarin	113-115	ornithine decarboxylase 1	Homo sapiens	47-50
20843786-9	2010	Sh-Pdia3 cells produced higher numbers of von Kossa-positive nodules and alizarin red-positive nodules compared with WT cells with or without 1,25(OH)(2)D(3) treatment whereas Ov-Pdia3 did not show any mineralization.	alizarin	73-85	protein disulfide isomerase associated 3	Mus musculus	3-8
21931692-2	2011	Antizyme inhibitor (AZI) is homologous to ODC, but has a higher affinity than ODC for AZ.	alizarin	20-22	antizyme inhibitor 1	Homo sapiens	0-18
21931692-2	2011	Antizyme inhibitor (AZI) is homologous to ODC, but has a higher affinity than ODC for AZ.	alizarin	20-22	ornithine decarboxylase 1	Homo sapiens	42-45
21931692-2	2011	Antizyme inhibitor (AZI) is homologous to ODC, but has a higher affinity than ODC for AZ.	alizarin	20-22	ornithine decarboxylase 1	Homo sapiens	78-81
21931692-3	2011	In this study, we quantified the biomolecular interactions between AZ and ODC as well as AZ and AZI to identify functional AZ peptides that could bind to ODC and AZI and inhibit their function as efficiently as the full-length AZ protein.	alizarin	67-69	ornithine decarboxylase 1	Homo sapiens	154-157
21931692-3	2011	In this study, we quantified the biomolecular interactions between AZ and ODC as well as AZ and AZI to identify functional AZ peptides that could bind to ODC and AZI and inhibit their function as efficiently as the full-length AZ protein.	alizarin	67-69	antizyme inhibitor 1	Homo sapiens	162-165
21931692-3	2011	In this study, we quantified the biomolecular interactions between AZ and ODC as well as AZ and AZI to identify functional AZ peptides that could bind to ODC and AZI and inhibit their function as efficiently as the full-length AZ protein.	alizarin	89-91	ornithine decarboxylase 1	Homo sapiens	154-157
20413153-7	2010	RT-PCR analysis and alizarin red staining revealed a high expression of osteogenesis-related markers (osteopontin, osteocalcin and collagen type I) and increased mineralization in BMP2/Runx2-ASCs compared to BMP2-ASCs.	alizarin	20-32	bone morphogenetic protein 2	Homo sapiens	180-184
20595654-6	2010	RANKL also induced bone-related gene mRNA expression and calcium deposition (Alizarin red staining) followed by the osteogenic differentiation of HASMCs.	alizarin	77-89	TNF superfamily member 11	Homo sapiens	0-5
20509757-7	2010	The rate of mineralization, assessed by von Kossa and Alizarin Red staining, was clearly enhanced in hOBs stimulated by IL-4 or IL-13.	alizarin	54-66	interleukin 4	Homo sapiens	120-124
20509757-7	2010	The rate of mineralization, assessed by von Kossa and Alizarin Red staining, was clearly enhanced in hOBs stimulated by IL-4 or IL-13.	alizarin	54-66	interleukin 13	Homo sapiens	128-133
20413153-7	2010	RT-PCR analysis and alizarin red staining revealed a high expression of osteogenesis-related markers (osteopontin, osteocalcin and collagen type I) and increased mineralization in BMP2/Runx2-ASCs compared to BMP2-ASCs.	alizarin	20-32	RUNX family transcription factor 2	Homo sapiens	185-190
20234301-6	2010	The reduction of high-sensitive C-reactive protein (mg/L) and serum asymmetric dimethylarginine (micromol/L) was significantly greater in the AZ group than in the TCM group (between-group difference was 0.18 and 0.05; 95%CI: -0.01 to 0.36 and -0.01 to 0.11; P = 0.04 and 0.02, respectively).	alizarin	142-144	C-reactive protein	Homo sapiens	32-50
20053388-11	2010	Micromass cultures treated with lansoprazole, a small-molecule inhibitor of PHOSPHO1 activity, or FGF2, an inhibitor of chondrocyte differentiation, resulted in reduced alizarin red staining (P&lt;0.05).	alizarin	169-181	fibroblast growth factor 2	Gallus gallus	98-102
20459001-6	2010	The biological activity of hBMP-7 was assessed by mineralization of BMSCs detected by ALP staining and alizarin red staining.	alizarin	103-115	bone morphogenetic protein 7	Homo sapiens	27-33
19997757-8	2010	In contrast, reduction of AZ by AZsiRNA resulted in the small increase of beta-casein gene expression.	alizarin	26-28	casein beta	Mus musculus	74-85
20117994-8	2010	At day 50 of cell culture, the CD34(+)/CD117(+) cells exhibited positivity for von Kossa"s staining and alizarin red staining, but the mixed cells showed negative staining results.	alizarin	104-116	CD34 molecule	Homo sapiens	31-35
19771148-8	2009	We propose that SRPK79D is a novel T-bar-associated protein kinase that represses T-bar assembly in peripheral axons, and that SRPK79D-dependent repression must be relieved to facilitate site-specific AZ assembly.	alizarin	201-203	Serine-arginine protein kinase at 79D	Drosophila melanogaster	16-23
20095969-8	2009	Az inactivates ODC and targets it to ubiquitin-independent degradation by the 26S proteasome.	alizarin	0-2	ornithine decarboxylase 1	Homo sapiens	15-18
20095969-13	2009	As a result, it interferes with the binding of Az to ODC, thus rescuing ODC from degradation and permitting uptake of polyamines.	alizarin	47-49	ornithine decarboxylase 1	Homo sapiens	53-56
20095969-13	2009	As a result, it interferes with the binding of Az to ODC, thus rescuing ODC from degradation and permitting uptake of polyamines.	alizarin	47-49	ornithine decarboxylase 1	Homo sapiens	72-75
19851455-3	2009	BRP is required for intact AZ structure and normal evoked neurotransmitter release.	alizarin	27-29	bruchpilot	Drosophila melanogaster	0-3
19722797-6	2009	Pathologic changes in the CNP-treated gingival epithelial cells were observed with TEM, alizarin red staining, and disk-scanning confocal microscopy.	alizarin	88-100	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	26-29
19771148-8	2009	We propose that SRPK79D is a novel T-bar-associated protein kinase that represses T-bar assembly in peripheral axons, and that SRPK79D-dependent repression must be relieved to facilitate site-specific AZ assembly.	alizarin	201-203	Serine-arginine protein kinase at 79D	Drosophila melanogaster	127-134
19594024-9	2009	Alizarin red staining was performed on PRP group 14 days after culture to detect the formation of calcium nodule.	alizarin	0-12	caspase recruitment domain family member 14	Homo sapiens	39-42
19465028-3	2009	Az inhibitor (AzI) impairs the activity of Az.	alizarin	0-2	ornithine decarboxylase antizyme 1	Homo sapiens	14-17
19465028-7	2009	The data-driven docking results suggest that both proteins occupy the same binding site on Az, with Az binding within a large groove in AzI and ODC.	alizarin	91-93	ornithine decarboxylase antizyme 1	Homo sapiens	136-139
19465028-7	2009	The data-driven docking results suggest that both proteins occupy the same binding site on Az, with Az binding within a large groove in AzI and ODC.	alizarin	91-93	ornithine decarboxylase 1	Homo sapiens	144-147
19365811-9	2009	Calcium measurement and Alizarin red staining showed a reduction of mineralization by PRL while having neither an effect on osteoblast activity nor RANKL/OPG mRNA ratio.	alizarin	24-36	prolactin	Homo sapiens	86-89
19594024-15	2009	At 14 days after osteogenic induction, Alizarin red staining showed the formation of calcium nodule in PRP group.	alizarin	39-51	caspase recruitment domain family member 14	Homo sapiens	103-106
18996554-1	2009	The electrochemical removal of a synthetic solution containing 120mgL(-1) of alizarin red has been studied by electro-Fenton process using a gas-diffusion cathode to produce in situ hydrogen peroxide by oxygen reduction.	alizarin	77-89	LLGL scribble cell polarity complex component 1	Homo sapiens	66-72
18847334-7	2009	Furthermore, alizarin red and alkaline phosphatase staining were correlated with osteocalcin secretion and levels of expression of osteocalcin, osterix, bone sialoprotein, and Runx2.	alizarin	13-25	bone gamma-carboxyglutamate protein	Homo sapiens	81-92
18847334-7	2009	Furthermore, alizarin red and alkaline phosphatase staining were correlated with osteocalcin secretion and levels of expression of osteocalcin, osterix, bone sialoprotein, and Runx2.	alizarin	13-25	bone gamma-carboxyglutamate protein	Homo sapiens	131-142
18847334-7	2009	Furthermore, alizarin red and alkaline phosphatase staining were correlated with osteocalcin secretion and levels of expression of osteocalcin, osterix, bone sialoprotein, and Runx2.	alizarin	13-25	Sp7 transcription factor	Homo sapiens	144-151
18847334-7	2009	Furthermore, alizarin red and alkaline phosphatase staining were correlated with osteocalcin secretion and levels of expression of osteocalcin, osterix, bone sialoprotein, and Runx2.	alizarin	13-25	RUNX family transcription factor 2	Homo sapiens	176-181
17177849-6	2006	Alizarin Red histology and immunostaining showed a heightened level of mineralization and an increase in osteonectin, osteopontin, and collagen type I protein expression in both the induced and preinduced groups compared with the uninduced groups.	alizarin	0-12	secreted phosphoprotein 1	Homo sapiens	118-129
17188951-6	2007	At embryonic day 18.5, alizarin red/alcian blue staining showed that the Bgn/Dcn double deficient mice had hypomineralization of the frontal and parietal craniofacial bones.	alizarin	23-35	biglycan	Mus musculus	73-76
17255529-6	2007	Furthermore, overexpression of Axl significantly inhibits mineral deposition by VSMCs, as assessed by alizarin red staining and (45)Ca accumulation.	alizarin	102-114	AXL receptor tyrosine kinase	Homo sapiens	31-34
19106470-7	2008	The protein levels of phosphorylated-Smad1, Runx2, osteocalcin, osteopontin, and type I collagen were augmented by rhBMP-2 stimulation using Western blotting or ELISA; rhBMP-2 also stimulated mineralized nodule formation with alizarin red staining.	alizarin	226-238	mothers against decapentaplegic homolog 1	Oryctolagus cuniculus	37-42
17547533-9	2007	Examinations of newborn Osr2DeltaN transgenic mice skeletons stained with alcian blue and alizarin red showed reduced intensities in the skull and skeletal elements.	alizarin	90-102	odd-skipped related 2	Mus musculus	24-34
17058958-0	2006	[Fluorescence study on the interaction of alizarin yellow R and bovine serum albumin in alkali solution].	alizarin	42-50	albumin	Homo sapiens	71-84
16837257-4	2006	Alcian blue/alizarin red staining revealed that PHOSPHO1 expression seen in the primary regions of ossification preceded the deposition of mineral, suggesting that it is involved in the initial events of mineral formation.	alizarin	12-24	phosphoethanolamine/phosphocholine phosphatase	Gallus gallus	48-56
16203195-10	2006	An adenoviral-mediated overexpression of ZIP1 in MSCs resulted in Alizarin-red-positive mineralization and also increased expression of specific osteoblast-associated markers, such as alkaline phosphatase, and of several osteoblast differentiation genes, including osteopontin, Cbfa1/Runx2, promyelocytic leukemia zinc finger and bone sialoprotein.	alizarin	66-78	solute carrier family 39 member 1	Homo sapiens	41-45
16543132-9	2006	We propose that BRP is critical for intact AZ structure and normal-evoked neurotransmitter release at chemical synapses of Drosophila.	alizarin	43-45	bruchpilot	Drosophila melanogaster	16-19
16598380-7	2006	MATERIALS AND METHODS: In osteoblastogenic cultures, altered bone matrix production by Fra1 overexpression was monitored using Alizarin red staining, quantitative RT-PCR, and Western blotting.	alizarin	127-139	fos-like antigen 1	Mus musculus	87-91
12379470-0	2002	Inhibition of human cytochrome P450 1B1, 1A1 and 1A2 by antigenotoxic compounds, purpurin and alizarin.	alizarin	94-102	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	20-39
15491992-3	2004	Antizyme inhibitor (AzI) is an ODC-related protein that does not retain enzymatic activity yet binds Az with higher affinity than ODC.	alizarin	20-22	antizyme inhibitor 1	Homo sapiens	0-18
15491992-3	2004	Antizyme inhibitor (AzI) is an ODC-related protein that does not retain enzymatic activity yet binds Az with higher affinity than ODC.	alizarin	20-22	ornithine decarboxylase 1	Homo sapiens	31-34
15491992-3	2004	Antizyme inhibitor (AzI) is an ODC-related protein that does not retain enzymatic activity yet binds Az with higher affinity than ODC.	alizarin	20-22	ornithine decarboxylase 1	Homo sapiens	130-133
15491992-6	2004	Moreover, Az binding actually stabilizes AzI by inhibiting its ubiquitination.	alizarin	10-12	antizyme inhibitor 1	Homo sapiens	41-44
12695357-5	2003	The higher glucuronidation activity was measured with alizarin (125 pmol x min(-1) x mg protein(-1)), whereas UGT2B17 conjugated eugenol, scopoletin, and galangin with glucuronidation rates of 102.5, 102, and 58 pmol x min(-1) x mg protein(-1), respectively.	alizarin	54-62	CD59 molecule (CD59 blood group)	Homo sapiens	75-81
15271969-3	2004	Expression of both osteopontin and osteocalcin was induced by poly(P) (0.1 approximately 1 mM), and cells treated with poly(P) were strongly stained by alizarin red.	alizarin	152-164	secreted phosphoprotein 1	Mus musculus	19-30
15271969-3	2004	Expression of both osteopontin and osteocalcin was induced by poly(P) (0.1 approximately 1 mM), and cells treated with poly(P) were strongly stained by alizarin red.	alizarin	152-164	bone gamma-carboxyglutamate protein 2	Mus musculus	35-46
15363171-6	2004	The presence of mineralized bone matrix, extensive cell ingrowth, and cellular bridging between three-dimensional matrices adsorbed with P-15 was confirmed by confocal microscopy, scanning electron microscopy, and alizarin red staining.	alizarin	214-226	cyclin dependent kinase inhibitor 2B	Homo sapiens	137-141
13679380-4	2003	When we compared ATDC5 cells transfected with Cst10 cDNA with cells transfected with a mock vector, hypertrophic maturation and mineralization of chondrocytes were promoted by Cst10 gene overexpression in that type X collagen expression was observed earlier, and alizarin red staining was stronger.	alizarin	263-275	cystatin 10 (chondrocytes)	Mus musculus	46-51
13679380-4	2003	When we compared ATDC5 cells transfected with Cst10 cDNA with cells transfected with a mock vector, hypertrophic maturation and mineralization of chondrocytes were promoted by Cst10 gene overexpression in that type X collagen expression was observed earlier, and alizarin red staining was stronger.	alizarin	263-275	cystatin 10 (chondrocytes)	Mus musculus	176-181
12401884-8	2002	The results indicate that the dual PPARalpha/gamma agonism of AZ 242 reduces insulin resistance and has beneficial effects on FA and glucose metabolism.	alizarin	62-64	peroxisome proliferator activated receptor alpha	Mus musculus	35-44
12379470-4	2002	Purpurin and alizarin strongly inhibited the activities of CYP1A1, CYP1A2 and CYP1B1, and weakly suppressed those of CYP2A6 and CYP2E1 in a dose-dependent manner, but did not inhibit those of CYP2C19, CYP3A4 and CYP3A5.	alizarin	13-21	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	78-84
12379470-4	2002	Purpurin and alizarin strongly inhibited the activities of CYP1A1, CYP1A2 and CYP1B1, and weakly suppressed those of CYP2A6 and CYP2E1 in a dose-dependent manner, but did not inhibit those of CYP2C19, CYP3A4 and CYP3A5.	alizarin	13-21	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	117-123
12379470-4	2002	Purpurin and alizarin strongly inhibited the activities of CYP1A1, CYP1A2 and CYP1B1, and weakly suppressed those of CYP2A6 and CYP2E1 in a dose-dependent manner, but did not inhibit those of CYP2C19, CYP3A4 and CYP3A5.	alizarin	13-21	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	128-134
12379470-3	2002	The activities of eight human recombinant cytochrome P450 (CYP) isozymes were measured in the presence of purpurin, alizarin or carminic acid.	alizarin	116-124	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	42-57
12379470-4	2002	Purpurin and alizarin strongly inhibited the activities of CYP1A1, CYP1A2 and CYP1B1, and weakly suppressed those of CYP2A6 and CYP2E1 in a dose-dependent manner, but did not inhibit those of CYP2C19, CYP3A4 and CYP3A5.	alizarin	13-21	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	192-199
12379470-3	2002	The activities of eight human recombinant cytochrome P450 (CYP) isozymes were measured in the presence of purpurin, alizarin or carminic acid.	alizarin	116-124	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	59-62
12379470-4	2002	Purpurin and alizarin strongly inhibited the activities of CYP1A1, CYP1A2 and CYP1B1, and weakly suppressed those of CYP2A6 and CYP2E1 in a dose-dependent manner, but did not inhibit those of CYP2C19, CYP3A4 and CYP3A5.	alizarin	13-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	59-65
12379470-4	2002	Purpurin and alizarin strongly inhibited the activities of CYP1A1, CYP1A2 and CYP1B1, and weakly suppressed those of CYP2A6 and CYP2E1 in a dose-dependent manner, but did not inhibit those of CYP2C19, CYP3A4 and CYP3A5.	alizarin	13-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	201-207
12379470-4	2002	Purpurin and alizarin strongly inhibited the activities of CYP1A1, CYP1A2 and CYP1B1, and weakly suppressed those of CYP2A6 and CYP2E1 in a dose-dependent manner, but did not inhibit those of CYP2C19, CYP3A4 and CYP3A5.	alizarin	13-21	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	212-218
12379470-6	2002	CYP1B1 was the most strongly affected CYP molecule by purpurin and alizarin among CYPs examined in this study.	alizarin	67-75	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6
12379470-4	2002	Purpurin and alizarin strongly inhibited the activities of CYP1A1, CYP1A2 and CYP1B1, and weakly suppressed those of CYP2A6 and CYP2E1 in a dose-dependent manner, but did not inhibit those of CYP2C19, CYP3A4 and CYP3A5.	alizarin	13-21	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	67-73
12379470-6	2002	CYP1B1 was the most strongly affected CYP molecule by purpurin and alizarin among CYPs examined in this study.	alizarin	67-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
11499865-9	2001	Incubation of both hOBs entering the mineralization phase and osteosarcoma cell lines with recombinant leptin markedly increased the number of mineralized nodules as shown by alizarin S staining.	alizarin	175-185	leptin	Homo sapiens	103-109
12379470-10	2002	The K(m) value of CYP1B1 was 11 microM, and the K(i) value of purpurin and alizarin against CYP1B1 was 0.7 microM(2) and 0.5 microM, respectively.	alizarin	75-83	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	92-98
12379470-12	2002	The mutagenicity of MeIQx in TA1538 1A2/OR or 1B1/OR was suppressed by purpurin and alizarin but not by carminic acid.	alizarin	84-92	olfactory receptor family 1 subfamily B member 1	Homo sapiens	43-49
12379470-14	2002	These results suggest that the antigenotoxic activities of purpurin and alizarin can be explained by inhibition of CYP activities responsible for activating the mutagens.	alizarin	72-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	115-118
12369787-3	2002	BMP-2/insulin-treated cells became refractile without forming cartilaginous nodules and reached terminal differentiation, became positive for alizarin red staining, and developed considerable ALP activity.	alizarin	142-154	bone morphogenetic protein 2	Mus musculus	0-5
11597934-3	2001	Compared with rats treated for 1 week with warfarin alone, rats treated with warfarin plus osteoprotegerin at a dose of 1 mg/kg per day had dramatically reduced alizarin red staining for calcification in the aorta and in the carotid, hepatic, mesenteric, renal, and femoral arteries, and they had 90% lower levels of calcium and phosphate in the abdominal aorta (P&lt;0.001) and in tracheal ring cartilage (P&lt;0.01).	alizarin	161-173	TNF receptor superfamily member 11B	Rattus norvegicus	91-106
11587644-6	2001	Heteronuclear NMR data on PPARalpha in both the apo form and in complex with AZ 242 shows an overall stabilization of the LBD upon agonist binding.	alizarin	77-79	peroxisome proliferator activated receptor alpha	Homo sapiens	26-35
10623564-4	2000	ODC, in association with AZ, is degraded by the 26S proteasome in an ATP-dependent, but ubiquitin-independent, manner.	alizarin	25-27	ornithine decarboxylase 1	Homo sapiens	0-3
11295492-5	2001	Within ODC, there is a region that is required for AZ binding which lies on the surface of an alpha-beta barrel forming one domain of the ODC monomer.	alizarin	51-53	ornithine decarboxylase 1	Homo sapiens	7-10
11295492-5	2001	Within ODC, there is a region that is required for AZ binding which lies on the surface of an alpha-beta barrel forming one domain of the ODC monomer.	alizarin	51-53	ornithine decarboxylase 1	Homo sapiens	138-141
10980128-11	2000	Alizarin Red staining clearly showed that the elastin fibers were heavily calcified in the control group, whereas in BB-1101 group the calcification was scarce with few fibers showing initial calcification deposits.	alizarin	0-12	elastin	Rattus norvegicus	46-53
10207189-10	1999	Alizarin Red stained the matrix of particle associated cells and inter-particle cellular bridges in P-15-associated cultures, indicating mineralization.	alizarin	0-12	cyclin dependent kinase inhibitor 2B	Homo sapiens	100-104
9426396-2	1997	Skeletal staining of homozygous and heterozygous Del1 mice and their nontransgenic littermates with Alcian blue/Alizarin red revealed not only a dose-dependent retardation in the appearance of ossification centers in transgene-positive offspring but also abnormal shapes and proportions of their vertebral columns.	alizarin	112-124	collagen, type II, alpha 1	Mus musculus	49-53