PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 21795682-4 2011 We present here biophysical and biochemical studies that have enabled us to characterize the interaction of metal-substituted, tetrasulfonated phthalocyanines (PcTS) with alpha-synuclein (AS), the major protein component of amyloid-like deposits in Parkinson disease. Polychloroterphenyl Compounds 160-164 synuclein alpha Homo sapiens 171-186 21880518-8 2011 Even though the variation in porphyric response did not parallel the hepatic iron concentration, the results are compatible with the presence of a Cyp1a2-independent, iron-dependent pathway for the generation of uroporphomethene, the UROD inhibitor required for the expression of uroporphyria in mice and PCT in humans. Polychloroterphenyl Compounds 305-308 uroporphyrinogen decarboxylase Mus musculus 234-238 21795682-4 2011 We present here biophysical and biochemical studies that have enabled us to characterize the interaction of metal-substituted, tetrasulfonated phthalocyanines (PcTS) with alpha-synuclein (AS), the major protein component of amyloid-like deposits in Parkinson disease. Polychloroterphenyl Compounds 160-164 long intergenic non-protein coding RNA 2605 Homo sapiens 188-190 21795682-5 2011 The inhibitory activity of the assayed compounds on AS amyloid fibril formation decreases in the order PcTS[Ni(II)] ~ PcTS > PcTS[Zn(II)] >> PcTS[Al(III)] 0. Polychloroterphenyl Compounds 103-107 long intergenic non-protein coding RNA 2605 Homo sapiens 52-54 21795682-5 2011 The inhibitory activity of the assayed compounds on AS amyloid fibril formation decreases in the order PcTS[Ni(II)] ~ PcTS > PcTS[Zn(II)] >> PcTS[Al(III)] 0. Polychloroterphenyl Compounds 118-122 long intergenic non-protein coding RNA 2605 Homo sapiens 52-54 21795682-5 2011 The inhibitory activity of the assayed compounds on AS amyloid fibril formation decreases in the order PcTS[Ni(II)] ~ PcTS > PcTS[Zn(II)] >> PcTS[Al(III)] 0. Polychloroterphenyl Compounds 118-122 long intergenic non-protein coding RNA 2605 Homo sapiens 52-54 21795682-5 2011 The inhibitory activity of the assayed compounds on AS amyloid fibril formation decreases in the order PcTS[Ni(II)] ~ PcTS > PcTS[Zn(II)] >> PcTS[Al(III)] 0. Polychloroterphenyl Compounds 118-122 long intergenic non-protein coding RNA 2605 Homo sapiens 52-54 16130654-4 2005 For the DB-1 x HT-8 column combination, the useful principle of congener separation on the basis of number of halogen substituents in a molecule was confirmed (PCBs, toxaphene) and extended (PCTs, PBDEs). Polychloroterphenyl Compounds 191-195 vascular endothelial zinc finger 1 Homo sapiens 8-12 34348084-6 2021 Interestingly, PCT induced DNA damage, the resulting autophagosome, the accumulation of Beclin-1, the reduction of p62, the translocation and the formation of LC3-II. Polychloroterphenyl Compounds 15-18 beclin 1, autophagy related Mus musculus 88-96 10807595-5 2000 The lipoxygenase metabolite 12(S)-hydroxyeicosatetraenoic acid (HETE) and the cytochrome P-450 metabolite 20-HETE both inhibited PCT Na(+)-K(+)-ATPase in a protein kinase C-dependent manner, but the effect was significantly more pronounced in infant PCT. Polychloroterphenyl Compounds 129-132 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-94 15008976-6 2004 The presence of LPS did not modify PCT-233-stimulated TNF production, but the ratio TNF/IL-10 production by LPS-stimulated AM was reduced significantly in the presence of PCT-233. Polychloroterphenyl Compounds 171-174 tumor necrosis factor Homo sapiens 84-87 15008976-6 2004 The presence of LPS did not modify PCT-233-stimulated TNF production, but the ratio TNF/IL-10 production by LPS-stimulated AM was reduced significantly in the presence of PCT-233. Polychloroterphenyl Compounds 171-174 interleukin 10 Homo sapiens 88-93 15008976-9 2004 Interestingly, AM treatment with PCT-233 and budesonide 18 h after LPS stimulation did not modulate TNF release significantly but it did increase IL-10 production, and a synergistic effect was observed with the combination PCT-233/budesonide. Polychloroterphenyl Compounds 33-36 interleukin 10 Homo sapiens 146-151 11202050-10 2000 Some genetic prerequisites for susceptibility to PCT-inducing agents are included in a tentative model for the disease, i.e. mutations in the UPGD gene and in the HFE gene affected in haemochromatosis, as well as genetically steered inducibilities of the genes programming for CYP4501A and the rate-limiting enzyme in haem synthesis, 5-aminolevulinate synthase. Polychloroterphenyl Compounds 49-52 uroporphyrinogen decarboxylase Homo sapiens 142-146 11202050-10 2000 Some genetic prerequisites for susceptibility to PCT-inducing agents are included in a tentative model for the disease, i.e. mutations in the UPGD gene and in the HFE gene affected in haemochromatosis, as well as genetically steered inducibilities of the genes programming for CYP4501A and the rate-limiting enzyme in haem synthesis, 5-aminolevulinate synthase. Polychloroterphenyl Compounds 49-52 homeostatic iron regulator Homo sapiens 163-166 34348084-6 2021 Interestingly, PCT induced DNA damage, the resulting autophagosome, the accumulation of Beclin-1, the reduction of p62, the translocation and the formation of LC3-II. Polychloroterphenyl Compounds 15-18 nucleoporin 62 Mus musculus 115-118 34348084-8 2021 Furthermore, PCT treatment group significantly enhanced the phosphorylation level of AMPK, decreased the mTOR and p70s6k phosphorylation levels and activated the AMPK/mTOR signaling pathway in RAW264.7 cells. Polychloroterphenyl Compounds 13-16 mechanistic target of rapamycin kinase Mus musculus 105-109 34348084-8 2021 Furthermore, PCT treatment group significantly enhanced the phosphorylation level of AMPK, decreased the mTOR and p70s6k phosphorylation levels and activated the AMPK/mTOR signaling pathway in RAW264.7 cells. Polychloroterphenyl Compounds 13-16 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 114-120 34348084-8 2021 Furthermore, PCT treatment group significantly enhanced the phosphorylation level of AMPK, decreased the mTOR and p70s6k phosphorylation levels and activated the AMPK/mTOR signaling pathway in RAW264.7 cells. Polychloroterphenyl Compounds 13-16 mechanistic target of rapamycin kinase Mus musculus 167-171 30522129-4 2018 METHODS AND FINDINGS: We use the individual-based transmission model WORMSIM to predict the short and long-term impact of WASH on STH transmission in contexts with and without PCT. Polychloroterphenyl Compounds 176-179 saitohin Homo sapiens 130-133 3327428-9 1987 In contrast, exposure to dioxin on the part of persons with inherited uroporphyrinogen decarboxylase deficiency can cause latent chronic hepatic porphyria to develop into PCT. Polychloroterphenyl Compounds 171-174 uroporphyrinogen decarboxylase Homo sapiens 70-100 3936957-2 1985 The intraperitoneal administration of PCT and SCT inhibited gastric acid secretion stimulated by thyrotropin-releasing hormone (TRH) and 2-deoxy-D-glucose, but neither bethanechol nor tetragastrin. Polychloroterphenyl Compounds 38-41 thyrotropin releasing hormone Rattus norvegicus 97-126 3936957-2 1985 The intraperitoneal administration of PCT and SCT inhibited gastric acid secretion stimulated by thyrotropin-releasing hormone (TRH) and 2-deoxy-D-glucose, but neither bethanechol nor tetragastrin. Polychloroterphenyl Compounds 38-41 thyrotropin releasing hormone Rattus norvegicus 128-131 30995970-10 2019 Mean [95% CI] percentage change (%Delta) in CCT was 1.2% [0.9%, 1.5%], 1.2% [0.9%, 1.4%], and 0.8% [0.6%, 1.1%] for CCT, nasal PCT, and temporal PCT, respectively. Polychloroterphenyl Compounds 127-130 CCT Homo sapiens 44-47 29027523-9 2017 The detection of the higher production of the extracellular matrix tenascin C participating in the formation of the TSC niche fully combined with the CD44+/CD24low/- phenotype; while the maximum response to tenascin C was noted in the cases differing in not only a lack of responses to PCTs, but also in the most aggressive course in conjunction with metastatic disease. Polychloroterphenyl Compounds 286-290 tenascin C Homo sapiens 67-75 28471235-10 2017 PCT and DCT showed less PAS reaction and more COX-2 and caspase expression if compared with the control and the GSE groups. Polychloroterphenyl Compounds 0-3 cytochrome c oxidase II, mitochondrial Rattus norvegicus 46-51