PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24669888-5	2014	The superposition of 4h and 4s in the colchicine-binding pocket of tubulin shows the binding posture of CA-4, 4h, and 4s are similar, as confirmed by the competitive binding assay where the ability of the ligands to replace tubulin-bound colchicine was measured.	4s	28-30	carbonic anhydrase 4	Mus musculus	104-108
24501204-10	2014	Surprisingly, in the region of higher magnetic moments (>=3.0 mu(B)), there is also a linear relationship between the 4s exchange splitting and the total magnetic moment with a slope of I(h)(4s) = (1.053 +- 0.016) eV /mu(B), which is nearly identical to I(3d) for magnetic moments up to 3.0 muB.	4s	121-123	ubiquitin like 3	Homo sapiens	65-70
24501204-10	2014	Surprisingly, in the region of higher magnetic moments (>=3.0 mu(B)), there is also a linear relationship between the 4s exchange splitting and the total magnetic moment with a slope of I(h)(4s) = (1.053 +- 0.016) eV /mu(B), which is nearly identical to I(3d) for magnetic moments up to 3.0 muB.	4s	121-123	ubiquitin like 3	Homo sapiens	221-226
24501204-10	2014	Surprisingly, in the region of higher magnetic moments (>=3.0 mu(B)), there is also a linear relationship between the 4s exchange splitting and the total magnetic moment with a slope of I(h)(4s) = (1.053 +- 0.016) eV /mu(B), which is nearly identical to I(3d) for magnetic moments up to 3.0 muB.	4s	194-196	ubiquitin like 3	Homo sapiens	65-70
24501204-10	2014	Surprisingly, in the region of higher magnetic moments (>=3.0 mu(B)), there is also a linear relationship between the 4s exchange splitting and the total magnetic moment with a slope of I(h)(4s) = (1.053 +- 0.016) eV /mu(B), which is nearly identical to I(3d) for magnetic moments up to 3.0 muB.	4s	194-196	ubiquitin like 3	Homo sapiens	221-226
22119860-3	2011	Loss of the [4Fe-4S] cofactor by cysteine ligand mutagenesis in Pol3 destabilized the CTD and abrogated interaction with the Pol31 and Pol32 subunits.	4s	17-19	DNA-directed DNA polymerase delta POL3	Saccharomyces cerevisiae S288C	64-68
22119860-3	2011	Loss of the [4Fe-4S] cofactor by cysteine ligand mutagenesis in Pol3 destabilized the CTD and abrogated interaction with the Pol31 and Pol32 subunits.	4s	17-19	DNA-directed DNA polymerase delta subunit POL31	Saccharomyces cerevisiae S288C	125-130
22119860-3	2011	Loss of the [4Fe-4S] cofactor by cysteine ligand mutagenesis in Pol3 destabilized the CTD and abrogated interaction with the Pol31 and Pol32 subunits.	4s	17-19	DNA polymerase delta subunit POL32	Saccharomyces cerevisiae S288C	135-140
17951579-3	2007	To investigate the degradation process, an authentic CS-E tetrasaccharide, Delta4,5HexUA-GalNAc(4S)-GlcUA(3S)-GalNAc(4S), was digested with CSase ABC, and the end product was identified as GalNAc(4S) by electrospray ionization mass spectrometry (ESI-MS).	4s	96-98	cystathionase (cystathionine gamma-lyase)	Mus musculus	53-57
19053409-6	2008	This result demonstrates a successful biomimetic reassembly of [4Fe-4S] cluster [Fe(4)S(4)(SPh)(4)](2-) from NO-modified [Fe-S] clusters, relevant to the repair of DNICs derived from nitrosylation of [4Fe-4S] clusters of endonuclease III back to [4Fe-4S] clusters upon addition of ferrous ion, cysteine, and IscS.	4s	68-70	surfactant associated 3	Homo sapiens	91-94
19053409-6	2008	This result demonstrates a successful biomimetic reassembly of [4Fe-4S] cluster [Fe(4)S(4)(SPh)(4)](2-) from NO-modified [Fe-S] clusters, relevant to the repair of DNICs derived from nitrosylation of [4Fe-4S] clusters of endonuclease III back to [4Fe-4S] clusters upon addition of ferrous ion, cysteine, and IscS.	4s	68-70	NFS1 cysteine desulfurase	Homo sapiens	308-312
16027724-7	2005	Intriguingly, serine 281 belongs to a conserved motif of four evenly spaced serines (the 4S motif) similar to the one controlling beta-catenin degradation by the proteasome pathway.	4s	89-91	catenin beta 1	Homo sapiens	130-142
17165777-9	2006	It was shown that wild-type NAL could not be used for the highly stereoselective synthesis of a 6-dipropylamide sialic acid mimetic because the 4S-configured product was only approximately 3-fold kinetically favored and only approximately 3-fold thermodynamically favored over the alternative 4R-configured product.	4s	144-146	N-acetylneuraminate pyruvate lyase	Homo sapiens	28-31
16373346-9	2006	When approximately 22-mer CS oligosaccharides were fractionated by strong anion exchange HPLC, each fraction differed in affinity for pleiotrophin (K(D) = 0.36 approximately >10 microM), and the affinity correlated with the amounts of D- and E- (GlcAbeta1-3GalNAc(4S,6S)) type oversulfated structures.	4s	267-269	pleiotrophin	Homo sapiens	134-146
16027724-8	2005	A nonphosphorylated mutant Cdx2 lacking the 4S motif (4S>A) exhibited reduced polyubiquitination upon proteasome inhibition and increased stability compared to wild-type Cdx2.	4s	44-46	caudal type homeobox 2	Homo sapiens	173-177
17401378-4	2007	Using in vivo and in vitro approaches, we found that the soluble P-loop NTPases Cfd1 and Nbp35 form a complex and bind up to three [4Fe-4S] clusters, one at the N terminus of Nbp35 and one each at a new C-terminal cysteine-rich motif present in both proteins.	4s	136-138	iron-sulfur cluster assembly protein CFD1	Saccharomyces cerevisiae S288C	80-84
17401378-4	2007	Using in vivo and in vitro approaches, we found that the soluble P-loop NTPases Cfd1 and Nbp35 form a complex and bind up to three [4Fe-4S] clusters, one at the N terminus of Nbp35 and one each at a new C-terminal cysteine-rich motif present in both proteins.	4s	136-138	Fe-S cluster-binding ATPase	Saccharomyces cerevisiae S288C	89-94
16236168-0	2005	Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/beta-catenin signaling.	4s	17-19	frizzled class receptor 4 S homeolog	Xenopus laevis	43-47
16236168-0	2005	Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/beta-catenin signaling.	4s	17-19	catenin beta 1 L homeolog	Xenopus laevis	102-114
16027724-8	2005	A nonphosphorylated mutant Cdx2 lacking the 4S motif (4S>A) exhibited reduced polyubiquitination upon proteasome inhibition and increased stability compared to wild-type Cdx2.	4s	44-46	caudal type homeobox 2	Homo sapiens	27-31
10723065-4	2000	Here we provide first evidence that TN-R derived from whole rat brain or cultured oligodendrocytes expresses chondroitin sulfate (CS) glycosaminoglycans (GAGs), i.e., C-4S and C-6S, that are recognized by CS-56, a CS/dermatan sulfate-specific monoclonal antibody.	4s	169-171	tenascin R	Rattus norvegicus	36-40
12820873-4	2003	The resonance Raman (RR) spectra of human recombinant holo-IRP1 (rhIRP1) excited at 457.9 nm show that the 395 cm(-1) band, attributed to a terminal Fe-S stretching mode of the cluster, is replaced by a 405 cm(-1) band, consistent with the conversion of the [4Fe-4S](2+) center to a [3Fe-4S](+) center, upon exposure to peroxynitrite.	4s	263-265	aconitase 1	Homo sapiens	59-63
10924112-3	2000	Reduction of the 6-(S)-cysteinyl FMN in TMADH is not affected by mutation of either Tyr-442 or Val-344 to a variety of alternate side chains, although there are modest changes in the rate of internal electron transfer from the 6-(S)-cysteinyl FMN to the 4Fe-4S center.	4s	258-260	formin 1	Homo sapiens	33-36
9245423-1	1997	In the rat, cytochrome P4501A1 gene expression is thought to be regulated by several trans-acting factors including the 4S polycyclic aromatic hydrocarbon (PAH)-binding protein, which was recently identified as glycine N-methyltransferase [Raha, A., Wagner, C., MacDonald, R. G., and Bresnick, E. (1994) J. Biol.	4s	120-122	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	12-30
9822220-6	1998	The 4S peak of [3H]TAZ was partially inhibited by both estrogens and antiestrogens.	4s	4-6	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	19-22
9245423-1	1997	In the rat, cytochrome P4501A1 gene expression is thought to be regulated by several trans-acting factors including the 4S polycyclic aromatic hydrocarbon (PAH)-binding protein, which was recently identified as glycine N-methyltransferase [Raha, A., Wagner, C., MacDonald, R. G., and Bresnick, E. (1994) J. Biol.	4s	120-122	glycine N-methyltransferase	Rattus norvegicus	211-238
7629796-6	1995	Binding affinity data for displacement of radiolabeled 4s from Jurkat cell membranes reflected an excellent correlation with the IC50 value for inhibition of beta-galactosidase activity.	4s	55-57	galactosidase beta 1	Homo sapiens	158-176
7805869-3	1994	In the reduced state the ferredoxin exhibited an EPR spectrum characteristic of two spin-coupled [4Fe-4S]1+ clusters.	4s	102-104	4Fe-4S binding protein	Methanosarcina barkeri MS	25-35
1431880-6	1992	Control over IRE-BP activity by the cellular iron status is exerted post-translationally and likely involves changes between (4Fe-4S) and (3Fe-4S) states of the postulated IRE-BP Fe-S cluster.	4s	130-132	aconitase 1	Homo sapiens	13-19
1431880-6	1992	Control over IRE-BP activity by the cellular iron status is exerted post-translationally and likely involves changes between (4Fe-4S) and (3Fe-4S) states of the postulated IRE-BP Fe-S cluster.	4s	130-132	aconitase 1	Homo sapiens	172-178
1431880-6	1992	Control over IRE-BP activity by the cellular iron status is exerted post-translationally and likely involves changes between (4Fe-4S) and (3Fe-4S) states of the postulated IRE-BP Fe-S cluster.	4s	143-145	aconitase 1	Homo sapiens	13-19
1431880-6	1992	Control over IRE-BP activity by the cellular iron status is exerted post-translationally and likely involves changes between (4Fe-4S) and (3Fe-4S) states of the postulated IRE-BP Fe-S cluster.	4s	143-145	aconitase 1	Homo sapiens	172-178
7214346-10	1981	The presence of the 4S binding species correlated with the level of inducibility of aryl hydrocarbon hydroxylase throughout its development in RL-PR-C and therefore may be involved in the process of induction of this enzyme.	4s	20-22	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	84-112
1381803-3	1992	Estrogen receptor (ER) from calf uterine cytosols sedimented as a 4S complex on gradients containing 0.4 M KCl and as an 8S entity on gradients without KCl.	4s	66-68	estrogen receptor 1	Bos taurus	0-17
1381803-3	1992	Estrogen receptor (ER) from calf uterine cytosols sedimented as a 4S complex on gradients containing 0.4 M KCl and as an 8S entity on gradients without KCl.	4s	66-68	estrogen receptor 1	Bos taurus	19-21
3320532-3	1987	Transformation of this complex to the 4S DNA-binding state is accompanied by dissociation of hsp90.	4s	38-40	heat shock protein 86, pseudogene 1	Mus musculus	93-98
6341612-6	1983	In spite of reduced levels of cytosolic ER, there was an apparent increase in the 8S/4S ratio (62% increase in 8S/4S ER ratio compared to control 8S/4S ratio; p less than 0.05).	4s	85-87	estrogen receptor 1	Rattus norvegicus	117-119
6341612-6	1983	In spite of reduced levels of cytosolic ER, there was an apparent increase in the 8S/4S ratio (62% increase in 8S/4S ER ratio compared to control 8S/4S ratio; p less than 0.05).	4s	114-116	estrogen receptor 1	Rattus norvegicus	117-119
6341612-6	1983	In spite of reduced levels of cytosolic ER, there was an apparent increase in the 8S/4S ratio (62% increase in 8S/4S ER ratio compared to control 8S/4S ratio; p less than 0.05).	4s	114-116	estrogen receptor 1	Rattus norvegicus	117-119
7189611-2	1980	Additional estrogen receptor also could be measured in some cytosols, and a quantitative temperature-dependent conversion of 8S to 4S binding molecules achieved.	4s	131-133	estrogen receptor 1	Homo sapiens	11-28
31459084-9	2018	However, 4s does not rescue cells from the death-inducing effects of Bax and betaA4, which suggest that 4s specifically inhibits alpha-syn-mediated toxicity in the yeast.	4s	104-106	synuclein alpha	Homo sapiens	129-138
30600851-6	2019	The data provide remarkable insight into the nitrosylation reactions, permitting identification, for the first time, of protein-bound mono-, di- and tetranitrosyl [4Fe-4S] cluster complexes ([4Fe-4S](NO), [4Fe-4S])(NO)2 and [4Fe-4S](NO)4 ) as intermediates along pathways to formation of product Roussin"s red ester (RRE) and Roussin"s black salt (RBS)-like species.	4s	168-170	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	326-346
30600851-6	2019	The data provide remarkable insight into the nitrosylation reactions, permitting identification, for the first time, of protein-bound mono-, di- and tetranitrosyl [4Fe-4S] cluster complexes ([4Fe-4S](NO), [4Fe-4S])(NO)2 and [4Fe-4S](NO)4 ) as intermediates along pathways to formation of product Roussin"s red ester (RRE) and Roussin"s black salt (RBS)-like species.	4s	168-170	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	348-351
30600851-6	2019	The data provide remarkable insight into the nitrosylation reactions, permitting identification, for the first time, of protein-bound mono-, di- and tetranitrosyl [4Fe-4S] cluster complexes ([4Fe-4S](NO), [4Fe-4S])(NO)2 and [4Fe-4S](NO)4 ) as intermediates along pathways to formation of product Roussin"s red ester (RRE) and Roussin"s black salt (RBS)-like species.	4s	196-198	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	326-346
30600851-6	2019	The data provide remarkable insight into the nitrosylation reactions, permitting identification, for the first time, of protein-bound mono-, di- and tetranitrosyl [4Fe-4S] cluster complexes ([4Fe-4S](NO), [4Fe-4S])(NO)2 and [4Fe-4S](NO)4 ) as intermediates along pathways to formation of product Roussin"s red ester (RRE) and Roussin"s black salt (RBS)-like species.	4s	196-198	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	348-351
30600851-6	2019	The data provide remarkable insight into the nitrosylation reactions, permitting identification, for the first time, of protein-bound mono-, di- and tetranitrosyl [4Fe-4S] cluster complexes ([4Fe-4S](NO), [4Fe-4S])(NO)2 and [4Fe-4S](NO)4 ) as intermediates along pathways to formation of product Roussin"s red ester (RRE) and Roussin"s black salt (RBS)-like species.	4s	196-198	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	326-346
30600851-6	2019	The data provide remarkable insight into the nitrosylation reactions, permitting identification, for the first time, of protein-bound mono-, di- and tetranitrosyl [4Fe-4S] cluster complexes ([4Fe-4S](NO), [4Fe-4S])(NO)2 and [4Fe-4S](NO)4 ) as intermediates along pathways to formation of product Roussin"s red ester (RRE) and Roussin"s black salt (RBS)-like species.	4s	196-198	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	348-351
26973057-5	2016	Detection of 2-HBP, a marker metabolite of 4S (sulfoxide-sulfone-sulfinate-sulfate) pathway, suggested that the newly isolated strains harbored metabolic activity for DBT desulfurization through the cleavage of C-S bond.	4s	43-45	heme binding protein 1	Homo sapiens	15-18
29762123-3	2018	Arylsulfatase B (ARSB) selectively cleaves 4S groups from the non-reducing ends of GAG chains without disrupting other, growth-permissive motifs.	4s	43-45	arylsulfatase B	Homo sapiens	0-15
29762123-3	2018	Arylsulfatase B (ARSB) selectively cleaves 4S groups from the non-reducing ends of GAG chains without disrupting other, growth-permissive motifs.	4s	43-45	arylsulfatase B	Homo sapiens	17-21
27574897-2	2017	beta-Ionone was found to be oxidized via 4S-hydroxylation by CYP2B6 in human liver microsomes.	4s	41-43	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	61-67
26820556-4	2016	N-(3-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)propyl)isonicotinamide (4s) with Ki = 0.130 nM, was the most active and selective derivative for the 5-HT1A receptor compared to other serotoninergic, dopaminergic and adrenergic receptors.	4s	74-76	5-hydroxytryptamine receptor 1A	Homo sapiens	151-166
26231575-3	2015	Here, we report that chondroitin 6-sulfation and chondroitin 6-sulfation-enriched PNNs increased in the mouse cerebral cortex and hippocampus after kainic acid (KA) treatment; simultaneously, chondroitin 4-sulfation-enriched PNNs and the 4S/6S ratio decreased.	4s	238-240	carbohydrate sulfotransferase 11	Mus musculus	192-205