PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17098582-4	2006	Nickel chloride (NiCl(2)) treatment also induced tumor promotion markers, viz., ornithine decarboxylase (ODC) activity and thymidine [(3)H] incorporation into renal DNA (p<0.001).	nicl	17-21	ornithine decarboxylase 1	Rattus norvegicus	80-103
19423160-7	2009	Application of the PTP inhibitor sodium orthovanadate (OV) also activated a sustained and tyrosine kinase dependent Ca(2+) response, blocked by NiCl and 2-APB.	nicl	144-148	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	19-22
19122379-5	2008	However, treatment with nickel chloride (NiCl(2)) (100, 300 and 400 microM), a putative Na(+)-Ca(2+) exchanger inhibitor, concentration-dependently reduced the vasorelaxant responses of CLME.	nicl	41-45	nascent polypeptide associated complex subunit alpha	Rattus norvegicus	88-96
16963134-9	2006	Concomitant administration of chelerythrine, H89, NiCl(2) and BAPTA totally abolished PACAP-stimulated EM66 secretion.	nicl	50-54	adenylate cyclase activating polypeptide 1	Bos taurus	86-91
17098582-4	2006	Nickel chloride (NiCl(2)) treatment also induced tumor promotion markers, viz., ornithine decarboxylase (ODC) activity and thymidine [(3)H] incorporation into renal DNA (p<0.001).	nicl	17-21	ornithine decarboxylase 1	Rattus norvegicus	105-108
12801682-3	2003	Drop-deposition of samples prepared in HEPES buffer with 1, 2 and 5mM NiCl(2) revealed the sensitivity of the mucin molecules to salt.	nicl	70-74	LOC100508689	Homo sapiens	110-115
15351857-6	2004	The calcium rise is mediated primarily by induction of a calcium entry mechanism involving the Na(+)-Ca(2+) exchanger operating in reverse mode, since it was blocked by inhibitors of Na(+)-Ca(2+) exchange, bepridil and 5 mM NiCl(2).	nicl	224-228	solute carrier family 8 member A1	Homo sapiens	95-117
15183461-3	2004	In addition to the rapid effect, we have also found that the eNOS mRNA and protein expression were augmented in HUVECs treated with PAHs at concentration as low as 0.1 microM for 24 h. These effects were abolished when the HUVECs were pretreated with the BAPTA, NiCl(2) and SKF96365, as well as SKF525A.	nicl	262-266	nitric oxide synthase 3	Homo sapiens	61-65
11566556-4	2001	The aim of our study is to assess the phenotype, cytokine production and autologous T-cell stimulatory capacity of the in vitro CD34+-derived dendritic cells after 24 hours of incubation with the metal allergen NiCl(2) (100-300 microM) and the irritant sodium dodecyl sulfate (SDS; 0.01%), in order to find a sensitive endpoint to discriminate between sensitizers and irritants.	nicl	211-215	CD34 molecule	Homo sapiens	128-132
12010971-4	2002	Mutation of the HP1338 gene (nikR) of H. pylori strain 26695 resulted in significant growth inhibition of the nikR mutant in the presence of supplementation with NiCl(2) at > or =100 microM, whereas the wild-type strain tolerated more than 10-fold-higher levels of NiCl(2).	nicl	162-166	nickel-responsive transcriptional regulator NikR	Helicobacter pylori 26695	16-22
12010971-4	2002	Mutation of the HP1338 gene (nikR) of H. pylori strain 26695 resulted in significant growth inhibition of the nikR mutant in the presence of supplementation with NiCl(2) at > or =100 microM, whereas the wild-type strain tolerated more than 10-fold-higher levels of NiCl(2).	nicl	268-272	nickel-responsive transcriptional regulator NikR	Helicobacter pylori 26695	16-22
11719426-3	2001	The present study found that exposure of cells to either Ni(3)S(2) or NiCl(2) could result in specific transactivation of nuclear factor of activated T cells (NFAT), although it did not show any activation of p53 or AP-1.	nicl	70-74	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	216-220
21843586-7	2011	In addition, NiCl(2) also markedly induced the activation of c-Jun N-terminal kinases (JNK), but not of extracellular signal-regulated kinase (ERK)1/2 and p38.	nicl	13-17	mitogen-activated protein kinase 8	Rattus norvegicus	61-85
10704730-5	2000	However, we were able to measure a significant reduction in potassium-stimulated NPY release (-60%) by using the nonselective voltage-dependent calcium channel blocker NiCl (30 microM) without any effect on basal release, as a positive control.	nicl	168-172	neuropeptide Y	Homo sapiens	81-84
10552213-5	1999	The augmented expression of CD86 induced by NiCl(2) and DNCB was significantly suppressed by DEX at concentrations in the range 10(-8) to 10(-5) M, which include concentrations less than its therapeutically effective concentration of 10(-7) M. Vit D3 also significantly suppressed NiCl(2)- and DNCB-induced augmented expression of CD86, at concentrations in the ranges 10(-9) to 10(-7) M and 10(-10) to 10(-7) M, respectively.	nicl	44-48	CD86 molecule	Homo sapiens	28-32
10552213-5	1999	The augmented expression of CD86 induced by NiCl(2) and DNCB was significantly suppressed by DEX at concentrations in the range 10(-8) to 10(-5) M, which include concentrations less than its therapeutically effective concentration of 10(-7) M. Vit D3 also significantly suppressed NiCl(2)- and DNCB-induced augmented expression of CD86, at concentrations in the ranges 10(-9) to 10(-7) M and 10(-10) to 10(-7) M, respectively.	nicl	44-48	CD86 molecule	Homo sapiens	331-335
10552213-5	1999	The augmented expression of CD86 induced by NiCl(2) and DNCB was significantly suppressed by DEX at concentrations in the range 10(-8) to 10(-5) M, which include concentrations less than its therapeutically effective concentration of 10(-7) M. Vit D3 also significantly suppressed NiCl(2)- and DNCB-induced augmented expression of CD86, at concentrations in the ranges 10(-9) to 10(-7) M and 10(-10) to 10(-7) M, respectively.	nicl	281-285	CD86 molecule	Homo sapiens	28-32
22648416-7	2012	In addition, the potent antioxidant N-acetylcysteine blocked EMT and expression of HIF-1alpha induced by NiCl(2), whereas the DNA methyltransferase inhibitor 5-aza-2"-deoxycytidine restored the down-regulation of E-cadherin induced by NiCl(2).	nicl	105-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-93
21843586-7	2011	In addition, NiCl(2) also markedly induced the activation of c-Jun N-terminal kinases (JNK), but not of extracellular signal-regulated kinase (ERK)1/2 and p38.	nicl	13-17	mitogen-activated protein kinase 8	Rattus norvegicus	87-90
21106238-9	2011	In addition, we observed a significant decreased firing frequency of action potentials of small DRG neurons induced by NMU, which could be abrogated by pretreatment of the cells with NiCl(2) (100 muM).	nicl	183-187	neuromedin U	Mus musculus	119-122
20844246-6	2010	Perfusing cells with Ca(2+)-free Krebs-Ringer bicarbonate solution (KRBS) or KRBS containing SOCC antagonists SKF-96365 or NiCl(2) attenuated the increases in basal [Ca(2+)](i) caused by BMP4.	nicl	123-127	bone morphogenetic protein 4	Rattus norvegicus	187-191
20045483-8	2010	IL-13 promoted the proliferation of ASMCs stimulated by serum; this effect was inhibited by nonspecific Ca(2+) channel blockers SKF-96365 and NiCl(2), by salmeterol, but not by salbutamol and dexamethasone.	nicl	142-146	interleukin 13	Rattus norvegicus	0-5