PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21693154-3	2011	An increase in the binding of [(3)H]paroxetine to the SERT and [(3)H]GBR12935 to the DAT was observed in various brain regions of NET-KO mice, without alterations of mRNA encoding these transporters, as measured by in situ hybridization.	[(3)h]paroxetine	30-46	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	54-58
24022686-7	2013	Cell proliferation was measured with tetrazolium salts, and [(3)H]paroxetine was used as a SERT-specific ligand for binding assays.	[(3)h]paroxetine	60-76	solute carrier family 6 member 4	Rattus norvegicus	91-95
21693154-3	2011	An increase in the binding of [(3)H]paroxetine to the SERT and [(3)H]GBR12935 to the DAT was observed in various brain regions of NET-KO mice, without alterations of mRNA encoding these transporters, as measured by in situ hybridization.	[(3)h]paroxetine	30-46	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	85-88
21693154-3	2011	An increase in the binding of [(3)H]paroxetine to the SERT and [(3)H]GBR12935 to the DAT was observed in various brain regions of NET-KO mice, without alterations of mRNA encoding these transporters, as measured by in situ hybridization.	[(3)h]paroxetine	30-46	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	130-133
19189865-5	2009	Serotonin transporter was also labeled with [(3)H]paroxetine, specific binding defined with imipramine.	[(3)h]paroxetine	44-60	solute carrier family 6 member 4	Rattus norvegicus	0-21
19756361-6	2009	The tryptamines were also tested as inhibitors of [(3)H]paroxetine binding to the SERT and [(3)H]dihydrotetrabenazine binding to VMAT2.	[(3)h]paroxetine	50-66	solute carrier family 6 member 4	Homo sapiens	82-86
19756361-9	2009	On the other hand, the tryptamines were very poor inhibitors of [(3)H]paroxetine binding to SERT and of [(3)H]dihydrotetrabenazine binding to VMAT2, resulting in high binding-to-uptake ratios.	[(3)h]paroxetine	64-80	solute carrier family 6 member 4	Homo sapiens	92-96
17907785-4	2007	In the present study, we have systematically assessed the NADPH-dependent covalent binding of [(3)H]paroxetine to human liver microsomes and S-9 preparations in the absence and presence of cofactors of the various phase II drug-metabolizing enzymes involved in the downstream metabolism/detoxification of the putative paroxetine-catechol intermediate.	[(3)h]paroxetine	94-110	2,4-dienoyl-CoA reductase 1	Homo sapiens	58-63
18437564-3	2008	The aim of the present study was to study the in vivo effect of various antidepressants on [(3)H]paroxetine binding to SERT in regions of rat brain.	[(3)h]paroxetine	91-107	solute carrier family 6 member 4	Rattus norvegicus	119-123
18437564-7	2008	It was observed that the density of cortical SERT was significantly decreased with CMI (68%, P < 0.0001), FLX (67%, P < 0.0001), CIT (54%, P < 0.0001), and AMI (52%, P < 0.0001) treatment, when compared to the density of 120.7 +/- 4.0 fmol/mg protein in control rats, without altering the affinity (Kd) of [(3)H]paroxetine to the transporters.	[(3)h]paroxetine	318-334	solute carrier family 6 member 4	Rattus norvegicus	45-49
18437564-8	2008	The density of SERT in hippocampus was also significantly decreased with FLX (65%, P < 0.0001), CMI (54%, P < 0.0001), CIT (52%, P < 0.0001) and AMI (46%, P < 0.0001) treatment, when compared to the density of 74.0 +/- 2.6 fmol/mg protein in control rats, without altering the affinity of [(3)H]paroxetine to the transporters.	[(3)h]paroxetine	301-317	solute carrier family 6 member 4	Rattus norvegicus	15-19
17907785-4	2007	In the present study, we have systematically assessed the NADPH-dependent covalent binding of [(3)H]paroxetine to human liver microsomes and S-9 preparations in the absence and presence of cofactors of the various phase II drug-metabolizing enzymes involved in the downstream metabolism/detoxification of the putative paroxetine-catechol intermediate.	[(3)h]paroxetine	94-110	ribosomal protein S9	Homo sapiens	141-144
17907785-5	2007	Incubation of [(3)H]paroxetine with human liver microsomes and S-9 preparations resulted in irreversible binding of radioactive material to macromolecules by a process that was NADPH-dependent.	[(3)h]paroxetine	14-30	ribosomal protein S9	Homo sapiens	63-66
17907785-5	2007	Incubation of [(3)H]paroxetine with human liver microsomes and S-9 preparations resulted in irreversible binding of radioactive material to macromolecules by a process that was NADPH-dependent.	[(3)h]paroxetine	14-30	2,4-dienoyl-CoA reductase 1	Homo sapiens	177-182
17907785-12	2007	Inclusion of the catechol-O-methyltransferase cofactor S-adenosylmethionine (SAM) in S-9 incubations also dramatically reduced the covalent binding of [(3)H]paroxetine, a finding that was consistent with O-methylation of the paroxetine-catechol metabolite to the corresponding guaiacol regioisomers in S-9 incubations.	[(3)h]paroxetine	151-167	catechol-O-methyltransferase	Homo sapiens	17-45
17907785-12	2007	Inclusion of the catechol-O-methyltransferase cofactor S-adenosylmethionine (SAM) in S-9 incubations also dramatically reduced the covalent binding of [(3)H]paroxetine, a finding that was consistent with O-methylation of the paroxetine-catechol metabolite to the corresponding guaiacol regioisomers in S-9 incubations.	[(3)h]paroxetine	151-167	ribosomal protein S9	Homo sapiens	85-88
17907785-12	2007	Inclusion of the catechol-O-methyltransferase cofactor S-adenosylmethionine (SAM) in S-9 incubations also dramatically reduced the covalent binding of [(3)H]paroxetine, a finding that was consistent with O-methylation of the paroxetine-catechol metabolite to the corresponding guaiacol regioisomers in S-9 incubations.	[(3)h]paroxetine	151-167	ribosomal protein S9	Homo sapiens	302-305
15380396-3	2004	In the present study, platelet serotonin transporter (SERT) binding was assessed using [(3)H]paroxetine in 14 depressed pregnant women, 31 normal healthy pregnant women, 39 depressed postpartum women, and 27 normal healthy postpartum women; all of the subjects were drug-free.	[(3)h]paroxetine	87-103	solute carrier family 6 member 4	Homo sapiens	31-52
16166809-1	2005	Serotonin transporter, measured by the specific binding of [(3)H]paroxetine, has been reported to be reduced in circulating lymphocytes of patients with major depression.	[(3)h]paroxetine	59-75	solute carrier family 6 member 4	Homo sapiens	0-21
15380396-3	2004	In the present study, platelet serotonin transporter (SERT) binding was assessed using [(3)H]paroxetine in 14 depressed pregnant women, 31 normal healthy pregnant women, 39 depressed postpartum women, and 27 normal healthy postpartum women; all of the subjects were drug-free.	[(3)h]paroxetine	87-103	solute carrier family 6 member 4	Homo sapiens	54-58
14687821-3	2003	METHODS: Binding of [(3)H]paroxetine to SERT was assayed in platelet membranes collected from D-IBS patients (12 women, age 21-73 yr) and healthy volunteers (12 women, age 24-68 yr).	[(3)h]paroxetine	20-36	solute carrier family 6 member 4	Homo sapiens	40-44
12849931-3	2003	The specific binding of [(3)H]paroxetine to serotonin transporter (SERT) and of [(3)H]lazabemide to monoamine oxidase (MAO-B) were measured autoradiographically in tissue sections cut transversely at multiple levels along the rostro-caudal extent of the LC, as well as in the caudal portion of the dorsal raphe nucleus, from psychiatrically normal subjects and age-matched subjects with major depression.	[(3)h]paroxetine	24-40	solute carrier family 6 member 4	Homo sapiens	44-65
12849931-4	2003	Under the conditions of the assays, [(3)H]paroxetine binding in the LC was specific for the SERT, based on the rank order of affinity of compounds for inhibiting [(3)H]paroxetine binding in the LC, i.e. citalopram > imipramine > desipramine > mazindol.	[(3)h]paroxetine	36-52	solute carrier family 6 member 4	Homo sapiens	92-96
12849931-4	2003	Under the conditions of the assays, [(3)H]paroxetine binding in the LC was specific for the SERT, based on the rank order of affinity of compounds for inhibiting [(3)H]paroxetine binding in the LC, i.e. citalopram > imipramine > desipramine > mazindol.	[(3)h]paroxetine	162-178	solute carrier family 6 member 4	Homo sapiens	92-96
12849931-5	2003	The binding of [(3)H]paroxetine to SERT and [(3)H]lazabemide to MAO-B were higher in the raphe nuclei than in the LC.	[(3)h]paroxetine	15-31	solute carrier family 6 member 4	Homo sapiens	35-39
12849931-5	2003	The binding of [(3)H]paroxetine to SERT and [(3)H]lazabemide to MAO-B were higher in the raphe nuclei than in the LC.	[(3)h]paroxetine	15-31	monoamine oxidase B	Homo sapiens	64-69