PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16201750-4	2005	(i) Yeast one-hybrid-based random mutagenesis was first used to identify a number of SEI-1 residues important for LexA-mediated transactivation, including residues L51, K52, L53, H54, L57, and L69 located within the heptad repeat (residues 30-88), a domain required for LexA-mediated transactivation, and two residues M219 and L228 at the C-terminal segment that contributes to transactivation through modulating the heptad repeat.	lexa	114-118	seipin	Saccharomyces cerevisiae S288C	85-90
16201750-4	2005	(i) Yeast one-hybrid-based random mutagenesis was first used to identify a number of SEI-1 residues important for LexA-mediated transactivation, including residues L51, K52, L53, H54, L57, and L69 located within the heptad repeat (residues 30-88), a domain required for LexA-mediated transactivation, and two residues M219 and L228 at the C-terminal segment that contributes to transactivation through modulating the heptad repeat.	lexa	270-274	seipin	Saccharomyces cerevisiae S288C	85-90
10655212-2	2000	A LexA-Sin3 fusion protein represses transcription of promoters with LexA binding sites.	lexa	2-6	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	7-11
16024791-3	2005	Rpm2p expressed as a fusion protein with green fluorescent protein localizes to the nucleus and activates transcription from promoters containing lexA-binding sites when fused to a heterologous DNA binding domain, lexA.	lexa	146-150	ribonuclease P	Saccharomyces cerevisiae S288C	0-5
14769061-3	2004	It is examined in this paper to what extent our previous model was correct and how, using the crystal structure of the operator-free LexA dimer we can predict an improved model of LexA dimer bound to recA operator.	lexa	133-137	RAD51 recombinase	Homo sapiens	200-204
12468546-5	2003	lexA-Med1 and lexA-Srb7 are both cryptic activators that become active in the absence of Srb8, Srb10, Srb11, or Sin4.	lexa	0-4	Med1p	Saccharomyces cerevisiae S288C	5-9
12468546-5	2003	lexA-Med1 and lexA-Srb7 are both cryptic activators that become active in the absence of Srb8, Srb10, Srb11, or Sin4.	lexa	0-4	Srb8p	Saccharomyces cerevisiae S288C	89-93
12468546-5	2003	lexA-Med1 and lexA-Srb7 are both cryptic activators that become active in the absence of Srb8, Srb10, Srb11, or Sin4.	lexa	0-4	cyclin-dependent serine/threonine protein kinase SSN3	Saccharomyces cerevisiae S288C	95-100
12468546-5	2003	lexA-Med1 and lexA-Srb7 are both cryptic activators that become active in the absence of Srb8, Srb10, Srb11, or Sin4.	lexa	0-4	Sin4p	Saccharomyces cerevisiae S288C	112-116
11809791-3	2002	Performing a yeast two-hybrid screen with the c-kit cytoplasmic tail fused to LexA as a bait and a mouse embryo cDNA library as prey, we found that the Grb10 SH2 domain interacted with the c-kit receptor tyrosine kinase.	lexa	78-82	growth factor receptor bound protein 10	Mus musculus	152-157
11809791-3	2002	Performing a yeast two-hybrid screen with the c-kit cytoplasmic tail fused to LexA as a bait and a mouse embryo cDNA library as prey, we found that the Grb10 SH2 domain interacted with the c-kit receptor tyrosine kinase.	lexa	78-82	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	189-194
11106396-6	2000	Aptamers fused to the catalytic domain of a ubiquitin ligase specifically decorated LexA-Cdk2 with ubiquitin moieties in vivo.	lexa	84-88	cyclin dependent kinase 2	Homo sapiens	89-93
9274062-6	1997	Computer analysis of the DNA sequence revealed several possible regulatory motifs 5" to uvr-1+, including a putative LexA-binding site as an inverted SOS box, located within the 3" region of ORF1, (extensive homology to the E. coli CMP-KDO synthetase gene), upstream of uvr-1+.	lexa	117-121	hypothetical protein	Escherichia coli	191-195
10225947-6	1999	Using a transcriptional repression assay, we further showed that most LexA-SR fusion proteins depend on Sky1p to efficiently recognize the LexA binding site in a reporter, suggesting that molecular targeting of RS domain-containing proteins within the nucleus was also affected.	lexa	70-74	serine/threonine protein kinase SKY1	Saccharomyces cerevisiae S288C	104-109
9535852-3	1998	LexA-HSF1 chimeras were previously shown to be regulated identically to HSF1, except that they transactivate promoters with LexA-binding sites instead of hsp promoters.	lexa	0-4	heat shock transcription factor 1	Homo sapiens	5-9
9535852-3	1998	LexA-HSF1 chimeras were previously shown to be regulated identically to HSF1, except that they transactivate promoters with LexA-binding sites instead of hsp promoters.	lexa	0-4	heat shock transcription factor 1	Homo sapiens	72-76
9535852-3	1998	LexA-HSF1 chimeras were previously shown to be regulated identically to HSF1, except that they transactivate promoters with LexA-binding sites instead of hsp promoters.	lexa	0-4	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	154-157
9199298-7	1997	Both LexA-Met31p and LexA-Met32p fusion proteins activate the transcription of a LexAop-containing promoter in a Met4p-dependent manner.	lexa	5-9	Met31p	Saccharomyces cerevisiae S288C	10-16
9199298-7	1997	Both LexA-Met31p and LexA-Met32p fusion proteins activate the transcription of a LexAop-containing promoter in a Met4p-dependent manner.	lexa	5-9	Met4p	Saccharomyces cerevisiae S288C	113-118
8628316-3	1996	To test this, we tethered Sir3p adjacent to the telomere via LexA binding sites in the rap1-17 mutant that truncates the Rap1p C-terminal 165 amino acids thought to contain sites for Sir3p association.	lexa	61-65	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	26-31
8628316-7	1996	In addition, LexA-Sir3p(N2O5) hyperrepresses telomeric silencing when tethered to a subtelomeric site 3.6 kb from the telomeric tract.	lexa	13-17	chromatin-silencing protein SIR3	Saccharomyces cerevisiae S288C	18-23
2152908-5	1990	A similar LexA-binding site can also be found upstream of the nuclease gene.	lexa	10-14	nuclease	Escherichia coli	62-70
7935471-8	1994	This view is supported by observations that several different LexA DNA-binding domain-hHSF1 chimeras bind to a LexA-binding site in a heat-regulated fashion, that single amino acid replacements disrupting the integrity of hydrophobic repeats render these chimeras constitutively trimeric and DNA binding, and that LexA itself binds stably to DNA only as a dimer but not as a monomer in our assays.	lexa	62-66	heat shock transcription factor 1	Homo sapiens	86-91
3547076-7	1987	Second, a lexA-HAP2 fusion gene was capable of activating transcription when bound to a lexA operator site.	lexa	10-14	transcription activator HAP2	Saccharomyces cerevisiae S288C	15-19
35351585-6	2022	Our results hint that our inhibitor"s may function by adopting a beta-hairpin conformation, reminiscent of the native cleavage loop of LexA.	lexa	135-139	amyloid beta precursor protein	Homo sapiens	63-69
6291636-2	1982	Derepressed amounts of recA protein vary over a forty-fold range and correlate well with reduced affinities for lexA repressor of the mutant operators.	lexa	112-116	RAD51 recombinase	Homo sapiens	23-27
32524559-0	2020	Identification of the KRIT1 Protein by LexA-Based Yeast Two-Hybrid System.	lexa	39-43	KRIT1 ankyrin repeat containing	Homo sapiens	22-27