PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30140092-0	2018	Study Design of a Phase II Clinical Trial to Assess the Efficacy and Safety of Eperisone in Japanese Type 2 Diabetes Patients with Risk and Non-risk Alleles of CDKAL1.	eperisone	79-88	CDK5 regulatory subunit associated protein 1 like 1	Homo sapiens	160-166
3570107-10	1987	Although HSR-770 acts on the spinal cord and supraspinal level on which eperisone has been reported to act, HSR-733 may mainly act on the spinal cord.	eperisone	72-81	component of Sp100-rs	Mus musculus	9-12
3570107-12	1987	HSR-770, which has equipotent muscle relaxant activity to eperisone, exerted strong inhibitory effects on oxotremorine-induced tremor and weak inhibitory effects on spontaneous motor activity in the Animex method using mice, as compared with eperisone.	eperisone	58-67	component of Sp100-rs	Mus musculus	0-3
3570107-12	1987	HSR-770, which has equipotent muscle relaxant activity to eperisone, exerted strong inhibitory effects on oxotremorine-induced tremor and weak inhibitory effects on spontaneous motor activity in the Animex method using mice, as compared with eperisone.	eperisone	242-251	component of Sp100-rs	Mus musculus	0-3
30140092-3	2018	Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1-deficient mice.	eperisone	0-9	CDK5 regulatory subunit associated protein 1-like 1	Mus musculus	87-93
30140092-4	2018	We have launched a phase II clinical study to investigate the potential anti-diabetic effect of eperisone in T2D patients carrying risk or non-risk alleles of CDKAL1.	eperisone	96-105	CDK5 regulatory subunit associated protein 1 like 1	Homo sapiens	159-165
30140092-6	2018	We also examined whether the efficacy of eperisone in T2D patients is associated with CDKAL1 activity.	eperisone	41-50	CDK5 regulatory subunit associated protein 1 like 1	Homo sapiens	86-92
19219743-0	2009	Characterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone.	eperisone	87-96	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-41
21623702-8	2011	Carbonyl reduction of eperisone by microsomal 11beta-HSD 1 may significantly contribute to the metabolic disposition of eperisone in human and (-)-R-isomer is preferentially reduced by this enzyme.	eperisone	22-31	RNA, U1 small nuclear 1	Homo sapiens	35-58
21623702-8	2011	Carbonyl reduction of eperisone by microsomal 11beta-HSD 1 may significantly contribute to the metabolic disposition of eperisone in human and (-)-R-isomer is preferentially reduced by this enzyme.	eperisone	120-129	RNA, U1 small nuclear 1	Homo sapiens	35-58
19219743-2	2009	The objective of this study was to characterize the metabolic pathway involved in the biotransformation of eperisone mediated by human cytochrome P450 (CYP) enzymes.	eperisone	107-116	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	135-150
19219743-2	2009	The objective of this study was to characterize the metabolic pathway involved in the biotransformation of eperisone mediated by human cytochrome P450 (CYP) enzymes.	eperisone	107-116	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	152-155
19219743-7	2009	In addition, intestinal microsomes metabolized eperisone to M3 and M4 via CYP2J2- and CYP3A4-mediated reactions, which are supposed to contribute to presystemic metabolism of eperisone.	eperisone	47-56	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	74-80
19219743-7	2009	In addition, intestinal microsomes metabolized eperisone to M3 and M4 via CYP2J2- and CYP3A4-mediated reactions, which are supposed to contribute to presystemic metabolism of eperisone.	eperisone	47-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
19219743-7	2009	In addition, intestinal microsomes metabolized eperisone to M3 and M4 via CYP2J2- and CYP3A4-mediated reactions, which are supposed to contribute to presystemic metabolism of eperisone.	eperisone	175-184	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	74-80
19219743-7	2009	In addition, intestinal microsomes metabolized eperisone to M3 and M4 via CYP2J2- and CYP3A4-mediated reactions, which are supposed to contribute to presystemic metabolism of eperisone.	eperisone	175-184	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
12900854-4	2003	The chicken alpha(1)-AGP showed higher resolution for eperisone, pindolol and tolperisone than cd-alpha(1)-AGP or recombinant alpha(1)-AGP.	eperisone	54-63	orosomucoid 1 (ovoglycoprotein)	Gallus gallus	12-24
35136056-6	2022	Eperisone also significantly inhibited transforming growth factor-beta1-dependent transdifferentiation of LL29 cells into myofibroblasts.	eperisone	0-9	transforming growth factor beta 1	Homo sapiens	39-71