PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33731247-10	2021	Furthermore, the ERK inhibitor (PD098059), p38MAPK inhibitor (SB203580), and FAK inhibitor (Y15) reversed these results.	1,2,4,5-benzenetetraamine	92-95	protein tyrosine kinase 2	Homo sapiens	77-80
33748278-3	2021	Here, we investigated the role and mechanism of the FAK inhibitor (1,2,4,5-phenyltetramine tetrahydrochloride (Y15)) in oxidative damage caused by CVC.	1,2,4,5-benzenetetraamine	111-114	protein tyrosine kinase 2	Homo sapiens	52-55
33748278-7	2021	We found that Y15 treatment significantly decreased ROS and MDA levels and increased cell viability, NO, and SOD levels in a time-dependent manner in rabbit serum and cell culture supernatant.	1,2,4,5-benzenetetraamine	14-17	superoxide dismutase 1	Homo sapiens	109-112
33748278-10	2021	These findings suggest that Y15 alleviated CVC-induced oxidative damage to blood vessels by suppressing focal FAK-Akt pathway activation.	1,2,4,5-benzenetetraamine	28-31	protein tyrosine kinase 2	Homo sapiens	110-113
33748278-10	2021	These findings suggest that Y15 alleviated CVC-induced oxidative damage to blood vessels by suppressing focal FAK-Akt pathway activation.	1,2,4,5-benzenetetraamine	28-31	AKT serine/threonine kinase 1	Homo sapiens	114-117
32324278-5	2020	Specific inhibition of FAK signaling with Y15 in subchondral bone resulted in the suppression of subchondral bone deterioration and this effect was mediated by H-type vessel-induced ectopic bone formation.	1,2,4,5-benzenetetraamine	42-45	protein tyrosine kinase 2	Rattus norvegicus	23-26
29484384-4	2018	In the present study, a small-molecule FAK inhibitor, 1,2,4,5-benzenetetramine tetrahydrochloride (Y15), was used to study the effects of FAK inhibition on the adhesion and migration behaviors of vascular endothelial cells (VECs) and human hepatoblastoma cells.	1,2,4,5-benzenetetraamine	54-97	protein tyrosine kinase 2	Homo sapiens	39-42
29484384-4	2018	In the present study, a small-molecule FAK inhibitor, 1,2,4,5-benzenetetramine tetrahydrochloride (Y15), was used to study the effects of FAK inhibition on the adhesion and migration behaviors of vascular endothelial cells (VECs) and human hepatoblastoma cells.	1,2,4,5-benzenetetraamine	54-97	protein tyrosine kinase 2	Homo sapiens	138-141
23792569-2	2013	1,2,4,5-Benzenetetraamine tetrahydrochloride (Y15) is a small molecule FAK inhibitor that blocks the Y397 autophosphorylation site.	1,2,4,5-benzenetetraamine	0-44	protein tyrosine kinase 2	Homo sapiens	71-74
23792569-2	2013	1,2,4,5-Benzenetetraamine tetrahydrochloride (Y15) is a small molecule FAK inhibitor that blocks the Y397 autophosphorylation site.	1,2,4,5-benzenetetraamine	46-49	protein tyrosine kinase 2	Homo sapiens	71-74
12926398-6	2003	The condensation of 2 molar eq. of zinc(II) porphyrin-7,8-dione 8 with 1,2,4,5-benzenetetramine leads to the formation of a 1:1 mixture of syn- and anti-dizinc(II) bis(7,8-capped porphyrins), 11 and 12, respectively, that have almost identical spectroscopic properties.	1,2,4,5-benzenetetraamine	71-95	synemin	Homo sapiens	139-142
21993963-6	2012	The phenomenon was accompanied by thrombin-dependent recovery of depressed autophosphorylation of FAK (pY(397)) under the effect of FAK inhibitor (1,2,4,5-benzenetetramine tetrahydrochloride).	1,2,4,5-benzenetetraamine	147-190	coagulation factor II, thrombin	Homo sapiens	34-42
21993963-6	2012	The phenomenon was accompanied by thrombin-dependent recovery of depressed autophosphorylation of FAK (pY(397)) under the effect of FAK inhibitor (1,2,4,5-benzenetetramine tetrahydrochloride).	1,2,4,5-benzenetetraamine	147-190	protein tyrosine kinase 2	Homo sapiens	98-101
21993963-6	2012	The phenomenon was accompanied by thrombin-dependent recovery of depressed autophosphorylation of FAK (pY(397)) under the effect of FAK inhibitor (1,2,4,5-benzenetetramine tetrahydrochloride).	1,2,4,5-benzenetetraamine	147-190	protein tyrosine kinase 2	Homo sapiens	132-135
22276220-7	2012	Administration of 1,2,4,5-BT and FAK siRNA caused emphysematous lung destruction associated with increased expression of cleaved capase-3, caspase-8 and Bim.	1,2,4,5-benzenetetraamine	18-28	caspase 8	Rattus norvegicus	139-148
21056138-3	2010	Two cell lines were pretreated with the FAK inhibitor 1,2,4,5-benzenetetraamine tetrahydrochloride (Y15) or Akt IV inhibitor, followed by Western analysis for activated FAK and Akt.	1,2,4,5-benzenetetraamine	54-98	protein tyrosine kinase 2	Homo sapiens	40-43
20160475-5	2010	In this study, we have examined the effects of FAK inhibition upon neuroblastoma using a small molecule [1,2,4,5-benzenetetraamine tetrahydrochloride (Y15)] to inhibit FAK expression and the phosphorylation of FAK at the Y397 site.	1,2,4,5-benzenetetraamine	105-149	protein tyrosine kinase 2	Homo sapiens	168-171
20160475-5	2010	In this study, we have examined the effects of FAK inhibition upon neuroblastoma using a small molecule [1,2,4,5-benzenetetraamine tetrahydrochloride (Y15)] to inhibit FAK expression and the phosphorylation of FAK at the Y397 site.	1,2,4,5-benzenetetraamine	105-149	protein tyrosine kinase 2	Homo sapiens	168-171
19571674-4	2009	We identified a novel small molecule inhibitor (1,2,4,5-Benzenetetraamine tetrahydrochloride, that we called Y15) targeting the main autophosphorylation site of FAK and hypothesized that it would be an effective treatment strategy against human pancreatic cancer.	1,2,4,5-benzenetetraamine	48-92	protein tyrosine kinase 2	Homo sapiens	161-164
19571674-10	2009	Thus, targeting the Y397 site of FAK in pancreatic cancer with the small molecule inhibitor, 1,2,4,5-Benzenetetraamine tetrahydrochloride, is a potentially effective treatment strategy in this deadly disease.	1,2,4,5-benzenetetraamine	93-137	protein tyrosine kinase 2	Homo sapiens	33-36
18989950-0	2008	A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.	1,2,4,5-benzenetetraamine	28-72	protein tyrosine kinase 2	Homo sapiens	101-122
35220396-6	2022	Treatment with DDK inhibitors dramatically reduced the rate of replication, prolonged S-phase, and led to a pronounced increase in phospho-CDC2 (Y15), indicating delay of mitotic entry.	1,2,4,5-benzenetetraamine	145-148	cyclin dependent kinase 1	Homo sapiens	139-143