PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33813310-0	2021	Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors.	benzofuran	15-25	plasmodium falciparum glycogen synthase kinase-3	None	66-114
7783126-13	1995	Unfavorable positions for substitution with bulky groups, like the 3- and 4-positions in the benzofuran compound 14, are explained by steric hindrance with the backbone atoms of helix V. Thus, we were able to rationalize the 5-HT1A SAR of existing N1-phenylpiperazines, as well as a series of newly synthesized bicyclic heteroarylpiperazines, in terms of receptor-ligand interactions.	benzofuran	93-103	5-hydroxytryptamine receptor 1A	Rattus norvegicus	225-231
1573630-9	1992	Two of the more active benzofuran compounds also significantly inhibited de novo cholesterol biosynthesis in EL4 cells which lack ER.	benzofuran	23-33	epilepsy 4	Mus musculus	109-112
33813310-2	2021	A series of benzofuran-based compounds was synthesised and evaluated as inhibitors of recombinantly expressed and purified PfGSK-3 and human glycogen synthase kinase-3 beta (HsGSK-3beta).	benzofuran	12-22	glycogen synthase kinase 3 beta	Homo sapiens	141-172
2552925-7	1989	The observed differential effects of the amiodarone analogs suggest that calmodulin may possess multiple benzofuran-binding sites that are recognized by specific targets and ligands of this Ca2+-binding protein and that the cellular action of amiodarone and its analogs may reflect calmodulin antagonism.	benzofuran	105-115	calmodulin 1	Homo sapiens	73-83
34675367-0	2021	Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new alpha-glucosidase inhibitor.	benzofuran	85-95	sucrase-isomaltase	Homo sapiens	111-128
34675367-1	2021	In this work, new derivatives of biphenyl pyrazole-benzofuran hybrids were designed, synthesized and evaluated in vitro through enzymatic assay for inhibitory effect against alpha-glucosidase activity.	benzofuran	51-61	sucrase-isomaltase	Homo sapiens	174-191
34383986-2	2021	Synthesis via 3-functionalized benzofuran yields syn -IDBF and syn -IIDBF.	benzofuran	31-41	synemin	Homo sapiens	49-52
34383986-2	2021	Synthesis via 3-functionalized benzofuran yields syn -IDBF and syn -IIDBF.	benzofuran	31-41	synemin	Homo sapiens	54-66
34267884-0	2021	Discovery and Optimization of a Series of Benzofuran Selective ERAP1 Inhibitors: Biochemical and In Silico Studies.	benzofuran	42-52	endoplasmic reticulum aminopeptidase 1	Homo sapiens	63-68
35510231-7	2022	Taken together, our preliminary investigations suggested that the rational deuteration of dronedarone at its benzofuran ring reduces aberrant cytochrome P450 3A4/5-mediated bioactivation, which attenuated its mitochondrial toxicity in human hepatic HepG2 cells.	benzofuran	109-119	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	142-163
34607808-5	2022	Herein binding and metabolism of the individual stereoisomers of the indole-based duocarmycin prodrug ICT2700 and a nontoxic benzofuran analog ICT2726 were evaluated with CYP1A1 and CYP2W1, revealing differences exploitable for drug design.	benzofuran	125-135	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	171-177
33327806-0	2021	Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3beta inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies.	benzofuran	15-25	cyclin dependent kinase 2	Homo sapiens	52-56
33327806-0	2021	Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3beta inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies.	benzofuran	15-25	glycogen synthase kinase 3 alpha	Homo sapiens	57-66
33327806-1	2021	The serine/threonine protein kinases CDK2 and GSK-3beta are key oncotargets in breast cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids were designed and synthesised as dual CDK2/GSK-3beta inhibitors targeting breast cancer (5a-g, 7a-h, and 13a-b).	benzofuran	162-172	cyclin dependent kinase 2	Homo sapiens	37-41
33327806-1	2021	The serine/threonine protein kinases CDK2 and GSK-3beta are key oncotargets in breast cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids were designed and synthesised as dual CDK2/GSK-3beta inhibitors targeting breast cancer (5a-g, 7a-h, and 13a-b).	benzofuran	162-172	glycogen synthase kinase 3 alpha	Homo sapiens	46-55
33327806-1	2021	The serine/threonine protein kinases CDK2 and GSK-3beta are key oncotargets in breast cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids were designed and synthesised as dual CDK2/GSK-3beta inhibitors targeting breast cancer (5a-g, 7a-h, and 13a-b).	benzofuran	162-172	cyclin dependent kinase 2	Homo sapiens	219-223
33327806-1	2021	The serine/threonine protein kinases CDK2 and GSK-3beta are key oncotargets in breast cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids were designed and synthesised as dual CDK2/GSK-3beta inhibitors targeting breast cancer (5a-g, 7a-h, and 13a-b).	benzofuran	162-172	glycogen synthase kinase 3 alpha	Homo sapiens	224-233
34771054-5	2021	Based on this view, new benzofuran/benzothiophene and thiosemicarbazone hybrid compounds were synthesized, characterized and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro fluorometric method.	benzofuran	24-34	monoamine oxidase B	Homo sapiens	155-161
34392176-2	2021	In this framework, we have developed in recent years a family of benzofuran compounds that act as Hsp90 allosteric modulators.	benzofuran	65-75	heat shock protein 90 alpha family class A member 1	Homo sapiens	98-103
34392176-5	2021	Western blotting, DARTS (i.e., Drug Affinity Responsive Target Stability) and enzymatic assays data confirmed a dose-dependent interaction of MDH2 with several members of the benzofuran Hsp90 modulators family and a computational model allowed to interpret the observed interactions.	benzofuran	175-185	malate dehydrogenase 2	Homo sapiens	142-146
34392176-5	2021	Western blotting, DARTS (i.e., Drug Affinity Responsive Target Stability) and enzymatic assays data confirmed a dose-dependent interaction of MDH2 with several members of the benzofuran Hsp90 modulators family and a computational model allowed to interpret the observed interactions.	benzofuran	175-185	heat shock protein 90 alpha family class A member 1	Homo sapiens	186-191
10418-1	1976	The benzofuran analog bufuralol, a beta-adrenergic blocker, was determined in blood and urine by a specific and sensitive spectrofluorometric assay.	benzofuran	4-14	amyloid beta precursor protein	Homo sapiens	33-39
2910914-3	1989	We report that the benzofuran amiodarone acts as a competitive antagonist to thyroid hormone action as defined by its dose-dependent ability to (a) bind to the thyroid hormone receptor and (b) inhibit T3-induced increases in growth hormone mRNA levels in a cultured rat pituitary cell line, GC cells.	benzofuran	19-29	gonadotropin releasing hormone receptor	Rattus norvegicus	225-239
12692651-0	1989	NTP Toxicology and Carcinogenesis Studies of Benzofuran (CAS No.	benzofuran	45-55	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	57-60
2514045-0	1989	Synthesis and aldose reductase-inhibitory activity of benzo[b]furan derivatives possessing a carboxymethylsulfamoyl group.	benzofuran	54-67	aldo-keto reductase family 1 member B	Homo sapiens	14-30
2514045-1	1989	Various benzo[b]furan derivatives with a carboxymethylsulfamoyl group were prepared and evaluated for aldose reductase-inhibitory potency.	benzofuran	8-21	aldo-keto reductase family 1 member B	Homo sapiens	102-118
3769053-6	1986	While the oxygen-containing coumaran and benzofuran both increased the NADH: quinone reductase activity in hepatic cytosol, the nitrogen-containing indole and indole-3-carbinol did not.	benzofuran	41-51	crystallin, zeta	Mus musculus	77-94
33836300-0	2021	Investigation of the arcane inhibition of human organic anion transporter 3 by benzofuran antiarrhythmic agents.	benzofuran	79-89	solute carrier family 22 member 8	Homo sapiens	48-75
33836300-3	2021	Benzbromarone, a known inhibitor of organic anion transporter 3 (OAT3), shares a benzofuran scaffold with amiodarone and dronedarone.	benzofuran	81-91	solute carrier family 22 member 8	Homo sapiens	36-63
33836300-3	2021	Benzbromarone, a known inhibitor of organic anion transporter 3 (OAT3), shares a benzofuran scaffold with amiodarone and dronedarone.	benzofuran	81-91	solute carrier family 22 member 8	Homo sapiens	65-69
33945992-0	2021	Design, synthesis and biological evaluation of novel benzofuran derivatives as potent LSD1 inhibitors.	benzofuran	53-63	lysine demethylase 1A	Homo sapiens	86-90
33945992-2	2021	Herein, a series of benzofuran derivatives were designed, synthesized and biochemical evaluated as novel LSD1 inhibitors based on scaffold hopping and conformational restriction strategy.	benzofuran	20-30	lysine demethylase 1A	Homo sapiens	105-109
33444985-3	2021	Substitution patterns on both the phenyl ring and the benzofuran moiety determine the affinity for MAO-A or MAO-B.	benzofuran	54-64	monoamine oxidase A	Homo sapiens	99-104
33128494-0	2021	Discovery of novel benzofuran scaffold as 4-hydroxyphenylpyruvate dioxygenase inhibitors.	benzofuran	19-29	4-hydroxyphenylpyruvate dioxygenase 1	Zea mays	42-77
33128494-8	2021	CONCLUSION: These results showed that the pyrazole-benzofuran structure could be used as possible lead compounds for the development of HPPD inhibitors.	benzofuran	51-61	4-hydroxyphenylpyruvate dioxygenase 1	Zea mays	136-140
33444985-3	2021	Substitution patterns on both the phenyl ring and the benzofuran moiety determine the affinity for MAO-A or MAO-B.	benzofuran	54-64	monoamine oxidase B	Homo sapiens	108-113
33332107-4	2021	In this study, we synthesized 17 benzofuran derivatives that may disaggregate Abeta oligomers and plaques into inert monomers.	benzofuran	33-43	amyloid beta (A4) precursor protein	Mus musculus	78-83
33332107-0	2021	Orally Administered Benzofuran Derivative Disaggregated Abeta Plaques and Oligomers in the Brain of 5XFAD Alzheimer Transgenic Mouse.	benzofuran	20-30	amyloid beta (A4) precursor protein	Mus musculus	56-61
32875347-9	2020	RESULTS: All four benzofuran derivatives were substrate-type releasers at dopamine transporters (DAT), norepinephrine transporters (NET), and serotonin transporters (SERT) with nanomolar potencies, similar to the profile of effects produced by MDA and MDMA.	benzofuran	18-28	solute carrier family 6 member 3	Rattus norvegicus	74-95
31809607-1	2020	Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a-c, and 10a-d), featuring the zinc anchoring benzenesulfonamide moiety linked to a benzofuran tail via a hydrazine or hydrazide linker.	benzofuran	143-153	carbonic anhydrase 9	Homo sapiens	55-61
31809607-1	2020	Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a-c, and 10a-d), featuring the zinc anchoring benzenesulfonamide moiety linked to a benzofuran tail via a hydrazine or hydrazide linker.	benzofuran	143-153	carbonic anhydrase 12	Homo sapiens	66-73
31809607-2	2020	All the target benzofurans were examined for their inhibitory activities toward isoforms hCA I, II, IX, and XII.	benzofuran	15-26	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	89-111
33085807-5	2021	A variety of heteroarenes, including indoles, pyrroles, benzofuran and benzothiophene, thereby underwent this C(sp 2 )-H nitrogenation.	benzofuran	56-66	Sp2 transcription factor	Homo sapiens	110-116
32875347-9	2020	RESULTS: All four benzofuran derivatives were substrate-type releasers at dopamine transporters (DAT), norepinephrine transporters (NET), and serotonin transporters (SERT) with nanomolar potencies, similar to the profile of effects produced by MDA and MDMA.	benzofuran	18-28	solute carrier family 6 member 3	Rattus norvegicus	97-100
32875347-9	2020	RESULTS: All four benzofuran derivatives were substrate-type releasers at dopamine transporters (DAT), norepinephrine transporters (NET), and serotonin transporters (SERT) with nanomolar potencies, similar to the profile of effects produced by MDA and MDMA.	benzofuran	18-28	solute carrier family 6 member 4	Rattus norvegicus	142-164
32875347-9	2020	RESULTS: All four benzofuran derivatives were substrate-type releasers at dopamine transporters (DAT), norepinephrine transporters (NET), and serotonin transporters (SERT) with nanomolar potencies, similar to the profile of effects produced by MDA and MDMA.	benzofuran	18-28	solute carrier family 6 member 4	Rattus norvegicus	166-170
32711085-0	2020	Novel bis(pyrazole-benzofuran) hybrids possessing piperazine linker: Synthesis of potent bacterial biofilm and MurB inhibitors.	benzofuran	19-30	Bis protein	Escherichia coli	6-9
33017718-4	2020	In this study, we investigated a series of sulfonate and sulfamate derivatives of benzofuran and benzothiophene as potent and selective inhibitors of NPP1 and NPP3.	benzofuran	82-92	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	150-154
33017718-4	2020	In this study, we investigated a series of sulfonate and sulfamate derivatives of benzofuran and benzothiophene as potent and selective inhibitors of NPP1 and NPP3.	benzofuran	82-92	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	159-163
32884238-0	2020	New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis.	benzofuran	4-14	tumor necrosis factor	Rattus norvegicus	92-101
32608259-0	2021	Benzofuran derivatives with nerve growth factor-potentiating activity from Phellinus ribis.	benzofuran	0-10	nerve growth factor	Rattus norvegicus	28-47
32480301-0	2020	Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.	benzofuran	31-41	bone morphogenetic protein 2	Rattus norvegicus	74-102
32417696-3	2020	Methoxy substitution and location on the benzene part of the benzo[b]furan ring played an important role in affecting antiproliferative activity, with the greatest activity occurring with the methoxy group at the C-6 position, the least with the substituent at C-4.	benzofuran	61-74	complement C6	Homo sapiens	213-216
32417696-3	2020	Methoxy substitution and location on the benzene part of the benzo[b]furan ring played an important role in affecting antiproliferative activity, with the greatest activity occurring with the methoxy group at the C-6 position, the least with the substituent at C-4.	benzofuran	61-74	complement C4A (Rodgers blood group)	Homo sapiens	261-264
32417696-4	2020	The same effect was also observed with ethoxy, methyl or bromine at the C-6 position of the benzo[b]furan skeleton, with the 6-ethoxy-2-amino-3-(3",4",5"-trimethoxybenzoyl)benzo[b]furan derivative 4f as the most promising compound of the series.	benzofuran	92-105	complement C6	Homo sapiens	72-75
32092557-0	2020	Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-gamma ligand-binding activity.	benzofuran	0-10	peroxisome proliferator activated receptor gamma	Mus musculus	81-91
32092557-5	2020	In particular, the undescribed benzofuran derivative, 3-[6,7-furano-9-hydroxy-4-(2"",3""-dihydroxy-3""-methylbutyloxy)]-phenyl propionic acid, exhibited the most potent PPAR-gamma ligand-binding activity and accumulated intracellular lipid in 3T3-L1 cells.	benzofuran	31-41	peroxisome proliferator activated receptor gamma	Mus musculus	169-179
32435420-3	2020	Superiorly, benzofuran-containing carboxylic acid derivatives 9b, 9e, and 9f acted as submicromolar hCA IX inhibitors with KIs = 0.91, 0.79, and 0.56 muM, respectively, with selective inhibitory profile against the target hCA IX over the off-target isoforms hCA I and II (SIs: 2 to >63 and 4-47, respectively).	benzofuran	12-22	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	258-270
32346326-0	2020	Spiroindolone analogues bearing benzofuran moiety as a selective cyclooxygenase COX-1 with TNF-alpha and IL-6 inhibitors.	benzofuran	32-42	tumor necrosis factor	Homo sapiens	91-100
32346326-0	2020	Spiroindolone analogues bearing benzofuran moiety as a selective cyclooxygenase COX-1 with TNF-alpha and IL-6 inhibitors.	benzofuran	32-42	interleukin 6	Homo sapiens	105-109
31944773-3	2020	Notablely, the resultant products can be smoothly converted into CF2-containing benzofurans, benzothiophenes and indoles through an isomerization process catalyzed by Fe(OTf)3.	benzofuran	80-91	ATPase H+ transporting accessory protein 1	Homo sapiens	65-68
31951313-0	2020	BF12, a novel benzofuran, exhibits anti-tumor activity by inhibiting microtubules and the PI3K/Akt/mTOR signaling pathway in human cervical cancer cells.	benzofuran	14-24	mechanistic target of rapamycin kinase	Homo sapiens	99-103
31944773-3	2020	Notablely, the resultant products can be smoothly converted into CF2-containing benzofurans, benzothiophenes and indoles through an isomerization process catalyzed by Fe(OTf)3.	benzofuran	80-91	POU class 5 homeobox 1	Homo sapiens	170-175
31838898-1	2019	Aim: Highlighting the need for effective therapies for the treatment of ulcerative colitis, novel series of potential CB2 modulators (benzofuran and pyrrole carboxamides) were developed and tested for their functional activities on CB1/CB2 receptors.	benzofuran	134-144	cannabinoid receptor 2 (macrophage)	Mus musculus	118-121
31994471-8	2020	RESULTS: The benzofuran derivative 3m showed encouraging growth inhibition of both MDAMB-231 and MCF-7 cell lines and significant inhibition of SIRT1.	benzofuran	13-23	sirtuin 1	Homo sapiens	144-149
31994471-10	2020	CONCLUSION: Our efforts not only accomplished a one-pot and direct access to 2-(het)aryl substituted benzofurans but also revealed that the benzofuran framework presented here could be a potential template for the identification of potent inhibitors of SIRT1.	benzofuran	101-112	sirtuin 1	Homo sapiens	253-258
31994471-10	2020	CONCLUSION: Our efforts not only accomplished a one-pot and direct access to 2-(het)aryl substituted benzofurans but also revealed that the benzofuran framework presented here could be a potential template for the identification of potent inhibitors of SIRT1.	benzofuran	101-111	sirtuin 1	Homo sapiens	253-258
31935604-1	2020	A docking study of a novel series of benzofuran derivatives with ERalpha was conducted.	benzofuran	37-47	estrogen receptor 1	Homo sapiens	65-72
31974638-0	2020	Synthesis and validation of [18F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone.	benzofuran	102-112	mechanistic target of rapamycin kinase	Homo sapiens	65-69
31974638-5	2020	Based on the structure of a mTOR inhibitor specific for mTORC1, we designed, synthesised and characterised a novel benzofuran based molecular probe which suits late stage fluorination via Click chemistry.	benzofuran	115-125	mechanistic target of rapamycin kinase	Homo sapiens	28-32
31974638-5	2020	Based on the structure of a mTOR inhibitor specific for mTORC1, we designed, synthesised and characterised a novel benzofuran based molecular probe which suits late stage fluorination via Click chemistry.	benzofuran	115-125	CREB regulated transcription coactivator 1	Mus musculus	56-62
31838898-2	2019	Results: In the benzofuran series, the cannabinoid (CB) receptor selectivity and the functional profile were dependent on the nature of the amide substituent and the position of the methoxy group, meanwhile the pyrrole derivatives, displayed an exclusive selectivity to the CB2 receptor and a functionality that is controlled by the nature of the pyrrole nitrogen substituent.	benzofuran	16-26	cannabinoid receptor 2 (macrophage)	Mus musculus	274-277
31527036-1	2019	Amphihevir, a benzofuran derivative, is the first reported NS4B inhibitor that has advanced to clinical trials (currently in Phase Ib).	benzofuran	14-24	polyprotein;protein F	Hepatitis C virus genotype 1	59-63
31394372-0	2019	Benzo[a]pyrene and 2,3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio).	benzofuran	19-33	aryl hydrocarbon receptor 1a	Danio rerio	72-75
31432548-1	2019	Direct dimesitylborylation of benzofuran derivatives by a C-H activation catalyzed by an iridium(I)/N-heterocyclic carbene (NHC) complex in the presence of Ph2 MeSi-BMes2 afforded the corresponding dimesitylborylation products in good to high yield with excellent regioselectivity.	benzofuran	30-40	polyhomeotic homolog 2	Homo sapiens	156-159
31726720-5	2019	We next generated a limited library of 91 analogues of SY000 and identified SY009, with modifications to the benzofuran ring associated with a 10-fold increase in potency towards EPAC1 over SY000 in binding assays.	benzofuran	109-119	Rap guanine nucleotide exchange factor 3	Homo sapiens	179-184
31345748-0	2019	Sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as potent carbonic anhydrase II/IX/XII inhibitors.	benzofuran	47-57	carbonic anhydrase 2	Homo sapiens	94-115
29745292-0	2019	Unraveling the molecular mechanism of benzothiophene and benzofuran scaffold-merged compounds binding to anti-apoptotic Myeloid cell leukemia 1.	benzofuran	57-67	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	120-143
31372616-2	2019	Using trifluoroacetic acid (TFA) as the catalyst and N-bromobutanimide (NBS) as the oxidant, 2-hydroxy-1,4-diones underwent a cyclization/oxidative aromatization cascade reaction to afford a variety of benzofuran derivatives in moderate to good yields.	benzofuran	202-212	nibrin	Homo sapiens	72-75
30696844-0	2019	Novel benzofuran derivative DK-1014 attenuates lung inflammation via blocking of MAPK/AP-1 and AKT/mTOR signaling in vitro and in vivo.	benzofuran	6-16	jun proto-oncogene	Mus musculus	86-90
30637844-1	2019	We herein demonstrate that the combination of LiO-tBu, CsF, and [18]crown-6 efficiently promotes the direct C-H carboxylation of electron-rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives).	benzofuran	184-194	colony stimulating factor 2	Homo sapiens	55-58
30958028-0	2019	Visnagin and benzofuran scaffold-based molecules as selective cyclooxygenase-2 inhibitors with anti-inflammatory and analgesic properties: design, synthesis and molecular docking.	benzofuran	13-23	prostaglandin-endoperoxide synthase 2	Mus musculus	62-78
30696844-0	2019	Novel benzofuran derivative DK-1014 attenuates lung inflammation via blocking of MAPK/AP-1 and AKT/mTOR signaling in vitro and in vivo.	benzofuran	6-16	thymoma viral proto-oncogene 1	Mus musculus	95-98
30696844-0	2019	Novel benzofuran derivative DK-1014 attenuates lung inflammation via blocking of MAPK/AP-1 and AKT/mTOR signaling in vitro and in vivo.	benzofuran	6-16	mechanistic target of rapamycin kinase	Mus musculus	99-103
30278208-0	2018	Bacterial respiratory tract inflammation in neonatal rat model is attenuated by benzofuran through inhibition of GATA3.	benzofuran	80-90	GATA binding protein 3	Rattus norvegicus	113-118
30160188-2	2018	The rationale of this study was the conjugation of a benzylpiperidine/benzylpiperazine moiety with derivatives of bioactive heterocyclics (benzimidazole or benzofuran), to mimic the main structure of DNP and to endow the hybrids with additional relevant properties such as inhibition of amyloid beta (Abeta) peptide aggregation, antioxidant activity and metal chelation.	benzofuran	156-166	amyloid beta precursor protein	Homo sapiens	287-299
30160188-2	2018	The rationale of this study was the conjugation of a benzylpiperidine/benzylpiperazine moiety with derivatives of bioactive heterocyclics (benzimidazole or benzofuran), to mimic the main structure of DNP and to endow the hybrids with additional relevant properties such as inhibition of amyloid beta (Abeta) peptide aggregation, antioxidant activity and metal chelation.	benzofuran	156-166	amyloid beta precursor protein	Homo sapiens	301-306
30261256-1	2019	Four 4-nitrophenyl-functionalized benzofuran (BF1, BF2) and benzodifuran (BDF1, BDF2) compounds were synthesized by a convenient route based on the Craven reaction.	benzofuran	34-44	forkhead box G1	Homo sapiens	46-49
30261256-1	2019	Four 4-nitrophenyl-functionalized benzofuran (BF1, BF2) and benzodifuran (BDF1, BDF2) compounds were synthesized by a convenient route based on the Craven reaction.	benzofuran	34-44	forkhead box G1	Homo sapiens	51-54
30278208-18	2018	These finding suggest that benzofuran inhibits expression of dominant T-helper 2 cytokines through targeting GATA-binding protein 3 transcription factor.	benzofuran	27-37	GATA binding protein 3	Rattus norvegicus	109-131
30278208-13	2018	The level of IFN-gamma was increased by benzofuran treatment in methacholine administered rats.	benzofuran	40-50	interferon gamma	Rattus norvegicus	13-22
30278208-16	2018	Benzofuran treatment of methacholine administered rats prevented reduction in T-bet and up-regulation of GATA-3 expression in the rat lungs.	benzofuran	0-10	GATA binding protein 3	Rattus norvegicus	105-111
29866481-0	2018	Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.	benzofuran	47-57	butyrylcholinesterase	Homo sapiens	112-133
30006156-5	2018	Moreover, molecular dynamics simulations demonstrated that both benzofuran and pyran moieties are requisite to fit into the active site of BMP-2 receptor, a key target of the osteogenic agents.	benzofuran	64-74	bone morphogenetic protein 2	Rattus norvegicus	139-144
29866481-1	2018	A series of bezofuran appended 1,5-benzothiazepine compounds 7a-v was designed, synthesized and evaluated as cholinesterase inhibitors.	benzofuran	12-21	butyrylcholinesterase	Homo sapiens	109-123
29722782-2	2018	Thanks to this novel synthetic strategy, a library of benzofuran-based potential allosteric activators of the Heat shock protein 90 (Hsp90) was easily prepared.	benzofuran	54-64	heat shock protein 90 alpha family class A member 1	Homo sapiens	110-131
29742314-4	2018	This article focuses on the history and recent advances of benzofuran- and indole-based compounds as inhibitors of butyrylcholinesterase, acetylcholinesterase, gamma-secretase, beta-secretase, tau misfolding, and beta-amyloid aggregation.	benzofuran	59-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	138-158
29742314-4	2018	This article focuses on the history and recent advances of benzofuran- and indole-based compounds as inhibitors of butyrylcholinesterase, acetylcholinesterase, gamma-secretase, beta-secretase, tau misfolding, and beta-amyloid aggregation.	benzofuran	59-69	microtubule associated protein tau	Homo sapiens	193-196
29722782-2	2018	Thanks to this novel synthetic strategy, a library of benzofuran-based potential allosteric activators of the Heat shock protein 90 (Hsp90) was easily prepared.	benzofuran	54-64	heat shock protein 90 alpha family class A member 1	Homo sapiens	133-138
29722782-4	2018	Combining experimental and computational results, we propose a mechanism of action for these compounds, and expand the structure-activity relationship (SAR) information available for benzofuran-based Hsp90 activators.	benzofuran	183-193	heat shock protein 90 alpha family class A member 1	Homo sapiens	200-205
29456795-1	2018	A novel series of benzofuran derived EZH2 inhibitors were discovered through a scaffold hopping approach based on the clinical compound of EPZ-6438.	benzofuran	18-28	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	37-41
29459207-3	2018	We present the design of a group of sulfated benzofuran dimers that display heparin-binding site-dependent partial allosteric inhibition of thrombin against fibrinogen (DeltaY = 55-75%), the first time that a small molecule (MW  < 800) has been found to thwart macromolecular cleavage by a monomeric protease in a controlled manner.	benzofuran	45-55	coagulation factor II, thrombin	Homo sapiens	140-148
29459207-3	2018	We present the design of a group of sulfated benzofuran dimers that display heparin-binding site-dependent partial allosteric inhibition of thrombin against fibrinogen (DeltaY = 55-75%), the first time that a small molecule (MW  < 800) has been found to thwart macromolecular cleavage by a monomeric protease in a controlled manner.	benzofuran	45-55	fibrinogen beta chain	Homo sapiens	157-167
29310080-0	2018	Synthesis and molecular docking study of new benzofuran and furo[3,2-g]chromone-based cytotoxic agents against breast cancer and p38alpha MAP kinase inhibitors.	benzofuran	45-55	mitogen-activated protein kinase 14	Homo sapiens	129-137
29310080-1	2018	This study deals with synthesis of a new set of benzofuran and 5H-furo[3,2-g]chromone linked various heterocyclic functionalities using concise synthetic approaches aiming to gain new antiproliferative candidates against MCF-7 breast cancer cells of p38alpha MAP kinase inhibiting activity.	benzofuran	48-58	mitogen-activated protein kinase 14	Homo sapiens	250-258
29317148-0	2018	Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold.	benzofuran	73-83	midkine	Mus musculus	54-57
29097030-5	2017	Furthermore, molecular modeling studies were performed to gain insight into the binding approach, which revealed that both benzofuran and dihydropyridine moieties are essential to show similar binding interactions to fit into the active site of BMP2 receptor, an important target of the osteogenic agents.	benzofuran	123-133	bone morphogenetic protein 2	Mandrillus leucophaeus	245-249
29161514-0	2018	Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a beta-Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer"s Disease.	benzofuran	36-46	amyloid beta (A4) precursor protein	Mus musculus	71-77
29376877-3	2018	Compounds containing a benzofuran ring have been described to play an important role in decreasing Abeta-induced toxicity; however, only synthetic benzofurans have been tested thus far.	benzofuran	23-33	amyloid beta precursor protein	Rattus norvegicus	99-104
29376877-9	2018	The results suggest a potent neuroprotective effect of this naturally occurring benzofuran against Abeta peptide toxicity that could be mediated by an interference with it binding to plasma membrane, and lead Fx as new chemical entity to develop pharmacological tools against Abeta peptide neurotoxicity.	benzofuran	80-90	amyloid beta precursor protein	Rattus norvegicus	99-104
29376877-9	2018	The results suggest a potent neuroprotective effect of this naturally occurring benzofuran against Abeta peptide toxicity that could be mediated by an interference with it binding to plasma membrane, and lead Fx as new chemical entity to develop pharmacological tools against Abeta peptide neurotoxicity.	benzofuran	80-90	amyloid beta precursor protein	Rattus norvegicus	276-281
29714012-2	2018	The method relies on an amber codon suppression strategy to genetically encode photo-activatable cross-linkers, such as p-azido-L-phenylalanine (azF) or p-benzoly-L-phenylalanine (BzF), in GPCRs expressed in mammalian cells in culture.	benzofuran	180-183	AZF1	Homo sapiens	145-148
28801979-5	2017	The Ph2 Ge-bridged indole, benzofuran, and benzothiophene-S,S-dioxide derivatives exhibit brilliant fluorescence in the violet-to-blue region with good-to-excellent quantum yields in toluene (lambdaem =376-439 nm, Phi=0.62-0.99) and powder form (lambdaem =401-451 nm, Phi=0.64-0.80).	benzofuran	27-37	polyhomeotic homolog 2	Homo sapiens	4-7
28554092-0	2017	Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1alpha pathway.	benzofuran	37-47	hypoxia inducible factor 1, alpha subunit	Mus musculus	155-165
28390993-0	2017	New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.	benzofuran	49-59	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	83-96
28323031-0	2017	An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-kappaB.	benzofuran	24-34	signal transducer and activator of transcription 3	Homo sapiens	90-95
28323031-0	2017	An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-kappaB.	benzofuran	24-34	nuclear factor kappa B subunit 1	Homo sapiens	100-109
28323031-1	2017	Four benzofuran-conjugated iridium(III) or rhodium (III)-based metal complexes are synthesized to screen as an inhibitor of STAT3 activity in prostate cancer cells.	benzofuran	5-15	signal transducer and activator of transcription 3	Homo sapiens	124-129
28805748-0	2017	Synthesis and Evaluation of Novel Benzofuran Derivatives as Selective SIRT2 Inhibitors.	benzofuran	34-44	sirtuin 2	Homo sapiens	70-75
28805748-1	2017	A series of benzofuran derivatives were designed and synthesized, and their inhibitory activites were measured against the SIRT1-3.	benzofuran	12-22	sirtuin 1	Homo sapiens	123-128
28805748-4	2017	The results of this research could provide informative guidance for further optimizing benzofuran derivatives as potent SIRT2 inhibitors.	benzofuran	87-97	sirtuin 2	Homo sapiens	120-125
28390993-0	2017	New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.	benzofuran	49-59	lysyl oxidase	Homo sapiens	97-100
28390993-1	2017	New molecular hybrids combining benzothiophene or its bioisostere benzofuran with rhodanine were synthesized as potential dual COX-2/5-LOX inhibitors.	benzofuran	66-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-132
28390993-1	2017	New molecular hybrids combining benzothiophene or its bioisostere benzofuran with rhodanine were synthesized as potential dual COX-2/5-LOX inhibitors.	benzofuran	66-76	arachidonate 5-lipoxygenase	Homo sapiens	133-138
27163512-0	2016	Discovery of Benzofuran Derivatives that Collaborate with Insulin-Like Growth Factor 1 (IGF-1) to Promote Neuroprotection.	benzofuran	13-23	insulin-like growth factor 1	Rattus norvegicus	58-86
27291301-8	2017	Taken collectively, these results indicate that mitochondria are target organelles for the benzofuran analogues and MDMA, which elicit cytotoxicity through mitochondrial failure, and the onset of cytotoxicity may depend on the initial and/or residual concentrations of 5-MAPB rather than on those of its metabolite 5-APB.	benzofuran	91-101	arginyl aminopeptidase	Rattus norvegicus	272-275
27101893-0	2016	Discovery and optimization of new benzofuran derivatives against p53-independent malignant cancer cells through inhibition of HIF-1 pathway.	benzofuran	34-44	tumor protein p53	Homo sapiens	65-68
27101893-0	2016	Discovery and optimization of new benzofuran derivatives against p53-independent malignant cancer cells through inhibition of HIF-1 pathway.	benzofuran	34-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-131
28108275-4	2017	We observed that benzofuran compounds bearing a phenyl or tert-butyl substituent alpha to the methoxycarbonyl group significantly inhibited anchorage-dependent and -independent cell growth, and induced G0/G1 cell cycle arrest in human estrogen receptor alpha positive (MCF-7 and T47D) and in triple negative MDA-MB-231 breast cancer cells, without affecting growth of MCF-10A normal breast epithelial cells.	benzofuran	17-27	estrogen receptor 1	Homo sapiens	235-258
28108275-5	2017	Mechanistically, benzofuran derivatives enhanced the cyclin-dependent kinase inhibitor p21Cip/WAF1 expression at both mRNA and protein levels and this occurs transcriptionally in an Sp1-dependent manner.	benzofuran	17-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	94-98
28108275-6	2017	Moreover, benzofuran derivatives induced apoptosis, increased poly (ADP-ribose) polymerase cleavage and Bax/Bcl-2 ratio along with a marked DNA fragmentation along with a marked DNA fragmentation and a strong increase in TUNEL-positive breast cancer cells.	benzofuran	10-20	BCL2 associated X, apoptosis regulator	Homo sapiens	104-107
28108275-6	2017	Moreover, benzofuran derivatives induced apoptosis, increased poly (ADP-ribose) polymerase cleavage and Bax/Bcl-2 ratio along with a marked DNA fragmentation along with a marked DNA fragmentation and a strong increase in TUNEL-positive breast cancer cells.	benzofuran	10-20	BCL2 apoptosis regulator	Homo sapiens	108-113
27291301-2	2017	The cytotoxic effects and mechanisms of 5-(2-aminopropyl)benzofuran (5-APB) and N-methyl-5-(2-aminopropyl)benzofuran (5-MAPB), both of which are benzofuran analogues of amphetamine, and 3,4-methylenedioxy-N-methamphetamine (MDMA) were studied in freshly isolated rat hepatocytes.	benzofuran	57-67	arginyl aminopeptidase	Rattus norvegicus	71-74
27163512-0	2016	Discovery of Benzofuran Derivatives that Collaborate with Insulin-Like Growth Factor 1 (IGF-1) to Promote Neuroprotection.	benzofuran	13-23	insulin-like growth factor 1	Rattus norvegicus	88-93
27163512-1	2016	A series of benzofuran derivatives with neuroprotective activity in collaboration with IGF-1 was discovered using a newly developed cell-based assay involving primary neural cells prepared from rat hippocampal and cerebral cortical tissues.	benzofuran	12-22	insulin-like growth factor 1	Rattus norvegicus	87-92
26991533-3	2016	Compounds selective for CLC-Ks, such as the benzofuran derivative MT-189, may have a significant therapeutic potential.	benzofuran	44-54	cardiotrophin-like cytokine factor 1	Rattus norvegicus	24-27
26995529-3	2016	Among these benzofuran derivatives, compound 16 exhibited the highest BChE inhibition with an IC50 value of 30.3 muM.	benzofuran	12-22	butyrylcholinesterase	Homo sapiens	70-74
26991533-6	2016	Based on MT-189, we designed and tested a new series of benzofuran derivatives on CLC-K chloride channels heterologously expressed in HEK293 cells.	benzofuran	56-66	cardiotrophin-like cytokine factor 1	Rattus norvegicus	82-85
26849160-1	2016	We have synthesized and established the structure of a long-suspected, but hitherto unknown, benzofuran side product (EBI) formed during the synthesis of NH-3.	benzofuran	93-103	transducin beta like 1 X-linked	Homo sapiens	118-121
26842845-5	2016	This inhibition was due to the Profilin mediated attenuation of IkappaBalpha degradation, thereby preventing p65 nuclear translocation and low NF-kappaB DNA binding activity.Moreover, Profilin increases level of p53 in the presence of known inducers, such as doxorubicin, vinblastine, and benzofuran.	benzofuran	289-299	tumor protein p53	Homo sapiens	212-215
26898337-5	2016	This study suggests that compounds 2, 4, 7 and 8 which are having 4-hydroxyphenyl group and/or hydroxy (-OH) group at 5- and/or 6-position of benzofuran motif could be considered as a promising scaffolds for the further development of iNOS inhibitors for potential anti-inflammatory applications.	benzofuran	142-152	nitric oxide synthase 2	Homo sapiens	235-239
25711990-0	2015	Metabolic fate, mass spectral fragmentation, detectability, and differentiation in urine of the benzofuran designer drugs 6-APB and 6-MAPB in comparison to their 5-isomers using GC-MS and LC-(HR)-MS(n) techniques.	benzofuran	96-106	arginyl aminopeptidase	Rattus norvegicus	124-127
27581632-4	2016	Among the title compounds, the series including benzofuran aromatic ring exhibited the best inhibitory activity both on AChE and BuChE enzymes.	benzofuran	48-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	120-124
27581632-4	2016	Among the title compounds, the series including benzofuran aromatic ring exhibited the best inhibitory activity both on AChE and BuChE enzymes.	benzofuran	48-58	butyrylcholinesterase	Homo sapiens	129-134
26594472-3	2015	Further, the O atom of the benzo-furan ring is syn to the N atom of the oxime group.	benzofuran	27-38	synemin	Homo sapiens	47-50
26313364-1	2015	Previously unknown, vertically linked heterocycles comprised of benzofuran and iminocoumarin moieties have been synthesized directly from 1,5-dibenzoyloxyanthraquinone and arylacetonitriles via double Knoevenagel condensation followed by formal HCN elimination.	benzofuran	64-74	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	245-248
25689681-7	2015	In addition to the expected activation of PPARalpha by fibrate drugs, di(2-ethylhexyl) phthalate, and perfluorinated compounds, PPARalpha was activated by benzofuran, galactosamine, and TCDD and suppressed by hepatotoxins acetaminophen, lipopolysaccharide, silicon dioxide nanoparticles, and trovafloxacin.	benzofuran	155-165	peroxisome proliferator activated receptor alpha	Mus musculus	128-137
25811180-3	2015	In a screen of a collection of diversity-oriented synthesis (DOS)-derived compounds, we identified a series of benzofuran-based compounds that upregulate TRIB1 expression and phenocopy the effects of TRIB1 cDNA overexpression, as they inhibit triglyceride synthesis and apoB secretion in cells.	benzofuran	111-121	tribbles pseudokinase 1	Homo sapiens	154-159
25811180-3	2015	In a screen of a collection of diversity-oriented synthesis (DOS)-derived compounds, we identified a series of benzofuran-based compounds that upregulate TRIB1 expression and phenocopy the effects of TRIB1 cDNA overexpression, as they inhibit triglyceride synthesis and apoB secretion in cells.	benzofuran	111-121	tribbles pseudokinase 1	Homo sapiens	200-205
25793444-5	2015	The cyclopentene obtained from the PPh3-catalyzed reaction of allenoate H2C C CH(COO-t-Bu) with enynal undergoes decarboxylation under the [Au]/[Ag] catalysis and forms a carboxylate-free benzofuran.	benzofuran	188-198	protein phosphatase 4 catalytic subunit	Homo sapiens	35-39
25681712-0	2015	Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors.	benzofuran	0-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	55-75
25874339-0	2015	Synthesis of a novel class of substituted benzothiophene or benzofuran derivatives as BMP-2 up-regulators and evaluation of the BMP-2-up-regulating effects in vitro and the effects on glucocorticoid-induced osteoporosis in rats.	benzofuran	60-70	bone morphogenetic protein 2	Rattus norvegicus	86-91
25462247-0	2015	In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor.	benzofuran	43-53	aurora kinase B	Homo sapiens	107-115
25462247-3	2015	Based on one of our previous high-throughput screening studies, we identified lead compound S6, a small-molecule benzofuran derivative that binds Aurora B and inhibits its kinase activity in vitro.	benzofuran	113-123	aurora kinase B	Homo sapiens	146-154
25227717-2	2014	Because the radionuclide (68)Ga (t1/2=68 min) for PET imaging could become an attractive alternative to (11)C and (18)F, we designed and synthesized a benzofuran derivative conjugated with a (68)Ga complex ((68)Ga-DOTA-C3-BF) as a novel Abeta imaging probe.	benzofuran	151-161	thyroid stimulating hormone receptor	Mus musculus	50-53
25227717-2	2014	Because the radionuclide (68)Ga (t1/2=68 min) for PET imaging could become an attractive alternative to (11)C and (18)F, we designed and synthesized a benzofuran derivative conjugated with a (68)Ga complex ((68)Ga-DOTA-C3-BF) as a novel Abeta imaging probe.	benzofuran	151-161	amyloid beta (A4) precursor protein	Mus musculus	237-242
24367676-5	2013	Longer substituents at the 2 position of the benzofuran ring promoted EYA3 binding and inhibition, but were less effective in cellular assays, likely reflecting non-specific protein binding and a resulting reduction in free, bio-available inhibitor.	benzofuran	45-55	EYA transcriptional coactivator and phosphatase 3	Homo sapiens	70-74
27486036-0	2014	Hybrids of the Benzofuran Core from Natural Products and the 2,4-Dihydroxy-5-isopropylbenzene Fragment as Potent Hsp90 Inhibitors: Design, Synthesis and Bioevaluation.	benzofuran	15-25	heat shock protein 90 alpha family class A member 1	Homo sapiens	113-118
27486036-3	2014	In this study, a novel class of hybrids of benzofuran, a privileged core from natural products, and 2,4-dihydroxy-5-isopropyl phenyl, an efficient fragment in Hsp90 inhibitors, were designed and synthesized.	benzofuran	43-53	heat shock protein 90 alpha family class A member 1	Homo sapiens	159-164
24831006-6	2014	Notably, 10 of the receptor variants with BzF in the Nt tail and 4 of those with BzF in ECLII cross-linked efficiently to SP, indicating that these 14 sites are juxtaposed to SP in the ligand-bound receptor.	benzofuran	81-84	tachykinin precursor 1	Homo sapiens	122-124
24607877-0	2014	Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: design, synthesis and evaluation as potential anti-inflammatory agents.	benzofuran	26-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-63
24831006-4	2014	We used amber codon suppression to introduce the photoreactive unnatural amino acid p-benzoyl-l-phenylalanine (BzF) at 11 selected individual positions in the Nt tail (residues 11-21) and 23 positions in the ECLII (residues 170(C-10)-193(C+13)) of NK1.	benzofuran	111-114	tachykinin receptor 1	Homo sapiens	248-251
24831006-6	2014	Notably, 10 of the receptor variants with BzF in the Nt tail and 4 of those with BzF in ECLII cross-linked efficiently to SP, indicating that these 14 sites are juxtaposed to SP in the ligand-bound receptor.	benzofuran	42-45	tachykinin precursor 1	Homo sapiens	122-124
24445311-0	2014	Benzofuran derivatives as a novel class of inhibitors of mTOR signaling.	benzofuran	0-10	mechanistic target of rapamycin kinase	Homo sapiens	57-61
24431456-5	2014	In electrophysiological recordings, BzF incorporation allowed selective and potent UV-driven photoinactivation of both homomeric (GluA2) and heteromeric (GluA2:GluA1) AMPA receptors.	benzofuran	36-39	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	130-135
24431456-5	2014	In electrophysiological recordings, BzF incorporation allowed selective and potent UV-driven photoinactivation of both homomeric (GluA2) and heteromeric (GluA2:GluA1) AMPA receptors.	benzofuran	36-39	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	154-159
24431456-5	2014	In electrophysiological recordings, BzF incorporation allowed selective and potent UV-driven photoinactivation of both homomeric (GluA2) and heteromeric (GluA2:GluA1) AMPA receptors.	benzofuran	36-39	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	160-165
23635904-0	2013	Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.	benzofuran	0-10	NAD(P)H quinone dehydrogenase 1	Homo sapiens	93-125
23260350-0	2013	Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase.	benzofuran	18-28	leukotriene A4 hydrolase	Homo sapiens	65-91
23589499-5	2013	5-Nitro-2-(4-methoxyphenyl)benzofuran (8) is the most active compound of the benzofuran series, presenting MAO-B selectivity and reversible inhibition (IC50 =140 nM).	benzofuran	27-37	monoamine oxidase B	Homo sapiens	107-112
23260350-6	2013	Benzofuran 28 showed dose responsive target engagement and provides a useful tool to explore a LTA(4)H inhibitor for the treatment of inflammatory diseases, such as asthma and inflammatory bowel disease (IBD).	benzofuran	0-10	leukotriene A4 hydrolase	Homo sapiens	95-102
24088703-3	2013	Among the synthesized compounds, we found the benzofuran and benzothiazole derivative as promising scaffolds for the developement of potent CaMKII inhibitors.	benzofuran	46-56	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	140-146
23902929-1	2013	benzofuran and coumarin derivatives as potent and selective inhibitors of CYP2A6.	benzofuran	0-10	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	74-80
23902929-3	2013	We prepared a series of benzofuran and coumarin derivatives that have inhibitory effects on the activity of human CYP2A6.	benzofuran	24-34	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	114-120
23902929-5	2013	Synthetic benzofuran (4-methoxybenzofuran: IC50=2.20 microM) and coumarin (5-methoxycoumarin: IC50=0.13 microM and 6-methoxycoumarin: IC50=0.64 microM) derivatives, which have more selective effects than those of methoxalen and menthofuran, exhibited comparable activities against CYP2A6.	benzofuran	10-20	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	281-287
23531218-0	2013	Benzofuran-based estrogen receptor alpha modulators as anti-cancer therapeutics: in silico and experimental studies.	benzofuran	0-10	estrogen receptor 1	Homo sapiens	17-40
23063401-1	2012	A novel series of combretastatin A-4 heterocyclic analogues was prepared by replacement of the B ring with indole, benzofurane or benzothiophene, attached at the C2 position.	benzofuran	115-126	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	33-36
23987088-0	2013	A three-dimensional chemical phase pharmacophore mapping, QSAR modelling and electronic feature analysis of benzofuran salicylic acid derivatives as LYP inhibitors.	benzofuran	108-118	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	149-152
22788964-2	2012	Earlier, we reported on the design of sulfated benzofuran dimers (SBDs) as allosteric inhibitors of thrombin (Sidhu et al.	benzofuran	47-57	coagulation factor II, thrombin	Homo sapiens	100-108
24155042-4	2012	Based on these findings, we designed and synthesized new PPARgamma ligands with a benzimidazole (agonists 4-5 and 4-6), benzothiophene (agonists 5-5 and 5-6) or benzofuran (agonists 6-5 and 6-6) moiety either at position 5 or 6 of the benzimidazole core structure.	benzofuran	161-171	peroxisome proliferator activated receptor gamma	Mus musculus	57-66
21873054-4	2011	Among the compounds synthesized, the benzofuran-substituted alpha,beta-unsaturated lactone 4h showed the best inhibitory activity toward IL-2 production in Jurkat e6-1 T lymphocytes (IC(50)=66.9 nM) without cytotoxicity at 10 muM.	benzofuran	37-47	interleukin 2	Homo sapiens	137-141
22863925-0	2012	Benzofuran derivatives inhibit 11beta-hydroxysteroid dehydrogenase type 1 activity in rat adipose tissue.	benzofuran	0-10	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	31-73
22863925-4	2012	The aim of this study was to investigate the inhibitory effect of benzofuran derivatives on 11beta-HSD1 in mesenteric adipose tissue from rodents.	benzofuran	66-76	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	92-103
22863925-5	2012	11beta-HSD1 activity was determined by incubation of rat mesenteric adipose tissue microsomes in the presence of reduced nicotinamide adenine dinucleotide phosphate (NADPH) with and without benzofuran derivatives (Compounds 1-14).	benzofuran	190-200	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-11
21676612-1	2011	We describe the discovery and optimization of a novel series of benzofuran EP(1) antagonists, leading to the identification of 26d, a novel nonacidic EP(1) antagonist which demonstrated efficacy in preclinical models of chronic inflammatory pain.	benzofuran	64-74	prostaglandin E receptor 1	Homo sapiens	75-80
21714536-7	2011	Structure-activity relationship analysis indicated that sulfation at the 5-position of the benzofuran scaffold was essential for targeting thrombin.	benzofuran	91-101	coagulation factor II, thrombin	Homo sapiens	139-147
21676612-1	2011	We describe the discovery and optimization of a novel series of benzofuran EP(1) antagonists, leading to the identification of 26d, a novel nonacidic EP(1) antagonist which demonstrated efficacy in preclinical models of chronic inflammatory pain.	benzofuran	64-74	prostaglandin E receptor 1	Homo sapiens	150-155
21116228-3	2010	All of the benzofuran derivatives have weak anti-AChE activities compared with the reference compound, donepezil.	benzofuran	11-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-53
21728961-4	2011	Quantitative structure-activity relationships of the ability of flavones, chalcones, xanthones, acridones and various benzopyrane/benzofurane derivatives to inhibit ABCG2-mediated drug efflux have led to pharmacophores and molecular models allowing to optimize the available hit compounds and to design new-generation lead compounds.	benzofuran	130-141	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	165-170
20824064-6	2010	CONCLUSIONS/SIGNIFICANCE: Several compounds from the flavonoid, indole and benzofuran chemical families emerged as binding partners and/or regulators of EAG1 channels.	benzofuran	75-85	potassium voltage-gated channel subfamily H member 1	Homo sapiens	153-157
24900286-0	2011	Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS. We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity.	benzofuran	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	48-52
24900286-0	2011	Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS. We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity.	benzofuran	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	150-154
24900286-0	2011	Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS. We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity.	benzofuran	133-143	sphingosine-1-phosphate receptor 1	Mus musculus	48-52
24900286-0	2011	Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS. We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity.	benzofuran	133-143	sphingosine-1-phosphate receptor 1	Mus musculus	150-154
20674099-5	2010	We conclude that these indole and benzofuran derivatives are promising reversible MAO-B inhibitors with a possible role in the treatment of neurodegenerative diseases such as Parkinson"s disease (PD).	benzofuran	34-44	monoamine oxidase B	Homo sapiens	82-87
20873816-1	2010	A controlled regioselective synthesis of either C-2 or C-3 substituted benzo[b]furans from readily accessible 1-(2-hydroxyphenyl)-2-chloroethanones is described.	benzofuran	71-85	complement C3	Homo sapiens	55-58
20542694-0	2010	Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists.	benzofuran	0-10	purinergic receptor P2Y1	Homo sapiens	49-64
20472557-0	2010	Novel derivative of benzofuran induces cell death mostly by G2/M cell cycle arrest through p53-dependent pathway but partially by inhibition of NF-kappaB.	benzofuran	20-30	tumor protein p53	Homo sapiens	91-94
20472557-0	2010	Novel derivative of benzofuran induces cell death mostly by G2/M cell cycle arrest through p53-dependent pathway but partially by inhibition of NF-kappaB.	benzofuran	20-30	nuclear factor kappa B subunit 1	Homo sapiens	144-153
20542694-1	2010	Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists.	benzofuran	0-10	purinergic receptor P2Y1	Homo sapiens	66-81
20088515-0	2010	Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-regulators: synthesis, structure-activity relationships, and preventive bone loss efficacies in senescence accelerated mice (SAMP6) and ovariectomized rats.	benzofuran	30-40	bone morphogenetic protein 2	Mus musculus	73-101
20088515-1	2010	In this work, substituted benzothiophene and benzofuran compounds were found to be a new class of potential anabolic agents by enhancing BMP-2 expression.	benzofuran	45-55	bone morphogenetic protein 2	Mus musculus	137-142
20088515-2	2010	A series of benzothiophene and benzofuran derivatives have been synthesized, and their activities of up-regulating BMP-2 and bone loss prevention efficacies in SAMP6 mice and OVX rats have been studied.	benzofuran	31-41	bone morphogenetic protein 2	Mus musculus	115-120
20088515-3	2010	Benzothiophenes 1, 3, 14, 4a, 7a, 8a, and benzofuran analogue 2 showed higher BMP-2 up-regulation rates in vitro.	benzofuran	42-52	bone morphogenetic protein 2	Mus musculus	78-83
20088515-6	2010	We have demonstrated that substituted benzothiophene and benzofuran derivatives, especially compounds 1 and 8a, enhance BMP-2 expression in vitro and in vivo and stimulate bone formation and trabecular connectivity restoration in vivo.	benzofuran	57-67	bone morphogenetic protein 2	Mus musculus	120-125
18419109-0	2008	Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.	benzofuran	0-10	butyrylcholinesterase	Homo sapiens	56-70
20034788-0	2010	Synthetic studies on selective adenosine A2A receptor antagonists: synthesis and structure-activity relationships of novel benzofuran derivatives.	benzofuran	123-133	adenosine A2a receptor	Homo sapiens	31-53
18991740-3	2008	SAR were elucidated with various substitutions on the benzoyl moiety at the 2-position of the benzofuran ring.	benzofuran	94-104	sarcosine dehydrogenase	Homo sapiens	0-3
20064720-0	2010	Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.	benzofuran	6-16	5-hydroxytryptamine receptor 1A	Homo sapiens	39-54
20064720-0	2010	Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.	benzofuran	6-16	solute carrier family 6 member 4	Homo sapiens	59-80
20064720-1	2010	Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT(1A) receptor affinities.	benzofuran	8-18	solute carrier family 6 member 4	Homo sapiens	125-146
19272775-0	2009	Synthesis, discovery and preliminary SAR study of benzofuran derivatives as angiogenesis inhibitors.	benzofuran	50-60	sarcosine dehydrogenase	Homo sapiens	37-40
18282708-0	2008	Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1" substituents.	benzofuran	128-138	ADAM metallopeptidase domain 17	Homo sapiens	53-98
18372181-2	2008	Introduction of a methoxycarbonylamino substituent in the C-5 position of the benzofurane nucleus obtains MT(3) selective ligands.	benzofuran	78-89	complement C5	Homo sapiens	58-61
18282708-0	2008	Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1" substituents.	benzofuran	128-138	ADAM metallopeptidase domain 17	Homo sapiens	100-104
18216243-8	2008	Surprisingly, some benzofuran-based drugs inhibit ClC-Kb with a similar affinity of <10 microM, thus representing the first inhibitors for this CLC-K isoform identified so far.	benzofuran	19-29	chloride voltage-gated channel Kb	Homo sapiens	50-56
17827777-1	2007	comparison of furanocoumarin, coumarin, and benzofuran dimers as potent inhibitors of CYP3A4 activity.	benzofuran	44-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
17827777-5	2007	We prepared a series of furanocoumarin, coumarin, and benzofuran derivatives that have inhibitory effects on the activity of human CYP3A4.	benzofuran	54-64	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-137
17827777-6	2007	A synthetic benzofuran dimer, which is more accessible than furanocoumarin dimers, exhibited activity against CYP3A4 comparable to that of furanocoumarin dimers.	benzofuran	12-22	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	110-116
17095232-0	2007	Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors.	benzofuran	13-23	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	49-55
17512197-0	2007	Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.	benzofuran	47-57	sarcosine dehydrogenase	Homo sapiens	14-17
17512197-4	2007	Further elucidation of the SAR led to the identification of benzofuran and indole based templates.	benzofuran	60-70	sarcosine dehydrogenase	Homo sapiens	27-30
16776510-2	2006	Benzofuran 4 provided a stable and easily handled intermediate for the preparation of unnatural derivatives at the C-6 position of MPA.	benzofuran	0-10	complement C6	Homo sapiens	115-118
16698271-0	2006	Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1.	benzofuran	6-16	dual specificity phosphatase 1	Homo sapiens	37-83
16776526-1	2006	Zn(OTf)2 (10 mol %) catalyzed the cyclization of propargyl alcohols with PhXH (X = O, NH) in hot toluene (100 degrees C) without additive and gave indole and benzofuran products with different structures.	benzofuran	158-168	POU class 2 homeobox 2	Homo sapiens	3-8
16451067-4	2006	Six of the benzofuran derivatives were subjected to in vitro cytotoxicity assays, using rat liver hepatocytes with cytotoxicity determined from alteration in cell morphology and lactate dehydrogenase enzyme retention over a period of 24 h, and selectivity (CYP17, 17beta-HSD types 1 and 3, CYP24, and CYP26) determination; negligible inhibitory activity was observed, suggesting a good selectivity for CYP19.	benzofuran	11-21	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	257-262
16451067-4	2006	Six of the benzofuran derivatives were subjected to in vitro cytotoxicity assays, using rat liver hepatocytes with cytotoxicity determined from alteration in cell morphology and lactate dehydrogenase enzyme retention over a period of 24 h, and selectivity (CYP17, 17beta-HSD types 1 and 3, CYP24, and CYP26) determination; negligible inhibitory activity was observed, suggesting a good selectivity for CYP19.	benzofuran	11-21	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	290-295
16451067-4	2006	Six of the benzofuran derivatives were subjected to in vitro cytotoxicity assays, using rat liver hepatocytes with cytotoxicity determined from alteration in cell morphology and lactate dehydrogenase enzyme retention over a period of 24 h, and selectivity (CYP17, 17beta-HSD types 1 and 3, CYP24, and CYP26) determination; negligible inhibitory activity was observed, suggesting a good selectivity for CYP19.	benzofuran	11-21	cytochrome P450, family 26, subfamily a, polypeptide 1	Rattus norvegicus	301-306
16451067-4	2006	Six of the benzofuran derivatives were subjected to in vitro cytotoxicity assays, using rat liver hepatocytes with cytotoxicity determined from alteration in cell morphology and lactate dehydrogenase enzyme retention over a period of 24 h, and selectivity (CYP17, 17beta-HSD types 1 and 3, CYP24, and CYP26) determination; negligible inhibitory activity was observed, suggesting a good selectivity for CYP19.	benzofuran	11-21	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	402-407
16078846-0	2005	Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives.	benzofuran	27-37	prostaglandin I2 receptor	Homo sapiens	82-103
15964760-4	2005	Varying substitution at the benzofuran moiety and subsequent antimicrobial screening identified the C-3-acetyl functionality as a new structural alternative for optimal antimicrobial property in the benzofuran class of compounds.	benzofuran	28-38	complement C3	Homo sapiens	100-103
15964760-4	2005	Varying substitution at the benzofuran moiety and subsequent antimicrobial screening identified the C-3-acetyl functionality as a new structural alternative for optimal antimicrobial property in the benzofuran class of compounds.	benzofuran	199-209	complement C3	Homo sapiens	100-103
15537353-5	2004	Models are presented for inhibition by benzofuran and benzothiophene biphenyl analogues of protein tyrosine phosphatase 1B (PTP1B), a target for insulin-resistant disease states.	benzofuran	39-49	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	91-122
15537353-5	2004	Models are presented for inhibition by benzofuran and benzothiophene biphenyl analogues of protein tyrosine phosphatase 1B (PTP1B), a target for insulin-resistant disease states.	benzofuran	39-49	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	124-129
15380212-3	2004	Modification of the benzofuran moiety and 4"-substituent of the phenyl ring in compound 1a improved selectivity at SGLT2.	benzofuran	20-30	solute carrier family 5 member 2	Homo sapiens	115-120
15341953-1	2004	A series of 2-(4-hydroxy-phenyl)-benzofuran-5-ols with relatively lipophilic groups in the 7-position of the benzofuran was prepared and the affinity and selectivity for ER beta was measured.	benzofuran	33-43	estrogen receptor 2	Homo sapiens	170-177
15177448-1	2004	Considering the recent challenge to the medicinal chemists for the development of selective melatonin receptor ligands, an attempt has been made to explore physicochemical requirements of benzofuran derivatives for binding with human MT1 and MT2 receptor subtypes and also to explore selectivity requirements.	benzofuran	188-198	metallothionein 1I, pseudogene	Homo sapiens	234-237
15177448-1	2004	Considering the recent challenge to the medicinal chemists for the development of selective melatonin receptor ligands, an attempt has been made to explore physicochemical requirements of benzofuran derivatives for binding with human MT1 and MT2 receptor subtypes and also to explore selectivity requirements.	benzofuran	188-198	metallothionein 2A	Homo sapiens	242-245
15177448-3	2004	The best equation describing MT1 binding affinity [n = 34, Q2 = 0.670, Ra2 = 0.790, R2 = 0.822, R = 0.907, s = 0.609, F = 25.8 (df 5, 28)] suggests that the binding affinity decreases as the value of n (number of CH2 spacer beside R2) increases while it increases with rise in electrotopological state values of different atoms of the benzofuran ring.	benzofuran	335-345	metallothionein 1I, pseudogene	Homo sapiens	29-32
12061881-4	2002	Introduction of a 2-phenyl substituent in the C-2 benzofuran position leads to an agonist compound, 10q, which binds more strongly than melatonin itself to both MT(1) and MT(2) subtypes.	benzofuran	50-60	complement C2	Homo sapiens	46-49
12234587-0	2002	Benzofuran derivatives as Abeta-aggregate-specific imaging agents for Alzheimer"s disease.	benzofuran	0-10	amyloid beta (A4) precursor protein	Mus musculus	26-31
12234587-8	2002	In conclusion, the benzofuran ligands displayed excellent binding affinity for Abeta aggregates.	benzofuran	19-29	amyloid beta (A4) precursor protein	Mus musculus	79-84
11983524-1	2002	3D-QSAR and molecular modeling was performed on a series of benzofuran/benzothiophene biphenyls as protein tyrosine phosphatase 1B (PTP 1B) inhibitors with anti-hyperglycemic activity.	benzofuran	60-70	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	99-130
11983524-1	2002	3D-QSAR and molecular modeling was performed on a series of benzofuran/benzothiophene biphenyls as protein tyrosine phosphatase 1B (PTP 1B) inhibitors with anti-hyperglycemic activity.	benzofuran	60-70	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	132-138
12878142-1	2003	A series of benzofuran antifungals was examined to determine the structural requirements of N-myristoyltransferase (Nmt) enzyme inhibition by three-dimensional quantitative structure-activity relationship (3D-QSAR) using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods.	benzofuran	12-22	N-myristoyltransferase 1	Homo sapiens	92-114
12878142-1	2003	A series of benzofuran antifungals was examined to determine the structural requirements of N-myristoyltransferase (Nmt) enzyme inhibition by three-dimensional quantitative structure-activity relationship (3D-QSAR) using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods.	benzofuran	12-22	N-myristoyltransferase 1	Homo sapiens	116-119
14578021-10	2002	Mice administered with combinations of nicotine and 5, 10 and 20 mg/kg doses of BZF (i.e. NP-5, NP10 and NP-20 groups), exhibited less intensity and severity of withdrawal effects compared to the mice treated with nicotine alone.	benzofuran	80-83	nuclear receptor subfamily 4, group A, member 1	Mus musculus	96-100
14578021-11	2002	Those mice treated with the two highest doses of BZF,in combination with nicotine (NP-10 and NP-20), showed significantly fewer nicotine-abstinence withdrawal jumps and normal ambulatory behaviour.	benzofuran	49-52	nuclear receptor subfamily 4, group A, member 1	Mus musculus	83-88
10956201-1	2000	In the course of our studies on retinoic acid receptor (RAR) agonists, we have designed and synthesized a series of benzofuran and benzothiophene derivatives.	benzofuran	116-126	retinoic acid receptor alpha	Homo sapiens	56-59
11992786-3	2002	Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257.	benzofuran	151-161	oxytocin/neurophysin I prepropeptide	Homo sapiens	76-84
11992786-4	2002	Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity.	benzofuran	48-58	oxytocin/neurophysin I prepropeptide	Homo sapiens	83-91
11809072-0	2002	A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex.	benzofuran	34-44	prolyl endopeptidase	Homo sapiens	2-22
11026543-0	2000	The conformation and activity relationship of benzofuran type of angiotensin II receptor antagonists.	benzofuran	46-56	angiotensinogen	Homo sapiens	65-79
11026543-1	2000	As a continuing effort to establish the structure and activity relationship in a benzofuran type of angiotensin II antagonist, we synthesized various regioisomers and performed a series of QSAR analyses.	benzofuran	81-91	angiotensinogen	Homo sapiens	100-114
10753467-0	2000	Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.	benzofuran	6-16	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	63-94
10753467-5	2000	We have identified two novel series of benzofuran/benzothiophene biphenyl oxo-acetic acids and sulfonyl-salicylic acids as potent inhibitors of PTP1B with good oral antihyperglycemic activity.	benzofuran	39-49	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	144-149
10428384-0	1999	Benzofuran based PDE4 inhibitors.	benzofuran	0-10	phosphodiesterase 4A	Homo sapiens	17-21
10229684-1	1999	A series of benzofuran derivatives have been identified as inhibitors of fibril formation in the beta-amyloid peptide.	benzofuran	12-22	amyloid beta precursor protein	Homo sapiens	97-117
10329215-6	1999	Conversely, the dose-dependent inhibitory effect of amiodarone, an iodinated benzofuran derivative that antagonizes thyroid hormone actions, on INa was blocked when myocytes were pretreated with T3(100 n m, n=3), suggesting an interaction of T3 with amiodarone.	benzofuran	77-87	internexin neuronal intermediate filament protein, alpha	Rattus norvegicus	144-147
10602306-3	1999	For both series of benzofuran-analogues and benzothiophene-analogues, an "odd/even" relationship between the position of an oxyanion on the aromatic ring relative to the attachment point to the dioxetane and the chemiluminescent properties, lambda(max), Phi(CL), and t(1/2), is observed, as in the case for dioxetanes bearing a phenolic or naphtholic substituent.	benzofuran	19-29	glucose-6-phosphate isomerase	Homo sapiens	254-257
9765337-1	1998	The benzofurane (+)-S 14297, the benzamide nafadotride, the aminoindane U 99194 and the arylpiperazine GR 103,691 have been proposed as "selective" antagonists at dopamine D3 vs. D2 receptors.	benzofuran	4-15	iodothyronine deiodinase 3	Homo sapiens	172-174
9353363-7	1997	Both delta-1 and delta-2 selective antagonists 7-benzylidenenaltrexone and a benzofuran analog of naltrindole displayed high affinity for the cloned receptor (0.04 and 0.08 nM) and antagonized the stimulation of [35S]GTPgammaS binding by BW373U86 and DPDPE with similar potencies.	benzofuran	77-87	delta like canonical Notch ligand 1	Rattus norvegicus	5-24
7473588-0	1995	Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.	benzofuran	93-103	selectin E	Homo sapiens	14-24
7473588-0	1995	Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.	benzofuran	93-103	intercellular adhesion molecule 1	Homo sapiens	27-33
7473588-0	1995	Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.	benzofuran	93-103	vascular cell adhesion molecule 1	Homo sapiens	40-46