PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16111802-0	2006	Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity.	brostallicin	48-60	BCL2 apoptosis regulator	Homo sapiens	119-124
16111802-0	2006	Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity.	brostallicin	48-60	caspase 3	Homo sapiens	141-150
16111802-5	2006	The mechanism underlying the interaction involved the apoptotic pathway as we demonstrated an increase in Bcl-2 protein levels and decrease in caspase 3 activity with the Silibinin-Brostallicin combination.	brostallicin	181-193	BCL2 apoptosis regulator	Homo sapiens	106-111
16111802-5	2006	The mechanism underlying the interaction involved the apoptotic pathway as we demonstrated an increase in Bcl-2 protein levels and decrease in caspase 3 activity with the Silibinin-Brostallicin combination.	brostallicin	181-193	caspase 3	Homo sapiens	143-152
23771052-4	2013	We tested whether pretreatment of heavily GST-methylated prostate cancer cells with demethylating agents could enhance the activity of brostallicin.	brostallicin	135-147	glutathione S-transferase kappa 1	Homo sapiens	42-45
15090736-5	2004	As a consequence, cells expressing relatively high GST/GSH levels are more susceptible to treatment with brostallicin.	brostallicin	105-117	glutathione S-transferase kappa 1	Homo sapiens	51-54
23771052-13	2013	These findings highlight the potential therapeutic value of combining demethylating agents and brostallicin in tumors with GST methylation that poorly respond to brostallicin.	brostallicin	95-107	glutathione S-transferase kappa 1	Homo sapiens	123-126
19950984-5	2010	Direct evidence that both GSTP1-1 and GSTM2-2 isoenzymes catalyze the Michael addition reaction of GSH to brostallicin has been obtained both by an HPLC-MS technique and by a new fluorometric assay.	brostallicin	106-118	glutathione S-transferase pi 1	Homo sapiens	26-33
19950984-5	2010	Direct evidence that both GSTP1-1 and GSTM2-2 isoenzymes catalyze the Michael addition reaction of GSH to brostallicin has been obtained both by an HPLC-MS technique and by a new fluorometric assay.	brostallicin	106-118	glutathione S-transferase mu 2	Homo sapiens	38-45