PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1934596-7	1991	Four LL patients with positive T cell response to BCG responded with detectable lymphoproliferative response and IFN-gamma secretion to antigen 85.	bcg	50-53	interferon gamma	Homo sapiens	113-122
9481089-5	1997	Immunofluorescence study showed an increased production of inducible nitric oxide synthase (iNOS) and peroxynitrite in bacille de Calmette-Guerin (BCG)-inoculated human alveolar macrophages (AM).	bcg	147-150	nitric oxide synthase 2	Homo sapiens	59-90
9481089-5	1997	Immunofluorescence study showed an increased production of inducible nitric oxide synthase (iNOS) and peroxynitrite in bacille de Calmette-Guerin (BCG)-inoculated human alveolar macrophages (AM).	bcg	147-150	nitric oxide synthase 2	Homo sapiens	92-96
32167431-4	2021	The aim of this study was to evaluate expression of four genes, namely ASUN, NEMF, PTPRC and DHX29 as candidate biomarkers for the discrimination of Latent tuberculosis infection (LTBI) and active TB among individuals with active TB, LTBI, and healthy Bacilli Calmette-Guerin (BCG) vaccinated cases.	bcg	277-280	integrator complex subunit 13	Homo sapiens	71-75
35074548-6	2022	Patient 2 was a 4-month-old boy whose father was previously diagnosed with autosomal dominant IFN-gammaR1 deficiency owing to Bacille de Calmette et Guerin (BCG) osteomyelitis.	bcg	157-160	interferon gamma receptor 1	Homo sapiens	94-105
33838621-9	2021	The BCG-ACTH interval was shorter in patients with unknown than in those with known etiologies.	bcg	4-7	proopiomelanocortin	Homo sapiens	8-12
33838621-11	2021	The minimum BCG-ACTH interval was 14 days.	bcg	12-15	proopiomelanocortin	Homo sapiens	16-20
33838621-15	2021	The timing of ACTH therapy initiation should be based on the risk of BCG-related adverse events and the adverse effects of any delay.	bcg	69-72	proopiomelanocortin	Homo sapiens	14-18
33384873-2	2021	The adaptive immune response to Bacillus of Calmette and Guerin (BCG) immunization is responded to by B cells, T Follicular B helper, T regulatory, restriction CD1, CD8+, CD4+, Th1, Th2, and Th17.	bcg	65-68	CD1c molecule	Homo sapiens	160-163
33384873-2	2021	The adaptive immune response to Bacillus of Calmette and Guerin (BCG) immunization is responded to by B cells, T Follicular B helper, T regulatory, restriction CD1, CD8+, CD4+, Th1, Th2, and Th17.	bcg	65-68	CD8a molecule	Homo sapiens	165-168
33384873-2	2021	The adaptive immune response to Bacillus of Calmette and Guerin (BCG) immunization is responded to by B cells, T Follicular B helper, T regulatory, restriction CD1, CD8+, CD4+, Th1, Th2, and Th17.	bcg	65-68	CD4 molecule	Homo sapiens	171-174
32655829-6	2020	Plasma IL-1beta, TNF-alpha and IL-4 levels were higher in the ACG than in the BCG (Z = -3.089, -2.458 and -1.987; P = 0.002, 0.014, and 0.047; respectively).	bcg	78-81	interleukin 4	Homo sapiens	31-35
32858539-0	2021	Urothelial Carcinoma In Situ of the Bladder: Correlation of CK20 Expression With Adaptive Immune Resistance, Response to BCG Therapy, and Clinical Outcome.	bcg	121-124	keratin 20	Homo sapiens	60-64
32858539-9	2021	Programmed death ligand-1 and CD8 colocalization seen among patients who failed BCG therapy is an easy assay to perform to identify patients who could potentially benefit from combined BCG therapy and immune checkpoint inhibition.	bcg	80-83	CD8a molecule	Homo sapiens	30-33
32858539-9	2021	Programmed death ligand-1 and CD8 colocalization seen among patients who failed BCG therapy is an easy assay to perform to identify patients who could potentially benefit from combined BCG therapy and immune checkpoint inhibition.	bcg	185-188	CD8a molecule	Homo sapiens	30-33
35430919-8	2022	The highest IFN-gamma concentration was detected in BCG-primed mice that were boosted with HPERC.	bcg	52-55	interferon gamma	Mus musculus	12-21
6394495-1	1984	Lymph node lymphocytes from rabbits sensitized with bacillus Calmet Guerin (BCG) secreted into the culture media both macrophage fusion factor (MFF) and migration inhibition factor (MIF) after 24 h of incubation with heat-killed BCG.	bcg	76-79	mitochondrial fission factor homolog B	Oryctolagus cuniculus	144-147
6394495-1	1984	Lymph node lymphocytes from rabbits sensitized with bacillus Calmet Guerin (BCG) secreted into the culture media both macrophage fusion factor (MFF) and migration inhibition factor (MIF) after 24 h of incubation with heat-killed BCG.	bcg	76-79	macrophage migration inhibitory factor	Oryctolagus cuniculus	182-185
6394495-1	1984	Lymph node lymphocytes from rabbits sensitized with bacillus Calmet Guerin (BCG) secreted into the culture media both macrophage fusion factor (MFF) and migration inhibition factor (MIF) after 24 h of incubation with heat-killed BCG.	bcg	229-232	macrophage migration inhibitory factor	Oryctolagus cuniculus	182-185
33720594-6	2020	Recently, the key role of cytosolic NOD2 receptors in BCG-induced trained immunity has been proven.	bcg	54-57	nucleotide binding oligomerization domain containing 2	Homo sapiens	36-40
30550567-3	2018	We hypothesized that human HSP90B1 regulates monocyte and T-cell responses to Mycobacterium tuberculosis (Mtb) and bacilli Calmette-Guerin (BCG) and that its variants are associated with susceptibility to TB disease.	bcg	140-143	heat shock protein 90 beta family member 1	Homo sapiens	27-34
30372549-8	2019	Accordingly, lung cells from rRv1737c-immunized mice stimulated with killed BCG produced higher levels of multiple cytokines, such as IFN-gamma, IL-10 and IL-6.	bcg	76-79	interferon gamma	Mus musculus	134-143
30372549-8	2019	Accordingly, lung cells from rRv1737c-immunized mice stimulated with killed BCG produced higher levels of multiple cytokines, such as IFN-gamma, IL-10 and IL-6.	bcg	76-79	interleukin 10	Mus musculus	145-150
30372549-8	2019	Accordingly, lung cells from rRv1737c-immunized mice stimulated with killed BCG produced higher levels of multiple cytokines, such as IFN-gamma, IL-10 and IL-6.	bcg	76-79	interleukin 6	Mus musculus	155-159
30550567-4	2018	METHODS: We screened 17 haplotype-tagging SNPs in the HSP90B1 gene region for association with BCG-induced T-cell cytokine responses using both an ex-vivo whole blood assay (N = 295) and an intracellular cytokine staining assay (N = 180) on samples collected 10 weeks after birth.	bcg	95-98	heat shock protein 90 beta family member 1	Homo sapiens	54-61
30550567-9	2018	RESULTS: We identified three SNPs, rs10507172, rs10507173 and rs1920413, that were associated with BCG-induced IL-2 secretion (p = 0.017 for rs10507172 and p = 0.03 for rs10507173 and rs1920413, Mann-Whitney, dominant model).	bcg	99-102	interleukin 2	Homo sapiens	111-115
30550567-12	2018	CONCLUSION: Among infants, an HSP90B1 gene-region variant is associated with BCG-induced IL-2 production and may be associated with protection from TB disease.	bcg	77-80	heat shock protein 90 beta family member 1	Homo sapiens	30-37
30550567-12	2018	CONCLUSION: Among infants, an HSP90B1 gene-region variant is associated with BCG-induced IL-2 production and may be associated with protection from TB disease.	bcg	77-80	interleukin 2	Homo sapiens	89-93
27472280-0	2016	Revisiting the Heterogeneous IFN-gamma Response of Bacille of Calmette-Guerin (BCG)-Revaccinated Healthy Volunteers in a Randomized Controlled Trial: Effect of the Body Mass Index and of the IFNG+874 A/T Polymorphism.	bcg	79-82	interferon gamma	Homo sapiens	29-38
29655632-2	2018	Previous data showed that boosting bacilli Calmette-Guerin (BCG)-vaccinated cattle with a recombinant attenuated human type 5 adenovirally vectored subunit vaccine (Ad5-85A) increased BCG protection and was associated with increased frequency of Ag85A-specific CD4+ T cells post-boosting.	bcg	60-63	Alzheimer disease, familial, type 5	Homo sapiens	165-168
28761743-4	2017	Since the late 70s, the bacillus Calmette-Gurin (BCG) vaccine has been used for intravesical instillation in non-muscle invasive bladder cancer from the mid-90s up until the discovery of tyrosine kinase inhibitors (TKIs) in 2007, interleukin-2 (IL-2) and interferon alpha (IFNalpha), which were the standard of care for metastatic renal-cell cancer.	bcg	49-52	interleukin 2	Homo sapiens	230-243
28761743-4	2017	Since the late 70s, the bacillus Calmette-Gurin (BCG) vaccine has been used for intravesical instillation in non-muscle invasive bladder cancer from the mid-90s up until the discovery of tyrosine kinase inhibitors (TKIs) in 2007, interleukin-2 (IL-2) and interferon alpha (IFNalpha), which were the standard of care for metastatic renal-cell cancer.	bcg	49-52	interleukin 2	Homo sapiens	245-249
28761743-4	2017	Since the late 70s, the bacillus Calmette-Gurin (BCG) vaccine has been used for intravesical instillation in non-muscle invasive bladder cancer from the mid-90s up until the discovery of tyrosine kinase inhibitors (TKIs) in 2007, interleukin-2 (IL-2) and interferon alpha (IFNalpha), which were the standard of care for metastatic renal-cell cancer.	bcg	49-52	interferon alpha 1	Homo sapiens	273-281
28534653-1	2017	BACKGROUND: Oxidative stress produces molecular modifications of serum albumin that disturb its biological functions and interfere with its detection by the bromocresol green assay (BCG).	bcg	182-185	albumin	Homo sapiens	65-78
27208881-2	2016	However, mouse GCPIII was recently shown to cleave beta-citrylglutamate (BCG), suggesting that these two closely related enzymes have distinct functions.	bcg	73-76	N-acetylated alpha-linked acidic dipeptidase 2	Mus musculus	15-21
27458573-5	2016	TLR4 protein expression was up-regulated on macrophages derived from non-bacillus Calmette-Guerin (BCG) vaccinated healthy volunteers after incubation with M. leprae, whereas it was down-regulated in macrophages derived from BCG-vaccinated donors.	bcg	99-102	toll like receptor 4	Homo sapiens	0-4
27458573-6	2016	Finally, pre-treatment of macrophages derived from BCG-naive donors with BCG reversed the effect of M. leprae on TLR4 expression.	bcg	51-54	toll like receptor 4	Homo sapiens	113-117
27458573-6	2016	Finally, pre-treatment of macrophages derived from BCG-naive donors with BCG reversed the effect of M. leprae on TLR4 expression.	bcg	73-76	toll like receptor 4	Homo sapiens	113-117
27208881-6	2016	Additionally, we used X-ray crystallography and computational modelling (quantum and molecular mechanical calculations) to describe the mechanism of BCG binding to the active sites of GCPII and GCPIII, respectively.	bcg	149-152	folate hydrolase 1	Homo sapiens	184-189
27208881-6	2016	Additionally, we used X-ray crystallography and computational modelling (quantum and molecular mechanical calculations) to describe the mechanism of BCG binding to the active sites of GCPII and GCPIII, respectively.	bcg	149-152	folate hydrolase 1B (pseudogene)	Homo sapiens	194-200
27208881-8	2016	Our findings suggest that GCPIII may not act merely as a complementary enzyme to GCPII, and it more likely possesses a specific physiological function related to BCG metabolism in the human body.	bcg	162-165	folate hydrolase 1B (pseudogene)	Homo sapiens	26-32
27208881-8	2016	Our findings suggest that GCPIII may not act merely as a complementary enzyme to GCPII, and it more likely possesses a specific physiological function related to BCG metabolism in the human body.	bcg	162-165	folate hydrolase 1	Homo sapiens	26-31
27208881-9	2016	DATABASE: The X-ray structure of GCPII Glu424Ala in complex with BCG has been deposited in the RCSB Protein Data Bank under accession code 5F09.	bcg	65-68	folate hydrolase 1	Homo sapiens	33-38
25851338-7	2015	The most significant SNP in the TUR group was rs3746162 in GPX4, whose variant genotype conferred a 5.4-fold increased risk of recurrence compared with wild-type (hazard ratio [HR] = 5.43, 95 % confidence interval [CI] = 2.19-13.46), whereas the most significant SNP in the BCG group was rs7265992 in GSS (HR 3.43, 95 % CI 1.56-7.56).	bcg	274-277	glutathione peroxidase 4	Homo sapiens	59-63
27138226-8	2016	Moreover, mice primed with BCG and then supplemented with ESAT-6:CFP-10:Fcgamma2a produced the highest levels of IFN-gamma and IL-12 in immunized groups.	bcg	27-30	interferon gamma	Mus musculus	113-122
25652854-1	2015	OBJECTIVE: To study the effect of Bacilli Calmette-Guerin (BCG) on miRNAs (miR-21, miR-181a, miR-155 and miR-144) in RAW264.7 cells, and with miR-144 as an example, to verify the relationship of miR-144 and Atg4a, an autophagy-related gene, and study the mechanism underlying the regulatory effect of miR-144 on autophagy in the process of Mycobacterium tuberculosis infection.	bcg	59-62	microRNA 21a	Mus musculus	75-81
25652854-1	2015	OBJECTIVE: To study the effect of Bacilli Calmette-Guerin (BCG) on miRNAs (miR-21, miR-181a, miR-155 and miR-144) in RAW264.7 cells, and with miR-144 as an example, to verify the relationship of miR-144 and Atg4a, an autophagy-related gene, and study the mechanism underlying the regulatory effect of miR-144 on autophagy in the process of Mycobacterium tuberculosis infection.	bcg	59-62	microRNA 181a-2	Mus musculus	83-91
25652854-1	2015	OBJECTIVE: To study the effect of Bacilli Calmette-Guerin (BCG) on miRNAs (miR-21, miR-181a, miR-155 and miR-144) in RAW264.7 cells, and with miR-144 as an example, to verify the relationship of miR-144 and Atg4a, an autophagy-related gene, and study the mechanism underlying the regulatory effect of miR-144 on autophagy in the process of Mycobacterium tuberculosis infection.	bcg	59-62	microRNA 155	Mus musculus	93-100
25652854-1	2015	OBJECTIVE: To study the effect of Bacilli Calmette-Guerin (BCG) on miRNAs (miR-21, miR-181a, miR-155 and miR-144) in RAW264.7 cells, and with miR-144 as an example, to verify the relationship of miR-144 and Atg4a, an autophagy-related gene, and study the mechanism underlying the regulatory effect of miR-144 on autophagy in the process of Mycobacterium tuberculosis infection.	bcg	59-62	microRNA 144	Mus musculus	105-112
25652854-1	2015	OBJECTIVE: To study the effect of Bacilli Calmette-Guerin (BCG) on miRNAs (miR-21, miR-181a, miR-155 and miR-144) in RAW264.7 cells, and with miR-144 as an example, to verify the relationship of miR-144 and Atg4a, an autophagy-related gene, and study the mechanism underlying the regulatory effect of miR-144 on autophagy in the process of Mycobacterium tuberculosis infection.	bcg	59-62	microRNA 144	Mus musculus	142-149
25652854-1	2015	OBJECTIVE: To study the effect of Bacilli Calmette-Guerin (BCG) on miRNAs (miR-21, miR-181a, miR-155 and miR-144) in RAW264.7 cells, and with miR-144 as an example, to verify the relationship of miR-144 and Atg4a, an autophagy-related gene, and study the mechanism underlying the regulatory effect of miR-144 on autophagy in the process of Mycobacterium tuberculosis infection.	bcg	59-62	microRNA 144	Mus musculus	142-149
25652854-1	2015	OBJECTIVE: To study the effect of Bacilli Calmette-Guerin (BCG) on miRNAs (miR-21, miR-181a, miR-155 and miR-144) in RAW264.7 cells, and with miR-144 as an example, to verify the relationship of miR-144 and Atg4a, an autophagy-related gene, and study the mechanism underlying the regulatory effect of miR-144 on autophagy in the process of Mycobacterium tuberculosis infection.	bcg	59-62	autophagy related 4A, cysteine peptidase	Mus musculus	207-212
25652854-1	2015	OBJECTIVE: To study the effect of Bacilli Calmette-Guerin (BCG) on miRNAs (miR-21, miR-181a, miR-155 and miR-144) in RAW264.7 cells, and with miR-144 as an example, to verify the relationship of miR-144 and Atg4a, an autophagy-related gene, and study the mechanism underlying the regulatory effect of miR-144 on autophagy in the process of Mycobacterium tuberculosis infection.	bcg	59-62	microRNA 144	Mus musculus	142-149
25652854-7	2015	RESULTS: After BCG stimulated RAW264.7 cells, the expression levels of miR-21, miR-155 and miR-144 were up-regulated, and miR-181a expression was down-regulated.	bcg	15-18	microRNA 21a	Mus musculus	71-77
25652854-7	2015	RESULTS: After BCG stimulated RAW264.7 cells, the expression levels of miR-21, miR-155 and miR-144 were up-regulated, and miR-181a expression was down-regulated.	bcg	15-18	microRNA 155	Mus musculus	79-86
25652854-7	2015	RESULTS: After BCG stimulated RAW264.7 cells, the expression levels of miR-21, miR-155 and miR-144 were up-regulated, and miR-181a expression was down-regulated.	bcg	15-18	microRNA 144	Mus musculus	91-98
25652854-7	2015	RESULTS: After BCG stimulated RAW264.7 cells, the expression levels of miR-21, miR-155 and miR-144 were up-regulated, and miR-181a expression was down-regulated.	bcg	15-18	microRNA 181a-2	Mus musculus	122-130
24636303-3	2014	Vaccination with Bacille Calumette-Guerin (BCG), as well as infection with virulent M. bovis, induces an increase in the frequency and activation of WC1(+) gammadelta T cells circulating in the blood.	bcg	43-46	uncharacterized protein LOC751809	Bos taurus	149-152
24375488-4	2014	The presence of BCG or LPS dynamically reduced the miR-149 expression, along with a substantially striking increase of MyD88 expression in these cells.	bcg	16-19	microRNA 149	Mus musculus	51-58
24375488-4	2014	The presence of BCG or LPS dynamically reduced the miR-149 expression, along with a substantially striking increase of MyD88 expression in these cells.	bcg	16-19	myeloid differentiation primary response gene 88	Mus musculus	119-124
24375488-5	2014	More importantly, overexpression of miR-149 in RAW264.7 cells was associated with a significant decrease of MyD88 protein expression, as well as a reduced production of inflammatory mediator NF-kappaB 1, TNF-alpha and IL-6 in response to BCG infection or LPS stimulation.	bcg	238-241	microRNA 149	Mus musculus	36-43
21908619-1	2011	beta-Citrylglutamate (BCG), a compound present in adult testis and in the CNS during the pre- and perinatal periods is synthesized by an intracellular enzyme encoded by the RIMKLB gene and hydrolyzed by an as yet unidentified ectoenzyme.	bcg	22-25	ribosomal modification protein rimK-like family member B	Mus musculus	173-179
22433404-8	2012	With the effect of BCG, the CD3+CD8+ proportion of the two groups became much higher.	bcg	19-22	CD8a molecule	Homo sapiens	32-35
22092558-4	2011	Knockdown of NaV1.5 reduced high capacity uptake of labeled BCG.	bcg	60-63	sodium voltage-gated channel alpha subunit 5	Homo sapiens	13-19
22092558-5	2011	BCG-containing, NaV1.5-expressing cells demonstrated localization of NaV1.5 and Rab-7 positive endosomes and mitochondria to periphagosome regions that was not observed in NaV1.5-deficient cells.	bcg	0-3	neuron navigator 1	Homo sapiens	16-20
22092558-5	2011	BCG-containing, NaV1.5-expressing cells demonstrated localization of NaV1.5 and Rab-7 positive endosomes and mitochondria to periphagosome regions that was not observed in NaV1.5-deficient cells.	bcg	0-3	sodium voltage-gated channel alpha subunit 5	Homo sapiens	16-22
22092558-5	2011	BCG-containing, NaV1.5-expressing cells demonstrated localization of NaV1.5 and Rab-7 positive endosomes and mitochondria to periphagosome regions that was not observed in NaV1.5-deficient cells.	bcg	0-3	RAB7B, member RAS oncogene family	Homo sapiens	80-85
22092558-5	2011	BCG-containing, NaV1.5-expressing cells demonstrated localization of NaV1.5 and Rab-7 positive endosomes and mitochondria to periphagosome regions that was not observed in NaV1.5-deficient cells.	bcg	0-3	sodium voltage-gated channel alpha subunit 5	Homo sapiens	69-75
24022478-2	2014	Bacillus Calmitte Guerin (BCG) vaccination, known to induce interleukin-1beta in tuberculosis, was originally aimed at tuberculosis control, but it showed efficacy against leprosy.	bcg	26-29	interleukin 1 beta	Homo sapiens	60-77
17919299-1	2007	In this study, the protective efficacy of a novel recombinant bacille Calmette Geurin (BCG) strain (rBCG-AEI) expressing fusion protein the antigen 85B (Ag85B)- the 6-kDa early secreted antigen target (ESAT-6)-IFN-gamma against Mycobacterium tuberculosis H37Rv in mice was evaluated.	bcg	87-90	interferon gamma	Mus musculus	210-219
21314815-5	2011	RESULTS:   Major histocompatibility complex class I-related chain B (MICB) expression was increased  1.5-fold on T24 cells and RT-112 cells with BCG.	bcg	145-148	MHC class I polypeptide-related sequence B	Homo sapiens	69-73
21314815-6	2011	UL-16-binding protein (ULBP) 1 expression was also increased  1.5-fold on T24 cells and RT-112 cells with BCG.	bcg	106-109	UL16 binding protein 1	Homo sapiens	0-30
21891827-11	2011	Furthermore, pretreatment with BCG significantly decreased the mRNA levels of PDE4A, 4C, 5 and 8, which were induced in lungs of allergic rats.	bcg	31-34	phosphodiesterase 4A	Rattus norvegicus	78-83
21234358-0	2011	Induction of granulysin and perforin cytolytic mediator expression in 10-week-old infants vaccinated with BCG at birth.	bcg	106-109	granulysin	Homo sapiens	13-23
17728021-2	2007	The di-GnRH(3)-hinge-MVP miniprotein was conjugated to purified recombinant heat shock protein 65 (Hsp65) of Mycobacterium bovis and used to immunize BALB/c mice primed with subcutaneous injection of Bacillus Calmette-Gurerin (BCG) in the absence of adjuvants.	bcg	227-230	gonadotropin releasing hormone 1	Mus musculus	7-11
17728021-2	2007	The di-GnRH(3)-hinge-MVP miniprotein was conjugated to purified recombinant heat shock protein 65 (Hsp65) of Mycobacterium bovis and used to immunize BALB/c mice primed with subcutaneous injection of Bacillus Calmette-Gurerin (BCG) in the absence of adjuvants.	bcg	227-230	heat shock protein 1 (chaperonin)	Mus musculus	99-104
15850518-1	2005	OBJECTIVE: To investigate the pathophysiological role of CXCL16 in immunological liver injury induced by Bacille de Calmette et Guerin (BCG) and lipopolysaccharides (LPS).	bcg	136-139	chemokine (C-X-C motif) ligand 16	Mus musculus	57-63
15905553-10	2005	These findings infer that the essential minimal requirement for TLR2/4-mediated adjuvancy of BCG lies within a modified MDP.	bcg	93-96	toll like receptor 2	Homo sapiens	64-70
16192577-2	2005	We assessed whether Bec2/bacille Calmette-Guerin (BCG) vaccination prolongs survival in patients with limited-disease small-cell lung cancer (SCLC) after a major response to chemotherapy and chest radiation.	bcg	50-53	potassium voltage-gated channel subfamily H member 4	Homo sapiens	20-48
15178662-10	2004	CD56+ (NK) cells treated with BCG at 0.1 m.o.i.	bcg	30-33	neural cell adhesion molecule 1	Homo sapiens	0-4
12706706-0	2003	BCG (Bacille of Calmette-Guerin) revaccination leads to improved in vitro IFN-gamma response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children.	bcg	0-3	interferon gamma	Homo sapiens	74-83
10222057-5	1999	On the other hand, CD4/CD8 KO mice challenged with live BCG showed initially fewer and smaller granulomas but later more and larger granulomas than control mice.	bcg	56-59	CD4 antigen	Mus musculus	19-22
12043855-2	2002	IL-5 level in response to Der p II was significantly higher in the atopic group than in the nonatopic group both before and after BCG vaccination (p = 0.004, p = 0.009, respectively).	bcg	130-133	interleukin 5	Homo sapiens	0-4
12043855-3	2002	In the atopic group, IgE levels determined in PPD and Der p II stimulated and unstimulated culture supernatants decreased significantly after BCG vaccination (p = 0.028, p = 0.026, p = 0.046, respectively), whereas in the nonatopic group (p = 0.041) BCG vaccination resulted in a significant decrease in IgE level only in response to Der p II stimulation.	bcg	142-145	immunoglobulin heavy constant epsilon	Homo sapiens	21-24
12043855-3	2002	In the atopic group, IgE levels determined in PPD and Der p II stimulated and unstimulated culture supernatants decreased significantly after BCG vaccination (p = 0.028, p = 0.026, p = 0.046, respectively), whereas in the nonatopic group (p = 0.041) BCG vaccination resulted in a significant decrease in IgE level only in response to Der p II stimulation.	bcg	250-253	immunoglobulin heavy constant epsilon	Homo sapiens	21-24
12043855-4	2002	We concluded that in vivo BCG administration can downregulate both spontaneous and stimulated in vitro IgE secretion from PBMC of atopic children.	bcg	26-29	immunoglobulin heavy constant epsilon	Homo sapiens	103-106
11574545-9	2001	In serum-free culture, supplementation of the medium with IGF-1 was required to maintain MAPK phosphorylation and the anti-apoptotic effect of BCG expression.	bcg	143-146	insulin-like growth factor 1	Mus musculus	58-63
11574545-10	2001	BCG-enhanced calcium influx and the presence of insulin-like growth factor-1 may thus activate a cell survival mechanism that selectively protects developing neurons against ceramide-induced apoptosis by up-regulation of MAPK and reduction of PAR-4 expression.	bcg	0-3	PRKC, apoptosis, WT1, regulator	Mus musculus	243-248
11815889-6	2001	In Lewis rats, IL-2 gene expression increased after BCG inoculation, while betamethasone suppressed IL-2 expression.	bcg	52-55	interleukin 2	Rattus norvegicus	15-19
11591115-9	2001	Together, these studies are the first to demonstrate that BCG-induced IL-8 secretion by human monocytes appears to be mediated by intracellular Ca(2+) and is NF-kappaB-dependent and at the same time suggest that production of IL-8 in response to M. bovis BCG can contribute to the initial local and systemic inflammatory response in human tuberculosis.	bcg	255-258	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
10752478-5	2000	Peritumoral injection of various kinds of adjuvant, particularly Freund"s complete adjuvant (FCA) plus bacillus Calmetee-Guerin (BCG), resulted in a marked accumulation of [3H]A-NK cells in mammary tumor tissues 24 h after injection, and simultaneously in the formation of vessels resembling high-endothelium venules (HEV), infiltration of LFA-1+ lymphocytes and expression of the ICAM-1 molecule on the tumor cells in the sites of tumor tissues.	bcg	129-132	integrin subunit alpha L	Rattus norvegicus	340-345
10752478-5	2000	Peritumoral injection of various kinds of adjuvant, particularly Freund"s complete adjuvant (FCA) plus bacillus Calmetee-Guerin (BCG), resulted in a marked accumulation of [3H]A-NK cells in mammary tumor tissues 24 h after injection, and simultaneously in the formation of vessels resembling high-endothelium venules (HEV), infiltration of LFA-1+ lymphocytes and expression of the ICAM-1 molecule on the tumor cells in the sites of tumor tissues.	bcg	129-132	intercellular adhesion molecule 1	Rattus norvegicus	381-387
11591115-2	2001	Because the mechanisms through which Mycobacterium bovis Calmette-Guerin (BCG) induces IL-8 secretion are unknown, the aim of the present study was to characterize the nature of IL-8 production induced by BCG in human monocytes.	bcg	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
11591115-2	2001	Because the mechanisms through which Mycobacterium bovis Calmette-Guerin (BCG) induces IL-8 secretion are unknown, the aim of the present study was to characterize the nature of IL-8 production induced by BCG in human monocytes.	bcg	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
11591115-2	2001	Because the mechanisms through which Mycobacterium bovis Calmette-Guerin (BCG) induces IL-8 secretion are unknown, the aim of the present study was to characterize the nature of IL-8 production induced by BCG in human monocytes.	bcg	205-208	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
11591115-3	2001	In this study, we found that the induction of IL-8 synthesis was dose- and time-dependent after stimulation with BCG.	bcg	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
11591115-5	2001	We also determined that BCG-induced IL-8 secretion occurs through a mechanism that requires intracellular calcium and likely involves a calmodulin-sensitive step.	bcg	24-27	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
11591115-6	2001	Interestingly, BCG-induced secretion of IL-8 from human monocytes resulted from transcriptional up-regulation of the IL-8 gene.	bcg	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
11591115-6	2001	Interestingly, BCG-induced secretion of IL-8 from human monocytes resulted from transcriptional up-regulation of the IL-8 gene.	bcg	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
11591115-9	2001	Together, these studies are the first to demonstrate that BCG-induced IL-8 secretion by human monocytes appears to be mediated by intracellular Ca(2+) and is NF-kappaB-dependent and at the same time suggest that production of IL-8 in response to M. bovis BCG can contribute to the initial local and systemic inflammatory response in human tuberculosis.	bcg	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11591115-9	2001	Together, these studies are the first to demonstrate that BCG-induced IL-8 secretion by human monocytes appears to be mediated by intracellular Ca(2+) and is NF-kappaB-dependent and at the same time suggest that production of IL-8 in response to M. bovis BCG can contribute to the initial local and systemic inflammatory response in human tuberculosis.	bcg	58-61	nuclear factor kappa B subunit 1	Homo sapiens	158-167
11591115-9	2001	Together, these studies are the first to demonstrate that BCG-induced IL-8 secretion by human monocytes appears to be mediated by intracellular Ca(2+) and is NF-kappaB-dependent and at the same time suggest that production of IL-8 in response to M. bovis BCG can contribute to the initial local and systemic inflammatory response in human tuberculosis.	bcg	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
11591115-9	2001	Together, these studies are the first to demonstrate that BCG-induced IL-8 secretion by human monocytes appears to be mediated by intracellular Ca(2+) and is NF-kappaB-dependent and at the same time suggest that production of IL-8 in response to M. bovis BCG can contribute to the initial local and systemic inflammatory response in human tuberculosis.	bcg	255-258	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
10222057-6	1999	CD4/CD8 KO mice had a greater BCG load than control mice.	bcg	30-33	CD4 antigen	Mus musculus	0-3
10194475-3	1999	During pulmonary infection by live Mycobacterium bovis bacilli Calmette-Guerin (BCG) in wild-type mice, lung macrophages released interleukin-12 (IL-12), IFN-gamma, and tumor necrosis factor-alpha (TNF-alpha), and expressed surface activation markers.	bcg	80-83	interferon gamma	Mus musculus	154-163
10194475-3	1999	During pulmonary infection by live Mycobacterium bovis bacilli Calmette-Guerin (BCG) in wild-type mice, lung macrophages released interleukin-12 (IL-12), IFN-gamma, and tumor necrosis factor-alpha (TNF-alpha), and expressed surface activation markers.	bcg	80-83	tumor necrosis factor	Mus musculus	169-196
10194475-3	1999	During pulmonary infection by live Mycobacterium bovis bacilli Calmette-Guerin (BCG) in wild-type mice, lung macrophages released interleukin-12 (IL-12), IFN-gamma, and tumor necrosis factor-alpha (TNF-alpha), and expressed surface activation markers.	bcg	80-83	tumor necrosis factor	Mus musculus	198-207
9463406-6	1998	Furthermore, BCG-induced inhibition of airway eosinophilia was strongly reduced in interferon (IFN)-gamma receptor-deficient mice and could be partially reversed by intranasal IL-5 application.	bcg	13-16	interferon gamma	Mus musculus	83-105
9463406-6	1998	Furthermore, BCG-induced inhibition of airway eosinophilia was strongly reduced in interferon (IFN)-gamma receptor-deficient mice and could be partially reversed by intranasal IL-5 application.	bcg	13-16	interleukin 5	Mus musculus	176-180