PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25311421-13	2014	Two of the new piperaquine phosphate related substances, imp-2 and imp-6, were identified and characterized as 4-hydroxy-7-chloro-quinoline and a piperaquine oxygenate with a piperazine ring of nitrogen oxide in bulk drug and oxidation sample, respectively.	Nitrogen Oxides	194-208	inositol monophosphatase 2	Homo sapiens	57-62
23357567-8	2013	PC2 and PC3 cluster American- and Virginia-blends, revealing inverse correlations: Nitrogen oxides and amino- or nitroso-aromatic compounds inversely correlate to either formaldehyde and acrolein, or benzo(a)pyrene and di-hydroxybenzenes.	Nitrogen Oxides	83-98	chromobox 4	Homo sapiens	0-3
25286572-4	2014	Nitrogen oxide (NO) is continuously produced in humans and animals involving enzymatic NO-synthase (NOS), acting as a universal regulator of diverse biological and physiological processes.	Nitrogen Oxides	0-14	nitric oxide synthase 2	Homo sapiens	87-98
24534699-7	2014	The NPAHs associated with PM1 were correlated with the pollutants nitrogen oxides and NPAHs with meteorological variables: temperature and wind speed.	Nitrogen Oxides	66-81	transmembrane protein 11	Homo sapiens	26-29
25306593-6	2014	IFN alpha and gamma increased synthesis of nitrogen oxides and reduced the synthesis of endothelin-1, while IFN beta activated the production of endothelin-1.	Nitrogen Oxides	43-58	interferon alpha 1	Homo sapiens	0-9
24049059-9	2013	Our studies support the hypothesis that ( )NO oxidative chemistry can detoxify VP-16 through direct nitrogen oxide radical attack.	Nitrogen Oxides	100-114	host cell factor C1	Homo sapiens	79-84
23387982-1	2013	In the atmosphere, mineral dust particles are often associated with adsorbed nitrate from heterogeneous reactions with nitrogen oxides (N2O5, HNO3, NO3, and NO2).	Nitrogen Oxides	119-134	NBL1, DAN family BMP antagonist	Homo sapiens	143-146
23402364-6	2013	Separation and spectral analysis of VP-16 reaction extracts by electron spin resonance and UV-vis indicated the generation of the phenoxy radical and the o-quinone of VP-16, as well as putative nitroxide, iminoxyl, and other nitrogen oxide intermediates.	Nitrogen Oxides	225-239	host cell factor C1	Homo sapiens	36-41
22219348-7	2012	When pollutants were analyzed separately, the IRR for hypertension for a 10-mug/m(3) increase in PM(2.5) was 1.48 (95% CI, 0.95-2.31), and the IRR for the interquartile range (12.4 parts per billion) of nitrogen oxides was 1.14 (95% CI, 1.03-1.25).	Nitrogen Oxides	203-218	insulin receptor related receptor	Homo sapiens	46-49
22878412-5	2012	In Sftpd(-/-) mice, but not Sftpd(+/+) mice, increased BAL protein and nitrogen oxides were observed after ozone inhalation, indicating prolonged lung injury and oxidative stress.	Nitrogen Oxides	71-86	surfactant associated protein D	Mus musculus	3-8
22702952-0	2012	Zinc thiolate reactivity toward nitrogen oxides: insights into the interaction of Zn2+ with S-nitrosothiols and implications for nitric oxide synthase.	Nitrogen Oxides	32-47	nitric oxide synthase 2	Homo sapiens	129-150
21227886-6	2011	RESULTS: For the highest compared with the lowest quartile of NOx concentration at the residence, we found an IRR for lung cancer of 1.30 [95% confidence interval (CI), 1.05-1.61], and the IRR for lung cancer in association with living within 50 m of a major road (>10,000 vehicles/day) was 1.21 (95% CI, 0.95-1.55).	Nitrogen Oxides	62-65	insulin receptor related receptor	Homo sapiens	110-113
21227886-6	2011	RESULTS: For the highest compared with the lowest quartile of NOx concentration at the residence, we found an IRR for lung cancer of 1.30 [95% confidence interval (CI), 1.05-1.61], and the IRR for lung cancer in association with living within 50 m of a major road (>10,000 vehicles/day) was 1.21 (95% CI, 0.95-1.55).	Nitrogen Oxides	62-65	insulin receptor related receptor	Homo sapiens	189-192
21045638-3	2010	Recently, an alternative pathway for nitric oxide generation was discovered, wherein the inorganic anions nitrate (NO3) and nitrite (NO2), most often considered inert end products from nitric oxide generation, can be reduced back to nitric oxide and other bioactive nitrogen oxide species.	Nitrogen Oxides	266-280	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
21212274-2	2011	However, little is known about the regulation of the two other p53-family members, p63 and p73, by nitrogen oxides.	Nitrogen Oxides	99-114	tumor protein p53	Homo sapiens	63-66
21212274-2	2011	However, little is known about the regulation of the two other p53-family members, p63 and p73, by nitrogen oxides.	Nitrogen Oxides	99-114	tumor protein p63	Homo sapiens	83-86
21212274-2	2011	However, little is known about the regulation of the two other p53-family members, p63 and p73, by nitrogen oxides.	Nitrogen Oxides	99-114	tumor protein p73	Homo sapiens	91-94
20568506-1	2010	The activity of inducible synthase of nitrogen oxide (iNOS) and its modulators in vitro, while stimulation by lipopolysaccharides (LPS), was investigated in 36 patients with diabetic foot syndrome for the objective of complex estimation of monocytic functional state and its role in regulation of the cutaneous wound healing.	Nitrogen Oxides	38-52	inositol-3-phosphate synthase 1	Homo sapiens	54-58
20675541-0	2010	Keeping the heart in balance: the functional interactions of myoglobin with nitrogen oxides.	Nitrogen Oxides	76-91	myoglobin	Mus musculus	61-70
20586447-11	2010	The simulations showed that NO3 trends and concentrations were influenced mainly by changes in ozone and nitrogen oxide levels and that the very high levels of NO3 can be explained by the entrainment of fresh ozone from the upper atmospheric levels.	Nitrogen Oxides	105-119	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
20585450-4	2010	PRINCIPAL FINDINGS: Exposure of skeletal and cardiac myosins to physiological concentrations of nitrogen oxides, including the endogenous nitrosothiol S-nitroso-L-cysteine, reduced the velocity of actin filaments over myosin in a dose-dependent and oxygen-dependent manner, caused a doubling of force as measured in a laser trap transducer, and caused S-nitrosylation of cysteines in the myosin heavy chain.	Nitrogen Oxides	96-111	myosin heavy chain 14	Homo sapiens	53-59
20585450-4	2010	PRINCIPAL FINDINGS: Exposure of skeletal and cardiac myosins to physiological concentrations of nitrogen oxides, including the endogenous nitrosothiol S-nitroso-L-cysteine, reduced the velocity of actin filaments over myosin in a dose-dependent and oxygen-dependent manner, caused a doubling of force as measured in a laser trap transducer, and caused S-nitrosylation of cysteines in the myosin heavy chain.	Nitrogen Oxides	96-111	myosin heavy chain 14	Homo sapiens	218-224
20335404-11	2010	Z-ISO evolved from an ancestor related to the NnrU (for nitrite and nitric oxide reductase U) gene required for bacterial denitrification, a pathway that produces nitrogen oxides as alternate electron acceptors for anaerobic growth.	Nitrogen Oxides	163-178	15-cis-zeta-carotene isomerase	Arabidopsis thaliana	0-5
20675541-6	2010	As Mb is widespread throughout the fauna, the diverse oxygen-dependent interactions between Mb and nitrogen oxides may not only be of relevance for mammals but also for other vertebrates as evidenced by comparable phenotypes of "artificial" (myo(-/-) mice) and "natural" Mb knockouts (icefish and amphibians).	Nitrogen Oxides	99-114	myoglobin	Mus musculus	3-5
20138493-8	2010	A significantly higher concentration of nitrogen oxide (muM) was seen in ventilated patients vs controls (66.22 [22.26-83.13] vs 15.06 [10.73-23.30]; P=0.002), whereas levels of 8-isoprostane (pg/mL) were not significantly different between both groups (5.73 [4.0-11.4] vs 9.09 [6.63-11.43]; P=0.169).	Nitrogen Oxides	40-54	latexin	Homo sapiens	56-59
29116921-9	2009	The concentrations of CO2 and NOx from B10 were quite similar to those from diesel.	Nitrogen Oxides	30-33	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	39-42
19745228-5	2009	BNIP3 expression is also regulated by other factors, such as E2F-1, NF-kappaB, and Rb during hypoxia and nitrogen oxide during normoxia.	Nitrogen Oxides	105-119	BCL2 interacting protein 3	Homo sapiens	0-5
19264798-4	2009	In a previously published computational study of nitrogen oxide metabolism in bacteria, a small number of amino-acid residues were found to determine the specificity within the CRP (cAMP receptor protein)/FNR (fumarate and nitrate reductase regulatory protein) family of transcription factors.	Nitrogen Oxides	49-63	catabolite gene activator protein	Escherichia coli	177-180
19264798-4	2009	In a previously published computational study of nitrogen oxide metabolism in bacteria, a small number of amino-acid residues were found to determine the specificity within the CRP (cAMP receptor protein)/FNR (fumarate and nitrate reductase regulatory protein) family of transcription factors.	Nitrogen Oxides	49-63	catabolite gene activator protein	Escherichia coli	182-203
18931948-5	2009	We aim to study a possible benefit of a common nitrogen oxide donor, anti-anginal drug, nicorandil [N-(2-hydroxyethyl) nicotinamide nitrate ester], in managing acute gastric ulcers through studying its effect on some relevant intermediates to ulcerogenesis as lipid peroxidation, tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO).	Nitrogen Oxides	47-61	tumor necrosis factor	Homo sapiens	280-307
18931948-5	2009	We aim to study a possible benefit of a common nitrogen oxide donor, anti-anginal drug, nicorandil [N-(2-hydroxyethyl) nicotinamide nitrate ester], in managing acute gastric ulcers through studying its effect on some relevant intermediates to ulcerogenesis as lipid peroxidation, tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO).	Nitrogen Oxides	47-61	tumor necrosis factor	Homo sapiens	309-318
18796497-0	2008	Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production.	Nitrogen Oxides	8-22	nitric oxide synthase 2	Homo sapiens	105-109
18796497-0	2008	Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production.	Nitrogen Oxides	8-22	matrix metallopeptidase 2	Homo sapiens	119-124
15571391-6	2004	The interconversion among the various oxidation states of myoglobin that is prompted by nitrogen oxide species is remarkable.	Nitrogen Oxides	88-102	myoglobin	Homo sapiens	58-67
17979338-0	2007	Ab initio calculations of nitrogen oxide reactions: formation of N2O2, N2O3, N2O4, N2O5, and N4O2 from NO, NO2, NO3, and N2O.	Nitrogen Oxides	26-40	NBL1, DAN family BMP antagonist	Homo sapiens	112-115
17099031-0	2006	Heterozygotes of NOS3 polymorphisms contribute to reduced nitrogen oxides in high-altitude pulmonary edema.	Nitrogen Oxides	58-73	nitric oxide synthase 3	Homo sapiens	17-21
16648189-11	2006	The negative feedback mechanism on ET(B2) subsides during hypotension, and the ensuing vasoconstriction is ascribed to ET-1 activating ET(A) and ET(B2) and reactive nitrogen oxide species originating from ROS-NO interaction.	Nitrogen Oxides	165-179	endothelin 1	Homo sapiens	119-123
16910783-0	2006	The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling.	Nitrogen Oxides	118-132	nitric oxide synthase 2	Homo sapiens	33-54
16424150-3	2006	The nitrate moiety of this latter is subsequently metabolized to inorganic nitrogen oxides (NOx), predominantly in liver cytosol by glutathione S-transferase (GST) and to a lesser extent in liver mitochondria.	Nitrogen Oxides	75-90	glutathione S-transferase kappa 1	Homo sapiens	132-157
16424150-3	2006	The nitrate moiety of this latter is subsequently metabolized to inorganic nitrogen oxides (NOx), predominantly in liver cytosol by glutathione S-transferase (GST) and to a lesser extent in liver mitochondria.	Nitrogen Oxides	75-90	glutathione S-transferase kappa 1	Homo sapiens	159-162
16424150-3	2006	The nitrate moiety of this latter is subsequently metabolized to inorganic nitrogen oxides (NOx), predominantly in liver cytosol by glutathione S-transferase (GST) and to a lesser extent in liver mitochondria.	Nitrogen Oxides	92-95	glutathione S-transferase kappa 1	Homo sapiens	132-157
16424150-3	2006	The nitrate moiety of this latter is subsequently metabolized to inorganic nitrogen oxides (NOx), predominantly in liver cytosol by glutathione S-transferase (GST) and to a lesser extent in liver mitochondria.	Nitrogen Oxides	92-95	glutathione S-transferase kappa 1	Homo sapiens	159-162
16689096-2	2006	It was established that an incubation of tissues with nitrogen oxide donator results in an increase of nitrits" level, some intensification of LPO and activation of antioxidant defense enzymes, especially in rats with SAH.	Nitrogen Oxides	54-68	lactoperoxidase	Rattus norvegicus	143-146
16646288-8	2006	In all cases fasting nitrogen oxide concentration measured indirectly by the level of nitrites (NO2-) and nitrates (NO3-) (micromol/L); triglycerides, total cholesterol, LDL and HDL cholesterol (mmol/L) were assessed.	Nitrogen Oxides	21-35	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
18044519-5	2007	Nitrogen oxide (NO) is shown to reduce aerosol formation; the constant aerosol formation rate obtained before addition of NO and after consumption of NO strongly suggests that aerosol formation is mainlythrough reactions with OH and HO2 radicals.	Nitrogen Oxides	0-14	heme oxygenase 2	Homo sapiens	233-236
16041517-0	2005	Gaseous nitrogen oxide repressed benzo[a]pyrene-induced human lung fibroblast cell apoptosis via inhibiting JNK1 signals.	Nitrogen Oxides	8-22	mitogen-activated protein kinase 8	Homo sapiens	108-112
14732341-13	2003	Our results provide the first evidence that formaldehyde dehydrogenase-dependent decomposition of S-nitrosoglutathione plays a role in protecting against nitrogen oxide-mediated protein S-nitrosation.	Nitrogen Oxides	154-168	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	44-70
14638548-7	2003	In the hDDAH-1 transgenic mice, we observed approximately 2-fold increases in tissue NOS activity and urinary nitrogen oxides, associated with a 2-fold reduction in plasma ADMA.	Nitrogen Oxides	110-125	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	7-14
15448086-2	2004	EUK-8 is a member of a new class of synthetic salen-manganese compounds with low toxicity that possess catalytic superoxide dismutase, peroxidase, and catalase activity that can inactivate superoxide and nitrogen oxides (e.g., peroxynitrite and nitrogen dioxide).	Nitrogen Oxides	204-219	catalase	Mus musculus	151-159
15208873-4	2004	Besides, an application of I-ACE reduces angiotensin II formation and activates renin-kallicrein-kinin system resulting in nitrogen oxide formation that is in its turn an important component of reparative process of mucous of gastrointestinal tract.	Nitrogen Oxides	123-137	renin	Homo sapiens	80-85
14697220-6	2004	The PTD-FNK protein protected chondrocytes from cell death induced by Fas antibody and nitrogen oxide (NO).	Nitrogen Oxides	87-101	polo like kinase 3	Homo sapiens	8-11
14658904-0	2003	Interaction of nitrogen oxides with sublimed layers of (meso-tetraphenylporphyrinato)cobalt(II); IR evidence of oxo-transfer from (nitro)porphyrinatocobalt(III) to free nitric oxide.	Nitrogen Oxides	15-30	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	156-159
12364556-1	2002	In this study, we investigated the effects of various nitrogen oxide (NO(x)) species on the extent of prostaglandin H(2) synthase-1 (PGHS-1) nitration in purified protein and in vascular smooth muscle cells.	Nitrogen Oxides	54-68	prostaglandin-endoperoxide synthase 1	Homo sapiens	102-131
12970573-0	2003	Gaseous nitrogen oxides stimulate cell cycle progression by retinoblastoma phosphorylation via activation of cyclins/Cdks [correction].	Nitrogen Oxides	8-23	RB transcriptional corepressor 1	Homo sapiens	60-74
12970573-4	2003	In this study we show that NOx gas stimulates MRC-5 cell proliferation by retinoblastoma (Rb) phosphorylation via activation of cyclin-cell division protein kinase (cdk) complexes [correction].	Nitrogen Oxides	27-30	RB transcriptional corepressor 1	Homo sapiens	74-88
12970573-4	2003	In this study we show that NOx gas stimulates MRC-5 cell proliferation by retinoblastoma (Rb) phosphorylation via activation of cyclin-cell division protein kinase (cdk) complexes [correction].	Nitrogen Oxides	27-30	RB transcriptional corepressor 1	Homo sapiens	90-92
12970573-7	2003	These data suggested that NOx gas stimulates cell-cycle progression by Rb phosphorylation via activation of cyclin-cdk complexes and inhibition of CKIs.	Nitrogen Oxides	26-29	RB transcriptional corepressor 1	Homo sapiens	71-73
12712605-4	2003	Studied in the above patients were blood serum content of nitrogen oxide by determining levels of its stable metabolites NO2- and NO3- anions.	Nitrogen Oxides	58-72	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
12364556-1	2002	In this study, we investigated the effects of various nitrogen oxide (NO(x)) species on the extent of prostaglandin H(2) synthase-1 (PGHS-1) nitration in purified protein and in vascular smooth muscle cells.	Nitrogen Oxides	54-68	prostaglandin-endoperoxide synthase 1	Homo sapiens	133-139
12079429-0	2002	Induced proliferation of human MRC-5 cells by nitrogen oxides via direct and indirect activation of MEKK1, JNK, and p38 signals.	Nitrogen Oxides	46-61	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	100-105
12079429-0	2002	Induced proliferation of human MRC-5 cells by nitrogen oxides via direct and indirect activation of MEKK1, JNK, and p38 signals.	Nitrogen Oxides	46-61	mitogen-activated protein kinase 8	Homo sapiens	107-110
12079429-0	2002	Induced proliferation of human MRC-5 cells by nitrogen oxides via direct and indirect activation of MEKK1, JNK, and p38 signals.	Nitrogen Oxides	46-61	mitogen-activated protein kinase 14	Homo sapiens	116-119
12079429-8	2002	Therefore, the NOx-induced cell proliferation via activation of MEKK1, JNK1, and p38 might contribute to lung tissue damage caused by NOx pollutants.	Nitrogen Oxides	15-18	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	64-69
12079429-8	2002	Therefore, the NOx-induced cell proliferation via activation of MEKK1, JNK1, and p38 might contribute to lung tissue damage caused by NOx pollutants.	Nitrogen Oxides	15-18	mitogen-activated protein kinase 8	Homo sapiens	71-75
12079429-8	2002	Therefore, the NOx-induced cell proliferation via activation of MEKK1, JNK1, and p38 might contribute to lung tissue damage caused by NOx pollutants.	Nitrogen Oxides	15-18	mitogen-activated protein kinase 14	Homo sapiens	81-84
11976082-5	2002	An isolate of 2.4.1 carrying a copy of the nitrite reductase gene from 2.4.3 showed a taxis response to both nitrogen oxides.	Nitrogen Oxides	109-124	AWN88_RS06525	Agrobacterium tumefaciens	43-60
12067508-10	2002	Unitary emission conversion coefficients of nitrogen oxide in a static test ECE R49 were determined.	Nitrogen Oxides	44-58	endothelin converting enzyme 1	Homo sapiens	76-79
12716289-0	2002	Reactive Oxygen and Nitrogen Oxide Species-induced Stress, a Major Intrinsic Factor Involved in Carcinogenic Processes and a Possible Target for Cancer Prevention.	Nitrogen Oxides	20-34	cobalamin binding intrinsic factor	Homo sapiens	67-83
12716289-2	2002	For multistage carcinogenic processes, reactive oxygen and nitrogen oxide species-induced stress (RONOSS) serves as a major intrinsic factor and is involved in every step.	Nitrogen Oxides	59-73	cobalamin binding intrinsic factor	Homo sapiens	124-140
11743740-5	2001	The nitrosating nitrogen oxide species N(2)O(3) is likely to be the disrupter of Ace1 activity.	Nitrogen Oxides	16-30	Cup2p	Saccharomyces cerevisiae S288C	81-85
11743740-0	2001	Mechanisms of nitrogen oxide-mediated disruption of metalloprotein function: an examination of the copper-responsive yeast transcription factor Ace1.	Nitrogen Oxides	14-28	Cup2p	Saccharomyces cerevisiae S288C	144-148
11689476-2	2001	Higher NO concentrations, as synthesized by the inducible NO synthase (iNOS) during inflammatory processes, show additional effects: NO may react with O2, yielding nitrogen oxides like N2O3 that are able to nitrosate thiols.	Nitrogen Oxides	164-179	nitric oxide synthase 2	Homo sapiens	48-69
11743740-3	2001	In the present study, the chemical interaction of nitrogen oxide species with Ace1 was examined using a yeast reporter system.	Nitrogen Oxides	50-64	Cup2p	Saccharomyces cerevisiae S288C	78-82
11743740-4	2001	Exposure of yeast to various nitrogen oxides, under a variety of conditions, revealed that the oxygen-dependent inhibition of Ace1 is due to the reaction of NO with O(2).	Nitrogen Oxides	29-44	Cup2p	Saccharomyces cerevisiae S288C	126-130
11689476-2	2001	Higher NO concentrations, as synthesized by the inducible NO synthase (iNOS) during inflammatory processes, show additional effects: NO may react with O2, yielding nitrogen oxides like N2O3 that are able to nitrosate thiols.	Nitrogen Oxides	164-179	nitric oxide synthase 2	Homo sapiens	71-75
10518791-4	1999	Using gamma-irradiation methods, we characterized the products formed by these nitrogen oxides with angiotensin II.	Nitrogen Oxides	79-94	angiotensinogen	Homo sapiens	100-114
11434166-3	2001	In all cases nitrogen oxide concentration was designated in supernatant of 48 hours leukocytes culture with using colorimetric method with Griess reagent described by Ding.	Nitrogen Oxides	13-27	ring finger protein 2	Homo sapiens	167-171
11093754-0	2000	Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides.	Nitrogen Oxides	104-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	26-52
11106932-6	2000	iNOS produces an excessive amount of NO for long periods, which allows generation of a highly reactive nitrogen oxide species, peroxynitrite, via a radical coupling reaction of NO with superoxide.	Nitrogen Oxides	103-117	nitric oxide synthase 2, inducible	Mus musculus	0-4
9406243-1	1997	DT-diaphorase (EC 1.6.99.2) is a flavoprotein that catalyses two-electron reduction of quinones, quinone imines, and nitrogen oxides.	Nitrogen Oxides	117-132	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-13
9612571-3	1998	It was shown that TRAP increases the concentration of Ca2+ in the cytoplasm of mast cells and regulates cell degranulation, while releasing nitrogen oxide.	Nitrogen Oxides	140-154	tudor domain containing 7	Rattus norvegicus	18-22
9578472-0	1998	Chemical modifications of the vasoconstrictor peptide angiotensin II by nitrogen oxides (NO, HNO2, HOONO)--evaluation by mass spectrometry.	Nitrogen Oxides	72-87	angiotensinogen	Homo sapiens	54-68
10684491-10	1998	In the presence of bradykinin and 27% cyclic strain, production of nitrogen oxides and endothelial NO synthase activity were increased by 110 +/- 37% and 135 +/- 7%, respectively (P <.05 compared with control); however, we observed no significant increase in cell number (5 +/- 5%), despite an 86 +/- 7% increase in [(3)H]thymidine incorporation (P <.05).	Nitrogen Oxides	67-82	kininogen 1	Homo sapiens	19-29
9530221-4	1998	The production of nitrogen oxides by human umbilical vein endothelial cells (HUVECs) was measured after 1, 12, 24, and 48 h of incubation with VEGF.	Nitrogen Oxides	18-33	vascular endothelial growth factor A	Homo sapiens	143-147
9398256-3	1997	Numerous studies have established that peroxynitrite-derived nitrogen oxides are present following nNOS turnover.	Nitrogen Oxides	61-76	nitric oxide synthase 1	Homo sapiens	99-103
10493821-2	1999	We set out to determine the mechanisms by which different nitrogen oxide derivatives modulate PGHS-1 activity.	Nitrogen Oxides	58-72	prostaglandin-endoperoxide synthase 1	Homo sapiens	94-100
9368361-5	1997	In this strain the nitrite reductase production was primarily regulated by an anr gene when grown under anaerobic conditions, but when grown under aerobic conditions it was regulated by both an anr gene and nitrogen oxide.	Nitrogen Oxides	207-221	nitrite reductase	Pseudomonas aeruginosa PAO1	19-36
9601833-9	1997	Relations between the altered insulin sensitivity and arginine, the precursor of nitrogen oxide, apparent only in PHT could be a stimulus for seeking associations with endothelial damage described in insulin resistant conditions.	Nitrogen Oxides	81-95	insulin	Homo sapiens	30-37
9601833-9	1997	Relations between the altered insulin sensitivity and arginine, the precursor of nitrogen oxide, apparent only in PHT could be a stimulus for seeking associations with endothelial damage described in insulin resistant conditions.	Nitrogen Oxides	81-95	insulin	Homo sapiens	200-207
7543000-6	1995	The production of nitrogen oxides (NOx), assessed by chemiluminescence, and nitric oxide synthase activity, assessed by arginine/citrulline conversion were increased in TGF beta 1-treated cells.	Nitrogen Oxides	18-33	transforming growth factor beta 1	Bos taurus	169-179
10756724-2	1997	A special attention is given to the myorelaxing effects of EDRF, identified as nitrogen oxide (NO) and its production mechanism, at the vascular level, with the participation of cGMP as intracellular second messenger.	Nitrogen Oxides	79-93	alpha hemoglobin stabilizing protein	Homo sapiens	59-63
7543000-6	1995	The production of nitrogen oxides (NOx), assessed by chemiluminescence, and nitric oxide synthase activity, assessed by arginine/citrulline conversion were increased in TGF beta 1-treated cells.	Nitrogen Oxides	35-38	transforming growth factor beta 1	Bos taurus	169-179
7861129-5	1995	These results suggest that astrocytes, via release of an iron-nitrogen oxide complex, may be involved in a regulatory loop of ET-1 production at the level of the blood-brain barrier.	Nitrogen Oxides	62-76	endothelin 1	Rattus norvegicus	126-130
7538104-10	1995	The inhibition was abolished by the addition of NG-monomethyl-L-arginine, an inhibitor of NO2- synthesis, suggesting that the reactive nitrogen oxide intermediate is involved in hM-CSF-induced inhibition of L1210 growth.	Nitrogen Oxides	135-149	colony stimulating factor 1	Homo sapiens	178-184
8423095-0	1993	Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice.	Nitrogen Oxides	95-110	tumor necrosis factor	Mus musculus	39-66
8088863-2	1994	Macrophage-like cells (Mm1) pretreated with IL-6 served as the source of the nitrogen oxides.	Nitrogen Oxides	77-92	prefoldin 5	Mus musculus	23-26
8088863-2	1994	Macrophage-like cells (Mm1) pretreated with IL-6 served as the source of the nitrogen oxides.	Nitrogen Oxides	77-92	interleukin 6	Mus musculus	44-48
8213997-2	1993	Rickettsia conorii infection of a mouse fibroblast cell line was inhibited in a dose-dependent manner by nitrogen oxide synthesized by eukaryotic host cells stimulated by interferon-gamma or tumor necrosis factor-alpha.	Nitrogen Oxides	105-119	interferon gamma	Mus musculus	171-218
7682068-3	1993	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-).	Nitrogen Oxides	87-101	nitric oxide synthase 2	Rattus norvegicus	0-31
7682068-3	1993	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-).	Nitrogen Oxides	87-101	nitric oxide synthase 2	Rattus norvegicus	33-37
1502182-2	1992	The single free cysteine of serum albumin, Cys-34, is particularly reactive toward nitrogen oxides (most likely nitrosonium ion) under physiologic conditions, primarily because of its anomalously low pK; given its abundance in plasma, where it accounts for approximately 0.5 mM thiol, we hypothesized that this plasma protein serves as a reservoir for nitric oxide produced by the endothelial cell.	Nitrogen Oxides	83-98	albumin	Homo sapiens	28-41
1381395-0	1992	Cytotoxic activity and production of toxic nitrogen oxides by macrophages treated with IFN-gamma and monoclonal antibodies against the 73-kDa lipopolysaccharide receptor.	Nitrogen Oxides	43-58	interferon gamma	Mus musculus	87-96
1528300-5	1992	The results showed that the major cytolytic mechanism against BP6-Tu2 and U 937 tumor cell lines is L-arginine-dependent nitrogen oxide synthesis of activated rat peritoneal macrophages.	Nitrogen Oxides	121-135	BP6	Homo sapiens	62-65
1354651-11	1992	In the case of IL-10, this suppression of nitrogen oxide production appears to result from an inhibition of TNF-alpha synthesis leading to defective macrophage stimulation.	Nitrogen Oxides	42-56	interleukin 10	Mus musculus	15-20
1354651-11	1992	In the case of IL-10, this suppression of nitrogen oxide production appears to result from an inhibition of TNF-alpha synthesis leading to defective macrophage stimulation.	Nitrogen Oxides	42-56	tumor necrosis factor	Mus musculus	108-117
1371193-0	1992	Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides.	Nitrogen Oxides	71-86	insulin	Homo sapiens	0-7
1371193-2	1992	Data from three model systems support the hypothesis that L-arginine-derived nitrogen oxides (NOs) mediate insulin release stimulated by L-arginine in the presence of D-glucose and by the hypoglycemic drug tolbutamide.	Nitrogen Oxides	77-92	insulin	Homo sapiens	107-114
1910638-6	1991	Under basal conditions, the release of nitrogen oxides was 0.2 nmol/100 mg protein and was increased approximately two-fold by 0.1 micrograms, bradykinin.	Nitrogen Oxides	39-54	kininogen 1	Bos taurus	143-153
2121110-7	1990	We found that no single cytokine, but rather a specific combination of tumor necrosis factor, interleukin-1, interferon-gamma, and endotoxin, were required for maximal induction of HC nitrogen oxide production.	Nitrogen Oxides	184-198	interleukin 1 alpha	Homo sapiens	94-107
1902865-10	1991	We conclude that induction of inorganic nitrogen oxide synthesis from L-arginine by the synergistic combination of IFN gamma, TNF alpha, and LPS accounts for most of the biologic activity of CM, and that IFN gamma is the major priming factor.	Nitrogen Oxides	40-54	tumor necrosis factor	Mus musculus	126-135
1707354-8	1991	Removal of extracellular calcium abolished basal and bradykinin-stimulated release of nitrogen oxides.	Nitrogen Oxides	86-101	kininogen 1	Bos taurus	53-63
1868189-2	1991	Structurally, EDRF is likely to be NO or a related nitrogen oxide-containing compound.	Nitrogen Oxides	51-65	alpha hemoglobin stabilizing protein	Homo sapiens	14-18
1902865-10	1991	We conclude that induction of inorganic nitrogen oxide synthesis from L-arginine by the synergistic combination of IFN gamma, TNF alpha, and LPS accounts for most of the biologic activity of CM, and that IFN gamma is the major priming factor.	Nitrogen Oxides	40-54	interferon gamma	Mus musculus	115-124
1905984-4	1991	Addition of arginase before infection inhibited the bacteriostatic ability of IFN-gamma-pulsed macrophages as did addition of NG-monomethyl L-arginine, an inhibitor of the synthesis of inorganic nitrogen oxide.	Nitrogen Oxides	195-209	interferon gamma	Mus musculus	78-87
1905984-7	1991	These results imply that nitric oxide or another inorganic nitrogen oxide is an important effector molecule in restricting growth of M. tuberculosis in IFN-gamma-pulsed murine macrophages.	Nitrogen Oxides	59-73	interferon gamma	Mus musculus	152-161
2121110-7	1990	We found that no single cytokine, but rather a specific combination of tumor necrosis factor, interleukin-1, interferon-gamma, and endotoxin, were required for maximal induction of HC nitrogen oxide production.	Nitrogen Oxides	184-198	interferon gamma	Homo sapiens	109-125
2154196-1	1990	Interferon-gamma induces the L-Arginine-dependent pathway that leads to the formation of nitrogen oxides in murine macrophages with subsequent inhibition of mitochondrial non-heme iron-dependent enzymes.	Nitrogen Oxides	89-104	interferon gamma	Mus musculus	0-16
2115549-0	1990	Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.	Nitrogen Oxides	122-136	interferon gamma	Mus musculus	150-159
2109093-0	1990	Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin.	Nitrogen Oxides	31-46	interferon gamma	Homo sapiens	62-78
2109093-0	1990	Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin.	Nitrogen Oxides	31-46	tumor necrosis factor	Homo sapiens	99-120
2109093-0	1990	Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin.	Nitrogen Oxides	31-46	interleukin 1 alpha	Homo sapiens	122-135
2109093-4	1990	In this study, we tested interferon gamma, tumor necrosis factor, interleukin-1, interleukin-2, muramyl dipeptide, and endotoxin for their effects on production of nitrogen oxides by endothelial cells.	Nitrogen Oxides	164-179	interferon gamma	Homo sapiens	25-64
2109093-4	1990	In this study, we tested interferon gamma, tumor necrosis factor, interleukin-1, interleukin-2, muramyl dipeptide, and endotoxin for their effects on production of nitrogen oxides by endothelial cells.	Nitrogen Oxides	164-179	interleukin 1 alpha	Homo sapiens	66-79
2109093-4	1990	In this study, we tested interferon gamma, tumor necrosis factor, interleukin-1, interleukin-2, muramyl dipeptide, and endotoxin for their effects on production of nitrogen oxides by endothelial cells.	Nitrogen Oxides	164-179	interleukin 2	Homo sapiens	81-94
2784476-15	1989	and/or a closely related, highly reactive nitrogen oxide such as NO2, during their conversion of L-arginine to NO2-/NO3-.	Nitrogen Oxides	42-56	NBL1, DAN family BMP antagonist	Mus musculus	116-119
16666314-0	1988	The Conversion of Nitrite to Nitrogen Oxide(s) by the Constitutive NAD(P)H-Nitrate Reductase Enzyme from Soybean.	Nitrogen Oxides	29-43	chalcone reductase CHR1	Glycine max	83-92
6973753-0	1981	[Serum alpha 1-antitrypsin level in persons with long-term exposure to nitrogen oxides].	Nitrogen Oxides	71-86	serpin family A member 1	Homo sapiens	7-26
2829982-1	1987	In vivo formation of nitrogen oxide in the mouse liver kept on purely protein diet (casein) was shown by ESR method.	Nitrogen Oxides	21-35	esterase 5 regulator	Mus musculus	105-108
6135148-2	1983	Recent studies have suggested that cyclic GMP accumulation in platelets mediates the antiaggregatory effects of certain nitrogen oxide-containing agents such as sodium nitroprusside, nitric oxide, nitrosoguanidines, and related agents.	Nitrogen Oxides	120-134	5'-nucleotidase, cytosolic II	Homo sapiens	42-45
2441158-1	1987	The effects of glyceryl trinitrate-induced desensitization on relaxations and/or elevated cyclic GMP levels due to the nitrogen oxide-containing vasodilators (glyceryl trinitrate and sodium nitroprusside), the endothelium-dependent vasodilators (acetylcholine and the Ca2+ ionophore A23187), and the atrial peptides (atriopeptin II) were investigated in the rat thoracic aorta and human coronary artery.	Nitrogen Oxides	119-133	5'-nucleotidase, cytosolic II	Homo sapiens	97-100
16662132-0	1981	Evolution of Nitrogen Oxide(s) during In Vivo Nitrate Reductase Assay of Soybean Leaves.	Nitrogen Oxides	13-27	chalcone reductase CHR1	Glycine max	54-63
533371-0	1979	Activity of N-acetyl-beta-glucosaminidase in lymphocytes of rats exposed to mixture of nitrogen oxides and chlorine.	Nitrogen Oxides	87-102	O-GlcNAcase	Rattus norvegicus	12-41
533371-1	1979	Activity of N-acetyl-beta-glucosaminidase (GS) has been cytochemically studied in peripheral blood lymphocytes of rats exposed to the mixture of nitrogen oxides (1.22 mg/m3) and chlorine (1.02 mg/m3) during a period of 12 weeks.	Nitrogen Oxides	145-160	O-GlcNAcase	Rattus norvegicus	12-41
533371-1	1979	Activity of N-acetyl-beta-glucosaminidase (GS) has been cytochemically studied in peripheral blood lymphocytes of rats exposed to the mixture of nitrogen oxides (1.22 mg/m3) and chlorine (1.02 mg/m3) during a period of 12 weeks.	Nitrogen Oxides	145-160	O-GlcNAcase	Rattus norvegicus	43-45
755246-0	1978	Changes of beta-glucuronidase activity in peripheral blood lymphocytes in rats exposed to a mixture of nitrogen oxides and chlorine.	Nitrogen Oxides	103-118	glucuronidase, beta	Rattus norvegicus	11-29
7258904-2	1980	Nitrogen oxide leads to the formation of compounds of the N O X type, characterised by the following equilibrium constants: 1.93 X 10(-2) for sodium ascorbate, 1.96 X 10(-2) for cysteine, 2.79 X 10(-2) for guanidine, 1.43 X 10(-3) for glutathion, 0.384 for sarcosin, 4.6 X 10(-2) for galacturonic acid, and 1.8 X 10(-3) for neuraminic acid.	Nitrogen Oxides	0-14	kelch like family member 41	Homo sapiens	257-265
755246-1	1978	The activity of beta-glucuronidase (BG) was tested cytochemically in the lymphocytes of peripheral blood of rats exposed to a mixture of nitrogen oxides (1.22 mg/m3) and chlorine (1.02 mg/m3) for 12 weeks.	Nitrogen Oxides	137-152	glucuronidase, beta	Rattus norvegicus	16-34
755246-1	1978	The activity of beta-glucuronidase (BG) was tested cytochemically in the lymphocytes of peripheral blood of rats exposed to a mixture of nitrogen oxides (1.22 mg/m3) and chlorine (1.02 mg/m3) for 12 weeks.	Nitrogen Oxides	137-152	glucuronidase, beta	Rattus norvegicus	36-38
605756-6	1977	However, increased ALA-D activity in erythrocytes found in these cases may be of some importance in evaluation of exposure to nitrogen oxides.	Nitrogen Oxides	126-141	aminolevulinate dehydratase	Homo sapiens	19-24
5218627-0	1966	[Changes in the cholinesterase activity of rats following prolonged inhalation of nitrogen oxides].	Nitrogen Oxides	82-97	butyrylcholinesterase	Rattus norvegicus	16-30
4121280-0	1973	Lifelong exposure of SPF rats to automotive exhaust gas: dilution containing 20 ppm of nitrogen oxides.	Nitrogen Oxides	87-102	SEC14-like lipid binding 2	Rattus norvegicus	21-24
31188127-1	2019	Beewolf wasp eggs release nitrogen oxides to provide protection against fungi and other microbes.	Nitrogen Oxides	26-41	WASP actin nucleation promoting factor	Homo sapiens	8-12
31559421-5	2020	Here we discuss the importance of the AOX pathway in dealing with elevated carbon dioxide (CO2), nitrogen oxides (NOx), ozone (O3) and the main abiotic stresses induced by climate change.	Nitrogen Oxides	97-112	acyl-CoA oxidase 1	Homo sapiens	38-41
31559421-5	2020	Here we discuss the importance of the AOX pathway in dealing with elevated carbon dioxide (CO2), nitrogen oxides (NOx), ozone (O3) and the main abiotic stresses induced by climate change.	Nitrogen Oxides	114-117	acyl-CoA oxidase 1	Homo sapiens	38-41
29679365-9	2018	In contrast, risk of COPD exacerbation rose when a shortening of the time lag between exposure to NOx and hospital admission was considered (RR 1.02-1.04; p < 0.05).	Nitrogen Oxides	98-101	COPD	Homo sapiens	21-25
30784837-9	2019	These results are useful for planning the reduction of NOx emissions in city environments and for elucidating relationships between regional NOx emissions and atmospheric NO3- pollution or deposition.	Nitrogen Oxides	141-144	NBL1, DAN family BMP antagonist	Homo sapiens	171-174
30478764-8	2019	When considering univariate associations between pollution and health outcomes, the only significant association existed between nitrogen oxides and COPD being negatively correlated.	Nitrogen Oxides	129-144	COPD	Homo sapiens	149-153
29298528-1	2018	CONTEXT: Exogenous nitrogen oxides must be made bioavailable to sustain normal physiology because nitric oxide synthase (NOS) deficient mice are viable.	Nitrogen Oxides	19-34	nitric oxide synthase 1, neuronal	Mus musculus	98-119
30582863-1	2018	OBJECTIVE: To determine the features of the nitrogen oxide metabolism and risk of developing endothelial dysfunc-tion in children with e-NOS 4a/4b gene polymorphism, who live under prolonged enter 137Cs to the body.	Nitrogen Oxides	44-58	nitric oxide synthase 3	Homo sapiens	135-140
29948709-6	2018	The result shows that NWD made from tap water helps the engine to reduce nitrogen oxide (NOx) by 32%.	Nitrogen Oxides	73-87	nuclear RNA export factor 1	Homo sapiens	36-39
29948709-6	2018	The result shows that NWD made from tap water helps the engine to reduce nitrogen oxide (NOx) by 32%.	Nitrogen Oxides	89-92	nuclear RNA export factor 1	Homo sapiens	36-39
29098799-5	2018	RESULTS: A one standard deviation (1-SD: 2 ppb) increase in prenatal non-freeway nitrogen oxides was associated with 33% (P = 0.01) higher leptin and 9% higher high molecular weight adiponectin levels (P = 0.07) in cord blood.	Nitrogen Oxides	81-96	adiponectin, C1Q and collagen domain containing	Homo sapiens	182-193
29561787-3	2018	NH3 and HCN are common precursors of NOx from the decomposition of N-containing compounds.	Nitrogen Oxides	37-40	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	8-11
30784837-8	2019	Annually, NOx from coal combustion, vehicle exhausts, biomass burning, and microbial N cycle contributed 28 +- 12%, 29 +- 17%, 27 +- 15%, and 16 +- 7% to NO3- in PM2.5, respectively, showing actually comparable contributions between non-fossil NOx (43 +- 16%) and fossil NOx (57 +- 21%).	Nitrogen Oxides	10-13	NBL1, DAN family BMP antagonist	Homo sapiens	154-157
29762035-4	2018	Diffuse reflectance infrared Fourier transform spectroscopy studies showed NO3- as the main adsorbed nitrogen oxide specimen on the surface.	Nitrogen Oxides	101-115	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
29679365-12	2018	In conclusion, the study demonstrates a salient influence of a co-existing cardiovascular malady on the appearance of COPD-related respiratory exacerbations when the pollutant SO2 and NOx contents rose.	Nitrogen Oxides	184-187	COPD	Homo sapiens	118-122
28751572-7	2017	Positive associations were also observed for nitrogen oxides with interleukin-6 and for black carbon, sulfate, and ozone with tumor necrosis factor receptor 2.	Nitrogen Oxides	45-60	interleukin 6	Homo sapiens	66-79
28390289-3	2017	Although the pathogenesis of hypertension is generally assumed to involve microvascular bed reduction and an increase in peripheral vascular resistance due to a decrease in nitrogen oxide (NOx) production after vascular endothelial growth factor (VEGF) inhibition, the effects of hypertension on vascular endothelial function in actual patients remain unclear.	Nitrogen Oxides	173-187	vascular endothelial growth factor A	Homo sapiens	247-251
28739973-9	2017	This can explain the variable responses to NO3-and NO2-supplementation in clinical trials and reveals dietary strategies for promoting the generation of pleiotropic nitrogen oxide-derived lipid signaling mediators.	Nitrogen Oxides	165-179	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
28516763-3	2017	In this study, the source of NOx was investigated by the isotopic composition (delta15N) of particulate nitrate (p-NO3-) at Beihuangcheng Island (BH), a regional background site in North China.	Nitrogen Oxides	29-32	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
28516763-9	2017	This study confirmed that isotope-modeling by delta15N-NO3- is a promising tool for partitioning NOx sources and provides guidance to policymakers with regard to options for NOx reduction in North China.	Nitrogen Oxides	97-100	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
28390289-3	2017	Although the pathogenesis of hypertension is generally assumed to involve microvascular bed reduction and an increase in peripheral vascular resistance due to a decrease in nitrogen oxide (NOx) production after vascular endothelial growth factor (VEGF) inhibition, the effects of hypertension on vascular endothelial function in actual patients remain unclear.	Nitrogen Oxides	189-192	vascular endothelial growth factor A	Homo sapiens	247-251
28707660-2	2017	The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators.	Nitrogen Oxides	117-131	epoxide hydrolase 2	Rattus norvegicus	4-7
28355418-12	2017	Nitrogen oxides level can be an indicator of oxidation level and Cr6+ formation (R = 0.93).	Nitrogen Oxides	0-15	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	65-68
25816055-9	2015	Annual NOx concentration was also positively associated with levels of CRP (3.2%; 95% CI: 0.3, 6.1 per 20 mug/m3), but the effect estimate was more sensitive to model adjustments.	Nitrogen Oxides	7-10	C-reactive protein	Homo sapiens	71-74
25898227-8	2015	Long-term exposure to NOx was associated with decreased levels of interleukin (IL)-2, IL-8, IL-10 and tumor necrosis factor-alpha in Italy, but not in Sweden.	Nitrogen Oxides	22-25	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
25564368-9	2016	We found positive associations of traffic-related pollutants (EC, BC, primary organic carbon, PM 0.25-2.5 PAH and/or PM 0.25 PAH, and NOx) with NFE2L2, Nrf2-mediated genes (HMOX1, NQO1, and SOD2), CYP1B1, IL1B, and SELP.	Nitrogen Oxides	134-137	NFE2 like bZIP transcription factor 2	Homo sapiens	144-150
26421866-8	2015	Exposure to NOx was significantly associated with mortality owing to respiratory diseases: relative risk (RR)=1.035 (95% confidence interval [CI]: 1.008-1.063) for lag 2, RR=1.064 (95%CI: 1.017-1.112) lag 3, RR=1.055 (95%CI: 1.025-1.085) lag 4, and RR=1.042 (95%CI: 1.010-1.076) lag 5.	Nitrogen Oxides	12-15	granulysin	Homo sapiens	164-169
26421866-8	2015	Exposure to NOx was significantly associated with mortality owing to respiratory diseases: relative risk (RR)=1.035 (95% confidence interval [CI]: 1.008-1.063) for lag 2, RR=1.064 (95%CI: 1.017-1.112) lag 3, RR=1.055 (95%CI: 1.025-1.085) lag 4, and RR=1.042 (95%CI: 1.010-1.076) lag 5.	Nitrogen Oxides	12-15	lymphocyte activating 3	Homo sapiens	201-206
26421866-8	2015	Exposure to NOx was significantly associated with mortality owing to respiratory diseases: relative risk (RR)=1.035 (95% confidence interval [CI]: 1.008-1.063) for lag 2, RR=1.064 (95%CI: 1.017-1.112) lag 3, RR=1.055 (95%CI: 1.025-1.085) lag 4, and RR=1.042 (95%CI: 1.010-1.076) lag 5.	Nitrogen Oxides	12-15	LAG5	Homo sapiens	279-284
25898227-8	2015	Long-term exposure to NOx was associated with decreased levels of interleukin (IL)-2, IL-8, IL-10 and tumor necrosis factor-alpha in Italy, but not in Sweden.	Nitrogen Oxides	22-25	interleukin 10	Homo sapiens	92-97
25898227-8	2015	Long-term exposure to NOx was associated with decreased levels of interleukin (IL)-2, IL-8, IL-10 and tumor necrosis factor-alpha in Italy, but not in Sweden.	Nitrogen Oxides	22-25	tumor necrosis factor	Homo sapiens	102-129
25898227-10	2015	Combining data from Italy and Sweden we only observed a significant association between long-term exposure to NOx and decreased levels of circulating IL-8.	Nitrogen Oxides	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	150-154