PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7649284-4	1995	We find the most probable binding modes for the two inhibitors to be a folded conformation, with one distal amidino group extending into the S1 pocket, forming a salt-bridge with FXa Asp-189, and the other positively charged group fitting into the S4 subsite, and stabilized by a cation-pi interaction.	amidino	108-115	coagulation factor X	Homo sapiens	179-182
161807-2	1979	The antitrypsin, antiplasmin and antithrombin activities of bis(amidinobenzylidene)- and bis(amidinobenzyl)cycloalkanones are not markedly affected if the amidino group is substituted by an uncharged residue (H, OCH3, Cl, Br, NO2).	amidino	64-71	serpin family C member 1	Homo sapiens	33-45
19999737-1	1973	A series of amidino compounds has been investigated for their inhibitory effects on C1s, C1r, and generation of C1s.	amidino	12-19	complement C1s	Homo sapiens	84-87
19999737-1	1973	A series of amidino compounds has been investigated for their inhibitory effects on C1s, C1r, and generation of C1s.	amidino	12-19	complement C1s	Homo sapiens	112-115
29133046-3	2018	Additional Western blot analyses showed different mechanisms of cytostatic activity between compounds 10c and 11f that could be associated with the nature of aromatic substituent at 1-(1,2,3-triazolyl) and amidino moiety at C-5 position of benzimidazole ring.	amidino	206-213	Rho GTPase activating protein 9	Homo sapiens	102-105
28137860-3	2017	Glycine amidinotransferase (GATM) catalyzes the rate-limiting step of creatine biosynthesis: the transfer of an amidino group from arginine to glycine to form ornithine and guanidinoacetate.	amidino	8-15	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	Mus musculus	28-32
23623932-6	2013	In contrast, the inhibiting effect of antisera against dynorphin B or alpha-neo-endorphin on amidino-TAPA-induced antinociception was eliminated in mice whose spinal mMOR-1K had been knocked-down using the antisense ODN for exon-13 of mMOR-1 gene.	amidino	93-100	opioid receptor, mu 1	Mus musculus	166-172
23623932-7	2013	Moreover, the inhibiting effect of antisera against dynorphin A or [Leu(5)]enkephalin on amidino-TAPA-induced antinociception was eliminated in mice whose spinal mMOR-1L had been knocked-down using the antisense ODN for exon-14 of mMOR-1 gene.	amidino	89-96	opioid receptor, mu 1	Mus musculus	162-168
15635223-0	2005	Amidino-containing Schiff base copper(II) and iron(III) chelates as a thrombin inhibitor.	amidino	0-7	coagulation factor II, thrombin	Bos taurus	70-78
11087565-3	2000	A novel series of fXa inhibitors incorporating an amidino 6,5-fused bicyclic moiety at the P1 position has been designed and synthesized based on molecular modeling studies.	amidino	50-57	coagulation factor X	Homo sapiens	18-21
6460342-0	1981	Inhibitory effect of amidino-substituted heterocyclic compounds on the amidase activity of plasmin and of high and low molecular weight urokinase and on urokinase-induced plasminogen activation.	amidino	21-28	plasminogen	Homo sapiens	91-98
19128974-1	2009	In the early 1990"s, we reported on the low-molecular selective fXa inhibitor DX-9065a having two amidino groups.	amidino	98-105	coagulation factor X	Homo sapiens	64-67
17482821-1	2007	We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities.	amidino	73-80	complement C5	Homo sapiens	97-100
17482821-1	2007	We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities.	amidino	73-80	complement C2	Homo sapiens	212-215
15186830-4	2004	Introduction of a guanidino or an amidino group enhanced the in vitro inhibitory activity of TP comparing with formerly reported inhibitor 1.	amidino	34-41	thymidine phosphorylase	Homo sapiens	93-95
9268299-5	1997	The 2.9 A structure determination of the catalytic domain of human tPA in complex with the bis-benzamidine inhibitor 2, 7-bis-(4-amidinobenzylidene)-cycloheptan-1-one reveals a three-site interaction, salt bridge formation of the proximal amidino group of the inhibitor with Asp189 in the primary specificity pocket, extensive hydrophobic surface burial, and a weak electrostatic interaction between the distal amidino group of the inhibitor and two carbonyl oxygens of the protein.	amidino	129-136	plasminogen activator, tissue type	Homo sapiens	67-70
9268299-5	1997	The 2.9 A structure determination of the catalytic domain of human tPA in complex with the bis-benzamidine inhibitor 2, 7-bis-(4-amidinobenzylidene)-cycloheptan-1-one reveals a three-site interaction, salt bridge formation of the proximal amidino group of the inhibitor with Asp189 in the primary specificity pocket, extensive hydrophobic surface burial, and a weak electrostatic interaction between the distal amidino group of the inhibitor and two carbonyl oxygens of the protein.	amidino	239-246	plasminogen activator, tissue type	Homo sapiens	67-70
9033393-7	1997	This represents the first reported three-dimensional structure of a thrombin/ inhibitor complex where the specificity pocket of the enzyme is occupied by a chemical moiety other than a guanidino or an amidino group.	amidino	201-208	coagulation factor II	Rattus norvegicus	68-76
9033393-11	1997	The neutral indole group may be of pharmacological significance because the severe hypotension and respiratory distress observed following the administration of some thrombin inhibitors have been linked to the positively charged guanidino or amidino functionalities.	amidino	242-249	coagulation factor II	Rattus norvegicus	166-174
8759635-8	1996	Due to the modification of the amidino group as well as of the carboxylate group, 18 completely lost its ability to interact with purified platelet GP IIb-IIIa.	amidino	31-38	integrin alpha 2b	Mus musculus	148-154
3602050-3	1987	In contrast to the antithrombin activity, toxicity and side effects of the amidino compounds are not dependent on the position of the amidino group within the molecule.	amidino	75-82	serpin family C member 1	Homo sapiens	19-31
3602050-5	1987	The nonspecific pharmacodynamic effects of synthetic thrombin inhibitors of the benzamidine type must be caused by the highly basic amidino group (the benzamidine moiety) of the compounds.	amidino	132-139	coagulation factor II, thrombin	Homo sapiens	53-61